Sign in to see private stats on your profile page — or add photo, interests, videos, mentoring, etc.

    Andrea Hasenstaub, PhD

    TitleAssistant Professor
    SchoolUCSF School of Medicine
    Address675 Nelson Rising Lane
    San Francisco CA 94158
    vCardDownload vCard

      Collapse Overview 
      Collapse Overview
      Andrea Hasenstaub, PhD, is an Assistant Professor in the Coleman Memorial Laboratories in the Department of Otolaryngology-Head and Neck Surgery (OHNS) at the University of California, San Francisco. She received her BS in Mathematics and Engineering at the California Institute of Technology in Pasadena, California; a M.Phil. in Biological Anthropology from Cambridge University, England; and a PhD in Neurobiology at Yale University in New Haven, Connecticut, followed by a fellowship at the Salk Institute in La Jolla, California.

      Dr. Hasenstaub’s research is focused on understanding the genetic, cellular, and network operation of specific cell types in the mouse and human auditory cortex. One line of research focuses on inhibitory microcircuitry in normal and diseased brains. Within the cortex, diverse types of local circuit inhibitory neuron play vital roles in regulating and timing activity, and are key mediators of long-term developmental plasticity. Central auditory processing disorders, such as hyperacusis or tinnitus, may result in part from failure of cortical inhibitory networks to properly control the strength, timing, or plasticity of excitatory activity. These neurons' dysfunction is also implicated in broader neurodevelopmental disorders including schizophrenia, autism, epilepsy, and bipolar disorder. Treatments for these common and devastating diseases will require both a conceptual understanding of cortical interneurons' circuit functions, and a mechanistic understanding of their interactions.

      Exciting advances in optical and genetic technology now bring this understanding within reach, by allowing us to systematically measure and manipulate properties of specific cell populations to answer basic questions about their function. Under what conditions are different kind of cortical neuron engaged? What computations do different types of neurons enable? How does each type's activation affect input integration in its targets? How can long-range or neuromodulatory inputs dynamically regulate these interactions, and how does this match moment-to-moment changes in cognitive or behavioral requirements? And what can we infer about design principles common to all neural systems, by studying the biophysical strategies interneurons adopt to fill these circuit roles?

      A second line of research focuses on electrophysiological and genetic studies of human cerebral cortex. The majority of our information about cortical microcircuitry has been derived from studies in model systems, particularly mice, rats, ferrets, and cats. These studies have provided fundamental insight into the many aspects of cortical organization which are conserved across species. However, human neocortex differs from that of model systems in numerous ways including the presence of additional neuron types, specializations in conserved neuron types, altered patterns of local and long-range connections, and the presence of additional cytoarchitectonic areas. These evolutionarily recent specializations underlie the differences in cognitive capacity in humans compared to other species. By studying temporal and frontal cortex acutely resected from human surgical patients, we gain direct access to the cellular mechanisms of human brain function and disease, including the numerous human-specific aspects of cortical organization which cannot be directly studied in model systems.

      Our overall goal is to identify the conditions under which different kinds of cortical neuron are engaged, understand what computations they enable cortical networks to perform, and establish the biophysical and circuit mechanisms by which they allow these computations to occur. We hope that this will guide us in developing a low-level mechanistic understanding of how their plasticity in aging, hearing loss, and other types of brain injury underlies the functional losses observed in these conditions.

      Auditory physiology; central auditory processing

      In vivo and in vitro recordings, mouse neurophysiology, human neurophysiology

      Professional interests:
      Hearing; auditory cortex; thalamus; cross-modal and modulatory influences; cell type specificity; comparative studies

      • BS: California Institute of Technology, Mathematics and Engineering
      • M. Phil.: Cambridge University, Biological Anthropology
      • MS and PhD: Yale University, Neurobiology

      Collapse ORNG Applications 
      Collapse Websites
      Collapse Awarded Grants

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Larimer P, Spatazza J, Espinosa JS, Tang Y, Kaneko M, Hasenstaub AR, Stryker MP, Alvarez-Buylla A, et al. Caudal Ganglionic Eminence Precursor Transplants Disperse and Integrate as Lineage-Specific Interneurons but Do Not Induce Cortical Plasticity. Cell Rep. 2016 Jul 14. PMID: 27425623.
        View in: PubMed
      2. Seybold BA, Phillips EA, Schreiner CE, Hasenstaub AR. Inhibitory Actions Unified by Network Integration. Neuron. 2015 Sep 23; 87(6):1181-92. PMID: 26402602; PMCID: PMC4635400 [Available on 09/23/16].
      3. Ledochowitsch P, Yazdan-Shahmorad A, Bouchard KE, Diaz-Botia C, Hanson TL, He JW, Seyboldt B, Olivero E, Phillips EA, Blanche TJ, Schreiner CE, Hasenstaub A, Chang EF, Sabes PN, Maharbiz MM. Strategies for optical control and simultaneous electrical readout of extended cortical circuits. J Neurosci Methods. 2015 Dec 30; 256:220-31. PMID: 26296286.
        View in: PubMed
      4. Hasenstaub A, Otte S, Callaway E. Cell Type-Specific Control of Spike Timing by Gamma-Band Oscillatory Inhibition. Cereb Cortex. 2016 Feb; 26(2):797-806. PMID: 25778344.
        View in: PubMed
      5. Nienborg H, Hasenstaub A, Nauhaus I, Taniguchi H, Huang ZJ, Callaway EM. Contrast dependence and differential contributions from somatostatin- and parvalbumin-expressing neurons to spatial integration in mouse V1. J Neurosci. 2013 Jul 3; 33(27):11145-54. PMID: 23825418; PMCID: PMC3718383.
      6. Hasenstaub AR, Callaway EM. Paint it black (or red, or green): optical and genetic tools illuminate inhibitory contributions to cortical circuit function. Neuron. 2010 Sep 9; 67(5):681-4. PMID: 20826299.
        View in: PubMed
      7. Hasenstaub A, Otte S, Callaway E, Sejnowski TJ. Metabolic cost as a unifying principle governing neuronal biophysics. Proc Natl Acad Sci U S A. 2010 Jul 6; 107(27):12329-34. PMID: 20616090; PMCID: PMC2901447.
      8. Otte S, Hasenstaub A, Callaway EM. Cell type-specific control of neuronal responsiveness by gamma-band oscillatory inhibition. J Neurosci. 2010 Feb 10; 30(6):2150-9. PMID: 20147542; PMCID: PMC2824444.
      9. Hasenstaub A, Sachdev RN, McCormick DA. State changes rapidly modulate cortical neuronal responsiveness. J Neurosci. 2007 Sep 5; 27(36):9607-22. PMID: 17804621.
        View in: PubMed
      10. Haider B, Duque A, Hasenstaub AR, Yu Y, McCormick DA. Enhancement of visual responsiveness by spontaneous local network activity in vivo. J Neurophysiol. 2007 Jun; 97(6):4186-202. PMID: 17409168.
        View in: PubMed
      11. Haider B, Duque A, Hasenstaub AR, McCormick DA. Neocortical network activity in vivo is generated through a dynamic balance of excitation and inhibition. J Neurosci. 2006 Apr 26; 26(17):4535-45. PMID: 16641233.
        View in: PubMed
      12. Shu Y, Hasenstaub A, Duque A, Yu Y, McCormick DA. Modulation of intracortical synaptic potentials by presynaptic somatic membrane potential. Nature. 2006 Jun 8; 441(7094):761-5. PMID: 16625207.
        View in: PubMed
      13. Hasenstaub A, Shu Y, Haider B, Kraushaar U, Duque A, McCormick DA. Inhibitory postsynaptic potentials carry synchronized frequency information in active cortical networks. Neuron. 2005 Aug 4; 47(3):423-35. PMID: 16055065.
        View in: PubMed
      14. Shu Y, Hasenstaub A, Badoual M, Bal T, McCormick DA. Barrages of synaptic activity control the gain and sensitivity of cortical neurons. J Neurosci. 2003 Nov 12; 23(32):10388-401. PMID: 14614098.
        View in: PubMed
      15. McCormick DA, Shu Y, Hasenstaub A, Sanchez-Vives M, Badoual M, Bal T. Persistent cortical activity: mechanisms of generation and effects on neuronal excitability. Cereb Cortex. 2003 Nov; 13(11):1219-31. PMID: 14576213.
        View in: PubMed
      16. Shu Y, Hasenstaub A, McCormick DA. Turning on and off recurrent balanced cortical activity. Nature. 2003 May 15; 423(6937):288-93. PMID: 12748642.
        View in: PubMed
      17. Allman J, Hasenstaub A. Brains, maturation times, and parenting. Neurobiol Aging. 1999 Jul-Aug; 20(4):447-54. PMID: 10604439.
        View in: PubMed
      18. Allman J, Rosin A, Kumar R, Hasenstaub A. Parenting and survival in anthropoid primates: caretakers live longer. Proc Natl Acad Sci U S A. 1998 Jun 9; 95(12):6866-9. PMID: 9618504; PMCID: PMC22663.
      Andrea's Networks
      Related Concepts
      Derived automatically from this person's publications.
      People in Profiles who have published with this person.
      Related Authors
      People who share related concepts with this person.
      Back to TOP