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    Brian Malone, PhD

    TitleAssistant Professor
    SchoolUCSF School of Medicine
    Address675 Nelson Rising Lane
    San Francisco CA 94158
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      Brian Malone, PhD, is an Assistant Adjunct Professor in the Department of Otolaryngology - Head and Neck Surgery at the University of California, San Francisco. He specializes in the neurophysiology of the central auditory system, with a focus on the cortical representation of dynamic sounds. Dr. Malone's overall goal is to understand the fundamental neural coding principles that enable robust speech comprehension in challenging listening environments. By pursuing basic research on this issue, Dr. Malone hopes to use the knowledge gained to guide the development of novel therapeutic approaches to communicative disorders, such as algorithms for speech enhancement in hearing aids, and stimulation protocols for neural prosthetic devices for hearing.

      His laboratory employs multichannel electrophysiological recordings, computational models, and psychophysical approaches to answer fundamental questions about how auditory cortex processes complex sounds amid competing background noise. Much of his recent research has focused on the encoding of low frequency envelope information because such information is crucial for intelligible speech, and a chief goal for the laboratory is to develop a better general framework for understanding cortical envelope processing.

      Dr. Malone has been awarded funding from the National Institutes of Health for his predoctoral (NRSA), postdoctoral (NRSA), and current (R01) research at the John C. and Edward Coleman Memorial Laboratory of the Department.

      Sound encoding in the core fields of auditory cortex

      Computationally-driven neurophysiological characterization of how features of sounds are encoded and represented in the firing patterns of cortical neurons

      Professional Interests:
      Developing computational models of auditory receptive fields that capture nonlinear features of the cortical encoding model, and investigating how those features contribute to complex perceptual tasks such as auditory scene segmentation, speech comprehension, and timbral discrimination

      Education and Training:
      • Doctoral: New York University - Neural Sciences
      • Postdoctoral: David Geffen School of Medicine at UCLA - Image processing in primary visual cortex

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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Teschner MJ, Seybold BA, Malone BJ, Hüning J, Schreiner CE. Effects of Signal-to-Noise Ratio on Auditory Cortical Frequency Processing. J Neurosci. 2016 Mar 2; 36(9):2743-56. PMID: 26937012.
        View in: PubMed
      2. Malone BJ, Beitel RE, Vollmer M, Heiser MA, Schreiner CE. Modulation-frequency-specific adaptation in awake auditory cortex. J Neurosci. 2015 Apr 15; 35(15):5904-16. PMID: 25878263; PMCID: PMC4397592.
      3. Malone BJ, Scott BH, Semple MN. Diverse cortical codes for scene segmentation in primate auditory cortex. J Neurophysiol. 2015 Apr 1; 113(7):2934-52. PMID: 25695655; PMCID: PMC4416616 [Available on 04/01/16].
      4. Schreiner CE, Malone BJ. Representation of loudness in the auditory cortex. Handb Clin Neurol. 2015; 129:73-84. PMID: 25726263.
        View in: PubMed
      5. Malone BJ, Scott BH, Semple MN. Encoding frequency contrast in primate auditory cortex. J Neurophysiol. 2014 Jun 1; 111(11):2244-63. PMID: 24598525; PMCID: PMC4097870.
      6. Malone BJ, Beitel RE, Vollmer M, Heiser MA, Schreiner CE. Spectral context affects temporal processing in awake auditory cortex. J Neurosci. 2013 May 29; 33(22):9431-50. PMID: 23719811; PMCID: PMC3829847.
      7. Cattaruzza F, Johnson C, Leggit A, Grady E, Schenk AK, Cevikbas F, Cedron W, Bondada S, Kirkwood R, Malone B, Steinhoff M, Bunnett N, Kirkwood KS. Transient receptor potential ankyrin 1 mediates chronic pancreatitis pain in mice. Am J Physiol Gastrointest Liver Physiol. 2013 Jun 1; 304(11):G1002-12. PMID: 23558009; PMCID: PMC3680686.
      8. Scott BH, Malone BJ, Semple MN. Transformation of temporal processing across auditory cortex of awake macaques. J Neurophysiol. 2011 Feb; 105(2):712-30. PMID: 21106896; PMCID: PMC3059172.
      9. Malone BJ, Scott BH, Semple MN. Temporal codes for amplitude contrast in auditory cortex. J Neurosci. 2010 Jan 13; 30(2):767-84. PMID: 20071542; PMCID: PMC3551278.
      10. Scott BH, Malone BJ, Semple MN. Representation of dynamic interaural phase difference in auditory cortex of awake rhesus macaques. J Neurophysiol. 2009 Apr; 101(4):1781-99. PMID: 19164111; PMCID: PMC2695633.
      11. Malone BJ, Ringach DL. Dynamics of tuning in the Fourier domain. J Neurophysiol. 2008 Jul; 100(1):239-48. PMID: 18480369; PMCID: PMC2493484.
      12. Ringach DL, Malone BJ. The operating point of the cortex: neurons as large deviation detectors. J Neurosci. 2007 Jul 18; 27(29):7673-83. PMID: 17634362.
        View in: PubMed
      13. Malone BJ, Scott BH, Semple MN. Dynamic amplitude coding in the auditory cortex of awake rhesus macaques. J Neurophysiol. 2007 Sep; 98(3):1451-74. PMID: 17615123.
        View in: PubMed
      14. Scott BH, Malone BJ, Semple MN. Effect of behavioral context on representation of a spatial cue in core auditory cortex of awake macaques. J Neurosci. 2007 Jun 13; 27(24):6489-99. PMID: 17567810.
        View in: PubMed
      15. Malone BJ, Kumar VR, Ringach DL. Dynamics of receptive field size in primary visual cortex. J Neurophysiol. 2007 Jan; 97(1):407-14. PMID: 17021020.
        View in: PubMed
      16. Braune BM, Malone BJ. Organochlorines and trace elements in upland game birds harvested in Canada. Sci Total Environ. 2006 Jun 15; 363(1-3):60-9. PMID: 16055172.
        View in: PubMed
      17. Malone BJ, Scott BH, Semple MN. Context-dependent adaptive coding of interaural phase disparity in the auditory cortex of awake macaques. J Neurosci. 2002 Jun 1; 22(11):4625-38. PMID: 12040069.
        View in: PubMed
      18. Malone BJ, Semple MN. Effects of auditory stimulus context on the representation of frequency in the gerbil inferior colliculus. J Neurophysiol. 2001 Sep; 86(3):1113-30. PMID: 11535662.
        View in: PubMed
      19. Sanes DH, Malone BJ, Semple MN. Role of synaptic inhibition in processing of dynamic binaural level stimuli. J Neurosci. 1998 Jan 15; 18(2):794-803. PMID: 9425020.
        View in: PubMed
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