Andy Chang, PhD
|School||UCSF School of Medicine|
|Department||Cardiovascular Research Inst|
|Address||555 Mission Bay Blvd South|
San Francisco CA 94158
|Harvard University||A.B.||2000||Biochemical Sciences|
|University of California, San Francisco||Ph.D.||2006||Cell Biology (Tetrad)|
|The Rockefeller University||Postdoc||2008||Neuroscience|
|Stanford University School of Medicine||Postdoc||2016||Biochemistry|
|Harvard University||2000||A.B., magna cum laude in Biochemical Sciences|
|National Science Foundation||2001
||2004||Graduate Research Fellowship|
||2011||K12 Career Development Program|
|Helen Hay Whitney Foundation||2009
To maintain optimal oxygen delivery to tissues, there is constant regulation of respiratory and cardiovascular systems by mechanisms that act on different time scales. On a fast time scale, a small chemosensory organ called the carotid body senses decreases in blood oxygen to increase breathing within seconds. The carotid body can also regulate cardiovascular function acutely, and carotid body hyperactivity contributes to disease progression in hypertension, heart failure, and metabolic syndrome. Using the mouse as our primary model, we aim to identify the molecular mechanisms that mediate the carotid body’s ability to detect changes in blood oxygen as well as other metabolic signals, such as carbon dioxide and acid. One long term goal is to apply this knowledge to manipulating carotid body activity in the treatment of cardiovascular disease and metabolic syndrome.
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