Alex Vecchio, PhD
|School||UCSF School of Medicine|
|Department||Biochemistry and Biophysics|
|Address||600 16th Street|
San Francisco CA 94158
|University at Buffalo, The State University of New York||Ph.D. Structural Biology||2011||Hauptman-Woodward Institute & Department of Structural Biology|
|Rochester Institute of Technology||B.S. Biology||2000||Thomas H. Gosnell School of Life Sciences|
|National Institutes of Health (NIGMS)||2012
||2015||Ruth L. Kirschstein NRSA Postdoctoral Fellowship|
Dr. Vecchio is a Postdoctoral Fellow at the University of California, San Francisco (USCF) in the laboratory of Professor Robert M. Stroud, Department of Biochemistry & Biophysics. Alex earned his Ph.D. in Structural Biology at the Hauptman-Woodward Medical Research Institute and the University at Buffalo, The State University of New York (SUNY), and obtained a B.S. in Biology from the Rochester Institute of Technology. His research interests currently focus on X-ray crystallographic determination of integral membrane proteins of epithelial tight junctions.
Epithelia separate, protect, and shape the tissues of the human body, forming organs and glands. Integral membrane proteins found at tight junctions of adjacent epithelial cells are essential for these tissues ability to function as physical and chemical barriers, while still allowing for transport of molecules of various size and ionic charge to pass paracellularly, in-between cells. The goal of Alex's research is to determine the three-dimensional structures of these proteins to extend insight into their function; leading toward a better understanding of the tight junction multiprotein complex and the development of novel therapeutics aimed at ameliorating tight junction-related diseases.
, X-ray crystallography
, Protein biochemistry
, Recombinant protein expression
, Protein purification
, Protein crystallization
, Integral membrane proteins
, Cell culture
, Protein:lipid interactions
, Protein:detergent interactions
, Protein:drug interactions
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