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Anil Sapru, MD

TitleAssociate Prof In Residence
SchoolUCSF School of Medicine
DepartmentPediatrics
Address550 16th Street
San Francisco CA 94158
Phone415-476-0963
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoSpecial Study2005 Medicine (Advance Training in Clinical Research)

    Collapse Research 
    Collapse Research Activities and Funding
    Collaborative Research to Validate Biomarkers of Pediatric ARDS
    NIH/NICHD UG1HD083166Dec 24, 2014 - Nov 30, 2019
    Role: Co-Principal Investigator
    Coagulation and Fibrinolysis in Pediatric Insulin Titration Trial
    NIH/NHLBI R01HL114484Aug 1, 2012 - Jul 31, 2017
    Role: Principal Investigator
    Targeted Genomic Analysis of Coagulation Pathways in Acute Lung Injury
    NIH/NHLBI K23HL085526Aug 1, 2007 - Jan 31, 2014
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse Clinical Trials
    Collapse Global Health

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Langelier C, Zinter MS, Kalantar K, Yanik GA, Christenson S, O'Donovan B, White C, Wilson M, Sapru A, Dvorak CC, Miller S, Chiu CY, DeRisi JL. Metagenomic Sequencing Detects Respiratory Pathogens in Hematopoietic Cellular Transplant Patients. Am J Respir Crit Care Med. 2017 Jul 07. PMID: 28686513.
      View in: PubMed
    2. Zinter MS, Orwoll BE, Spicer AC, Alkhouli MF, Calfee CS, Matthay MA, Sapru A. Incorporating Inflammation into Mortality Risk in Pediatric Acute Respiratory Distress Syndrome. Crit Care Med. 2017 Feb 28. PMID: 28248715.
      View in: PubMed
    3. Fitzgerald JC, Basu RK, Akcan-Arikan A, Izquierdo LM, Piñeres Olave BE, Hassinger AB, Szczepanska M, Deep A, Williams D, Sapru A, Roy JA, Nadkarni VM, Thomas NJ, Weiss SL, Furth S. Acute Kidney Injury in Pediatric Severe Sepsis: An Independent Risk Factor for Death and New Disability. Crit Care Med. 2016 Dec; 44(12):2241-2250. PMID: 27513354.
      View in: PubMed
    4. Ward SL, Quinn CM, Valentine SL, Sapru A, Curley MA, Willson DF, Liu KD, Matthay MA, Flori HR. Poor Adherence to Lung-Protective Mechanical Ventilation in Pediatric Acute Respiratory Distress Syndrome. Pediatr Crit Care Med. 2016 Oct; 17(10):917-923. PMID: 27513687.
      View in: PubMed
    5. Spicer AC, Calfee CS, Zinter MS, Khemani RG, Lo VP, Alkhouli MF, Orwoll BE, Graciano AL, Boriosi JP, Howard JP, Flori HR, Matthay MA, Sapru A, et al. A Simple and Robust Bedside Model for Mortality Risk in Pediatric Patients With Acute Respiratory Distress Syndrome. Pediatr Crit Care Med. 2016 Aug 3. PMID: 27487912.
      View in: PubMed
    6. Orwoll BE, Sapru A. Biomarkers in Pediatric ARDS: Future Directions. Front Pediatr. 2016; 4:55. PMID: 27313995.
      View in: PubMed
    7. Sapru A, Liu KD, Wiemels J, Hansen H, Pawlikowska L, Poon A, Jorgenson E, Witte JS, Calfee CS, Ware LB, Matthay MA. Association of common genetic variation in the protein C pathway genes with clinical outcomes in acute respiratory distress syndrome. Crit Care. 2016; 20(1):151. PMID: 27215212.
      View in: PubMed
    8. Moreira A, Sapru A, Rimensberger PC. What's new about circulating biomarkers in pediatric acute lung disease. Intensive Care Med. 2016 May; 42(5):803-5. PMID: 26969672.
      View in: PubMed
    9. Orwoll BE, Spicer AC, Zinter MS, Alkhouli MF, Khemani RG, Flori HR, Neuhaus JM, Calfee CS, Matthay MA, Sapru A. Elevated soluble thrombomodulin is associated with organ failure and mortality in children with acute respiratory distress syndrome (ARDS): a prospective observational cohort study. Crit Care. 2015; 19(1):435. PMID: 26652251.
      View in: PubMed
    10. Zinter MS, Spicer A, Orwoll BO, Alkhouli M, Dvorak CC, Calfee CS, Matthay MA, Sapru A. Plasma angiopoietin-2 outperforms other markers of endothelial injury in prognosticating pediatric ARDS mortality. Am J Physiol Lung Cell Mol Physiol. 2016 Feb 1; 310(3):L224-31. PMID: 26660787.
      View in: PubMed
    11. Zinter MS, Dvorak CC, Spicer A, Cowan MJ, Sapru A. New Insights Into Multicenter PICU Mortality Among Pediatric Hematopoietic Stem Cell Transplant Patients. Crit Care Med. 2015 Sep; 43(9):1986-94. PMID: 26035280.
      View in: PubMed
    12. Pediatric acute respiratory distress syndrome: consensus recommendations from the Pediatric Acute Lung Injury Consensus Conference. Pediatr Crit Care Med. 2015 Jun; 16(5):428-39. PMID: 25647235.
      View in: PubMed
    13. Sapru A, Flori H, Quasney MW, Dahmer MK. Pathobiology of acute respiratory distress syndrome. Pediatr Crit Care Med. 2015 Jun; 16(5 Suppl 1):S6-22. PMID: 26035365.
      View in: PubMed
    14. Flori H, Dahmer MK, Sapru A, Quasney MW. Comorbidities and assessment of severity of pediatric acute respiratory distress syndrome: proceedings from the Pediatric Acute Lung Injury Consensus Conference. Pediatr Crit Care Med. 2015 Jun; 16(5 Suppl 1):S41-50. PMID: 26035363.
      View in: PubMed
    15. Wellnitz K, Harris IS, Sapru A, Fineman JR, Radman M. Longitudinal development of obesity in the post-Fontan population. Eur J Clin Nutr. 2015 Oct; 69(10):1105-8. PMID: 25920422.
      View in: PubMed
    16. Sapru A, Calfee CS, Liu KD, Kangelaris K, Hansen H, Pawlikowska L, Ware LB, Alkhouli MF, Abbot J, Matthay MA. Plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome. Intensive Care Med. 2015 Mar; 41(3):470-8. PMID: 25643902; PMCID: PMC4500527 [Available on 03/01/16].
    17. Zinter MS, DuBois SG, Spicer A, Matthay K, Sapru A. Pediatric cancer type predicts infection rate, need for critical care intervention, and mortality in the pediatric intensive care unit. Intensive Care Med. 2014 Oct; 40(10):1536-44. PMID: 25023526; PMCID: PMC4177269.
    18. Valentine S, Sapru A, Randolph A. The authors reply. Crit Care Med. 2013 May; 41(5):e49. PMID: 23591230.
      View in: PubMed
    19. Valentine SL, Sapru A, Higgerson RA, Spinella PC, Flori HR, Graham DA, Brett M, Convery M, Christie LM, Karamessinis L, Randolph AG. Fluid balance in critically ill children with acute lung injury. Crit Care Med. 2012 Oct; 40(10):2883-9. PMID: 22824936; PMCID: PMC3455114.
    20. Khush KK, Pawlikowska L, Menza RL, Goldstein BA, Hayden V, Nguyen J, Kim H, Poon A, Sapru A, Matthay MA, Kwok PY, Young WL, Baxter-Lowe LA, Zaroff JG. Beta-adrenergic receptor polymorphisms and cardiac graft function in potential organ donors. Am J Transplant. 2012 Dec; 12(12):3377-86. PMID: 22994654; PMCID: PMC3513582.
    21. Sapru A, Zaroff JG, Pawlikowska L, Liu KD, Khush KK, Baxter-Lowe LA, Hayden V, Menza RL, Convery M, Lo V, Poon A, Kim H, Young WL, Kukreja J, Matthay MA. The 4G/4G genotype of the PAI-1 (serpine-1) 4G/5G polymorphism is associated with decreased lung allograft utilization. Am J Transplant. 2012 Jul; 12(7):1848-54. PMID: 22390401; PMCID: PMC4018219.
    22. Boriosi JP, Cohen RA, Summers E, Sapru A, Hanson JH, Gildengorin G, Newman V, Flori HR. Lung aeration changes after lung recruitment in children with acute lung injury: a feasibility study. Pediatr Pulmonol. 2012 Aug; 47(8):771-9. PMID: 22298419; PMCID: PMC4169705.
    23. Kangelaris KN, Sapru A, Calfee CS, Liu KD, Pawlikowska L, Witte JS, Vittinghoff E, Zhuo H, Auerbach AD, Ziv E, Matthay MA. The association between a Darc gene polymorphism and clinical outcomes in African American patients with acute lung injury. Chest. 2012 May; 141(5):1160-9. PMID: 22207676; PMCID: PMC3342784.
    24. Anagnostopoulos PV, Johnson NC, Robertson L, Sapru A, Azakie A. Surgical management of left ventricular outflow tract obstruction. J Card Surg. 2012 Jan; 27(1):103-11. PMID: 22150843.
      View in: PubMed
    25. Boriosi JP, Sapru A, Hanson JH, Asselin J, Gildengorin G, Newman V, Sabato K, Flori HR. Efficacy and safety of lung recruitment in pediatric patients with acute lung injury. Pediatr Crit Care Med. 2011 Jul; 12(4):431-6. PMID: 21057351; PMCID: PMC4127306.
    26. Azakie A, Lavrsen MJ, Johnson NC, Sapru A. Early outcomes of primary sutureless repair of the pulmonary veins. Ann Thorac Surg. 2011 Aug; 92(2):666-71; discussion 671-2. PMID: 21704970.
      View in: PubMed
    27. Shinkawa T, Anagnostopoulos PV, Johnson NC, Presnell L, Watanabe N, Sapru A, Azakie A. Early results of the "clamp and sew" Fontan procedure without the use of circulatory support. Ann Thorac Surg. 2011 May; 91(5):1453-9. PMID: 21524454.
      View in: PubMed
    28. Azakie A, Johnson NC, Anagnostopoulos PV, Akram SM, McQuillen P, Sapru A. Stage II palliation of hypoplastic left heart syndrome without cardiopulmonary bypass. J Thorac Cardiovasc Surg. 2011 Feb; 141(2):400-6. PMID: 21241860.
      View in: PubMed
    29. Sapru A, Pawlikowska L, Liu KD, Khush KK, Ann-Baxter-Lowe L, Hayden V, Menza RL, Convery M, Poon A, Landeck M, Zaroff JG, Matthay MA. Single-nucleotide polymorphisms in the ß-adrenergic receptor genes are associated with lung allograft utilization. J Heart Lung Transplant. 2011 Feb; 30(2):211-7. PMID: 20869266; PMCID: PMC3019270.
    30. Azakie A, Johnson NC, Anagnostopoulos PV, Egrie GD, Lavrsen MJ, Sapru A. Cardiac surgery in low birth weight infants: current outcomes. Interact Cardiovasc Thorac Surg. 2011 Mar; 12(3):409-13, discussion 414. PMID: 21106568.
      View in: PubMed
    31. Shinkawa T, Anagnostopoulos PV, Johnson NC, Watanabe N, Sapru A, Azakie A. Performance of bovine pericardial valves in the pulmonary position. Ann Thorac Surg. 2010 Oct; 90(4):1295-300. PMID: 20868832.
      View in: PubMed
    32. Sapru A, Curley MA, Brady S, Matthay MA, Flori H. Elevated PAI-1 is associated with poor clinical outcomes in pediatric patients with acute lung injury. Intensive Care Med. 2010 Jan; 36(1):157-63. PMID: 19855955; PMCID: PMC2807603.
    33. Wu S, Sapru A, Stewart MA, Milet MJ, Hudes M, Livermore LF, Flori HR. Using acupuncture for acute pain in hospitalized children. Pediatr Crit Care Med. 2009 May; 10(3):291-6. PMID: 19307808; PMCID: PMC4127308.
    34. Sapru A, Hansen H, Ajayi T, Brown R, Garcia O, Zhuo H, Wiemels J, Matthay MA, Wiener-Kronish J. 4G/5G polymorphism of plasminogen activator inhibitor-1 gene is associated with mortality in intensive care unit patients with severe pneumonia. Anesthesiology. 2009 May; 110(5):1086-91. PMID: 19387177; PMCID: PMC4127307.
    35. Hirsch J, Niemann CU, Hansen KC, Choi S, Su X, Frank JA, Fang X, Hirose R, Theodore P, Sapru A, Burlingame AL, Matthay MA. Alterations in the proteome of pulmonary alveolar type II cells in the rat after hepatic ischemia-reperfusion. Crit Care Med. 2008 Jun; 36(6):1846-54. PMID: 18496381; PMCID: PMC2442403.
    36. Hirsch J, Hansen KC, Sapru A, Frank JA, Chalkley RJ, Fang X, Trinidad JC, Baker P, Burlingame AL, Matthay MA. Impact of low and high tidal volumes on the rat alveolar epithelial type II cell proteome. Am J Respir Crit Care Med. 2007 May 15; 175(10):1006-13. PMID: 17363773; PMCID: PMC1899270.
    37. Sapru A, Wiemels JL, Witte JS, Ware LB, Matthay MA. Acute lung injury and the coagulation pathway: Potential role of gene polymorphisms in the protein C and fibrinolytic pathways. Intensive Care Med. 2006 Sep; 32(9):1293-303. PMID: 16770611.
      View in: PubMed
    38. Shih CY, Sapru A, Oishi P, Azakie A, Karl TR, Harmon C, Asija R, Adatia I, Fineman JR. Alterations in plasma B-type natriuretic peptide levels after repair of congenital heart defects: a potential perioperative marker. J Thorac Cardiovasc Surg. 2006 Mar; 131(3):632-8. PMID: 16515916.
      View in: PubMed
    39. Cepkova M, Brady S, Sapru A, Matthay MA, Church G. Biological markers of lung injury before and after the institution of positive pressure ventilation in patients with acute lung injury. Crit Care. 2006; 10(5):R126. PMID: 16956410; PMCID: PMC1751077.
    40. Sapru A, Gitelman SE, Bhatia S, Dubin RF, Newman TB, Flori H. Prevalence and characteristics of type 2 diabetes mellitus in 9-18 year-old children with diabetic ketoacidosis. J Pediatr Endocrinol Metab. 2005 Sep; 18(9):865-72. PMID: 16279364.
      View in: PubMed
    41. Azakie A, Martinez D, Sapru A, Fineman J, Teitel D, Karl TR. Impact of right ventricle to pulmonary artery conduit on outcome of the modified Norwood procedure. Ann Thorac Surg. 2004 May; 77(5):1727-33. PMID: 15111174.
      View in: PubMed
    42. Subramanyan R, Joy J, Venugopalan P, Sapru A, al Khusaiby SM. Incidence and spectrum of congenital heart disease in Oman. Ann Trop Paediatr. 2000 Dec; 20(4):337-41. PMID: 11219172.
      View in: PubMed
    43. Kronn DF, Sapru A, Satou GM. Management of hypercholesterolemia in childhood and adolescence. Heart Dis. 2000 Sep-Oct; 2(5):348-53. PMID: 11728281.
      View in: PubMed
    44. Joy MV, Venugopalan P, Sapru A, Subramanyan R. Isolated hypoplasia of right ventricle with atrial septal defect: a rare form of cyanotic heart disease. Indian Heart J. 1999 Jul-Aug; 51(4):440-3. PMID: 10547948.
      View in: PubMed
    45. Sapru A, bin Seif Ali Elbualy M, Nayyar PM. Esophageal foreign body causing recurrent respiratory symptoms. Gastrointest Endosc. 1998 Aug; 48(2):218-9. PMID: 9717796.
      View in: PubMed
    46. Mallari RQ, Saif M, Elbualy MS, Sapru A. Ingestion of a blister beetle (Mecoidae family). Pediatrics. 1996 Sep; 98(3 Pt 1):458-9. PMID: 8784376.
      View in: PubMed
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