Holly Ingraham, PhD

Title(s)Professor, Cellular Molecular Pharmacology
SchoolSchool of Medicine
Address1550 Fourth St, #284F
San Francisco CA 94158
Phone415-476-3401
Emailholly.ingraham@ucsf.edu
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    Collapse Biography 
    Collapse Awards and Honors
    2002Brook Byers Basic Science Award
    2012Elected Fellow of American Association for Advancement of Science (AAAS)
    2006Herzstein Distinguished Investigator in Molecular Physiology
    2017Chancellor’s Award Martin Luther King, Jr. (MLK) Leadership
    2018Joseph Larner Memorial Lectureship Award in Pharmacology
    2019Elected American Academy of Arts and Science (AAA&S)
    201942nd Annual Steenbock Lectureship Award in Biochemistry
    2020Hertzstein Endowed Professorship In Molecular Physiology
    2020GCRLE Senior Scholar
    2021Elected National Academy of Sciences (NAS)
    2022John and Margaret Faulkner Lectureship, University of Michigan, MI
    2023Edwin B. Astwood Award for Outstanding Research in Basic Science, Endo Society

    Collapse Overview 
    Collapse Overview
    About our Reserch: Please visit my website at https://ingrahamlab.ucsf.edu on our current research efforts on the basic science of "Hormones and Nerves in Female Physiology" aimed at improving women's health.

    About Me: Those who devote their lives to creative pursuits are often inspired by a singular event. Mine came from my great-grandfather, whose 1890 Bausch & Lomb microscope, abandoned in a closet after being shipped west from Worcester Massachusetts, came into my possession when I was 10 years old. I picked it up and began exploring the biological world of Northern California, never to stop. But sporadic events are not enough to support a lifetime of curiosity and discovery. That support would come via the State of California through an amazing and accessible public education system beginning at Revelle College at UCSD, and through the NIH, which has supported my curiosity-based discovery research program continuoulsy for over 25 years. Unwavering support also comes from my family and mentors who provide the personal strength and resiliency needed to overcome moments of disappointment, insecurity, and self-doubt. I thoroughly enjoy my life as a scientist and continue to be addicted to the rare experimental successes sprinkled among the many failures inherent in the scientific process.

    About Diversity: In partnership with San Francisco State University, I also direct the UCSF IRACDA Scholars Program to build diversity in our nation's biomedical workforce and faculty. Our efforts along with generous funding from an NIGMS K12 grant and the UCSF School of Medicine provide career development programming for a cohort of postdoctoral fellows. With Ms. Anne Sufka, we recently launched Path-To-Postdoc@UCSF Program, a funded opportunity for prospective fellows to interact with UCSF's vibrant research community. Our local efforts today will make a national difference tomorrow.

    Collapse Research 
    Collapse Research Activities and Funding
    Novel Drivers in Central Control of Female Reproduction
    GCRLE AwardSep 1, 2020 - Aug 30, 2022
    Role: Principal Investigator
    Dissecting a hormone-responsive processor for female activity and repetitive behavior
    NIH R01DK121657Mar 1, 2020 - Feb 28, 2025
    Role: Principal Investigator
    Arcuate ERa Signaling in Central Control of Female Bone Metabolism
    NIH/NIA R01 AG062331-01A1Oct 1, 2019 - Sep 30, 2024
    Role: Pincipal Investigator
    Mapping gut-spinal cord connections in visceral pain
    NIH/NINDS U01 NS113869Oct 1, 2019 - Sep 30, 2022
    Role: Co-Principal Investigator
    Arcuate ERa Signaling in Central Control of Female Bone Metabolism
    NIH R01AG062331Sep 30, 2019 - May 31, 2024
    Role: Principal Investigator
    UCSF Nutrition Obesity Research Center
    NIH P30DK098722Aug 1, 2015 - Jul 31, 2025
    Role: Co-Investigator
    Mapping Hypothalamic Neurocircuits Controlling Physical Activity
    NIH R01DK099722Apr 1, 2014 - Mar 31, 2019
    Role: Principal Investigator
    Molecular Mechanisms of Atrazine in Altering the Endocrine Gene Network
    NIH R21ES017136Jul 1, 2009 - Jun 30, 2011
    Role: Principal Investigator
    UCSF IRACDA Scholars Program
    NIH K12GM081266Aug 3, 2007 - Jul 31, 2022
    Role: Principal Investigator
    Structural Analyses of NR5 Orphan Nuclear Receptors
    NIH R01DK072246Jul 15, 2005 - May 31, 2012
    Role: Principal Investigator
    Modulating Nuclear Receptor Activity via Sumoylation
    NIH R01DK070024Sep 30, 2004 - Jul 31, 2013
    Role: Principal Investigator
    STRUCTURE AND DYNAMICS OF NUCLEAR RECEPTORS
    NIH P01DK058390Aug 15, 2000 - Jul 31, 2006
    Role: Co-Investigator
    30TH GORDON CONFERENCE ON HORMONE ACTION
    NIH R13DK056229Jul 15, 1999 - Jun 30, 2000
    Role: Principal Investigator
    CELLULAR SIGNALING IN REPRODUCTIVE TRACT DEVELOPMENT
    NIH R01HD036233Apr 15, 1998 - Mar 31, 2004
    Role: Principal Investigator
    GENE EXPRESSION IN MAMMALIAN REPRODUCTIVE DEVELOPMENT
    NIH K02HD001178Jul 1, 1997 - Jun 30, 2002
    Role: Principal Investigator
    Developmental Programs of Neural Circuits in the Mouse Medial Hypothalamus
    NIH R01DK063592Aug 1, 1993 - Mar 31, 2014
    Role: Principal Investigator
    GENE REGULATION IN MAMMALIAN SEX DETERMINATION
    NIH R01HD030725Aug 1, 1993 - Jul 31, 2002
    Role: Principal Investigator
    MOLECULAR ANALYSIS OF PITUITARY DEVELOPMENT
    NIH R01DK046048Jul 1, 1993 - Jun 30, 1997
    Role: Principal Investigator

    Collapse Featured Content 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Brain-Derived CCN3 Is An Osteoanabolic Hormone That Sustains Bone in Lactating Females. bioRxiv. 2023 Nov 16. Babey ME, Krause WC, Herber CB, Chen K, Nikkanen J, Rodriquez R, Zhang X, Castro-Navarro F, Wang Y, Villeda S, Lane NE, Scheller EL, Chan CKF, Ambrosi TH, Ingraham HA. PMID: 37693376; PMCID: PMC10491109.
      View in: PubMed   Mentions:
    2. Holly Ingraham. Neuron. 2023 11 01; 111(21):3347-3350. Ingraham HA. PMID: 37918349.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    3. Gut enterochromaffin cells drive visceral pain and anxiety. Nature. 2023 04; 616(7955):137-142. Bayrer JR, Castro J, Venkataraman A, Touhara KK, Rossen ND, Morrie RD, Maddern J, Hendry A, Braverman KN, Garcia-Caraballo S, Schober G, Brizuela M, Castro Navarro FM, Bueno-Silva C, Ingraham HA, Brierley SM, Julius D. PMID: 36949192; PMCID: PMC10827380.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    4. RF18 | PSAT143 Brain Determinants of Dynamic Bone Remodeling in Females. Journal of the Endocrine Society. 2022 Nov 1; 6(Suppl 1):a226-a227. Babey BM, Krause KW, Zhang ZX, Argiris AJ, Nikkanen NJ, Herber HC, Scheller SE, Ingraham IH. .
      View in: Publisher Site   Mentions:
    5. An evolutionary trade-off between host immunity and metabolism drives fatty liver in male mice. Science. 2022 10 21; 378(6617):290-295. Nikkanen J, Leong YA, Krause WC, Dermadi D, Maschek JA, Van Ry T, Cox JE, Weiss EJ, Gokcumen O, Chawla A, Ingraham HA. PMID: 36264814; PMCID: PMC9870047.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    6. Running the Female Power Grid Across Lifespan Through Brain Estrogen Signaling. Annu Rev Physiol. 2022 02 10; 84:59-85. Ingraham HA, Herber CB, Krause WC. PMID: 34780257; PMCID: PMC8831472.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    7. Oestrogen engages brain MC4R signalling to drive physical activity in female mice. Nature. 2021 11; 599(7883):131-135. Krause WC, Rodriguez R, Gegenhuber B, Matharu N, Rodriguez AN, Padilla-Roger AM, Toma K, Herber CB, Correa SM, Duan X, Ahituv N, Tollkuhn J, Ingraham HA. PMID: 34646010; PMCID: PMC9113400.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    8. Chronic Stimulation of Arcuate Kiss1 Neurons Decreases Bone Mass in Female Mice. Journal of the Endocrine Society. 2021 May 3; 5(Suppl 1):a232-a232. Rodriguez RR, Herber HC, Krause KW, Ingraham IH. .
      View in: Publisher Site   Mentions:
    9. SPARC - Mapping Gut-Spinal Cord Connections in Visceral Pain. The FASEB Journal. 2020 Apr 1; 34(S1):1-1. Morrie MR, Bayrer BJ, Brierley BS, Ingraham IH, Julius JD. .
      View in: Publisher Site   Mentions:
    10. Should We Make More Bone or Not, As Told by Kisspeptin Neurons in the Arcuate Nucleus. Semin Reprod Med. 2019 05; 37(3):147-150. Herber CB, Ingraham HA. PMID: 31869843; PMCID: PMC7233264.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    11. Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones. . 2019 Sep 12. CB CH, WC WK, L LW, JR JB, A AL, M MS, A AF, B BF, Z ZZ, MS MR, DK DN, RA RN, SM SC, HA HI. .
      View in: Publisher Site   Mentions:
    12. 948 – Nuclear Receptor Liver Receptor Homolog-1 Promotes Intestinal Notch Signaling and Enteroendocrine Cell Development. Gastroenterology. 2019 May 1; 156(6):s-202. Choksi CP, Ingraham IH, Bayrer BJ. .
      View in: Publisher Site   Mentions:
    13. Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones. Nat Commun. 2019 01 11; 10(1):163. Herber CB, Krause WC, Wang L, Bayrer JR, Li A, Schmitz M, Fields A, Ford B, Zhang Z, Reid MS, Nomura DK, Nissenson RA, Correa SM, Ingraham HA. PMID: 30635563; PMCID: PMC6329772.
      View in: PubMed   Mentions: 35     Fields:    Translation:Animals
    14. LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival. Nat Commun. 2018 10 10; 9(1):4055. Bayrer JR, Wang H, Nattiv R, Suzawa M, Escusa HS, Fletterick RJ, Klein OD, Moore DD, Ingraham HA. PMID: 30305617; PMCID: PMC6180039.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimals
    15. 273 - Nuclear Receptor LRH-1 Mitigates Intestinal Inflammatory Disease by Promoting Stem Cell Survival and Directing Normal Epithelial Composition. Gastroenterology. 2018 May 1; 154(6):s-67. Bayrer BJ, Escusa EH, Kein KO, Ingraham IH. .
      View in: Publisher Site   Mentions:
    16. LRH-1 regulates hepatic lipid homeostasis and maintains arachidonoyl phospholipid pools critical for phospholipid diversity. JCI Insight. 2018 03 08; 3(5). Miranda DA, Krause WC, Cazenave-Gassiot A, Suzawa M, Escusa H, Foo JC, Shihadih DS, Stahl A, Fitch M, Nyangau E, Hellerstein M, Wenk MR, Silver DL, Ingraham HA. PMID: 29515023; PMCID: PMC5922282.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    17. Timing of adrenal regression controlled by synergistic interaction between Sf1 SUMOylation and Dax1. Development. 2017 10 15; 144(20):3798-3807. Xing Y, Morohashi KI, Ingraham HA, Hammer GD. PMID: 28893949; PMCID: PMC5675444.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    18. Abstract 281: Hepatic Liver Receptor Homolog-1, a Key Regulator of Lipid Storage and Phospholipid Diversity. Circulation Research. 2017 Jul 21; 121(suppl_1). Miranda MD, Krause KW, Cazenave CA, Escusa EH, Shihadih SD, Stahl SA, Wenk WM, Silver SD, Ingraham IH. .
      View in: Publisher Site   Mentions:
    19. Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways. Cell. 2017 Jun 29; 170(1):185-198.e16. Bellono NW, Bayrer JR, Leitch DB, Castro J, Zhang C, O'Donnell TA, Brierley SM, Ingraham HA, Julius D. PMID: 28648659; PMCID: PMC5839326.
      View in: PubMed   Mentions: 313     Fields:    Translation:HumansAnimalsCells
    20. Origins and Functions of the Ventrolateral VMH: A Complex Neuronal Cluster Orchestrating Sex Differences in Metabolism and Behavior. Adv Exp Med Biol. 2017; 1043:199-213. Krause WC, Ingraham HA. PMID: 29224096; PMCID: PMC5839321.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    21. Testosterone Rapidly Augments Retrograde Endocannabinoid Signaling in Proopiomelanocortin Neurons to Suppress Glutamatergic Input from Steroidogenic Factor 1 Neurons via Upregulation of Diacylglycerol Lipase-α. Neuroendocrinology. 2017; 105(4):341-356. Conde K, Fabelo C, Krause WC, Propst R, Goethel J, Fischer D, Hur J, Meza C, Ingraham HA, Wagner EJ. PMID: 27871072; PMCID: PMC5839320.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    22. Disulfide-Trapping Identifies a New, Effective Chemical Probe for Activating the Nuclear Receptor Human LRH-1 (NR5A2). PLoS One. 2016; 11(7):e0159316. de Jesus Cortez F, Suzawa M, Irvy S, Bruning JM, Sablin E, Jacobson MP, Fletterick RJ, Ingraham HA, England PM. PMID: 27467220; PMCID: PMC4965143.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    23. A gene-expression screen identifies a non-toxic sumoylation inhibitor that mimics SUMO-less human LRH-1 in liver. Elife. 2015 Dec 11; 4. Suzawa M, Miranda DA, Ramos KA, Ang KK, Faivre EJ, Wilson CG, Caboni L, Arkin MR, Kim YS, Fletterick RJ, Diaz A, Schneekloth JS, Ingraham HA. PMID: 26653140; PMCID: PMC4749390.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    24. Structure of Liver Receptor Homolog-1 (NR5A2) with PIP3 hormone bound in the ligand binding pocket. J Struct Biol. 2015 Dec; 192(3):342-348. Sablin EP, Blind RD, Uthayaruban R, Chiu HJ, Deacon AM, Das D, Ingraham HA, Fletterick RJ. PMID: 26416531; PMCID: PMC4651778.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    25. Sex-dependent changes in metabolism and behavior, as well as reduced anxiety after eliminating ventromedial hypothalamus excitatory output. Mol Metab. 2015 Nov; 4(11):857-66. Cheung CC, Krause WC, Edwards RH, Yang CF, Shah NM, Hnasko TS, Ingraham HA. PMID: 26629409; PMCID: PMC4632173.
      View in: PubMed   Mentions: 25     Fields:    
    26. The Signaling Phospholipid PIP3 Functions As a Ligand Hormone For Nuclear Receptors. The FASEB Journal. 2015 Apr 1; 29. Ingraham IH, Blind BR, Sablin SE, Das DD, Fletterick FR. .
      View in: Publisher Site   Mentions:
    27. An estrogen-responsive module in the ventromedial hypothalamus selectively drives sex-specific activity in females. Cell Rep. 2015 Jan 06; 10(1):62-74. Correa SM, Newstrom DW, Warne JP, Flandin P, Cheung CC, Lin-Moore AT, Pierce AA, Xu AW, Rubenstein JL, Ingraham HA. PMID: 25543145; PMCID: PMC4324838.
      View in: PubMed   Mentions: 81     Fields:    Translation:AnimalsCells
    28. The signaling phospholipid PIP3 creates a new interaction surface on the nuclear receptor SF-1. Proc Natl Acad Sci U S A. 2014 Oct 21; 111(42):15054-9. Blind RD, Sablin EP, Kuchenbecker KM, Chiu HJ, Deacon AM, Das D, Fletterick RJ, Ingraham HA. PMID: 25288771; PMCID: PMC4210282.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    29. Genetic labeling of steroidogenic factor-1 (SF-1) neurons in mice reveals ventromedial nucleus of the hypothalamus (VMH) circuitry beginning at neurogenesis and development of a separate non-SF-1 neuronal cluster in the ventrolateral VMH. J Comp Neurol. 2013 Apr 15; 521(6):1268-88. Cheung CC, Kurrasch DM, Liang JK, Ingraham HA. PMID: 22987798; PMCID: PMC4304766.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    30. Science Signaling Podcast: 19 June 2012. Science Signaling. 2012 Jun 19; 5(229):pc13-pc13. Ingraham IH, Blind BR, VanHook VA. .
      View in: Publisher Site   Mentions:
    31. Direct modification and activation of a nuclear receptor-PIP₂ complex by the inositol lipid kinase IPMK. Sci Signal. 2012 Jun 19; 5(229):ra44. Blind RD, Suzawa M, Ingraham HA. PMID: 22715467; PMCID: PMC3395721.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    32. An affective disorder in zebrafish with mutation of the glucocorticoid receptor. Mol Psychiatry. 2013 Jun; 18(6):681-91. Ziv L, Muto A, Schoonheim PJ, Meijsing SH, Strasser D, Ingraham HA, Schaaf MJ, Yamamoto KR, Baier H. PMID: 22641177; PMCID: PMC4065652.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimalsCells
    33. Eliminating SF-1 (NR5A1) sumoylation in vivo results in ectopic hedgehog signaling and disruption of endocrine development. Dev Cell. 2011 Aug 16; 21(2):315-27. Lee FY, Faivre EJ, Suzawa M, Lontok E, Ebert D, Cai F, Belsham DD, Ingraham HA. PMID: 21820362; PMCID: PMC3157481.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    34. Metabolism: A lipid for fat disorders. Nature. 2011 Jun 22; 474(7352):455-6. Ingraham HA. PMID: 21697939.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    35. Demasculinization and feminization of male gonads by atrazine: consistent effects across vertebrate classes. J Steroid Biochem Mol Biol. 2011 Oct; 127(1-2):64-73. Hayes TB, Anderson LL, Beasley VR, de Solla SR, Iguchi T, Ingraham H, Kestemont P, Kniewald J, Kniewald Z, Langlois VS, Luque EH, McCoy KA, Muñoz-de-Toro M, Oka T, Oliveira CA, Orton F, Ruby S, Suzawa M, Tavera-Mendoza LE, Trudeau VL, Victor-Costa AB, Willingham E. PMID: 21419222; PMCID: PMC4303243.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimals
    36. Small molecule agonists of the orphan nuclear receptors steroidogenic factor-1 (SF-1, NR5A1) and liver receptor homologue-1 (LRH-1, NR5A2). J Med Chem. 2011 Apr 14; 54(7):2266-81. Whitby RJ, Stec J, Blind RD, Dixon S, Leesnitzer LM, Orband-Miller LA, Williams SP, Willson TM, Xu R, Zuercher WJ, Cai F, Ingraham HA. PMID: 21391689; PMCID: PMC4151520.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    37. Hypothalamic Fetal Programming of Energy Homeostasis. Obesity Before Birth. 2011 Jan 1; 30:301-319. Cheung CC, Ingraham IH. .
      View in: Publisher Site   Mentions:
    38. Molecular pathways controlling development of thalamus and hypothalamus: from neural specification to circuit formation. J Neurosci. 2010 Nov 10; 30(45):14925-30. Blackshaw S, Scholpp S, Placzek M, Ingraham H, Simerly R, Shimogori T. PMID: 21068293; PMCID: PMC6633850.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    39. Regulation of C. elegans fat uptake and storage by acyl-CoA synthase-3 is dependent on NR5A family nuclear hormone receptor nhr-25. Cell Metab. 2010 Oct 06; 12(4):398-410. Mullaney BC, Blind RD, Lemieux GA, Perez CL, Elle IC, Faergeman NJ, Van Gilst MR, Ingraham HA, Ashrafi K. PMID: 20889131; PMCID: PMC2992884.
      View in: PubMed   Mentions: 37     Fields:    Translation:Animals
    40. Stimulating the GPR30 estrogen receptor with a novel tamoxifen analogue activates SF-1 and promotes endometrial cell proliferation. Cancer Res. 2009 Jul 01; 69(13):5415-23. Lin BC, Suzawa M, Blind RD, Tobias SC, Bulun SE, Scanlan TS, Ingraham HA. PMID: 19549922; PMCID: PMC2756996.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    41. Neuroendocrine transcriptional programs adapt dynamically to the supply and demand for neuropeptides as revealed in NSF mutant zebrafish. Neural Dev. 2009 Jun 23; 4:22. Kurrasch DM, Nevin LM, Wong JS, Baier H, Ingraham HA. PMID: 19549326; PMCID: PMC2715394.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    42. The structure of corepressor Dax-1 bound to its target nuclear receptor LRH-1. Proc Natl Acad Sci U S A. 2008 Nov 25; 105(47):18390-5. Sablin EP, Woods A, Krylova IN, Hwang P, Ingraham HA, Fletterick RJ. PMID: 19015525; PMCID: PMC2587556.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    43. Structure of SF-1 bound by different phospholipids: evidence for regulatory ligands. Mol Endocrinol. 2009 Jan; 23(1):25-34. Sablin EP, Blind RD, Krylova IN, Ingraham JG, Cai F, Williams JD, Fletterick RJ, Ingraham HA. PMID: 18988706; PMCID: PMC2646595.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    44. Decreased recognition of SUMO-sensitive target genes following modification of SF-1 (NR5A1). Mol Cell Biol. 2008 Dec; 28(24):7476-86. Campbell LA, Faivre EJ, Show MD, Ingraham JG, Flinders J, Gross JD, Ingraham HA. PMID: 18838537; PMCID: PMC2593425.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    45. Nuclear Receptors, Chemistry of. Wiley Encyclopedia of Chemical Biology. 2008 May 15; 1-10. Campbell CL, Ingraham IH. .
      View in: Publisher Site   Mentions:
    46. The herbicide atrazine activates endocrine gene networks via non-steroidal NR5A nuclear receptors in fish and mammalian cells. PLoS One. 2008 May 07; 3(5):e2117. Suzawa M, Ingraham HA. PMID: 18461179; PMCID: PMC2362696.
      View in: PubMed   Mentions: 37     Fields:    Translation:Animals
    47. The neonatal ventromedial hypothalamus transcriptome reveals novel markers with spatially distinct patterning. J Neurosci. 2007 Dec 12; 27(50):13624-34. Kurrasch DM, Cheung CC, Lee FY, Tran PV, Hata K, Ingraham HA. PMID: 18077674; PMCID: PMC6673626.
      View in: PubMed   Mentions: 88     Fields:    Translation:AnimalsCells
    48. International Union of Pharmacology. LXVI. Orphan nuclear receptors. Pharmacol Rev. 2006 Dec; 58(4):798-836. Benoit G, Cooney A, Giguere V, Ingraham H, Lazar M, Muscat G, Perlmann T, Renaud JP, Schwabe J, Sladek F, Tsai MJ, Laudet V. PMID: 17132856.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    49. Diminished hypothalamic bdnf expression and impaired VMH function are associated with reduced SF-1 gene dosage. J Comp Neurol. 2006 Oct 10; 498(5):637-48. Tran PV, Akana SF, Malkovska I, Dallman MF, Parada LF, Ingraham HA. PMID: 16917842.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    50. Orphan nuclear receptors adopted by crystallography. Curr Opin Struct Biol. 2005 Dec; 15(6):708-15. Ingraham HA, Redinbo MR. PMID: 16263271.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    51. The DEAD-box protein DP103 (Ddx20 or Gemin-3) represses orphan nuclear receptor activity via SUMO modification. Mol Cell Biol. 2005 Mar; 25(5):1879-90. Lee MB, Lebedeva LA, Suzawa M, Wadekar SA, Desclozeaux M, Ingraham HA. PMID: 15713642; PMCID: PMC549377.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    52. Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1. Cell. 2005 Feb 11; 120(3):343-55. Krylova IN, Sablin EP, Moore J, Xu RX, Waitt GM, MacKay JA, Juzumiene D, Bynum JM, Madauss K, Montana V, Lebedeva L, Suzawa M, Williams JD, Williams SP, Guy RK, Thornton JW, Fletterick RJ, Willson TM, Ingraham HA. PMID: 15707893.
      View in: PubMed   Mentions: 188     Fields:    Translation:HumansAnimalsCells
    53. Differential requirement for steroidogenic factor-1 gene dosage in adrenal development versus endocrine function. Mol Endocrinol. 2004 Apr; 18(4):941-52. Bland ML, Fowkes RC, Ingraham HA. PMID: 14726490.
      View in: PubMed   Mentions: 37     Fields:    Translation:Animals
    54. 128 UPREGULATION OF WNT4 DISRUPTS TESTICULAR VASCULOGENESIS AND INHIBITS TESTOSTERONE SYNTHESIS. Journal of Investigative Medicine. 2004 Jan 1; 52(Suppl 1):s101. Vilain VE, Shen SJ, Olaso OR, Ingraham IH, Jordan JB. .
      View in: Publisher Site   Mentions:
    55. UPREGULATION OF WNT4 DISRUPTS TESTICULAR VASCULOGENESIS AND INHIBITS TESTOSTERONE SYNTHESIS.: 128. Journal of Investigative Medicine. 2004 Jan 1; 52:s101. Vilain VE, Shen SJ, Olaso OR, Ingraham IH, Jordan JB. .
      View in: Publisher Site   Mentions:
    56. Wnt4 overexpression disrupts normal testicular vasculature and inhibits testosterone synthesis by repressing steroidogenic factor 1/beta-catenin synergy. Proc Natl Acad Sci U S A. 2003 Sep 16; 100(19):10866-71. Jordan BK, Shen JH, Olaso R, Ingraham HA, Vilain E. PMID: 12949260; PMCID: PMC196894.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansCells
    57. Steroidogenic factor-1 and the gonadotrope-specific element enhance basal and pituitary adenylate cyclase-activating polypeptide-stimulated transcription of the human glycoprotein hormone alpha-subunit gene in gonadotropes. Mol Endocrinol. 2003 Nov; 17(11):2177-88. Fowkes RC, Desclozeaux M, Patel MV, Aylwin SJ, King P, Ingraham HA, Burrin JM. PMID: 12920232.
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    58. Structural basis for ligand-independent activation of the orphan nuclear receptor LRH-1. Mol Cell. 2003 Jun; 11(6):1575-85. Sablin EP, Krylova IN, Fletterick RJ, Ingraham HA. PMID: 12820970.
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    59. Tissue growth and remodeling of the embryonic and adult adrenal gland. Ann N Y Acad Sci. 2003 May; 995:59-72. Bland ML, Desclozeaux M, Ingraham HA. PMID: 12814939.
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    60. Requirement of the orphan nuclear receptor SF-1 in terminal differentiation of ventromedial hypothalamic neurons. Mol Cell Neurosci. 2003 Apr; 22(4):441-53. Tran PV, Lee MB, Marín O, Xu B, Jones KR, Reichardt LF, Rubenstein JR, Ingraham HA. PMID: 12727442; PMCID: PMC2710097.
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    61. Thyroid hormone receptor-beta mutations conferring hormone resistance and reduced corepressor release exhibit decreased stability in the N-terminal ligand-binding domain. Mol Endocrinol. 2003 Jan; 17(1):107-16. Huber BR, Desclozeaux M, West BL, Cunha-Lima ST, Nguyen HT, Baxter JD, Ingraham HA, Fletterick RJ. PMID: 12511610.
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    62. Regulation of the orphan nuclear receptor steroidogenic factor 1 by Sox proteins. Mol Endocrinol. 2002 Mar; 16(3):529-40. Shen JH, Ingraham HA. PMID: 11875113.
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    63. Involvement of a matrix metalloproteinase in MIS-induced cell death during urogenital development. Development. 2002 Mar; 129(6):1487-96. Roberts LM, Visser JA, Ingraham HA. PMID: 11880357.
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    64. Anti-Müllerian hormone inhibits initiation of primordial follicle growth in the mouse ovary. Endocrinology. 2002 Mar; 143(3):1076-84. Durlinger AL, Gruijters MJ, Kramer P, Karels B, Ingraham HA, Nachtigal MW, Uilenbroek JT, Grootegoed JA, Themmen AP. PMID: 11861535.
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    65. The serine/threonine transmembrane receptor ALK2 mediates Müllerian inhibiting substance signaling. Mol Endocrinol. 2001 Jun; 15(6):936-45. Visser JA, Olaso R, Verhoef-Post M, Kramer P, Themmen AP, Ingraham HA. PMID: 11376112.
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    66. Müllerian inhibitory substance induces growth of rat preantral ovarian follicles. Biol Reprod. 2001 Jan; 64(1):293-8. McGee EA, Smith R, Spears N, Nachtigal MW, Ingraham H, Hsueh AJ. PMID: 11133686.
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    67. Upregulation of Wnt4 Disrupts Testicular Vasculogenesis and Inhibits Testosterone Synthesis. Journal of Investigative Medicine. 2001 Jan 1; 52(1_suppl_part_1):101-101. Vilain VE, Shen SJ, Olaso OR, Ingraham IH, Jordan JB. .
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    68. Haploinsufficiency of steroidogenic factor-1 in mice disrupts adrenal development leading to an impaired stress response. Proc Natl Acad Sci U S A. 2000 Dec 19; 97(26):14488-93. Bland ML, Jamieson CA, Akana SF, Bornstein SR, Eisenhofer G, Dallman MF, Ingraham HA. PMID: 11121051; PMCID: PMC18946.
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    69. SF-1 and DAX-1: A Dynamic Duo in Endocrine Development Mark W. Nachtigal,. Gene Engineering in Endocrinology. 2000 Apr 1; 22:153-166. Enyeart-VanHouten ED, Ingraham IH. .
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    70. Autocrine and paracrine Müllerian inhibiting substance hormone signaling in reproduction. Recent Prog Horm Res. 2000; 55:53-67; discussion 67-8. Ingraham HA, Hirokawa Y, Roberts LM, Mellon SH, McGee E, Nachtigal MW, Visser JA. PMID: 11036933.
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    71. SF-1 and DAX-1. Gene Engineering in Endocrinology. 2000 Jan 1; 153-166. Nachtigal NM, Enyeart-VanHouten ED, Ingraham IH. .
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    72. New solutions to an ancient riddle: defining the differences between Adam and Eve. Am J Hum Genet. 1999 Oct; 65(4):933-42. Roberts LM, Shen J, Ingraham HA. PMID: 10486311; PMCID: PMC1288263.
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    73. Steroidogenic factor-1: its role in endocrine organ development and differentiation. Front Neuroendocrinol. 1999 Jul; 20(3):199-223. Hammer GD, Ingraham HA. PMID: 10433862.
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    74. Phosphorylation of the nuclear receptor SF-1 modulates cofactor recruitment: integration of hormone signaling in reproduction and stress. Mol Cell. 1999 Apr; 3(4):521-6. Hammer GD, Krylova I, Zhang Y, Darimont BD, Simpson K, Weigel NL, Ingraham HA. PMID: 10230405.
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    75. Paracrine-mediated apoptosis in reproductive tract development. Dev Biol. 1999 Apr 01; 208(1):110-22. Roberts LM, Hirokawa Y, Nachtigal MW, Ingraham HA. PMID: 10075845.
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    76. Raging Hormones in Development and Cancer Hormones and Growth Factors in Development and Neoplasia By Robert B. Dickson and David S. Salomon New York: Wiley (1998). 461 pp. $125.00. Cell. 1999 Feb 1; 96(4):476-477. Ingraham IH, Hammer HG. .
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    77. Neuronal expression of the 5HT3 serotonin receptor gene requires nuclear factor 1 complexes. J Neurosci. 1998 Aug 15; 18(16):6186-94. Bedford FK, Julius D, Ingraham HA. PMID: 9698312; PMCID: PMC6793193.
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    78. Wilms' tumor 1 and Dax-1 modulate the orphan nuclear receptor SF-1 in sex-specific gene expression. Cell. 1998 May 01; 93(3):445-54. Nachtigal MW, Hirokawa Y, Enyeart-VanHouten DL, Flanagan JN, Hammer GD, Ingraham HA. PMID: 9590178.
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    79. The nuclear receptor SF-1 mediates sexually dimorphic expression of Mullerian Inhibiting Substance, in vivo. Development. 1997 May; 124(9):1799-807. Giuili G, Shen WH, Ingraham HA. PMID: 9165127.
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    80. Bioactivation of Müllerian inhibiting substance during gonadal development by a kex2/subtilisin-like endoprotease. Proc Natl Acad Sci U S A. 1996 Jul 23; 93(15):7711-6. Nachtigal MW, Ingraham HA. PMID: 8755541; PMCID: PMC38812.
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    81. Molecular biology of pituitary development and disease. Horm Res. 1996; 45 Suppl 1:19-21. Bedford FK, Christopherson K, Nachtigal MW, Shen WH, Julius DJ, Ingraham HA. PMID: 8805023.
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    82. The nuclear receptor steroidogenic factor 1 acts at multiple levels of the reproductive axis. Genes Dev. 1994 Oct 01; 8(19):2302-12. Ingraham HA, Lala DS, Ikeda Y, Luo X, Shen WH, Nachtigal MW, Abbud R, Nilson JH, Parker KL. PMID: 7958897.
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    83. Nuclear receptor steroidogenic factor 1 regulates the müllerian inhibiting substance gene: a link to the sex determination cascade. Cell. 1994 Jun 03; 77(5):651-61. Shen WH, Moore CC, Ikeda Y, Parker KL, Ingraham HA. PMID: 8205615.
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    84. Developmental expression of mouse steroidogenic factor-1, an essential regulator of the steroid hydroxylases. Mol Endocrinol. 1994 May; 8(5):654-62. Ikeda Y, Shen WH, Ingraham HA, Parker KL. PMID: 8058073.
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    85. PIT-1 AND ITS NATURALLY OCCURRING GENETIC MUTATIONS; ANSWERS AND QUESTIONS ABOUT THE MOLECULAR BIOLOGY OF PITUITARY DEVELOPMENT AND DISEASE. Pediatric Research. 1993 May 1; 33(Suppl 5):s1-s1. Ingraham IH. .
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    86. Mutation of the POU-specific domain of Pit-1 and hypopituitarism without pituitary hypoplasia. Science. 1992 Aug 21; 257(5073):1118-21. Pfäffle RW, DiMattia GE, Parks JS, Brown MR, Wit JM, Jansen M, Van der Nat H, Van den Brande JL, Rosenfeld MG, Ingraham HA. PMID: 1509263.
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    87. Structural analysis of the transmembrane domain of the epidermal growth factor receptor. J Biol Chem. 1991 Mar 25; 266(9):5750-5. Carpenter CD, Ingraham HA, Cochet C, Walton GM, Lazar CS, Sowadski JM, Rosenfeld MG, Gill GN. PMID: 2005111.
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    88. Autoregulation of pit-1 gene expression mediated by two cis-active promoter elements. Nature. 1990 Aug 09; 346(6284):583-6. Chen RP, Ingraham HA, Treacy MN, Albert VR, Wilson L, Rosenfeld MG. PMID: 2142999.
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    89. Mutational removal of the Thr669 and Ser671 phosphorylation sites alters substrate specificity and ligand-induced internalization of the epidermal growth factor receptor. J Biol Chem. 1990 Aug 05; 265(22):12820-7. Heisermann GJ, Wiley HS, Walsh BJ, Ingraham HA, Fiol CJ, Gill GN. PMID: 2115882.
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    90. The POU-specific domain of Pit-1 is essential for sequence-specific, high affinity DNA binding and DNA-dependent Pit-1-Pit-1 interactions. Cell. 1990 Jun 15; 61(6):1021-33. Ingraham HA, Flynn SE, Voss JW, Albert VR, Kapiloff MS, Wilson L, Rosenfeld MG. PMID: 2350782.
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    91. Pituitary cell phenotypes involve cell-specific Pit-1 mRNA translation and synergistic interactions with other classes of transcription factors. Genes Dev. 1990 May; 4(5):695-711. Simmons DM, Voss JW, Ingraham HA, Holloway JM, Broide RS, Rosenfeld MG, Swanson LW. PMID: 2379827.
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    92. A family of POU-domain and Pit-1 tissue-specific transcription factors in pituitary and neuroendocrine development. Annu Rev Physiol. 1990; 52:773-91. Ingraham HA, Albert VR, Chen RP, Crenshaw 3d EB, Elsholtz HP, He X, Kapiloff MS, Mangalam HJ, Swanson LW, Treacy MN, et al. PMID: 2184776.
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    93. Expression of a large family of POU-domain regulatory genes in mammalian brain development. Nature. 1989 Jul 06; 340(6228):35-41. He X, Treacy MN, Simmons DM, Ingraham HA, Swanson LW, Rosenfeld MG. PMID: 2739723.
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    94. A pituitary POU domain protein, Pit-1, activates both growth hormone and prolactin promoters transcriptionally. Genes Dev. 1989 Jul; 3(7):946-58. Mangalam HJ, Albert VR, Ingraham HA, Kapiloff M, Wilson L, Nelson C, Elsholtz H, Rosenfeld MG. PMID: 2550324.
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    95. The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products. Genes Dev. 1988 Dec; 2(12A):1513-6. Herr W, Sturm RA, Clerc RG, Corcoran LM, Baltimore D, Sharp PA, Ingraham HA, Rosenfeld MG, Finney M, Ruvkun G, et al. PMID: 3215510.
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    96. A tissue-specific transcription factor containing a homeodomain specifies a pituitary phenotype. Cell. 1988 Nov 04; 55(3):519-29. Ingraham HA, Chen RP, Mangalam HJ, Elsholtz HP, Flynn SE, Lin CR, Simmons DM, Swanson L, Rosenfeld MG. PMID: 2902928.
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    97. Role of intrinsic protein tyrosine kinase in function and metabolism of the epidermal growth factor receptor. Cold Spring Harb Symp Quant Biol. 1988; 53 Pt 1:467-76. Gill GN, Chen WS, Lazar CS, Glenney JR, Wiley HS, Ingraham HA, Rosenfeld MG. PMID: 3254778.
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    98. Characterization of two atypical promoters and alternate mRNA processing in the mouse Thy-1.2 glycoprotein gene. Mol Cell Biol. 1986 Aug; 6(8):2923-31. Ingraham HA, Evans GA. PMID: 2878365; PMCID: PMC367861.
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    99. The mouse Thy-1.2 glycoprotein gene: complete sequence and identification of an unusual promoter. J Immunol. 1986 Feb 15; 136(4):1482-9. Ingraham HA, Lawless GM, Evans GA. PMID: 2868059.
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    100. Mechanism of thymineless death. Adv Exp Med Biol. 1986; 195 Pt B:89-95. Goulian M, Bleile BM, Dickey LM, Grafstrom RH, Ingraham HA, Neynaber SA, Peterson MS, Tseng BY. PMID: 3020930.
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    101. MECHANISM OF THYMINELESS DEATH: 73. Pediatric Research. 1985 Jul 1; 19(7):756-756. Goulian GM, Ingraham IH, Tseng TB, Dickey DL, Bleile BB, Neynaber NS. .
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    102. Expression of the Thy-1 glycoprotein gene by DNA-mediated gene transfer. Proc Natl Acad Sci U S A. 1984 Sep; 81(17):5532-6. Evans GA, Ingraham HA, Lewis K, Cunningham K, Seki T, Moriuchi T, Chang HC, Silver J, Hyman R. PMID: 6147849; PMCID: PMC391740.
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    103. Mechanism for exclusion of 5-fluorouracil from DNA. Cancer Res. 1980 Apr; 40(4):998-1001. Ingraham HA, Tseng BY, Goulian M. PMID: 6101994.
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    104. Characterization of the association of specific proteins with messenger ribonucleic acid. Biochemistry. 1976 Aug 10; 15(16):3523-8. Barrieux A, Ingraham HA, Nystul S, Rosenfeld MG. PMID: 952875.
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