 Anthony Shum, MD
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| Title | Assistant Professor in Residence |
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| School | UCSF School of Medicine |
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| Department | Medicine |
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| Address | 513 Parnassus Ave
San Francisco CA 94143
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| Phone | 415-502-0273 |
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 Biography | The Foundation of the American Thoracic Society | 2012
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| 2014 | Defining the Molecular Basis of Interstitial Lung Disease in Rheumatoid Arthritis | | University of California | 2012
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| 2013 | A Biomarker for Autoimmune-mediated Interstitial Lung Disease | | NIH/NHLBI | 2010
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| 2014 | Antigen Identification in a Novel Model of Lung Autoimmunity | | National Organization of Rare Disease | 2010
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| 2012 | Novel Translational Biomarkers in the Diagnosis and Management of APS1 | | American Thoracic Society | 2007
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| 2008 | American Thoracic Society Career Development Award | | Will Rogers Institute | 2005
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| 2006 | Will Rogers Institute Fellowship |
Overview The Shum Lab (http://shumlab.ucsf.edu) is located on the UCSF Parnassus campus on HSE13 and performs research designed to understand the pathogenesis of autoimmune-mediated lung disease by:
1) defining the specificity of the immune response in patients with lung autoreactivity
2) uncovering the genetic underpinnings of autoimmune lung disease using next generation sequencing
3) defining effector mechanisms of lung autoreactivity in animal models
By directly enrolling human subjects into our research program we perform studies that provide us with novel insights we can use to design animal models to dissect basic mechanisms of autoimmune-mediated lung disease. Through this research we hope to discover diagnostic and interventional targets that will ultimately enable us to develop biomarkers and therapies that will directly impact patient care.
Bibliographic
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Lee JS, Kim EJ, Lynch KL, Elicker B, Ryerson CJ, Katsumoto TR, Shum AK, Wolters PJ, Cerri S, Richeldi L, Jones KD, King TE, Collard HR. Prevalence and clinical significance of circulating autoantibodies in idiopathic pulmonary fibrosis. Respir Med. 2013 Feb; 107(2):249-55.
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Su MA, Davini D, Cheng P, Giang K, Fan U, DeVoss JJ, Johannes KP, Taylor L, Shum AK, Valenzise M, Meloni A, Bour-Jordan H, Anderson MS. Defective autoimmune regulator-dependent central tolerance to myelin protein zero is linked to autoimmune peripheral neuropathy. J Immunol. 2012 May 15; 188(10):4906-12.
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Shum AK, DeVoss J, Tan CL, Hou Y, Johannes K, O'Gorman CS, Jones KD, Sochett EB, Fong L, Anderson MS. Identification of an autoantigen demonstrates a link between interstitial lung disease and a defect in central tolerance. Sci Transl Med. 2009 Dec 2; 1(9):9ra20.
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Chen H, Gomez A, Shum A, Collard HR. Longitudinal lung function in idiopathic NSIP: what are we missing? Eur Respir J. 2009 Oct; 34(4):1004; author reply 1004-5.
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Devoss JJ, Shum AK, Johannes KP, Lu W, Krawisz AK, Wang P, Yang T, Leclair NP, Austin C, Strauss EC, Anderson MS. Effector mechanisms of the autoimmune syndrome in the murine model of autoimmune polyglandular syndrome type 1. J Immunol. 2008 Sep 15; 181(6):4072-9.
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Zhang L, Barker JM, Babu S, Su M, Stenerson M, Cheng M, Shum A, Zamir E, Badolato R, Law A, Eisenbarth GS, Anderson MS. A robust immunoassay for anti-interferon autoantibodies that is highly specific for patients with autoimmune polyglandular syndrome type 1. Clin Immunol. 2007 Nov; 125(2):131-7.
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Cheng MH, Shum AK, Anderson MS. What's new in the Aire? Trends Immunol. 2007 Jul; 28(7):321-7.
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Davis JL, Shum AK, Huang L. A 36-year-old man with AIDS and relapsing, nonproductive cough. Chest. 2007 Jun; 131(6):1929-31.
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