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    Arthur Wallace, MD, PhD

    TitleProfessor
    SchoolUCSF School of Medicine
    DepartmentAnesthesia
    Address4150 Clement St
    San Francisco CA 94121
    Phone415-210-6077
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      Collapse Biography 
      Collapse Education and Training
      University of California, San FranciscoResidency School of Medicine

      Collapse Overview 
      Collapse Overview
      Art Wallace, M.D., Ph.D. is a professor and vice-chair of anesthesiology and perioperative care at the University of California, San Francisco and Chief of the Anesthesia Service at the Veterans Affairs Medical Center in San Francisco. His clinical practice includes cardiac and non-cardiac anesthesiology as well as ICU and preoperative clinical care. He completed a B.S. in engineering and applied science with a specialty in electrical engineering at Yale. He then completed an M.D. and Ph.D. at Johns Hopkins Medical School with his Ph.D. in biomedical engineering with research in systems physiology and autonomic control of the vasculature. He then moved to the University of California, San Francisco where he completed an internship in internal medicine, a residency in anesthesiology, and a cardiac anesthesiology fellowship. His research at UCSF has included numerous projects in animals and patients including device development for monitoring, surgical therapy of heart failure, and the off pump CABG, as well as drug development and testing. He is best known for his work developing medications for the prevention of perioperative cardiac morbidity and mortality. He was one of the developers of perioperative beta blockade and has assisted more than 200 hospitals set up perioperative beta blocker programs. His present work includes development medications to reduce perioperative cardiac risk, development of the ECOM cardiac output monitor, developing a non-invasive respiratory monitor, a device to provide electronic sedation, testing and development of surgical therapies for heart failure, implementation of perioperative beta blockade, developing therapies to prevent perioperative and ICU related PTSD, and developing computer systems to improve systems based medicine. He lectures extensively on cardiac risk reduction and has produced an on-line course on cardiac risk reduction. intelligence.

      Collapse Interests
      Cardiac Anesthesia, Biomedical Engineering, Medical Device Design, Clinical Informatics, Perioperative Beta Blockade, Cardiac Risk Reduction, Systems Based Medicine, Big Data, Epidemiology, Outcomes Research

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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Wallace AW. Sevoflurane Contamination: Water Accumulation in Sevoflurane Vaporizers Can Allow Bacterial Growth in the Vaporizer. A A Case Rep. 2016 Jun 15; 6(12):399-401. PMID: 27301057.
        View in: PubMed
      2. Ge L, Wu Y, Soleimani M, Khazalpour M, Takaba K, Tartibi M, Zhang Z, Acevedo-Bolton G, Saloner DA, Wallace AW, Mishra R, Grossi EA, Guccione JM, Ratcliffe MB. Moderate Ischemic Mitral Regurgitation After Posterolateral Myocardial Infarction in Sheep Alters Left Ventricular Shear but Not Normal Strain in the Infarct and Infarct Borderzone. Ann Thorac Surg. 2016 May; 101(5):1691-9. PMID: 26857634.
        View in: PubMed
      3. Lee SM, Takemoto S, Wallace AW. In Reply. Anesthesiology. 2016 Feb; 124(2):513-4. PMID: 26785436.
        View in: PubMed
      4. Lee SM, Takemoto S, Wallace AW. Association between Withholding Angiotensin Receptor Blockers in the Early Postoperative Period and 30-day Mortality: A Cohort Study of the Veterans Affairs Healthcare System. Anesthesiology. 2015 Aug; 123(2):288-306. PMID: 26200181.
        View in: PubMed
      5. Mudumbai SC, Wagner T, Mahajan S, King R, Heidenreich PA, Hlatky M, Wallace AW, Mariano ER. Effectiveness of preoperative beta-blockade on intra-operative heart rate in vascular surgery cases conducted under regional or local anesthesia. Springerplus. 2014; 3:227. PMID: 24855591; PMCID: PMC4024108.
      6. Mudumbai SC, Takemoto S, Cason BA, Au S, Upadhyay A, Wallace AW. Thirty-day mortality risk associated with the postoperative nonresumption of angiotensin-converting enzyme inhibitors: a retrospective study of the Veterans Affairs Healthcare System. J Hosp Med. 2014 May; 9(5):289-96. PMID: 24799360.
        View in: PubMed
      7. Shimkunas R, Zhang Z, Wenk JF, Soleimani M, Khazalpour M, Acevedo-Bolton G, Wang G, Saloner D, Mishra R, Wallace AW, Ge L, Baker AJ, Guccione JM, Ratcliffe MB. Left ventricular myocardial contractility is depressed in the borderzone after posterolateral myocardial infarction. Ann Thorac Surg. 2013 May; 95(5):1619-25. PMID: 23523189; PMCID: PMC3640420.
      8. Acevedo-Bolton G, Suzuki T, Malhotra D, Zhang Z, Wallace AW, Guccione JM, Saloner DA, Ratcliffe MB. Left ventricular pressure gating in ovine cardiac studies: a software-based method. J Biomech Eng. 2013 Mar 1; 135(3):34502. PMID: 24231818; PMCID: PMC3705966.
      9. Wallace AW. Risk of acute myocardial infarction in patients with total hip or knee replacement: comment on "Timing of acute myocardial infarction in patients undergoing total hip or knee replacement: a nationwide cohort study". Arch Intern Med. 2012 Sep 10; 172(16):1235-6. PMID: 22825029.
        View in: PubMed
      10. Zhang Z, Sun K, Saloner DA, Wallace AW, Ge L, Baker AJ, Guccione JM, Ratcliffe MB. The benefit of enhanced contractility in the infarct borderzone: a virtual experiment. Front Physiol. 2012; 3:86. PMID: 22509168; PMCID: PMC3321638.
      11. Wenk JF, Ge L, Zhang Z, Soleimani M, Potter DD, Wallace AW, Tseng E, Ratcliffe MB, Guccione JM. A coupled biventricular finite element and lumped-parameter circulatory system model of heart failure. Comput Methods Biomech Biomed Engin. 2013; 16(8):807-18. PMID: 22248290; PMCID: PMC3367128.
      12. Wong VM, Wenk JF, Zhang Z, Cheng G, Acevedo-Bolton G, Burger M, Saloner DA, Wallace AW, Guccione JM, Ratcliffe MB, Ge L. The effect of mitral annuloplasty shape in ischemic mitral regurgitation: a finite element simulation. Ann Thorac Surg. 2012 Mar; 93(3):776-82. PMID: 22245588; PMCID: PMC3432639.
      13. Soleimani M, Khazalpour M, Cheng G, Zhang Z, Acevedo-Bolton G, Saloner DA, Mishra R, Wallace AW, Guccione JM, Ge L, Ratcliffe MB. Moderate mitral regurgitation accelerates left ventricular remodeling after posterolateral myocardial infarction. Ann Thorac Surg. 2011 Nov; 92(5):1614-20. PMID: 21945222; PMCID: PMC3253877.
      14. Lee LC, Wenk JF, Klepach D, Zhang Z, Saloner D, Wallace AW, Ge L, Ratcliffe MB, Guccione JM. A novel method for quantifying in-vivo regional left ventricular myocardial contractility in the border zone of a myocardial infarction. J Biomech Eng. 2011 Sep; 133(9):094506. PMID: 22010752; PMCID: PMC3207355.
      15. Wallace AW, Au S, Cason BA. Perioperative ß-blockade: atenolol is associated with reduced mortality when compared to metoprolol. Anesthesiology. 2011 Apr; 114(4):824-36. PMID: 21372680.
        View in: PubMed
      16. Wenk JF, Sun K, Zhang Z, Soleimani M, Ge L, Saloner D, Wallace AW, Ratcliffe MB, Guccione JM. Regional left ventricular myocardial contractility and stress in a finite element model of posterobasal myocardial infarction. J Biomech Eng. 2011 Apr; 133(4):044501. PMID: 21428685; PMCID: PMC3097530.
      17. Zhang Z, Tendulkar A, Sun K, Saloner DA, Wallace AW, Ge L, Guccione JM, Ratcliffe MB. Comparison of the Young-Laplace law and finite element based calculation of ventricular wall stress: implications for postinfarct and surgical ventricular remodeling. Ann Thorac Surg. 2011 Jan; 91(1):150-6. PMID: 21172505; PMCID: PMC3058250.
      18. Wallace AW, Au S, Cason BA. Association of the pattern of use of perioperative ß-blockade and postoperative mortality. Anesthesiology. 2010 Oct; 113(4):794-805. PMID: 20864832.
        View in: PubMed
      19. Wenk JF, Zhang Z, Cheng G, Malhotra D, Acevedo-Bolton G, Burger M, Suzuki T, Saloner DA, Wallace AW, Guccione JM, Ratcliffe MB. First finite element model of the left ventricle with mitral valve: insights into ischemic mitral regurgitation. Ann Thorac Surg. 2010 May; 89(5):1546-53. PMID: 20417775; PMCID: PMC2887313.
      20. Sun K, Zhang Z, Suzuki T, Wenk JF, Stander N, Einstein DR, Saloner DA, Wallace AW, Guccione JM, Ratcliffe MB. Dor procedure for dyskinetic anteroapical myocardial infarction fails to improve contractility in the border zone. J Thorac Cardiovasc Surg. 2010 Jul; 140(1):233-9, 239.e1-4. PMID: 20299030; PMCID: PMC2907919.
      21. Sun K, Stander N, Jhun CS, Zhang Z, Suzuki T, Wang GY, Saeed M, Wallace AW, Tseng EE, Baker AJ, Saloner D, Einstein DR, Ratcliffe MB, Guccione JM. A computationally efficient formal optimization of regional myocardial contractility in a sheep with left ventricular aneurysm. J Biomech Eng. 2009 Nov; 131(11):111001. PMID: 20016753.
        View in: PubMed
      22. Walker JC, Ratcliffe MB, Zhang P, Wallace AW, Hsu EW, Saloner DA, Guccione JM. Magnetic resonance imaging-based finite element stress analysis after linear repair of left ventricular aneurysm. J Thorac Cardiovasc Surg. 2008 May; 135(5):1094-102, 1102.e1-2. PMID: 18455590; PMCID: PMC3773224.
      23. Zhang P, Guccione JM, Nicholas SI, Walker JC, Crawford PC, Shamal A, Acevedo-Bolton G, Guttman MA, Ozturk C, McVeigh ER, Saloner DA, Wallace AW, Ratcliffe MB. Endoventricular patch plasty for dyskinetic anteroapical left ventricular aneurysm increases systolic circumferential shortening in sheep. J Thorac Cardiovasc Surg. 2007 Oct; 134(4):1017-24. PMID: 17903523; PMCID: PMC2615826.
      24. Wallace AW. Clonidine and modification of perioperative outcome. Curr Opin Anaesthesiol. 2006 Aug; 19(4):411-7. PMID: 16829723.
        View in: PubMed
      25. Guccione JM, Walker JC, Beitler JR, Moonly SM, Zhang P, Guttman MA, Ozturk C, McVeigh ER, Wallace AW, Saloner DA, Ratcliffe MB. The effect of anteroapical aneurysm plication on end-systolic three-dimensional strain in the sheep: a magnetic resonance imaging tagging study. J Thorac Cardiovasc Surg. 2006 Mar; 131(3):579-586.e3. PMID: 16515908; PMCID: PMC1482534.
      26. Zhang P, Guccione JM, Nicholas SI, Walker JC, Crawford PC, Shamal A, Saloner DA, Wallace AW, Ratcliffe MB. Left ventricular volume and function after endoventricular patch plasty for dyskinetic anteroapical left ventricular aneurysm in sheep. J Thorac Cardiovasc Surg. 2005 Oct; 130(4):1032-8. PMID: 16214516; PMCID: PMC1475735.
      27. Walker JC, Ratcliffe MB, Zhang P, Wallace AW, Fata B, Hsu EW, Saloner D, Guccione JM. MRI-based finite-element analysis of left ventricular aneurysm. Am J Physiol Heart Circ Physiol. 2005 Aug; 289(2):H692-700. PMID: 15778283.
        View in: PubMed
      28. Walker JC, Guccione JM, Jiang Y, Zhang P, Wallace AW, Hsu EW, Ratcliffe MB. Helical myofiber orientation after myocardial infarction and left ventricular surgical restoration in sheep. J Thorac Cardiovasc Surg. 2005 Feb; 129(2):382-90. PMID: 15678050.
        View in: PubMed
      29. Dang AB, Guccione JM, Zhang P, Wallace AW, Gorman RC, Gorman JH, Ratcliffe MB. Effect of ventricular size and patch stiffness in surgical anterior ventricular restoration: a finite element model study. Ann Thorac Surg. 2005 Jan; 79(1):185-93. PMID: 15620941.
        View in: PubMed
      30. Dang AB, Guccione JM, Mishell JM, Zhang P, Wallace AW, Gorman RC, Gorman JH, Ratcliffe MB. Akinetic myocardial infarcts must contain contracting myocytes: finite-element model study. Am J Physiol Heart Circ Physiol. 2005 Apr; 288(4):H1844-50. PMID: 15604126.
        View in: PubMed
      31. Wallace AW, Galindez D, Salahieh A, Layug EL, Lazo EA, Haratonik KA, Boisvert DM, Kardatzke D. Effect of clonidine on cardiovascular morbidity and mortality after noncardiac surgery. Anesthesiology. 2004 Aug; 101(2):284-93. PMID: 15277909.
        View in: PubMed
      32. Wallace AW. Is it time to get on the fast track or stay on the slow track? Anesthesiology. 2003 Oct; 99(4):774. PMID: 14508304.
        View in: PubMed
      33. Guccione JM, Salahieh A, Moonly SM, Kortsmit J, Wallace AW, Ratcliffe MB. Myosplint decreases wall stress without depressing function in the failing heart: a finite element model study. Ann Thorac Surg. 2003 Oct; 76(4):1171-80; discussion 1180. PMID: 14530007.
        View in: PubMed
      34. Quarterman RL, Moonly S, Wallace AW, Guccione J, Ratcliffe MB. A finite element model of left ventricular cellular transplantation in dilated cardiomyopathy. ASAIO J. 2002 Sep-Oct; 48(5):508-13. PMID: 12296571.
        View in: PubMed
      35. Victal OA, Teerlink JR, Gaxiola E, Wallace AW, Najar S, Camacho DH, Gutierrez A, Herrera G, Zuniga G, Mercado-Rios F, Ratcliffe MB. Left ventricular volume reduction by radiofrequency heating of chronic myocardial infarction in patients with congestive heart failure. Circulation. 2002 Mar 19; 105(11):1317-22. PMID: 11901042.
        View in: PubMed
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