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    Christine Hsieh, PhD

    TitleAssistant Professor
    SchoolUCSF School of Medicine
    DepartmentMedicine
    Address513 Parnassus Ave, Med Sci
    San Francisco CA 94122
    Phone415-221-4810
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      Collapse Biography 
      Collapse Education and Training
      University of California, San FranciscoPostdoctoral FellowshipDepartment of Medicine, Rheumatology Division2010
      Stanford UniversityPh.D.School of Medicine, Immunology Program2006
      University of California, Los AngelesB.S.Molecular, Cell and Developmental Biology 1999
      Collapse Awards and Honors
      Veterans' Administration2015 - 2019VA Biomedical Laboratory Research & Development TBI Merit Review (PI)
      Veterans' Administration2016 - 2020VA Biomedical Laboratory Research & Development Merit Review (Co-I)
      Rheumatology Foundation2015 - 2017Innovation Award (Co-I)
      Veterans' Administration2011 - 2015VA Career Development Award-2 (PI)
      NIH and NINDS2007 - 2009Ruth L. Kirschstein National Research Service Postdoctoral Award
      NIH and UCSF2006 - 2007Postdoctoral Training Award

      Collapse Overview 
      Collapse Overview
      I am interested in understanding immune mechanisms that contribute to inflammation and wound healing during traumatic brain injury and neurodegeneration. I am investigating the roles and heterogeneity of macrophages and microglia during traumatic brain injury. My goal is to identify therapeutic avenues to shape the immune response to improve outcomes of traumatic brain injury and other neurodegenerative disorders.

      Collapse Interests
      Innate immunity, brain injury, TBI, neuroinflammation, immunology, neurodegeneration, monocyte, macrophage, microglia, flow cytometry, polarization, transcriptomics, cardiac injury

      Collapse ORNG Applications 
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      Collapse Featured Publications

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Bucay N, Sekhon K, Yang T, Majid S, Shahryari V, Hsieh CL, Mitsui Y, Deng G, Tabatabai ZL, Yamamura S, Calin G, Dahiya R, Tanaka Y and Saini S. . MicroRNA-383 located in frequently deleted chromosomal locus 8p22 regulates CD44 in prostate cancer. Oncogene. 2016.
      2. Bucay N, Sekhon K, Yang T, Majid S, Shahryari V, Hsieh C, Mitsui Y, Deng G, Tabatabai ZL, Yamamura S, Calin GA, Dahiya R, Tanaka Y, Saini S. MicroRNA-383 located in frequently deleted chromosomal locus 8p22 regulates CD44 in prostate cancer. Oncogene. 2016 Nov 28. PMID: 27893706.
        View in: PubMed
      3. Kim CC, Nakamura MC, Hsieh CL. Brain trauma elicits non-canonical macrophage activation states. J Neuroinflammation. 2016; 13(1):117. PMID: 27220367.
        View in: PubMed
      4. Lui H, Zhang J, Makinson SR, Cahill MK, Kelley KW, Huang HY, Shang Y, Oldham MC, Martens LH, Gao F, Coppola G, Sloan SA, Hsieh CL, Kim CC, Bigio EH, Weintraub S, Mesulam MM, Rademakers R, Mackenzie IR, Seeley WW, Karydas A, Miller BL, Borroni B, Ghidoni R, Farese RV, Paz JT, Barres BA, Huang EJ. Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation. Cell. 2016 May 5; 165(4):921-35. PMID: 27114033.
        View in: PubMed
      5. Kawabori M, Kacimi R, Kauppinen T, Calosing C, Kim JY, Hsieh CL, Nakamura MC, Yenari MA. Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke. J Neurosci. 2015 Feb 25; 35(8):3384-96. PMID: 25716838; PMCID: PMC4339351.
      6. Hsieh CL, Niemi EC, Wang SH, Lee CC, Bingham D, Zhang J, Cozen ML, Charo I, Huang EJ, Liu J, Nakamura MC. CCR2 deficiency impairs macrophage infiltration and improves cognitive function after traumatic brain injury. J Neurotrauma. 2014 Oct 15; 31(20):1677-88. PMID: 24806994; PMCID: PMC4545982.
      7. Kawabori M, Hokari M, Zheng Z, Kim JY, Calosing C, Hsieh CL, Nakamura MC, Yenari MA. Triggering Receptor Expressed on Myeloid Cells-2 Correlates to Hypothermic Neuroprotection in Ischemic Stroke. Ther Hypothermia Temp Manag. 2013 Dec 1; 3(4):189-198. PMID: 24380032.
        View in: PubMed
      8. Hsieh CL, Kim CC, Ryba BE, Niemi EC, Bando JK, Locksley RM, Liu J, Nakamura MC, Seaman WE. Traumatic brain injury induces macrophage subsets in the brain. Eur J Immunol. 2013 Aug; 43(8):2010-22. PMID: 23630120; PMCID: PMC4210355.
      9. Hsieh CL, Koike M, Spusta SC, Niemi EC, Yenari M, Nakamura MC, Seaman WE. A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia. J Neurochem. 2009 May; 109(4):1144-56. PMID: 19302484; PMCID: PMC3087597.
      10. Hsieh CL, Nagasaki K, Martinez OM, Krams SM. NKp30 is a functional activation receptor on a subset of rat natural killer cells. Eur J Immunol. 2006 Aug; 36(8):2170-80. PMID: 16821237; PMCID: PMC4084722.
      11. Obara H, Nagasaki K, Hsieh CL, Ogura Y, Esquivel CO, Martinez OM, Krams SM. IFN-gamma, produced by NK cells that infiltrate liver allografts early after transplantation, links the innate and adaptive immune responses. Am J Transplant. 2005 Sep; 5(9):2094-103. PMID: 16095488; PMCID: PMC1473982.
      12. Hsieh CL, Ogura Y, Obara H, Ali UA, Rodriguez GM, Nepomuceno RR, Martinez OM, Krams SM. Identification, cloning, and characterization of a novel rat natural killer receptor, RNKP30: a molecule expressed in liver allografts. Transplantation. 2004 Jan 15; 77(1):121-8. PMID: 14724446.
        View in: PubMed
      13. Land KM, Delgadillo-Correa MG, Tachezy J, Vanacova S, Hsieh CL, Sutak R, Johnson PJ. Targeted gene replacement of a ferredoxin gene in Trichomonas vaginalis does not lead to metronidazole resistance. Mol Microbiol. 2004 Jan; 51(1):115-22. PMID: 14651615.
        View in: PubMed
      14. Bradley PJ, Hsieh CL, Boothroyd JC. Unprocessed Toxoplasma ROP1 is effectively targeted and secreted into the nascent parasitophorous vacuole. Mol Biochem Parasitol. 2002 Nov-Dec; 125(1-2):189-93. PMID: 12467986.
        View in: PubMed
      15. Hsieh CL, Obara H, Ogura Y, Martinez OM, Krams SM. NK cells and transplantation. Transpl Immunol. 2002 May; 9(2-4):111-4. PMID: 12180816.
        View in: PubMed
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