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    Caroline Damsky, PhD

    TitleProfessor
    SchoolUCSF School of Dentistry
    DepartmentCell and Tissue Biology
    Address513 Parnassus Ave, Med Sci
    San Francisco CA 94143
    Phone415-476-8922
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Kim JB, Leucht P, Luppen CA, Park YJ, Beggs HE, Damsky CH, Helms JA. Reconciling the roles of FAK in osteoblast differentiation, osteoclast remodeling, and bone regeneration. Bone. 2007 Jul; 41(1):39-51. PMID: 17459803; PMCID: PMC2699353.
      2. Damsky C. Interview with Caroline Damsky. J Cell Sci. 2004 Aug 1; 117(Pt 17):3713-4. PMID: 15286172.
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      3. Ilic D, Kovacic B, Johkura K, Schlaepfer DD, Tomasevic N, Han Q, Kim JB, Howerton K, Baumbusch C, Ogiwara N, Streblow DN, Nelson JA, Dazin P, Shino Y, Sasaki K, Damsky CH. FAK promotes organization of fibronectin matrix and fibrillar adhesions. J Cell Sci. 2004 Jan 15; 117(Pt 2):177-87. PMID: 14657279.
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      4. Ilic D, Kovacic B, McDonagh S, Jin F, Baumbusch C, Gardner DG, Damsky CH. Focal adhesion kinase is required for blood vessel morphogenesis. Circ Res. 2003 Feb 21; 92(3):300-7. PMID: 12595342.
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      5. Damsky CH, Ilic D. Integrin signaling: it's where the action is. Curr Opin Cell Biol. 2002 Oct; 14(5):594-602. PMID: 12231355.
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      6. Kamiya N, Jikko A, Kimata K, Damsky C, Shimizu K, Watanabe H. Establishment of a novel chondrocytic cell line N1511 derived from p53-null mice. J Bone Miner Res. 2002 Oct; 17(10):1832-42. PMID: 12369787.
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      7. Damsky C. Cell-cell and cell-extracellular matrix adhesion receptors. Ann N Y Acad Sci. 2002 Jun; 961:154-5. PMID: 12081885.
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      8. Damsky C, Heidaran M, Bottaro D, Crossin K, Ducy P, Ingber D. Molecular signaling: breakout session summary. Ann N Y Acad Sci. 2002 Jun; 961:164-7. PMID: 12081891.
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      9. Zhou Y, McMaster M, Woo K, Janatpour M, Perry J, Karpanen T, Alitalo K, Damsky C, Fisher SJ. Vascular endothelial growth factor ligands and receptors that regulate human cytotrophoblast survival are dysregulated in severe preeclampsia and hemolysis, elevated liver enzymes, and low platelets syndrome. Am J Pathol. 2002 Apr; 160(4):1405-23. PMID: 11943725; PMCID: PMC3277330.
      10. Graus-Porta D, Blaess S, Senften M, Littlewood-Evans A, Damsky C, Huang Z, Orban P, Klein R, Schittny JC, Müller U. Beta1-class integrins regulate the development of laminae and folia in the cerebral and cerebellar cortex. Neuron. 2001 Aug 16; 31(3):367-79. PMID: 11516395.
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      11. Kovacic-Milivojevic B, Roediger F, Almeida EA, Damsky CH, Gardner DG, Ilic D. Focal adhesion kinase and p130Cas mediate both sarcomeric organization and activation of genes associated with cardiac myocyte hypertrophy. Mol Biol Cell. 2001 Aug; 12(8):2290-307. PMID: 11514617; PMCID: PMC58595.
      12. Ilic D, Genbacev O, Jin F, Caceres E, Almeida EA, Bellingard-Dubouchaud V, Schaefer EM, Damsky CH, Fisher SJ. Plasma membrane-associated pY397FAK is a marker of cytotrophoblast invasion in vivo and in vitro. Am J Pathol. 2001 Jul; 159(1):93-108. PMID: 11438458; PMCID: PMC1850415.
      13. Almeida EA, Ilic D, Han Q, Hauck CR, Jin F, Kawakatsu H, Schlaepfer DD, Damsky CH. Matrix survival signaling: from fibronectin via focal adhesion kinase to c-Jun NH(2)-terminal kinase. J Cell Biol. 2000 May 1; 149(3):741-54. PMID: 10791986; PMCID: PMC2174844.
      14. Sieg DJ, Hauck CR, Ilic D, Klingbeil CK, Schaefer E, Damsky CH, Schlaepfer DD. FAK integrates growth-factor and integrin signals to promote cell migration. Nat Cell Biol. 2000 May; 2(5):249-56. PMID: 10806474.
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      15. Zimmerman D, Jin F, Leboy P, Hardy S, Damsky C. Impaired bone formation in transgenic mice resulting from altered integrin function in osteoblasts. Dev Biol. 2000 Apr 1; 220(1):2-15. PMID: 10720426.
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      16. Suen PW, Ilic D, Caveggion E, Berton G, Damsky CH, Lowell CA. Impaired integrin-mediated signal transduction, altered cytoskeletal structure and reduced motility in Hck/Fgr deficient macrophages. J Cell Sci. 1999 Nov; 112 ( Pt 22):4067-78. PMID: 10547366.
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      17. Damsky CH. Extracellular matrix-integrin interactions in osteoblast function and tissue remodeling. Bone. 1999 Jul; 25(1):95-6. PMID: 10423030.
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      18. Jikko A, Harris SE, Chen D, Mendrick DL, Damsky CH. Collagen integrin receptors regulate early osteoblast differentiation induced by BMP-2. J Bone Miner Res. 1999 Jul; 14(7):1075-83. PMID: 10404007.
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      19. Kovacic B, Ilic D, Damsky CH, Gardner DG. c-Src activation plays a role in endothelin-dependent hypertrophy of the cardiac myocyte. J Biol Chem. 1998 Dec 25; 273(52):35185-93. PMID: 9857056.
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      20. Ilic D, Almeida EA, Schlaepfer DD, Dazin P, Aizawa S, Damsky CH. Extracellular matrix survival signals transduced by focal adhesion kinase suppress p53-mediated apoptosis. J Cell Biol. 1998 Oct 19; 143(2):547-60. PMID: 9786962; PMCID: PMC2132850.
      21. Sieg DJ, Ilic D, Jones KC, Damsky CH, Hunter T, Schlaepfer DD. Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK- cell migration. EMBO J. 1998 Oct 15; 17(20):5933-47. PMID: 9774338; PMCID: PMC1170921.
      22. Damsky CH, Fisher SJ. Trophoblast pseudo-vasculogenesis: faking it with endothelial adhesion receptors. Curr Opin Cell Biol. 1998 Oct; 10(5):660-6. PMID: 9818178.
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      23. Zhou Y, Genbacev O, Damsky CH, Fisher SJ. Oxygen regulates human cytotrophoblast differentiation and invasion: implications for endovascular invasion in normal pregnancy and in pre-eclampsia. J Reprod Immunol. 1998 Aug; 39(1-2):197-213. PMID: 9786462.
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      24. Globus RK, Doty SB, Lull JC, Holmuhamedov E, Humphries MJ, Damsky CH. Fibronectin is a survival factor for differentiated osteoblasts. J Cell Sci. 1998 May; 111 ( Pt 10):1385-93. PMID: 9570756.
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      25. Moursi AM, Globus RK, Damsky CH. Interactions between integrin receptors and fibronectin are required for calvarial osteoblast differentiation in vitro. J Cell Sci. 1997 Sep; 110 ( Pt 18):2187-96. PMID: 9378768.
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      26. Damsky CH, Moursi A, Zhou Y, Fisher SJ, Globus RK. The solid state environment orchestrates embryonic development and tissue remodeling. Kidney Int. 1997 May; 51(5):1427-33. PMID: 9150454.
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      27. Zhou Y, Damsky CH, Fisher SJ. Preeclampsia is associated with failure of human cytotrophoblasts to mimic a vascular adhesion phenotype. One cause of defective endovascular invasion in this syndrome? J Clin Invest. 1997 May 1; 99(9):2152-64. PMID: 9151787; PMCID: PMC508045.
      28. Zhou Y, Fisher SJ, Janatpour M, Genbacev O, Dejana E, Wheelock M, Damsky CH. Human cytotrophoblasts adopt a vascular phenotype as they differentiate. A strategy for successful endovascular invasion? J Clin Invest. 1997 May 1; 99(9):2139-51. PMID: 9151786; PMCID: PMC508044.
      29. McClay DR, Damsky CH, Bronner-Fraser M, Wylie C, Bernfield M, Markwald RR. NIEHS/EPA Workshops. Cellular migration. Reprod Toxicol. 1997 Mar-Jun; 11(2-3):321-9. PMID: 9100307.
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      30. Ilic D, Damsky CH, Yamamoto T. Focal adhesion kinase: at the crossroads of signal transduction. J Cell Sci. 1997 Feb; 110 ( Pt 4):401-7. PMID: 9067592.
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      31. Huttenlocher A, Werb Z, Tremble P, Huhtala P, Rosenberg L, Damsky CH. Decorin regulates collagenase gene expression in fibroblasts adhering to vitronectin. Matrix Biol. 1996 Sep; 15(4):239-50. PMID: 8892224.
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      32. Logan SK, Hansell EJ, Damsky CH, Werb Z. T-antigen inhibits metalloproteinase expression and invasion in human placental cells transformed with temperature-sensitive simian virus 40. Matrix Biol. 1996 Jul; 15(2):81-9. PMID: 8837009.
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      33. Moursi AM, Damsky CH, Lull J, Zimmerman D, Doty SB, Aota S, Globus RK. Fibronectin regulates calvarial osteoblast differentiation. J Cell Sci. 1996 Jun; 109 ( Pt 6):1369-80. PMID: 8799825.
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      34. Xia M, Sreedharan SP, Dazin P, Damsky CH, Goetzl EJ. Integrin-dependent role of human T cell matrix metalloproteinase activity in chemotaxis through a model basement membrane. J Cell Biochem. 1996 Jun 1; 61(3):452-8. PMID: 8761949.
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      35. Genbacev O, Joslin R, Damsky CH, Polliotti BM, Fisher SJ. Hypoxia alters early gestation human cytotrophoblast differentiation/invasion in vitro and models the placental defects that occur in preeclampsia. J Clin Invest. 1996 Jan 15; 97(2):540-50. PMID: 8567979; PMCID: PMC507049.
      36. Globus RK, Moursi A, Zimmerman D, Lull J, Damsky C. Integrin-extracellular matrix interactions in connective tissue remodeling and osteoblast differentiation. ASGSB Bull. 1995 Oct; 8(2):19-28. PMID: 11538547.
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      37. Stephens LE, Sutherland AE, Klimanskaya IV, Andrieux A, Meneses J, Pedersen RA, Damsky CH. Deletion of beta 1 integrins in mice results in inner cell mass failure and peri-implantation lethality. Genes Dev. 1995 Aug 1; 9(15):1883-95. PMID: 7544312.
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      38. Filardo EJ, Brooks PC, Deming SL, Damsky C, Cheresh DA. Requirement of the NPXY motif in the integrin beta 3 subunit cytoplasmic tail for melanoma cell migration in vitro and in vivo. J Cell Biol. 1995 Jul; 130(2):441-50. PMID: 7542248; PMCID: PMC2199943.
      39. Tremble P, Damsky CH, Werb Z. Components of the nuclear signaling cascade that regulate collagenase gene expression in response to integrin-derived signals. J Cell Biol. 1995 Jun; 129(6):1707-20. PMID: 7790365; PMCID: PMC2291183.
      40. Howlett AR, Bailey N, Damsky C, Petersen OW, Bissell MJ. Cellular growth and survival are mediated by beta 1 integrins in normal human breast epithelium but not in breast carcinoma. J Cell Sci. 1995 May; 108 ( Pt 5):1945-57. PMID: 7544798.
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      41. Huhtala P, Humphries MJ, McCarthy JB, Tremble PM, Werb Z, Damsky CH. Cooperative signaling by alpha 5 beta 1 and alpha 4 beta 1 integrins regulates metalloproteinase gene expression in fibroblasts adhering to fibronectin. J Cell Biol. 1995 May; 129(3):867-79. PMID: 7537277; PMCID: PMC2120442.
      42. McMaster MT, Librach CL, Zhou Y, Lim KH, Janatpour MJ, DeMars R, Kovats S, Damsky C, Fisher SJ. Human placental HLA-G expression is restricted to differentiated cytotrophoblasts. J Immunol. 1995 Apr 15; 154(8):3771-8. PMID: 7706718.
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      43. Damsky CH, Librach C, Lim KH, Fitzgerald ML, McMaster MT, Janatpour M, Zhou Y, Logan SK, Fisher SJ. Integrin switching regulates normal trophoblast invasion. Development. 1994 Dec; 120(12):3657-66. PMID: 7529679.
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      44. Moss L, Prakobphol A, Wiedmann TW, Fisher SJ, Damsky CH. Glycosylation of human trophoblast integrins is stage and cell-type specific. Glycobiology. 1994 Oct; 4(5):567-75. PMID: 7881170.
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      45. Stephens LE, Sonne JE, Fitzgerald ML, Damsky CH. Targeted deletion of beta 1 integrins in F9 embryonal carcinoma cells affects morphological differentiation but not tissue-specific gene expression. J Cell Biol. 1993 Dec; 123(6 Pt 1):1607-20. PMID: 7504677; PMCID: PMC2290911.
      46. Sutherland AE, Calarco PG, Damsky CH. Developmental regulation of integrin expression at the time of implantation in the mouse embryo. Development. 1993 Dec; 119(4):1175-86. PMID: 8306881.
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      47. Damsky C, Sutherland A, Fisher S. Extracellular matrix 5: adhesive interactions in early mammalian embryogenesis, implantation, and placentation. FASEB J. 1993 Nov; 7(14):1320-9. PMID: 8224605.
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      48. Tomaselli KJ, Doherty P, Emmett CJ, Damsky CH, Walsh FS, Reichardt LF. Expression of beta 1 integrins in sensory neurons of the dorsal root ganglion and their functions in neurite outgrowth on two laminin isoforms. J Neurosci. 1993 Nov; 13(11):4880-8. PMID: 7693896; PMCID: PMC2710121.
      49. Burdsal CA, Damsky CH, Pedersen RA. The role of E-cadherin and integrins in mesoderm differentiation and migration at the mammalian primitive streak. Development. 1993 Jul; 118(3):829-44. PMID: 7521282.
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      50. Fisher SJ, Damsky CH. Human cytotrophoblast invasion. Semin Cell Biol. 1993 Jun; 4(3):183-8. PMID: 8347835.
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      51. Thomas L, Chan PW, Chang S, Damsky C. 5-Bromo-2-deoxyuridine regulates invasiveness and expression of integrins and matrix-degrading proteinases in a differentiated hamster melanoma cell. J Cell Sci. 1993 May; 105 ( Pt 1):191-201. PMID: 8360273.
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      52. Zhou Y, Damsky CH, Chiu K, Roberts JM, Fisher SJ. Preeclampsia is associated with abnormal expression of adhesion molecules by invasive cytotrophoblasts. J Clin Invest. 1993 Mar; 91(3):950-60. PMID: 7680671; PMCID: PMC288047.
      53. Logan SK, Fisher SJ, Damsky CH. Human placental cells transformed with temperature-sensitive simian virus 40 are immortalized and mimic the phenotype of invasive cytotrophoblasts at both permissive and nonpermissive temperatures. Cancer Res. 1992 Nov 1; 52(21):6001-9. PMID: 1327521.
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      54. Damsky CH, Werb Z. Signal transduction by integrin receptors for extracellular matrix: cooperative processing of extracellular information. Curr Opin Cell Biol. 1992 Oct; 4(5):772-81. PMID: 1329869.
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      55. Arrick BA, Lopez AR, Elfman F, Ebner R, Damsky CH, Derynck R. Altered metabolic and adhesive properties and increased tumorigenesis associated with increased expression of transforming growth factor beta 1. J Cell Biol. 1992 Aug; 118(3):715-26. PMID: 1639853; PMCID: PMC2289543.
      56. Tournier JM, Goldstein GA, Hall DE, Damsky CH, Basbaum CB. Extracellular matrix proteins regulate morphologic and biochemical properties of tracheal gland serous cells through integrins. Am J Respir Cell Mol Biol. 1992 May; 6(5):461-71. PMID: 1316131.
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      57. Damsky CH, Fitzgerald ML, Fisher SJ. Distribution patterns of extracellular matrix components and adhesion receptors are intricately modulated during first trimester cytotrophoblast differentiation along the invasive pathway, in vivo. J Clin Invest. 1992 Jan; 89(1):210-22. PMID: 1370295; PMCID: PMC442839.
      58. Tremble PM, Damsky CH, Werb Z. Fibronectin fragments, but not intact fibronectin, signalling through the fibronectin receptor induce metalloproteinase gene expression in fibroblasts. Matrix Suppl. 1992; 1:212-4. PMID: 1480029.
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      59. Damsky C, Tremble P, Werb Z. Signal transduction via the fibronectin receptor: do integrins regulate matrix remodeling? Matrix Suppl. 1992; 1:184-91. PMID: 1282660.
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      60. Sutherland AE, Sanderson RD, Mayes M, Seibert M, Calarco PG, Bernfield M, Damsky CH. Expression of syndecan, a putative low affinity fibroblast growth factor receptor, in the early mouse embryo. Development. 1991 Sep; 113(1):339-51. PMID: 1765004.
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      61. Librach CL, Werb Z, Fitzgerald ML, Chiu K, Corwin NM, Esteves RA, Grobelny D, Galardy R, Damsky CH, Fisher SJ. 92-kD type IV collagenase mediates invasion of human cytotrophoblasts. J Cell Biol. 1991 Apr; 113(2):437-49. PMID: 1849141; PMCID: PMC2288933.
      62. Werb Z, Tremble P, Damsky CH. Regulation of extracellular matrix degradation by cell-extracellular matrix interactions. Cell Differ Dev. 1990 Dec 2; 32(3):299-306. PMID: 2151566.
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      63. Watson AJ, Damsky CH, Kidder GM. Differentiation of an epithelium: factors affecting the polarized distribution of Na+,K(+)-ATPase in mouse trophectoderm. Dev Biol. 1990 Sep; 141(1):104-14. PMID: 2167855.
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      64. Hall DE, Reichardt LF, Crowley E, Holley B, Moezzi H, Sonnenberg A, Damsky CH. The alpha 1/beta 1 and alpha 6/beta 1 integrin heterodimers mediate cell attachment to distinct sites on laminin. J Cell Biol. 1990 Jun; 110(6):2175-84. PMID: 2351695; PMCID: PMC2116113.
      65. Bohnsack JF, Akiyama SK, Damsky CH, Knape WA, Zimmerman GA. Human neutrophil adherence to laminin in vitro. Evidence for a distinct neutrophil integrin receptor for laminin. J Exp Med. 1990 Apr 1; 171(4):1221-37. PMID: 1969920; PMCID: PMC2187840.
      66. Werb Z, Tremble PM, Behrendtsen O, Crowley E, Damsky CH. Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression. J Cell Biol. 1989 Aug; 109(2):877-89. PMID: 2547805; PMCID: PMC2115739.
      67. Fisher SJ, Cui TY, Zhang L, Hartman L, Grahl K, Zhang GY, Tarpey J, Damsky CH. Adhesive and degradative properties of human placental cytotrophoblast cells in vitro. J Cell Biol. 1989 Aug; 109(2):891-902. PMID: 2474556; PMCID: PMC2115717.
      68. Kramer RH, McDonald KA, Crowley E, Ramos DM, Damsky CH. Melanoma cell adhesion to basement membrane mediated by integrin-related complexes. Cancer Res. 1989 Jan 15; 49(2):393-402. PMID: 2535959.
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      69. Tomaselli KJ, Damsky CH, Reichardt LF. Purification and characterization of mammalian integrins expressed by a rat neuronal cell line (PC12): evidence that they function as alpha/beta heterodimeric receptors for laminin and type IV collagen. J Cell Biol. 1988 Sep; 107(3):1241-52. PMID: 2843550; PMCID: PMC2115278.
      70. Sutherland AE, Calarco PG, Damsky CH. Expression and function of cell surface extracellular matrix receptors in mouse blastocyst attachment and outgrowth. J Cell Biol. 1988 Apr; 106(4):1331-48. PMID: 2834405; PMCID: PMC2115031.
      71. Damjanov I, Damjanov A, Damsky CH. Developmentally regulated expression of the cell-cell adhesion glycoprotein cell-CAM 120/80 in peri-implantation mouse embryos and extraembryonic membranes. Dev Biol. 1986 Jul; 116(1):194-202. PMID: 3525276.
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      72. Damsky CH, Knudsen KA, Bradley D, Buck CA, Horwitz AF. Distribution of the cell substratum attachment (CSAT) antigen on myogenic and fibroblastic cells in culture. J Cell Biol. 1985 May; 100(5):1528-39. PMID: 3921554; PMCID: PMC2113851.
      73. Richa J, Damsky CH, Buck CA, Knowles BB, Solter D. Cell surface glycoproteins mediate compaction, trophoblast attachment, and endoderm formation during early mouse development. Dev Biol. 1985 Apr; 108(2):513-21. PMID: 4076542.
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      74. Giancotti FG, Tarone G, Knudsen K, Damsky C, Comoglio PM. Cleavage of a 135 kD cell surface glycoprotein correlates with loss of fibroblast adhesion to fibronectin. Exp Cell Res. 1985 Jan; 156(1):182-90. PMID: 2981173.
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      75. Damsky CH, Richa J, Solter D, Knudsen K, Buck CA. Identification and purification of a cell surface glycoprotein mediating intercellular adhesion in embryonic and adult tissue. Cell. 1983 Sep; 34(2):455-66. PMID: 6352050.
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