Ann Zovein, MD

Address555 Mission Bay Blvd South
San Francisco CA 94158
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    Collapse Biography 
    Collapse education and training
    Boston UniversityB.S. Biomedical Engineering1995College of Engineering
    Boston University School of MedicineM.D.1999School of Medicine
    University of California, Los AngelesResidency 2002Pediatrics
    University of California, Los AngelesFellowship2006Division of Neonatology
    University of California, Los AngelesPostdoctoral Fellowship2010Molecular, Cell and Developmental Biology

    Collapse Research 
    Collapse Research Activities and Funding
    Engineering human endothelium for hematopoietic stem cell production
    NIH/NHLBI DP2HL117743Sep 30, 2012 - Aug 31, 2017
    Role: Principal Investigator
    Engineering human endothelium for hematopoietic stem cell production
    NIH/NHLBI DP2HL117743Sep 30, 2012 - Aug 31, 2017
    Role: Principal Investigator
    Engineering human endothelium for hematopoietic stem cell production
    NIH/NHLBI DP2HL117743Sep 30, 2012 - Aug 31, 2017
    Role: Principal Investigator

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    Collapse In The News
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    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Selected Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Ponder KL, Bárcena A, Bos FL, Gormley M, Zhou Y, Ona K, Kapidzic M, Zovein A, Fisher SJ. Preeclampsia and Inflammatory Preterm Labor Alter the Human Placental Hematopoietic Niche. Reprod Sci. 2016 Mar 3. PMID: 26944948.
      View in: PubMed
    2. Lizama CO, Hawkins JS, Schmitt CE, Bos FL, Zape JP, Cautivo KM, Borges Pinto H, Rhyner AM, Yu H, Donohoe ME, Wythe JD, Zovein AC. Repression of arterial genes in hemogenic endothelium is sufficient for haematopoietic fate acquisition. Nat Commun. 2015; 6:7739. PMID: 26204127; PMCID: PMC4519987.
    3. Zovein AC, Forsberg EC. Hematopoietic development at high altitude: blood stem cells put to the test. Development. 2015 May 15; 142(10):1728-32. PMID: 25968308.
      View in: PubMed
    4. Koh FM, Lizama CO, Wong P, Hawkins JS, Zovein AC, Ramalho-Santos M. Emergence of hematopoietic stem and progenitor cells involves a Chd1-dependent increase in total nascent transcription. Proc Natl Acad Sci U S A. 2015 Apr 7; 112(14):E1734-43. PMID: 25831528; PMCID: PMC4394284.
    5. Schmitt CE, Lizama CO, Zovein AC. From transplantation to transgenics: mouse models of developmental hematopoiesis. Exp Hematol. 2014 Aug; 42(8):707-16. PMID: 25014737.
      View in: PubMed
    6. Lizama CO, Zovein AC. Polarizing pathways: balancing endothelial polarity, permeability, and lumen formation. Exp Cell Res. 2013 May 15; 319(9):1247-54. PMID: 23567183; PMCID: PMC3686563.
    7. Cristofaro B, Shi Y, Faria M, Suchting S, Leroyer AS, Trindade A, Duarte A, Zovein AC, Iruela-Arispe ML, Nih LR, Kubis N, Henrion D, Loufrani L, Todiras M, Schleifenbaum J, Gollasch M, Zhuang ZW, Simons M, Eichmann A, le Noble F. Dll4-Notch signaling determines the formation of native arterial collateral networks and arterial function in mouse ischemia models. Development. 2013 Apr; 140(8):1720-9. PMID: 23533173; PMCID: PMC4074271.
    8. Hofmann JJ, Briot A, Enciso J, Zovein AC, Ren S, Zhang ZW, Radtke F, Simons M, Wang Y, Iruela-Arispe ML. Endothelial deletion of murine Jag1 leads to valve calcification and congenital heart defects associated with Alagille syndrome. Development. 2012 Dec 1; 139(23):4449-60. PMID: 23095891; PMCID: PMC3509736.
    9. Zape JP, Zovein AC. Hemogenic endothelium: origins, regulation, and implications for vascular biology. Semin Cell Dev Biol. 2011 Dec; 22(9):1036-47. PMID: 22001113.
      View in: PubMed
    10. Hofmann JJ, Zovein AC, Koh H, Radtke F, Weinmaster G, Iruela-Arispe ML. Jagged1 in the portal vein mesenchyme regulates intrahepatic bile duct development: insights into Alagille syndrome. Development. 2010 Dec; 137(23):4061-72. PMID: 21062863; PMCID: PMC2976287.
    11. Zovein AC, Turlo KA, Ponec RM, Lynch MR, Chen KC, Hofmann JJ, Cox TC, Gasson JC, Iruela-Arispe ML. Vascular remodeling of the vitelline artery initiates extravascular emergence of hematopoietic clusters. Blood. 2010 Nov 4; 116(18):3435-44. PMID: 20699440.
      View in: PubMed
    12. Zovein AC, Luque A, Turlo KA, Hofmann JJ, Yee KM, Becker MS, Fassler R, Mellman I, Lane TF, Iruela-Arispe ML. Beta1 integrin establishes endothelial cell polarity and arteriolar lumen formation via a Par3-dependent mechanism. Dev Cell. 2010 Jan 19; 18(1):39-51. PMID: 20152176; PMCID: PMC3178410.
    13. Zovein AC, Iruela-Arispe ML. Time to cut the cord: placental HSCs grow up. Cell Stem Cell. 2009 Oct 2; 5(4):351-2. PMID: 19796613.
      View in: PubMed
    14. Zovein AC, Hofmann JJ, Lynch M, French WJ, Turlo KA, Yang Y, Becker MS, Zanetta L, Dejana E, Gasson JC, Tallquist MD, Iruela-Arispe ML. Fate tracing reveals the endothelial origin of hematopoietic stem cells. Cell Stem Cell. 2008 Dec 4; 3(6):625-36. PMID: 19041779; PMCID: PMC2631552.
    15. Monvoisin A, Alva JA, Hofmann JJ, Zovein AC, Lane TF, Iruela-Arispe ML. VE-cadherin-CreERT2 transgenic mouse: a model for inducible recombination in the endothelium. Dev Dyn. 2006 Dec; 235(12):3413-22. PMID: 17072878.
      View in: PubMed
    16. Zovein AC, Iruela-Arispe ML. My O'Myeloid, a tale of two lineages. Proc Natl Acad Sci U S A. 2006 Aug 29; 103(35):12959-60. PMID: 16924095; PMCID: PMC1559733.
    17. Alva JA, Zovein AC, Monvoisin A, Murphy T, Salazar A, Harvey NL, Carmeliet P, Iruela-Arispe ML. VE-Cadherin-Cre-recombinase transgenic mouse: a tool for lineage analysis and gene deletion in endothelial cells. Dev Dyn. 2006 Mar; 235(3):759-67. PMID: 16450386.
      View in: PubMed
    18. Zovein A, Flowers-Ziegler J, Thamotharan S, Shin D, Sankar R, Nguyen K, Gambhir S, Devaskar SU. Postnatal hypoxic-ischemic brain injury alters mechanisms mediating neuronal glucose transport. Am J Physiol Regul Integr Comp Physiol. 2004 Feb; 286(2):R273-82. PMID: 14525722.
      View in: PubMed
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