Shoshana Zha • UCSF Profiles

Shoshana Zha, MD, PhD

Title(s)	Assistant Professor, Medicine
School	School of Medicine
Address	505 Parnassus Avenue, #635 San Francisco CA 94117
Phone	--
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Overview

Dr. Zha is a Pulmonary and Critical Care physician scientist. She specializes in the care of patients with bronchiectasis and nontuberculous mycobacterial pulmonary infections. She cofounded the Bronchiectasis and Pulmonary NTM Clinic at UCSF and attends in the Parnassus intensive care units. In addition, Dr. Zha conducts basic science research that focuses on understanding the innate immune response to mycobacterial infections.

Interests

Tuberculosis, Nontuberculous mycobacterium, Bronchiectasis, Health Equity, Innate Immunity

Global Health Equity

Research

Research Activities and Funding

Diversity and function of mononuclear phagocytes in the lung driven by mycobacterium tuberculosis infection
NHLBI 1K08HL163405Apr 30, 2022 - Apr 30, 2027
Role: Principal Investigator
Description: Project Narrative Mycobacterium tuberculosis (MTB) causes over a million deaths worldwide each year. Despite decades of research, basic understanding of the early interaction of the bacteria and the immune system remains lacking which has impeded treatment options and a lasting effective vaccine. This project aims to describe in detail the immune cells involved in early infection, and which subtypes allow for MTB to grow most effectively, providing direct targets for therapeutic development.

Describing the innate immune response of mycobacterium tuberculosis at a single-cell resolution
NIH F32HL159403May 1, 2021 - Apr 30, 2022
Role: Principal Investigator

Mechanisms of HIV Protease Inhibitor-Induced Lipid Dysregulation in Adipocytes
NIH F30DK085856Sep 25, 2009 - Sep 24, 2013
Role: Principal Investigator

ORNG Applications

Clinical Trials

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

Altmetrics Details

PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Systematic functional interrogation of SARS-CoV-2 host factors using Perturb-seq. Nat Commun. 2023 10 06; 14(1):6245. Sunshine S, Puschnik AS, Replogle JM, Laurie MT, Liu J, Zha BS, Nuñez JK, Byrum JR, McMorrow AH, Frieman MB, Winkler J, Qiu X, Rosenberg OS, Leonetti MD, Ye CJ, Weissman JS, DeRisi JL, Hein MY. PMID: 37803001; PMCID: PMC10558542.

View in: PubMed Mentions: 2 Fields:
Bio Biology Sci Science
Translation:Humans Cells
A myeloid program associated with COVID-19 severity is decreased by therapeutic blockade of IL-6 signaling. iScience. 2023 Oct 20; 26(10):107813. Hackney JA, Shivram H, Vander Heiden J, Overall C, Orozco L, Gao X, Kim E, West N, Qamra A, Chang D, Chakrabarti A, Choy DF, Combes AJ, Courau T, Fragiadakis GK, Rao AA, Ray A, Tsui J, Hu K, Kuhn NF, Krummel MF, Erle DJ, Kangelaris K, Sarma A, Lyon Z, Calfee CS, Woodruff PG, Ghale R, Mick E, Byrne A, Zha BS, Langelier C, Hendrickson CM, van der Wijst MGP, Hartoularos GC, Grant T, Bueno R, Lee DS, Greenland JR, Sun Y, Perez R, Ogorodnikov A, Ward A, Ye CJ, UCSF COMET Consortium, Ramalingam T, McBride JM, Cai F, Teterina A, Bao M, Tsai L, Rosas IO, Regev A, Kapadia SB, Bauer RN, Rosenberger CM. PMID: 37810211; PMCID: PMC10551843.

View in: PubMed Mentions: 1
Mycobacterium tuberculosis resides in lysosome-poor monocyte-derived lung cells during chronic infection. Res Sq. 2023 Jun 15. Zheng W, Chang IC, Limberis J, Budzik J, Zha BS, Howard Z, Chen L, Ernst J. PMID: 37398178; PMCID: PMC10312915.

View in: PubMed Mentions:
Mycobacterium tuberculosis resides in lysosome-poor monocyte-derived lung cells during chronic infection. bioRxiv. 2023 May 28. Zheng W, Chang IC, Limberis J, Budzik JM, Zha BS, Howard Z, Chen L, Ernst JD. PMID: 36711606; PMCID: PMC9882350.

View in: PubMed Mentions: 1
Bacterial Strain-Dependent Dissociation of Cell Recruitment and Cell-to-Cell Spread in Early M. tuberculosis Infection. mBio. 2022 06 28; 13(3):e0133222. Zha BS, Desvignes L, Fergus TJ, Cornelius A, Cheng TY, Moody DB, Ernst JD. PMID: 35695454; PMCID: PMC9239178.

View in: PubMed Mentions: 3 Fields:
Mic Microbiology
Translation:Animals Cells
Impaired immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19. medRxiv. 2021 Nov 30. Tsitsiklis A, Zha BS, Byrne A, DeVoe C, Rackaityte E, Levan S, Sunshine S, Mick E, Ghale R, Love C, Tarashansky AJ, Pisco A, Albright J, Jauregui A, Sarma A, Neff N, Serpa PH, Deiss TJ, Kistler A, Carrillo S, Ansel KM, Leligdowicz A, Christenson S, Detweiler A, Jones NG, Wu B, Darmanis S, Lynch SV, DeRisi JL, COMET Consortium, Matthay MA, Hendrickson CM, Kangelaris KN, Krummel MF, Woodruff PG, Erle DJ, Rosenberg O, Calfee CS, Langelier CR. PMID: 33791731; PMCID: PMC8010763.

View in: PubMed Mentions: 1
Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS. Nat Commun. 2021 08 26; 12(1):5152. Sarma A, Christenson SA, Byrne A, Mick E, Pisco AO, DeVoe C, Deiss T, Ghale R, Zha BS, Tsitsiklis A, Jauregui A, Moazed F, Detweiler AM, Spottiswoode N, Sinha P, Neff N, Tan M, Serpa PH, Willmore A, Ansel KM, Wilson JG, Leligdowicz A, Siegel ER, Sirota M, DeRisi JL, Matthay MA, COMET Consortium, Hendrickson CM, Kangelaris KN, Krummel MF, Woodruff PG, Erle DJ, Calfee CS, Langelier CR. PMID: 34446707; PMCID: PMC8390461.

View in: PubMed Mentions: 25 Fields:
Bio Biology Sci Science
Translation:Humans Cells
Impaired immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19. Res Sq. 2021 Apr 23. Tsitsiklis A, Zha BS, Byrne A, Devoe C, Levan S, Rackaityte E, Sunshine S, Mick E, Ghale R, Jauregui A, Sarma A, Neff N, Serpa PH, Deiss TJ, Kistler A, Carrillo S, Ansel KM, Leligdowicz A, Christenson S, Jones N, Wu B, Darmanis S, Matthay MA, Lynch SV, DeRisi JL, COMET Consortium, Hendrickson CM, Kangelaris KN, Krummel MF, Woodruff PG, Erle DJ, Rosenberg O, Calfee CS, Langelier CR. PMID: 34013247; PMCID: PMC8132240.

View in: PubMed Mentions:
COVID-19 ARDS is characterized by a dysregulated host response that differs from cytokine storm and is modified by dexamethasone. Res Sq. 2021 Jan 14. Sarma A, Christenson SA, Mick E, DeVoe C, Deiss T, Pisco AO, Ghale R, Jauregui A, Byrne A, Moazed F, Spottiswoode N, Sinha P, Zha BS, Neff N, Tan M, Serpa PH, Ansel KM, Wilson JG, Leligdowicz A, Siegel ER, Sirota M, DeRisi JL, Matthay MA, COMET Consortium, Hendrickson CM, Kangelaris KN, Krummel MF, Woodruff PG, Erle DJ, Calfee CS, Langelier CR. PMID: 33469573; PMCID: PMC7814832.

View in: PubMed Mentions: 3
An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike. Science. 2020 12 18; 370(6523):1473-1479. Schoof M, Faust B, Saunders RA, Sangwan S, Rezelj V, Hoppe N, Boone M, Billesbølle CB, Puchades C, Azumaya CM, Kratochvil HT, Zimanyi M, Deshpande I, Liang J, Dickinson S, Nguyen HC, Chio CM, Merz GE, Thompson MC, Diwanji D, Schaefer K, Anand AA, Dobzinski N, Zha BS, Simoneau CR, Leon K, White KM, Chio US, Gupta M, Jin M, Li F, Liu Y, Zhang K, Bulkley D, Sun M, Smith AM, Rizo AN, Moss F, Brilot AF, Pourmal S, Trenker R, Pospiech T, Gupta S, Barsi-Rhyne B, Belyy V, Barile-Hill AW, Nock S, Liu Y, Krogan NJ, Ralston CY, Swaney DL, García-Sastre A, Ott M, Vignuzzi M, QCRG Structural Biology Consortium, Walter P, Manglik A. PMID: 33154106; PMCID: PMC7857409.

View in: PubMed Mentions: 209 Fields:
Sci Science
Translation:Humans Animals Cells
Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2. Nat Chem Biol. 2021 01; 17(1):113-121. Bracken CJ, Lim SA, Solomon P, Rettko NJ, Nguyen DP, Zha BS, Schaefer K, Byrnes JR, Zhou J, Lui I, Liu J, Pance K, QCRG Structural Biology Consortium, Zhou XX, Leung KK, Wells JA. PMID: 33082574; PMCID: PMC8356808.

View in: PubMed Mentions: 49 Fields:
Bio Biology Che Chemistry
Translation:Humans Animals Cells
Summary for Clinicians: 2020 Clinical Practice Guideline Summary for the Treatment of Nontuberculous Mycobacterial Pulmonary Disease. Ann Am Thorac Soc. 2020 09; 17(9):1033-1039. Kurz SG, Zha BS, Herman DD, Holt MR, Daley CL, Ruminjo JK, Thomson CC. PMID: 32870060.

View in: PubMed Mentions: 9 Fields:
Pul Pulmonary Medicine
Translation:Humans
Treatment of Drug-Susceptible Tuberculosis. Clin Chest Med. 2019 12; 40(4):763-774. Zha BS, Nahid P. PMID: 31731983.

View in: PubMed Mentions: 10 Fields:
Pul Pulmonary Medicine
Translation:Humans
Difficult to Identify: Malignant Primary Peritoneal Mesothelioma. Am J Med. 2015 Nov; 128(11):1191-4. Zha BS, Flanagan M, Coulson C, Garvin KW. PMID: 26164565.

View in: PubMed Mentions: 4 Fields:
Med Medicine (General)
Translation:Humans
HIV protease inhibitors disrupt lipid metabolism by activating endoplasmic reticulum stress and inhibiting autophagy activity in adipocytes. PLoS One. 2013; 8(3):e59514. Zha BS, Wan X, Zhang X, Zha W, Zhou J, Wabitsch M, Wang G, Lyall V, Hylemon PB, Zhou H. PMID: 23533630; PMCID: PMC3606318.

View in: PubMed Mentions: 40 Fields:
Med Medicine (General)Sci Science
Translation:Humans Animals Cells
Inhibition of P-glycoprotein by HIV protease inhibitors increases intracellular accumulation of berberine in murine and human macrophages. PLoS One. 2013; 8(1):e54349. Zha W, Wang G, Xu W, Liu X, Wang Y, Zha BS, Shi J, Zhao Q, Gerk PM, Studer E, Hylemon PB, Pandak WM, Zhou H. PMID: 23372711; PMCID: PMC3553168.

View in: PubMed Mentions: 12 Fields:
Med Medicine (General)Sci Science
Translation:Humans Animals Cells
The cellular pharmacokinetics of HIV protease inhibitors: current knowledge and future perspectives. Curr Drug Metab. 2012 Oct; 13(8):1174-83. Zha W, Zha BS, Zhou F, Zhou H, Wang G. PMID: 22746305.

View in: PubMed Mentions: 5 Fields:
Che Chemistry Met Metabolism
Translation:Humans Animals Cells
ER Stress and Lipid Metabolism in Adipocytes. Biochem Res Int. 2012; 2012:312943. Zha BS, Zhou H. PMID: 22400114; PMCID: PMC3287011.

View in: PubMed Mentions: 28
Cellular pharmacokinetic mechanisms of adriamycin resistance and its modulation by 20(S)-ginsenoside Rh2 in MCF-7/Adr cells. Br J Pharmacol. 2012 Jan; 165(1):120-34. Zhang J, Zhou F, Wu X, Zhang X, Chen Y, Zha BS, Niu F, Lu M, Hao G, Sun Y, Sun J, Peng Y, Wang G. PMID: 21615726; PMCID: PMC3252972.

View in: PubMed Mentions: 31 Fields:
Pha Pharmacology
Translation:Humans Cells