Alan Baik, MD

Title(s)Assistant Professor, Medicine
SchoolSchool of Medicine
Address555 Mission Bay Blvd South, #382
San Francisco CA 94158
Phone415-476-1528
ORCID ORCID Icon0000-0001-8840-8825 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Harvard College, Cambridge, MA AB05/2008Biology
    University of California, San Francisco, San Francisco, CAMD06/2014Medicine
    University of California, San Francisco, San Francisco, CA06/2017Internal Medicine
    University of California, San Francisco, San Francisco, CA 06/2021Cardiovascular Medicine
    Collapse Awards and Honors
    2024American Heart Association-Harold Amos Medical Faculty Development Program
    2023Distinguished Achievement in Science Award, Gladstone Institutes
    2021  - 2023Sarnoff Scholar Career Development Award
    2021  - 2023Chan-Zuckerberg Biohub Physician-Scientist Fellow
    2019  - 2021T32 NIH Institutional Training Grant
    2014UCSF Dean's Award in Molecular Medicine
    2012  - 2013Sarnoff Cardiovascular Research Fellowship (2nd Year Fellow)
    2011  - 2012Sarnoff Cardiovascular Research Fellowship (1st Year Fellow)

    Collapse Overview 
    Collapse Overview
    I am a cardiologist with an expertise in cardio-oncology. Cardio-oncology is an emerging field in cardiovascular medicine that is focused on the cardiovascular care of cancer patients and survivors who have developed cardiovascular disease from their cancer-directed therapies. These therapies include traditional chemotherapy, immunotherapy, targeted therapy, and radiation therapy, among others. Cancer patients are at increased risk of cardiovascular disease, and this can be further exacerbated by their cancer-directed therapies, which can cause a myriad of cardiovascular problems, such as cardiomyopathy, heart failure, arrhythmias, hypertension, pericardial disease, valvular disease, and metabolic syndrome. I work closely with oncologists and other providers in a multidisciplinary team to optimize the cardiovascular care of cancer patients.

    I am also a physician-scientist with a research focus on how cells, tissues, and organisms respond and adapt to low oxygen (hypoxia) and high oxygen (hyperoxia) states. I am studying novel ways cells and tissues respond to states of low oxygen and why high oxygen is toxic at the cellular and systemic levels.

    Collapse Research 
    Collapse Research Activities and Funding
    SREBP1 as a Novel Mammalian Oxygen Sensor
    NIH K08 1K08HL169915Apr 1, 2024 - Mar 31, 2029
    Role: PI

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Acute radiation-induced pericarditis complicated by polymicrobial infectious pericarditis in a patient with mediastinal sarcoma: a case report. Eur Heart J Case Rep. 2024 Feb; 8(2):ytae084. Yan KL, Lee YJ, Baik AH. PMID: 38405193; PMCID: PMC10894000.
      View in: PubMed   Mentions:
    2. Left atrial strain is reduced following trastuzumab in breast cancer patients. Echocardiography. 2024 Jan; 41(1):e15751. Lassen MCH, Arya F, Biering-Sørensen T, Reeh JLT, Melisko ME, Sarwary S, Baik AH, Aras MA, Qasim A. PMID: 38284677.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. In vivo protein turnover rates in varying oxygen tensions nominate MYBBP1A as a mediator of the hyperoxia response. Sci Adv. 2023 Dec 08; 9(49):eadj4884. Chen X, Haribowo AG, Baik AH, Fossati A, Stevenson E, Chen YR, Reyes NS, Peng T, Matthay MA, Traglia M, Pico AR, Jarosz DF, Buchwalter A, Ghaemmaghami S, Swaney DL, Jain IH. PMID: 38064566; PMCID: PMC10708181.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    4. Osimertinib-induced biventricular cardiomyopathy with abnormal cardiac MRI findings: a case report. Cardiooncology. 2023 Oct 31; 9(1):38. Patel K, Hsu KY, Lou K, Soni K, Lee YJ, Mulvey CK, Baik AH. PMID: 37908018; PMCID: PMC10617075.
      View in: PubMed   Mentions: 1  
    5. Equity in Cardio-Oncology Care and Research: A Scientific Statement From the American Heart Association. Circulation. 2023 07 18; 148(3):297-308. Addison D, Branch M, Baik AH, Fradley MG, Okwuosa T, Reding KW, Simpson KE, Suero-Abreu GA, Yang EH, Yancy CW, American Heart Association Cardio-Oncology Committee of the Council on Clinical Cardiology and Counc. PMID: 37377045.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    6. Oxygen toxicity causes cyclic damage by destabilizing specific Fe-S cluster-containing protein complexes. Mol Cell. 2023 03 16; 83(6):942-960.e9. Baik AH, Haribowo AG, Chen X, Queliconi BB, Barrios AM, Garg A, Maishan M, Campos AR, Matthay MA, Jain IH. PMID: 36893757; PMCID: PMC10148707.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    7. Editorial commentary: Immune checkpoint inhibitors and the cardiovascular system: Reflecting on the past and looking towards the future. Trends Cardiovasc Med. 2024 02; 34(2):78-79. Baik AH. PMID: 36309121.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Hypoxia signaling and oxygen metabolism in cardio-oncology. J Mol Cell Cardiol. 2022 04; 165:64-75. Baik AH. PMID: 34979102.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    9. Clinical Strategy for the Diagnosis and Treatment of Immune Checkpoint Inhibitor-Associated Myocarditis: A Narrative Review. JAMA Cardiol. 2021 11 01; 6(11):1329-1337. Lehmann LH, Cautela J, Palaskas N, Baik AH, Meijers WC, Allenbach Y, Alexandre J, Rassaf T, Müller OJ, Aras M, Asnani AH, Deswal A, Laufer-Perl M, Thuny F, Kerneis M, Hayek SS, Ederhy S, Salem JE, Moslehi JJ. PMID: 34232253.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    10. Mechanisms of Cardiovascular Toxicities Associated With Immunotherapies. Circ Res. 2021 05 28; 128(11):1780-1801. Baik AH, Oluwole OO, Johnson DB, Shah N, Salem JE, Tsai KK, Moslehi JJ. PMID: 33934609; PMCID: PMC8159878.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    11. Preclinical Models of Cancer Therapy-Associated Cardiovascular Toxicity: A Scientific Statement From the American Heart Association. Circ Res. 2021 06 25; 129(1):e21-e34. Asnani A, Moslehi JJ, Adhikari BB, Baik AH, Beyer AM, de Boer RA, Ghigo A, Grumbach IM, Jain S, Zhu H, American Heart Association Council on Basic Cardiovascular Sciences; Cardio-Oncology Science Subcomm. PMID: 33934611; PMCID: PMC8423100.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    12. Mechanisms and clinical manifestations of cardiovascular toxicities associated with immune checkpoint inhibitors. Clin Sci (Lond). 2021 03 12; 135(5):703-724. Baik AH, Tsai KK, Oh DY, Aras MA. PMID: 33686402; PMCID: PMC8647663.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    13. Abstract 14843: Electrocardiographic Manifestations of Immune Checkpoint Inhibitor Associated Myocarditis. Circulation. 2020 Nov 17; 142(Suppl_3). Power PJ, Alexandre AJ, Choudhary CA, ozbay ob, Palaskas PN, Lehmann LL, Finke FD, Cautela CJ, Thuny TF, Tamura TY, Hayek HS, Azam AT, Asnani AA, Mehegan MT, Aras AM, Baik BA, Gilstrap GL, Laufer-Perl LM, Arangalage AD, Ewer ES, Martini MM, Nowatzke NJ, Orimoloye OO, Brinkley BD, Meijers MW, Fenioux FC, EDERHY ES, Moslehi MJ, Salem SJ. .
      View in: Publisher Site   Mentions:
    14. Abstract 15365: Natural History of Immune Checkpoint Inhibitor Associated Myocarditis With Preserved Ejection Fraction. Circulation. 2020 Nov 17; 142(Suppl_3). Nowatzke NJ, Power PJ, Meijers MW, Orimoloye OO, Fenioux FC, Tamura TY, Cautela CJ, Lehmann LL, Finke FD, Hayek HS, Azam AT, Asnani AA, Mehegan MT, Weppler WA, Baik BA, Aras AM, Narezkina NA, Arangalage AD, rocher rf, Alexandre AG, Palaskas PN, Salem SJ, Moslehi MJ. .
      View in: Publisher Site   Mentions:
    15. Turning the Oxygen Dial: Balancing the Highs and Lows. Trends Cell Biol. 2020 07; 30(7):516-536. Baik AH, Jain IH. PMID: 32386878; PMCID: PMC7391449.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    16. EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection. Cell. 2016 Apr 07; 165(2):497. Olenchock BA, Moslehi J, Baik AH, Davidson SM, Williams J, Gibson WJ, Chakraborty AA, Pierce KA, Miller CM, Hanse EA, Kelekar A, Sullivan LB, Wagers AJ, Clish CB, Vander Heiden MG, Kaelin WG. PMID: 27058668.
      View in: PubMed   Mentions: 15     Fields:    
    17. EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection. Cell. 2016 Feb 25; 164(5):884-95. Olenchock BA, Moslehi J, Baik AH, Davidson SM, Williams J, Gibson WJ, Chakraborty AA, Pierce KA, Miller CM, Hanse EA, Kelekar A, Sullivan LB, Wagers AJ, Clish CB, Vander Heiden MG, Kaelin WG. PMID: 26919427; PMCID: PMC4819986.
      View in: PubMed   Mentions: 59     Fields:    Translation:Animals
    18. ACUTE HYPOXIA-INDUCIBLE FACTOR EGLN1 INACTIVATION PROTECTS AGAINST ISCHEMIA-REPERFUSION INJURY BY REGULATION OF GLUCOSE OXIDATION AND REACTIVE OXYGEN SPECIES GENERATION. Journal of the American College of Cardiology. 2013 Mar 1; 61(10):e28. Baik BA, Olenchock OB, Moslehi MJ, Kaelin KW. .
      View in: Publisher Site   Mentions:
    19. Genetic subdivision of chemosynthetic endosymbionts of Solemya velum along the Southern New England coast. Appl Environ Microbiol. 2009 Sep; 75(18):6005-7. Stewart FJ, Baik AH, Cavanaugh CM. PMID: 19633116; PMCID: PMC2747846.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
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