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    Anders Persson, PhD

    TitleAssistant Professor
    SchoolUCSF School of Medicine
    DepartmentNeurology
    Address675 Nelson Rising Lane
    San Francisco CA 94158
    Phone415-502-7178
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      Collapse Biography 
      Collapse Education and Training
      University of California, San FranciscoPostdoctoral StudiesGraduate Division
      Collapse Awards and Honors
      University of California San Francisco2005Swedish Society of Medicine
      University of California San Francisco2005Swedish Brain Tumor Foundation
      University of California San Francisco2005 - 2006Swedish Society for Medical Research
      University of California San Francisco2008Sandler Postdoctoral Fellowship Award
      University of California San Francisco2008 - 2009American Brain Tumor Association Fellowship
      University of California San Francisco2010Hellman Family Foundation Early-Career Award
      University of California San Francisco2010American Brain Tumor Association Translational Award
      University of California San Francisco2011UCSF SPORE -Career Developmental Award
      University of California San Francisco2012American Cancer Society Individual Research Award
      University of California San Francisco2013 - 2015NBTS Oligodendroglioma Award
      Universiy of California San Francisco2014 - 2016NIH Exploratory/Developmental Award (R21)
      University of California San Francisco2015 - 2016UCSCF RAP Pilot Award in Basic and Clinical/Translational Sciences

      Collapse Overview 
      Collapse Overview
      Background
      Our research focus on understanding how oncogenic events can transform neural stem cells (NSCs) and oligodendrocyte progenitor cells (OPCs) into distinct types of childhood and adult gliomas. In addition, we have recently identified a previously unrecognized population of potential NSCs with tumorigenic capacity and regenerative potential. We are currently studying the regenerative potential of these cells during normal development and disease. In human gliomas, aggressive therapy leaves behind subpopulations of tumor cells displaying properties of NSCs or OPCs, suggesting a lineage-relationship between the cell of origin and therapy-resistant tumor cells. We and others have confirmed this relationship in genetically-engineered murine models (GEMM) of glioma. We use detailed knowledge about glial cells to identify the intrinsic and environmental components that impact glioma biology. We find that deregulation of NSC- and OPC-related microRNAs (miRNAs) regulate tumor biology in a glioma subtype-specific manner. Reintroduction of a single miRNA can turn glioblastoma (GBM) cells into neurons. We also study whether the cell of origin regulates response to ionizing radiation (IR) and the ability to regulate cell volume. Major goals: (i) Develop GEMM of glioma using relevant oncogenic events to identify the initial steps that transform NSCs and OPCs in a temporal and regional fashion. (ii) Identify drugable targets that drive stemness in glioma. (iii) Study the effect of IR and role of osmotic swelling on glioma biology.

      Identification of a novel NSC population
      We have established a team of collaborators to characterize the tumorigenic capacity potential of a novel NSC population. In addition, we study the regenerative potential using fate-mapping techniques during normal development and following traumatic brain injury (TBI). We also study cell genesis following stress, enriched environment, and exercise.

      Development of IDH1R132H, H3F3A, and PDGF-driven mutant glioma models
      Human gliomas displaying mutations in the isocitrate dehydrogenase 1/2 (IDH1/2) genes are diagnosed in young adults. In high-grade glioblastoma (GBM), H3F3A (K27) and H3F3A (G34) tumors are expressed in young children and adolescent patients, respectively. We are using retroviral (RCAS) transformation of cells expressing the TVA receptor to produce these tumors in mice.

      Targeting stemness in glioblastoma
      Pre-clinical experiments show that radiotherapy and treatment with temozolomide enrich for highly tumorigenic and stem-like tumor cells in human GBMs. We optimize IR regimens to better target these stem-like cells. Our laboratory use GEMMs and human GBM biopsies to study the mechanisms underlying treatment-resistance, including dormancy and epigenetic control of translation of genes. In particular, we identify small non-coding RNAs that regulate glioma biology.

      Osmotic swelling as a therapeutic target in cancer
      High pressure is a major obstacle for uptake in solid tumors, less is known how elevated interstitial fluid pressure impacts tumor biology. We find that high pressure drive tumor proliferation in solid cancers. In this NIH-supported project, we have identified a mechanism that blocks the ability of GBM cells to regulate cell volume, leading to massive apoptosis and reduced survival of xenografted mice. We currently test whether osmotic swelling regulates translational control of genes that drives GBM aggressiveness.


      Collapse ORNG Applications 
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      Collapse Featured Publications

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Lau J, Ilkhanizadeh S, Wang S, Miroshnikova YA, Salvatierra NA, Wong RA, Schmidt C, Weaver VM, Weiss WA, Persson AI. STAT3 Blockade Inhibits Radiation-Induced Malignant Progression in Glioma. Cancer Res. 2015 Oct 15; 75(20):4302-11. PMID: 26282165; PMCID: PMC4609277 [Available on 10/15/16].
      2. Li N, Maly DJ, Chanthery YH, Sirkis DW, Nakamura JL, Berger MS, James CD, Shokat KM, Weiss WA, Persson AI. Radiotherapy followed by aurora kinase inhibition targets tumor-propagating cells in human glioblastoma. Mol Cancer Ther. 2015 Feb; 14(2):419-28. PMID: 25522764; PMCID: PMC4326592 [Available on 02/01/16].
      3. Swartling FJ, Cancer M, Frantz A, Weishaupt H, Persson AI. Deregulated proliferation and differentiation in brain tumors. Cell Tissue Res. 2015 Jan; 359(1):225-54. PMID: 25416506; PMCID: PMC4286433 [Available on 01/01/16].
      4. Ilkanizadeh S, Lau J, Huang M, Foster DJ, Wong R, Frantz A, Wang S, Weiss WA, Persson AI. Glial progenitors as targets for transformation in glioma. Adv Cancer Res. 2014; 121:1-65. PMID: 24889528; PMCID: PMC4270964.
      5. Shchors K, Persson AI, Rostker F, Tihan T, Lyubynska N, Li N, Swigart LB, Berger MS, Hanahan D, Weiss WA, Evan GI. Using a preclinical mouse model of high-grade astrocytoma to optimize p53 restoration therapy. Proc Natl Acad Sci U S A. 2013 Apr 16; 110(16):E1480-9. PMID: 23542378; PMCID: PMC3631679.
      6. Swartling FJ, Bolin S, Phillips JJ, Persson AI. Signals that regulate the oncogenic fate of neural stem cells and progenitors. Exp Neurol. 2014 Oct; 260:56-68. PMID: 23376224; PMCID: PMC3758390.
      7. Swartling FJ, Savov V, Persson AI, Chen J, Hackett CS, Northcott PA, Grimmer MR, Lau J, Chesler L, Perry A, Phillips JJ, Taylor MD, Weiss WA. Distinct neural stem cell populations give rise to disparate brain tumors in response to N-MYC. Cancer Cell. 2012 May 15; 21(5):601-13. PMID: 22624711; PMCID: PMC3360885.
      8. Chanthery YH, Gustafson WC, Itsara M, Persson A, Hackett CS, Grimmer M, Charron E, Yakovenko S, Kim G, Matthay KK, Weiss WA. Paracrine signaling through MYCN enhances tumor-vascular interactions in neuroblastoma. Sci Transl Med. 2012 Jan 4; 4(115):115ra3. PMID: 22218692; PMCID: PMC3402217.
      9. Sugiarto S, Persson AI, Munoz EG, Waldhuber M, Lamagna C, Andor N, Hanecker P, Ayers-Ringler J, Phillips J, Siu J, Lim DA, Vandenberg S, Stallcup W, Berger MS, Bergers G, Weiss WA, Petritsch C. Asymmetry-defective oligodendrocyte progenitors are glioma precursors. Cancer Cell. 2011 Sep 13; 20(3):328-40. PMID: 21907924; PMCID: PMC3297490.
      10. Persson AI, Petritsch C, Swartling FJ, Itsara M, Sim FJ, Auvergne R, Goldenberg DD, Vandenberg SR, Nguyen KN, Yakovenko S, Ayers-Ringler J, Nishiyama A, Stallcup WB, Berger MS, Bergers G, McKnight TR, Goldman SA, Weiss WA. Non-stem cell origin for oligodendroglioma. Cancer Cell. 2010 Dec 14; 18(6):669-82. PMID: 21156288; PMCID: PMC3031116.
      11. Persson AI, Weiss WA. The side story of stem-like glioma cells. Cell Stem Cell. 2009 Mar 6; 4(3):191-2. PMID: 19265652.
        View in: PubMed
      12. Silber J, Lim DA, Petritsch C, Persson AI, Maunakea AK, Yu M, Vandenberg SR, Ginzinger DG, James CD, Costello JF, Bergers G, Weiss WA, Alvarez-Buylla A, Hodgson JG. miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells. BMC Med. 2008; 6:14. PMID: 18577219; PMCID: PMC2443372.
      13. Persson AI, Bull C, Eriksson PS. Requirement for Id1 in opioid-induced oligodendrogenesis in cultured adult rat hippocampal progenitors. Eur J Neurosci. 2006 May; 23(9):2277-88. PMID: 16706836.
        View in: PubMed
      14. Zarnegar P, Persson AI, Ming Y, Terenius L. Opioid-induced regulation of gene expression in PC12 cells stably transfected with mu-opioid receptor. Neurosci Lett. 2006 Apr 3; 396(3):197-201. PMID: 16377088.
        View in: PubMed
      15. Persson AI, Thorlin T, Eriksson PS. Comparison of immunoblotted delta opioid receptor proteins expressed in the adult rat brain and their regulation by growth hormone. Neurosci Res. 2005 May; 52(1):1-9. PMID: 15811547.
        View in: PubMed
      16. Naylor AS, Persson AI, Eriksson PS, Jonsdottir IH, Thorlin T. Extended voluntary running inhibits exercise-induced adult hippocampal progenitor proliferation in the spontaneously hypertensive rat. J Neurophysiol. 2005 May; 93(5):2406-14. PMID: 15615829.
        View in: PubMed
      17. Dahl A, Eriksson PS, Davidsson P, Persson AI, Ekman R, Westman-Brinkmalm A. Demonstration of multiple novel glycoforms of the stem cell survival factor CCg. J Neurosci Res. 2004 Jul 1; 77(1):9-14. PMID: 15197734.
        View in: PubMed
      18. Persson AI, Naylor AS, Jonsdottir IH, Nyberg F, Eriksson PS, Thorlin T. Differential regulation of hippocampal progenitor proliferation by opioid receptor antagonists in running and non-running spontaneously hypertensive rats. Eur J Neurosci. 2004 Apr; 19(7):1847-55. PMID: 15078558.
        View in: PubMed
      19. Persson AI, Thorlin T, Bull C, Eriksson PS. Opioid-induced proliferation through the MAPK pathway in cultures of adult hippocampal progenitors. Mol Cell Neurosci. 2003 Jul; 23(3):360-72. PMID: 12837621.
        View in: PubMed
      20. Persson AI, Thorlin T, Bull C, Zarnegar P, Ekman R, Terenius L, Eriksson PS. Mu- and delta-opioid receptor antagonists decrease proliferation and increase neurogenesis in cultures of rat adult hippocampal progenitors. Eur J Neurosci. 2003 Mar; 17(6):1159-72. PMID: 12670304.
        View in: PubMed
      21. Persson AI, Aberg ND, Oscarsson J, Isaksson OG, Rönnbäck L, Frick F, Sonesson C, Eriksson PS. Expression of delta opioid receptor mRNA and protein in the rat cerebral cortex and cerebellum is decreased by growth hormone. J Neurosci Res. 2003 Feb 15; 71(4):496-503. PMID: 12548705.
        View in: PubMed
      22. Paulson L, Martin P, Persson A, Nilsson CL, Ljung E, Westman-Brinkmalm A, Eriksson PS, Blennow K, Davidsson P. Comparative genome- and proteome analysis of cerebral cortex from MK-801-treated rats. J Neurosci Res. 2003 Feb 15; 71(4):526-33. PMID: 12548708.
        View in: PubMed
      23. Dahl A, Eriksson PS, Persson AI, Karlsson G, Davidsson P, Ekman R, Westman-Brinkmalm A. Proteome analysis of conditioned medium from cultured adult hippocampal progenitors. Rapid Commun Mass Spectrom. 2003; 17(19):2195-202. PMID: 14515317.
        View in: PubMed
      24. Persson PA, Thorlin T, Rönnbäck L, Hansson E, Eriksson PS. Differential expression of delta opioid receptors and mRNA in proliferating astrocytes during the cell cycle. J Neurosci Res. 2000 Aug 15; 61(4):371-5. PMID: 10931523.
        View in: PubMed
      25. Thorlin T, Anders P, Persson I, Eriksson PS, Rönnbäck L, Hansson E. Astrocyte beta1-adrenergic receptor immunoreactivity and agonist induced increases in [Ca2+]i: differential results indicative of a modified membrane receptor. Life Sci. 2000 Aug 4; 67(11):1285-96. PMID: 10972197.
        View in: PubMed
      26. Thorlin T, Persson PA, Eriksson PS, Hansson E, Rönnbäck L. Delta-opioid receptor immunoreactivity on astrocytes is upregulated during mitosis. Glia. 1999 Feb 15; 25(4):370-8. PMID: 10028919.
        View in: PubMed
      27. Thorlin T, Eriksson PS, Persson PA, Aberg ND, Hansson E, Rönnbäck L. Delta-opioid receptors on astroglial cells in primary culture: mobilization of intracellular free calcium via a pertussis sensitive G protein. Neuropharmacology. 1998; 37(3):299-311. PMID: 9681928.
        View in: PubMed
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