Akiko Hata, PhD

Title(s)Professor, Cardiovascular Research Inst
SchoolSchool of Medicine
Address555 Mission Bay Blvd South, #212
San Francisco CA 94158
Phone--
ORCID ORCID Icon0000-0003-3784-1738 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of Tokyo, Tokyo, JapanMS04/1990Molecular Biology
    The Rockefeller University, New York, NYPhD04/1995Signaling, Virology
    Memorial Sloan-Kettering Cancer Institute, New York, NYPost-doc05/2000Signaling, Cell Biology
    University of California, San Francisco, San Francisco, CA09/2020Diversity, Equity and Inclusion Training

    Collapse Overview 
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    Collapse Research 
    Collapse Research Activities and Funding
    Elucidating the structural insights into the BMP receptor
    NIH/NHLBI R01HL164581Jun 1, 2023 - Mar 31, 2027
    Role: Principle Investigator
    Molecular pathogenesis of pulmonary arterial hypertension
    NIH R01HL153915May 1, 2021 - Jan 31, 2025
    Role: Principal Investigator
    Role of DNA damage in Pulmonary Artery Hypertension
    TRDRP 587294Jul 1, 2018 - Dec 31, 2023
    Role: Principle Investigator
    Description: The goal of this study is to elucidate the role of genomic insult as a result of BMPR2 mutations in the pathogenesis of pulmonary artery hypertension.
    FASEB SRC on TGF-beta Superfamily: Signaling in Development and Disease
    NIH R13CA217045Jul 1, 2017 - Jun 30, 2018
    Role: Principal Investigator
    Identification of a novel modulator of Pulmonary Artery Hypertension
    NIH R01HL132058Jun 1, 2016 - Mar 31, 2021
    Role: Principal Investigator
    FASEB SRC on TGF-beta Superfamily: Signaling in Development and Disease
    NIH R13CA196044May 20, 2015 - Apr 30, 2016
    Role: Principal Investigator
    Role of the PDGF signaling pathway in pulmonary artery hypertension
    NIH R01HL116191Aug 15, 2013 - May 31, 2018
    Role: Principal Investigator
    Role of miRNAs in Vascular Physiology
    NIH R01HL093154Jun 1, 2009 - Apr 30, 2014
    Role: Principal Investigator
    Role of BMPRII Mutants in the Pathogenesis of Pulmonary Hypertension
    NIH R01HL082854Jul 1, 2006 - Jun 30, 2011
    Role: Principal Investigator
    Mechanisms of TGFB Signal Transduction
    NIH R01HD042149Jul 7, 2003 - May 31, 2010
    Role: Principal Investigator
    Mechanisms of TGFB Signal Transduction
    NIH R01HL108317Apr 1, 2002 - Mar 31, 2016
    Role: Principal Investigator
    Elucidating the structural insights into the BMP receptor
    NHLBI R01HL164581
    Role: PI

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Reversal of pulmonary veno-occlusive disease phenotypes by inhibition of the integrated stress response. bioRxiv. 2023 Nov 28. Prabhakar A, Kumar R, Wadhwa M, Ghatpande P, Zhang J, Zhao Z, Lizama CO, Kharbikar BN, Gräf S, Treacy CM, Morrell NW, Graham BB, Lagna G, Hata A. PMID: 38076809; PMCID: PMC10705277.
      View in: PubMed   Mentions:
    2. Essential role of the amino-terminal region of Drosha for the Microprocessor function. iScience. 2023 Oct 20; 26(10):107971. Prabhakar A, Hu S, Tang J, Ghatpande P, Lagna G, Jiang X, Hata A. PMID: 37810246; PMCID: PMC10558778.
      View in: PubMed   Mentions:
    3. Development and Characterization of Type I, Type II, and Type III LIM-Kinase Chemical Probes. J Med Chem. 2022 10 13; 65(19):13264-13287. Hanke T, Mathea S, Woortman J, Salah E, Berger BT, Tumber A, Kashima R, Hata A, Kuster B, Müller S, Knapp S. PMID: 36136092; PMCID: PMC9675044.
      View in: PubMed   Mentions: 2     Fields:    
    4. Combination Therapy with STAT3 Inhibitor Enhances SERCA2a-Induced BMPR2 Expression and Inhibits Pulmonary Arterial Hypertension. Int J Mol Sci. 2021 Aug 24; 22(17). Bisserier M, Katz MG, Bueno-Beti C, Brojakowska A, Zhang S, Gubara S, Kohlbrenner E, Fazal S, Fargnoli A, Dorfmuller P, Humbert M, Hata A, Goukassian DA, Sassi Y, Hadri L. PMID: 34502015; PMCID: PMC8431626.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    5. Structural basis for ALK2/BMPR2 receptor complex signaling through kinase domain oligomerization. Nat Commun. 2021 08 16; 12(1):4950. Agnew C, Ayaz P, Kashima R, Loving HS, Ghatpande P, Kung JE, Underbakke ES, Shan Y, Shaw DE, Hata A, Jura N. PMID: 34400635; PMCID: PMC8368100.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    6. How do you mend inactive tumor suppressor mutants? You glue them! Cell Chem Biol. 2021 05 20; 28(5):585-587. Hata A, Lagna G. PMID: 34019843.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    7. Control of ribosomal protein synthesis by the Microprocessor complex. Sci Signal. 2021 02 23; 14(671). Jiang X, Prabhakar A, Van der Voorn SM, Ghatpande P, Celona B, Venkataramanan S, Calviello L, Lin C, Wang W, Black BL, Floor SN, Lagna G, Hata A. PMID: 33622983; PMCID: PMC8012103.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    8. Deletion of Mediator 1 suppresses TGFβ signaling leading to changes in epidermal lineages and regeneration. PLoS One. 2020; 15(8):e0238076. Oda Y, Nguyen T, Hata A, Meyer MB, Pike JW, Bikle DD. PMID: 32857768; PMCID: PMC7455038.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    9. Deregulation of Drosha in the pathogenesis of hereditary hemorrhagic telangiectasia. Curr Opin Hematol. 2019 05; 26(3):161-169. Hata A, Lagna G. PMID: 30855334; PMCID: PMC6476316.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    10. Bone morphogenetic protein signaling is required for RAD51-mediated maintenance of genome integrity in vascular endothelial cells. Commun Biol. 2018; 1:149. Vattulainen-Collanus S, Southwood M, Yang XD, Moore S, Ghatpande P, Morrell NW, Lagna G, Hata A. PMID: 30272025; PMCID: PMC6155317.
      View in: PubMed   Mentions: 8  
    11. Analysis of the microRNA signature driving adaptive right ventricular hypertrophy in an ovine model of congenital heart disease. Am J Physiol Heart Circ Physiol. 2018 10 01; 315(4):H847-H854. Kameny RJ, He Y, Zhu T, Gong W, Raff GW, Chapin CJ, Datar SA, Boehme JT, Hata A, Fineman JR. PMID: 29906222; PMCID: PMC6230913.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    12. Inactivating mutations in Drosha mediate vascular abnormalities similar to hereditary hemorrhagic telangiectasia. Sci Signal. 2018 01 16; 11(513). Jiang X, Wooderchak-Donahue WL, McDonald J, Ghatpande P, Baalbaki M, Sandoval M, Hart D, Clay H, Coughlin S, Lagna G, Bayrak-Toydemir P, Hata A. PMID: 29339534; PMCID: PMC5811261.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    13. The role of TGF-β superfamily signaling in neurological disorders. Acta Biochim Biophys Sin (Shanghai). 2018 Jan 01; 50(1):106-120. Kashima R, Hata A. PMID: 29190314; PMCID: PMC5846707.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    14. Identification of MicroRNA-124 as a Major Regulator of Enhanced Endothelial Cell Glycolysis in Pulmonary Arterial Hypertension via PTBP1 (Polypyrimidine Tract Binding Protein) and Pyruvate Kinase M2. Circulation. 2017 Dec 19; 136(25):2451-2467. Caruso P, Dunmore BJ, Schlosser K, Schoors S, Dos Santos C, Perez-Iratxeta C, Lavoie JR, Zhang H, Long L, Flockton AR, Frid MG, Upton PD, D'Alessandro A, Hadinnapola C, Kiskin FN, Taha M, Hurst LA, Ormiston ML, Hata A, Stenmark KR, Carmeliet P, Stewart DJ, Morrell NW. PMID: 28971999; PMCID: PMC5736425.
      View in: PubMed   Mentions: 119     Fields:    Translation:HumansAnimalsCells
    15. Let-7 microRNA-dependent control of leukotriene signaling regulates the transition of hematopoietic niche in mice. Nat Commun. 2017 07 25; 8(1):128. Jiang X, Hawkins JS, Lee J, Lizama CO, Bos FL, Zape JP, Ghatpande P, Peng Y, Louie J, Lagna G, Zovein AC, Hata A. PMID: 28743859; PMCID: PMC5527007.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    16. Hyperactive locomotion in a Drosophila model is a functional readout for the synaptic abnormalities underlying fragile X syndrome. Sci Signal. 2017 May 02; 10(477). Kashima R, Redmond PL, Ghatpande P, Roy S, Kornberg TB, Hanke T, Knapp S, Lagna G, Hata A. PMID: 28465421; PMCID: PMC5557344.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    17. Suppression of C9orf72 RNA repeat-induced neurotoxicity by the ALS-associated RNA-binding protein Zfp106. Elife. 2017 01 10; 6. Celona B, Dollen JV, Vatsavayai SC, Kashima R, Johnson JR, Tang AA, Hata A, Miller BL, Huang EJ, Krogan NJ, Seeley WW, Black BL. PMID: 28072389; PMCID: PMC5283830.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    18. TGF-β Signaling from Receptors to Smads. Cold Spring Harb Perspect Biol. 2016 Sep 01; 8(9). Hata A, Chen YG. PMID: 27449815; PMCID: PMC5008074.
      View in: PubMed   Mentions: 336     Fields:    Translation:HumansAnimalsCells
    19. Augmented noncanonical BMP type II receptor signaling mediates the synaptic abnormality of fragile X syndrome. Sci Signal. 2016 06 07; 9(431):ra58. Kashima R, Roy S, Ascano M, Martinez-Cerdeno V, Ariza-Torres J, Kim S, Louie J, Lu Y, Leyton P, Bloch KD, Kornberg TB, Hagerman PJ, Hagerman R, Lagna G, Hata A. PMID: 27273096; PMCID: PMC5274719.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    20. Quantitative Real-Time PCR Analysis of MicroRNAs and Their Precursors Regulated by TGF-β Signaling. Methods Mol Biol. 2016; 1344:313-23. Kang H, Hata A. PMID: 26520134.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    21. Dysregulation of microRNA biogenesis machinery in cancer. Crit Rev Biochem Mol Biol. 2016 May-Jun; 51(3):121-34. Hata A, Kashima R. PMID: 26628006; PMCID: PMC5226641.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimalsCells
    22. Targeting BMP signalling in cardiovascular disease and anaemia. Nat Rev Cardiol. 2016 Feb; 13(2):106-20. Morrell NW, Bloch DB, ten Dijke P, Goumans MJ, Hata A, Smith J, Yu PB, Bloch KD. PMID: 26461965; PMCID: PMC4886232.
      View in: PubMed   Mentions: 111     Fields:    Translation:HumansCells
    23. Therapeutic Ultrasound Promotes Reperfusion and Angiogenesis in a Rat Model of Peripheral Arterial Disease. Circ J. 2015; 79(9):2043-9. Nazer B, Ghahghaie F, Kashima R, Khokhlova T, Perez C, Crum L, Matula T, Hata A. PMID: 26062950.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    24. The role of microRNAs in cell fate determination of mesenchymal stem cells: balancing adipogenesis and osteogenesis. BMB Rep. 2015 Jun; 48(6):319-23. Kang H, Hata A. PMID: 25341923; PMCID: PMC4578617.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    25. Disruption of miR-29 Leads to Aberrant Differentiation of Smooth Muscle Cells Selectively Associated with Distal Lung Vasculature. PLoS Genet. 2015 May; 11(5):e1005238. Cushing L, Costinean S, Xu W, Jiang Z, Madden L, Kuang P, Huang J, Weisman A, Hata A, Croce CM, Lü J. PMID: 26020233; PMCID: PMC4447351.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimals
    26. Dysregulation of microRNA biogenesis and gene silencing in cancer. Sci Signal. 2015 Mar 17; 8(368):re3. Hata A, Lieberman J. PMID: 25783160.
      View in: PubMed   Mentions: 108     Fields:    Translation:HumansAnimalsCells
    27. Functions of the bone morphogenetic protein signaling pathway through microRNAs (review). Int J Mol Med. 2015 Mar; 35(3):563-8. Hata A, Kang H. PMID: 25571950; PMCID: PMC6904101.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    28. Down-regulation of miR-96 by bone morphogenetic protein signaling is critical for vascular smooth muscle cell phenotype modulation. J Cell Biochem. 2014 May; 115(5):889-95. Kim S, Hata A, Kang H. PMID: 24375867; PMCID: PMC5215840.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    29. Cardiovascular applications of therapeutic ultrasound. J Interv Card Electrophysiol. 2014 Apr; 39(3):287-94. Nazer B, Gerstenfeld EP, Hata A, Crum LA, Matula TJ. PMID: 24297498; PMCID: PMC5215834.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    30. Acetylation of p53 stimulates miRNA processing and determines cell survival following genotoxic stress. EMBO J. 2013 Dec 11; 32(24):3192-205. Chang J, Davis-Dusenbery BN, Kashima R, Jiang X, Marathe N, Sessa R, Louie J, Gu W, Lagna G, Hata A. PMID: 24219989; PMCID: PMC3981142.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    31. Atrial natriuretic peptide is negatively regulated by microRNA-425. J Clin Invest. 2013 Aug; 123(8):3378-82. Arora P, Wu C, Khan AM, Bloch DB, Davis-Dusenbery BN, Ghorbani A, Spagnolli E, Martinez A, Ryan A, Tainsh LT, Kim S, Rong J, Huan T, Freedman JE, Levy D, Miller KK, Hata A, Del Monte F, Vandenwijngaert S, Swinnen M, Janssens S, Holmes TM, Buys ES, Bloch KD, Newton-Cheh C, Wang TJ. PMID: 23867623; PMCID: PMC3726159.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    32. Role of microRNAs in lung development and pulmonary diseases. Pulm Circ. 2013 Apr; 3(2):315-28. Sessa R, Hata A. PMID: 24015331; PMCID: PMC3757825.
      View in: PubMed   Mentions: 82  
    33. Regulation of miRNA biogenesis as an integrated component of growth factor signaling. Curr Opin Cell Biol. 2013 Apr; 25(2):233-40. Blahna MT, Hata A. PMID: 23312066; PMCID: PMC4429755.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    34. Functions of microRNAs in cardiovascular biology and disease. Annu Rev Physiol. 2013; 75:69-93. Hata A. PMID: 23157557; PMCID: PMC5215839.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimals
    35. Targeting the TGFβ signalling pathway in disease. Nat Rev Drug Discov. 2012 Oct; 11(10):790-811. Akhurst RJ, Hata A. PMID: 23000686; PMCID: PMC3520610.
      View in: PubMed   Mentions: 727     Fields:    Translation:HumansAnimalsCells
    36. Inhibition of microRNA-302 (miR-302) by bone morphogenetic protein 4 (BMP4) facilitates the BMP signaling pathway. J Biol Chem. 2012 Nov 09; 287(46):38656-64. Kang H, Louie J, Weisman A, Sheu-Gruttadauria J, Davis-Dusenbery BN, Lagna G, Hata A. PMID: 22988237; PMCID: PMC3493910.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    37. Bone morphogenetic protein signaling in vascular disease: anti-inflammatory action through myocardin-related transcription factor A. J Biol Chem. 2012 Aug 10; 287(33):28067-77. Wang D, Prakash J, Nguyen P, Davis-Dusenbery BN, Hill NS, Layne MD, Hata A, Lagna G. PMID: 22718766; PMCID: PMC3431673.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    38. MicroRNA regulation of smooth muscle gene expression and phenotype. Curr Opin Hematol. 2012 May; 19(3):224-31. Kang H, Hata A. PMID: 22406821; PMCID: PMC5226630.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    39. A taste of TGFβ in Tuscany. Development. 2012 Feb; 139(3):449-53. Hata A, Brivanlou AH. PMID: 22223676.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    40. Smad-mediated regulation of microRNA biosynthesis. FEBS Lett. 2012 Jul 04; 586(14):1906-12. Blahna MT, Hata A. PMID: 22306316; PMCID: PMC4429768.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    41. Bone morphogenetic protein 4 promotes vascular smooth muscle contractility by activating microRNA-21 (miR-21), which down-regulates expression of family of dedicator of cytokinesis (DOCK) proteins. J Biol Chem. 2012 Feb 03; 287(6):3976-86. Kang H, Davis-Dusenbery BN, Nguyen PH, Lal A, Lieberman J, Van Aelst L, Lagna G, Hata A. PMID: 22158624; PMCID: PMC3281737.
      View in: PubMed   Mentions: 53     Fields:    Translation:Humans
    42. MicroRNA and vascular remodelling in acute vascular injury and pulmonary vascular remodelling. Cardiovasc Res. 2012 Mar 15; 93(4):594-604. McDonald RA, Hata A, MacLean MR, Morrell NW, Baker AH. PMID: 22065733; PMCID: PMC3410429.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    43. Micromanaging vascular smooth muscle cell differentiation and phenotypic modulation. Arterioscler Thromb Vasc Biol. 2011 Nov; 31(11):2370-7. Davis-Dusenbery BN, Wu C, Hata A. PMID: 22011749; PMCID: PMC4429757.
      View in: PubMed   Mentions: 115     Fields:    Translation:HumansAnimalsCells
    44. Hypoxia potentiates microRNA-mediated gene silencing through posttranslational modification of Argonaute2. Mol Cell Biol. 2011 Dec; 31(23):4760-74. Wu C, So J, Davis-Dusenbery BN, Qi HH, Bloch DB, Shi Y, Lagna G, Hata A. PMID: 21969601; PMCID: PMC3232924.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    45. down-regulation of Kruppel-like factor-4 (KLF4) by microRNA-143/145 is critical for modulation of vascular smooth muscle cell phenotype by transforming growth factor-beta and bone morphogenetic protein 4. J Biol Chem. 2011 Aug 12; 286(32):28097-110. Davis-Dusenbery BN, Chan MC, Reno KE, Weisman AS, Layne MD, Lagna G, Hata A. PMID: 21673106; PMCID: PMC3151055.
      View in: PubMed   Mentions: 131     Fields:    Translation:HumansAnimalsCells
    46. Regulation of pri-miRNA Processing Through Smads. Adv Exp Med Biol. 2011; 700:15-27. Hata A, Davis BN. PMID: 21755469.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    47. Smad-mediated miRNA processing: a critical role for a conserved RNA sequence. RNA Biol. 2011 Jan-Feb; 8(1):71-6. Davis-Dusenbery BN, Hata A. PMID: 21289485; PMCID: PMC3230544.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    48. The amiloride derivative phenamil attenuates pulmonary vascular remodeling by activating NFAT and the bone morphogenetic protein signaling pathway. Mol Cell Biol. 2011 Feb; 31(3):517-30. Chan MC, Weisman AS, Kang H, Nguyen PH, Hickman T, Mecker SV, Hill NS, Lagna G, Hata A. PMID: 21135135; PMCID: PMC3028626.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    49. MicroRNA in Cancer: The Involvement of Aberrant MicroRNA Biogenesis Regulatory Pathways. Genes Cancer. 2010 Nov; 1(11):1100-14. Davis-Dusenbery BN, Hata A. PMID: 21533017; PMCID: PMC3083114.
      View in: PubMed   Mentions: 87  
    50. Mechanisms of control of microRNA biogenesis. J Biochem. 2010 Oct; 148(4):381-92. Davis-Dusenbery BN, Hata A. PMID: 20833630; PMCID: PMC2981492.
      View in: PubMed   Mentions: 121     Fields:    Translation:HumansCells
    51. Smad proteins bind a conserved RNA sequence to promote microRNA maturation by Drosha. Mol Cell. 2010 Aug 13; 39(3):373-84. Davis BN, Hilyard AC, Nguyen PH, Lagna G, Hata A. PMID: 20705240; PMCID: PMC2921543.
      View in: PubMed   Mentions: 214     Fields:    Translation:HumansCells
    52. Regulation of pri-miRNA processing through Smads. Adv Exp Med Biol. 2010; 700:15-27. Hata A, Davis BN. PMID: 21627026.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    53. Molecular basis for antagonism between PDGF and the TGFbeta family of signalling pathways by control of miR-24 expression. EMBO J. 2010 Feb 03; 29(3):559-73. Chan MC, Hilyard AC, Wu C, Davis BN, Hill NS, Lal A, Lieberman J, Lagna G, Hata A. PMID: 20019669; PMCID: PMC2830697.
      View in: PubMed   Mentions: 112     Fields:    Translation:HumansAnimalsCells
    54. Control of microRNA biogenesis by TGFbeta signaling pathway-A novel role of Smads in the nucleus. Cytokine Growth Factor Rev. 2009 Oct-Dec; 20(5-6):517-21. Hata A, Davis BN. PMID: 19892582; PMCID: PMC2787811.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    55. Regulation of MicroRNA Biogenesis: A miRiad of mechanisms. Cell Commun Signal. 2009 Aug 10; 7:18. Davis BN, Hata A. PMID: 19664273; PMCID: PMC3224893.
      View in: PubMed   Mentions: 157     Fields:    
    56. ZNF423 is critically required for retinoic acid-induced differentiation and is a marker of neuroblastoma outcome. Cancer Cell. 2009 Apr 07; 15(4):328-40. Huang S, Laoukili J, Epping MT, Koster J, Hölzel M, Westerman BA, Nijkamp W, Hata A, Asgharzadeh S, Seeger RC, Versteeg R, Beijersbergen RL, Bernards R. PMID: 19345331; PMCID: PMC2693316.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansCells
    57. The four-and-a-half LIM domain protein 2 regulates vascular smooth muscle phenotype and vascular tone. J Biol Chem. 2009 May 08; 284(19):13202-12. Neuman NA, Ma S, Schnitzler GR, Zhu Y, Lagna G, Hata A. PMID: 19265191; PMCID: PMC2676052.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    58. Induction of microRNA-221 by platelet-derived growth factor signaling is critical for modulation of vascular smooth muscle phenotype. J Biol Chem. 2009 Feb 06; 284(6):3728-38. Davis BN, Hilyard AC, Nguyen PH, Lagna G, Hata A. PMID: 19088079; PMCID: PMC2635044.
      View in: PubMed   Mentions: 158     Fields:    Translation:HumansCells
    59. SMAD proteins control DROSHA-mediated microRNA maturation. Nature. 2008 Jul 03; 454(7200):56-61. Davis BN, Hilyard AC, Lagna G, Hata A. PMID: 18548003; PMCID: PMC2653422.
      View in: PubMed   Mentions: 710     Fields:    Translation:HumansAnimalsCells
    60. Control of phenotypic plasticity of smooth muscle cells by bone morphogenetic protein signaling through the myocardin-related transcription factors. J Biol Chem. 2007 Dec 21; 282(51):37244-55. Lagna G, Ku MM, Nguyen PH, Neuman NA, Davis BN, Hata A. PMID: 17947237; PMCID: PMC3405982.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansCells
    61. A novel regulatory mechanism of the bone morphogenetic protein (BMP) signaling pathway involving the carboxyl-terminal tail domain of BMP type II receptor. Mol Cell Biol. 2007 Aug; 27(16):5776-89. Chan MC, Nguyen PH, Davis BN, Ohoka N, Hayashi H, Du K, Lagna G, Hata A. PMID: 17576816; PMCID: PMC1952124.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    62. BMP-dependent activation of caspase-9 and caspase-8 mediates apoptosis in pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2006 Nov; 291(5):L1059-67. Lagna G, Nguyen PH, Ni W, Hata A. PMID: 17030903.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    63. OAZ regulates bone morphogenetic protein signaling through Smad6 activation. J Biol Chem. 2006 Feb 24; 281(8):5277-87. Ku M, Howard S, Ni W, Lagna G, Hata A. PMID: 16373339.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    64. Positive and negative regulation of the transforming growth factor beta/activin target gene goosecoid by the TFII-I family of transcription factors. Mol Cell Biol. 2005 Aug; 25(16):7144-57. Ku M, Sokol SY, Wu J, Tussie-Luna MI, Roy AL, Hata A. PMID: 16055724; PMCID: PMC1190264.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    65. Indian hedgehog gene is a target of the bone morphogenetic protein signaling pathway. J Biol Chem. 2004 Apr 30; 279(18):18544-9. Seki K, Hata A. PMID: 14981086.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    66. Poly(ADP-ribose) polymerase 1 interacts with OAZ and regulates BMP-target genes. Biochem Biophys Res Commun. 2003 Nov 21; 311(3):702-7. Ku MC, Stewart S, Hata A. PMID: 14623329.
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    67. Early hematopoietic zinc finger protein (EHZF), the human homolog to mouse Evi3, is highly expressed in primitive human hematopoietic cells. Blood. 2004 Mar 15; 103(6):2062-70. Bond HM, Mesuraca M, Carbone E, Bonelli P, Agosti V, Amodio N, De Rosa G, Di Nicola M, Gianni AM, Moore MA, Hata A, Grieco M, Morrone G, Venuta S. PMID: 14630787.
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    68. Mouse Snail family transcription repressors regulate chondrocyte, extracellular matrix, type II collagen, and aggrecan. J Biol Chem. 2003 Oct 24; 278(43):41862-70. Seki K, Fujimori T, Savagner P, Hata A, Aikawa T, Ogata N, Nabeshima Y, Kaechoong L. PMID: 12917416; PMCID: PMC2253659.
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