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Brent Molden, MD, PhD

Address505 Parnassus Avenue
San Francisco CA 94117
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    Mechanism of the desensitization of MC4R
    NIH/NIDDK F30DK095569Jul 1, 2012 - Jun 30, 2015
    Role: Principal Investigator
    Mechanism of the desensitization of MC4R
    NIH/NIDDK F30DK095569Jul 1, 2012 - Jun 30, 2015
    Role: Principal Investigator
    Mechanism of the desensitization of MC4R
    NIH/NIDDK F30DK095569Jul 1, 2012 - Jun 30, 2015
    Role: Principal Investigator

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    1. Granell S, Molden BM, Baldini G. Exposure of MC4R to agonist in the endoplasmic reticulum stabilizes an active conformation of the receptor that does not desensitize. Proc Natl Acad Sci U S A. 2013 Dec 3; 110(49):E4733-42. PMID: 24248383; PMCID: PMC3856822.
    2. McDaniel FK, Molden BM, Mohammad S, Baldini G, McPike L, Narducci P, Granell S, Baldini G. Constitutive cholesterol-dependent endocytosis of melanocortin-4 receptor (MC4R) is essential to maintain receptor responsiveness to a-melanocyte-stimulating hormone (a-MSH). J Biol Chem. 2012 Jun 22; 287(26):21873-90. PMID: 22544740; PMCID: PMC3381150.
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