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    Buck Strewler, MD

    TitleProfessor
    SchoolUCSF School of Medicine
    DepartmentMedicine
    Address533 Parnassus Avenue
    San Francisco CA 94117
    Phone415-502-5154
    vCardDownload vCard

      Collapse Biography 
      Collapse Education and Training
      Dartmouth CollegeA.B.1968
      Harvard Medical SchoolM.D.1971
      Peter Bent Brigham HospitalInternship and Residency1973
      NHLBI/NIHFellowshipEndocrinology-Metabolism1979
      Collapse Awards and Honors
      1987American Society for Clinical Investigation
      1996Best Doctors in America
      HMS Second Year Class2003Best Lecturer, Module 2
      Harvard Medical School2003Elected to Aesculapian Club
      Boston Magazine2006Best Doctors in Boston
      Dept of Medicine, Beth Israel Deaconess2009Mentorship of Resident Research Award
      Harvard Medical School2014Tutorial Excellence Award

      Collapse Overview 
      Collapse Overview
      Gordon "Buck" Strewler grew up in northern Minnesota and graduated from Dartmouth College and Harvard Medical School. He was an intern and resident at Peter Bent Brigham Hospital, the predecessor of Brigham and Women's. After clinical and research training in Endocrinology-Metabolism at the National Institutes of Health, he joined the UCSF faculty in 1979. He is an expert in calcium and bone metabolism; With Robert Nissenson, PhD,his laboratory identified, sequenced and cloned the parathyroid hormone-related protein, PTHrP, developed an assay to detect PTHrP in patients with hypercalcemia, and led the way to the understanding of its role in disease. He was Chief of the Endocrine Unit at the SFVAMC and also directed the UCSF Endocrinology Fellowship Program. Dr. Strewler returned to Boston in 1996. He was Chief of Medicine at the West Roxbury VA Medical Center (now part of the VA Boston Healthcare System) until 2001, when he became Master of the Walter Bradford Cannon Society, one of five learning communities in which Harvard medical students spend their academic lives. He subsequently became Director of the Scholars in Medicine program at HMS and Vice Chair for Education in the department of medicine at Beth Israel Deaconess Medical Center. He returned to UCSF in September, 2015 to join the Inquiry leadership team.


      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Farag N, Delbanco T, Strewler GJ. Update: A 64-year-old woman with primary hyperparathyroidism. JAMA. 2008 Nov 5; 300(17):2044-5. PMID: 18984891.
        View in: PubMed
      2. Strewler GJ. Untangling klotho's role in calcium homeostasis. Cell Metab. 2007 Aug; 6(2):93-5. PMID: 17681143.
        View in: PubMed
      3. Wang EP, Kaban LB, Strewler GJ, Raje N, Troulis MJ. Incidence of osteonecrosis of the jaw in patients with multiple myeloma and breast or prostate cancer on intravenous bisphosphonate therapy. J Oral Maxillofac Surg. 2007 Jul; 65(7):1328-31. PMID: 17577497.
        View in: PubMed
      4. Strewler GJ. A 64-year-old woman with primary hyperparathyroidism. JAMA. 2005 Apr 13; 293(14):1772-9. PMID: 15827317.
        View in: PubMed
      5. Elmquist JK, Strewler GJ. Physiology: do neural signals remodel bone? Nature. 2005 Mar 24; 434(7032):447-8. PMID: 15791237.
        View in: PubMed
      6. Strewler GJ. Decimal point--osteoporosis therapy at the 10-year mark. N Engl J Med. 2004 Mar 18; 350(12):1172-4. PMID: 15028820.
        View in: PubMed
      7. Strewler GJ. FGF23, hypophosphatemia, and rickets: has phosphatonin been found? Proc Natl Acad Sci U S A. 2001 May 22; 98(11):5945-6. PMID: 11371627; PMCID: PMC33399.
      8. Strewler GJ. Local and systemic control of the osteoblast. J Clin Invest. 2001 Feb; 107(3):271-2. PMID: 11160149; PMCID: PMC199200.
      9. Strewler GJ. Medical approaches to primary hyperparathyroidism. Endocrinol Metab Clin North Am. 2000 Sep; 29(3):523-39, vi. PMID: 11033759.
        View in: PubMed
      10. Strewler GJ. The parathyroid hormone-related protein. Endocrinol Metab Clin North Am. 2000 Sep; 29(3):629-45. PMID: 11033764.
        View in: PubMed
      11. Strewler GJ. The physiology of parathyroid hormone-related protein. N Engl J Med. 2000 Jan 20; 342(3):177-85. PMID: 10639544.
        View in: PubMed
      12. Chang W, Tu C, Bajra R, Komuves L, Miller S, Strewler G, Shoback D. Calcium sensing in cultured chondrogenic RCJ3.1C5.18 cells. Endocrinology. 1999 Apr; 140(4):1911-9. PMID: 10098531.
        View in: PubMed
      13. Lane NE, Kimmel DB, Nilsson MH, Cohen FE, Newton S, Nissenson RA, Strewler GJ. Bone-selective analogs of human PTH(1-34) increase bone formation in an ovariectomized rat model. J Bone Miner Res. 1996 May; 11(5):614-25. PMID: 9157776.
        View in: PubMed
      14. Funk JL, Moser AH, Strewler GJ, Feingold KR, Grünfeld C. Parathyroid hormone-related protein is induced during lethal endotoxemia and contributes to endotoxin-induced mortality in rodents. Mol Med. 1996 Mar; 2(2):204-10. PMID: 8726463; PMCID: PMC2230122.
      15. Lane NE, Thompson JM, Strewler GJ, Kinney JH. Intermittent treatment with human parathyroid hormone (hPTH[1-34]) increased trabecular bone volume but not connectivity in osteopenic rats. J Bone Miner Res. 1995 Oct; 10(10):1470-7. PMID: 8686502.
        View in: PubMed
      16. Funk JL, Lausier J, Moser AH, Shigenaga JK, Huling S, Nissenson RA, Strewler GJ, Grunfeld C, Feingold KR. Endotoxin induces parathyroid hormone-related protein gene expression in splenic stromal and smooth muscle cells, not in splenic lymphocytes. Endocrinology. 1995 Aug; 136(8):3412-21. PMID: 7628377.
        View in: PubMed
      17. Strewler GJ. Indications for surgery in patients with minimally symptomatic primary hyperparathyroidism. Surg Clin North Am. 1995 Jun; 75(3):439-47. PMID: 7747251.
        View in: PubMed
      18. Schermer DT, Bradley MS, Bambino TH, Nissenson RA, Strewler GJ. Functional properties of a synthetic chicken parathyroid hormone-related protein 1-36 fragment. J Bone Miner Res. 1994 Jul; 9(7):1041-6. PMID: 7942150.
        View in: PubMed
      19. Funk JL, Shigenaga JK, Moser AH, Krul EJ, Strewler GJ, Feingold KR, Grunfeld C. Cytokine regulation of parathyroid hormone-related protein messenger ribonucleic acid levels in mouse spleen: paradoxical effects of interferon-gamma and interleukin-4. Endocrinology. 1994 Jul; 135(1):351-8. PMID: 7516868.
        View in: PubMed
      20. Strewler GJ. Familial benign hypocalciuric hypercalcemia--from the clinic to the calcium sensor. West J Med. 1994 Jun; 160(6):579-80. PMID: 8053190; PMCID: PMC1022575.
      21. Funk JL, Krul EJ, Moser AH, Shigenaga JK, Strewler GJ, Grunfeld C, Feingold KR. Endotoxin increases parathyroid hormone-related protein mRNA levels in mouse spleen. Mediation by tumor necrosis factor. J Clin Invest. 1993 Nov; 92(5):2546-52. PMID: 8227368; PMCID: PMC288441.
      22. Strewler GJ, Budayr AA, Clark OH, Nissenson RA. Production of parathyroid hormone by a malignant nonparathyroid tumor in a hypercalcemic patient. J Clin Endocrinol Metab. 1993 May; 76(5):1373-5. PMID: 7684395.
        View in: PubMed
      23. Marino MT, Asp AA, Budayer AA, Marsden JS, Strewler GJ. Hypercalcaemia and elevated levels of parathyroid hormone-related protein in cutaneous squamous/basal cell carcinoma. J Intern Med. 1993 Feb; 233(2):205-7. PMID: 8433083.
        View in: PubMed
      24. Chan SD, Karpf DB, Fowlkes ME, Hooks M, Bradley MS, Vuong V, Bambino T, Liu MY, Arnaud CD, Strewler GJ. Two homologs of the Drosophila polarity gene frizzled (fz) are widely expressed in mammalian tissues. J Biol Chem. 1992 Dec 15; 267(35):25202-7. PMID: 1334084.
        View in: PubMed
      25. Strewler GJ, Chan SD, Globus RK, Schermer DT, Nissenson RA. Actions of parathyroid hormone-related protein as an embryonic differentiation factor. J Endocrinol Invest. 1992; 15(9 Suppl 6):57-62. PMID: 1300340.
        View in: PubMed
      26. Klein RF, Nissenson RA, Strewler GJ. Pertussis toxin inhibits hormonal stimulation of bone resorption in fetal rat limb bones. J Pharmacol Exp Ther. 1991 Sep; 258(3):877-81. PMID: 1653845.
        View in: PubMed
      27. Schermer DT, Chan SD, Bruce R, Nissenson RA, Wood WI, Strewler GJ. Chicken parathyroid hormone-related protein and its expression during embryologic development. J Bone Miner Res. 1991 Feb; 6(2):149-55. PMID: 1709333.
        View in: PubMed
      28. Cohen FE, Strewler GJ, Bradley MS, Carlquist M, Nilsson M, Ericsson M, Ciardelli TL, Nissenson RA. Analogues of parathyroid hormone modified at positions 3 and 6. Effects on receptor binding and activation of adenylyl cyclase in kidney and bone. J Biol Chem. 1991 Jan 25; 266(3):1997-2004. PMID: 1846369.
        View in: PubMed
      29. Strewler GJ, Nissenson RA. Hypercalcemia in malignancy. West J Med. 1990 Dec; 153(6):635-40. PMID: 2293469; PMCID: PMC1002641.
      30. Chan SD, Strewler GJ, Nissenson RA. Transcriptional activation of Gs alpha expression by retinoic acid and parathyroid hormone-related protein in F9 teratocarcinoma cells. J Biol Chem. 1990 Nov 25; 265(33):20081-4. PMID: 2122968.
        View in: PubMed
      31. Chan SD, Strewler GJ, King KL, Nissenson RA. Expression of a parathyroid hormone-like protein and its receptor during differentiation of embryonal carcinoma cells. Mol Endocrinol. 1990 Apr; 4(4):638-46. PMID: 2177844.
        View in: PubMed
      32. Strewler GJ, Nissenson RA. Peptide mediators of hypercalcemia in malignancy. Annu Rev Med. 1990; 41:35-44. PMID: 2184736.
        View in: PubMed
      33. Budayr AA, Nissenson RA, Klein RF, Pun KK, Clark OH, Diep D, Arnaud CD, Strewler GJ. Increased serum levels of a parathyroid hormone-like protein in malignancy-associated hypercalcemia. Ann Intern Med. 1989 Nov 15; 111(10):807-12. PMID: 2817628.
        View in: PubMed
      34. Budayr AA, Halloran BP, King JC, Diep D, Nissenson RA, Strewler GJ. High levels of a parathyroid hormone-like protein in milk. Proc Natl Acad Sci U S A. 1989 Sep; 86(18):7183-5. PMID: 2550932; PMCID: PMC298020.
      35. Nissenson RA, Diep D, Strewler GJ. Synthetic peptides comprising the amino-terminal sequence of a parathyroid hormone-like protein from human malignancies. Binding to parathyroid hormone receptors and activation of adenylate cyclase in bone cells and kidney. J Biol Chem. 1988 Sep 15; 263(26):12866-71. PMID: 2843501.
        View in: PubMed
      36. Thiede MA, Strewler GJ, Nissenson RA, Rosenblatt M, Rodan GA. Human renal carcinoma expresses two messages encoding a parathyroid hormone-like peptide: evidence for the alternative splicing of a single-copy gene. Proc Natl Acad Sci U S A. 1988 Jul; 85(13):4605-9. PMID: 3290897; PMCID: PMC280483.
      37. Klein RF, Nissenson RA, Strewler GJ. Forskolin mimics the effects of calcitonin but not parathyroid hormone on bone resorption in vitro. Bone Miner. 1988 Jul; 4(3):247-56. PMID: 2847839.
        View in: PubMed
      38. Strewler GJ, Stern PH, Jacobs JW, Eveloff J, Klein RF, Leung SC, Rosenblatt M, Nissenson RA. Parathyroid hormonelike protein from human renal carcinoma cells. Structural and functional homology with parathyroid hormone. J Clin Invest. 1987 Dec; 80(6):1803-7. PMID: 3680530; PMCID: PMC442457.
      39. Klein RF, Strewler GJ, Leung SC, Nissenson RA. Parathyroid hormone-like adenylate cyclase-stimulating activity from a human carcinoma is associated with bone-resorbing activity. Endocrinology. 1987 Feb; 120(2):504-11. PMID: 3026777.
        View in: PubMed
      40. Strewler GJ, Nissenson RA. Nonparathyroid hypercalcemia. Adv Intern Med. 1987; 32:235-58. PMID: 3030065.
        View in: PubMed
      41. Strewler GJ, Wronski TJ, Halloran BP, Miller SC, Leung SC, Williams RD, Nissenson RA. Pathogenesis of hypercalcemia in nude mice bearing a human renal carcinoma. Endocrinology. 1986 Jul; 119(1):303-10. PMID: 3013591.
        View in: PubMed
      42. Pollock AS, Warnock DG, Strewler GJ. Parathyroid hormone inhibition of Na+-H+ antiporter activity in a cultured renal cell line. Am J Physiol. 1986 Feb; 250(2 Pt 2):F217-25. PMID: 2418691.
        View in: PubMed
      43. Stern PH, Krieger NS, Nissenson RA, Williams RD, Winkler ME, Derynck R, Strewler GJ. Human transforming growth factor-alpha stimulates bone resorption in vitro. J Clin Invest. 1985 Nov; 76(5):2016-9. PMID: 3877079; PMCID: PMC424268.
      44. Nissenson RA, Strewler GJ, Williams RD, Leung SC. Activation of the parathyroid hormone receptor-adenylate cyclase system in osteosarcoma cells by a human renal carcinoma factor. Cancer Res. 1985 Nov; 45(11 Pt 1):5358-63. PMID: 2996759.
        View in: PubMed
      45. Bikle DD, Genant HK, Cann C, Recker RR, Halloran BP, Strewler GJ. Bone disease in alcohol abuse. Ann Intern Med. 1985 Jul; 103(1):42-8. PMID: 2988390.
        View in: PubMed
      46. Pollock AS, Strewler GJ, Miller RT, Lawlor D, Horowitz DD, Warnock DG. Biologic regulation of Na/H antiporter activity in a cultured kidney cell line: effects of parathyroid hormone (PTH). Ann N Y Acad Sci. 1985; 456:451-3. PMID: 3867312.
        View in: PubMed
      47. Strewler GJ. Paget's disease of bone. West J Med. 1984 May; 140(5):763-8. PMID: 6730492; PMCID: PMC1011083.
      48. Strewler GJ. Release of cAMP from a renal epithelial cell line. Am J Physiol. 1984 Mar; 246(3 Pt 1):C224-30. PMID: 6322592.
        View in: PubMed
      49. Teitelbaum AP, Strewler GJ. Parathyroid hormone receptors coupled to cyclic adenosine monophosphate formation in an established renal cell line. Endocrinology. 1984 Mar; 114(3):980-5. PMID: 6321147.
        View in: PubMed
      50. Gogel E, Halloran BP, Strewler GJ. Probenecid inhibits the secretion of nephrogenous adenosine 3',5'-monophosphate in normal man. J Clin Endocrinol Metab. 1983 Oct; 57(4):689-93. PMID: 6309880.
        View in: PubMed
      51. Strewler GJ, Danello MA, Manganiello VC, Vaughan M. Ca2+-independent cyclic GMP phosphodiesterases from rat liver and HTC hepatoma cells. Biochem J. 1983 Aug 1; 213(2):379-86. PMID: 6311163; PMCID: PMC1152138.
      52. Strewler GJ, Williams RD, Nissenson RA. Human renal carcinoma cells produce hypercalcemia in the nude mouse and a novel protein recognized by parathyroid hormone receptors. J Clin Invest. 1983 Mar; 71(3):769-74. PMID: 6298282; PMCID: PMC436928.
      53. Strewler GJ, Fallon BG, Orloff J. Defective protein phosphorylation in renal medulla of vasopressin-resistant mice. Biochem Biophys Res Commun. 1981 Nov 30; 103(2):713-20. PMID: 7332566.
        View in: PubMed
      54. Vaughan M, Danello MA, Manganiello VC, Strewler GJ. Regulation of cyclic nucleotide phosphodiesterase activity. Adv Cyclic Nucleotide Res. 1981; 14:263-71. PMID: 6169258.
        View in: PubMed
      55. Strewler GJ, Manganiello VC. Purification and characterization of phosphodiesterase activator from kidney. A lysosomal protease. J Biol Chem. 1979 Dec 10; 254(23):11891-8. PMID: 227882.
        View in: PubMed
      56. Pinkett MO, Strewler GJ, Anderson WB. Stimulation of adenylate cyclase activity by a protease which activates cyclic nucleotide phosphodiesterase. Biochem Biophys Res Commun. 1979 Oct 29; 90(4):1159-65. PMID: 229831.
        View in: PubMed
      57. Strewler GJ, Manganiello VC, Vaughan M. Phosphodiesterase activator from rat kidney cortex. J Biol Chem. 1978 Jan 25; 253(2):390-4. PMID: 201632.
        View in: PubMed
      58. Strewler GJ, Orloff J. Role of cyclic nucleotides in the transport of water and electrolytes. Adv Cyclic Nucleotide Res. 1977; 8:311-61. PMID: 200128.
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      59. Eastman RC, Come SE, Strewler GJ, Gorden P, Kahn CR. Adriamycin therapy for advanced insulinoma. J Clin Endocrinol Metab. 1977 Jan; 44(1):142-8. PMID: 188859.
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      60. Rothman IK, Alter HJ, Strewler GJ. Delayed overt hemolytic transfusion reaction due to anti-U antibody. Transfusion. 1976 Jul-Aug; 16(4):357-60. PMID: 951732.
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      61. Strewler GJ, Bernstein DS, Pletka P. Pseudo-vitamin D deficiency rickets (PDR) and relative hypoparathyroidism: a report of a family. J Clin Endocrinol Metab. 1973 Aug; 37(2):220-9. PMID: 4720069.
        View in: PubMed
      62. Strewler GJ, Hinrichs KJ, Guiod LR, Hollenberg NK. Sodium intake and vascular smooth muscle responsiveness to norepinephrine and angiotensin in the rabbit. Circ Res. 1972 Nov; 31(5):758-66. PMID: 4343577.
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      63. Woods BT, Strewler GJ. Hemiparesis occurring six hours after intravenous heroin injection. Neurology. 1972 Aug; 22(8):863-6. PMID: 4673415.
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      64. Wade DN, Desbiens N, Strewler GJ, Berndt WO, Mudge GH. Metabolism of iophenoxic acid in the dog. J Pharmacol Exp Ther. 1971 Jul; 178(1):173-9. PMID: 5087395.
        View in: PubMed
      65. Mudge GH, Strewler GJ, Desbiens N, Berndt WO, Wade DN. Excretion and distribution of iophenoxic acid. J Pharmacol Exp Ther. 1971 Jul; 178(1):159-72. PMID: 5087394.
        View in: PubMed
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