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    Alexander Leo Laemmle, PhD, MD

    TitlePostdoctoral Scholar
    SchoolUCSF School of Medicine
    DepartmentRegeneration Medicine
    Address513 Parnassus Ave
    San Francisco CA 94143
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      Collapse Biography 
      Collapse Education and Training
      University of Bern, SwitzerlandM.D.School of Medicine2004
      University of Bern, SwitzerlandPh.D.Laboratory of Visceral and Transplantation Surgery2010
      University of Bern, SwitzerlandBoard Certification in PediatricsUniversity of Bern2015
      University of Zurich, SwitzerlandBoard Certification in Pediatric Metabolic MedicineUniversity of Zurich, Switzerland2015
      University of Zurich, SwitzerlandPostdoctoral FellowshipDivision of Metabolic Diseases2016
      Collapse Awards and Honors
      University of Bern, Switzerland2008Keystone Symposia Scholarship Award; Vancouver, Canada
      Children`s University Hospital Zurich, Switzerland2015Research Grant by the EMDO Foundation Zurich
      Children`s University Hospital Zurich, Switzerland2015 - 2016Research Grant by the Forschungszentrum für das Kind
      University of California, San Francisco2016Research Fellowship by the Novartis Foundation for Medical-Biological Research
      University of California, San Francisco2017 - 2018Research Fellowship by the Fondazione Valeria e Ettore Rossi

      Collapse ORNG Applications 
      Collapse Featured Publications

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Laemmle A, Gallagher RC, Keogh A, Stricker T, Gautschi M, Nuoffer JM, Baumgartner MR, Häberle J. Frequency and Pathophysiology of Acute Liver Failure in Ornithine Transcarbamylase Deficiency (OTCD). PLoS One. 2016; 11(4):e0153358. PMID: 27070778.
        View in: PubMed
      2. Laemmle A, Stricker T, Häberle J, et al. Switch from Sodium Phenylbutyrate to Glycerol Phenylbutyrate Improved Metabolic Stability in an Adolescent with Ornithine Transcarbamylase Deficiency. JIMD Rep. 2016 Mar 22. PMID: 27000017.
        View in: PubMed
      3. Kölker S, Cazorla AG, Valayannopoulos V, Lund AM, Burlina AB, Sykut-Cegielska J, Wijburg FA, Teles EL, Zeman J, Dionisi-Vici C, Baric I, Karall D, Augoustides-Savvopoulou P, Aksglaede L, Arnoux JB, Avram P, Baumgartner MR, Blasco-Alonso J, Chabrol B, Chakrapani A, Chapman K, I Saladelafont EC, Couce ML, de Meirleir L, Dobbelaere D, Dvorakova V, Furlan F, Gleich F, Gradowska W, Grünewald S, Jalan A, Häberle J, Haege G, Lachmann R, Laemmle A, Langereis E, de Lonlay P, Martinelli D, Matsumoto S, Mühlhausen C, de Baulny HO, Ortez C, Peña-Quintana L, Ramadža DP, Rodrigues E, Scholl-Bürgi S, Sokal E, Staufner C, Summar ML, Thompson N, Vara R, Pinera IV, Walter JH, Williams M, Burgard P. Erratum to: The phenotypic spectrum of organic acidurias and urea cycle disorders. Part 1: the initial presentation. J Inherit Metab Dis. 2015 Nov; 38(6):1155-6. PMID: 26077420.
        View in: PubMed
      4. Kölker S, Cazorla AG, Valayannopoulos V, Lund AM, Burlina AB, Sykut-Cegielska J, Wijburg FA, Teles EL, Zeman J, Dionisi-Vici C, Baric I, Karall D, Augoustides-Savvopoulou P, Aksglaede L, Arnoux JB, Avram P, Baumgartner MR, Blasco-Alonso J, Chabrol B, Chakrapani A, Chapman K, I Saladelafont EC, Couce ML, de Meirleir L, Dobbelaere D, Dvorakova V, Furlan F, Gleich F, Gradowska W, Grünewald S, Jalan A, Häberle J, Haege G, Lachmann R, Laemmle A, Langereis E, de Lonlay P, Martinelli D, Matsumoto S, Mühlhausen C, de Baulny HO, Ortez C, Peña-Quintana L, Ramadža DP, Rodrigues E, Scholl-Bürgi S, Sokal E, Staufner C, Summar ML, Thompson N, Vara R, Pinera IV, Walter JH, Williams M, Burgard P. The phenotypic spectrum of organic acidurias and urea cycle disorders. Part 1: the initial presentation. J Inherit Metab Dis. 2015 Nov; 38(6):1041-57. PMID: 25875215.
        View in: PubMed
      5. Laemmle A, Hahn D, Hu L, Rüfenacht V, Gautschi M, Leibundgut K, Nuoffer JM, Häberle J. Fatal hyperammonemia and carbamoyl phosphate synthetase 1 (CPS1) deficiency following high-dose chemotherapy and autologous hematopoietic stem cell transplantation. Mol Genet Metab. 2015 Mar; 114(3):438-44. PMID: 25639153.
        View in: PubMed
      6. Laemmle A, Balmer C, Doell C, Sass JO, Häberle J, Baumgartner MR. Propionic acidemia in a previously healthy adolescent with acute onset of dilated cardiomyopathy. Eur J Pediatr. 2014 Jul; 173(7):971-4. PMID: 24916042.
        View in: PubMed
      7. Portmann S, Fahrner R, Lechleiter A, Keogh A, Overney S, Laemmle A, Mikami K, Montani M, Tschan MP, Candinas D, Stroka D. Antitumor effect of SIRT1 inhibition in human HCC tumor models in vitro and in vivo. Mol Cancer Ther. 2013 Apr; 12(4):499-508. PMID: 23339189.
        View in: PubMed
      8. Laemmle A, Lechleiter A, Roh V, Schwarz C, Portmann S, Furer C, Keogh A, Tschan MP, Candinas D, Vorburger SA, Stroka D. Inhibition of SIRT1 impairs the accumulation and transcriptional activity of HIF-1a protein under hypoxic conditions. PLoS One. 2012; 7(3):e33433. PMID: 22479397; PMCID: PMC3316573.
      9. Wagner M, Roh V, Strehlen M, Laemmle A, Stroka D, Egger B, Trochsler M, Hunt KK, Candinas D, Vorburger SA. Effective treatment of advanced colorectal cancer by rapamycin and 5-FU/oxaliplatin monitored by TIMP-1. J Gastrointest Surg. 2009 Oct; 13(10):1781-90. PMID: 19565301.
        View in: PubMed
      10. Wampfler J, Tschan MP, Shan D, Laemmle A, Leibundgut EO, Baerlocher GM, Stroka D, Fey MF, Britschgi C. SIRT1 is downregulated during neutrophil differentiation of acute promyelocytic leukaemia cells. Br J Haematol. 2009 Aug; 146(3):337-41. PMID: 19466968.
        View in: PubMed
      11. Roh V, Laemmle A, Von Holzen U, Stroka D, Dufour JF, Hunt KK, Candinas D, Vorburger SA. Dual induction of PKR with E2F-1 and IFN-alpha to enhance gene therapy against hepatocellular carcinoma. Cancer Gene Ther. 2008 Oct; 15(10):636-44. PMID: 18535617.
        View in: PubMed
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