Aras Mattis, MD, PhD

Title(s)Associate Professor, Pathology
SchoolSchool of Medicine
Address513 Parnassus Ave, HSW, #516
San Francisco CA 94143
Phone415-514-3062
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    Collapse Research 
    Collapse Research Activities and Funding
    Establishing patient-derived iPSCs as a platform for discovery research in NAFLD
    NIDDK RC2DK136052Jun 1, 2023 - May 30, 2028
    Role: MPI
    Genetic Regulation of Nonalcoholic Fatty Liver Disease
    NIH R01DK130391Jun 8, 2021 - Mar 31, 2025
    Role: MPI
    Regulation of Lipid Metabolism by miR-29a within Hepatocytes
    NIH K08DK098270Sep 1, 2013 - Jul 31, 2019
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. AMPK stimulation inhibits YAP/TAZ signaling to ameliorate hepatic fibrosis. Sci Rep. 2024 03 03; 14(1):5205. Shihan MH, Sharma S, Cable C, Prathigudupu V, Chen A, Mattis AN, Chen JY. PMID: 38433278; PMCID: PMC10909858.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    2. Fluoride-related changes in the fetal cord blood proteome; a pilot study. Res Sq. 2024 Mar 01. Tuomivaara ST, Goin DE, Fisher SJ, Hall SC, Mattis AN, Den Besten PK. PMID: 38464284; PMCID: PMC10925477.
      View in: PubMed   Mentions:
    3. MicroRNAs Associated with Metformin Treatment in the Diabetes Prevention Program. Res Sq. 2024 Jan 16. Lewis KA, Stroebel B, Zhang L, Aouizerat B, Mattis A, Flowers E. PMID: 38313262; PMCID: PMC10836103.
      View in: PubMed   Mentions:
    4. Hyperpolarized [1-13 C] pyruvate MRSI to detect metabolic changes in liver in a methionine and choline-deficient diet rat model of fatty liver disease. Magn Reson Med. 2024 Apr; 91(4):1625-1636. Piraquive Agudelo J, Kim Y, Agarwal S, Sriram R, Bok R, Kurhanewicz J, Mattis AN, Maher JJ, von Morze C, Ohliger MA. PMID: 38115605.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    5. Group 2 innate lymphoid cells constrain type 3/17 lymphocytes in shared stromal niches to restrict liver fibrosis. bioRxiv. 2023 Apr 28. Sbierski-Kind J, Cautivo KM, Wagner JC, Dahlgren MW, Nilsson J, Krasilnikov M, Mroz NM, Lizama CO, Gan AL, Matatia PR, Taruselli MT, Chang AA, Caryotakis S, O'Leary CE, Kotas M, Mattis AN, Peng T, Locksley RM, Molofsky AB. PMID: 37163060; PMCID: PMC10168323.
      View in: PubMed   Mentions:
    6. Metastatic colorectal adenocarcinoma tumor purity assessment from whole exome sequencing data. PLoS One. 2023; 18(4):e0271354. Tbeileh N, Timmerman L, Mattis AN, Toriguchi K, Kasai Y, Corvera C, Nakakura E, Hirose K, Donner DB, Warren RS, Karelehto E. PMID: 37022995; PMCID: PMC10079084.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. DNA content abnormality frequently develops in the right/proximal colon in patients with primary sclerosing cholangitis and inflammatory bowel disease and is highly predictive of subsequent detection of dysplasia. Histopathology. 2023 Jul; 83(1):116-125. Zhang R, Rabinovitch PS, Mattis AN, Lauwers GY, Choi WT. PMID: 37012656.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Self-Assembled Matrigel-Free iPSC-Derived Liver Organoids Demonstrate Wide-Ranging Highly Differentiated Liver Functions. Stem Cells. 2023 03 02; 41(2):126-139. Weng Y, Han S, Sekyi MT, Su T, Mattis AN, Chang TT. PMID: 36573434; PMCID: PMC9982071.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    9. Fundic Gland Polyps Lack DNA Content Abnormality Characteristic of Other Adenomatous Precursor Lesions in the Gastrointestinal Tract. Mod Pathol. 2023 05; 36(5):100117. Akanuma N, Rabinovitch PS, Mattis AN, Lauwers GY, Choi WT. PMID: 36805791.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Transient expression of factor VIII and a chronic high-fat diet induces ER stress and late hepatocyte oncogenesis. Mol Ther. 2022 12 07; 30(12):3510-3512. Pierce GF, Mattis AN. PMID: 36423626; PMCID: PMC9734076.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    11. Targeting acid ceramidase ameliorates fibrosis in mouse models of non-alcoholic steatohepatitis. Front Med (Lausanne). 2022; 9:881848. Yu A, Cable C, Sharma S, Shihan MH, Mattis AN, Mileva I, Hannun YA, Duwaerts CC, Chen JY. PMID: 36275798; PMCID: PMC9582277.
      View in: PubMed   Mentions: 1  
    12. Undifferentiated Induced Pluripotent Stem Cells as a Genetic Model for Nonalcoholic Fatty Liver Disease. Cell Mol Gastroenterol Hepatol. 2022; 14(5):1174-1176.e6. Muñoz A, Theusch E, Kuang YL, Nalula G, Peaslee C, Dorlhiac G, Landry MP, Streets A, Krauss RM, Iribarren C, Mattis AN, Medina MW. PMID: 35863744; PMCID: PMC9608362.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    13. Clinical Application of Induced Hepatocyte-like Cells Produced from Mesenchymal Stromal Cells: A Literature Review. Cells. 2022 06 22; 11(13). Bogliotti Y, Vander Roest M, Mattis AN, Gish RG, Peltz G, Anwyl R, Kivlighn S, Schuur ER. PMID: 35805080; PMCID: PMC9265349.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    14. Interindividual variability in transgene mRNA and protein production following adeno-associated virus gene therapy for hemophilia A. Nat Med. 2022 04; 28(4):789-797. Fong S, Yates B, Sihn CR, Mattis AN, Mitchell N, Liu S, Russell CB, Kim B, Lawal A, Rangarajan S, Lester W, Bunting S, Pierce GF, Pasi KJ, Wong WY. PMID: 35411075; PMCID: PMC9018415.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    15. Nonampullary Duodenal Adenomas in Familial Adenomatous Polyposis and Sporadic Patients Lack the DNA Content Abnormality That Is Characteristic of the Adenoma-Carcinoma Sequence Involved in the Development of Other Gastrointestinal Malignancies. Am J Surg Pathol. 2021 12 01; 45(12):1694-1702. Mohammed N, Rabinovitch PS, Wang D, Kovári BP, Mattis AN, Lauwers GY, Choi WT. PMID: 34138799.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    16. Doxycycline Significantly Enhances Induction of Induced Pluripotent Stem Cells to Endoderm by Enhancing Survival Through Protein Kinase B Phosphorylation. Hepatology. 2021 10; 74(4):2102-2117. Peaslee C, Esteva-Font C, Su T, Munoz-Howell A, Duwaerts CC, Liu Z, Rao S, Liu K, Medina M, Sneddon JB, Maher JJ, Mattis AN. PMID: 33982322; PMCID: PMC8544023.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    17. Gastric Intestinal Metaplasia in Mucosa Adjacent to Gastric Cancers Is Rarely Associated With the Aneuploidy That Is Characteristic of Gastric Dysplasia or Cancer. Am J Surg Pathol. 2021 10 01; 45(10):1374-1381. Zhang R, Rabinovitch PS, Mattis AN, Lauwers GY, Choi WT. PMID: 34091484.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    18. Persistent or recurrent Barrett's neoplasia after an endoscopic therapy session is associated with DNA content abnormality and can be detected by DNA flow cytometric analysis of paraffin-embedded tissue. Mod Pathol. 2021 10; 34(10):1889-1900. Bowman CJ, Zhang R, Balitzer D, Wang D, Rabinovitch PS, Kovári BP, Mattis AN, Kakar S, Lauwers GY, Choi WT. PMID: 34108638; PMCID: PMC8443444.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    19. Induced Pluripotent Stem Cell-derived Hepatocytes From Patients With Nonalcoholic Fatty Liver Disease Display a Disease-specific Gene Expression Profile. Gastroenterology. 2021 06; 160(7):2591-2594.e6. Duwaerts CC, Le Guillou D, Her CL, Phillips NJ, Willenbring H, Mattis AN, Maher JJ. PMID: 33640436; PMCID: PMC8169560.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    20. Non-conventional dysplasia in inflammatory bowel disease is more frequently associated with advanced neoplasia and aneuploidy than conventional dysplasia. Histopathology. 2021 May; 78(6):814-830. Lee H, Rabinovitch PS, Mattis AN, Lauwers GY, Choi WT. PMID: 33155325.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    21. Hepatocyte-specific deletion of XBP1 sensitizes mice to liver injury through hyperactivation of IRE1α. Cell Death Differ. 2021 05; 28(5):1455-1465. Duwaerts CC, Siao K, Soon RK, Her C, Iwawaki T, Kohno K, Mattis AN, Maher JJ. PMID: 33219328; PMCID: PMC8166833.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    22. Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice. Sci Transl Med. 2020 08 19; 12(557). Alsamman S, Christenson SA, Yu A, Ayad NME, Mooring MS, Segal JM, Hu JK, Schaub JR, Ho SS, Rao V, Marlow MM, Turner SM, Sedki M, Pantano L, Ghoshal S, Ferreira DDS, Ma HY, Duwaerts CC, Espanol-Suner R, Wei L, Newcomb B, Mileva I, Canals D, Hannun YA, Chung RT, Mattis AN, Fuchs BC, Tager AM, Yimlamai D, Weaver VM, Mullen AC, Sheppard D, Chen JY. PMID: 32817366; PMCID: PMC7976849.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    23. Ly6cLo non-classical monocytes promote resolution of rhesus rotavirus-mediated perinatal hepatic inflammation. Sci Rep. 2020 04 28; 10(1):7165. Alkhani A, Levy CS, Tsui M, Rosenberg KA, Polovina K, Mattis AN, Mack M, Van Dyken S, Wang BM, Maher JJ, Nijagal A. PMID: 32346042; PMCID: PMC7188847.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    24. Utility of DNA flow cytometry in distinguishing between malignant and benign intrahepatic biliary lesions. Virchows Arch. 2020 Oct; 477(4):527-534. Wen KW, Rabinovitch PS, Wang D, Mattis AN, Ferrell LD, Choi WT. PMID: 32296928; PMCID: PMC7954226.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    25. DNA flow cytometric analysis of paraffin-embedded tissue for the diagnosis of malignancy in bile duct biopsies. Hum Pathol. 2020 05; 99:80-87. Lee H, Rabinovitch PS, Mattis AN, Kakar S, Choi WT. PMID: 32272125; PMCID: PMC7997049.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    26. De novo somatic mutations and KRAS amplification are associated with cholangiocarcinoma in a patient with a history of choledochal cyst. J Pediatr Surg. 2020 Dec; 55(12):2657-2661. Schwab ME, Song H, Mattis A, Phelps A, Vu LT, Huang FW, Nijagal A. PMID: 32295706; PMCID: PMC7942710.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    27. Adipocyte JAK2 mediates spontaneous metabolic liver disease and hepatocellular carcinoma. JCI Insight. 2019 08 08; 5. Corbit KC, Wilson CG, Lowe D, Tran JL, Vera NB, Clasquin M, Mattis AN, Weiss EJ. PMID: 31393852; PMCID: PMC6777921.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    28. Diagnosis, risk stratification, and management of ampullary dysplasia by DNA flow cytometric analysis of paraffin-embedded tissue. Mod Pathol. 2019 09; 32(9):1291-1302. Wen KW, Kim GE, Rabinovitch PS, Wang D, Mattis AN, Choi WT. PMID: 30976103; PMCID: PMC8549479.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    29. Evaluation of commonly used ectoderm markers in iPSC trilineage differentiation. Stem Cell Res. 2019 05; 37:101434. Kuang YL, Munoz A, Nalula G, Santostefano KE, Sanghez V, Sanchez G, Terada N, Mattis AN, Iacovino M, Iribarren C, Krauss RM, Medina MW. PMID: 30999275; PMCID: PMC6570500.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    30. Utility of DNA Flow Cytometric Analysis of Paraffin-embedded Tissue in the Risk Stratification and Management of 'Indefinite for dysplasia' in Patients With Inflammatory Bowel Disease. J Crohns Colitis. 2019 Mar 30; 13(4):472-481. Wen KW, Rabinovitch PS, Wang D, Huang D, Mattis AN, Choi WT. PMID: 30423034.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    31. Depletion of murine fetal hematopoietic stem cells with c-Kit receptor and CD47 blockade improves neonatal engraftment. Blood Adv. 2018 12 26; 2(24):3602-3607. Witt RG, Wang B, Nguyen QH, Eikani C, Mattis AN, MacKenzie TC. PMID: 30567724; PMCID: PMC6306881.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    32. DNA content analysis of colorectal serrated lesions detects an aneuploid subset of inflammatory bowel disease-associated serrated epithelial change and traditional serrated adenomas. Histopathology. 2018 Sep; 73(3):464-472. Choi WT, Wen KW, Rabinovitch PS, Huang D, Mattis AN, Gill RM. PMID: 29772067.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    33. Use of DNA flow cytometry in the diagnosis, risk stratification, and management of gastric epithelial dysplasia. Mod Pathol. 2018 10; 31(10):1578-1587. Wen KW, Rabinovitch PS, Huang D, Mattis AN, Lauwers GY, Choi WT. PMID: 29789650.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    34. De novo formation of the biliary system by TGFβ-mediated hepatocyte transdifferentiation. Nature. 2018 05; 557(7704):247-251. Schaub JR, Huppert KA, Kurial SNT, Hsu BY, Cast AE, Donnelly B, Karns RA, Chen F, Rezvani M, Luu HY, Mattis AN, Rougemont AL, Rosenthal P, Huppert SS, Willenbring H. PMID: 29720662; PMCID: PMC6597492.
      View in: PubMed   Mentions: 102     Fields:    Translation:HumansAnimalsCells
    35. CD18 deficiency improves liver injury in the MCD model of steatohepatitis. PLoS One. 2017; 12(9):e0183912. Pierce AA, Duwaerts CC, Siao K, Mattis AN, Goodsell A, Baron JL, Maher JJ. PMID: 28873429; PMCID: PMC5584926.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    36. Association of Aneuploidy and Flat Dysplasia With Development of High-Grade Dysplasia or Colorectal Cancer in Patients With Inflammatory Bowel Disease. Gastroenterology. 2017 12; 153(6):1492-1495.e4. Tsai JH, Rabinovitch PS, Huang D, Small T, Mattis AN, Kakar S, Choi WT. PMID: 28843957.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    37. Diagnosis and risk stratification of Barrett's dysplasia by flow cytometric DNA analysis of paraffin-embedded tissue. Gut. 2018 07; 67(7):1229-1238. Choi WT, Tsai JH, Rabinovitch PS, Small T, Huang D, Mattis AN, Kakar S. PMID: 28642331.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    38. Diffusion-weighted imaging of hyperpolarized [13 C]urea in mouse liver. J Magn Reson Imaging. 2018 01; 47(1):141-151. Marco-Rius I, Gordon JW, Mattis AN, Bok R, Delos Santos R, Sukumar S, Larson PEZ, Vigneron DB, Ohliger MA. PMID: 28419644; PMCID: PMC5645231.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    39. A Novel Tumor-Activated Prodrug Strategy Targeting Ferrous Iron Is Effective in Multiple Preclinical Cancer Models. J Med Chem. 2016 12 22; 59(24):11161-11170. Spangler B, Fontaine SD, Shi Y, Sambucetti L, Mattis AN, Hann B, Wells JA, Renslo AR. PMID: 27936709; PMCID: PMC5184369.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    40. Heightened Immune Activation in Fetuses with Gastroschisis May Be Blocked by Targeting IL-5. J Immunol. 2016 06 15; 196(12):4957-66. Frascoli M, Jeanty C, Fleck S, Moradi PW, Keating S, Mattis AN, Tang Q, MacKenzie TC. PMID: 27183609; PMCID: PMC4977025.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    41. Human stem cells from single blastomeres reveal pathways of embryonic or trophoblast fate specification. Development. 2015 Dec 01; 142(23):4010-25. Zdravkovic T, Nazor KL, Larocque N, Gormley M, Donne M, Hunkapillar N, Giritharan G, Bernstein HS, Wei G, Hebrok M, Zeng X, Genbacev O, Mattis A, McMaster MT, Krtolica A, Valbuena D, Simón C, Laurent LC, Loring JF, Fisher SJ. PMID: 26483210; PMCID: PMC4712832.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    42. A screen in mice uncovers repression of lipoprotein lipase by microRNA-29a as a mechanism for lipid distribution away from the liver. Hepatology. 2015 Jan; 61(1):141-52. Mattis AN, Song G, Hitchner K, Kim RY, Lee AY, Sharma AD, Malato Y, McManus MT, Esau CC, Koller E, Koliwad S, Lim LP, Maher JJ, Raffai RL, Willenbring H. PMID: 25131933; PMCID: PMC4465779.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    43. Mouse liver repopulation with hepatocytes generated from human fibroblasts. Nature. 2014 Apr 03; 508(7494):93-7. Zhu S, Rezvani M, Harbell J, Mattis AN, Wolfe AR, Benet LZ, Willenbring H, Ding S. PMID: 24572354; PMCID: PMC4161230.
      View in: PubMed   Mentions: 132     Fields:    Translation:HumansAnimalsCells
    44. A ZFN/piggyBac step closer to autologous liver cell therapy. Hepatology. 2012 Jun; 55(6):2033-5. Mattis AN, Willenbring H. PMID: 22422378.
      View in: PubMed   Mentions: 1     Fields:    
    45. Expression of glypican-3 in undifferentiated embryonal sarcoma and mesenchymal hamartoma of the liver. Hum Pathol. 2012 May; 43(5):695-701. Levy M, Trivedi A, Zhang J, Miles L, Mattis AN, Kim GE, Lassman C, Anders RA, Misdraji J, Yerian LM, Xu H, Dhall D, Wang HL. PMID: 21937079; PMCID: PMC3568522.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    46. Clinical diagnosis of segmental arterial mediolysis: differentiation from vasculitis and other mimics. Arthritis Care Res (Hoboken). 2010 Nov; 62(11):1655-60. Baker-LePain JC, Stone DH, Mattis AN, Nakamura MC, Fye KH. PMID: 20662047; PMCID: PMC2974779.
      View in: PubMed   Mentions: 45     Fields:    Translation:Humans
    47. Purification and characterization of bacteriophage P22 Xis protein. J Bacteriol. 2008 Sep; 190(17):5781-96. Mattis AN, Gumport RI, Gardner JF. PMID: 18502866; PMCID: PMC2519534.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    48. IntDOT interactions with core- and arm-type sites of the conjugative transposon CTnDOT. J Bacteriol. 2007 Apr; 189(7):2692-701. Dichiara JM, Mattis AN, Gardner JF. PMID: 17277054; PMCID: PMC1855790.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    49. Integration host factor: putting a twist on protein-DNA recognition. J Mol Biol. 2003 Jul 11; 330(3):493-502. Lynch TW, Read EK, Mattis AN, Gardner JF, Rice PA. PMID: 12842466.
      View in: PubMed   Mentions: 35     Fields:    Translation:Cells
    50. 20q13.2 amplification in intraductal hyperplasia adjacent to in situ and invasive ductal carcinoma of the breast. Virchows Arch. 1999 Nov; 435(5):469-72. Werner M, Mattis A, Aubele M, Cummings M, Zitzelsberger H, Hutzler P, Höfler H. PMID: 10592049.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
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