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    Aleksandra Leligdowicz, MD, PhD

    TitlePostdoctoral Scholar
    SchoolUCSF School of Medicine
    DepartmentCardiovascular Research Inst
    Address401 Parnassus Ave, LangPorter
    San Francisco CA 94143
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      Collapse Biography 
      Collapse Education and Training
      University of TorontoFellowshipInterdepartmental Division of Critical Care Medicine2015
      University of British ColumbiaResidencyInternal Medicine2013
      McGill UniversityMDCMFaculty of Medicine2010
      Oxford UniversityDPhilWeatherall Institute of Molecular Medicine2008
      University of ManitobaBSc distinctionFaculty of Science2002

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Bartz RR, Gantner D, Gordon AC, Leligdowicz A, McNamee JJ, Murthy S, Nichol A, Webb S, et al. Who Says There Is No "I" in Team? Achieving Individual Success in Collaborative Clinical Research in Critical Care. Am J Respir Crit Care Med. 2016 Oct 1; 194(7):911-912. PMID: 27689708.
        View in: PubMed
      2. Leligdowicz A, Fischer WA, Uyeki TM, Fletcher TE, Adhikari NK, Portella G, Lamontagne F, Clement C, Jacob ST, Rubinson L, Vanderschuren A, Hajek J, Murthy S, Ferri M, Crozier I, Ibrahima E, Lamah MC, Schieffelin JS, Brett-Major D, Bausch DG, Shindo N, Chan AK, O'Dempsey T, Mishra S, Jacobs M, Dickson S, Lyon GM, Fowler RA. Ebola virus disease and critical illness. Crit Care. 2016; 20(1):217. PMID: 27468829.
        View in: PubMed
      3. Jallow S, Leligdowicz A, Kramer HB, Onyango C, Cotten M, Wright C, Whittle HC, McMichael A, Dong T, Kessler BM, Rowland-Jones SL. Correction. The presence of prolines in the flanking region of an immunodominant HIV-2 gag epitope influences the quality and quantity of the epitope generated. Eur J Immunol. 2015 Sep; 45(9):2701. PMID: 26343564.
        View in: PubMed
      4. Leligdowicz A, Fan E. Extracorporeal life support for severe acute respiratory distress syndrome. Curr Opin Crit Care. 2015 Feb; 21(1):13-9. PMID: 25517890.
        View in: PubMed
      5. Murthy S, Leligdowicz A, Adhikari NK. Intensive care unit capacity in low-income countries: a systematic review. PLoS One. 2015; 10(1):e0116949. PMID: 25617837; PMCID: PMC4305307.
      6. Goldenberg NM, Leligdowicz A, Slutsky AS, Friedrich JO, Lee WL. Is nosocomial infection really the major cause of death in sepsis? Crit Care. 2014; 18(5):540. PMID: 25672933; PMCID: PMC4331295.
      7. Reikie BA, Adams RC, Leligdowicz A, Ho K, Naidoo S, Ruck CE, de Beer C, Preiser W, Cotton MF, Speert DP, Esser M, Kollmann TR. Altered innate immune development in HIV-exposed uninfected infants. J Acquir Immune Defic Syndr. 2014 Jul 1; 66(3):245-55. PMID: 24732876; PMCID: PMC4146715.
      8. Leligdowicz A, Dodek PM, Norena M, Wong H, Kumar A, Kumar A. Association between source of infection and hospital mortality in patients who have septic shock. Am J Respir Crit Care Med. 2014 May 15; 189(10):1204-13. PMID: 24635548.
        View in: PubMed
      9. de Silva TI, Peng Y, Leligdowicz A, Zaidi I, Li L, Griffin H, Blais ME, Vincent T, Saraiva M, Yindom LM, van Tienen C, Easterbrook P, Jaye A, Whittle H, Dong T, Rowland-Jones SL. Correlates of T-cell-mediated viral control and phenotype of CD8(+) T cells in HIV-2, a naturally contained human retroviral infection. Blood. 2013 May 23; 121(21):4330-9. PMID: 23558015.
        View in: PubMed
      10. de Silva T, Leligdowicz A, Rowland-Jones S. Effect of HIV-2 infection on HIV-1 disease progression. N Engl J Med. 2012 Nov 15; 367(20):1961-2; author reply 1962-3. PMID: 23150974.
        View in: PubMed
      11. Reikie BA, Adams RC, Ruck CE, Ho K, Leligdowicz A, Pillay S, Naidoo S, Fortuno ES, de Beer C, Preiser W, Cotton MF, Speert DP, Esser M, Kollmann TR. Ontogeny of Toll-like receptor mediated cytokine responses of South African infants throughout the first year of life. PLoS One. 2012; 7(9):e44763. PMID: 23028609; PMCID: PMC3441420.
      12. Zhang Y, Peng Y, Yan H, Xu K, Saito M, Wu H, Chen X, Ranasinghe S, Kuse N, Powell T, Zhao Y, Li W, Zhang X, Feng X, Li N, Leligdowicz A, Xu X, John M, Takiguchi M, McMichael A, Rowland-Jones S, Dong T. Multilayered defense in HLA-B51-associated HIV viral control. J Immunol. 2011 Jul 15; 187(2):684-91. PMID: 21670313; PMCID: PMC3166850.
      13. Leligdowicz A, Onyango C, Yindom LM, Peng Y, Cotten M, Jaye A, McMichael A, Whittle H, Dong T, Rowland-Jones S. Highly avid, oligoclonal, early-differentiated antigen-specific CD8+ T cells in chronic HIV-2 infection. Eur J Immunol. 2010 Jul; 40(7):1963-72. PMID: 20411566.
        View in: PubMed
      14. Yindom LM, Leligdowicz A, Martin MP, Gao X, Qi Y, Zaman SM, van der Loeff MS, van Tienen C, Jaye A, Aveika A, Worwui A, Diatta M, Vincent T, Whittle HC, Rowland-Jones SL, Walton R, Carrington M. Influence of HLA class I and HLA-KIR compound genotypes on HIV-2 infection and markers of disease progression in a Manjako community in West Africa. J Virol. 2010 Aug; 84(16):8202-8. PMID: 20519398; PMCID: PMC2916551.
      15. Onyango CO, Leligdowicz A, Yokoyama M, Sato H, Song H, Nakayama EE, Shioda T, de Silva T, Townend J, Jaye A, Whittle H, Rowland-Jones S, Cotten M. HIV-2 capsids distinguish high and low virus load patients in a West African community cohort. Vaccine. 2010 May 26; 28 Suppl 2:B60-7. PMID: 20510746.
        View in: PubMed
      16. van der Loeff MF, Larke N, Kaye S, Berry N, Ariyoshi K, Alabi A, van Tienen C, Leligdowicz A, Sarge-Njie R, da Silva Z, Jaye A, Ricard D, Vincent T, Jones SR, Aaby P, Jaffar S, Whittle H. Undetectable plasma viral load predicts normal survival in HIV-2-infected people in a West African village. Retrovirology. 2010; 7:46. PMID: 20482865; PMCID: PMC2887382.
      17. Tienen Cv, van der Loeff MS, Zaman SM, Vincent T, Sarge-Njie R, Peterson I, Leligdowicz A, Jaye A, Rowland-Jones S, Aaby P, Whittle H. Two distinct epidemics: the rise of HIV-1 and decline of HIV-2 infection between 1990 and 2007 in rural Guinea-Bissau. J Acquir Immune Defic Syndr. 2010 Apr; 53(5):640-7. PMID: 19841588.
        View in: PubMed
      18. Leligdowicz A, Feldmann J, Jaye A, Cotten M, Dong T, McMichael A, Whittle H, Rowland-Jones S. Direct relationship between virus load and systemic immune activation in HIV-2 infection. J Infect Dis. 2010 Jan 1; 201(1):114-22. PMID: 19938978.
        View in: PubMed
      19. Feldmann J, Leligdowicz A, Jaye A, Dong T, Whittle H, Rowland-Jones SL. Downregulation of the T-cell receptor by human immunodeficiency virus type 2 Nef does not protect against disease progression. J Virol. 2009 Dec; 83(24):12968-72. PMID: 19812166; PMCID: PMC2786859.
      20. Jallow S, Vincent T, Leligdowicz A, De Silva T, Van Tienen C, Alabi A, Sarge-Njie R, Aaby P, Corrah T, Whittle H, Jaye A, Vanham G, Rowland-Jones S, Janssens W. Presence of a multidrug-resistance mutation in an HIV-2 variant infecting a treatment-naive individual in Caio, Guinea Bissau. Clin Infect Dis. 2009 Jun 15; 48(12):1790-3. PMID: 19438401.
        View in: PubMed
      21. Mendy ME, Kaye S, Le Roux E, Kirk GD, Jeng-Barry A, McConkey S, Cotten M, Kuniholm MH, Leligdowicz A, Hainaut P, Rowland-Jones S, Whittle H. Application of a novel, rapid, and sensitive oligonucleotide ligation assay for detection of cancer-predicting mutations in the precore and basal core promoter of hepatitis B virus. J Clin Microbiol. 2008 Aug; 46(8):2723-30. PMID: 18508941; PMCID: PMC2519494.
      22. Leligdowicz A, Rowland-Jones S. Tenets of protection from progression to AIDS: lessons from the immune responses to HIV-2 infection. Expert Rev Vaccines. 2008 Apr; 7(3):319-31. PMID: 18393602.
        View in: PubMed
      23. Leligdowicz A, Yindom LM, Onyango C, Sarge-Njie R, Alabi A, Cotten M, Vincent T, da Costa C, Aaby P, Jaye A, Dong T, McMichael A, Whittle H, Rowland-Jones S. Robust Gag-specific T cell responses characterize viremia control in HIV-2 infection. J Clin Invest. 2007 Oct; 117(10):3067-74. PMID: 17823657; PMCID: PMC1964515.
      24. Jensen ML, Dave S, Schim van der Loeff M, da Costa C, Vincent T, Leligdowicz A, Benn CS, Roth A, Ravn H, Lisse IM, Whittle H, Aaby P. Vaccinia scars associated with improved survival among adults in rural Guinea-Bissau. PLoS One. 2006; 1:e101. PMID: 17183634; PMCID: PMC1762358.
      25. Gill KK, Leligdowicz A, Luo M, Bielawny T, Brunham R, Plummer FA. Identification of four novel HLA-A alleles from an East African population by high-resolution sequence-based typing. Hum Immunol. 2006 Oct; 67(10):833-8. PMID: 17055361.
        View in: PubMed
      26. Leligdowicz A, Katwere M, Piloya T, Ronald A, Kambugu A, Katabira E. Challenges in diagnosis, treatment and follow-up of patients presenting with central nervous system infections in a resource-limited setting. Mcgill J Med. 2006 Jan; 9(1):39-48. PMID: 19529809; PMCID: PMC2687896.
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