Leslie Benet, PhD

Title(s)Professor, Bioengineering
SchoolSchool of Pharmacy
Address513 Parnassus Avenue, MSB, #822B
San Francisco CA 94117
Phone415-476-3853
ORCID ORCID Icon0000-0002-9678-2371 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPh.D.1965 Graduate Division (Pharmaceutical Chemistry)
    Collapse Awards and Honors
    American Pharmacists Association Academy of Pharmaceutical Research and Science (APhA-APRS),20132013 APhA-APRS Ebert Prize
    American Association of Pharmaceutical Scientists2013AAPS Journal Manuscript Award for the Most Outstanding Manuscript
    International Pharmaceutical Federation, The Netherlands2012Honorary Member
    University of Michigan2011Doctor of Science, honoris causa
    National Research Council 2011Named “National Associate”
    American College of Clinical Pharmacology, 40th Annual Meeting, Chicago, IL 2011Distinguished Investigator Award
    Controlled Release Society 2010Elected Fellow
    Catholic University of Leuven, Leuven, Belgium 2010Doctor of Philosophy, honoris causa
    American Society for Clinical Pharmacology and Therapeutics 111th Annual Meeting, Atlanta, Georgia 2010Oscar B. Hunter Memorial Award in Therapeutics
    100th Anniversary of the Nobel Prize Awarded to Paul Ehrlich, Nürnberg, Germany2008Paul Ehrlich Magic-Bullet Award 2008 Lifetime Achievement
    University of California San Francisco2007UCSF 7th Distinguished Clinical Research Lecturer
    Institute for Scientific Information2003ISI Highly Cited Researcher
    of Medical Countermeasures Against Biological Warfare Agents 2002  - 2004Chair, IOM/NRC Committee on Accelerating the Research, Development and Acquisition
    International Pharmaceutical Federation2001Høst-Madsen Medal
    Sichuan University, Sichuan Province, China2014  - 2019Guest Professorship
    Zhengzhou University, Henan Province, China2012Visiting Professor of the First Clinical Medical College of Zhengzhou University, and the Institute
    University of Wisconsin2013Busse Lecture
    NRPB – AAPS Workshop on Clinical and Diagnostic Biomarkers, Taipei, Taiwan2012Invited Keynote Lecture
    Texas Tech University Health Science Center School of Pharmacy Research Days, Texas Tech University2012Invited Keynote Lecture
    Chinese Society of Clinical Pharmacy, Zhengzhou, China2012Honorary Member
    CPSA Shanghai 2012: From Bench to Decision Making – From Basics to Applications, Shanghai, China 2012Invited Plenary Lecture
    International Symposium on Past, Present and Future Molecular Pharmacokinetics, Tokyo, Japan 2012Invited Plenary Lecture
    Horace Rackham School of Graduate Studies, University of Michigan2011Inaugural Albert B. Prescott Distinguished Lecture
    State University of New York at Buffalo2011Gerhard Levy Distinguished Lectureship in Pharmaceutical Sciences
    Biomedical Centre, Uppsala University, Uppsala, Sweden 2011Invited Plenary Lecture, Symposium
    AstraZeneca Research & Development Mölndal, Sweden 2011The AstraZeneca Drug Hunting Lecture
    Thompson Reuters Highly Cited Researcher20141 of 16 pharmacologists worldwide to be listed in both 2001 and 2014 compilations
    2010 Pharmaceutical Sciences World Congress and the AAPS Annual Meeting and Exposition, New Orleans,2010Invited Plenary Lecture
    The 42nd Annual Pharmaceutics Graduate Student Research Meeting (PGSRM), The Ohio State University2010Invited Keynote Lecture
    18th International Symposium on Microsomes and Drug Oxidations, Beijing, China 2010Invited Plenary Lecture
    129th Annual Meeting of the Pharmaceutical Society of Japan, Kyoto, Japan 2009Invited Plenary Lecture
    University of Athens, Greece 2005Doctor of Philosophy, honoris causa
    9th International Symposium of the Controlled Release Society Indian Chapter, Mumbai, India2009Invited Plenary Lecture
    100th Anniversary of School of Pharmacy, NDMC; 2008 PST & TSHP Joint International Conference2008Invited Keynote Speaker
    2008National Defense Medical Center, Taipei
    2008Nagai Foundation Tokyo Distinguished Lectureship 2008
    28th Annual Meeting of the Japanese Society for Drug Delivery Systems, Tokyo, Japan2008Invited Plenary Lecture
    Modified Release Forum, West Point, PA 2008Invited Plenary Lecture
    109th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics2008Invited Featured Speaker
    iMED.UL (Research Institute for Medicines and Pharmaceutical Sciences) University of Lisbon, Portuga2008Chair, Scientific Advisory Board
    8th International Symposium on Advances in Technology & Business Potential of New Drug Delivery Syst2008Keynote Lecture
    Japan Society for the Study of Xenobiotics, Sendai, Japan 2007International Honorary Member
    University of Michigan College of Pharmacy, Ann Arbor, MI 2007Graduation Speaker
    Division of Biocomputing, School of Medicine, University of New Mexico2007Keynote Lecture, Biocomputing Day
    Meeting of the European Drug Absorption Network, Leuven, Belgium 2007Keynote Lecture
    7th International Symposium on Advances in Technology and Business Potential of New Drug Delivery Sy2007Plenary Lecture
    4th International COE Symposium, Target Validation, Lead Optimization & Clinical Development, Tokyo2006Plenary Lecture
    16th International Symposium on Microsomes and Drug Oxidation, Budapest2006Plenary Lecture
    Gordon Research Conference on Drug Metabolism, Plymouth, NH 2006Chair
    Great Lakes Symposium 2006, Buffalo, NY 2006Keynote Address
    Journees Galeniques de Saint-Remy de Provence, Saint-Remy, France 2006Plenary Lecture
    Canadian Society for Pharmaceutical Sciences 9th Annual International Symposium on Pharmaceutical Sc2006Plenary Lecture
    Analytica Conference 2006, Munich, Germany 2006Plenary Lecture
    British Pharmaceutical Conference, Manchester, UK 2005Keynote Address
    2nd International Symposium on Scientific & Regulatory Aspects of Dissolution & Bioequivalence2005Plenary Lecture
    9th International Congress of Therapeutic Drug Monitoring & Clinical Toxicology2005Plenary Lecture
    Controlled Release Society 2004 Annual Meeting & Exposition2004Career Achievement Award in Oral Drug Delivery
    Pharmaceutical Sciences World Congress 2004, Kyoto2004Research Achievement Award in Pharmaceutical Sciences
    Romanian Academy of Medical Sciences2003Invested as a “Member of Honour”
    First Congress of the Portuguese Society for Pharmaceutical Sciences2003Opening Plenary Lecture
    International Pharmaceutical Technology Symposium 2002, Istanbul, Turkey 2002Plenary Lecture
    Academia de Ciencias Farmacéuticas de Chile, Santiago, Chile 2002Invested as a “Miembro Honorario”
    10th International Conference on Pharmaceutical Technology, Florence, Italy 2002Plenary Lecture
    American Association of Indian Pharmaceutical Scientists2001Elected Fellow
    FDA/CDER and ASCPT2015William B. Abrams Lectureship
    Medical Technology Schools2015Listed among "25 Top Pharmacy Professors" in the U.S.A.
    Thomson Reuters2014Highly cited Researcher-Pharmacology
    Medical Technology Schools2015"25 Top Pharmacy Professors" in USA
    FDA/CDER and American Society for Clinical Pharmacology and Therapeutics2015William B. Abrams Lectureship
    International Society for the Study of Xenobiotics2015North American Scientific Achievement Award
    American Pharmacists Association2016Remington Honor Medal
    University of Lisbon, Portugal2016Doctor of Philosophy, honoris causa

    Collapse Overview 
    Collapse Overview
    Dr. Benet, Professor and former Chairman (1978-1998), Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California, San Francisco, received his A.B. (English), B.S. (Pharmacy), M.S. from the University of Michigan and Ph.D. from the University of California. He has received nine honorary doctorates: Uppsala University, Sweden (Pharm.D., 1987), Leiden University, The Netherlands (Ph.D., 1995), University of Illinois at Chicago (D.Sc., 1997), Philadelphia College of Pharmacy and Science (D.Sc., 1997), Long Island University (D.Sc., 1999), University of Athens, Greece (Ph.D., 2005), Catholic University of Leuven, Belgium (Ph.D., 2010), University of Michigan (D.Sc., 2011) and University of Lisbon, Portugal (Ph.D., 2016). His research interests, more than 620 publications, 7 books and 12 patents are in the areas of pharmacokinetics, biopharmaceutics, drug delivery and pharmacodynamics. Dr. Benet is listed by Clarivate Analytics as one of the most highly cited pharmacologists worldwide with his published peer-reviewed papers cited over 33,000 times, while Google Scholar credits him with over 50,000 citations. His most recent work has addressed the deficiencies of in vitro-in vivo extrapolation (IVIVE) and different approaches to advancing our understanding and prediction of clearance processes. Dr. Benet was a Founder/Editor of the JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS (1973-98) and Associate Editor of PHARMACOLOGY AND THERAPEUTICS (1995-2000). He presently serves a member of the Editorial boards of PHARMACOLOGY and AAPS JOURNAL. He is a Fellow of the American Association for the Advancement of Science (AAAS), the American Association of Pharmaceutical Scientists (AAPS), the American College of Clinical Pharmacology (ACCP) and the Controlled Release Society (CRS). In 1982, Dr. Benet received the APhA Academy of Pharmaceutical Sciences (APS) Research Achievement Award in Pharmaceutics and the University of Michigan, College of Pharmacy, Distinguished Alumnus Award. In 1985, he served as President of APS. During 1986, Dr. Benet was a Founder and first President of the AAPS. In 1987, Dr. Benet was elected to membership in the National Academy of Medicine (NAM) of the U.S. National Academy of Sciences. In 1988, he received the ACCP Distinguished Service Award and in 1989, the AAPS Distinguished Pharmaceutical Scientist Award. In 1990, he was the recipient of the Rho Chi Lecture Award, and the UCSF Long Teaching Award, while in 1991, he received the Volwiler Research Achievement Award of the American Association of Colleges of Pharmacy (AACP). In 1993-94, he served as AACP President. In 1995, he received the Rawls-Palmer Progress in Medicine Award of the American Society for Clinical Pharmacology and Therapeutics (ASCPT); in 1996, the AAPS Distinguished Service Award; and in 2000 the APhA Takeru Higuchi Research Prize and the AAPS Wurster Research Award in Pharmaceutics. In 2001 he was awarded the Høst-Madsen Medal of the International Pharmaceutical Federation (FIP) and the UCSF Outstanding Faculty Mentorship Award (repeated in 2016). In 2004, he was awarded the Pharmaceutical Sciences World Congress Research Achievement Award and the CRS Career Achievement in Oral Drug Delivery Award. In 2007 he was selected as the UCSF Distinguished Clinical Research Lecturer; in 2010, the ASCPT Hunter Memorial Award in Therapeutics; and in 2011 the ACCP Distinguished Investigator award. In 2012, the September issue of PHARMACEUTICAL RESEARCH was dedicated in his honor and he was made an honorary member of FIP. In 2013, he was awarded the APhA Ebert Prize, the AAPS Journal Outstanding Manuscript award and the September issue of JOURNAL OF PHARMACEUTICAL SCIENCES was dedicated in his honor. In 2015 he received the ISSX North American Scientific Achievement award; in 2016 the Remington Honor Medal from the APhA, the highest honor in American Pharmacy; and in 2017 a full day symposium in his honor entitled “The Cutting Edge in Pharmaceutical Sciences—50 Years of Progress Celebrating Les Benet’s 80th Birthday” was held in conjunction with the Pharmaceutical Sciences World Congress in Stockholm, Sweden. In 2023 he received the Lifetime Achievement Award of the Frankfurt Foundation for the Quality of Medicines. Dr. Benet formerly served as Chair of the Pharmacology Study Section and the Pharmacological Sciences Review Committee for the NIH, the FDA CBER Peer Review Committee, the FDA Expert Panel on Individual Bioequivalence, the Board of Pharmaceutical Sciences of the FIP, the Organizing Committee for the FIP Millennial World Congress of Pharmaceutical Sciences, the Congressionally mandated NAM/National Research Council (NRC) Committee on Accelerating the Research, Development and Acquisition of Medical Countermeasures Against Biological Warfare Agents and the FIP Foundation for Education and Research and as a member of the FDA Science Board, the FDA Generic Drugs Advisory Committee and the NRC Biodefense Standing Committee. He presently serves as Chair of the Board of Directors of Medicines360, a nonprofit pharmaceutical company, emphasizing products for women’s health. July 2023
    Collapse Websites

    Collapse Research 
    Collapse Research Activities and Funding
    A novel mechanistic modeling platform for predicting drug clearance and disposition mediated by transporters and enzymes
    NIH R43GM113597Jan 15, 2015 - Oct 14, 2015
    Role: Co-Principal Investigator
    A Transporter-Based Predictive ADME Platform
    NIH R43RR031474May 15, 2010 - May 14, 2011
    Role: Principal Investigator
    Transporter-Enzyme Interplay Evaluation via Microfluidiic HTS Cell Culture Device
    NIH R21GM075900Jun 2, 2006 - May 31, 2009
    Role: Principal Investigator
    GENDER EFFECTS ON HIV BIOLOGY
    NIH P01HD040543Apr 23, 2001 - Mar 31, 2008
    Role: Co-Investigator
    MOLECULAR BASIS OF DRUG TRANSPORT IN THE INTESTINE
    NIH R01GM057656Aug 1, 1997 - Jul 31, 2001
    Role: Co-Principal Investigator
    Proteases in Cancer Biology and Drug Development
    NIH P01CA072006Jun 10, 1997 - Jun 30, 2010
    Role: Co-Investigator
    ACYLCOA FORMATION--COVALENT BINDING, PHARMACOKINETICS
    NIH R01GM036633Apr 1, 1986 - Mar 31, 2004
    Role: Principal Investigator
    SCIENTIFIC REVIEW AND EVALUATION AWARD - PHARMACOLOGICAL
    NIH U09GM007709Nov 1, 1984 - Jul 31, 1991
    Role: Co-Principal Investigator
    NITROGLYCERIN DINITRATE METABOLITES--KINETICS/DYNAMICS
    NIH R01HL032243Apr 1, 1984 - Dec 31, 1991
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator
    PHARMACOKINETICS/PHARMACODYNAMICS
    NIH P50GM026691Aug 1, 1979 - Jul 31, 1998
    Role: Principal Investigator
    General Clinical Research Center
    NIH M01RR000079Dec 1, 1974 - Mar 31, 2009
    Role: Co-Investigator

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    Collapse Clinical Trials
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    Collapse Featured Content 
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Are all measures of liver Kpuu a function of FH, as determined following oral dosing, or have we made a critical error in defining hepatic drug clearance? Eur J Pharm Sci. 2024 Mar 22; 196:106753. Benet LZ, Sodhi JK. PMID: 38522769.
      View in: PubMed   Mentions:    Fields:    
    2. An Explanation of Why Dose-Corrected Area Under the Curve for Alternate Administration Routes Can Be Greater than for Intravenous Dosing. AAPS J. 2024 Jan 30; 26(1):22. Wakuda H, Xiang Y, Sodhi JK, Uemura N, Benet LZ. PMID: 38291293.
      View in: PubMed   Mentions:    Fields:    
    3. Solubility-Permeability Interplay in Facilitating the Prediction of Drug Disposition Routes, Extent of Absorption, Food Effects, Brain Penetration and Drug Induced Liver Injury Potential. J Pharm Sci. 2023 09; 112(9):2326-2331. Benet LZ. PMID: 37429358.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. The Uses and Advantages of Kirchhoff's Laws vs. Differential Equations in Pharmacology, Pharmacokinetics, and (Even) Chemistry. AAPS J. 2023 04 10; 25(3):38. Benet LZ, Sodhi JK. PMID: 37038013; PMCID: PMC10832327.
      View in: PubMed   Mentions: 2     Fields:    
    5. Using an animal model to predict the effective human dose for oral multiple sclerosis drugs. Clin Transl Sci. 2023 03; 16(3):467-477. Liu W, Yu Z, Wang Z, Waubant EL, Zhai S, Benet LZ. PMID: 36419359; PMCID: PMC10014696.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    6. Review of the application of Kirchhoff's Laws of series and parallel flows to pharmacology: Defining organ clearance. Pharmacol Ther. 2022 Nov; 239:108278. Pachter JA, Dill KA, Sodhi JK, Benet LZ. PMID: 36075300; PMCID: PMC10832328.
      View in: PubMed   Mentions: 3     Fields:    
    7. State of the Art and Uses for the Biopharmaceutics Drug Disposition Classification System (BDDCS): New Additions, Revisions, and Citation References. AAPS J. 2022 02 23; 24(2):37. Bocci G, Oprea TI, Benet LZ. PMID: 35199251; PMCID: PMC8865883.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    8. Does Addition of Protein to Hepatocyte or Microsomal In Vitro Incubations Provide a Useful Improvement in In Vitro-In Vivo Extrapolation Predictability? Drug Metab Dispos. 2022 04; 50(4):401-412. Kameyama T, Sodhi JK, Benet LZ. PMID: 35086847.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    9. Can In Vitro-In Vivo Extrapolation Be Successful? Recognizing the Incorrect Clearance Assumptions. Clin Pharmacol Ther. 2022 05; 111(5):1022-1035. Benet LZ, Sodhi JK. PMID: 34731496; PMCID: PMC9542026.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    10. Analyzing Potential Intestinal Transporter Drug-Drug Interactions: Reevaluating Ticagrelor Interaction Studies. Pharm Res. 2021 Oct; 38(10):1639-1644. Liu S, Sodhi JK, Benet LZ. PMID: 34729703; PMCID: PMC9595044.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    11. Batch Selection via In Vitro/In Vivo Correlation in Pharmacokinetic Bioequivalence Testing. AAPS PharmSciTech. 2021 Aug 19; 22(7):224. Burmeister Getz E, Carroll KJ, Mielke J, Jones B, Benet LZ. PMID: 34410534.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    12. Examination of Urinary Excretion of Unchanged Drug in Humans and Preclinical Animal Models: Increasing the Predictability of Poor Metabolism in Humans. Pharm Res. 2021 Jul; 38(7):1139-1156. Bamfo NO, Hosey-Cojocari C, Benet LZ, Remsberg CM. PMID: 34254223.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    13. Effects of Single Dose Rifampin on the Pharmacokinetics of Fluvastatin in Healthy Volunteers. Clin Pharmacol Ther. 2021 08; 110(2):480-485. Xiang Y, Okochi H, Kozachenko I, Sodhi JK, Frassetto LA, Benet LZ. PMID: 33880760; PMCID: PMC9648157.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    14. There is Only One Valid Definition of Clearance: Critical Examination of Clearance Concepts Reveals the Potential for Errors in Clinical Drug Dosing Decisions. AAPS J. 2021 05 10; 23(3):67. Benet LZ, Sodhi JK, Makrygiorgos G, Mesbah A. PMID: 33973074; PMCID: PMC8110503.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    15. Investigating Intestinal Transporter Involvement in Rivaroxaban Disposition through Examination of Changes in Absorption. Pharm Res. 2021 May; 38(5):795-801. Kou W, Sodhi JK, Wu X, Benet LZ. PMID: 33847849; PMCID: PMC8501891.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    16. Tenofovir and emtricitabine concentrations in hair are comparable between individuals on tenofovir disoproxil fumarate versus tenofovir alafenamide-based ART. Drug Test Anal. 2021 Jul; 13(7):1354-1370. Okochi H, Louie A, Phung N, Zhang K, Tallerico RM, Kuncze K, Spinelli MA, Koss CA, Benet LZ, Gandhi M. PMID: 33742745; PMCID: PMC9131373.
      View in: PubMed   Mentions: 1  Translation:Humans
    17. Using Individualized Patient Data for Prediction of Population Dosing Recommendations Versus Predictions of Individualized Patient Dosing. J Clin Pharmacol. 2021 06; 61(6):734-735. Benet LZ. PMID: 33742720.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    18. Successful and Unsuccessful Prediction of Human Hepatic Clearance for Lead Optimization. J Med Chem. 2021 04 08; 64(7):3546-3559. Sodhi JK, Benet LZ. PMID: 33765384; PMCID: PMC8504179.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    19. Volume of Distribution is Unaffected by Metabolic Drug-Drug Interactions. Clin Pharmacokinet. 2021 02; 60(2):205-222. Sodhi JK, Huang CH, Benet LZ. PMID: 32725383; PMCID: PMC7385331.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    20. Intestinal Efflux Transporters P-gp and BCRP Are Not Clinically Relevant in Apixaban Disposition. Pharm Res. 2020 Sep 29; 37(10):208. Sodhi JK, Liu S, Benet LZ. PMID: 32996065; PMCID: PMC7936879.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    21. Investigating the Theoretical Basis for In Vitro-In Vivo Extrapolation (IVIVE) in Predicting Drug Metabolic Clearance and Proposing Future Experimental Pathways. AAPS J. 2020 09 10; 22(5):120. Benet LZ, Sodhi JK. PMID: 32914238; PMCID: PMC7515557.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    22. The Critical Role of Passive Permeability in Designing Successful Drugs. ChemMedChem. 2020 10 19; 15(20):1862-1874. Di L, Artursson P, Avdeef A, Benet LZ, Houston JB, Kansy M, Kerns EH, Lennernäs H, Smith DA, Sugano K. PMID: 32743945.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    23. The Necessity of Using Changes in Absorption Time to Implicate Intestinal Transporter Involvement in Oral Drug-Drug Interactions. AAPS J. 2020 08 17; 22(5):111. Sodhi JK, Benet LZ. PMID: 32808084; PMCID: PMC7478332.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    24. A Simple Methodology to Differentiate Changes in Bioavailability From Changes in Clearance Following Oral Dosing of Metabolized Drugs. Clin Pharmacol Ther. 2020 08; 108(2):306-315. Sodhi JK, Benet LZ. PMID: 32150643; PMCID: PMC7478330.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    25. Are There Any Experimental Perfusion Data that Preferentially Support the Dispersion and Parallel-Tube Models over the Well-Stirred Model of Organ Elimination? Drug Metab Dispos. 2020 07; 48(7):537-543. Sodhi JK, Wang HJ, Benet LZ. PMID: 32305951; PMCID: PMC7289046.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    26. Predicting Interactions between Rifampin and Antihypertensive Drugs Using the Biopharmaceutics Drug Disposition Classification System. Pharmacotherapy. 2020 04; 40(4):274-290. Liu W, Yan T, Chen K, Yang L, Benet LZ, Zhai S. PMID: 32100890.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    27. Challenging the Relevance of Unbound Tissue-to-Blood Partition Coefficient (Kpuu) on Prediction of Drug-Drug Interactions. Pharm Res. 2020 Mar 25; 37(4):73. Sodhi JK, Liu S, Benet LZ. PMID: 32215750; PMCID: PMC7518636.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    28. Late-Stage Failures of Monoclonal Antibody Drugs: A Retrospective Case Study Analysis. Pharmacology. 2020; 105(3-4):145-163. Sun A, Benet LZ. PMID: 31910414.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    29. Can BDDCS illuminate targets in drug design? Drug Discov Today. 2019 12; 24(12):2299-2306. Bocci G, Benet LZ, Oprea TI. PMID: 31585170; PMCID: PMC7002033.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    30. Protein Binding and Hepatic Clearance: Re-Examining the Discrimination between Models of Hepatic Clearance with Diazepam in the Isolated Perfused Rat Liver Preparation. Drug Metab Dispos. 2019 12; 47(12):1397-1402. Wang HJ, Benet LZ. PMID: 31563869; PMCID: PMC7042717.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    31. In Vitro-In Vivo Inaccuracy: The CYP3A4 Anomaly. Drug Metab Dispos. 2019 12; 47(12):1368-1371. Bowman CM, Benet LZ. PMID: 31551322; PMCID: PMC7042718.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    32. Food, Acid Supplementation and Drug Absorption - a Complicated Gastric Mix: a Randomized Control Trial. Pharm Res. 2019 Sep 04; 36(11):155. Surofchy DD, Frassetto LA, Benet LZ. PMID: 31485804; PMCID: PMC7484952.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    33. How Transporters Have Changed Basic Pharmacokinetic Understanding. AAPS J. 2019 09 03; 21(6):103. Benet LZ, Bowman CM, Sodhi JK. PMID: 31482335; PMCID: PMC7241423.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    34. The Enhancement of Subcutaneous First-Pass Metabolism Causes Nonlinear Pharmacokinetics of TAK-448 after a Single Subcutaneous Administration to Rats. Drug Metab Dispos. 2019 09; 47(9):1004-1012. Moriya Y, Kogame A, Tagawa Y, Morohashi A, Kondo T, Asahi S, Benet LZ. PMID: 31201213.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    35. Interlaboratory Variability in Human Hepatocyte Intrinsic Clearance Values and Trends with Physicochemical Properties. Pharm Res. 2019 May 31; 36(8):113. Bowman CM, Benet LZ. PMID: 31152241; PMCID: PMC7191673.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    36. Understanding drug-drug interaction and pharmacogenomic changes in pharmacokinetics for metabolized drugs. J Pharmacokinet Pharmacodyn. 2019 04; 46(2):155-163. Benet LZ, Bowman CM, Koleske ML, Rinaldi CL, Sodhi JK. PMID: 30911879; PMCID: PMC7179954.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    37. In Vitro-In Vivo Extrapolation and Hepatic Clearance-Dependent Underprediction. J Pharm Sci. 2019 07; 108(7):2500-2504. Bowman CM, Benet LZ. PMID: 30817922; PMCID: PMC7325626.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    38. Characterization of Fasiglifam-Related Liver Toxicity in Dogs. Drug Metab Dispos. 2019 05; 47(5):525-534. Kogame A, Moriya Y, Mori I, Pan L, Morohashi A, Ebihara T, Fukui H, Tagawa Y, Benet LZ. PMID: 30765394.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    39. The Presence of a Transporter-Induced Protein Binding Shift: A New Explanation for Protein-Facilitated Uptake and Improvement for In Vitro-In Vivo Extrapolation. Drug Metab Dispos. 2019 04; 47(4):358-363. Bowman CM, Okochi H, Benet LZ. PMID: 30674616; PMCID: PMC6413769.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    40. Evaluating Within-Subject Variability for Narrow Therapeutic Index Drugs. Clin Pharmacol Ther. 2019 02; 105(2):411-416. Jayachandran P, Okochi H, Frassetto LA, Park W, Fang L, Zhao L, Benet LZ. PMID: 30652304.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCTClinical Trials
    41. Batch-to-Batch and Within-Subject Variability: What Do We Know and How Do These Variabilities Affect Clinical Pharmacology and Bioequivalence? Clin Pharmacol Ther. 2019 02; 105(2):326-328. Benet LZ, Jayachandran P, Carroll KJ, Burmeister Getz E. PMID: 30652313.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    42. TPT sulfonate, a single, oral dose schistosomicidal prodrug: In vivo efficacy, disposition and metabolic profiling. Int J Parasitol Drugs Drug Resist. 2018 12; 8(3):571-586. Wolfe AR, Neitz RJ, Burlingame M, Suzuki BM, Lim KC, Scheideler M, Nelson DL, Benet LZ, Caffrey CR. PMID: 30503203; PMCID: PMC6287543.
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    43. The Extended Clearance Concept Following Oral and Intravenous Dosing: Theory and Critical Analyses. Pharm Res. 2018 Oct 22; 35(12):242. Benet LZ, Bowman CM, Liu S, Sodhi JK. PMID: 30349948; PMCID: PMC6364828.
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    44. Ascorbic acid metabolites are involved in intraocular pressure control in the general population. Redox Biol. 2019 01; 20:349-353. Hysi PG, Khawaja AP, Menni C, Tamraz B, Wareham N, Khaw KT, Foster PJ, Benet LZ, Spector TD, Hammond CJ. PMID: 30391827; PMCID: PMC6223183.
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    45. Development and Validation of an Immunoassay for Tenofovir in Urine as a Real-Time Metric of Antiretroviral Adherence. EClinicalMedicine. 2018 Aug-Sep; 2-3:22-28. Gandhi M, Bacchetti P, Rodrigues WC, Spinelli M, Koss CA, Drain PK, Baeten JM, Mugo NR, Ngure K, Benet LZ, Okochi H, Wang G, Vincent M. PMID: 30906930; PMCID: PMC6428441.
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    46. An examination of protein binding and protein-facilitated uptake relating to in vitro-in vivo extrapolation. Eur J Pharm Sci. 2018 Oct 15; 123:502-514. Bowman CM, Benet LZ. PMID: 30098391; PMCID: PMC6365006.
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    47. Evaluation of the Relevance of DILI Predictive Hypotheses in Early Drug Development: Review of In Vitro Methodologies vs BDDCS Classification. Toxicol Res (Camb). 2018 May 08; 7(3):358-370. Chan R, Benet LZ. PMID: 29785262; PMCID: PMC5959290.
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    48. Predicting Pharmacokinetics/Pharmacodynamics in the Individual Patient: Separating Reality From Hype. J Clin Pharmacol. 2018 Aug; 58(8):979-989. Benet LZ. PMID: 29663413.
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    49. Measures of BSEP Inhibition In Vitro Are Not Useful Predictors of DILI. Toxicol Sci. 2018 04 01; 162(2):499-508. Chan R, Benet LZ. PMID: 29272540; PMCID: PMC5888978.
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    50. A Drug-drug Interaction Between Cyclosporine and Nystatin. Clin Ther. 2018 04; 40(4):660-662. Liu W, Guan X, Yu Z, Chen K, Benet L, Zhai S. PMID: 29551534.
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    51. Development and validation of an assay to analyze atazanavir in human hair via liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom. 2018 Mar 15; 32(5):431-441. Phung N, Kuncze K, Okochi H, Louie A, Benet LZ, Ofokotun I, Haas DW, Currier JS, Chawana TD, Sheth AN, Bacchetti P, Gandhi M, Horng H. PMID: 29315954; PMCID: PMC5848502.
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    52. Why Drugs Fail in Late Stages of Development: Case Study Analyses from the Last Decade and Recommendations. AAPS J. 2018 03 13; 20(3):46. Parasrampuria DA, Benet LZ, Sharma A. PMID: 29536211.
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    53. Local delivery of hormonal therapy with silastic tubing for prevention and treatment of breast cancer. Sci Rep. 2018 01 08; 8(1):92. Park J, Thomas S, Zhong AY, Wolfe AR, Krings G, Terranova-Barberio M, Pawlowska N, Benet LZ, Munster PN. PMID: 29311658; PMCID: PMC5758798.
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    54. Comparison of Measures of Adherence to Human Immunodeficiency Virus Preexposure Prophylaxis Among Adolescent and Young Men Who Have Sex With Men in the United States. Clin Infect Dis. 2018 01 06; 66(2):213-219. Koss CA, Hosek SG, Bacchetti P, Anderson PL, Liu AY, Horng H, Benet LZ, Kuncze K, Louie A, Saberi P, Wilson CM, Gandhi M. PMID: 29020194; PMCID: PMC5850042.
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    55. The Universally Unrecognized Assumption in Predicting Drug Clearance and Organ Extraction Ratio. Clin Pharmacol Ther. 2018 03; 103(3):521-525. Benet LZ, Liu S, Wolfe AR. PMID: 28762489; PMCID: PMC6364827.
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    56. Commentary on: "Influence of OATP1B1 Function on the Disposition of Sorafenib-β-D-Glucuronide". Clin Transl Sci. 2017 07; 10(4):240-241. Morrissey KM, Benet LZ, Ware JA. PMID: 28664655; PMCID: PMC5504478.
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    57. Understanding the Potential Interethnic Difference in Rosuvastatin Pharmacokinetics. J Pharm Sci. 2017 09; 106(9):2231-2233. Benet LZ, Wu HF. PMID: 28502797.
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    58. Cellular Uptake of Levocetirizine by Organic Anion Transporter 4. J Pharm Sci. 2017 09; 106(9):2895-2898. Noguchi S, Nishimura T, Mukaida S, Benet LZ, Nakashima E, Tomi M. PMID: 28385546.
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    59. Rosuvastatin Pharmacokinetics in Asian and White Subjects Wild Type for Both OATP1B1 and BCRP Under Control and Inhibited Conditions. J Pharm Sci. 2017 09; 106(9):2751-2757. Wu HF, Hristeva N, Chang J, Liang X, Li R, Frassetto L, Benet LZ. PMID: 28385543; PMCID: PMC5675025.
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    60. Evaluation of DILI Predictive Hypotheses in Early Drug Development. Chem Res Toxicol. 2017 04 17; 30(4):1017-1029. Chan R, Benet LZ. PMID: 28257576; PMCID: PMC5674994.
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    61. Differences in Cumulative Exposure and Adherence to Tenofovir in the VOICE, iPrEx OLE, and PrEP Demo Studies as Determined via Hair Concentrations. AIDS Res Hum Retroviruses. 2017 08; 33(8):778-783. Koss CA, Bacchetti P, Hillier SL, Livant E, Horng H, Mgodi N, Mirembe BG, Gomez Feliciano K, Horn S, Liu AY, Glidden DV, Grant RM, Benet LZ, Louie A, van der Straten A, Chirenje ZM, Marrazzo JM, Gandhi M. PMID: 28253024; PMCID: PMC5564054.
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    62. Meal Effects Confound Attempts to Counteract Rabeprazole-Induced Hypochlorhydria Decreases in Atazanavir Absorption. Pharm Res. 2017 03; 34(3):619-628. Faber KP, Wu HF, Yago MR, Xu X, Kadiyala P, Frassetto LA, Benet LZ. PMID: 28028768; PMCID: PMC7179955.
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    63. Classification of natural products as sources of drugs according to the biopharmaceutics drug disposition classification system (BDDCS). Chin J Nat Med. 2016 Dec; 14(12):888-897. Li J, Larregieu CA, Benet LZ. PMID: 28262115.
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    64. Between-Batch Pharmacokinetic Variability Inflates Type I Error Rate in Conventional Bioequivalence Trials: A Randomized Advair Diskus Clinical Trial. Clin Pharmacol Ther. 2017 03; 101(3):331-340. Burmeister Getz E, Carroll KJ, Mielke J, Benet LZ, Jones B. PMID: 27727445; PMCID: PMC5324827.
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    65. Association of age, baseline kidney function, and medication exposure with declines in creatinine clearance on pre-exposure prophylaxis: an observational cohort study. Lancet HIV. 2016 11; 3(11):e521-e528. Gandhi M, Glidden DV, Mayer K, Schechter M, Buchbinder S, Grinsztejn B, Hosek S, Casapia M, Guanira J, Bekker LG, Louie A, Horng H, Benet LZ, Liu A, Grant RM. PMID: 27658870; PMCID: PMC5085869.
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    66. Hepatic Clearance Predictions from In Vitro-In Vivo Extrapolation and the Biopharmaceutics Drug Disposition Classification System. Drug Metab Dispos. 2016 11; 44(11):1731-1735. Bowman CM, Benet LZ. PMID: 27519549.
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    67. 2016 Remington Honor Medal Address: Science for the profession. J Am Pharm Assoc (2003). 2016 Jul-Aug; 56(4):365-8. Benet LZ. PMID: 27450136.
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    68. Isoniazid hair concentrations in children with tuberculosis: a proof of concept study. Int J Tuberc Lung Dis. 2016 06; 20(6):844-7. Mave V, Chandanwale A, Kinikar A, Khadse S, Kagal A, Gupte N, Suryavanshi N, Nimkar S, Koli H, Khwaja S, Bharadwaj R, Joshi S, Horng H, Benet LZ, Ramachandran G, Dooley KE, Gupta A, Gandhi M. PMID: 27155191; PMCID: PMC4889729.
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    69. BDDCS, the Rule of 5 and drugability. Adv Drug Deliv Rev. 2016 06 01; 101:89-98. Benet LZ, Hosey CM, Ursu O, Oprea TI. PMID: 27182629; PMCID: PMC4910824.
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    70. Batch-to-batch pharmacokinetic variability confounds current bioequivalence regulations: A dry powder inhaler randomized clinical trial. Clin Pharmacol Ther. 2016 Sep; 100(3):223-31. Burmeister Getz E, Carroll KJ, Jones B, Benet LZ. PMID: 27037630; PMCID: PMC5102576.
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    71. Use of the Biopharmaceutics Drug Disposition Classification System (BDDCS) to Help Predict the Occurrence of Idiosyncratic Cutaneous Adverse Drug Reactions Associated with Antiepileptic Drug Usage. AAPS J. 2016 05; 18(3):757-66. Chan R, Wei CY, Chen YT, Benet LZ. PMID: 26951484; PMCID: PMC5256615.
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    72. Reliability of In Vitro and In Vivo Methods for Predicting the Effect of P-Glycoprotein on the Delivery of Antidepressants to the Brain. Clin Pharmacokinet. 2016 Feb; 55(2):143-67. Zheng Y, Chen X, Benet LZ. PMID: 26293617; PMCID: PMC5674979.
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    73. BDDCS Predictions, Self-Correcting Aspects of BDDCS Assignments, BDDCS Assignment Corrections, and Classification for more than 175 Additional Drugs. AAPS J. 2016 Jan; 18(1):251-60. Hosey CM, Chan R, Benet LZ. PMID: 26589308; PMCID: PMC4706282.
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    74. Few Drugs Display Flip-Flop Pharmacokinetics and These Are Primarily Associated with Classes 3 and 4 of the BDDCS. J Pharm Sci. 2015 Sep; 104(9):3229-35. Garrison KL, Sahin S, Benet LZ. PMID: 26010239; PMCID: PMC4536115.
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    75. Predicting the extent of metabolism using in vitro permeability rate measurements and in silico permeability rate predictions. Mol Pharm. 2015 May 04; 12(5):1456-66. Hosey CM, Benet LZ. PMID: 25816851; PMCID: PMC4666302.
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    76. pH Dependent but not P-gp Dependent Bidirectional Transport Study of S-propranolol: The Importance of Passive Diffusion. Pharm Res. 2015 Aug; 32(8):2516-26. Zheng Y, Benet LZ, Okochi H, Chen X. PMID: 25690341; PMCID: PMC4891189.
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    77. A phase I study of targeted, dose-escalated intravenous busulfan in combination with etoposide as myeloablative therapy for autologous stem cell transplantation in acute myeloid leukemia. Clin Lymphoma Myeloma Leuk. 2015 Jun; 15(6):377-83. Mannis GN, Andreadis C, Logan AC, Damon LE, Benet LZ, Ai WZ, Gaensler KM, Kaplan LD, Koplowicz YB, Linker CA, Olin RL, Sayre PH, Smith CC, Sudhindra A, Venstrom JM, Wolf JL, Martin TG. PMID: 25776193.
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    78. Inclusion of placebos and blinding for ascending dose first-in-human studies and other underpowered phase 1 studies has not been justified and on balance is not useful. Basic Clin Pharmacol Toxicol. 2015 Jul; 117(1):44-51. Parasrampuria DA, Benet LZ. PMID: 25406995.
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    79. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014 Nov; 16(6):1358-65. Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. PMID: 25274610; PMCID: PMC4389759.
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    80. Predicting when biliary excretion of parent drug is a major route of elimination in humans. AAPS J. 2014 Sep; 16(5):1085-96. Hosey CM, Broccatelli F, Benet LZ. PMID: 25004821; PMCID: PMC4147063.
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    81. Distinguishing between the permeability relationships with absorption and metabolism to improve BCS and BDDCS predictions in early drug discovery. Mol Pharm. 2014 Apr 07; 11(4):1335-44. Larregieu CA, Benet LZ. PMID: 24628254; PMCID: PMC3983369.
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    82. Best single time point correlations with AUC for cyclosporine and tacrolimus in HIV-infected kidney and liver transplant recipients. Transplantation. 2014 Mar 27; 97(6):702-7. Frassetto LA, Tan-Tam CC, Barin B, Browne M, Wolfe AR, Stock PG, Roland M, Benet LZ. PMID: 24389906; PMCID: PMC4018220.
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    83. Mouse liver repopulation with hepatocytes generated from human fibroblasts. Nature. 2014 Apr 03; 508(7494):93-7. Zhu S, Rezvani M, Harbell J, Mattis AN, Wolfe AR, Benet LZ, Willenbring H, Ding S. PMID: 24572354; PMCID: PMC4161230.
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    84. Prevalence of acid-reducing agents (ARA) in cancer populations and ARA drug-drug interaction potential for molecular targeted agents in clinical development. Mol Pharm. 2013 Nov 04; 10(11):4055-62. Smelick GS, Heffron TP, Chu L, Dean B, West DA, Duvall SL, Lum BL, Budha N, Holden SN, Benet LZ, Frymoyer A, Dresser MJ, Ware JA. PMID: 24044612.
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    85. Effect of P-glycoprotein on the rat intestinal permeability and metabolism of the BDDCS class 1 drug verapamil. Mol Pharm. 2013 Nov 04; 10(11):4038-45. Estudante M, Maya M, Morais JG, Soveral G, Benet LZ. PMID: 24044638.
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    86. Changes in clearance, volume and bioavailability of immunosuppressants when given with HAART in HIV-1 infected liver and kidney transplant recipients. Biopharm Drug Dispos. 2013 Nov; 34(8):442-51. Frassetto L, Floren L, Barin B, Browne M, Wolfe A, Roland M, Stock P, Carlson L, Christians U, Benet L. PMID: 24030928; PMCID: PMC4018225.
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    87. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 04; 10(11):4032-7. Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. PMID: 23980906; PMCID: PMC3946491.
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    88. The nonenzymatic reactivity of the acyl-linked metabolites of mefenamic acid toward amino and thiol functional group bionucleophiles. Drug Metab Dispos. 2013 Nov; 41(11):1923-33. Horng H, Benet LZ. PMID: 23975029; PMCID: PMC3807055.
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    89. Characterization of the acyl-adenylate linked metabolite of mefenamic Acid. Chem Res Toxicol. 2013 Mar 18; 26(3):465-76. Horng H, Benet LZ. PMID: 23402341; PMCID: PMC3626286.
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    90. Pharmacokinetics and metabolism of 2-aminothiazoles with antiprion activity in mice. Pharm Res. 2013 Apr; 30(4):932-50. Silber BM, Rao S, Fife KL, Gallardo-Godoy A, Renslo AR, Dalvie DK, Giles K, Freyman Y, Elepano M, Gever JR, Li Z, Jacobson MP, Huang Y, Benet LZ, Prusiner SB. PMID: 23417511; PMCID: PMC3640342.
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    91. Drug discovery and regulatory considerations for improving in silico and in vitro predictions that use Caco-2 as a surrogate for human intestinal permeability measurements. AAPS J. 2013 Apr; 15(2):483-97. Larregieu CA, Benet LZ. PMID: 23344793; PMCID: PMC3675726.
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    92. The role of BCS (biopharmaceutics classification system) and BDDCS (biopharmaceutics drug disposition classification system) in drug development. J Pharm Sci. 2013 Jan; 102(1):34-42. Benet LZ. PMID: 23147500; PMCID: PMC3684558.
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    93. A step closer to personalized chemotherapy: consideration of the influence of genetic variation in hepatic uptake transporters on the metabolism of CYP3A substrates. Clin Pharmacol Ther. 2012 Nov; 92(5):551-2. Benet LZ. PMID: 23085879.
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    94. Intestinal drug transporters: an overview. Adv Drug Deliv Rev. 2013 Oct; 65(10):1340-56. Estudante M, Morais JG, Soveral G, Benet LZ. PMID: 23041352.
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    95. Drug absorption interactions between oral targeted anticancer agents and PPIs: is pH-dependent solubility the Achilles heel of targeted therapy? Clin Pharmacol Ther. 2012 Aug; 92(2):203-13. Budha NR, Frymoyer A, Smelick GS, Jin JY, Yago MR, Dresser MJ, Holden SN, Benet LZ, Ware JA. PMID: 22739140.
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    96. Benet L Z and Galeazzi R L: noncompartmental determination of the steady-state volume of distribution, J Pharm Sci 68, 1071-1074, 1979--the backstory. AAPS J. 2012 Jun; 14(2):164-7. Benet LZ. PMID: 22302585; PMCID: PMC3326156.
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    97. Sotalol permeability in cultured-cell, rat intestine, and PAMPA system. Pharm Res. 2012 Jul; 29(7):1768-74. Liu W, Okochi H, Benet LZ, Zhai SD. PMID: 22350803; PMCID: PMC4167886.
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    98. BDDCS class prediction for new molecular entities. Mol Pharm. 2012 Mar 05; 9(3):570-80. Broccatelli F, Cruciani G, Benet LZ, Oprea TI. PMID: 22224483; PMCID: PMC3295927.
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    99. Improving the prediction of the brain disposition for orally administered drugs using BDDCS. Adv Drug Deliv Rev. 2012 Jan; 64(1):95-109. Broccatelli F, Larregieu CA, Cruciani G, Oprea TI, Benet LZ. PMID: 22261306; PMCID: PMC3496430.
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    100. Impact of a hospitalwide increase in empiric pediatric vancomycin dosing on initial trough concentrations. Pharmacotherapy. 2011 Sep; 31(9):871-6. Frymoyer A, Guglielmo BJ, Wilson SD, Scarpace SB, Benet LZ, Hersh AL. PMID: 21923588; PMCID: PMC3727161.
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    101. Pharmacokinetic differences corroborate observed low tacrolimus dosage in Native American renal transplant patients. Drug Metab Dispos. 2011 Nov; 39(11):2017-9. Grover A, Frassetto LA, Benet LZ, Chakkera HA. PMID: 21849516; PMCID: PMC3198899.
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    102. BDDCS applied to over 900 drugs. AAPS J. 2011 Dec; 13(4):519-47. Benet LZ, Broccatelli F, Oprea TI. PMID: 21818695; PMCID: PMC3231854.
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    103. Lead PK commentary: predicting human pharmacokinetics. J Pharm Sci. 2011 Oct; 100(10):4047-9. Rowland M, Benet LZ. PMID: 21630278.
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    104. Professor Akira Tsuji: scientist, educator, and leader. J Pharm Sci. 2011 Sep; 100(9):3541-6. Terasaki T, Sugiyama Y, Benet LZ. PMID: 21630279.
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    105. Effects of uremic toxins on transport and metabolism of different biopharmaceutics drug disposition classification system xenobiotics. J Pharm Sci. 2011 Sep; 100(9):3831-42. Reyes M, Benet LZ. PMID: 21618544; PMCID: PMC3581075.
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    106. Intermittent drug dosing intervals guided by the operational multiple dosing half lives for predictable plasma accumulation and fluctuation. J Pharmacokinet Pharmacodyn. 2011 Jun; 38(3):369-83. Grover A, Benet LZ. PMID: 21499748; PMCID: PMC3677834.
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    107. The BCS, BDDCS, and regulatory guidances. Pharm Res. 2011 Jul; 28(7):1774-8. Chen ML, Amidon GL, Benet LZ, Lennernas H, Yu LX. PMID: 21491148.
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    108. Is Ciprofloxacin a Substrate of P-glycoprotein? Arch Drug Inf. 2011 Mar; 4(1):1-9. Park MS, Okochi H, Benet LZ. PMID: 21572514; PMCID: PMC3084506.
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    109. Founding figures of pharmacokinetics: tribute to Malcolm Rowland. J Pharmacokinet Pharmacodyn. 2010 Dec; 37(6):525-7. Aarons L, Benet LZ. PMID: 21069561.
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    110. Clearance (née Rowland) concepts: a downdate and an update. J Pharmacokinet Pharmacodyn. 2010 Dec; 37(6):529-39. Benet LZ. PMID: 21113650; PMCID: PMC3005114.
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    111. Age and sex differences in the effects of the immunosuppressants cyclosporine, sirolimus and everolimus on rat brain metabolism. Neurotoxicology. 2011 Jan; 32(1):50-7. Gottschalk S, Cummins CL, Leibfritz D, Christians U, Benet LZ, Serkova NJ. PMID: 21075140.
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    112. Effect of single-dose rifampin on the pharmacokinetics of warfarin in healthy volunteers. Clin Pharmacol Ther. 2010 Oct; 88(4):540-7. Frymoyer A, Shugarts S, Browne M, Wu AH, Frassetto L, Benet LZ. PMID: 20703222; PMCID: PMC3091944.
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    113. The FDA should eliminate the ambiguities in the current BCS biowaiver guidance and make public the drugs for which BCS biowaivers have been granted. Clin Pharmacol Ther. 2010 Sep; 88(3):405-7. Benet LZ, Larregieu CA. PMID: 20668447; PMCID: PMC4169211.
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    114. Prediction of vancomycin pharmacodynamics in children with invasive methicillin-resistant Staphylococcus aureus infections: a Monte Carlo simulation. Clin Ther. 2010 Mar; 32(3):534-42. Frymoyer A, Hersh AL, Coralic Z, Benet LZ, Joseph Guglielmo B. PMID: 20399990; PMCID: PMC3097025.
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    161. P-glycoprotein (P-gp/MDR1)-mediated efflux of sex-steroid hormones and modulation of P-gp expression in vitro. Pharm Res. 2004 Jul; 21(7):1284-93. Kim WY, Benet LZ. PMID: 15290871.
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    365. Effect of cimetidine or ranitidine administration on nifedipine pharmacokinetics and pharmacodynamics. Clin Pharmacol Ther. 1988 Jun; 43(6):673-80. Schwartz JB, Upton RA, Lin ET, Williams RL, Benet LZ. PMID: 3378388.
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    366. Simultaneous determination of nitroglycerin and its dinitrate metabolites by capillary gas chromatography with electron-capture detection. J Chromatogr. 1988 Apr 29; 426(2):259-66. Lee FW, Watari N, Rigod J, Benet LZ. PMID: 3134385.
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    373. Pharmacokinetics and excretion of unique beta-adrenergic agonists. Pharmacology. 1987; 34(2-3):157-66. Ferraiolo BL, Halldin MM, Asscher Y, Akita Y, Melmon KL, Benet LZ, Castagnoli N. PMID: 2884679.
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    406. Unchanged absorption of digoxin tablets in patients with cardiac failure. Pharmacology. 1984; 28(2):90-4. Meister W, Benowitz NL, Benet LZ. PMID: 6709691.
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    420. Specific and sensitive assay of celiprolol in blood, plasma and urine using high-performance liquid chromatography. J Chromatogr. 1982 Jul 09; 230(2):454-60. Buskin JN, Upton RA, Sörgel F, Williams RL, Lang E, Benet LZ. PMID: 6213630.
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    428. Membrane populations of bovine choroid plexus: separation by density gradient centrifugation in modified colloidal silica. J Neurochem. 1981 Sep; 37(3):768-74. Mamelok RD, Macrae DR, Benet LZ, Prusiner SB. PMID: 6115891.
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    455. Pharmacokinetics/pharmacodynamics of furosemide in man: a review. J Pharmacokinet Biopharm. 1979 Feb; 7(1):1-27. Benet LZ. PMID: 458552.
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    456. Pseudoephedrine pharmacokinetics in the rat using a microanalysis technique. Pharmacology. 1979; 18(6):306-10. Till AE, Benet LZ. PMID: 493335.
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    457. Relationship between urinary excretion rate, steady-state plasma levels and diuretic response of furosemide in the rat. Pharmacology. 1979; 19(6):301-6. Smith DE, Benet LZ. PMID: 549032.
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    458. Pharmacokinetics of furosemide in patients with congestive heart failure. Pharmacology. 1979; 19(3):121-31. Greither A, Goldman S, Edelen JS, Benet LZ, Cohn K. PMID: 523503.
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    460. Pharmacokinetics and pharmacodynamics of d-tubocurarine during hypothermia in the cat. Anesthesiology. 1978 Nov; 49(5):324-9. Ham J, Miller RD, Benet LZ, Matteo RS, Roderick LL. PMID: 736287.
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    462. Pharmacokinetics of cefamandole using a HPLC assay. J Pharmacokinet Biopharm. 1978 Apr; 6(2):153-64. Aziz NS, Gambertoglio JG, Lin ET, Grausz H, Benet LZ. PMID: 671221.
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    463. Acute massive chloral hydrate intoxication treated with hemodialysis: a clinical pharmacokinetic analysis. J Clin Pharmacol. 1978 Feb-Mar; 18(2-3):136-42. Stalker NE, Gambertoglio JG, Fukumitsu CJ, Naughton JL, Benet LZ. PMID: 624775.
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    464. Ascorbate stimulation of salicylate absorption in isolated rat intestine. J Pharm Sci. 1978 Feb; 67(2):224-6. Barnett G, Lockwood T, Arancibia A, Benet LZ. PMID: 621642.
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    465. The reversible biotransformation of N-acetylprocainamide in the rhesus monkey. Arzneimittelforschung. 1978; 28(2):281-3. Ding TL, Lin ET, Benet LZ. PMID: 416831.
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    467. Gas-liquid chromatographic determination of pseudoephedrine and norpseudoephedrine in human plasma and urine. J Chromatogr. 1977 Oct 21; 140(3):275-9. Lin ET, Brater DC, Benet LZ. PMID: 914918.
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    471. Relationship between the pharmacokinetics and pharmacodynamics of procainamide. Clin Pharmacol Ther. 1976 Sep; 20(3):278-89. Galeazzi RL, Benet LZ, Sheiner LB. PMID: 954350.
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    472. Inappropriate use of the law of corresponding areas to calculate the time course of absorption for multicompartmental systems. J Pharmacokinet Biopharm. 1976 Feb; 4(1):43-56. Galeazzi RL, Benet LZ. PMID: 1271239.
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    473. Limitations in interpretation of digoxin adsorption using averaged pharmacological response intensities. J Pharm Sci. 1976 Feb; 65(2):243-7. Gustafson JH, Schoenwald RD, Benet LZ. PMID: 1255456.
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    476. Biliary excretion kinetics of phenolphthalein glucuronide after intravenous and retrograde biliary administration. J Pharm Pharmacol. 1974 Dec; 26(12):937-44. Gustafson JH, Benet LZ. PMID: 4156858.
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    479. Clearance concepts in pharmacokinetics. J Pharmacokinet Biopharm. 1973 Apr; 1(2):123-36. Rowland M, Benet LZ, Graham GG. PMID: 4764426.
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    481. Gastrointestinal absorption of iopanoic acid. Invest Radiol. 1973 Jan-Feb; 8(1):1-8. Nelson JA, Moss AA, Goldberg HI, Benet LZ, Amberg J. PMID: 4685376.
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    482. General treatment of linear mammillary models with elimination from any compartment as used in pharmacokinetics. J Pharm Sci. 1972 Apr; 61(4):536-41. Benet LZ. PMID: 5014309.
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    483. Use of general partial fraction theorem for obtaining inverse laplace transforms in pharmacokinetic analysis. J Pharm Sci. 1971 Oct; 60(10):1593-4. Benet LZ, Turi JS. PMID: 5129385.
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    484. Drug transfer across rat intestinal musculature after edetic acid treatment. J Pharm Sci. 1971 Oct; 60(10):1508-11. Nayak RK, Benet LZ. PMID: 5001965.
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    486. Apparent directional permeability coefficients for drug ions: in vitro intestinal perfusion studies. J Pharm Sci. 1970 May; 59(5):590-5. Turner RH, Mehta CS, Benet LZ. PMID: 5446410.
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    487. Two-compartment model for a drug and its metabolite: application to acetylsalicylic acid pharmacokinetics. J Pharm Sci. 1970 Mar; 59(3):364-7. Rowland M, Benet LZ, Riegelman S. PMID: 5416180.
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    488. Volume terms in pharmacokinetics. J Pharm Sci. 1969 May; 58(5):639-41. Benet LZ, Ronfeld RA. PMID: 5796463.
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    489. Potentiometric determination of dissociation constants. J Pharm Sci. 1967 Jun; 56(6):665-80. Benet LZ, Goyan JE. PMID: 5340617.
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    490. Thermodynamics of chelation by tetracyclines. J Pharm Sci. 1966 Nov; 55(11):1184-90. Benet LZ, Goyan JE. PMID: 4961420.
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    491. Effect of inert tablet ingredients on drug absorption. I. Effect of polyethylene glycol 4000 on the intestinal absorption of four barbiturates. J Pharm Sci. 1966 Jan; 55(1):63-8. Singh P, Guillory JK, Sokoloski TD, Benet LZ, Bhatia VN. PMID: 5918653.
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    492. Nonlogarithmic titration curves for the determination of dissociation constants and purity. J Pharm Sci. 1965 Aug; 54(8):1179-82. Benet LZ, Goyan JE. PMID: 4956613.
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    493. Determination of the stability constants of tetracycline complexes. J Pharm Sci. 1965 Jul; 54(7):983-7. Benet LZ, Goyan JE. PMID: 5862536.
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