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    Anders Persson, PhD

    TitleAssistant Professor
    SchoolUCSF School of Medicine
    DepartmentNeurology
    Address675 Nelson Rising Lane
    San Francisco CA 94143
    Phone415-502-7178

       Biography 
       Education and Training
      University of California, San FranciscoPostdoctoral StudiesGraduate Division
       Awards and Honors
      University of California San Francisco2012American Cancer Society Individual Research Award
      University of California San Francisco2011UCSF SPORE -Career Developmental Award
      University of California San Francisco2010American Brain Tumor Association Translational Award
      University of California San Francisco2010Hellman Family Foundation Early-Career Award
      University of California San Francisco2008Sandler Postdoctoral Fellowship Award
      University of California San Francisco2008 - 2009American Brain Tumor Association Fellowship
      University of California San Francisco2005Swedish Brain Tumor Foundation
      University of California San Francisco2005Swedish Society of Medicine
      University of California San Francisco2005 - 2006Swedish Society for Medical Research

       Overview 
       Overview
      Background
      Dr. Persson is interested in the biological processes that balance cell division and differentiation in neural stem cells (NSCs) and glial progenitors (GPs). Dr. Persson is also interested in how this delicate balance can go wrong in cancer. During neural development, cell division and differentiation in NSCs and GPs is coordinated in a regional and temporal fashion. Transcriptional programs that drive expansion of cells in the brain during fetal and perinatal stages are also active in brain tumors, in particular therapy-resistant and tumor-propagating cells (TPCs) that are thought to underlie relapse in patients. Dr. Persson study brain tumors with a focus on glioma, the most common primary malignancy in adults. Major goals: (i) study how oncogenes and tumor suppressors drive tumorigenesis in NSCs and GPs (ii) develop therapies that target undifferentiated TPCs in pediatric and adult brain tumors.

      Cell of origin in brain tumors.
      Transformation of fetal and postnatal NSCs and GPs isolated from mice and humans serve as an excellent model system for pediatric and adult brain tumors. This system allows Dr. Persson to study how transformation of neural precursor cells contributes to the phenotype of the resulting brain tumor. Dr. Persson’s work suggests that the block in differentiation and proliferation in transformed cells is mediated by microRNAs that repress expression of members of the SOX and HES families. Genetically-engineered murine (GEM) brain tumor models allow Dr. Persson to study the cell of origin for pediatric and adult brain tumors in mice. Dr. Persson and others have used GEM models to study how transformation of NSCs and GPs give rise to gliomas.

      Targeting tumor-propagating cells in brain tumors.
      To effectively study human pediatric and adult brain tumors, Dr. Persson developing protocols that enable propagation of tumors in vitro and in xenografts. GEM brain tumor models enable pre-clinical studies of brain tumors that require an intact blood-brain barrier and functional immune system. Tumor-propagating cells (TPCs) in pediatric and adult brain tumors are resistant to radiotherapy and alkylating agents. Dormancy and an undifferentiated state contribute to resistance against anti-proliferative therapies. To prevent relapse in brain tumor patients, Dr. Persson develop sequential therapy regimens that induce cell cycling or promote differentiation of TPCs. He is also collaborating with several laboratories to study molecular interactions between the tumor microenvironment and TPCs after radiotherapy.
      During his PhD, Dr. Persson studied glial cells, including NSCs. This worked clarified the effects of opioids, exercise and stress on NSCs. After completion of the PhD in 2003, he established a brain tumor research laboratory at Sahlgrenska University Hospital in Sweden. Supported by both Swedish and US Fellowships, he did his postdoctoral training (2005-2008) in Professor William Weiss Laboratory at University of California San Francisco studying cell of origin in murine glioma models and developing new therapies against human glioblastoma. After being promoted to Assistant Adjunct Professor in 2008, he initiated collaborations with multiple research laboratories. In 2012, Dr. Persson was promoted to Assistant Professor In-Residence at Department of Neurology. Financial support and space from the Department of Neurological Surgery and Department of Neurology at UCSF has allowed Dr. Persson to establish his independent laboratory.


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       Bibliographic 
       Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Swartling FJ, Savov V, Persson AI, Chen J, Hackett CS, Northcott PA, Grimmer MR, Lau J, Chesler L, Perry A, Phillips JJ, Taylor MD, Weiss WA. Distinct neural stem cell populations give rise to disparate brain tumors in response to N-MYC. Cancer Cell. 2012 May 15; 21(5):601-13.
        View in: PubMed
      2. Chanthery YH, Gustafson WC, Itsara M, Persson A, Hackett CS, Grimmer M, Charron E, Yakovenko S, Kim G, Matthay KK, Weiss WA. Paracrine signaling through MYCN enhances tumor-vascular interactions in neuroblastoma. Sci Transl Med. 2012 Jan 4; 4(115):115ra3.
        View in: PubMed
      3. Sugiarto S, Persson AI, Munoz EG, Waldhuber M, Lamagna C, Andor N, Hanecker P, Ayers-Ringler J, Phillips J, Siu J, Lim DA, Vandenberg S, Stallcup W, Berger MS, Bergers G, Weiss WA, Petritsch C. Asymmetry-defective oligodendrocyte progenitors are glioma precursors. Cancer Cell. 2011 Sep 13; 20(3):328-40.
        View in: PubMed
      4. Persson AI, Petritsch C, Swartling FJ, Itsara M, Sim FJ, Auvergne R, Goldenberg DD, Vandenberg SR, Nguyen KN, Yakovenko S, Ayers-Ringler J, Nishiyama A, Stallcup WB, Berger MS, Bergers G, McKnight TR, Goldman SA, Weiss WA. Non-stem cell origin for oligodendroglioma. Cancer Cell. 2010 Dec 14; 18(6):669-82.
        View in: PubMed
      5. Persson AI, Weiss WA. The side story of stem-like glioma cells. Cell Stem Cell. 2009 Mar 6; 4(3):191-2.
        View in: PubMed
      6. Silber J, Lim DA, Petritsch C, Persson AI, Maunakea AK, Yu M, Vandenberg SR, Ginzinger DG, James CD, Costello JF, Bergers G, Weiss WA, Alvarez-Buylla A, Hodgson JG. miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells. BMC Med. 2008; 6:14.
        View in: PubMed
      7. Persson AI, Bull C, Eriksson PS. Requirement for Id1 in opioid-induced oligodendrogenesis in cultured adult rat hippocampal progenitors. Eur J Neurosci. 2006 May; 23(9):2277-88.
        View in: PubMed
      8. Zarnegar P, Persson AI, Ming Y, Terenius L. Opioid-induced regulation of gene expression in PC12 cells stably transfected with mu-opioid receptor. Neurosci Lett. 2006 Apr 3; 396(3):197-201.
        View in: PubMed
      9. Persson AI, Thorlin T, Eriksson PS. Comparison of immunoblotted delta opioid receptor proteins expressed in the adult rat brain and their regulation by growth hormone. Neurosci Res. 2005 May; 52(1):1-9.
        View in: PubMed
      10. Naylor AS, Persson AI, Eriksson PS, Jonsdottir IH, Thorlin T. Extended voluntary running inhibits exercise-induced adult hippocampal progenitor proliferation in the spontaneously hypertensive rat. J Neurophysiol. 2005 May; 93(5):2406-14.
        View in: PubMed
      11. Dahl A, Eriksson PS, Davidsson P, Persson AI, Ekman R, Westman-Brinkmalm A. Demonstration of multiple novel glycoforms of the stem cell survival factor CCg. J Neurosci Res. 2004 Jul 1; 77(1):9-14.
        View in: PubMed
      12. Persson AI, Naylor AS, Jonsdottir IH, Nyberg F, Eriksson PS, Thorlin T. Differential regulation of hippocampal progenitor proliferation by opioid receptor antagonists in running and non-running spontaneously hypertensive rats. Eur J Neurosci. 2004 Apr; 19(7):1847-55.
        View in: PubMed
      13. Persson AI, Thorlin T, Bull C, Eriksson PS. Opioid-induced proliferation through the MAPK pathway in cultures of adult hippocampal progenitors. Mol Cell Neurosci. 2003 Jul; 23(3):360-72.
        View in: PubMed
      14. Persson AI, Thorlin T, Bull C, Zarnegar P, Ekman R, Terenius L, Eriksson PS. Mu- and delta-opioid receptor antagonists decrease proliferation and increase neurogenesis in cultures of rat adult hippocampal progenitors. Eur J Neurosci. 2003 Mar; 17(6):1159-72.
        View in: PubMed
      15. Persson AI, Aberg ND, Oscarsson J, Isaksson OG, Rönnbäck L, Frick F, Sonesson C, Eriksson PS. Expression of delta opioid receptor mRNA and protein in the rat cerebral cortex and cerebellum is decreased by growth hormone. J Neurosci Res. 2003 Feb 15; 71(4):496-503.
        View in: PubMed
      16. Paulson L, Martin P, Persson A, Nilsson CL, Ljung E, Westman-Brinkmalm A, Eriksson PS, Blennow K, Davidsson P. Comparative genome- and proteome analysis of cerebral cortex from MK-801-treated rats. J Neurosci Res. 2003 Feb 15; 71(4):526-33.
        View in: PubMed
      17. Dahl A, Eriksson PS, Persson AI, Karlsson G, Davidsson P, Ekman R, Westman-Brinkmalm A. Proteome analysis of conditioned medium from cultured adult hippocampal progenitors. Rapid Commun Mass Spectrom. 2003; 17(19):2195-202.
        View in: PubMed
      18. Persson PA, Thorlin T, Rönnbäck L, Hansson E, Eriksson PS. Differential expression of delta opioid receptors and mRNA in proliferating astrocytes during the cell cycle. J Neurosci Res. 2000 Aug 15; 61(4):371-5.
        View in: PubMed
      19. Thorlin T, Anders P, Persson I, Eriksson PS, Rönnbäck L, Hansson E. Astrocyte beta1-adrenergic receptor immunoreactivity and agonist induced increases in [Ca2+]i: differential results indicative of a modified membrane receptor. Life Sci. 2000 Aug 4; 67(11):1285-96.
        View in: PubMed
      20. Thorlin T, Persson PA, Eriksson PS, Hansson E, Rönnbäck L. Delta-opioid receptor immunoreactivity on astrocytes is upregulated during mitosis. Glia. 1999 Feb 15; 25(4):370-8.
        View in: PubMed
      21. Thorlin T, Eriksson PS, Persson PA, Aberg ND, Hansson E, Rönnbäck L. Delta-opioid receptors on astroglial cells in primary culture: mobilization of intracellular free calcium via a pertussis sensitive G protein. Neuropharmacology. 1998; 37(3):299-311.
        View in: PubMed
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