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    Binh Diep, PhD

    TitleAssociate Professor
    SchoolUCSF School of Medicine
    DepartmentMedicine
    Address1001 Potrero Ave
    San Francisco CA 94110
    Phone415-206-3355
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      Collapse Biography 
      Collapse Education and Training
      University of California, San FranciscoPostdocMicrobial Pathogenesis2008
      University of California, BerkeleyPhDInfectious Diseases and Immunity2005
      University of California, BerkeleyB.A.Molecular Cell Biology2000
      Collapse Awards and Honors
      American Society for Microbiology2010ICAAC Young Investigator Award
      Pfizer2009ASPIRE Young Investigator Award

      Collapse ORNG Applications 
      Collapse Websites
      Collapse Awarded Grants

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Cohen TS, Hilliard JJ, Jones-Nelson O, Keller AE, O'Day T, Tkaczyk C, DiGiandomenico A, Hamilton M, Pelletier M, Wang Q, Diep BA, Le VT, Cheng L, Suzich J, Stover CK, Sellman BR. Staphylococcus aureus a toxin potentiates opportunistic bacterial lung infections. Sci Transl Med. 2016 Mar 9; 8(329):329ra31. PMID: 26962155.
        View in: PubMed
      2. Cheung GY, Yeh AJ, Kretschmer D, Duong AC, Tuffuor K, Fu CL, Joo HS, Diep BA, Li M, Nakamura Y, Nunez G, Peschel A, Otto M. Functional characteristics of the Staphylococcus aureus d-toxin allelic variant G10S. Sci Rep. 2015; 5:18023. PMID: 26658455.
        View in: PubMed
      3. Chan LC, Basuino L, Diep B, Hamilton S, Chatterjee SS, Chambers HF. Ceftobiprole- and ceftaroline-resistant methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2015 May; 59(5):2960-3. PMID: 25753637; PMCID: PMC4394828.
      4. Jenkins A, Diep BA, Mai TT, Vo NH, Warrener P, Suzich J, Stover CK, Sellman BR. Differential expression and roles of Staphylococcus aureus virulence determinants during colonization and disease. MBio. 2015; 6(1):e02272-14. PMID: 25691592; PMCID: PMC4337569.
      5. Date SV, Modrusan Z, Lawrence M, Morisaki JH, Toy K, Shah IM, Kim J, Park S, Xu M, Basuino L, Chan L, Zeitschel D, Chambers HF, Tan MW, Brown EJ, Diep BA, Hazenbos WL. Global gene expression of methicillin-resistant Staphylococcus aureus USA300 during human and mouse infection. J Infect Dis. 2014 May 15; 209(10):1542-50. PMID: 24286981.
        View in: PubMed
      6. Diep BA, Phung Q, Date S, Arnott D, Bakalarski C, Xu M, Nakamura G, Swem DL, Alexander MK, Le HN, Mai TT, Tan MW, Brown EJ, Nishiyama M. Identifying potential therapeutic targets of methicillin-resistant Staphylococcus aureus through in vivo proteomic analysis. J Infect Dis. 2014 May 15; 209(10):1533-41. PMID: 24280367; PMCID: PMC3997574.
      7. Hazenbos WL, Kajihara KK, Vandlen R, Morisaki JH, Lehar SM, Kwakkenbos MJ, Beaumont T, Bakker AQ, Phung Q, Swem LR, Ramakrishnan S, Kim J, Xu M, Shah IM, Diep BA, Sai T, Sebrell A, Khalfin Y, Oh A, Koth C, Lin SJ, Lee BC, Strandh M, Koefoed K, Andersen PS, Spits H, Brown EJ, Tan MW, Mariathasan S. Novel staphylococcal glycosyltransferases SdgA and SdgB mediate immunogenicity and protection of virulence-associated cell wall proteins. PLoS Pathog. 2013; 9(10):e1003653. PMID: 24130480; PMCID: PMC3794999.
      8. Le VT, Diep BA. Selected insights from application of whole-genome sequencing for outbreak investigations. Curr Opin Crit Care. 2013 Oct; 19(5):432-9. PMID: 23856896; PMCID: PMC4104273.
      9. Diep BA, Gillet Y, Etienne J, Lina G, Vandenesch F. Panton-Valentine leucocidin and pneumonia. Lancet Infect Dis. 2013 Jul; 13(7):566. PMID: 23809217.
        View in: PubMed
      10. Rasigade JP, Trouillet-Assant S, Ferry T, Diep BA, Sapin A, Lhoste Y, Ranfaing J, Badiou C, Benito Y, Bes M, Couzon F, Tigaud S, Lina G, Etienne J, Vandenesch F, Laurent F. PSMs of hypervirulent Staphylococcus aureus act as intracellular toxins that kill infected osteoblasts. PLoS One. 2013; 8(5):e63176. PMID: 23690994; PMCID: PMC3653922.
      11. Diep BA, Afasizheva A, Le HN, Kajikawa O, Matute-Bello G, Tkaczyk C, Sellman B, Badiou C, Lina G, Chambers HF. Effects of linezolid on suppressing in vivo production of staphylococcal toxins and improving survival outcomes in a rabbit model of methicillin-resistant Staphylococcus aureus necrotizing pneumonia. J Infect Dis. 2013 Jul; 208(1):75-82. PMID: 23532096; PMCID: PMC3666136.
      12. Diep BA. Use of whole-genome sequencing for outbreak investigations. Lancet Infect Dis. 2013 Feb; 13(2):99-101. PMID: 23158673.
        View in: PubMed
      13. Adams-Sapper S, Diep BA, Perdreau-Remington F, Riley LW. Clonal composition and community clustering of drug-susceptible and -resistant Escherichia coli isolates from bloodstream infections. Antimicrob Agents Chemother. 2013 Jan; 57(1):490-7. PMID: 23147723; PMCID: PMC3535975.
      14. Tattevin P, Schwartz BS, Graber CJ, Volinski J, Bhukhen A, Bhukhen A, Mai TT, Vo NH, Dang DN, Phan TH, Basuino L, Perdreau-Remington F, Chambers HF, Diep BA. Concurrent epidemics of skin and soft tissue infection and bloodstream infection due to community-associated methicillin-resistant Staphylococcus aureus. Clin Infect Dis. 2012 Sep; 55(6):781-8. PMID: 22670044; PMCID: PMC3657511.
      15. Diep BA, Equils O, Huang DB, Gladue R. Linezolid effects on bacterial toxin production and host immune response: review of the evidence. Curr Ther Res Clin Exp. 2012 Jun; 73(3):86-102. PMID: 24648596; PMCID: PMC3954010.
      16. Li M, Du X, Villaruz AE, Diep BA, Wang D, Song Y, Tian Y, Hu J, Yu F, Lu Y, Otto M. MRSA epidemic linked to a quickly spreading colonization and virulence determinant. Nat Med. 2012 May; 18(5):816-9. PMID: 22522561; PMCID: PMC3378817.
      17. Adams-Sapper S, Sergeevna-Selezneva J, Tartof S, Raphael E, Diep BA, Perdreau-Remington F, Riley LW. Globally dispersed mobile drug-resistance genes in gram-negative bacterial isolates from patients with bloodstream infections in a US urban general hospital. J Med Microbiol. 2012 Jul; 61(Pt 7):968-74. PMID: 22493279; PMCID: PMC3542709.
      18. Perret M, Badiou C, Lina G, Burbaud S, Benito Y, Bes M, Cottin V, Couzon F, Juruj C, Dauwalder O, Goutagny N, Diep BA, Vandenesch F, Henry T. Cross-talk between Staphylococcus aureus leukocidins-intoxicated macrophages and lung epithelial cells triggers chemokine secretion in an inflammasome-dependent manner. Cell Microbiol. 2012 Jul; 14(7):1019-36. PMID: 22329718.
        View in: PubMed
      19. Malachowa N, Whitney AR, Kobayashi SD, Sturdevant DE, Kennedy AD, Braughton KR, Shabb DW, Diep BA, Chambers HF, Otto M, DeLeo FR. Global changes in Staphylococcus aureus gene expression in human blood. PLoS One. 2011; 6(4):e18617. PMID: 21525981; PMCID: PMC3078114.
      20. Diep BA, Chan L, Tattevin P, Kajikawa O, Martin TR, Basuino L, Mai TT, Marbach H, Braughton KR, Whitney AR, Gardner DJ, Fan X, Tseng CW, Liu GY, Badiou C, Etienne J, Lina G, Matthay MA, DeLeo FR, Chambers HF. Polymorphonuclear leukocytes mediate Staphylococcus aureus Panton-Valentine leukocidin-induced lung inflammation and injury. Proc Natl Acad Sci U S A. 2010 Mar 23; 107(12):5587-92. PMID: 20231457; PMCID: PMC2851770.
      21. Graves SF, Kobayashi SD, Braughton KR, Diep BA, Chambers HF, Otto M, Deleo FR. Relative contribution of Panton-Valentine leukocidin to PMN plasma membrane permeability and lysis caused by USA300 and USA400 culture supernatants. Microbes Infect. 2010 Jun; 12(6):446-56. PMID: 20172045; PMCID: PMC2883622.
      22. Mendes RE, Sader HS, Deshpande LM, Diep BA, Chambers HF, Jones RN. Characterization of baseline methicillin-resistant Staphylococcus aureus isolates recovered from phase IV clinical trial for linezolid. J Clin Microbiol. 2010 Feb; 48(2):568-74. PMID: 19940054; PMCID: PMC2815625.
      23. Tattevin P, Basuino L, Bauer D, Diep BA, Chambers HF. Ceftobiprole is superior to vancomycin, daptomycin, and linezolid for treatment of experimental endocarditis in rabbits caused by methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2010 Feb; 54(2):610-3. PMID: 19917746; PMCID: PMC2812130.
      24. Miragaia M, de Lencastre H, Perdreau-Remington F, Chambers HF, Higashi J, Sullam PM, Lin J, Wong KI, King KA, Otto M, Sensabaugh GF, Diep BA. Genetic diversity of arginine catabolic mobile element in Staphylococcus epidermidis. PLoS One. 2009; 4(11):e7722. PMID: 19893740; PMCID: PMC2768820.
      25. Tseng CW, Kyme P, Low J, Rocha MA, Alsabeh R, Miller LG, Otto M, Arditi M, Diep BA, Nizet V, Doherty TM, Beenhouwer DO, Liu GY. Staphylococcus aureus Panton-Valentine leukocidin contributes to inflammation and muscle tissue injury. PLoS One. 2009; 4(7):e6387. PMID: 19633710; PMCID: PMC2711303.
      26. Tattevin P, Diep BA, Jula M, Perdreau-Remington F. Methicillin-resistant Staphylococcus aureus USA300 clone in long-term care facility. Emerg Infect Dis. 2009 Jun; 15(6):953-5. PMID: 19523301; PMCID: PMC2727319.
      27. Schwartz BS, Graber CJ, Diep BA, Basuino L, Perdreau-Remington F, Chambers HF. Doxycycline, not minocycline, induces its own resistance in multidrug-resistant, community-associated methicillin-resistant Staphylococcus aureus clone USA300. Clin Infect Dis. 2009 May 15; 48(10):1483-4. PMID: 19374563.
        View in: PubMed
      28. Li M, Diep BA, Villaruz AE, Braughton KR, Jiang X, DeLeo FR, Chambers HF, Lu Y, Otto M. Evolution of virulence in epidemic community-associated methicillin-resistant Staphylococcus aureus. Proc Natl Acad Sci U S A. 2009 Apr 7; 106(14):5883-8. PMID: 19293374; PMCID: PMC2667066.
      29. DeLeo FR, Diep BA, Otto M. Host defense and pathogenesis in Staphylococcus aureus infections. Infect Dis Clin North Am. 2009 Mar; 23(1):17-34. PMID: 19135914; PMCID: PMC2748223.
      30. Chambers HF, Basuino L, Diep BA, Steenbergen J, Zhang S, Tattevin P, Alder J. Relationship between susceptibility to daptomycin in vitro and activity in vivo in a rabbit model of aortic valve endocarditis. Antimicrob Agents Chemother. 2009 Apr; 53(4):1463-7. PMID: 19171803; PMCID: PMC2663086.
      31. Tattevin P, Diep BA, Jula M, Perdreau-Remington F. Long-term follow-up of methicillin-resistant Staphylococcus aureus molecular epidemiology after emergence of clone USA300 in San Francisco jail populations. J Clin Microbiol. 2008 Dec; 46(12):4056-7. PMID: 18923004; PMCID: PMC2593251.
      32. Graber CJ, Jacobson MA, Perdreau-Remington F, Chambers HF, Diep BA. Recurrence of skin and soft tissue infection caused by methicillin-resistant Staphylococcus aureus in a HIV primary care clinic. J Acquir Immune Defic Syndr. 2008 Oct 1; 49(2):231-3. PMID: 18820536.
        View in: PubMed
      33. Diep BA, Palazzolo-Ballance AM, Tattevin P, Basuino L, Braughton KR, Whitney AR, Chen L, Kreiswirth BN, Otto M, DeLeo FR, Chambers HF. Contribution of Panton-Valentine leukocidin in community-associated methicillin-resistant Staphylococcus aureus pathogenesis. PLoS One. 2008; 3(9):e3198. PMID: 18787708; PMCID: PMC2527530.
      34. Diep BA, Otto M. The role of virulence determinants in community-associated MRSA pathogenesis. Trends Microbiol. 2008 Aug; 16(8):361-9. PMID: 18585915; PMCID: PMC2778837.
      35. Diep BA, Stone GG, Basuino L, Graber CJ, Miller A, des Etages SA, Jones A, Palazzolo-Ballance AM, Perdreau-Remington F, Sensabaugh GF, DeLeo FR, Chambers HF. The arginine catabolic mobile element and staphylococcal chromosomal cassette mec linkage: convergence of virulence and resistance in the USA300 clone of methicillin-resistant Staphylococcus aureus. J Infect Dis. 2008 Jun 1; 197(11):1523-30. PMID: 18700257.
        View in: PubMed
      36. Liu C, Graber CJ, Karr M, Diep BA, Basuino L, Schwartz BS, Enright MC, O'Hanlon SJ, Thomas JC, Perdreau-Remington F, Gordon S, Gunthorpe H, Jacobs R, Jensen P, Leoung G, Rumack JS, Chambers HF. A population-based study of the incidence and molecular epidemiology of methicillin-resistant Staphylococcus aureus disease in San Francisco, 2004-2005. Clin Infect Dis. 2008 Jun 1; 46(11):1637-46. PMID: 18433335.
        View in: PubMed
      37. Miller LG, Diep BA. Clinical practice: colonization, fomites, and virulence: rethinking the pathogenesis of community-associated methicillin-resistant Staphylococcus aureus infection. Clin Infect Dis. 2008 Mar 1; 46(5):752-60. PMID: 18220477.
        View in: PubMed
      38. Diep BA, Chambers HF, Graber CJ, Szumowski JD, Miller LG, Han LL, Chen JH, Lin F, Lin J, Phan TH, Carleton HA, McDougal LK, Tenover FC, Cohen DE, Mayer KH, Sensabaugh GF, Perdreau-Remington F. Emergence of multidrug-resistant, community-associated, methicillin-resistant Staphylococcus aureus clone USA300 in men who have sex with men. Ann Intern Med. 2008 Feb 19; 148(4):249-57. PMID: 18283202.
        View in: PubMed
      39. Miller LG, Perdreau-Remington F, Bayer AS, Diep B, Tan N, Bharadwa K, Tsui J, Perlroth J, Shay A, Tagudar G, Ibebuogu U, Spellberg B. Clinical and epidemiologic characteristics cannot distinguish community-associated methicillin-resistant Staphylococcus aureus infection from methicillin-susceptible S. aureus infection: a prospective investigation. Clin Infect Dis. 2007 Feb 15; 44(4):471-82. PMID: 17243048.
        View in: PubMed
      40. Vivoni AM, Diep BA, de Gouveia Magalhães AC, Santos KR, Riley LW, Sensabaugh GF, Moreira BM. Clonal composition of Staphylococcus aureus isolates at a Brazilian university hospital: identification of international circulating lineages. J Clin Microbiol. 2006 May; 44(5):1686-91. PMID: 16672394; PMCID: PMC1479203.
      41. Diep BA, Carleton HA, Chang RF, Sensabaugh GF, Perdreau-Remington F. Roles of 34 virulence genes in the evolution of hospital- and community-associated strains of methicillin-resistant Staphylococcus aureus. J Infect Dis. 2006 Jun 1; 193(11):1495-503. PMID: 16652276.
        View in: PubMed
      42. Diep BA, Gill SR, Chang RF, Phan TH, Chen JH, Davidson MG, Lin F, Lin J, Carleton HA, Mongodin EF, Sensabaugh GF, Perdreau-Remington F. Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus. Lancet. 2006 Mar 4; 367(9512):731-9. PMID: 16517273.
        View in: PubMed
      43. Pan ES, Diep BA, Charlebois ED, Auerswald C, Carleton HA, Sensabaugh GF, Perdreau-Remington F. Population dynamics of nasal strains of methicillin-resistant Staphylococcus aureus--and their relation to community-associated disease activity. J Infect Dis. 2005 Sep 1; 192(5):811-8. PMID: 16088830.
        View in: PubMed
      44. Carleton HA, Diep BA, Charlebois ED, Sensabaugh GF, Perdreau-Remington F. Community-adapted methicillin-resistant Staphylococcus aureus (MRSA): population dynamics of an expanding community reservoir of MRSA. J Infect Dis. 2004 Nov 15; 190(10):1730-8. PMID: 15499526.
        View in: PubMed
      45. Charlebois ED, Perdreau-Remington F, Kreiswirth B, Bangsberg DR, Ciccarone D, Diep BA, Ng VL, Chansky K, Edlin BR, Edlin B, Chambers HF. Origins of community strains of methicillin-resistant Staphylococcus aureus. Clin Infect Dis. 2004 Jul 1; 39(1):47-54. PMID: 15206052; PMCID: PMC2567833.
      46. Lagally ET, Scherer JR, Blazej RG, Toriello NM, Diep BA, Ramchandani M, Sensabaugh GF, Riley LW, Mathies RA. Integrated portable genetic analysis microsystem for pathogen/infectious disease detection. Anal Chem. 2004 Jun 1; 76(11):3162-70. PMID: 15167797.
        View in: PubMed
      47. Diep BA, Sensabaugh GF, Somboonna N, Somboona NS, Carleton HA, Perdreau-Remington F. Widespread skin and soft-tissue infections due to two methicillin-resistant Staphylococcus aureus strains harboring the genes for Panton-Valentine leucocidin. J Clin Microbiol. 2004 May; 42(5):2080-4. PMID: 15131173; PMCID: PMC404676.
      48. Pan ES, Diep BA, Carleton HA, Charlebois ED, Sensabaugh GF, Haller BL, Perdreau-Remington F. Increasing prevalence of methicillin-resistant Staphylococcus aureus infection in California jails. Clin Infect Dis. 2003 Nov 15; 37(10):1384-8. PMID: 14583874.
        View in: PubMed
      49. Diep BA, Perdreau-Remington F, Sensabaugh GF. Clonal characterization of Staphylococcus aureus by multilocus restriction fragment typing, a rapid screening approach for molecular epidemiology. J Clin Microbiol. 2003 Oct; 41(10):4559-64. PMID: 14532182; PMCID: PMC254328.
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