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    Andy Chang, PhD

    Address555 Mission Bay Blvd South
    San Francisco CA 94158
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      Collapse Biography 
      Collapse Education and Training
      Harvard UniversityA.B.Biochemical Sciences2000
      University of California, San FranciscoPh.D.Cell Biology (Tetrad)2006
      The Rockefeller UniversityPostdocNeuroscience2008
      Stanford University School of MedicinePostdocBiochemistry2016
      Collapse Awards and Honors
      Harvard University2000A.B., magna cum laude in Biochemical Sciences
      National Science Foundation2001 - 2004Graduate Research Fellowship
      NHLBI2008 - 2011K12 Career Development Program
      Helen Hay Whitney Foundation2009 - 2012Postdoctoral Fellowship

      Collapse Overview 
      Collapse Overview
      To maintain optimal oxygen delivery to tissues, there is constant regulation of respiratory and cardiovascular systems by mechanisms that act on different time scales. On a fast time scale, a small chemosensory organ called the carotid body senses decreases in blood oxygen to increase breathing within seconds. The carotid body can also regulate cardiovascular function acutely, and carotid body hyperactivity contributes to disease progression in hypertension, heart failure, and metabolic syndrome. Using the mouse as our primary model, we aim to identify the molecular mechanisms that mediate the carotid body’s ability to detect changes in blood oxygen as well as other metabolic signals, such as carbon dioxide and acid. One long term goal is to apply this knowledge to manipulating carotid body activity in the treatment of cardiovascular disease and metabolic syndrome.

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      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Chang AJ, Ortega FE, Riegler J, Madison DV, Krasnow MA. Oxygen regulation of breathing through an olfactory receptor activated by lactate. Nature. 2015 Nov 12; 527(7577):240-4. PMID: 26560302.
        View in: PubMed
      2. Zimmer M, Gray JM, Pokala N, Chang AJ, Karow DS, Marletta MA, Hudson ML, Morton DB, Chronis N, Bargmann CI. Neurons detect increases and decreases in oxygen levels using distinct guanylate cyclases. Neuron. 2009 Mar 26; 61(6):865-79. PMID: 19323996; PMCID: PMC2760494.
      3. Chang AJ, Bargmann CI. Hypoxia and the HIF-1 transcriptional pathway reorganize a neuronal circuit for oxygen-dependent behavior in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2008 May 20; 105(20):7321-6. PMID: 18477695; PMCID: PMC2438248.
      4. Chang AJ, Chronis N, Karow DS, Marletta MA, Bargmann CI. A distributed chemosensory circuit for oxygen preference in C. elegans. PLoS Biol. 2006 Sep; 4(9):e274. PMID: 16903785; PMCID: PMC1540710.
      5. Gray JM, Karow DS, Lu H, Chang AJ, Chang JS, Ellis RE, Marletta MA, Bargmann CI. Oxygen sensation and social feeding mediated by a C. elegans guanylate cyclase homologue. Nature. 2004 Jul 15; 430(6997):317-22. PMID: 15220933.
        View in: PubMed
      6. Chang AJ, Morisato D. Regulation of Easter activity is required for shaping the Dorsal gradient in the Drosophila embryo. Development. 2002 Dec; 129(24):5635-45. PMID: 12421704.
        View in: PubMed
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