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    Bruce Faddegon, PhD

    TitleProfessor
    SchoolUCSF School of Medicine
    DepartmentRadiation Oncology
    Address1600 Divisadero
    San Francisco CA 94115
    Phone415-353-7195
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      Dr. Faddegon is a board certified clinical medical physics who is internationally recognized for his research in developing and using Monte Carlo methods for treatment head simulation and dose calculation with an eye to improving accuracy and precision in radiotherapy. The overall objective of Dr. Faddegon’s research is to allow for more aggressive treatment in sites where side effects, local control, and even metastases are a problem through cost-effective solutions to improve the therapeutic ratio.

      Current research includes developing TOPAS, the Tool for Particle Simulation, a collaboration of UCSF, MGH and SLAC supported by NIH to improve advanced simulation of proton therapy, and developing XPERT, X-ray Plus Electron Radiotherapy, adding electrons to intensity-modulated radiotherapy with x-rays to reduce serious side-effects of radiation, especially in children. Dr. Faddegon is also working to establish image-guided radiotherapy with portal imaging for more precise targeting of tumors and avoidance of critical structures.

      Dr. Faddegons clinical responsibility is physics support of linear accelerators (linacs). This includes management, installation, commissioning, maintenance and quality assurance. Highlights of Dr. Faddegon’s published clinical development work at UCSF include developing the means to treat the whole body over a short distance (3 meters), developing new x-ray targets to reduce downtime that are implemented on linacs worldwide, implementing high precision graticules for patient localization, and determining the means to detect and correct defective circuitry in treatments using virtual wedges.


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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Sudhyadhom A, Kirby N, Faddegon B, Chuang CF. Technical Note: Preferred dosimeter size and associated correction factors in commissioning high dose per pulse, flattening filter free x-ray beams. Med Phys. 2016 Mar; 43(3):1507. PMID: 26936734.
        View in: PubMed
      2. Geng C, Moteabbed M, Seco J, Gao Y, George Xu X, Ramos-Méndez J, Faddegon B, Paganetti H. Dose assessment for the fetus considering scattered and secondary radiation from photon and proton therapy when treating a brain tumor of the mother. Phys Med Biol. 2016 Jan 21; 61(2):683-95. PMID: 26716718.
        View in: PubMed
      3. Faddegon BA, Shin J, Castenada CM, Ramos-Méndez J, Daftari IK. Experimental depth dose curves of a 67.5 MeV proton beam for benchmarking and validation of Monte Carlo simulation. Med Phys. 2015 Jul; 42(7):4199-210. PMID: 26133619; PMCID: PMC4474955 [Available on 07/01/16].
      4. Ramos-Méndez J, Perl J, Schümann J, Shin J, Paganetti H, Faddegon B. A framework for implementation of organ effect models in TOPAS with benchmarks extended to proton therapy. Phys Med Biol. 2015 Jul 7; 60(13):5037-52. PMID: 26061583; PMCID: PMC4498397 [Available on 07/07/16].
      5. Polster L, Schuemann J, Rinaldi I, Burigo L, McNamara AL, Stewart RD, Attili A, Carlson DJ, Sato T, Ramos Méndez J, Faddegon B, Perl J, Paganetti H. Extension of TOPAS for the simulation of proton radiation effects considering molecular and cellular endpoints. Phys Med Biol. 2015 Jul 7; 60(13):5053-70. PMID: 26061666; PMCID: PMC4511084 [Available on 07/07/16].
      6. Méndez JR, Perl J, Schümann J, Shin J, Paganetti H, Faddegon B. Improved efficiency in Monte Carlo simulation for passive-scattering proton therapy. Phys Med Biol. 2015 Jul 7; 60(13):5019-35. PMID: 26061457; PMCID: PMC4498399 [Available on 07/07/16].
      7. Shiao SL, Ruffell B, DeNardo DG, Faddegon BA, Park CC, Coussens LM. TH2-Polarized CD4(+) T Cells and Macrophages Limit Efficacy of Radiotherapy. Cancer Immunol Res. 2015 May; 3(5):518-25. PMID: 25716473; PMCID: PMC4420686 [Available on 05/01/16].
      8. Testa M, Schümann J, Lu HM, Shin J, Faddegon B, Perl J, Paganetti H. Experimental validation of the TOPAS Monte Carlo system for passive scattering proton therapy. Med Phys. 2013 Dec; 40(12):121719. PMID: 24320505; PMCID: PMC4109425.
      9. Ramos-Méndez J, Perl J, Faddegon B, Schümann J, Paganetti H. Geometrical splitting technique to improve the computational efficiency in Monte Carlo calculations for proton therapy. Med Phys. 2013 Apr; 40(4):041718. PMID: 23556888; PMCID: PMC3618101.
      10. Perl J, Shin J, Schumann J, Faddegon B, Paganetti H. TOPAS: an innovative proton Monte Carlo platform for research and clinical applications. Med Phys. 2012 Nov; 39(11):6818-37. PMID: 23127075; PMCID: PMC3493036.
      11. Choi G, Huang B, Pinarbasi E, Braunstein SE, Horvai AE, Kogan S, Bhatia S, Faddegon B, Nakamura JL. Genetically mediated Nf1 loss in mice promotes diverse radiation-induced tumors modeling second malignant neoplasms. Cancer Res. 2012 Dec 15; 72(24):6425-34. PMID: 23071067; PMCID: PMC3787120.
      12. Schümann J, Paganetti H, Shin J, Faddegon B, Perl J. Efficient voxel navigation for proton therapy dose calculation in TOPAS and Geant4. Phys Med Biol. 2012 Jun 7; 57(11):3281-93. PMID: 22572154; PMCID: PMC3367506.
      13. Shin J, Perl J, Schümann J, Paganetti H, Faddegon BA. A modular method to handle multiple time-dependent quantities in Monte Carlo simulations. Phys Med Biol. 2012 Jun 7; 57(11):3295-308. PMID: 22572201; PMCID: PMC4477630.
      14. Schreiber EC, Sawkey DL, Faddegon BA. Sensitivity analysis of an asymmetric Monte Carlo beam model of a Siemens Primus accelerator. J Appl Clin Med Phys. 2012; 13(2):3402. PMID: 22402376.
        View in: PubMed
      15. O'Shea TP, Ge Y, Foley MJ, Faddegon BA. Characterization of an extendable multi-leaf collimator for clinical electron beams. Phys Med Biol. 2011 Dec 7; 56(23):7621-38. PMID: 22086242.
        View in: PubMed
      16. Ge Y, Faddegon BA. Study of intensity-modulated photon-electron radiation therapy using digital phantoms. Phys Med Biol. 2011 Oct 21; 56(20):6693-708. PMID: 21965269.
        View in: PubMed
      17. O'Shea TP, Foley MJ, Faddegon BA. Accounting for the fringe magnetic field from the bending magnet in a Monte Carlo accelerator treatment head simulation. Med Phys. 2011 Jun; 38(6):3260-9. PMID: 21815400.
        View in: PubMed
      18. Nakamura JL, Phong C, Pinarbasi E, Kogan SC, Vandenberg S, Horvai AE, Faddegon BA, Fiedler D, Shokat K, Houseman BT, Chao R, Pieper RO, Shannon K. Dose-dependent effects of focal fractionated irradiation on secondary malignant neoplasms in Nf1 mutant mice. Cancer Res. 2011 Jan 1; 71(1):106-15. PMID: 21199799; PMCID: PMC3077533.
      19. Halabi T, Faddegon B. Practical quantitative measurement of graticule misalignment relative to collimator axis of rotation. J Appl Clin Med Phys. 2010; 11(4):3318. PMID: 21081892.
        View in: PubMed
      20. O'Shea TP, Sawkey DL, Foley MJ, Faddegon BA. Monte Carlo commissioning of clinical electron beams using large field measurements. Phys Med Biol. 2010 Jul 21; 55(14):4083-105. PMID: 20601775.
        View in: PubMed
      21. Faddegon BA, Aubin M, Bani-Hashemi A, Gangadharan B, Gottschalk AR, Morin O, Sawkey D, Wu V, Yom SS. Comparison of patient megavoltage cone beam CT images acquired with an unflattened beam from a carbon target and a flattened treatment beam. Med Phys. 2010 Apr; 37(4):1737-41. PMID: 20443494.
        View in: PubMed
      22. Sawkey D, Lu M, Morin O, Aubin M, Yom SS, Gottschalk AR, Bani-Hashemi A, Faddegon BA. A diamond target for megavoltage cone-beam CT. Med Phys. 2010 Mar; 37(3):1246-53. PMID: 20384262.
        View in: PubMed
      23. Sawkey D, Faddegon BA. Simulation of large x-ray fields using independently measured source and geometry details. Med Phys. 2009 Dec; 36(12):5622-32. PMID: 20095275; PMCID: PMC2792331.
      24. Fragoso M, Kawrakow I, Faddegon BA, Solberg TD, Chetty IJ. Fast, accurate photon beam accelerator modeling using BEAMnrc: a systematic investigation of efficiency enhancing methods and cross-section data. Med Phys. 2009 Dec; 36(12):5451-66. PMID: 20095258; PMCID: PMC2787063.
      25. Faddegon BA, Sawkey D, O'Shea T, McEwen M, Ross C. Treatment head disassembly to improve the accuracy of large electron field simulation. Med Phys. 2009 Oct; 36(10):4577-91. PMID: 19928089; PMCID: PMC2771714.
      26. Faddegon BA, Kawrakow I, Kubyshin Y, Perl J, Sempau J, Urban L. The accuracy of EGSnrc, Geant4 and PENELOPE Monte Carlo systems for the simulation of electron scatter in external beam radiotherapy. Phys Med Biol. 2009 Oct 21; 54(20):6151-63. PMID: 19779217; PMCID: PMC3462739.
      27. Chen J, Irion J, Faddegon BA. Validation of the final aperture superposition technique to calculate electron output factors and depth dose curves. Med Phys. 2009 Aug; 36(8):3397-405. PMID: 19746772.
        View in: PubMed
      28. Beltran C, Lukose R, Gangadharan B, Bani-Hashemi A, Faddegon BA. Image quality & dosimetric property of an investigational imaging beam line MV-CBCT. J Appl Clin Med Phys. 2009; 10(3):3023. PMID: 19692984.
        View in: PubMed
      29. Sawkey DL, Faddegon BA. Determination of electron energy, spectral width, and beam divergence at the exit window for clinical megavoltage x-ray beams. Med Phys. 2009 Mar; 36(3):698-707. PMID: 19378730; PMCID: PMC2673678.
      30. Faddegon BA, Wu V, Pouliot J, Gangadharan B, Bani-Hashemi A. Low dose megavoltage cone beam computed tomography with an unflattened 4 MV beam from a carbon target. Med Phys. 2008 Dec; 35(12):5777-86. PMID: 19175135.
        View in: PubMed
      31. Maltz JS, Gangadharan B, Bose S, Hristov DH, Faddegon BA, Paidi A, Bani-Hashemi AR. Algorithm for X-ray scatter, beam-hardening, and beam profile correction in diagnostic (kilovoltage) and treatment (megavoltage) cone beam CT. IEEE Trans Med Imaging. 2008 Dec; 27(12):1791-810. PMID: 19033095.
        View in: PubMed
      32. Faddegon BA, Asai M, Perl J, Ross C, Sempau J, Tinslay J, Salvat F. Benchmarking of Monte Carlo simulation of bremsstrahlung from thick targets at radiotherapy energies. Med Phys. 2008 Oct; 35(10):4308-17. PMID: 18975676; PMCID: PMC2736754.
      33. Ross CK, McEwen MR, McDonald AF, Cojocaru CD, Faddegon BA. Measurement of multiple scattering of 13 and 20 MeV electrons by thin foils. Med Phys. 2008 Sep; 35(9):4121-31. PMID: 18841865; PMCID: PMC2673663.
      34. Maltz JS, Gangadharan B, Vidal M, Paidi A, Bose S, Faddegon BA, Aubin M, Morin O, Pouliot J, Zheng Z, Svatos MM, Bani-Hashemi AR. Focused beam-stop array for the measurement of scatter in megavoltage portal and cone beam CT imaging. Med Phys. 2008 Jun; 35(6):2452-62. PMID: 18649478.
        View in: PubMed
      35. Janssen RW, Faddegon BA, Dries WJ. Prototyping a large field size IORT applicator for a mobile linear accelerator. Phys Med Biol. 2008 Apr 21; 53(8):2089-102. PMID: 18369280.
        View in: PubMed
      36. Faddegon BA, Perl J, Asai M. Monte Carlo simulation of large electron fields. Phys Med Biol. 2008 Mar 7; 53(5):1497-510. PMID: 18296775; PMCID: PMC2900835.
      37. Chetty IJ, Curran B, Cygler JE, DeMarco JJ, Ezzell G, Faddegon BA, Kawrakow I, Keall PJ, Liu H, Ma CM, Rogers DW, Seuntjens J, Sheikh-Bagheri D, Siebers JV. Report of the AAPM Task Group No. 105: Issues associated with clinical implementation of Monte Carlo-based photon and electron external beam treatment planning. Med Phys. 2007 Dec; 34(12):4818-53. PMID: 18196810.
        View in: PubMed
      38. Ozawa T, Faddegon BA, Hu LJ, Bollen AW, Lamborn KR, Deen DF. Response of intracerebral human glioblastoma xenografts to multifraction radiation exposures. Int J Radiat Oncol Biol Phys. 2006 Sep 1; 66(1):263-70. PMID: 16904526.
        View in: PubMed
      39. Faddegon BA, Garde E. A pulse-rate dependence of dose per monitor unit and its significant effect on wedged-shaped fields delivered with variable dose rate and a moving jaw. Med Phys. 2006 Aug; 33(8):3063-5. PMID: 16964884.
        View in: PubMed
      40. Beddar AS, Biggs PJ, Chang S, Ezzell GA, Faddegon BA, Hensley FW, Mills MD. Intraoperative radiation therapy using mobile electron linear accelerators: report of AAPM Radiation Therapy Committee Task Group No. 72. Med Phys. 2006 May; 33(5):1476-89. PMID: 16752582.
        View in: PubMed
      41. Faddegon BA, Villarreal-Barajas JE. Final Aperture Superposition Technique applied to fast calculation of electron output factors and depth dose curves. Med Phys. 2005 Nov; 32(11):3286-94. PMID: 16370417.
        View in: PubMed
      42. Faddegon B, Schreiber E, Ding X. Monte Carlo simulation of large electron fields. Phys Med Biol. 2005 Mar 7; 50(5):741-53. PMID: 15798251.
        View in: PubMed
      43. Schreiber EC, Faddegon BA. Sensitivity of large-field electron beams to variations in a Monte Carlo accelerator model. Phys Med Biol. 2005 Mar 7; 50(5):769-78. PMID: 15798253.
        View in: PubMed
      44. Coleman J, Park C, Villarreal-Barajas JE, Petti P, Faddegon B. A comparison of Monte Carlo and Fermi-Eyges-Hogstrom estimates of heart and lung dose from breast electron boost treatment. Int J Radiat Oncol Biol Phys. 2005 Feb 1; 61(2):621-8. PMID: 15667984.
        View in: PubMed
      45. Hogstrom KR, Boyd RA, Antolak JA, Svatos MM, Faddegon BA, Rosenman JG. Dosimetry of a prototype retractable eMLC for fixed-beam electron therapy. Med Phys. 2004 Mar; 31(3):443-62. PMID: 15070241.
        View in: PubMed
      46. Faddegon B, Egley B, Steinberg T. Comparison of beam characteristics of a gold x-ray target and a tungsten replacement target. Med Phys. 2004 Jan; 31(1):91-7. PMID: 14761025.
        View in: PubMed
      47. Hartmann Siantar CL, Walling RS, Daly TP, Faddegon B, Albright N, Bergstrom P, Bielajew AF, Chuang C, Garrett D, House RK, Knapp D, Wieczorek DJ, Verhey LJ. Description and dosimetric verification of the PEREGRINE Monte Carlo dose calculation system for photon beams incident on a water phantom. Med Phys. 2001 Jul; 28(7):1322-37. PMID: 11488562.
        View in: PubMed
      48. Faddegon BA, Blevis I. Electron spectra derived from depth dose distributions. Med Phys. 2000 Mar; 27(3):514-26. PMID: 10757603.
        View in: PubMed
      49. Faddegon BA, O'Brien P, Mason DL. The flatness of Siemens linear accelerator x-ray fields. Med Phys. 1999 Feb; 26(2):220-8. PMID: 10076978.
        View in: PubMed
      50. Ostapiak OZ, O'Brien PF, Faddegon BA. Megavoltage imaging with low Z targets: implementation and characterization of an investigational system. Med Phys. 1998 Oct; 25(10):1910-8. PMID: 9800698.
        View in: PubMed
      51. Ma CM, Faddegon BA, Rogers DW, Mackie TR. Accurate characterization of Monte Carlo calculated electron beams for radiotherapy. Med Phys. 1997 Mar; 24(3):401-16. PMID: 9089592.
        View in: PubMed
      52. Scora D, Faddegon BA. Monte Carlo based phase-space evolution for electron dose calculation. Med Phys. 1997 Feb; 24(2):177-87. PMID: 9048357.
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      53. Sixel KE, Faddegon BA. Calculation of x-ray spectra for radiosurgical beams. Med Phys. 1995 Oct; 22(10):1657-61. PMID: 8551991.
        View in: PubMed
      54. Rogers DW, Faddegon BA, Ding GX, Ma CM, We J, Mackie TR. BEAM: a Monte Carlo code to simulate radiotherapy treatment units. Med Phys. 1995 May; 22(5):503-24. PMID: 7643786.
        View in: PubMed
      55. Faddegon BA, Ross CK, Rogers DW. Angular distribution of bremsstrahlung from 15-MeV electrons incident on thick targets of Be, Al, and Pb. Med Phys. 1991 Jul-Aug; 18(4):727-39. PMID: 1921878.
        View in: PubMed
      56. Faddegon BA, Ross CK, Rogers DW. Forward-directed bremsstrahlung of 10- to 30-MeV electrons incident on thick targets of Al and Pb. Med Phys. 1990 Sep-Oct; 17(5):773-85. PMID: 2233563.
        View in: PubMed
      57. Faddegon BA, Pfalzner P. Computer aided design and verification of megavoltage tissue compensators for oblique beams. Med Phys. 1988 Sep-Oct; 15(5):757-62. PMID: 3141758.
        View in: PubMed
      58. Palcic B, Faddegon B, Skarsgard LD. The effect of misonidazole as a hypoxic radiosensitizer at low dose. Radiat Res. 1984 Nov; 100(2):340-7. PMID: 6494445.
        View in: PubMed
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