Charles Kim, PhD
|School||UCSF School of Medicine|
|Address||1001 Potrero Ave|
San Francisco CA 94110
|University of California, San Francisco||Postdoctoral Studies||Graduate Division|
Despite over a century of research since the discovery of Plasmodium parasites, malaria continues to be one of the top causes of infectious mortality in the world. An effective vaccine could significantly reduce malaria prevalence, but our lack of understanding of immune control mechanisms hinders the rational design of such a tool. To advance us toward this goal, we wish to understand how malaria infection is recognized by the host immune system, and how these recognition events subsequently promote activation of immune responses responsible for parasite elimination.
We are employing a combination of immunology and systems biology approaches to understand these processes in the Plasmodium chabaudi mouse model of malaria infection. Our current interests are focused on the discovery of novel signaling pathways and regulatory network architecture in leukocytes of the innate immune system, combinatorial interactions between these pathways, identifying innate-adaptive interactions, and determining how these intracellular and intercellular interactions combine into a cohesive effector response capable of clearance of malaria parasites.
EDUCATION AND TRAINING
University of Illinois, Urbana-Champaign, BS, 1997
Stanford University, PhD, 2004
University of California, San Francisco, Postdoctoral Fellow, 2005-2011
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