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Alden Harken, MD

Address1411 East 31st Street
Oakland CA 94602
Phone510-437-4091
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    Collapse Research 
    Collapse Research Activities and Funding
    Overall Application: Trauma Primes Cells
    NIH/NIGMS P50GM049222Apr 1, 1993 - May 31, 2016
    Role: Co-Principal Investigator
    Overall Application: Trauma Primes Cells
    NIH/NIGMS P50GM049222Apr 1, 1993 - May 31, 2016
    Role: Co-Principal Investigator
    Overall Application: Trauma Primes Cells
    NIH/NIGMS P50GM049222Apr 1, 1993 - May 31, 2016
    Role: Co-Principal Investigator
    Mechanisms of Post-Injury Organ Failure
    NIH/NIGMS T32GM008315Jul 1, 1991 - Jun 30, 2021
    Role: Co-Principal Investigator
    Mechanisms of Post-Injury Organ Failure
    NIH/NIGMS T32GM008315Jul 1, 1991 - Jun 30, 2021
    Role: Co-Principal Investigator
    Mechanisms of Post-Injury Organ Failure
    NIH/NIGMS T32GM008315Jul 1, 1991 - Jun 30, 2021
    Role: Co-Principal Investigator
    CYTOKINE ENHANCEMENT OF POSTISCHEMIC CARDIAC FUNCTION
    NIH/NHLBI R01HL044186Jan 1, 1990 - Dec 31, 1994
    Role: Principal Investigator
    CYTOKINE ENHANCEMENT OF POSTISCHEMIC CARDIAC FUNCTION
    NIH/NHLBI R01HL044186Jan 1, 1990 - Dec 31, 1994
    Role: Principal Investigator
    CYTOKINE ENHANCEMENT OF POSTISCHEMIC CARDIAC FUNCTION
    NIH/NHLBI R01HL044186Jan 1, 1990 - Dec 31, 1994
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Selected Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Harken AH. Macro or micro: The beat goes on. J Thorac Cardiovasc Surg. 2016 Sep; 152(3):932. PMID: 27318617.
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    2. Harken AH. Aortic dissection and DNA repair. J Thorac Cardiovasc Surg. 2015 Nov; 150(5):1301-2. PMID: 26395046.
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    3. Chong V, Imhoff L, Harken A. Socioeconomic status and the assessment of operative risk. Surgery. 2015 Apr; 157(4):605-8. PMID: 25633737.
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    4. Harken AH. To block or not to block? That is the question. J Thorac Cardiovasc Surg. 2015 Apr; 149(4):1040-1. PMID: 25659853.
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    5. Harken AH. Heart and soul. J Thorac Cardiovasc Surg. 2014 Nov; 148(5):2380. PMID: 25444201.
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    6. Harken AH. How much do we really know about statins and transplant vasculopathy? World J Surg. 2014 Sep; 38(9):2335-6. PMID: 24844656.
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    7. Green A, Markham S, Williams J, Graf J, Morgan A, Brooke M, Harken AH. The ladies need more attention. Surgery. 2014 Sep; 156(3):517-8. PMID: 25175502.
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    8. Upadhyaya P, Smith R, Swift UM, Warshaw AL, Harken AH. Mentoring for global health missions. Surgery. 2013 Jun; 153(6):866-70. PMID: 23489941.
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    9. Harken AH. Joseph Murray as mentor. J Craniofac Surg. 2013 Jan; 24(1):38-40. PMID: 23321868.
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    10. Palmer BJ, Parks NS, Harken AH. Surgical trainees like to be trained. Surgery. 2012 Nov; 152(5):805-6. PMID: 23084409.
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    11. Yeung L, Miraflor E, Harken A. Confronting the chronically anticoagulated, acute care surgery patient as we evolve into the post-warfarin era. Surgery. 2013 Mar; 153(3):308-15. PMID: 23122931.
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    12. Zaydfudim V, Sarr MG, Harken AH, Warshaw AL. Tumor vs neoplasm: it is not just semantics. Surgery. 2013 Apr; 153(4):603-4. PMID: 22910489.
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    13. Lin C, Sasaki T, Strumwasser A, Harken A. The case against BRCA 1 and 2 testing. Surgery. 2011 Jun; 149(6):731-4. PMID: 21621683.
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    14. Harken T, Harken A. Pregnancy is protective. Surgery. 2011 Feb; 149(2):163. PMID: 21238711.
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    15. Harken AH. Edgar J. Poth memorial lecture: the future of general surgery is controlled by surgical megafauna. Am J Surg. 2010 Dec; 200(6):678-80. PMID: 21146001.
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    16. Restivo TE, Mace KA, Harken AH, Young DM. Application of the chemokine CXCL12 expression plasmid restores wound healing to near normal in a diabetic mouse model. J Trauma. 2010 Aug; 69(2):392-8. PMID: 20699749.
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    17. Harken TR, Russell KW, Harken A, Russell RT. Surgical megafauna. Bull Am Coll Surg. 2010 Mar; 95(3):24-8. PMID: 21456404.
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    18. Bullard MK, Bir N, Kwan R, Cureton E, Knudson P, Harken A. Women rule. Surgery. 2010 Jan; 147(1):134-7. PMID: 20082798.
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    19. Wielgus J, Sarr MG, Warshaw AL, Harken AH. Words, words, words. Surgery. 2010 Jan; 147(1):138-9. PMID: 20082799.
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    20. Cureton EL, Ereso AQ, Victorino GP, Curran B, Poole DP, Liao M, Harken AH, Bhargava A. Local secretion of urocortin 1 promotes microvascular permeability during lipopolysaccharide-induced inflammation. Endocrinology. 2009 Dec; 150(12):5428-37. PMID: 19819946; PMCID: PMC2795720.
    21. Francis-Goforth KN, Harken AH, Saba JD. Normalization of diabetic wound healing. Surgery. 2010 Mar; 147(3):446-9. PMID: 19703697; PMCID: PMC2827630.
    22. Palmer BJ, Stams V, Russell TR, Harken AH, Britt LD. ACS promotes the six competencies of the accreditation council for graduate medical education. Bull Am Coll Surg. 2009 Jul; 94(7):16-22. PMID: 19718967.
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    23. Harken AH. Commentary: Kubler-Ross 5 stages in the recognition of poor surgical resident performance. Surgery. 2009 Jun; 145(6):661-2. PMID: 19486770.
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    24. Cripps MW, Ereso AQ, Sadjadi J, Harken AH, Victorino GP. The number of gunshot wounds does not predict injury severity and mortality. Am Surg. 2009 Jan; 75(1):44-7; discussion 48. PMID: 19213396.
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    25. Williams TM, Sadjadi J, Harken AH, Victorino GP. The necessity to assess anticoagulation status in elderly injured patients. J Trauma. 2008 Oct; 65(4):772-6; discussion 776-7. PMID: 18849789.
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    26. Liu T, Harken AH. Surgical education is safe. J Card Surg. 2008 Jan-Feb; 23(1):6-7. PMID: 18290879.
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    27. Williams TM, Harken AH. Statins for surgical patients. Ann Surg. 2008 Jan; 247(1):30-7. PMID: 18156920.
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    28. Baldwin ZK, Spitzer AL, Ng VL, Harken AH. Contemporary standards for the diagnosis and treatment of heparin-induced thrombocytopenia (HIT). Surgery. 2008 Mar; 143(3):305-12. PMID: 18291250.
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    29. Backster A, Teo A, Swift M, Polk HC, Harken AH. Transforming the surgical "time-out" into a comprehensive "preparatory pause". J Card Surg. 2007 Sep-Oct; 22(5):410-6. PMID: 17803578.
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    30. Kumar AS, Shibru D, Bullard MK, Liu T, Harken AH. Case-based multimedia program enhances the maturation of surgical residents regarding the concepts of professionalism. J Surg Educ. 2007 Jul-Aug; 64(4):194-8. PMID: 17706570.
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    31. Roland CL, Harken AH, Sarr MG, Barnett CC. ICAM-1 expression determines malignant potential of cancer. Surgery. 2007 Jun; 141(6):705-7. PMID: 17560245.
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    32. Altpeter T, Luckhardt K, Lewis JN, Harken AH, Polk HC. Expanded surgical time out: a key to real-time data collection and quality improvement. J Am Coll Surg. 2007 Apr; 204(4):527-32. PMID: 17382210.
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    33. Harken AH. Surgical research promotes world peace. Ann Surg. 2007 Apr; 245(4):524-5. PMID: 17414598; PMCID: PMC1877046.
    34. Pavlic LK, Harken AH, Sethna D. Transvenous cardioverter-defibrillator placement via a persistent left superior vena cava. J Card Surg. 2007 Mar-Apr; 22(2):152-3. PMID: 17338754.
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    35. Bullard MK, Swift M, Harken A. Genomics and the cardiac surgeon. J Card Surg. 2007 Jan-Feb; 22(1):83-6. PMID: 17239225.
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    36. Tendulkar AP, Harken AH. Mechanics of the normal heart. J Card Surg. 2006 Nov-Dec; 21(6):615-20. PMID: 17073971.
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    37. Swift UM, Harken AH. Da Vinci's problem. Surgery. 2006 Sep; 140(3):336-7. PMID: 16934590.
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    38. Wan JJ, Mortensen E, Knudson MM, Harken AH. Blood doping in the surgical intensive care unit. Surgery. 2006 Jul; 140(1):6-8. PMID: 16857435.
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    39. Harken AH. Brain death leads to abnormal contractile properties of the human donor right ventricle. J Thorac Cardiovasc Surg. 2006 Jul; 132(1):10-1. PMID: 16798295.
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    40. McGee GE, Warshaw AL, Harken AH. Mississippi medical liability reform experience. Surgery. 2006 Apr; 139(4):462-5. PMID: 16627054.
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    41. Swift MB, Altman D, Allison G, Iton A, Kears D, Rose T, Harken AH. Osler's advice to "shun politics" is outdated. Surgery. 2006 Apr; 139(4):466-8. PMID: 16627055.
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    42. Pal JD, Victorino GP, Twomey P, Liu TH, Bullard MK, Harken AH. Admission serum lactate levels do not predict mortality in the acutely injured patient. J Trauma. 2006 Mar; 60(3):583-7; discussion 587-9. PMID: 16531858.
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    43. Moore EE, Moore FA, Harken AH, Johnson JL, Ciesla D, Banerjee A. The two-event construct of postinjury multiple organ failure. Shock. 2005 Dec; 24 Suppl 1:71-4. PMID: 16374376.
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    44. Clarke JH, Cha JY, Walsh MD, Harken AH, McCarter MD. Dendritic cells as therapeutic adjuncts in surgical disease. Surgery. 2005 Nov; 138(5):844-50. PMID: 16291384.
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    45. Tendulkar AP, Victorino GP, Chong TJ, Bullard MK, Liu TH, Harken AH. Quantification of surgical resident stress "on call". J Am Coll Surg. 2005 Oct; 201(4):560-4. PMID: 16183494.
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    46. Harken AH. Hyperbolic hypotheses. Surgery. 2005 Sep; 138(3):404. PMID: 16213886.
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    47. Clarke JH, Cha JY, Walsh MD, Gamboni-Robertson F, Banerjee A, Reznikov LL, Dinarello CA, Harken AH, McCarter MD. Melanoma inhibits macrophage activation by suppressing toll-like receptor 4 signaling. J Am Coll Surg. 2005 Sep; 201(3):418-25. PMID: 16125076.
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    48. Sahar DE, Yang GP, Longaker MT, Harken AH. Surgical application of cDNA microarray technique. Surgery. 2005 Sep; 138(3):399-403. PMID: 16213884.
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    49. Ganim RB, Harken AH. Invited commentary: Looking beyond bare survival. Surgery. 2005 Feb; 137(2):178-9. PMID: 15674198.
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    50. Neidlinger NA, Hirvela ER, Skinner RA, Larkin SK, Harken AH, Kuypers FA. Postinjury serum secretory phospholipase A2 correlates with hypoxemia and clinical status at 72 hours. J Am Coll Surg. 2005 Feb; 200(2):173-8. PMID: 15664090.
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    51. Barry L, Blair PG, Cosgrove EM, Cruess RL, Cruess SR, Eastman AB, Fabri PJ, Kirksey TD, Liscum KR, Morrison R, Sachdeva AK, Svahn DS, Russell TR, Dickey J, Ungerleider RM, Harken AH. One year, and counting, after publication of our ACS "Code of Professional Conduct". J Am Coll Surg. 2004 Nov; 199(5):736-40. PMID: 15501114.
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    52. Raeburn CD, Zimmerman MA, Banerjee A, Cleveland CJ, Harken AH. Surgical applications of organ preconditioning. Minerva Chir. 2004 Jun; 59(3):209-18. PMID: 15252386.
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    53. Harken AH. Skateboards promote world peace. Surgery. 2004 May; 135(5):471-2. PMID: 15118581.
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    54. Barsness KA, Arcaroli J, Harken AH, Abraham E, Banerjee A, Reznikov L, McIntyre RC. Hemorrhage-induced acute lung injury is TLR-4 dependent. Am J Physiol Regul Integr Comp Physiol. 2004 Sep; 287(3):R592-9. PMID: 15072965.
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    55. McCarter MD, Clarke JH, Harken AH. Lymphangiogenesis is pivotal to the trials of a successful cancer metastasis. Surgery. 2004 Feb; 135(2):121-4. PMID: 14739845.
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    56. Arya J, Cha JY, Banerjee A, Harken AH. RNA silencing in surgical disease. Arch Surg. 2003 Oct; 138(10):1145-7; discussion 1148. PMID: 14557135.
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    57. Gruen RL, Arya J, Cosgrove EM, Cruess RL, Cruess SR, Eastman AB, Fabri PJ, Friedman P, Kirksey TD, Kodner IJ, Lewis FR, Liscum KR, Organ CH, Rosenfeld JC, Russell TR, Sachdeva AK, Zook EG, Harken AH. Professionalism in surgery. J Am Coll Surg. 2003 Oct; 197(4):605-8. PMID: 14522330.
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    58. Lyons WS, Calkins CM, Moore EE, Bensard DD, Partrick DA, McIntyre RC, Harken AH. "Resistance" to the inflammatory response and multiple organ failure in children. J Trauma. 2003 Jul; 55(1):182-4; author reply 183-4. PMID: 12855904.
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    59. Meldrum DR, Partrick DA, Cleveland JC, Shenkar R, Meldrum KK, Raiesdana A, Ayala A, Brown JW, Harken AH. On-pump coronary artery bypass surgery activates human myocardial NF-kappaB and increases TNF-alpha in the heart. J Surg Res. 2003 Jun 15; 112(2):175-9. PMID: 12888335.
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    60. Zimmerman MA, Selzman CH, Cothren C, Sorensen AC, Raeburn CD, Harken AH. Diagnostic implications of C-reactive protein. Arch Surg. 2003 Feb; 138(2):220-4. PMID: 12578424.
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    61. Calkins CM, Bensard DD, Moore EE, McIntyre RC, Silliman CC, Biffl W, Harken AH, Partrick DA, Offner PJ. The injured child is resistant to multiple organ failure: a different inflammatory response? J Trauma. 2002 Dec; 53(6):1058-63. PMID: 12478028.
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    62. Raeburn CD, Zimmerman MA, Arya J, Banerjee A, Harken AH. Stem cells and myocardial repair. J Am Coll Surg. 2002 Nov; 195(5):686-93. PMID: 12437260.
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    63. Harken AH. Invited commentary: how do we recruit bright and selflessly capable students into the gratifying profession of surgery? Surgery. 2002 Nov; 132(5):803-4. PMID: 12464863.
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    64. Raeburn CD, Zimmerman MA, Arya J, Barsness K, Harken AH. Ischemic preconditioning: fact or fantasy? J Card Surg. 2002 Nov-Dec; 17(6):536-42. PMID: 12643465.
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    65. Sheppard oR, Moore EE, Ryder J, Harken AH, Rezende-Neto JB, Banerjee A, Silliman CC. "Primed" human neutrophils on a standard peripheral blood smear. J Am Coll Surg. 2002 Nov; 195(5):731. PMID: 12437265.
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    66. Arya J, Wolford H, Harken AH. Evidence-based science: a worthwhile mode of surgical inquiry. Arch Surg. 2002 Nov; 137(11):1301-3. PMID: 12413324.
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    67. Zimmerman MA, Selzman CH, Reznikov LL, Miller SA, Raeburn CD, Emmick J, Meng X, Harken AH. Lack of TNF-alpha attenuates intimal hyperplasia after mouse carotid artery injury. Am J Physiol Regul Integr Comp Physiol. 2002 Aug; 283(2):R505-12. PMID: 12121864.
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    68. Raeburn CD, Calkins CM, Zimmerman MA, Song Y, Ao L, Banerjee A, Harken AH, Meng X. ICAM-1 and VCAM-1 mediate endotoxemic myocardial dysfunction independent of neutrophil accumulation. Am J Physiol Regul Integr Comp Physiol. 2002 Aug; 283(2):R477-86. PMID: 12121861.
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    69. Selzman CH, Miller SA, Zimmerman MA, Gamboni-Robertson F, Harken AH, Banerjee A. Monocyte chemotactic protein-1 directly induces human vascular smooth muscle proliferation. Am J Physiol Heart Circ Physiol. 2002 Oct; 283(4):H1455-61. PMID: 12234797.
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    70. Meng X, Harken AH. The interaction between Hsp70 and TNF-alpha expression: a novel mechanism for protection of the myocardium against post-injury depression. Shock. 2002 May; 17(5):345-53. PMID: 12022752.
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    71. Raeburn CD, Calkins CM, Zimmerman MA, Arya J, Barsness KA, Harken AH. Toll-like receptors and surgical disease. Surgery. 2002 May; 131(5):477-83. PMID: 12019398.
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    72. Rabaglia JL, Gonzalez R, Moore EE, Harken AH. Pooled human albumin primes neutrophils. J Card Surg. 2002 May-Jun; 17(3):209-13. PMID: 12489905.
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    73. Selzman CH, Turner AS, Gaynor JS, Miller SA, Monnet E, Harken AH. Inhibition of intimal hyperplasia using the selective estrogen receptor modulator raloxifene. Arch Surg. 2002 Mar; 137(3):333-6. PMID: 11888462.
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    74. Raeburn CD, Sheppard F, Barsness KA, Arya J, Harken AH. Cytokines for surgeons. Am J Surg. 2002 Mar; 183(3):268-73. PMID: 11943124.
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    75. Meldrum KK, Meldrum DR, Meng X, Ao L, Harken AH. TNF-alpha-dependent bilateral renal injury is induced by unilateral renal ischemia-reperfusion. Am J Physiol Heart Circ Physiol. 2002 Feb; 282(2):H540-6. PMID: 11788401.
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    76. Cothren C, Ferucci P, Harken AH, Veve R, Finlayson CA, Johnson JL. Urachal carcinoma: key points for the general surgeon. Am Surg. 2002 Feb; 68(2):201-3. PMID: 11842971.
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    77. Shames BD, Barton HH, Reznikov LL, Cairns CB, Banerjee A, Harken AH, Meng X. Ischemia alone is sufficient to induce TNF-alpha mRNA and peptide in the myocardium. Shock. 2002 Feb; 17(2):114-9. PMID: 11837786.
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    78. Meng X, Ao L, Shames BD, Harken AH. Inhibition of cyclic-3',5'-nucleotide phosphodiesterase abrogates the synergism of hypoxia with lipopolysaccharide in the induction of macrophage TNF-alpha production. J Surg Res. 2001 Dec; 101(2):210-5. PMID: 11735278.
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    79. Raeburn CD, Cleveland JC, Zimmerman MA, Harken AH. Organ preconditioning. Arch Surg. 2001 Nov; 136(11):1263-6. PMID: 11695970.
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    80. Zimmerman MA, Selzman CH, Raeburn CD, Calkins CM, Barsness K, Harken AH. Clinical applications of cardiovascular angiogenesis. J Card Surg. 2001 Nov-Dec; 16(6):490-7. PMID: 11925031.
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    81. Shames BD, McIntyre RC, Bensard DD, Pulido EJ, Selzman CH, Reznikov LL, Harken AH, Meng X. Suppression of tumor necrosis factor alpha production by cAMP in human monocytes: dissociation with mRNA level and independent of interleukin-10. J Surg Res. 2001 Aug; 99(2):187-93. PMID: 11469886.
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    82. Raeburn CD, Calkins CM, Zimmerman MA, Song Y, Ao L, Banerjee A, Meng X, Harken AH. Vascular cell adhesion molecule--1 expression is obligatory for endotoxin-induced myocardial neutrophil accumulation and contractile dysfunction. Surgery. 2001 Aug; 130(2):319-25. PMID: 11490366.
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    83. Cleveland JC, Raeburn C, Harken AH. Clinical applications of ischemic preconditioning: from head to toe. Surgery. 2001 Jun; 129(6):664-7. PMID: 11391362.
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    84. Selzman CH, Miller SA, Zimmerman MA, Harken AH. The case for beta-adrenergic blockade as prophylaxis against perioperative cardiovascular morbidity and mortality. Arch Surg. 2001 Mar; 136(3):286-90. PMID: 11231847.
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    85. Harken AH. The role, focus, and funding of research in a department of surgery. Arch Surg. 2001 Feb; 136(2):154-7. PMID: 11177131.
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    86. Donnahoo KK, Meng X, Ao L, Ayala A, Shames BD, Cain MP, Harken AH, Meldrum DR. Differential cellular immunolocalization of renal tumour necrosis factor-alpha production during ischaemia versus endotoxaemia. Immunology. 2001 Jan; 102(1):53-8. PMID: 11168637; PMCID: PMC1783149.
    87. Robinson TN, Morrell TD, Pomerantz BJ, Heimbach JK, Cairns CB, Harken AH. Therapeutically accessible clinical cardiac states. J Am Coll Surg. 2000 Oct; 191(4):452-63. PMID: 11030251.
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    88. Pomerantz BJ, Robinson TN, Morrell TD, Heimbach JK, Banerjee A, Harken AH. Selective mitochondrial adenosine triphosphate-sensitive potassium channel activation is sufficient to precondition human myocardium. J Thorac Cardiovasc Surg. 2000 Aug; 120(2):387-92. PMID: 10917958.
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    89. Cairns CB, Panacek EA, Harken AH, Banerjee A. Bench to bedside: tumor necrosis factor-alpha: from inflammation to resuscitation. Acad Emerg Med. 2000 Aug; 7(8):930-41. PMID: 10958139.
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    90. Pomerantz BJ, Robinson TN, Heimbach JK, Calkins CM, Miller SA, Banerjee A, Harken AH. Selective mitochondrial KATP channel opening controls human myocardial preconditioning: too much of a good thing? Surgery. 2000 Aug; 128(2):368-73. PMID: 10923018.
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    91. Pomerantz BJ, Joo K, Shames BD, Cleveland JC, Banerjee A, Harken AH. Adenosine preconditioning reduces both pre and postischemic arrhythmias in human myocardium. J Surg Res. 2000 May 15; 90(2):191-6. PMID: 10792962.
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    92. Cain BS, Meldrum DR, Cleveland JC, Meng X, Banerjee A, Harken AH. L-type blockers inhibit myocardial preconditioning. J Mol Cell Cardiol. 2000 May; 32(5):861-2. PMID: 10775491.
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    93. Finlayson C, Arya J, Galandiuk S, Harken A. The meaning of surgery. Surgery. 2000 Apr; 127(4):361-2. PMID: 10776423.
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    94. Donnahoo KK, Meldrum DR, Shenkar R, Chung CS, Abraham E, Harken AH. Early renal ischemia, with or without reperfusion, activates NFkappaB and increases TNF-alpha bioactivity in the kidney. J Urol. 2000 Apr; 163(4):1328-32. PMID: 10737538.
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    95. Arya J, Finlayson CA, Shames BD, Harken AH, Anderson BO. Stimulated apoptosis as an anti-neoplastic strategy. Surgery. 2000 Apr; 127(4):366-9. PMID: 10776425.
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    96. Harken A, Hartford CE. Invited commentary: surgical residency training. Surgery. 2000 Jan; 127(1):12-3. PMID: 10660752.
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    97. Cain BS, Meldrum DR, Cleveland JC, Meng X, Banerjee A, Harken AH. Clinical L-type Ca(2+) channel blockade prevents ischemic preconditioning of human myocardium. J Mol Cell Cardiol. 1999 Dec; 31(12):2191-7. PMID: 10640446.
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    98. Harken AH. Enough is enough. Arch Surg. 1999 Oct; 134(10):1061-3. PMID: 10522846.
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    99. Cain BS, Meldrum DR, Meng X, Pulido EJ, Shames BD, Selzman CH, Banerjee A, Harken AH. Exogenous calcium preconditions myocardium from patients taking oral sulfonylurea agents. J Surg Res. 1999 Oct; 86(2):171-6. PMID: 10534420.
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    100. Donnahoo KK, Meng X, Ayala A, Cain MP, Harken AH, Meldrum DR. Early kidney TNF-alpha expression mediates neutrophil infiltration and injury after renal ischemia-reperfusion. Am J Physiol. 1999 Sep; 277(3 Pt 2):R922-9. PMID: 10484513.
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    101. Meldrum DR, Meng X, Shames BD, Pomerantz B, Donnahoo KK, Banerjee A, Harken AH. Liposomal delivery of heat-shock protein 72 into the heart prevents endotoxin-induced myocardial contractile dysfunction. Surgery. 1999 Aug; 126(2):135-41. PMID: 10455875.
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    102. Meldrum DR, Cain BS, Meng X, Cleveland JC, Shames BD, Donnahoo KK, Banerjee A, Harken AH. Calcium preconditioning, but not ischemic preconditioning, bypasses the adenosine triphosphate-dependent potassium (KATP) channel. J Surg Res. 1999 Jul; 85(1):77-82. PMID: 10383841.
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    103. Cain BS, Meldrum DR, Dinarello CA, Meng X, Joo KS, Banerjee A, Harken AH. Tumor necrosis factor-alpha and interleukin-1beta synergistically depress human myocardial function. Crit Care Med. 1999 Jul; 27(7):1309-18. PMID: 10446825.
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    104. Meldrum DR, Partrick DA, Sheridan BC, Moore EE, Harken AH. Kinetics of interleukin-11 release after cardiopulmonary bypass. J Thorac Cardiovasc Surg. 1999 Jul; 118(1):193-5. PMID: 10384204.
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    105. Meng X, Brown JM, Ao L, Shames BD, Banerjee A, Harken AH. Reduction of infarct size in the rat heart by LPS preconditioning is associated with expression of angiogenic growth factors and increased capillary density. Shock. 1999 Jul; 12(1):25-31. PMID: 10468048.
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    106. Meng X, Banerjee A, Ao L, Meldrum DR, Cain BS, Shames BD, Harken AH. Inhibition of myocardial TNF-alpha production by heat shock. A potential mechanism of stress-induced cardioprotection against postischemic dysfunction. Ann N Y Acad Sci. 1999 Jun 30; 874:69-82. PMID: 10415522.
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    107. Cain BS, Meldrum DR, Meng X, Dinarello CA, Shames BD, Banerjee A, Harken AH. p38 MAPK inhibition decreases TNF-alpha production and enhances postischemic human myocardial function. J Surg Res. 1999 May 1; 83(1):7-12. PMID: 10210635.
      View in: PubMed
    108. Meng X, Shames BD, Pulido EJ, Meldrum DR, Ao L, Joo KS, Harken AH, Banerjee A. Adrenergic induction of bimodal myocardial protection: signal transduction and cardiac gene reprogramming. Am J Physiol. 1999 May; 276(5 Pt 2):R1525-33. PMID: 10233047.
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    109. Shames BD, Selzman CH, Pulido EJ, Meng X, Meldrum DR, McIntyre RC, Harken AH, Banerjee A. LPS-Induced NF-kappaB activation and TNF-alpha release in human monocytes are protein tyrosine kinase dependent and protein kinase C independent. J Surg Res. 1999 May 1; 83(1):69-74. PMID: 10210645.
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    110. Selzman CH, Shames BD, McIntyre RC, Banerjee A, Harken AH. The NFkappaB inhibitory peptide, IkappaBalpha, prevents human vascular smooth muscle proliferation. Ann Thorac Surg. 1999 May; 67(5):1227-31; discussion 1231-2. PMID: 10355388.
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    111. Selzman CH, Shames BD, Reznikov LL, Miller SA, Meng X, Barton HA, Werman A, Harken AH, Dinarello CA, Banerjee A. Liposomal delivery of purified inhibitory-kappaBalpha inhibits tumor necrosis factor-alpha-induced human vascular smooth muscle proliferation. Circ Res. 1999 Apr 30; 84(8):867-75. PMID: 10222332.
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    112. Veeramachaneni NK, Harken AH, Cairns CB. Clinical implications of hemoglobin as a nitric oxide carrier. Arch Surg. 1999 Apr; 134(4):434-7. PMID: 10199319.
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    113. Cochrane J, Williams BT, Banerjee A, Harken AH, Burke TJ, Cairns CB, Shapiro JI. Ischemic preconditioning attenuates functional, metabolic, and morphologic injury from ischemic acute renal failure in the rat. Ren Fail. 1999 Mar; 21(2):135-45. PMID: 10088174.
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    114. Zimmerman MA, Selzman CH, Harken AH. Surgical implications of therapeutic angiogenesis. Surgery. 1999 Mar; 125(3):243-9. PMID: 10076607.
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    115. Harken AH. Thomas G. Orr Memorial Lectureship. The general, general surgeon. Am J Surg. 1998 Dec; 176(6):494-6. PMID: 9926777.
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    116. Meldrum DR, Dinarello CA, Shames BD, Cleveland JC, Cain BS, Banerjee A, Meng X, Harken AH. Ischemic preconditioning decreases postischemic myocardial tumor necrosis factor-alpha production. Potential ultimate effector mechanism of preconditioning. Circulation. 1998 Nov 10; 98(19 Suppl):II214-8; discussion II218-9. PMID: 9852905.
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    117. Shames BD, Meldrum DR, Selzman CH, Pulido EJ, Cain BS, Banerjee A, Harken AH, Meng X. Increased levels of myocardial IkappaB-alpha protein promote tolerance to endotoxin. Am J Physiol. 1998 Sep; 275(3 Pt 2):H1084-91. PMID: 9724317.
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    118. Rehring TF, Shapiro JI, Cain BS, Meldrum DR, Cleveland JC, Harken AH, Banerjee A. Mechanisms of pH preservation during global ischemia in preconditioned rat heart: roles for PKC and NHE. Am J Physiol. 1998 Sep; 275(3 Pt 2):H805-13. PMID: 9724283.
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    119. Meldrum DR, Meng X, Dinarello CA, Ayala A, Cain BS, Shames BD, Ao L, Banerjee A, Harken AH. Human myocardial tissue TNFalpha expression following acute global ischemia in vivo. J Mol Cell Cardiol. 1998 Sep; 30(9):1683-9. PMID: 9769224.
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    120. Meldrum DR, Dinarello CA, Cleveland JC, Cain BS, Shames BD, Meng X, Harken AH. Hydrogen peroxide induces tumor necrosis factor alpha-mediated cardiac injury by a P38 mitogen-activated protein kinase-dependent mechanism. Surgery. 1998 Aug; 124(2):291-6; discussion 297. PMID: 9706151.
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    121. Cain BS, Meldrum DR, Joo KS, Wang JF, Meng X, Cleveland JC, Banerjee A, Harken AH. Human SERCA2a levels correlate inversely with age in senescent human myocardium. J Am Coll Cardiol. 1998 Aug; 32(2):458-67. PMID: 9708476.
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    122. Harken AH. Hundreds of years of progress in transfusion medicine [editoria; comment]]. J Am Coll Surg. 1998 Aug; 187(2):199-200. PMID: 9704969.
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    123. Selzman CH, Shames BD, Whitehill TA, Harken AH, McIntyre RC. Class II cytokine receptor ligands inhibit human vascular smooth muscle proliferation. Surgery. 1998 Aug; 124(2):318-26; discussion 326-7. PMID: 9706155.
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    124. Meng X, Brown JM, Ao L, Rowland RT, Nordeen SK, Banerjee A, Harken AH. Myocardial gene reprogramming associated with a cardiac cross-resistant state induced by LPS preconditioning. Am J Physiol. 1998 Aug; 275(2 Pt 1):C475-83. PMID: 9688602.
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    125. Meng X, Ao L, Meldrum DR, Cain BS, Shames BD, Selzman CH, Banerjee A, Harken AH. TNF-alpha and myocardial depression in endotoxemic rats: temporal discordance of an obligatory relationship. Am J Physiol. 1998 Aug; 275(2 Pt 2):R502-8. PMID: 9688686.
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    126. Shames BD, Selzman CH, Meng X, Meldrum DR, Cain BS, Harken AH. Genes don't count. Arch Surg. 1998 Jun; 133(6):667-9. PMID: 9637469.
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    127. Cain BS, Meldrum DR, Dinarello CA, Meng X, Banerjee A, Harken AH. Adenosine reduces cardiac TNF-alpha production and human myocardial injury following ischemia-reperfusion. J Surg Res. 1998 May; 76(2):117-23. PMID: 9698510.
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    128. Cairns CB, Walther J, Harken AH, Banerjee A. Mitochondrial oxidative phosphorylation thermodynamic efficiencies reflect physiological organ roles. Am J Physiol. 1998 May; 274(5 Pt 2):R1376-83. PMID: 9612405.
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    129. Cain BS, Meldrum DR, Meng X, Pulido EJ, Banerjee A, Harken AH. Therapeutic antidysrhythmic and functional protection in human atria. J Surg Res. 1998 May; 76(2):143-8. PMID: 9698514.
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    130. Meldrum DR, Meng X, Sheridan BC, McIntyre RC, Harken AH, Banerjee A. Tissue-specific protein kinase C isoforms differentially mediate macrophage TNFalpha and IL-1beta production. Shock. 1998 Apr; 9(4):256-60. PMID: 9565253.
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    131. Selzman CH, McIntyre RC, Shames BD, Whitehill TA, Banerjee A, Harken AH. Interleukin-10 inhibits human vascular smooth muscle proliferation. J Mol Cell Cardiol. 1998 Apr; 30(4):889-96. PMID: 9602438.
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    132. Cain BS, Meldrum DR, Meng X, Shames BD, Banerjee A, Harken AH. Calcium preconditioning in human myocardium. Ann Thorac Surg. 1998 Apr; 65(4):1065-70. PMID: 9564929.
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    133. Cain BS, Meldrum DR, Harken AH, McIntyre RC. The physiologic basis for anticytokine clinical trials in the treatment of sepsis. J Am Coll Surg. 1998 Mar; 186(3):337-50. PMID: 9510266.
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    134. Meldrum DR, Cleveland JC, Cain BS, Meng X, Harken A. Increased myocardial tumor necrosis factor-alpha in a crystalloid-perfused model of cardiac ischemia-reperfusion injury. Ann Thorac Surg. 1998 Feb; 65(2):439-43. PMID: 9485242.
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    135. Meldrum DR, Cain BS, Cleveland JC, Meng X, Ayala A, Banerjee A, Harken AH. Adenosine decreases post-ischaemic cardiac TNF-alpha production: anti-inflammatory implications for preconditioning and transplantation. Immunology. 1997 Dec; 92(4):472-7. PMID: 9497488; PMCID: PMC1364152.
    136. Meldrum DR, McIntyre RC, Sheridan BC, Cleveland JC, Fullerton DA, Harken AH. L-arginine decreases alveolar macrophage proinflammatory monokine production during acute lung injury by a nitric oxide synthase-dependent mechanism. J Trauma. 1997 Dec; 43(6):888-93. PMID: 9420100.
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    137. Cairns CB, Ferroggiaro AA, Walther JM, Harken AH, Banerjee A. Postischemic administration of succinate reverses the impairment of oxidative phosphorylation after cardiac ischemia and reperfusion injury. Circulation. 1997 Nov 4; 96(9 Suppl):II-260-5. PMID: 9386108.
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    138. Meldrum DR, Cleveland JC, Moore EE, Partrick DA, Banerjee A, Harken AH. Adaptive and maladaptive mechanisms of cellular priming. Ann Surg. 1997 Nov; 226(5):587-98. PMID: 9389392; PMCID: PMC1191120.
    139. Meng X, Ao L, Brown JM, Meldrum DR, Sheridan BC, Cain BS, Banerjee A, Harken AH. LPS induces late cardiac functional protection against ischemia independent of cardiac and circulating TNF-alpha. Am J Physiol. 1997 Oct; 273(4 Pt 2):H1894-902. PMID: 9362258.
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    140. Meldrum DR, Shenkar R, Sheridan BC, Cain BS, Abraham E, Harken AH. Hemorrhage activates myocardial NFkappaB and increases TNF-alpha in the heart. J Mol Cell Cardiol. 1997 Oct; 29(10):2849-54. PMID: 9344778.
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    141. Cain BS, Meldrum DR, Selzman CH, Cleveland JC, Meng X, Sheridan BC, Banerjee A, Harken AH. Surgical implications of vascular endothelial physiology. Surgery. 1997 Sep; 122(3):516-26. PMID: 9308608.
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    142. Cleveland JC, Meldrum DR, Rowland RT, Cain BS, Meng X, Gamboni-Robertson F, Banerjee A, Harken AH. Ischemic preconditioning of human myocardium: protein kinase C mediates a permissive role for alpha 1-adrenoceptors. Am J Physiol. 1997 Aug; 273(2 Pt 2):H902-8. PMID: 9277509.
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    143. Meldrum DR, Cleveland JC, Rowland RT, Banerjee A, Harken AH, Meng X. Early and delayed preconditioning: differential mechanisms and additive protection. Am J Physiol. 1997 Aug; 273(2 Pt 2):H725-33. PMID: 9277489.
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    144. Cleveland JC, Meldrum DR, Cain BS, Banerjee A, Harken AH. Oral sulfonylurea hypoglycemic agents prevent ischemic preconditioning in human myocardium. Two paradoxes revisited. Circulation. 1997 Jul 1; 96(1):29-32. PMID: 9236412.
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    145. Cain BS, Meldrum DR, Joo KS, Davis RJ, Harken AH. Diastolic hibernation masquerading as constrictive pericarditis. J Card Surg. 1997 Jul-Aug; 12(4):235-7. PMID: 9591176.
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    146. Selzman CH, Turner AS, Johnson SM, Cain BS, Harken AH, Whitehill TA. Chronic estrogen replacement inhibits aortic intimal hyperplasia independent of serum lipids. J Card Surg. 1997 Jul-Aug; 12(4):228-34. PMID: 9591175.
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    147. Cain BS, Harken AH. On "Surgical treatment of diastolic dysfunction". J Card Surg. 1997 Jul-Aug; 12(4):238-9. PMID: 9591177.
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    148. Rowland RT, Meng X, Cleveland JC, Meldrum DR, Harken AH, Brown JM. LPS-induced delayed myocardial adaptation enhances acute preconditioning to optimize postischemic cardiac function. Am J Physiol. 1997 Jun; 272(6 Pt 2):H2708-15. PMID: 9227550.
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    149. Meldrum DR, Cleveland JC, Sheridan BC, Rowland RT, Selzman CH, Banerjee A, Harken AH. Alpha-adrenergic activation of myocardial NF kappa B during hemorrhage. J Surg Res. 1997 May; 69(2):268-76. PMID: 9224392.
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    150. Meldrum DR, Cleveland JC, Meng X, Sheridan BC, Gamboni F, Cain BS, Harken AH, Banerjee A. Protein kinase C isoform diversity in preconditioning. J Surg Res. 1997 Apr; 69(1):183-7. PMID: 9202667.
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    151. Meldrum DR, Cleveland JC, Meng X, Sheridan BC, Banerjee A, Harken AH. Hemorrhage induces acute cardioadaptation to ischemia-reperfusion by an alpha1-adrenoceptor-mediated, protein synthesis-independent mechanism. Am J Physiol. 1997 Feb; 272(2 Pt 2):R718-25. PMID: 9124500.
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    152. Meng X, Ao L, Brown JM, Fullerton DA, Banerjee A, Harken AH. Nitric oxide synthase is not involved in cardiac contractile dysfunction in a rat model of endotoxemia without shock. Shock. 1997 Feb; 7(2):111-8. PMID: 9035287.
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    153. Cleveland JC, Meldrum DR, Rowland RT, Banerjee A, Harken AH. Adenosine preconditioning of human myocardium is dependent upon the ATP-sensitive K+ channel. J Mol Cell Cardiol. 1997 Jan; 29(1):175-82. PMID: 9040032.
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    154. Winter CB, Cleveland JC, Butler KL, Bensard DB, Mitchell MB, Harken AH, Banerjee A. Facilitative interactions between noradrenergic and purinergic signaling during preconditioning of the rat heart. J Mol Cell Cardiol. 1997 Jan; 29(1):163-73. PMID: 9040031.
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    155. Cleveland JC, Meldrum DR, Rowland RT, Banerjee A, Harken AH. Preconditioning and hypothermic cardioplegia protect human heart equally against ischemia. Ann Thorac Surg. 1997 Jan; 63(1):147-52. PMID: 8993257.
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    156. Cleveland JC, Wollmering MM, Meldrum DR, Rowland RT, Rehring TF, Sheridan BC, Harken AH, Banerjee A. Ischemic preconditioning in human and rat ventricle. Am J Physiol. 1996 Nov; 271(5 Pt 2):H1786-94. PMID: 8945892.
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    157. Meldrum DR, Sheridan BC, Cleveland JC, Fullerton DA, Banerjee A, Harken AH. Neutrophils are required for endotoxin-induced myocardial cross-tolerance to ischemia-reperfusion injury. Arch Surg. 1996 Nov; 131(11):1203-8. PMID: 8911261.
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    158. Meldrum DR, Cleveland JC, Sheridan BC, Rowland RT, Banerjee A, Harken AH. Differential effects of adenosine preconditioning on the postischemic rat myocardium. J Surg Res. 1996 Oct; 65(2):159-64. PMID: 8903463.
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    159. Meng X, Brown JM, Ao L, Nordeen SK, Franklin W, Harken AH, Banerjee A. Endotoxin induces cardiac HSP70 and resistance to endotoxemic myocardial depression in rats. Am J Physiol. 1996 Oct; 271(4 Pt 1):C1316-24. PMID: 8897839.
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    160. Meldrum DR, Cleveland JC, Mitchell MB, Rowland RT, Banerjee A, Harken AH. Constructive priming of myocardium against ischemia-reperfusion injury. Shock. 1996 Oct; 6(4):238-42. PMID: 8902938.
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    161. Meldrum DR, Cleveland JC, Sheridan BC, Rowland RT, Banerjee A, Harken AH. Cardiac preconditioning with calcium: clinically accessible myocardial protection. J Thorac Cardiovasc Surg. 1996 Sep; 112(3):778-86. PMID: 8800168.
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    162. Meldrum DR, Cleveland JC, Mitchell MB, Sheridan BC, Gamboni-Robertson F, Harken AH, Banerjee A. Protein kinase C mediates Ca2(+)-induced cardioadaptation to ischemia-reperfusion injury. Am J Physiol. 1996 Sep; 271(3 Pt 2):R718-26. PMID: 8853396.
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    163. Meng X, Cleveland JC, Rowland RT, Mitchell MB, Brown JM, Banerjee A, Harken AH. Norepinephrine-induced sustained myocardial adaptation to ischemia is dependent on alpha 1-adrenoceptors and protein synthesis. J Mol Cell Cardiol. 1996 Sep; 28(9):2017-25. PMID: 8899560.
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    164. Meng X, Brown JM, Ao L, Banerjee A, Harken AH. Norepinephrine induces cardiac heat shock protein 70 and delayed cardioprotection in the rat through alpha 1 adrenoceptors. Cardiovasc Res. 1996 Aug; 32(2):374-83. PMID: 8796125.
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    165. Cleveland JC, Meldrum DR, Rowland RT, Sheridan BC, Banerjee A, Harken AH. The obligate role of protein kinase C in mediating clinically accessible cardiac preconditioning. Surgery. 1996 Aug; 120(2):345-52; discussion 352-3. PMID: 8751603.
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    166. Fullerton DA, Eisenach JH, McIntyre RC, Friese RS, Sheridan BC, Roe GB, Agrafojo J, Banerjee A, Harken AH. Inhaled nitric oxide prevents pulmonary endothelial dysfunction after mesenteric ischemia-reperfusion. Am J Physiol. 1996 Aug; 271(2 Pt 1):L326-31. PMID: 8770072.
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    167. Meldrum DR, Cleveland JC, Rowland RT, Banerjee A, Harken AH. Calcium-induced inotropy is in part mediated by protein kinase C. J Surg Res. 1996 Jul 1; 63(2):400-5. PMID: 8661233.
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    168. Friese RS, Fullerton DA, McIntyre RC, Rehring TF, Agrafojo J, Banerjee A, Harken AH. NO prevents neutrophil-mediated pulmonary vasomotor dysfunction in acute lung injury. J Surg Res. 1996 Jun; 63(1):23-8. PMID: 8661166.
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    169. Sheridan BC, McIntyre RC, Meldrum DR, Cleveland JC, Agrafojo J, Banerjee A, Harken AH, Fullerton DA. Microtubules regulate pulmonary vascular smooth muscle contraction. J Surg Res. 1996 May; 62(2):284-7. PMID: 8632653.
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    170. Meldrum DR, Cleveland JC, Sheridan BC, Rowland RT, Banerjee A, Harken AH. Cardiac surgical implications of calcium dyshomeostasis in the heart. Ann Thorac Surg. 1996 Apr; 61(4):1273-80. PMID: 8607709.
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    171. Meldrum DR, Harken AH. On "preconditioning of skeletal muscle: application to dynamic cardiomyoplasty" by C. David Ianuzzo, et al. J Card Surg. 1996 Mar-Apr; 11(2):109-10. PMID: 8811403.
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    172. Cleveland JC, Meldrum DR, Rowland RT, Banerjee A, Harken AH. Optimal myocardial preservation: cooling, cardioplegia, and conditioning. Ann Thorac Surg. 1996 Feb; 61(2):760-8. PMID: 8572815.
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    173. Rehring TF, Brew EC, Friese RS, Banerjee A, Harken AH. Clinically accessible cell signaling: second messengers in sepsis and trauma. J Surg Res. 1996 Jan; 60(1):270-7. PMID: 8592426.
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    174. Brew EC, Mitchell MB, Rehring TF, Gamboni-Robertson F, McIntyre RC, Harken AH, Banerjee A. Role of bradykinin in cardiac functional protection after global ischemia-reperfusion in rat heart. Am J Physiol. 1995 Oct; 269(4 Pt 2):H1370-8. PMID: 7485570.
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    175. Rowland RT, Meng X, Ao L, Terada LS, Harken AH, Brown JM. Mechanisms of immature myocardial tolerance to ischemia: phenotypic differences in antioxidants, stress proteins, and oxidases. Surgery. 1995 Aug; 118(2):446-52. PMID: 7638763.
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    176. Rehring TF, Brew EC, Friese RS, Banerjee A, Harken AH. Cardiac preconditioning protects against irreversible injury rather than attenuating stunning. J Surg Res. 1995 Jul; 59(1):111-4. PMID: 7630112.
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    177. Fullerton DA, McIntyre RC, Hahn AR, Agrafojo J, Koike K, Meng X, Banerjee A, Harken AH. Dysfunction of cGMP-mediated pulmonary vasorelaxation in endotoxin-induced acute lung injury. Am J Physiol. 1995 Jun; 268(6 Pt 1):L1029-35. PMID: 7611425.
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    178. Brew EC, Mitchell MB, Harken AH. Fibroblast growth factors in operative wound healing. J Am Coll Surg. 1995 Apr; 180(4):499-504. PMID: 7719561.
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    179. Kelly PA, Mann DE, Reiter MJ, Harken AH. Atrial fibrillation after implantable cardioverter defibrillator implantation. Pacing Clin Electrophysiol. 1995 Mar; 18(3 Pt 1):379-85. PMID: 7770356.
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    180. Mitchell MB, Meng X, Ao L, Brown JM, Harken AH, Banerjee A. Preconditioning of isolated rat heart is mediated by protein kinase C. Circ Res. 1995 Jan; 76(1):73-81. PMID: 8001280.
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    181. Kelly PA, Mann DE, Harken AH, Manart FD, Reiter MJ. Implantation of an automatic defibrillator using a new nonthoracotomy approach. Pacing Clin Electrophysiol. 1994 Dec; 17(12 Pt 1):2247-54. PMID: 7885931.
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    182. Fullerton DA, Hahn AR, Banerjee A, Harken AH. Pulmonary vascular smooth muscle relaxation by cGMP- versus cAMP-mediated mechanisms. J Surg Res. 1994 Aug; 57(2):259-63. PMID: 7913147.
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    183. Friese RS, Rehring TF, Wollmering M, Moore EE, Ketch LL, Banerjee A, Harken AH. Trauma primes cells. Shock. 1994 May; 1(5):388-94. PMID: 7743343.
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    184. McIntyre RC, Harken AH, Fullerton DA. Mechanisms of pulmonary vascular control in normal and injured lungs. Surgery. 1994 Mar; 115(3):273-5. PMID: 8128350.
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    185. Bensard DD, Banerjee A, McIntyre RC, Berens RL, Harken AH. Endotoxin disrupts beta-adrenergic signal transduction in the heart. Arch Surg. 1994 Feb; 129(2):198-204; discussion 204-5. PMID: 8304831.
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    186. Fullerton DA, Mitchell MB, McIntyre RC, Banerjee A, Campbell DN, Harken AH, Grover FL. Cold ischemia and reperfusion each produce pulmonary vasomotor dysfunction in the transplanted lung. J Thorac Cardiovasc Surg. 1993 Dec; 106(6):1213-7. PMID: 8246563.
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    187. Meldrum DR, Mitchell MB, Banerjee A, Harken AH. Cardiac preconditioning. Induction of endogenous tolerance to ischemia-reperfusion injury. Arch Surg. 1993 Nov; 128(11):1208-11. PMID: 8239983.
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    188. Banerjee A, Locke-Winter C, Rogers KB, Mitchell MB, Brew EC, Cairns CB, Bensard DD, Harken AH. Preconditioning against myocardial dysfunction after ischemia and reperfusion by an alpha 1-adrenergic mechanism. Circ Res. 1993 Oct; 73(4):656-70. PMID: 8396503.
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    189. Fullerton DA, Hahn AR, Koike K, Banerjee A, Harken AH. Intracellular mechanisms of pulmonary vasomotor dysfunction in acute lung injury caused by mesenteric ischemia-reperfusion. Surgery. 1993 Aug; 114(2):360-6; discussion 366-7. PMID: 8393598.
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    190. Mitchell MB, Winter CB, Banerjee A, Harken AH. The relationship between ischemia-reperfusion injury, myocardial stunning and cardiac preconditioning. Surg Gynecol Obstet. 1993 Jul; 177(1):97-114. PMID: 8322165.
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    191. Mitchell MB, Winter CB, Banerjee A, Harken AH. Inhibition of sarcoplasmic reticulum calcium release reduces myocardial stunning. J Surg Res. 1993 May; 54(5):411-7. PMID: 8361166.
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    192. Mitchell MB, Winter CB, Locke-Winter CR, Banerjee A, Harken AH. Cardiac preconditioning does not require myocardial stunning. Ann Thorac Surg. 1993 Feb; 55(2):395-400. PMID: 8431049.
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    193. Bensard DD, Anderson BO, Banerjee A, Nelson DW, Poggetti RS, Berens RL, Harken A. Platelet activating factor alters receptor-coupled function in the isolated perfused rat heart. J Surg Res. 1992 Oct; 53(4):321-5. PMID: 1328766.
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    194. Mitchell MB, Winter CB, Banerjee A, Harken A. Prophylaxis against perioperative cardiac ischemia-reperfusion injury. Surgery. 1992 Jul; 112(1):1-2. PMID: 1621216.
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    195. Anderson BO, Harken A. Carl John Wiggers' visionary views on vivisection. Ann Surg. 1992 Jul; 216(1):80-6. PMID: 1632706; PMCID: PMC1242550.
    196. Brown JM, Anderson BO, Repine JE, Shanley PF, White CW, Grosso MA, Banerjee A, Bensard DD, Harken A. Neutrophils contribute to TNF induced myocardial tolerance to ischaemia. J Mol Cell Cardiol. 1992 May; 24(5):485-95. PMID: 1635073.
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    197. Grosso MA, Banerjee A, St Cyr JA, Rogers KB, Brown JM, Clarke DR, Campbell DN, Harken A. Cardiac 5'-nucleotidase activity increases with age and inversely relates to recovery from ischemia. J Thorac Cardiovasc Surg. 1992 Feb; 103(2):206-9. PMID: 1735985.
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    198. Nelson DW, Brown JM, Banerjee A, Bensard DD, Rogers KB, Locke-Winter CR, Anderson BO, Harken A. Pretreatment with a nontoxic derivative of endotoxin induces functional protection against cardiac ischemia/reperfusion injury. Surgery. 1991 Aug; 110(2):365-9. PMID: 1858044.
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    199. Anderson BO, Poggetti RS, Shanley PF, Bensard DD, Pitman JM, Nelson DW, Whitman GJ, Banerjee A, Harken A. Primed neutrophils injure rat lung through a platelet-activating factor-dependent mechanism. J Surg Res. 1991 May; 50(5):510-4. PMID: 1710005.
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    200. Anderson BO, Bensard DD, Brown JM, Repine JE, Shanley PF, Leff JA, Terada LS, Banerjee A, Harken A. FNLP injures endotoxin-primed rat lung by neutrophil-dependent and -independent mechanisms. Am J Physiol. 1991 Feb; 260(2 Pt 2):R413-20. PMID: 1847603.
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    201. Anderson BO, Brown JM, Shanley PF, Bensard DD, Harken A. Marginating neutrophils are reversibly adherent to normal lung endothelium. Surgery. 1991 Jan; 109(1):51-61. PMID: 1845819.
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    202. Anderson BO, Harken A. Multiple organ failure: inflammatory priming and activation sequences promote autologous tissue injury. J Trauma. 1990 Dec; 30(12 Suppl):S44-9. PMID: 2174983.
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    203. Brown JM, Harken A, Sharefkin JB. Recombinant DNA and surgery. Ann Surg. 1990 Aug; 212(2):178-86. PMID: 1973891; PMCID: PMC1358054.
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    205. Bensard DD, Brown JM, Anderson BO, Banerjee A, Shanley PF, Grosso MA, Whitman GJ, Harken A. Induction of endogenous tissue antioxidant enzyme activity attenuates myocardial reperfusion injury. J Surg Res. 1990 Aug; 49(2):126-31. PMID: 2199733.
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    206. Brown JM, White CW, Terada LS, Grosso MA, Shanley PF, Mulvin DW, Banerjee A, Whitman GJ, Harken A, Repine JE. Interleukin 1 pretreatment decreases ischemia/reperfusion injury. Proc Natl Acad Sci U S A. 1990 Jul; 87(13):5026-30. PMID: 2367521; PMCID: PMC54254.
    207. Harken DE, Harken A. Anti-antivivisection. Have we waited too long? Arch Surg. 1989 Dec; 124(12):1366-7. PMID: 2589957.
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    208. Harken A, Vernon TM. An "erg" of epidemiology. Am J Surg. 1989 Nov; 158(5):393. PMID: 2554738.
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    209. Brown JM, Grosso MA, Whitman GJ, Banerjee A, Terada LS, Repine JE, Harken A. The coincidence of myocardial reperfusion injury and hydrogen peroxide production in the isolated rat heart. Surgery. 1989 Apr; 105(4):496-501. PMID: 2928952.
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    210. Grosso MA, Brown JM, Viders DE, Mulvin DW, Banerjee A, Velasco SE, Repine JE, Harken A. Xanthine oxidase-derived oxygen radicals induce pulmonary edema via direct endothelial cell injury. J Surg Res. 1989 Apr; 46(4):355-60. PMID: 2495387.
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    211. Brown JM, Grosso MA, Terada LS, Whitman GJ, Banerjee A, White CW, Harken A, Repine JE. Endotoxin pretreatment increases endogenous myocardial catalase activity and decreases ischemia-reperfusion injury of isolated rat hearts. Proc Natl Acad Sci U S A. 1989 Apr; 86(7):2516-20. PMID: 2648406; PMCID: PMC286944.
    212. Brown JM, Grosso MA, Banerjee A, Whitman GJ, Repine JE, Harken A. Erythrocyte catalase decreases cardiac reperfusion injury. Curr Surg. 1989 Mar-Apr; 46(2):122-4. PMID: 2736964.
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    213. Whitman GJ, Kieval RS, Brown J, Banerjee A, Grosso MA, Harken A. Optimal hypothermic preservation of arrested myocardium in isolated perfused rabbit hearts: a 31P NMR study. Surgery. 1989 Jan; 105(1):100-8. PMID: 2911797.
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    214. Brown JM, Terada LS, Grosso MA, Whitman GJ, Velasco SE, Patt A, Harken A, Repine JE. Hydrogen peroxide mediates reperfusion injury in the isolated rat heart. Mol Cell Biochem. 1988 Dec; 84(2):173-5. PMID: 3148110.
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    215. Brown JM, Grosso MA, Reiter MJ, Mann DE, Whitman GJ, Harken A. Chronic supraventricular tachycardia can cause severe ventricular dysfunction, which can be surgically repaired. J Thorac Cardiovasc Surg. 1988 Nov; 96(5):796-9. PMID: 3184972.
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    216. Terada LS, Beehler CJ, Banerjee A, Brown JM, Grosso MA, Harken A, McCord JM, Repine JE. Hyperoxia and self- or neutrophil-generated O2 metabolites inactivate xanthine oxidase. J Appl Physiol (1985). 1988 Nov; 65(5):2349-53. PMID: 3209579.
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    217. Baxter BT, Moore EE, Synhorst DP, Reiter MJ, Harken A. Graded experimental myocardial contusion: impact on cardiac rhythm, coronary artery flow, ventricular function, and myocardial oxygen consumption. J Trauma. 1988 Oct; 28(10):1411-7. PMID: 3172298.
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    218. Brown JM, Grosso MA, Whitman GJ, Terada LS, Repine JE, Harken A. Cardiac oxidase systems mediate oxygen metabolite reperfusion injury. Surgery. 1988 Aug; 104(2):266-71. PMID: 3135626.
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    219. Addonizio VP, Fisher CA, Strauss JF, Ewan VA, Rickles FR, Rosato EF, Harken AH, Inouye WY. Preliminary characterization of the procoagulant material in human ascites. Surgery. 1987 Jun; 101(6):753-62. PMID: 3589968.
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    220. Harken AH. Presidential address: Natural selection in university surgery. Surgery. 1986 Aug; 100(2):129-33. PMID: 3738744.
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    221. Whitman GJ, Kieval RS, Seeholzer S, McDonald G, Simson MB, Harken AH. Recovery of left ventricular function after graded cardiac ischemia as predicted by myocardial P-31 nuclear magnetic resonance. Surgery. 1985 Apr; 97(4):428-35. PMID: 3983818.
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    222. Wetstein L, Michelson EL, Moore EN, Harken AH. Evaluation of arrhythmogenicity of surgically induced endocardial versus ischemic myocardial damage. J Thorac Cardiovasc Surg. 1984 Apr; 87(4):571-6. PMID: 6708577.
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    223. Harken AH, Josephson ME. Recurrent ventricular tachycardia: how effective is surgical management? Am J Surg. 1983 Jun; 145(6):718-23. PMID: 6859410.
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    224. Harken AH, Josephson ME. When is myocardial mapping clinically valuable? Am J Surg. 1983 Jun; 145(6):746-51. PMID: 6859411.
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    225. Addonizio VP, Wetstein L, Fisher CA, Feldman P, Strauss JF, Harken AH. Mediation of cardiac ischemia by thromboxanes released from human platelets. Surgery. 1982 Aug; 92(2):292-8. PMID: 7048597.
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    226. Wetstein L, Michelson EL, Simson MB, Moore EN, Harken AH. Initiation of ventricular tachyarrhythmia with programmed stimulation: sensitivity and specificity in an experimental canine model. Surgery. 1982 Aug; 92(2):206-11. PMID: 7101123.
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    227. Harken AH, Horowitz LN, Josephson ME. Surgical correction of recurrent sustained ventricular tachycardia following complete repair of tetralogy of Fallot. J Thorac Cardiovasc Surg. 1980 Nov; 80(5):779-81. PMID: 7431975.
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    228. Abemayor E, Harken AH, Koop CE. Multiple sequential pulmonary resections for metastatic pheochromocytoma with long-term survival. Am J Surg. 1980 Nov; 140(5):696-7. PMID: 7435832.
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    229. Harken AH, Horowitz LN, Josephson ME. Comparison of standard aneurysmectomy and aneurysmectomy with directed endocardial resection for the treatment of recurrent sustained ventricular tachycardia. J Thorac Cardiovasc Surg. 1980 Oct; 80(4):527-34. PMID: 7421287.
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    230. Rastegar H, Arger P, Harken AH. Evaluation and therapy of mediastinal thymic cyst. Am Surg. 1980 Apr; 46(4):236-8. PMID: 7386988.
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    231. Harken A, Josephson ME, Horowitz LN. Surgical endocardial resection for the treatment of malignant ventricular tachycardia. Ann Surg. 1979 Oct; 190(4):456-60. PMID: 485619; PMCID: PMC1344508.
    232. Crawford PE, Stephenson LW, MacVaugh H, Harken A, Edmunds LH. Is an intermediate cardiac surgical intensive care unit really necessary? Heart Lung. 1979 Jul-Aug; 8(4):685-9. PMID: 256556.
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    233. Harken A, Pringle JM, Badoux S. Autonomic control of pulmonary trapped gas volume in subhuman primates. Am Surg. 1978 Sep; 44(9):554-8. PMID: 102225.
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    234. Harden WR, Simson MB, Barlow CH, Soriano R, Harken A. Display of epicardial ischemia by reduced nicotamide adenine dinucleotide fluorescence photography, electron microscopy, and ST segment mapping. Surgery. 1978 Jun; 83(6):732-40. PMID: 205964.
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    235. Oram-Smith JC, Mullen JL, Harken A, Fitts WT. Direct right atrial catheterization for total parenteral nutrition. Surgery. 1978 Mar; 83(3):274-6. PMID: 415377.
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    236. Harken A, Woods M, Haut MJ, Delivoria-Papadopoulos M. Alteration of oxyhemoglobin affinity in canine erythrocytes. Am Surg. 1977 Dec; 43(12):831-4. PMID: 202182.
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    237. Barlow CH, Harken A, Chance B. Evaluation of cardiac ischemia by NADH fluroescence photography. Ann Surg. 1977 Dec; 186(6):737-40. PMID: 203234; PMCID: PMC1396508.
    238. Harken AH, Woods M. The influence of coronary arterial pH on myocardial oxygen demand. Surgery. 1977 Jun; 81(6):696-700. PMID: 16352.
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    239. Harken AH. Oxygen, politics and the American Revolution (with a note on the bicentennial of phlogiston). Ann Surg. 1976 Nov; 184(5):645-50. PMID: 791165; PMCID: PMC1345500.
    240. Harken A, O'connor NE. The influence of clinically undetectable pulmonary edema on small airway closure in the dog. Ann Surg. 1976 Aug; 184(2):183-8. PMID: 782388; PMCID: PMC1344429.
    241. Woods M, Scott RN, Harken A. Practical considerations for the use of a pulmonary artery thermistor catheter. Surgery. 1976 Apr; 79(4):469-75. PMID: 769224.
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    242. Harken A, Woods M. The influence of oxyhemoglobin affinity on tissue oxygen consumption. Ann Surg. 1976 Feb; 183(2):130-5. PMID: 2111; PMCID: PMC1344074.
    243. Harken A, Woods M, Wright CB. Influence of endotoxin on tissue respiration and oxygen dissociation in an isolated canine hind limb. Am Surg. 1975 Nov; 41(11):704-9. PMID: 242247.
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    244. Harken A. The influence of pulsatile perfusion on oxygen uptake by the isolated canine hind limb. J Thorac Cardiovasc Surg. 1975 Aug; 70(2):237-41. PMID: 239295.
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    245. Harken A, Gabel RA, Fencl V, Moore FD. Hydrochloric acid in the correction of metabolic alkalosis. Arch Surg. 1975 Jul; 110(7):819-21. PMID: 237496.
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    246. Harken A. A routine for safe, effective endotracheal suctioning. Am Surg. 1975 Jul; 41(7):398-404. PMID: 1147389.
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    247. Dunegan LJ, Knight DC, Harken A, O'Conner N, Morgan A. Lung thermal volume in pulmonary edema: effect of positive end expiratory pressure. Ann Surg. 1975 Jun; 181(6):809-12. PMID: 1094968; PMCID: PMC1343899.
    248. Harken A, Pringle JM, Solomon NB, Sharma GV. Effects of parasympathetic blockade on pulmonary gas trapping in the subhuman primate. Am Surg. 1975 Apr; 41(4):193-7. PMID: 1122070.
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    249. Giordano J, Harken A. Effect of continuous positive pressure ventilation on cardiac output. Am Surg. 1975 Apr; 41(4):221-4. PMID: 1092239.
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    250. Harken AH, Brennan MF, Smith B, Barsamian EM. The hemodynamic response to positive end-expiratory ventilation in hypovolemic patients. Surgery. 1974 Nov; 76(5):786-93. PMID: 4608221.
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    251. Harken AH, Shochat SJ. Gram-positive peritonitis in children. Am J Surg. 1973 Jun; 125(6):769-72. PMID: 4122827.
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    252. Van Praagh R, Harken AH, Delisle G, Ando M, Gross RE. Total anomalous pulmonary venous drainage to the coronary sinus. A revised procedure for its correction. J Thorac Cardiovasc Surg. 1972 Jul; 64(1):132-5. PMID: 5053952.
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    253. Harken AH, Filler RM. The use of the umbilical artery and muscle pH monitoring in neonatal cardiopulmonary bypass. J Thorac Cardiovasc Surg. 1972 Jun; 63(6):973-6. PMID: 5028686.
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