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Bin Liu, PhD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentAnesthesia
Address1001 Potrero Ave, SFGH 1
San Francisco CA 94110
Phone415-206-6973
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    Collapse Biography 
    Collapse education and training
    University of California, San FranciscoPostdoctoral StudiesGraduate Division

    Collapse Research 
    Collapse Research Activities and Funding
    Internalizing human antibody-targeted nanosized siRNA therapeutics
    NIH/NCI R01CA171315Aug 6, 2012 - Jul 31, 2017
    Role: Principal Investigator
    Identifying antigens bound by novel scFvs targeting all subtypes of mesothelioma
    NIH/NCI R01CA129491Mar 1, 2010 - Dec 31, 2014
    Role: Principal Investigator
    Selection of internalizing human antibodies targeting pancreatic tumor cells in s
    NIH/NCI R21CA137429Feb 1, 2009 - Jan 31, 2012
    Role: Principal Investigator
    Internalizing antibody-targeted nanosized siRNA therapeutics
    NIH/NCI R21CA135586Dec 5, 2008 - Nov 30, 2011
    Role: Principal Investigator
    Mapping a clinically significant internalizing tumor epitope space
    NIH/NCI R01CA118919Mar 7, 2006 - Mar 31, 2014
    Role: Principal Investigator
    Tumor specific cell sruface epitope- molecular evolution
    NIH/NIDDK R21DK066429Feb 1, 2004 - Jan 31, 2007
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Selected Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Bidlingmaier S, Ha K, Lee NK, Su Y, Liu B. Proteome-wide Identification of Novel Ceramide-binding Proteins by Yeast Surface cDNA Display and Deep Sequencing. Mol Cell Proteomics. 2016 Apr; 15(4):1232-45. PMID: 26729710.
      View in: PubMed
    2. Sherbenou DW, Behrens CR, Su Y, Wolf JL, Martin TG, Liu B. The development of potential antibody-based therapies for myeloma. Blood Rev. 2015 Mar; 29(2):81-91. PMID: 25294123; PMCID: PMC4482758.
    3. Ha KD, Bidlingmaier SM, Zhang Y, Su Y, Liu B. High-content analysis of antibody phage-display library selection outputs identifies tumor selective macropinocytosis-dependent rapidly internalizing antibodies. Mol Cell Proteomics. 2014 Dec; 13(12):3320-31. PMID: 25149096; PMCID: PMC4256486.
    4. Behrens CR, Liu B. Methods for site-specific drug conjugation to antibodies. MAbs. 2014 Jan-Feb; 6(1):46-53. PMID: 24135651; PMCID: PMC3929454.
    5. Federman N, Chan J, Nagy JO, Landaw EM, McCabe K, Wu AM, Triche T, Kang H, Liu B, Marks JD, Denny CT. Enhanced growth inhibition of osteosarcoma by cytotoxic polymerized liposomal nanoparticles targeting the alcam cell surface receptor. Sarcoma. 2012; 2012:126906. PMID: 23024593; PMCID: PMC3447386.
    6. McCabe KE, Liu B, Marks JD, Tomlinson JS, Wu H, Wu AM. An engineered cysteine-modified diabody for imaging activated leukocyte cell adhesion molecule (ALCAM)-positive tumors. Mol Imaging Biol. 2012 Jun; 14(3):336-47. PMID: 21630083; PMCID: PMC3227780.
    7. Iyer AK, Lan X, Zhu X, Su Y, Feng J, Zhang X, Gao D, Seo Y, Vanbrocklin HF, Broaddus VC, Liu B, He J. Novel human single chain antibody fragments that are rapidly internalizing effectively target epithelioid and sarcomatoid mesotheliomas. Cancer Res. 2011 Apr 1; 71(7):2428-32. PMID: 21447742; PMCID: PMC3071798.
    8. Iyer AK, Su Y, Feng J, Lan X, Zhu X, Liu Y, Gao D, Seo Y, Vanbrocklin HF, Courtney Broaddus V, Liu B, He J. The effect of internalizing human single chain antibody fragment on liposome targeting to epithelioid and sarcomatoid mesothelioma. Biomaterials. 2011 Apr; 32(10):2605-13. PMID: 21255833; PMCID: PMC3040448.
    9. Bidlingmaier S, Liu B. Construction of yeast surface-displayed cDNA libraries. Methods Mol Biol. 2011; 729:199-210. PMID: 21365492; PMCID: PMC3228857.
    10. Bidlingmaier S, Liu B. Identification of protein/target molecule interactions using yeast surface-displayed cDNA libraries. Methods Mol Biol. 2011; 729:211-23. PMID: 21365493; PMCID: PMC3229213.
    11. Bidlingmaier S, Wang Y, Liu Y, Zhang N, Liu B. Comprehensive analysis of yeast surface displayed cDNA library selection outputs by exon microarray to identify novel protein-ligand interactions. Mol Cell Proteomics. 2011 Mar; 10(3):M110.005116. PMID: 21127146; PMCID: PMC3047160.
    12. Chen Y, Zhu X, Zhang X, Liu B, Huang L. Nanoparticles modified with tumor-targeting scFv deliver siRNA and miRNA for cancer therapy. Mol Ther. 2010 Sep; 18(9):1650-6. PMID: 20606648; PMCID: PMC2956922.
    13. Zhu X, Bidlingmaier S, Hashizume R, James CD, Berger MS, Liu B. Identification of internalizing human single-chain antibodies targeting brain tumor sphere cells. Mol Cancer Ther. 2010 Jul; 9(7):2131-41. PMID: 20587664; PMCID: PMC2944778.
    14. He J, Wang Y, Feng J, Zhu X, Lan X, Iyer AK, Zhang N, Seo Y, VanBrocklin HF, Liu B. Targeting prostate cancer cells in vivo using a rapidly internalizing novel human single-chain antibody fragment. J Nucl Med. 2010 Mar; 51(3):427-32. PMID: 20150269; PMCID: PMC2832590.
    15. Drummond DC, Noble CO, Guo Z, Hayes ME, Connolly-Ingram C, Gabriel BS, Hann B, Liu B, Park JW, Hong K, Benz CC, Marks JD, Kirpotin DB. Development of a highly stable and targetable nanoliposomal formulation of topotecan. J Control Release. 2010 Jan 4; 141(1):13-21. PMID: 19686789.
      View in: PubMed
    16. Conrad F, Zhu X, Zhang X, Chalkley RJ, Burlingame AL, Marks JD, Liu B. Human antibodies targeting cell surface antigens overexpressed by the hormone refractory metastatic prostate cancer cells: ICAM-1 is a tumor antigen that mediates prostate cancer cell invasion. J Mol Med (Berl). 2009 May; 87(5):507-14. PMID: 19219419; PMCID: PMC2796542.
    17. Bidlingmaier S, He J, Wang Y, An F, Feng J, Barbone D, Gao D, Franc B, Broaddus VC, Liu B. Identification of MCAM/CD146 as the target antigen of a human monoclonal antibody that recognizes both epithelioid and sarcomatoid types of mesothelioma. Cancer Res. 2009 Feb 15; 69(4):1570-7. PMID: 19221091; PMCID: PMC2752656.
    18. Bidlingmaier S, Zhu X, Liu B. The utility and limitations of glycosylated human CD133 epitopes in defining cancer stem cells. J Mol Med (Berl). 2008 Sep; 86(9):1025-32. PMID: 18535813; PMCID: PMC2585385.
    19. An F, Drummond DC, Wilson S, Kirpotin DB, Nishimura SL, Broaddus VC, Liu B. Targeted drug delivery to mesothelioma cells using functionally selected internalizing human single-chain antibodies. Mol Cancer Ther. 2008 Mar; 7(3):569-78. PMID: 18319332; PMCID: PMC2943512.
    20. Roth A, Drummond DC, Conrad F, Hayes ME, Kirpotin DB, Benz CC, Marks JD, Liu B. Anti-CD166 single chain antibody-mediated intracellular delivery of liposomal drugs to prostate cancer cells. Mol Cancer Ther. 2007 Oct; 6(10):2737-46. PMID: 17938267.
      View in: PubMed
    21. Liu B. Exploring cell type-specific internalizing antibodies for targeted delivery of siRNA. Brief Funct Genomic Proteomic. 2007 Jun; 6(2):112-9. PMID: 17670766.
      View in: PubMed
    22. Bidlingmaier S, Liu B. Interrogating yeast surface-displayed human proteome to identify small molecule-binding proteins. Mol Cell Proteomics. 2007 Nov; 6(11):2012-20. PMID: 17660511.
      View in: PubMed
    23. Liu B, Conrad F, Roth A, Drummond DC, Simko JP, Marks JD. Recombinant full-length human IgG1s targeting hormone-refractory prostate cancer. J Mol Med (Berl). 2007 Oct; 85(10):1113-23. PMID: 17554518.
      View in: PubMed
    24. Goenaga AL, Zhou Y, Legay C, Bougherara H, Huang L, Liu B, Drummond DC, Kirpotin DB, Auclair C, Marks JD, Poul MA. Identification and characterization of tumor antigens by using antibody phage display and intrabody strategies. Mol Immunol. 2007 Jul; 44(15):3777-88. PMID: 17498801; PMCID: PMC2739904.
    25. Ruan W, Sassoon A, An F, Simko JP, Liu B. Identification of clinically significant tumor antigens by selecting phage antibody library on tumor cells in situ using laser capture microdissection. Mol Cell Proteomics. 2006 Dec; 5(12):2364-73. PMID: 16982673.
      View in: PubMed
    26. Bidlingmaier S, Liu B. Construction and application of a yeast surface-displayed human cDNA library to identify post-translational modification-dependent protein-protein interactions. Mol Cell Proteomics. 2006 Mar; 5(3):533-40. PMID: 16321969.
      View in: PubMed
    27. Liu B, Conrad F, Cooperberg MR, Kirpotin DB, Marks JD. Mapping tumor epitope space by direct selection of single-chain Fv antibody libraries on prostate cancer cells. Cancer Res. 2004 Jan 15; 64(2):704-10. PMID: 14744788.
      View in: PubMed
    28. Liu B, Huang L, Sihlbom C, Burlingame A, Marks JD. Towards proteome-wide production of monoclonal antibody by phage display. J Mol Biol. 2002 Feb 1; 315(5):1063-73. PMID: 11827476.
      View in: PubMed
    29. Liu B, Marks JD. Applying phage antibodies to proteomics: selecting single chain Fv antibodies to antigens blotted on nitrocellulose. Anal Biochem. 2000 Nov 1; 286(1):119-28. PMID: 11038282.
      View in: PubMed
    30. Liu B, Alberts BM. Head-on collision between a DNA replication apparatus and RNA polymerase transcription complex. Science. 1995 Feb 24; 267(5201):1131-7. PMID: 7855590.
      View in: PubMed
    31. Liu B, Wong ML, Alberts B. A transcribing RNA polymerase molecule survives DNA replication without aborting its growing RNA chain. Proc Natl Acad Sci U S A. 1994 Oct 25; 91(22):10660-4. PMID: 7524099; PMCID: PMC45081.
    32. Liu B, Wong ML, Tinker RL, Geiduschek EP, Alberts BM. The DNA replication fork can pass RNA polymerase without displacing the nascent transcript. Nature. 1993 Nov 4; 366(6450):33-9. PMID: 8232535.
      View in: PubMed
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