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    Brian Hearn, PhD

    TitleAssociate Director
    SchoolUCSF School of Pharmacy
    DepartmentPharmaceutical Chemistry
    AddressQB3 Fifth Floor South
    San Francisco Ca 94158
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Gallagher CM, Garri C, Cain EL, Ang KK, Wilson CG, Chen S, Hearn BR, Jaishankar P, Aranda-Diaz A, Arkin MR, Renslo AR, Walter P. Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6a branch. Elife. 2016; 5. PMID: 27435960.
        View in: PubMed
      2. Hearn BR, Jaishankar P, Sidrauski C, Tsai JC, Vedantham P, Fontaine SD, Walter P, Renslo AR. Structure-Activity Studies of Bis-O-Arylglycolamides: Inhibitors of the Integrated Stress Response. ChemMedChem. 2016 Apr 19; 11(8):870-80. PMID: 26789650.
        View in: PubMed
      3. Sidrauski C, Tsai JC, Kampmann M, Hearn BR, Vedantham P, Jaishankar P, Sokabe M, Mendez AS, Newton BW, Tang EL, Verschueren E, Johnson JR, Krogan NJ, Fraser CS, Weissman JS, Renslo AR, Walter P. Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response. Elife. 2015; 4:e07314. PMID: 25875391; PMCID: PMC4426669.
      4. Henise J, Hearn BR, Ashley GW, Santi DV. Biodegradable tetra-PEG hydrogels as carriers for a releasable drug delivery system. Bioconjug Chem. 2015 Feb 18; 26(2):270-8. PMID: 25584814.
        View in: PubMed
      5. Gable JE, Lee GM, Jaishankar P, Hearn BR, Waddling CA, Renslo AR, Craik CS. Broad-spectrum allosteric inhibition of herpesvirus proteases. Biochemistry. 2014 Jul 22; 53(28):4648-60. PMID: 24977643; PMCID: PMC4108181.
      6. Murray J, Giannetti AM, Steffek M, Gibbons P, Hearn BR, Cohen F, Tam C, Pozniak C, Bravo B, Lewcock J, Jaishankar P, Ly CQ, Zhao X, Tang Y, Chugha P, Arkin MR, Flygare J, Renslo AR. Tailoring small molecules for an allosteric site on procaspase-6. ChemMedChem. 2014 Jan; 9(1):73-7, 2. PMID: 24259468.
        View in: PubMed
      7. Sidrauski C, Acosta-Alvear D, Khoutorsky A, Vedantham P, Hearn BR, Li H, Gamache K, Gallagher CM, Ang KK, Wilson C, Okreglak V, Ashkenazi A, Hann B, Nader K, Arkin MR, Renslo AR, Sonenberg N, Walter P. Pharmacological brake-release of mRNA translation enhances cognitive memory. Elife. 2013; 2:e00498. PMID: 23741617; PMCID: PMC3667625.
      8. Heise CE, Murray J, Augustyn KE, Bravo B, Chugha P, Cohen F, Giannetti AM, Gibbons P, Hannoush RN, Hearn BR, Jaishankar P, Ly CQ, Shah K, Stanger K, Steffek M, Tang Y, Zhao X, Lewcock JW, Renslo AR, Flygare J, Arkin MR. Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6. PLoS One. 2012; 7(12):e50864. PMID: 23227217; PMCID: PMC3515450.
      9. Rafi SB, Hearn BR, Vedantham P, Jacobson MP, Renslo AR. Predicting and improving the membrane permeability of peptidic small molecules. J Med Chem. 2012 Apr 12; 55(7):3163-9. PMID: 22394492; PMCID: PMC3325374.
      10. Hearn BR, Sundermann K, Cannoy J, Santi DV. Semisynthesis and cytotoxicity of hypothemycin analogues. ChemMedChem. 2007 Nov; 2(11):1598-600. PMID: 17691074.
        View in: PubMed
      11. Hearn BR, Zhang D, Li Y, Myles DC. C-15 thiazol-4-yl analogues of (E)-9,10-didehydroepothilone D: synthesis and cytotoxicity. Org Lett. 2006 Jul 6; 8(14):3057-9. PMID: 16805551.
        View in: PubMed
      12. Hearn BR, Arslanian RL, Fu H, Liu F, Gramajo H, Myles DC. Methanolysis products of disorazole A1. J Nat Prod. 2006 Jan; 69(1):148-50. PMID: 16441089.
        View in: PubMed
      13. Taylor RE, Hearn BR, Ciavarri JP. A divergent approach to the myriaporones and tedanolide: completion of the carbon skeleton of myriaporone 1. Org Lett. 2002 Aug 22; 4(17):2953-5. PMID: 12182597.
        View in: PubMed
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