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    Alex Vecchio, PhD

    TitlePostdoctoral Scholar
    SchoolUCSF School of Medicine
    DepartmentBiochemistry and Biophysics
    Address600 16th Street
    San Francisco CA 94158
    Phone415-476-3937
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      Collapse Biography 
      Collapse Education and Training
      University at Buffalo, The State University of New YorkPh.D. Structural BiologyHauptman-Woodward Institute & Department of Structural Biology2011
      Rochester Institute of TechnologyB.S. BiologyThomas H. Gosnell School of Life Sciences2000
      Collapse Awards and Honors
      National Institutes of Health (NIGMS)2012 - 2015Ruth L. Kirschstein NRSA Postdoctoral Fellowship

      Collapse Overview 
      Collapse Overview
      Dr. Vecchio is a Postdoctoral Fellow at the University of California, San Francisco (USCF) in the laboratory of Professor Robert M. Stroud, Department of Biochemistry & Biophysics. Alex earned his Ph.D. in Structural Biology at the Hauptman-Woodward Medical Research Institute and the University at Buffalo, The State University of New York (SUNY), and obtained a B.S. in Biology from the Rochester Institute of Technology. His research interests currently focus on X-ray crystallographic determination of integral membrane proteins of epithelial tight junctions.

      Epithelia separate, protect, and shape the tissues of the human body, forming organs and glands. Integral membrane proteins found at tight junctions of adjacent epithelial cells are essential for these tissues ability to function as physical and chemical barriers, while still allowing for transport of molecules of various size and ionic charge to pass paracellularly, in-between cells. The goal of Alex's research is to determine the three-dimensional structures of these proteins to extend insight into their function; leading toward a better understanding of the tight junction multiprotein complex and the development of novel therapeutics aimed at ameliorating tight junction-related diseases.

      Collapse Interests
      Structural biology, X-ray crystallography, Protein biochemistry, Recombinant protein expression, Protein purification, Protein crystallization, Integral membrane proteins, Cell culture, Protein:lipid interactions, Protein:detergent interactions, Protein:drug interactions

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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Lucido MJ, Orlando BJ, Vecchio AJ, Malkowski MG. Crystal Structure of Aspirin-Acetylated Human Cyclooxygenase-2: Insight into the Formation of Products with Reversed Stereochemistry. Biochemistry. 2016 Mar 1; 55(8):1226-38. PMID: 26859324.
        View in: PubMed
      2. Vecchio AJ, Orlando BJ, Nandagiri R, Malkowski MG. Investigating substrate promiscuity in cyclooxygenase-2: the role of Arg-120 and residues lining the hydrophobic groove. J Biol Chem. 2012 Jul 13; 287(29):24619-30. PMID: 22637474; PMCID: PMC3397890.
      3. Vecchio AJ, Malkowski MG. The structure of NS-398 bound to cyclooxygenase-2. J Struct Biol. 2011 Nov; 176(2):254-8. PMID: 21843643; PMCID: PMC3185125.
      4. Vecchio AJ, Malkowski MG. The structural basis of endocannabinoid oxygenation by cyclooxygenase-2. J Biol Chem. 2011 Jun 10; 286(23):20736-45. PMID: 21489986; PMCID: PMC3121521.
      5. Dong L, Vecchio AJ, Sharma NP, Jurban BJ, Malkowski MG, Smith WL. Human cyclooxygenase-2 is a sequence homodimer that functions as a conformational heterodimer. J Biol Chem. 2011 May 27; 286(21):19035-46. PMID: 21467029; PMCID: PMC3099718.
      6. Vecchio AJ, Simmons DM, Malkowski MG. Structural basis of fatty acid substrate binding to cyclooxygenase-2. J Biol Chem. 2010 Jul 16; 285(29):22152-63. PMID: 20463020; PMCID: PMC2903402.
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