Hideho Okada, MD, PhD

Title(s)Professor, Neurological Surgery
SchoolSchool of Medicine
Address1450 3rd Street, #472
San Francisco CA 94158
Phone415-476-1637
ORCID ORCID Icon0000-0003-0076-9920 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Nagoya University M.D.1991School of Medicine
    Nagoya University Ph.D.1996School of Medicine
    University of California, San Francisco, CA2019Diversity, Equity, and Inclusion Champion Training
    Collapse Awards and Honors
    Uehara Memorial Foundation 1996  - 1997Postdoctoral Scholarship
    Doris Duke Charitable Foundation 2001  - 2006Clinical Scientist Development Award
    James S. McDonnell’s Foundation2003  - 200721st Century Scientist Award
    Journal of Translational Medicine2006  - 2007Excellence in Translational Medicine Award
    University of Pittsburgh 2008Innovator Award
    University of Pittsburgh2009Faculty Honoree at the Annual Convocation
    American Society for Clinical Investigation (ASCI)2010Selected to be a Member
    Society for Immunotherapy for Cancer 2010Team Science Recognition Award
    University of Pittsburgh2011Faculty Honoree at the Annual Convocation
    University of Pittsburgh 2012Innovator Award
    University of Pittsburgh2013Faculty Honoree at the Annual Convocation
    University of Pittsburgh2014Faculty Honoree at the Annual Convocation

    Collapse Overview 
    Collapse Overview
    Dr. Okada is a creative physician-scientist who has developed therapeutic modalities in the laboratory, translated them into clinical protocols, and used his expertise as both scientist and clinician to assess the clinical data from ongoing trials. Dr. Okada's work has consistently focused on immunotherapeutic strategies aimed at a daunting challenge in oncology – malignant brain tumors. Dr. Okada conducted one of the first immune gene therapy trials in patients with malignant glioma. Dr. Okada's success in navigating the detailed regulatory processes that such trials require demonstrates his attention to detail and breadth of knowledge from basic science to clinical care. Dr. Okada's lab work was the first to identify and fully characterize cytotoxic T-lymphocyte (CTL) epitopes for gliomas. Dr. Okada's seminal discovery of CTL epitopes in glioma-associated antigens and the work on the mechanisms underlying the adjuvant effects of poly-ICLC enabled him to launch novel glioma vaccine trials in combination with poly-ICLC as an adjuvant. These efforts have also been supported by his mechanistic studies delineating the role of an integrin receptor very late activation antigen (VLA)-4 and chemokine CXCL10 in efficient trafficking of T-cells to brain tumor sites. Dr. Okada has held 4 Investigational New Drug approvals for his own vaccine trials. Since 2004 to 2014, Dr. Okada served as a Co-Leader of the Brain Tumor Program within the University of Pittsburgh Cancer Institute and has worked to expand the program by developing strong interdisciplinary and translational research activities among program members. In 2010, Dr. Okada was selected to be a member of the American Society for Clinical Investigation, which is an honor society of physician-scientists, those who translate findings in the laboratory to the advancement of clinical practice.

    Collapse Research 
    Collapse Research Activities and Funding
    Pilot randomized neoadjuvant vaccine with CD27-costimulation in low-grade glioma
    NIH R21CA233856Feb 14, 2019 - Jan 31, 2021
    Role: Principal Investigator
    Glioma immunotherapy targeting IDH mutation-derived epitope and immunosuppression
    NIH R01CA222965Jul 1, 2018 - Jun 30, 2023
    Role: Principal Investigator
    Preclinical development of breakthrough immunotherapy for brain tumors
    NIH R35NS105068Dec 15, 2017 - Nov 30, 2025
    Role: Principal Investigator
    Novel K27M Mutation-derived Neoantigen for T Cell Therapy in Gliomas
    NIH R01NS096954May 15, 2016 - Mar 31, 2021
    Role: Principal Investigator
    Antigens for Molecularly Targeted Vaccines for Progressive Glioma
    NIH R21NS093654Jul 1, 2015 - Jun 30, 2018
    Role: Principal Investigator
    Phase I Vaccine Study using Brain Tumor Initiating Cells in WHO Grade II Gliomas
    NIH R21CA177787Sep 25, 2014 - Aug 31, 2017
    Role: Principal Investigator
    Novel adoptive transfer therapy for glioma using CAR-transduced Type17 T-cells
    NIH R21NS083171Sep 15, 2014 - Aug 31, 2017
    Role: Principal Investigator
    Peptide-Based Vaccine Therapy for Childhood Malignant Gliomas
    NIH R21CA149872Mar 1, 2010 - Feb 28, 2013
    Role: Co-Principal Investigator
    A Bi-Institutional Pilot Study of Vaccinations for Patients with Low Grade Glioma
    NIH R21CA133859Jul 1, 2009 - Jun 30, 2012
    Role: Principal Investigator
    Directing Tumor-specific T cells to Tumors
    NIH P01CA132714Apr 27, 2009 - Mar 31, 2014
    Role: Co-Investigator
    Vaccination With Peptide-loaded alphaDC1s For Malignant Gliomas
    NIH R21CA117152Jan 1, 2007 - Dec 31, 2009
    Role: Principal Investigator
    Novel Immunotherapy of Glioma using miR-17-92 Transfected T Cells
    NIH R01NS055140Apr 1, 2006 - Jan 31, 2017
    Role: Principal Investigator
    Cytokine Gene Therapy of Cancer - Preclinical Studies
    NIH P01CA100327May 23, 2005 - Mar 31, 2011
    Role: Co-Investigator
    Novel Strategies for Brain Tumor Therapy
    NIH P01NS040923Dec 1, 2000 - Feb 28, 2014
    Role: Co-Investigator
    General Clinical Research Center
    NIH M01RR000056Dec 1, 1978 - Mar 31, 2009
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Challenges in the discovery of tumor-specific alternative splicing-derived cell-surface antigens in glioma. Sci Rep. 2024 03 16; 14(1):6362. Nejo T, Wang L, Leung KK, Wang A, Lakshmanachetty S, Gallus M, Kwok DW, Hong C, Chen LH, Carrera DA, Zhang MY, Stevers NO, Maldonado GC, Yamamichi A, Watchmaker PB, Naik A, Shai A, Phillips JJ, Chang SM, Wiita AP, Wells JA, Costello JF, Diaz AA, Okada H. PMID: 38493204; PMCID: PMC10944514.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. Absence of Stat1 in donor CD4+ T cells promotes the expansion of Tregs and reduces graft-versus-host disease in mice. J Clin Invest. 2024 Mar 01; 134(5). Ma H, Lu C, Ziegler J, Liu A, Sepulveda A, Okada H, Lentzsch S, Mapara MY. PMID: 38426505; PMCID: PMC10904050.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. Enhancing CAR-T cell metabolism to overcome hypoxic conditions in the brain tumor microenvironment. JCI Insight. 2024 Feb 22. Hatae R, Kyewalabye K, Yamamichi A, Chen T, Phyu S, Chuntova P, Nejo T, Levine LS, Spitzer MH, Okada H. PMID: 38386420.
      View in: PubMed   Mentions:    Fields:    
    4. A combinatory vaccine with IMA950 plus varlilumab promotes effector memory T-cell differentiation in the peripheral blood of patients with low-grade gliomas. Neuro Oncol. 2024 02 02; 26(2):335-347. Saijo A, Ogino H, Butowski NA, Tedesco MR, Gibson D, Watchmaker PB, Okada K, Wang AS, Shai A, Salazar AM, Molinaro AM, Rabbitt JE, Shahin M, Perry A, Clarke JL, Taylor JW, Daras M, Oberheim Bush NA, Hervey-Jumper SL, Phillips JJ, Chang SM, Hilf N, Mayer-Mokler A, Keler T, Berger MS, Okada H. PMID: 37758193; PMCID: PMC10836773.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. Glioblastoma evolution and heterogeneity from a 3D whole-tumor perspective. Cell. 2024 01 18; 187(2):446-463.e16. Mathur R, Wang Q, Schupp PG, Nikolic A, Hilz S, Hong C, Grishanina NR, Kwok D, Stevers NO, Jin Q, Youngblood MW, Stasiak LA, Hou Y, Wang J, Yamaguchi TN, Lafontaine M, Shai A, Smirnov IV, Solomon DA, Chang SM, Hervey-Jumper SL, Berger MS, Lupo JM, Okada H, Phillips JJ, Boutros PC, Gallo M, Oldham MC, Yue F, Costello JF. PMID: 38242087; PMCID: PMC10832360.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    6. Glioblastoma vaccines: past, present, and opportunities. EBioMedicine. 2024 Feb; 100:104963. Xiong Z, Raphael I, Olin M, Okada H, Li X, Kohanbash G. PMID: 38183840; PMCID: PMC10808938.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    7. Correction: Gallus et al. Immunotherapy Approaches in Isocitrate-Dehydrogenase-Mutant Low-Grade Glioma. Cancers 2023, 15, 3726. Cancers (Basel). 2023 Dec 26; 16(1). Gallus M, Kwok D, Lakshmanachetty S, Yamamichi A, Okada H. PMID: 38201665; PMCID: PMC10778241.
      View in: PubMed   Mentions:
    8. A road map for the treatment of pediatric diffuse midline glioma. Cancer Cell. 2024 01 08; 42(1):1-5. Koschmann C, Al-Holou WN, Alonso MM, Anastas J, Bandopadhayay P, Barron T, Becher O, Cartaxo R, Castro MG, Chung C, Clausen M, Dang D, Doherty R, Duchatel R, Dun M, Filbin M, Franson A, Galban S, Garcia Moure M, Garton H, Gowda P, Marques JG, Hawkins C, Heath A, Hulleman E, Ji S, Jones C, Kilburn L, Kline C, Koldobskiy MA, Lim D, Lowenstein PR, Lu QR, Lum J, Mack S, Magge S, Marini B, Martin D, Marupudi N, Messinger D, Mody R, Morgan M, Mota M, Muraszko K, Mueller S, Natarajan SK, Nazarian J, Niculcea M, Nuechterlein N, Okada H, Opipari V, Pai MP, Pal S, Peterson E, Phoenix T, Prensner JR, Pun M, Raju GP, Reitman ZJ, Resnick A, Rogawski D, Saratsis A, Sbergio SG, Souweidane M, Stafford JM, Tzaridis T, Venkataraman S, Vittorio O, Wadden J, Wahl D, Wechsler-Reya RJ, Yadav VN, Zhang X, Zhang Q, Venneti S. PMID: 38039965.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    9. Enhancing CAR-T Cell Metabolism to Overcome Hypoxic Conditions in the Brain Tumor Microenvironment. bioRxiv. 2023 Nov 15. Hatae R, Kyewalabye K, Yamamichi A, Chen T, Phyu S, Chuntova P, Nejo T, Levine LS, Spitzer MH, Okada H. PMID: 38014236; PMCID: PMC10680638.
      View in: PubMed   Mentions:
    10. Challenges in the discovery of tumor-specific alternative splicing-derived cell-surface antigens in glioma. bioRxiv. 2023 Nov 02. Nejo T, Wang L, Leung KK, Wang A, Lakshmanachetty S, Gallus M, Kwok DW, Hong C, Chen LH, Carrera DA, Zhang MY, Stevers NO, Maldonado GC, Yamamichi A, Watchmaker P, Naik A, Shai A, Phillips JJ, Chang SM, Wiita AP, Wells JA, Costello JF, Diaz AA, Okada H. PMID: 37961484; PMCID: PMC10634890.
      View in: PubMed   Mentions:
    11. Quantitative analysis of MGMT promoter methylation in glioblastoma suggests nonlinear prognostic effect. Neurooncol Adv. 2023 Jan-Dec; 5(1):vdad115. Gibson D, Ravi A, Rodriguez E, Chang S, Oberheim Bush N, Taylor J, Clarke J, Solomon D, Scheffler A, Witte J, Lambing H, Okada H, Berger M, Chehab F, Butowski NA. PMID: 37899778; PMCID: PMC10611422.
      View in: PubMed   Mentions: 2  
    12. Sex-Biased T-cell Exhaustion Drives Differential Immune Responses in Glioblastoma. Cancer Discov. 2023 09 06; 13(9):2090-2105. Lee J, Nicosia M, Hong ES, Silver DJ, Li C, Bayik D, Watson DC, Lauko A, Kay KE, Wang SZ, Johnson S, McGraw M, Grabowski MM, Kish DD, Desai AB, Goodman WA, Cameron SJ, Okada H, Valujskikh A, Fairchild RL, Ahluwalia MS, Lathia JD. PMID: 37378557; PMCID: PMC10481130.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    13. Glioma-neuronal circuit remodeling induces regional immunosuppression. bioRxiv. 2023 Aug 06. Nejo T, Krishna S, Jimenez C, Yamamichi A, Young JS, Lakshmanachetty S, Chen T, Phyu SSS, Ogino H, Watchmaker P, Diebold D, Choudhury A, Daniel AGS, Raleigh DR, Hervey-Jumper SL, Okada H. PMID: 37577659; PMCID: PMC10418167.
      View in: PubMed   Mentions:
    14. Immunotherapy Approaches in Isocitrate-Dehydrogenase-Mutant Low-Grade Glioma. Cancers (Basel). 2023 Jul 22; 15(14). Gallus M, Kwok D, Lakshmanachetty S, Yamamichi A, Okada H. PMID: 37509387; PMCID: PMC10378701.
      View in: PubMed   Mentions: 1  
    15. Translational imaging of TSPO reveals pronounced innate inflammation in human and murine CD8 T cell-mediated limbic encephalitis. Sci Adv. 2023 06 09; 9(23):eabq7595. Gallus M, Roll W, Dik A, Barca C, Zinnhardt B, Hicking G, Mueller C, Naik VN, Anstötz M, Krämer J, Rolfes L, Wachsmuth L, Pitsch J, van Loo KMJ, Räuber S, Okada H, Wimberley C, Strippel C, Golombeck KS, Johnen A, Kovac S, Groß CC, Backhaus P, Seifert R, Lewerenz J, Surges R, Elger CE, Wiendl H, Ruck T, Becker AJ, Faber C, Jacobs AH, Bauer J, Meuth SG, Schäfers M, Melzer N. PMID: 37294768; PMCID: PMC10256169.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    16. Correspondence on 'H3.3K27M mutation is not a suitable target for immunotherapy in HLA-A2+ patients with diffuse midline glioma' by Immisch et al. J Immunother Cancer. 2023 03; 11(3). Chheda ZS, Mueller S, Hegde B, Yamamichi A, Butterfield LH, Okada H. PMID: 36944450; PMCID: PMC10032395.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    17. Magnetic Resonance Spectroscopy Metabolites as Biomarkers of Disease Status in Pediatric Diffuse Intrinsic Pontine Gliomas (DIPG) Treated with Glioma-Associated Antigen Peptide Vaccines. Cancers (Basel). 2022 Dec 05; 14(23). Panigrahy A, Jakacki RI, Pollack IF, Ceschin R, Okada H, Nelson MD, Kohanbash G, Dhall G, Bluml S. PMID: 36497477.
      View in: PubMed   Mentions: 1  
    18. RASA2 ablation in T cells boosts antigen sensitivity and long-term function. Nature. 2022 09; 609(7925):174-182. Carnevale J, Shifrut E, Kale N, Nyberg WA, Blaeschke F, Chen YY, Li Z, Bapat SP, Diolaiti ME, O'Leary P, Vedova S, Belk J, Daniel B, Roth TL, Bachl S, Anido AA, Prinzing B, Ibañez-Vega J, Lange S, Haydar D, Luetke-Eversloh M, Born-Bony M, Hegde B, Kogan S, Feuchtinger T, Okada H, Satpathy AT, Shannon K, Gottschalk S, Eyquem J, Krenciute G, Ashworth A, Marson A. PMID: 36002574; PMCID: PMC9433322.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    19. Antigen-Dependent Inducible T-Cell Reporter System for PET Imaging of Breast Cancer and Glioblastoma. J Nucl Med. 2023 01; 64(1):137-144. Shin J, Parker MFL, Zhu I, Alanizi A, Rodriguez CI, Liu R, Watchmaker PB, Kalita M, Blecha J, Luu J, Wright B, Lapi SE, Flavell RR, Okada H, Tlsty TD, Roybal KT, Wilson DM. PMID: 35981900; PMCID: PMC9841254.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    20. Future development of chimeric antigen receptor T cell therapies for patients suffering from malignant glioma. Curr Opin Oncol. 2022 11 01; 34(6):661-669. Watchmaker PB, Colton M, Pineo-Cavanaugh PL, Okada H. PMID: 35855503; PMCID: PMC9560977.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    21. Mass cytometry detects H3.3K27M-specific vaccine responses in diffuse midline glioma. J Clin Invest. 2022 06 15; 132(12). Mueller S, Taitt JM, Villanueva-Meyer JE, Bonner ER, Nejo T, Lulla RR, Goldman S, Banerjee A, Chi SN, Whipple NS, Crawford JR, Gauvain K, Nazemi KJ, Watchmaker PB, Almeida ND, Okada K, Salazar AM, Gilbert RD, Nazarian J, Molinaro AM, Butterfield LH, Prados MD, Okada H. PMID: 35703183; PMCID: PMC9203080.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    22. The future of cancer immunotherapy for brain tumors: a collaborative workshop. J Transl Med. 2022 05 23; 20(1):236. Brown CE, Bucktrout S, Butterfield LH, Futer O, Galanis E, Hormigo A, Lim M, Okada H, Prins R, Marr SS, Tanner K. PMID: 35606815; PMCID: PMC9125824.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    23. Inhibition of D-2HG leads to upregulation of a proinflammatory gene signature in a novel HLA-A2/HLA-DR1 transgenic mouse model of IDH1R132H-expressing glioma. J Immunother Cancer. 2022 05; 10(5). Chuntova P, Yamamichi A, Chen T, Narayanaswamy R, Ronseaux S, Hudson C, Tron AE, Hyer ML, Montoya M, Mende AL, Nejo T, Downey KM, Diebold D, Lu M, Nicolay B, Okada H. PMID: 35606087; PMCID: PMC9174833.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    24. The immunology of low-grade gliomas. Neurosurg Focus. 2022 02; 52(2):E2. Haddad AF, Young JS, Oh JY, Okada H, Aghi MK. PMID: 35104791; PMCID: PMC9283531.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    25. Novel EGFRvIII-CAR transgenic mice for rigorous preclinical studies in syngeneic mice. Neuro Oncol. 2022 02 01; 24(2):259-272. Chuntova P, Hou Y, Naka R, Yamamichi A, Chen T, Goretsky Y, Hatae R, Nejo T, Kohanbash G, Mende AL, Montoya M, Downey KM, Diebold D, Skinner J, Liang HE, Schwer B, Okada H. PMID: 34347086; PMCID: PMC8804899.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    26. Randomized trial of neoadjuvant vaccination with tumor-cell lysate induces T cell response in low-grade gliomas. J Clin Invest. 2022 02 01; 132(3). Ogino H, Taylor JW, Nejo T, Gibson D, Watchmaker PB, Okada K, Saijo A, Tedesco MR, Shai A, Wong CM, Rabbitt JE, Olin MR, Moertel CL, Nishioka Y, Salazar AM, Molinaro AM, Phillips JJ, Butowski NA, Clarke JL, Oberheim Bush NA, Hervey-Jumper SL, Theodosopoulos P, Chang SM, Berger MS, Okada H. PMID: 34882581; PMCID: PMC8803342.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCellsPHPublic Health
    27. The current landscape of immunotherapy for pediatric brain tumors. Nat Cancer. 2022 01; 3(1):11-24. Hwang EI, Sayour EJ, Flores CT, Grant G, Wechsler-Reya R, Hoang-Minh LB, Kieran MW, Salcido J, Prins RM, Figg JW, Platten M, Candelario KM, Hale PG, Blatt JE, Governale LS, Okada H, Mitchell DA, Pollack IF. PMID: 35121998.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    28. Deep immune profiling reveals targetable mechanisms of immune evasion in immune checkpoint inhibitor-refractory glioblastoma. J Immunother Cancer. 2021 06; 9(6). Simonds EF, Lu ED, Badillo O, Karimi S, Liu EV, Tamaki W, Rancan C, Downey KM, Stultz J, Sinha M, McHenry LK, Nasholm NM, Chuntova P, Sundström A, Genoud V, Shahani SA, Wang LD, Brown CE, Walker PR, Swartling FJ, Fong L, Okada H, Weiss WA, Hellström M. PMID: 34083417; PMCID: PMC8183210.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    29. IFN-γ- and IL-17-producing CD8+ T (Tc17-1) cells in combination with poly-ICLC and peptide vaccine exhibit antiglioma activity. J Immunother Cancer. 2021 06; 9(6). Ohkuri T, Kosaka A, Ikeura M, Salazar AM, Okada H. PMID: 34193567; PMCID: PMC8246372.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    30. SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma. Sci Transl Med. 2021 04 28; 13(591). Choe JH, Watchmaker PB, Simic MS, Gilbert RD, Li AW, Krasnow NA, Downey KM, Yu W, Carrera DA, Celli A, Cho J, Briones JD, Duecker JM, Goretsky YE, Dannenfelser R, Cardarelli L, Troyanskaya O, Sidhu SS, Roybal KT, Okada H, Lim WA. PMID: 33910979; PMCID: PMC8362330.
      View in: PubMed   Mentions: 139     Fields:    Translation:AnimalsCells
    31. Unique challenges for glioblastoma immunotherapy-discussions across neuro-oncology and non-neuro-oncology experts in cancer immunology. Meeting Report from the 2019 SNO Immuno-Oncology Think Tank. Neuro Oncol. 2021 03 25; 23(3):356-375. Chuntova P, Chow F, Watchmaker PB, Galvez M, Heimberger AB, Newell EW, Diaz A, DePinho RA, Li MO, Wherry EJ, Mitchell D, Terabe M, Wainwright DA, Berzofsky JA, Herold-Mende C, Heath JR, Lim M, Margolin KA, Chiocca EA, Kasahara N, Ellingson BM, Brown CE, Chen Y, Fecci PE, Reardon DA, Dunn GP, Liau LM, Costello JF, Wick W, Cloughesy T, Timmer WC, Wen PY, Prins RM, Platten M, Okada H. PMID: 33367885; PMCID: PMC7992879.
      View in: PubMed   Mentions: 50     Fields:    Translation:Humans
    32. The evolution of alternative splicing in glioblastoma under therapy. Genome Biol. 2021 01 26; 22(1):48. Wang L, Shamardani K, Babikir H, Catalan F, Nejo T, Chang S, Phillips JJ, Okada H, Diaz AA. PMID: 33499924; PMCID: PMC7835670.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    33. Current Advances in Immunotherapy for Glioblastoma. Curr Oncol Rep. 2021 01 26; 23(2):21. Mende AL, Schulte JD, Okada H, Clarke JL. PMID: 33496872; PMCID: PMC7838142.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    34. Assessing Oximetry Response to Chimeric Antigen Receptor T-cell Therapy against Glioma with 19F MRI in a Murine Model. Radiol Imaging Cancer. 2021 01; 3(1):e200062. Chapelin F, Leach BI, Chen R, Lister D, Messer K, Okada H, Ahrens ET. PMID: 33575659; PMCID: PMC7850236.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    35. Zika virus oncolytic activity requires CD8+ T cells and is boosted by immune checkpoint blockade. JCI Insight. 2021 01 11; 6(1). Nair S, Mazzoccoli L, Jash A, Govero J, Bais SS, Hu T, Fontes-Garfias CR, Shan C, Okada H, Shresta S, Rich JN, Shi PY, Diamond MS, Chheda MG. PMID: 33232299; PMCID: PMC7821591.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    36. Considerations when treating high-grade pediatric glioma patients with immunotherapy. Expert Rev Neurother. 2021 02; 21(2):205-219. Crotty E, Downey K, Ferrerosa L, Flores C, Hegde B, Raskin S, Hwang E, Vitanza N, Okada H. PMID: 33225764; PMCID: PMC7880880.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    37. Mass cytometry detects H3.3K27M-specific vaccine responses in diffuse midline glioma. J Clin Invest. 2020 12 01; 130(12):6325-6337. Mueller S, Taitt JM, Villanueva-Meyer JE, Bonner ER, Nejo T, Lulla RR, Goldman S, Banerjee A, Chi SN, Whipple NS, Crawford JR, Gauvain K, Nazemi KJ, Watchmaker PB, Almeida ND, Okada K, Salazar AM, Gilbert RD, Nazarian J, Molinaro AM, Butterfield LH, Prados MD, Okada H. PMID: 32817593; PMCID: PMC7685729.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCellsCTClinical Trials
    38. The current state of immunotherapy for primary and secondary brain tumors: similarities and differences. Jpn J Clin Oncol. 2020 Oct 22; 50(11):1231-1245. Nejo T, Mende A, Okada H. PMID: 32984905; PMCID: PMC7733526.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    39. The Great Debate at 'Immunotherapy Bridge', Naples, December 5, 2019. J Immunother Cancer. 2020 08; 8(2). Ascierto PA, Bifulco C, Galon J, Garbe C, Khleif SN, McQuade J, Odunsi K, Okada H, Paulos CM, Quezada SA, Tawbi HA, Timmerman J, Trinchieri G, Butterfield LH, Puzanov I. PMID: 32843491; PMCID: PMC7449295.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    40. T-Cell based therapies for overcoming neuroanatomical and immunosuppressive challenges within the glioma microenvironment. J Neurooncol. 2020 Apr; 147(2):281-295. Kwok D, Okada H. PMID: 32185647; PMCID: PMC7182069.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    41. Introduction to immunotherapy for brain tumor patients: challenges and future perspectives. Neurooncol Pract. 2020 Oct; 7(5):465-476. Montoya ML, Kasahara N, Okada H. PMID: 33014387; PMCID: PMC7516091.
      View in: PubMed   Mentions: 9  
    42. Tumor antigens in glioma. Semin Immunol. 2020 02; 47:101385. Nejo T, Yamamichi A, Almeida ND, Goretsky YE, Okada H. PMID: 32037183.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    43. Genetically stable poliovirus vectors activate dendritic cells and prime antitumor CD8 T cell immunity. Nat Commun. 2020 Jan 27; 11(1):524. Mosaheb MM, Dobrikova EY, Brown MC, Yang Y, Cable J, Okada H, Nair SK, Bigner DD, Ashley DM, Gromeier M. PMID: 31988324; PMCID: PMC6985231.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
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    46. Cell penetrating peptide functionalized perfluorocarbon nanoemulsions for targeted cell labeling and enhanced fluorine-19 MRI detection. Magn Reson Med. 2020 03; 83(3):974-987. Hingorani DV, Chapelin F, Stares E, Adams SR, Okada H, Ahrens ET. PMID: 31631402; PMCID: PMC6879799.
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    47. Withdrawal: Identification of tumor antigens among the HLA peptidomes of glioblastoma tumors and plasma. Mol Cell Proteomics. 2019 Jun; 18(6):1270. Shraibman B, Barnea E, Kadosh DM, Haimovich Y, Slobodin G, Rosner I, López-Larrea C, Hilf N, Kuttruff S, Song C, Britten C, Castle J, Kreiter S, Frenzel K, Tatagiba M, Tabatabai G, Dietrich PY, Dutoit V, Wick W, Platten M, Winkler F, von Deimling A, Kroep J, Sahuquillo J, Martinez-Ricarte F, Rodon J, Lassen U, Ottensmeier C, van der Burg SH, Thor Straten P, Poulsen HS, Ponsati B, Okada H, Rammensee HG, Sahin U, Singh H, Admon A. PMID: 31154440; PMCID: PMC6553924.
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    52. Immunotherapy for High-Grade Gliomas: A Clinical Update and Practical Considerations for Neurosurgeons. World Neurosurg. 2019 Apr; 124:397-409. Young JS, Dayani F, Morshed RA, Okada H, Aghi MK. PMID: 30677574; PMCID: PMC6642850.
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    71. IDH mutant gliomas escape natural killer cell immune surveillance by downregulation of NKG2D ligand expression. Neuro Oncol. 2016 10; 18(10):1402-12. Zhang X, Rao A, Sette P, Deibert C, Pomerantz A, Kim WJ, Kohanbash G, Chang Y, Park Y, Engh J, Choi J, Chan T, Okada H, Lotze M, Grandi P, Amankulor N. PMID: 27116977; PMCID: PMC5035522.
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    74. The role of emerging therapy in the management of patients with diffuse low grade glioma. J Neurooncol. 2015 Dec; 125(3):631-5. Sloan AE, Okada H, Ryken TC, Kalkanis SN, Olson JJ. PMID: 26530260.
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    75. Immunotherapy response assessment in neuro-oncology: a report of the RANO working group. Lancet Oncol. 2015 Nov; 16(15):e534-e542. Okada H, Weller M, Huang R, Finocchiaro G, Gilbert MR, Wick W, Ellingson BM, Hashimoto N, Pollack IF, Brandes AA, Franceschi E, Herold-Mende C, Nayak L, Panigrahy A, Pope WB, Prins R, Sampson JH, Wen PY, Reardon DA. PMID: 26545842; PMCID: PMC4638131.
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    76. Principles of immunology and its nuances in the central nervous system. Neuro Oncol. 2015 Nov; 17 Suppl 7:vii3-vii8. Dunn GP, Okada H. PMID: 26516224; PMCID: PMC4625893.
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    77. Histamine deficiency promotes accumulation of immunosuppressive immature myeloid cells and growth of murine gliomas. Oncoimmunology. 2015 Nov; 4(11):e1047581. Ahn B, Kohanbash G, Ohkuri T, Kosaka A, Chen X, Ikeura M, Wang TC, Okada H. PMID: 26451324; PMCID: PMC4589044.
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    78. Exosomes isolated from plasma of glioma patients enrolled in a vaccination trial reflect antitumor immune activity and might predict survival. Oncoimmunology. 2015 Jun; 4(6):e1008347. Muller L, Muller-Haegele S, Mitsuhashi M, Gooding W, Okada H, Whiteside TL. PMID: 26155415; PMCID: PMC4485717.
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    79. Re-defining response and treatment effects for neuro-oncology immunotherapy clinical trials. J Neurooncol. 2015 Jul; 123(3):339-46. Reardon DA, Okada H. PMID: 25707876.
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    80. Rational development and characterization of humanized anti-EGFR variant III chimeric antigen receptor T cells for glioblastoma. Sci Transl Med. 2015 Feb 18; 7(275):275ra22. Johnson LA, Scholler J, Ohkuri T, Kosaka A, Patel PR, McGettigan SE, Nace AK, Dentchev T, Thekkat P, Loew A, Boesteanu AC, Cogdill AP, Chen T, Fraietta JA, Kloss CC, Posey AD, Engels B, Singh R, Ezell T, Idamakanti N, Ramones MH, Li N, Zhou L, Plesa G, Seykora JT, Okada H, June CH, Brogdon JL, Maus MV. PMID: 25696001; PMCID: PMC4467166.
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    81. Transgene-derived overexpression of miR-17-92 in CD8+ T-cells confers enhanced cytotoxic activity. Biochem Biophys Res Commun. 2015 Mar 13; 458(3):549-554. Kosaka A, Ohkuri T, Ikeura M, Kohanbash G, Okada H. PMID: 25677619; PMCID: PMC4355048.
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    82. Protective role of STING against gliomagenesis: Rational use of STING agonist in anti-glioma immunotherapy. Oncoimmunology. 2015 Apr; 4(4):e999523. Ohkuri T, Ghosh A, Kosaka A, Sarkar SN, Okada H. PMID: 26137417; PMCID: PMC4485761.
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    83. Classification of current anticancer immunotherapies. Oncotarget. 2014 Dec 30; 5(24):12472-508. Galluzzi L, Vacchelli E, Bravo-San Pedro JM, Buqué A, Senovilla L, Baracco EE, Bloy N, Castoldi F, Abastado JP, Agostinis P, Apte RN, Aranda F, Ayyoub M, Beckhove P, Blay JY, Bracci L, Caignard A, Castelli C, Cavallo F, Celis E, Cerundolo V, Clayton A, Colombo MP, Coussens L, Dhodapkar MV, Eggermont AM, Fearon DT, Fridman WH, Fucíková J, Gabrilovich DI, Galon J, Garg A, Ghiringhelli F, Giaccone G, Gilboa E, Gnjatic S, Hoos A, Hosmalin A, Jäger D, Kalinski P, Kärre K, Kepp O, Kiessling R, Kirkwood JM, Klein E, Knuth A, Lewis CE, Liblau R, Lotze MT, Lugli E, Mach JP, Mattei F, Mavilio D, Melero I, Melief CJ, Mittendorf EA, Moretta L, Odunsi A, Okada H, Palucka AK, Peter ME, Pienta KJ, Porgador A, Prendergast GC, Rabinovich GA, Restifo NP, Rizvi N, Sautès-Fridman C, Schreiber H, Seliger B, Shiku H, Silva-Santos B, Smyth MJ, Speiser DE, Spisek R, Srivastava PK, Talmadge JE, Tartour E, Van Der Burg SH, Van Den Eynde BJ, Vile R, Wagner H, Weber JS, Whiteside TL, Wolchok JD, Zitvogel L, Zou W, Kroemer G. PMID: 25537519; PMCID: PMC4350348.
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    84. CD200 in CNS tumor-induced immunosuppression: the role for CD200 pathway blockade in targeted immunotherapy. J Immunother Cancer. 2014; 2(1):46. Moertel CL, Xia J, LaRue R, Waldron NN, Andersen BM, Prins RM, Okada H, Donson AM, Foreman NK, Hunt MA, Pennell CA, Olin MR. PMID: 25598973; PMCID: PMC4296547.
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    87. Antigen-specific immune responses and clinical outcome after vaccination with glioma-associated antigen peptides and polyinosinic-polycytidylic acid stabilized by lysine and carboxymethylcellulose in children with newly diagnosed malignant brainstem and nonbrainstem gliomas. J Clin Oncol. 2014 Jul 01; 32(19):2050-8. Pollack IF, Jakacki RI, Butterfield LH, Hamilton RL, Panigrahy A, Potter DM, Connelly AK, Dibridge SA, Whiteside TL, Okada H. PMID: 24888813; PMCID: PMC4067943.
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    89. Expression of miR-17-92 enhances anti-tumor activity of T-cells transduced with the anti-EGFRvIII chimeric antigen receptor in mice bearing human GBM xenografts. J Immunother Cancer. 2013; 1:21. Ohno M, Ohkuri T, Kosaka A, Tanahashi K, June CH, Natsume A, Okada H. PMID: 24829757; PMCID: PMC4019893.
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    91. Ependymomas: development of immunotherapeutic strategies. Expert Rev Neurother. 2013 Oct; 13(10):1089-98. Pollack IF, Jakacki RI, Butterfield LH, Okada H. PMID: 24117271; PMCID: PMC3972122.
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    92. GM-CSF promotes the immunosuppressive activity of glioma-infiltrating myeloid cells through interleukin-4 receptor-α. Cancer Res. 2013 Nov 01; 73(21):6413-23. Kohanbash G, McKaveney K, Sakaki M, Ueda R, Mintz AH, Amankulor N, Fujita M, Ohlfest JR, Okada H. PMID: 24030977; PMCID: PMC3829000.
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    93. Peptide vaccine therapy for childhood gliomas. Neurosurgery. 2013 Aug; 60 Suppl 1:113-9. Pollack IF, Jakacki RI, Butterfield LH, Okada H. PMID: 23839362.
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    94. In vivo intracellular oxygen dynamics in murine brain glioma and immunotherapeutic response of cytotoxic T cells observed by fluorine-19 magnetic resonance imaging. PLoS One. 2013; 8(5):e59479. Zhong J, Sakaki M, Okada H, Ahrens ET. PMID: 23667419; PMCID: PMC3648573.
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    95. Integration of epidemiology, immunobiology, and translational research for brain tumors. Ann N Y Acad Sci. 2013 May; 1284:17-23. Okada H, Scheurer ME, Sarkar SN, Bondy ML. PMID: 23651189; PMCID: PMC3648859.
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    96. Premetastatic soil and prevention of breast cancer brain metastasis. Neuro Oncol. 2013 Jul; 15(7):891-903. Liu Y, Kosaka A, Ikeura M, Kohanbash G, Fellows-Mayle W, Snyder LA, Okada H. PMID: 23595625; PMCID: PMC3688013.
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    97. LOH in the HLA class I region at 6p21 is associated with shorter survival in newly diagnosed adult glioblastoma. Clin Cancer Res. 2013 Apr 01; 19(7):1816-26. Yeung JT, Hamilton RL, Ohnishi K, Ikeura M, Potter DM, Nikiforova MN, Ferrone S, Jakacki RI, Pollack IF, Okada H. PMID: 23401227; PMCID: PMC3618546.
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    98. Increased expression of tumor-associated antigens in pediatric and adult ependymomas: implication for vaccine therapy. J Neurooncol. 2013 Jan; 111(2):103-11. Yeung JT, Hamilton RL, Okada H, Jakacki RI, Pollack IF. PMID: 23179498; PMCID: PMC3546121.
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    99. Inhibition of Indoleamine-2,3-dioxygenase (IDO) in Glioblastoma Cells by Oncolytic Herpes Simplex Virus. Adv Virol. 2012; 2012:815465. Reinhart B, Mazzacurati L, Forero A, Hong CS, Eguchi J, Okada H, Fellows W, Niranjan A, Cohen JB, Glorioso JC, Grandi P. PMID: 22924042; PMCID: PMC3424635.
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    100. Differential activity of interferon-α8 promoter is regulated by Oct-1 and a SNP that dictates prognosis of glioma. Oncoimmunology. 2012 Jul 01; 1(4):487-492. Kohanbash G, Ishikawa E, Fujita M, Ikeura M, McKaveney K, Zhu J, Sakaki M, Sarkar SN, Okada H. PMID: 22754767; PMCID: PMC3382910.
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    101. Workshop on immunotherapy combinations. Society for Immunotherapy of Cancer annual meeting Bethesda, November 3, 2011. J Transl Med. 2012 May 28; 10:108. Martinez Forero I, Okada H, Topalian SL, Gajewski TF, Korman AJ, Melero I. PMID: 22640522; PMCID: PMC3404934.
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    102. Type17 T-cells in central nervous system autoimmunity and tumors. J Clin Immunol. 2012 Aug; 32(4):802-8. Okada H, Khoury SJ. PMID: 22454247; PMCID: PMC3389562.
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    103. Peptide-pulsed dendritic cell vaccination targeting interleukin-13 receptor α2 chain in recurrent malignant glioma patients with HLA-A*24/A*02 allele. Cytotherapy. 2012 Jul; 14(6):733-42. Iwami K, Shimato S, Ohno M, Okada H, Nakahara N, Sato Y, Yoshida J, Suzuki S, Nishikawa H, Shiku H, Natsume A, Wakabayashi T. PMID: 22424217.
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    104. Vaccines targeting tumor blood vessel antigens promote CD8(+) T cell-dependent tumor eradication or dormancy in HLA-A2 transgenic mice. J Immunol. 2012 Feb 15; 188(4):1782-8. Zhao X, Bose A, Komita H, Taylor JL, Chi N, Lowe DB, Okada H, Cao Y, Mukhopadhyay D, Cohen PA, Storkus WJ. PMID: 22246626; PMCID: PMC3273624.
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    105. Myeloid-derived suppressor cells (MDSCs) in gliomas and glioma-development. Immunol Invest. 2012; 41(6-7):658-79. Kohanbash G, Okada H. PMID: 23017140.
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    106. MicroRNAs and STAT interplay. Semin Cancer Biol. 2012 Feb; 22(1):70-5. Kohanbash G, Okada H. PMID: 22210182; PMCID: PMC3288787.
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    107. Expression of antigen processing and presenting molecules in brain metastasis of breast cancer. Cancer Immunol Immunother. 2012 Jun; 61(6):789-801. Liu Y, Komohara Y, Domenick N, Ohno M, Ikeura M, Hamilton RL, Horbinski C, Wang X, Ferrone S, Okada H. PMID: 22065046; PMCID: PMC3365630.
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    108. Dendritic cells in cancer immunotherapy: vaccines or autologous transplants? Immunol Res. 2011 Aug; 50(2-3):235-47. Kalinski P, Edington H, Zeh HJ, Okada H, Butterfield LH, Kirkwood JM, Bartlett DL. PMID: 21717071; PMCID: PMC3695396.
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    109. Absence of Stat1 in donor CD4⁺ T cells promotes the expansion of Tregs and reduces graft-versus-host disease in mice. J Clin Invest. 2011 Jul; 121(7):2554-69. Ma H, Lu C, Ziegler J, Liu A, Sepulveda A, Okada H, Lentzsch S, Mapara MY. PMID: 21670504; PMCID: PMC3223821.
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    110. Do we need novel radiologic response criteria for brain tumor immunotherapy? Expert Rev Neurother. 2011 May; 11(5):619-22. Okada H, Pollack IF. PMID: 21539483.
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    111. COX-2 blockade suppresses gliomagenesis by inhibiting myeloid-derived suppressor cells. Cancer Res. 2011 Apr 01; 71(7):2664-74. Fujita M, Kohanbash G, Fellows-Mayle W, Hamilton RL, Komohara Y, Decker SA, Ohlfest JR, Okada H. PMID: 21324923; PMCID: PMC3075086.
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    112. Induction of CD8+ T-cell responses against novel glioma-associated antigen peptides and clinical activity by vaccinations with {alpha}-type 1 polarized dendritic cells and polyinosinic-polycytidylic acid stabilized by lysine and carboxymethylcellulose in patients with recurrent malignant glioma. J Clin Oncol. 2011 Jan 20; 29(3):330-6. Okada H, Kalinski P, Ueda R, Hoji A, Kohanbash G, Donegan TE, Mintz AH, Engh JA, Bartlett DL, Brown CK, Zeh H, Holtzman MP, Reinhart TA, Whiteside TL, Butterfield LH, Hamilton RL, Potter DM, Pollack IF, Salazar AM, Lieberman FS. PMID: 21149657; PMCID: PMC3056467.
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    113. Systemic delivery of neutralizing antibody targeting CCL2 for glioma therapy. J Neurooncol. 2011 Aug; 104(1):83-92. Zhu X, Fujita M, Snyder LA, Okada H. PMID: 21116835; PMCID: PMC3068234.
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    114. Poly-ICLC promotes the infiltration of effector T cells into intracranial gliomas via induction of CXCL10 in IFN-alpha and IFN-gamma dependent manners. Cancer Immunol Immunother. 2010 Sep; 59(9):1401-9. Zhu X, Fallert-Junecko BA, Fujita M, Ueda R, Kohanbash G, Kastenhuber ER, McDonald HA, Liu Y, Kalinski P, Reinhart TA, Salazar AM, Okada H. PMID: 20549206; PMCID: PMC2893267.
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    115. Role of type 1 IFNs in antiglioma immunosurveillance--using mouse studies to guide examination of novel prognostic markers in humans. Clin Cancer Res. 2010 Jul 01; 16(13):3409-19. Fujita M, Scheurer ME, Decker SA, McDonald HA, Kohanbash G, Kastenhuber ER, Kato H, Bondy ML, Ohlfest JR, Okada H. PMID: 20472682; PMCID: PMC2896455.
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    116. A candidate H1N1 pandemic influenza vaccine elicits protective immunity in mice. PLoS One. 2010 May 05; 5(5):e10492. Steitz J, Barlow PG, Hossain J, Kim E, Okada K, Kenniston T, Rea S, Donis RO, Gambotto A. PMID: 20463955; PMCID: PMC2864737.
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    117. Polarized dendritic cells as cancer vaccines: directing effector-type T cells to tumors. Semin Immunol. 2010 Jun; 22(3):173-82. Kalinski P, Okada H. PMID: 20409732; PMCID: PMC2892234.
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    118. miR-17-92 expression in differentiated T cells - implications for cancer immunotherapy. J Transl Med. 2010 Feb 18; 8:17. Sasaki K, Kohanbash G, Hoji A, Ueda R, McDonald HA, Reinhart TA, Martinson J, Lotze MT, Marincola FM, Wang E, Fujita M, Okada H. PMID: 20167088; PMCID: PMC2836279.
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    119. MicroRNAs in immune regulation--opportunities for cancer immunotherapy. Int J Biochem Cell Biol. 2010 Aug; 42(8):1256-61. Okada H, Kohanbash G, Lotze MT. PMID: 20144731; PMCID: PMC2889234.
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    120. Balb/c EGFP mice are tolerant against immunization utilizing recombinant adenoviral-based vectors encoding EGFP: a novel model for the study of tolerance mechanisms and vaccine efficacy. Mol Immunol. 2010 Feb; 47(5):1149-53. Steitz J, Soloff AC, Barratt-Boyes SM, Alber SM, Watkins SC, Okada H, Gambotto A. PMID: 20022379.
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    121. Immunotherapy for pediatric central nervous system tumors. Biol Blood Marrow Transplant. 2010 Jan; 16(1 Suppl):S75-81. Gardner SL, Ahmed N, Okada H. PMID: 19896544.
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    122. Systemic inhibition of transforming growth factor-beta in glioma-bearing mice improves the therapeutic efficacy of glioma-associated antigen peptide vaccines. Clin Cancer Res. 2009 Nov 01; 15(21):6551-9. Ueda R, Fujita M, Zhu X, Sasaki K, Kastenhuber ER, Kohanbash G, McDonald HA, Harper J, Lonning S, Okada H. PMID: 19861464; PMCID: PMC2783346.
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    123. IL-4 suppresses very late antigen-4 expression which is required for therapeutic Th1 T-cell trafficking into tumors. J Immunother. 2009 Oct; 32(8):793-802. Sasaki K, Pardee AD, Qu Y, Zhao X, Ueda R, Kohanbash G, Bailey LM, Okada H, Muthuswamy R, Kalinski P, Basse PH, Falo LD, Storkus WJ. PMID: 19752754; PMCID: PMC2796294.
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    124. Brain tumor immunotherapy with type-1 polarizing strategies. Ann N Y Acad Sci. 2009 Sep; 1174:18-23. Okada H. PMID: 19769732.
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    125. Dicer-regulated microRNAs 222 and 339 promote resistance of cancer cells to cytotoxic T-lymphocytes by down-regulation of ICAM-1. Proc Natl Acad Sci U S A. 2009 Jun 30; 106(26):10746-51. Ueda R, Kohanbash G, Sasaki K, Fujita M, Zhu X, Kastenhuber ER, McDonald HA, Potter DM, Hamilton RL, Lotze MT, Khan SA, Sobol RW, Okada H. PMID: 19520829; PMCID: PMC2705554.
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    126. Conditional interleukin-12 gene therapy promotes safe and effective antitumor immunity. Cancer Gene Ther. 2009 Dec; 16(12):883-91. Komita H, Zhao X, Katakam AK, Kumar P, Kawabe M, Okada H, Braughler JM, Storkus WJ. PMID: 19444303; PMCID: PMC3427922.
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    127. Effective immunotherapy against murine gliomas using type 1 polarizing dendritic cells--significant roles of CXCL10. Cancer Res. 2009 Feb 15; 69(4):1587-95. Fujita M, Zhu X, Ueda R, Sasaki K, Kohanbash G, Kastenhuber ER, McDonald HA, Gibson GA, Watkins SC, Muthuswamy R, Kalinski P, Okada H. PMID: 19190335; PMCID: PMC5450639.
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    128. Immunotherapeutic approaches for glioma. Crit Rev Immunol. 2009; 29(1):1-42. Okada H, Kohanbash G, Zhu X, Kastenhuber ER, Hoji A, Ueda R, Fujita M. PMID: 19348609; PMCID: PMC2713019.
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    129. IL-4 inhibits VLA-4 expression on Tc1 cells resulting in poor tumor infiltration and reduced therapy benefit. Eur J Immunol. 2008 Oct; 38(10):2865-73. Sasaki K, Pardee AD, Okada H, Storkus WJ. PMID: 18958887; PMCID: PMC2771926.
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    130. Stat6 signaling suppresses VLA-4 expression by CD8+ T cells and limits their ability to infiltrate tumor lesions in vivo. J Immunol. 2008 Jul 01; 181(1):104-8. Sasaki K, Zhao X, Pardee AD, Ueda R, Fujita M, Sehra S, Kaplan MH, Kane LP, Okada H, Storkus WJ. PMID: 18566374; PMCID: PMC2596982.
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    131. Expression of glioma-associated antigens in pediatric brain stem and non-brain stem gliomas. J Neurooncol. 2008 Jul; 88(3):245-50. Okada H, Low KL, Kohanbash G, McDonald HA, Hamilton RL, Pollack IF. PMID: 18324354; PMCID: PMC2561297.
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    132. Inhibition of STAT3 promotes the efficacy of adoptive transfer therapy using type-1 CTLs by modulation of the immunological microenvironment in a murine intracranial glioma. J Immunol. 2008 Feb 15; 180(4):2089-98. Fujita M, Zhu X, Sasaki K, Ueda R, Low KL, Pollack IF, Okada H. PMID: 18250414.
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    133. Spontaneous immune responses against glioma-associated antigens in a long term survivor with malignant glioma. J Transl Med. 2007 Dec 19; 5:68. Ueda R, Low KL, Zhu X, Fujita M, Sasaki K, Whiteside TL, Butterfield LH, Okada H. PMID: 18093336; PMCID: PMC2244605.
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    134. Autologous glioma cell vaccine admixed with interleukin-4 gene transfected fibroblasts in the treatment of patients with malignant gliomas. J Transl Med. 2007 Dec 19; 5:67. Okada H, Lieberman FS, Walter KA, Lunsford LD, Kondziolka DS, Bejjani GK, Hamilton RL, Torres-Trejo A, Kalinski P, Cai Q, Mabold JL, Edington HD, Butterfield LH, Whiteside TL, Potter DM, Schold SC, Pollack IF. PMID: 18093335; PMCID: PMC2254376.
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    135. Helper function of memory CD8+ T cells: heterologous CD8+ T cells support the induction of therapeutic cancer immunity. Cancer Res. 2007 Oct 15; 67(20):10012-8. Nakamura Y, Watchmaker P, Urban J, Sheridan B, Giermasz A, Nishimura F, Sasaki K, Cumberland R, Muthuswamy R, Mailliard RB, Larregina AT, Falo LD, Gooding W, Storkus WJ, Okada H, Hendricks RL, Kalinski P. PMID: 17942935; PMCID: PMC2905256.
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    136. Preferential expression of very late antigen-4 on type 1 CTL cells plays a critical role in trafficking into central nervous system tumors. Cancer Res. 2007 Jul 01; 67(13):6451-8. Sasaki K, Zhu X, Vasquez C, Nishimura F, Dusak JE, Huang J, Fujita M, Wesa A, Potter DM, Walker PR, Storkus WJ, Okada H. PMID: 17616706.
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    137. Treatment-enhanced CD4+Foxp3+ glucocorticoid-induced TNF receptor family related high regulatory tumor-infiltrating T cells limit the effectiveness of cytokine-based immunotherapy. J Immunol. 2007 Mar 15; 178(6):3400-8. Berhanu A, Huang J, Watkins SC, Okada H, Storkus WJ. PMID: 17339434.
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    138. Toll like receptor-3 ligand poly-ICLC promotes the efficacy of peripheral vaccinations with tumor antigen-derived peptide epitopes in murine CNS tumor models. J Transl Med. 2007 Feb 12; 5:10. Zhu X, Nishimura F, Sasaki K, Fujita M, Dusak JE, Eguchi J, Fellows-Mayle W, Storkus WJ, Walker PR, Salazar AM, Okada H. PMID: 17295916; PMCID: PMC1802742.
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    139. Antigenic profiling of glioma cells to generate allogeneic vaccines or dendritic cell-based therapeutics. Clin Cancer Res. 2007 Jan 15; 13(2 Pt 1):566-575. Zhang JG, Eguchi J, Kruse CA, Gomez GG, Fakhrai H, Schroter S, Ma W, Hoa N, Minev B, Delgado C, Wepsic HT, Okada H, Jadus MR. PMID: 17255279; PMCID: PMC4030524.
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    140. Progression-associated genes in astrocytoma identified by novel microarray gene expression data reanalysis. Methods Mol Biol. 2007; 377:203-22. MacDonald TJ, Pollack IF, Okada H, Bhattacharya S, Lyons-Weiler J. PMID: 17634619.
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    141. Identification of interleukin-13 receptor alpha2 peptide analogues capable of inducing improved antiglioma CTL responses. Cancer Res. 2006 Jun 01; 66(11):5883-91. Eguchi J, Hatano M, Nishimura F, Zhu X, Dusak JE, Sato H, Pollack IF, Storkus WJ, Okada H. PMID: 16740728.
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    142. Adoptive transfer of type 1 CTL mediates effective anti-central nervous system tumor response: critical roles of IFN-inducible protein-10. Cancer Res. 2006 Apr 15; 66(8):4478-87. Nishimura F, Dusak JE, Eguchi J, Zhu X, Gambotto A, Storkus WJ, Okada H. PMID: 16618775.
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    143. Epidermal growth factor receptor-transfected bone marrow stromal cells exhibit enhanced migratory response and therapeutic potential against murine brain tumors. Cancer Gene Ther. 2005 Sep; 12(9):757-68. Sato H, Kuwashima N, Sakaida T, Hatano M, Dusak JE, Fellows-Mayle WK, Papworth GD, Watkins SC, Gambotto A, Pollack IF, Okada H. PMID: 15832173.
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    144. Delivery of dendritic cells engineered to secrete IFN-alpha into central nervous system tumors enhances the efficacy of peripheral tumor cell vaccines: dependence on apoptotic pathways. J Immunol. 2005 Aug 15; 175(4):2730-40. Kuwashima N, Nishimura F, Eguchi J, Sato H, Hatano M, Tsugawa T, Sakaida T, Dusak JE, Fellows-Mayle WK, Papworth GD, Watkins SC, Gambotto A, Pollack IF, Storkus WJ, Okada H. PMID: 16081851.
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    145. EphA2 as a glioma-associated antigen: a novel target for glioma vaccines. Neoplasia. 2005 Aug; 7(8):717-22. Hatano M, Eguchi J, Tatsumi T, Kuwashima N, Dusak JE, Kinch MS, Pollack IF, Hamilton RL, Storkus WJ, Okada H. PMID: 16207473; PMCID: PMC1501889.
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    146. IL-4-transfected tumor cell vaccines activate tumor-infiltrating dendritic cells and promote type-1 immunity. J Immunol. 2005 Jun 01; 174(11):7194-201. Eguchi J, Kuwashima N, Hatano M, Nishimura F, Dusak JE, Storkus WJ, Okada H. PMID: 15905564.
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    147. [Immunotherapy for brain tumor: don't get "Lost in Translation"]. No Shinkei Geka. 2005 May; 33(5):433-42. Okada H. PMID: 15912763.
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    148. The characterization of tumor apoptosis after experimental radiosurgery. Stereotact Funct Neurosurg. 2005; 83(1):17-24. Witham TF, Okada H, Fellows W, Hamilton RL, Flickinger JC, Chambers WH, Pollack IF, Watkins SC, Kondziolka D. PMID: 15775705.
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    149. Vaccination with EphA2-derived T cell-epitopes promotes immunity against both EphA2-expressing and EphA2-negative tumors. J Transl Med. 2004 Nov 24; 2(1):40. Hatano M, Kuwashima N, Tatsumi T, Dusak JE, Nishimura F, Reilly KM, Storkus WJ, Okada H. PMID: 15563374; PMCID: PMC535538.
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    150. Sequential delivery of interferon-alpha gene and DCs to intracranial gliomas promotes an effective antitumor response. Gene Ther. 2004 Nov; 11(21):1551-8. Tsugawa T, Kuwashima N, Sato H, Fellows-Mayle WK, Dusak JE, Okada K, Papworth GD, Watkins SC, Gambotto A, Yoshida J, Pollack IF, Okada H. PMID: 15343358.
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    151. Cytokine gene therapy for malignant glioma. Expert Opin Biol Ther. 2004 Oct; 4(10):1609-20. Okada H, Pollack IF. PMID: 15461572.
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    152. Delivery of interferon-alpha transfected dendritic cells into central nervous system tumors enhances the antitumor efficacy of peripheral peptide-based vaccines. Cancer Res. 2004 Aug 15; 64(16):5830-8. Okada H, Tsugawa T, Sato H, Kuwashima N, Gambotto A, Okada K, Dusak JE, Fellows-Mayle WK, Papworth GD, Watkins SC, Chambers WH, Potter DM, Storkus WJ, Pollack IF. PMID: 15313927.
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    153. Biologic therapy for brain cancers--based on cellular and immunobiology. Yonsei Med J. 2004 Jun 30; 45 Suppl:68-70. Okada H. PMID: 15250054.
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    154. Intratumoral delivery of dendritic cells engineered to secrete both interleukin (IL)-12 and IL-18 effectively treats local and distant disease in association with broadly reactive Tc1-type immunity. Cancer Res. 2003 Oct 01; 63(19):6378-86. Tatsumi T, Huang J, Gooding WE, Gambotto A, Robbins PD, Vujanovic NL, Alber SM, Watkins SC, Okada H, Storkus WJ. PMID: 14559827.
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    155. Autologous glioma cell vaccine admixed with interleukin-4 gene transfected fibroblasts in the treatment of recurrent glioblastoma: preliminary observations in a patient with a favorable response to therapy. J Neurooncol. 2003 Aug-Sep; 64(1-2):13-20. Okada H, Lieberman FS, Edington HD, Witham TF, Wargo MJ, Cai Q, Elder EH, Whiteside TL, Schold SC, Pollack IF. PMID: 12952282.
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    156. Expression of a soluble transforming growth factor-beta (TGFbeta) receptor reduces tumorigenicity by regulating natural killer (NK) cell activity against 9L gliosarcoma in vivo. J Neurooncol. 2003 Aug-Sep; 64(1-2):63-9. Witham TF, Villa L, Yang T, Pollack IF, Okada H, Robbins PD, Chambers WH. PMID: 12952287.
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    157. Effective induction of antiglioma cytotoxic T cells by coadministration of interferon-beta gene vector and dendritic cells. Cancer Gene Ther. 2003 Jul; 10(7):549-58. Nakahara N, Pollack IF, Storkus WJ, Wakabayashi T, Yoshida J, Okada H. PMID: 12833135.
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    158. Gene therapy and biologic therapy with interleukin-4. Curr Gene Ther. 2002 Dec; 2(4):437-50. Okada H, Kuwashima N. PMID: 12477255.
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    159. Identification of a novel HLA-A*0201-restricted, cytotoxic T lymphocyte epitope in a human glioma-associated antigen, interleukin 13 receptor alpha2 chain. Clin Cancer Res. 2002 Sep; 8(9):2851-5. Okano F, Storkus WJ, Chambers WH, Pollack IF, Okada H. PMID: 12231526.
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    160. 7-Hydroxystaurosporine-induced apoptosis in 9L glioma cells provides an effective antigen source for dendritic cells and yields a potent vaccine strategy in an intracranial glioma model. Neurosurgery. 2002 Jun; 50(6):1327-34; discussion 1334-5. Witham TF, Erff ML, Okada H, Chambers WH, Pollack IF. PMID: 12015852.
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    161. Glioma-associated hyaluronan induces apoptosis in dendritic cells via inducible nitric oxide synthase: implications for the use of dendritic cells for therapy of gliomas. Cancer Res. 2002 May 01; 62(9):2583-91. Yang T, Witham TF, Villa L, Erff M, Attanucci J, Watkins S, Kondziolka D, Okada H, Pollack IF, Chambers WH. PMID: 11980653.
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    162. Combination of stereotactic radiosurgery and cytokine gene-transduced tumor cell vaccination: a new strategy against metastatic brain tumors. J Neurosurg. 2001 Dec; 95(6):984-9. Nakahara N, Okada H, Witham TF, Attanucci J, Fellows WK, Chambers WH, Niranjan A, Kondziolka D, Pollack IF. PMID: 11765844.
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    163. Cytokine gene therapy of gliomas: effective induction of therapeutic immunity to intracranial tumors by peripheral immunization with interleukin-4 transduced glioma cells. Gene Ther. 2001 Aug; 8(15):1157-66. Okada H, Villa L, Attanucci J, Erff M, Fellows WK, Lotze MT, Pollack IF, Chambers WH. PMID: 11509946.
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    164. Gene therapy of malignant gliomas: a pilot study of vaccination with irradiated autologous glioma and dendritic cells admixed with IL-4 transduced fibroblasts to elicit an immune response. Hum Gene Ther. 2001 Mar 20; 12(5):575-95. Okada H, Pollack IF, Lieberman F, Lunsford LD, Kondziolka D, Schiff D, Attanucci J, Edington H, Chambers W, Kalinski P, Kinzler D, Whiteside T, Elder E, Potter D. PMID: 11268289.
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    165. Immunization with an antigen identified by cytokine tumor vaccine-assisted SEREX (CAS) suppressed growth of the rat 9L glioma in vivo. Cancer Res. 2001 Mar 15; 61(6):2625-31. Okada H, Attanucci J, Giezeman-Smits KM, Brissette-Storkus C, Fellows WK, Gambotto A, Pollack LF, Pogue-Geile K, Lotze MT, Bozik ME, Chambers WH. PMID: 11289140.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    166. Exploitation of immune mechanisms in the treatment of central nervous system cancer. Semin Pediatr Neurol. 2000 Jun; 7(2):131-43. Pollack IF, Okada H, Chambers WH. PMID: 10914414.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    167. Cytokine gene therapy of gliomas: induction of reactive CD4+ T cells by interleukin-4-transfected 9L gliosarcoma is essential for protective immunity. Cancer Res. 2000 May 01; 60(9):2449-57. Giezeman-Smits KM, Okada H, Brissette-Storkus CS, Villa LA, Attanucci J, Lotze MT, Pollack IF, Bozik ME, Chambers WH. PMID: 10811123.
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    168. Characterization and transduction of a retroviral vector encoding human interleukin-4 and herpes simplex virus-thymidine kinase for glioma tumor vaccine therapy. Cancer Gene Ther. 2000 Mar; 7(3):486-94. Okada H, Attanucci J, Tahara H, Pollack IF, Bozik ME, Chambers WH, Lotze MT. PMID: 10766355.
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    169. Gene therapy of malignant gliomas: a phase I study of IL-4-HSV-TK gene-modified autologous tumor to elicit an immune response. Hum Gene Ther. 2000 Mar 01; 11(4):637-53. Okada H, Pollack IF, Lotze MT, Lunsford LD, Kondziolka D, Lieberman F, Schiff D, Attanucci J, Edington H, Chambers W, Robbins P, Baar J, Kinzler D, Whiteside T, Elder E. PMID: 10724042.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCellsCTClinical Trials
    170. Interleukin-2: developing additional cytokine gene therapies using fibroblasts or dendritic cells to enhance tumor immunity. Cancer J Sci Am. 2000 Feb; 6 Suppl 1:S61-6. Lotze MT, Shurin M, Esche C, Tahara H, Storkus W, Kirkwood JM, Whiteside TL, Elder EM, Okada H, Robbins P. PMID: 10685662.
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    171. Effective cytokine gene therapy against an intracranial glioma using a retrovirally transduced IL-4 plus HSVtk tumor vaccine. Gene Ther. 1999 Feb; 6(2):219-26. Okada H, Giezeman-Smits KM, Tahara H, Attanucci J, Fellows WK, Lotze MT, Chambers WH, Bozik ME. PMID: 10435106.
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    172. [Neurosurgery and molecular biology: (series 10) gene therapy and biological therapy for brain tumors]. No Shinkei Geka. 1999 Jan; 27(1):9-17. Okada H. PMID: 10024979.
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    173. Bone marrow-derived dendritic cells pulsed with a tumor-specific peptide elicit effective anti-tumor immunity against intracranial neoplasms. Int J Cancer. 1998 Oct 05; 78(2):196-201. Okada H, Tahara H, Shurin MR, Attanucci J, Giezeman-Smits KM, Fellows WK, Lotze MT, Chambers WH, Bozik ME. PMID: 9754652.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
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