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    Anna Orr, PhD

    TitleAssistant Professor
    SchoolUCSF School of Medicine
    DepartmentNeurology
    Address1650 Owens St
    San Francisco CA 94107
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      Collapse Biography 
      Collapse Education and Training
      The J. David Gladstone InstitutesStaff ScientistGladstone Institute of Neurological Disease2016
      The J. David Gladstone InstitutesResearch ScientistGladstone Institute of Neurological Disease2014
      The J. David Gladstone Institutes and UCSFPostdoctoral fellowGladstone Institute of Neurological Disease and the Department of Neurology2013
      Emory University, Atlanta, GAPh.D.Neuroscience Graduate Program2008
      Allegheny College, Meadville, PAB.S.Neuroscience, Psychology (Magna cum laude)2002
      Collapse Awards and Honors
      The J. David Gladstone Institutes2015Alan Kaganov Scholar
      Alzheimer's Disease Research Center, UCSF2015Resource Allocation Program Pilot Grant for Junior Investigators
      National Institute on Aging (NIA/NIH)2014K99 Pathway to Independence Career Award
      National Institute on Aging (NIA/NIH)2011F32 National Research Service Award
      National Institute of Neurological Disorders and Stroke (NINDS/NIH)2006F31 National Research Service Award
      Society for Neuroscience2013Postdoctoral Fellow Travel Award
      Society for Neuroscience2005Graduate Student Travel Award

      Collapse Overview 
      Collapse Overview
      Our goal is to understand the roles of glial cells in CNS health and disease. In particular, we investigate how receptor signaling in astrocytes and microglia affects cognitive function and neurodegeneration. Insights gained from our exploratory and preclinical studies are used to better understand the causes of disease and help develop new therapies for neurological disorders.

      Dr. Orr received her bachelor’s degree in Neuroscience and Psychology from Allegheny College in 2002 and earned her Ph.D. in Neuroscience from Emory University in 2008. She completed postdoctoral training at the Gladstone Institute of Neurological Disease in 2013. Her research has been supported by the National Institutes of Health, the Alzheimer’s Disease Research Center at UCSF, and the Alan Kaganov Scholarship. She is a recipient of the K99/R00 Pathway to Independence Career Award from the National Institute on Aging and currently a Staff Scientist at the Gladstone Institute of Neurological Disease and Assistant Adjunct Professor at UCSF.

      Collapse Interests
      Neurobiology, neurological disorders, astrocytes, microglia, glial-neuronal interactions, G protein-coupled receptors, cellular signal transduction, learning and memory, aging-related cognitive decline.

      Collapse ORNG Applications 
      Collapse Websites
      Collapse In The News
      Collapse Featured Publications

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Orr AG, Hsiao EC, Wang MM, Ho K, Kim DH, Wang X, Guo W, Kang J, Yu GQ, Adame A, Devidze N, Dubal DB, Masliah E, Conklin BR, Mucke L. Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory. Nat Neurosci. 2015 Mar; 18(3):423-34. PMID: 25622143; PMCID: PMC4340760.
      2. Sanchez PE, Zhu L, Verret L, Vossel KA, Orr AG, Cirrito JR, Devidze N, Ho K, Yu GQ, Palop JJ, Mucke L. Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model. Proc Natl Acad Sci U S A. 2012 Oct 16; 109(42):E2895-903. PMID: 22869752; PMCID: PMC3479491.
      3. Cissé M, Halabisky B, Harris J, Devidze N, Dubal DB, Sun B, Orr A, Lotz G, Kim DH, Hamto P, Ho K, Yu GQ, Mucke L. Reversing EphB2 depletion rescues cognitive functions in Alzheimer model. Nature. 2011 Jan 6; 469(7328):47-52. PMID: 21113149; PMCID: PMC3030448.
      4. Mullasseril P, Hansen KB, Vance KM, Ogden KK, Yuan H, Kurtkaya NL, Santangelo R, Orr AG, Le P, Vellano KM, Liotta DC, Traynelis SF. A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors. Nat Commun. 2010; 1:90. PMID: 20981015; PMCID: PMC3113701.
      5. Hansen KB, Mullasseril P, Dawit S, Kurtkaya NL, Yuan H, Vance KM, Orr AG, Kvist T, Ogden KK, Le P, Vellano KM, Lewis I, Kurtkaya S, Du Y, Qui M, Murphy TJ, Snyder JP, Bräuner-Osborne H, Traynelis SF. Implementation of a fluorescence-based screening assay identifies histamine H3 receptor antagonists clobenpropit and iodophenpropit as subunit-selective N-methyl-D-aspartate receptor antagonists. J Pharmacol Exp Ther. 2010 Jun; 333(3):650-62. PMID: 20197375; PMCID: PMC2879924.
      6. Gyoneva S, Orr AG, Traynelis SF. Differential regulation of microglial motility by ATP/ADP and adenosine. Parkinsonism Relat Disord. 2009 Dec; 15 Suppl 3:S195-9. PMID: 20082989.
        View in: PubMed
      7. Orr AG, Sharma A, Binder NB, Miller AH, Pearce BD. Interleukin-1 mediates long-term hippocampal dentate granule cell loss following postnatal viral infection. J Mol Neurosci. 2010 May; 41(1):89-96. PMID: 19774496.
        View in: PubMed
      8. Orr AG, Orr AL, Li XJ, Gross RE, Traynelis SF. Adenosine A(2A) receptor mediates microglial process retraction. Nat Neurosci. 2009 Jul; 12(7):872-8. PMID: 19525944; PMCID: PMC2712729.
      9. Mannaioni G, Orr AG, Hamill CE, Yuan H, Pedone KH, McCoy KL, Berlinguer Palmini R, Junge CE, Lee CJ, Yepes M, Hepler JR, Traynelis SF. Plasmin potentiates synaptic N-methyl-D-aspartate receptor function in hippocampal neurons through activation of protease-activated receptor-1. J Biol Chem. 2008 Jul 18; 283(29):20600-11. PMID: 18474593; PMCID: PMC2459301.
      10. Nicole O, Goldshmidt A, Hamill CE, Sorensen SD, Sastre A, Lyuboslavsky P, Hepler JR, McKeon RJ, Traynelis SF. Activation of protease-activated receptor-1 triggers astrogliosis after brain injury. J Neurosci. 2005 Apr 27; 25(17):4319-29. PMID: 15858058.
        View in: PubMed
      11. Hamill CE, Goldshmidt A, Nicole O, McKeon RJ, Brat DJ, Traynelis SF. Special lecture: glial reactivity after damage: implications for scar formation and neuronal recovery. Clin Neurosurg. 2005; 52:29-44. PMID: 16626052.
        View in: PubMed
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