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    Christopher Bowman, MD, PhD

    TitleResident Physician
    SchoolUCSF School of Medicine
    DepartmentPathology
    Address505 Parnassus Avenue
    San Francisco CA 94117
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Bowman CJ, Chapin RE. Goldilocks' Determination of What New In Vivo Data are "Just Right" for Different Common Drug Development Scenarios, Part 1. Birth Defects Res B Dev Reprod Toxicol. 2016 Aug; 107(4-5):185-194. PMID: 27601206.
        View in: PubMed
      2. Halpern WG, Ameri M, Bowman CJ, Elwell MR, Mirsky ML, Oliver J, Regan KS, Remick AK, Sutherland VL, Thompson KE, Tremblay C, Yoshida M, Tomlinson L. Scientific and Regulatory Policy Committee Points to Consider Review: Inclusion of Reproductive and Pathology End Points for Assessment of Reproductive and Developmental Toxicity in Pharmaceutical Drug Development. Toxicol Pathol. 2016 Aug; 44(6):789-809. PMID: 27235322.
        View in: PubMed
      3. Campion SN, Han B, Cappon GD, Lewis EM, Kraynov E, Liang H, Bowman CJ. Decreased maternal and fetal cholesterol following maternal bococizumab (anti-PCSK9 monoclonal antibody) administration does not affect rat embryo-fetal development. Regul Toxicol Pharmacol. 2015 Nov; 73(2):562-70. PMID: 26382609.
        View in: PubMed
      4. Thorn M, Hudson AW, Kreeger J, Kawabe TT, Bowman CJ, Collinge M. Evaluation of a novel delayed-type hypersensitivity assay to Candida albicans in adult and neonatal rats. J Immunotoxicol. 2015; 12(4):350-60. PMID: 25412622.
        View in: PubMed
      5. Bowman CJ, Ayer DE, Dynlacht BD. Foxk proteins repress the initiation of starvation-induced atrophy and autophagy programs. Nat Cell Biol. 2014 Dec; 16(12):1202-14. PMID: 25402684; PMCID: PMC4250422.
      6. Butt M, Evans M, Bowman CJ, Cummings T, Oneda S, Shelton D, Zorbas M. Morphologic, stereologic, and morphometric evaluation of the nervous system in young cynomolgus monkeys (Macaca fascicularis) following maternal administration of tanezumab, a monoclonal antibody to nerve growth factor. Toxicol Sci. 2014 Dec; 142(2):463-76. PMID: 25326242.
        View in: PubMed
      7. Bowman CJ, Evans M, Cummings T, Oneda S, Butt M, Hurst S, Gremminger JL, Shelton D, Kamperschroer C, Zorbas M. Developmental toxicity assessment of tanezumab, an anti-nerve growth factor monoclonal antibody, in cynomolgus monkeys (Macaca fascicularis). Reprod Toxicol. 2015 Jun; 53:105-18. PMID: 25461901.
        View in: PubMed
      8. Cheng J, Blum R, Bowman C, Hu D, Shilatifard A, Shen S, Dynlacht BD. A role for H3K4 monomethylation in gene repression and partitioning of chromatin readers. Mol Cell. 2014 Mar 20; 53(6):979-92. PMID: 24656132; PMCID: PMC4031464.
      9. Bowman CJ, Breslin WJ, Connor AV, Martin PL, Moffat GJ, Sivaraman L, Tornesi MB, Chivers S. Placental transfer of Fc-containing biopharmaceuticals across species, an industry survey analysis. Birth Defects Res B Dev Reprod Toxicol. 2013 Dec; 98(6):459-85. PMID: 24391099.
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      10. Giragossian C, Clark T, Piché-Nicholas N, Bowman CJ. Neonatal Fc receptor and its role in the absorption, distribution, metabolism and excretion of immunoglobulin G-based biotherapeutics. Curr Drug Metab. 2013 Sep; 14(7):764-90. PMID: 23952252.
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      11. Blum R, Vethantham V, Bowman C, Rudnicki M, Dynlacht BD. Genome-wide identification of enhancers in skeletal muscle: the role of MyoD1. Genes Dev. 2012 Dec 15; 26(24):2763-79. PMID: 23249738; PMCID: PMC3533080.
      12. Thorn M, Piche-Nicholas N, Stedman D, Davenport SW, Zhang N, Collinge M, Bowman CJ. Embryo-fetal transfer of bevacizumab (Avastin) in the rat over the course of gestation and the impact of neonatal Fc receptor (FcRn) binding. Birth Defects Res B Dev Reprod Toxicol. 2012 Oct; 95(5):363-75. PMID: 22969064.
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      13. Cappon GD, Bowman CJ, Hurtt ME, Grantham LE. Object discrimination reversal as a method to assess cognitive impairment in nonhuman primate enhanced pre- and postnatal developmental (ePPND) studies: statistical power analysis. Birth Defects Res B Dev Reprod Toxicol. 2012 Oct; 95(5):354-62. PMID: 22930561.
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      14. Coburn AM, Cappon GD, Bowman CJ, Stedman DB, Patyna S. Reproductive toxicity assessment of sunitinib, a multitargeted receptor tyrosine kinase inhibitor, in male and female rats. Birth Defects Res B Dev Reprod Toxicol. 2012 Aug; 95(4):267-75. PMID: 22499257.
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      15. Campion SN, Bowman CJ, Cappon GD, Harrison A, Finch GL, Hurtt ME. Developmental toxicity of lersivirine in rabbits when administered throughout organogenesis and when limited to sensitive windows of axial skeletal development. Birth Defects Res B Dev Reprod Toxicol. 2012 Jun; 95(3):250-61. PMID: 22495820.
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      16. Campion SN, Davenport SJ, Nowland WS, Cappon GD, Bowman CJ, Hurtt ME. Sensitive windows of skeletal development in rabbits determined by hydroxyurea exposure at different times throughout gestation. Birth Defects Res B Dev Reprod Toxicol. 2012 Jun; 95(3):238-49. PMID: 22495808.
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      17. Cappon GD, Bowman CJ, Campion SN, Chmielewski G, Hurtt ME, Finch GL, Lewis EM. Developmental toxicity study of lersivirine in mice. Birth Defects Res B Dev Reprod Toxicol. 2012 Jun; 95(3):225-30. PMID: 22447726.
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      18. DeSesso JM, Williams AL, Ahuja A, Bowman CJ, Hurtt ME. The placenta, transfer of immunoglobulins, and safety assessment of biopharmaceuticals in pregnancy. Crit Rev Toxicol. 2012 Mar; 42(3):185-210. PMID: 22348352.
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      19. Cross DM, Chmielewski G, Lewis EM, Liu L, Modesitt MS, Ripp SL, Sawaryn CM, Bowman CJ. Non-clinical safety assessment and toxicokinetics of voriconazole and anidulafungin in the juvenile rat: a combination study design in support of a Paediatric Investigation Plan. Regul Toxicol Pharmacol. 2012 Jun; 63(1):29-39. PMID: 22343256.
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      20. Ripp SL, Aram JA, Bowman CJ, Chmielewski G, Conte U, Cross DM, Gao H, Lewis EM, Lin J, Liu P, Schlamm HT. Tissue distribution of anidulafungin in neonatal rats. Birth Defects Res B Dev Reprod Toxicol. 2012 Feb; 95(1):89-94. PMID: 22311649.
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      21. Vethantham V, Yang Y, Bowman C, Asp P, Lee JH, Skalnik DG, Dynlacht BD. Dynamic loss of H2B ubiquitylation without corresponding changes in H3K4 trimethylation during myogenic differentiation. Mol Cell Biol. 2012 Mar; 32(6):1044-55. PMID: 22252316; PMCID: PMC3295016.
      22. Chapman KL, Andrews L, Bajramovic JJ, Baldrick P, Black LE, Bowman CJ, Buckley LA, Coney LA, Couch J, Maggie Dempster A, de Haan L, Jones K, Pullen N, de Boer AS, Sims J, Ian Ragan C. The design of chronic toxicology studies of monoclonal antibodies: implications for the reduction in use of non-human primates. Regul Toxicol Pharmacol. 2012 Mar; 62(2):347-54. PMID: 22100994.
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      23. Morford LL, Bowman CJ, Blanset DL, Bøgh IB, Chellman GJ, Halpern WG, Weinbauer GF, Coogan TP. Preclinical safety evaluations supporting pediatric drug development with biopharmaceuticals: strategy, challenges, current practices. Birth Defects Res B Dev Reprod Toxicol. 2011 Aug; 92(4):359-80. PMID: 21770023.
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      24. Bowman CJ, Chmielewski G, Lewis E, Ripp S, Sawaryn CM, Cross DM. Juvenile toxicity assessment of anidulafungin in rats: an example of navigating case-by-case study design through scientific and regulatory challenges. Birth Defects Res B Dev Reprod Toxicol. 2011 Aug; 92(4):333-44. PMID: 21594975.
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      25. Asp P, Blum R, Vethantham V, Parisi F, Micsinai M, Cheng J, Bowman C, Kluger Y, Dynlacht BD. Genome-wide remodeling of the epigenetic landscape during myogenic differentiation. Proc Natl Acad Sci U S A. 2011 May 31; 108(22):E149-58. PMID: 21551099; PMCID: PMC3107312.
      26. van Oevelen C, Bowman C, Pellegrino J, Asp P, Cheng J, Parisi F, Micsinai M, Kluger Y, Chu A, Blais A, David G, Dynlacht BD. The mammalian Sin3 proteins are required for muscle development and sarcomere specification. Mol Cell Biol. 2010 Dec; 30(24):5686-97. PMID: 20956564; PMCID: PMC3004272.
      27. Bowman CJ, Chmielewski G, Oneda S, Finco D, Boucher MA, Todd M. Embryo-fetal developmental toxicity of figitumumab, an anti-insulin-like growth factor-1 receptor (IGF-1R) monoclonal antibody, in cynomolgus monkeys. Birth Defects Res B Dev Reprod Toxicol. 2010 Aug; 89(4):326-38. PMID: 20540090.
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      28. Bowman CJ, Streck RD, Chapin RE. Maternal-placental insulin-like growth factor (IGF) signaling and its importance to normal embryo-fetal development. Birth Defects Res B Dev Reprod Toxicol. 2010 Aug; 89(4):339-49. PMID: 20803692.
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      29. Oztug Durer ZA, Cohlberg JA, Dinh P, Padua S, Ehrenclou K, Downes S, Tan JK, Nakano Y, Bowman CJ, Hoskins JL, Kwon C, Mason AZ, Rodriguez JA, Doucette PA, Shaw BF, Valentine JS. Loss of metal ions, disulfide reduction and mutations related to familial ALS promote formation of amyloid-like aggregates from superoxide dismutase. PLoS One. 2009; 4(3):e5004. PMID: 19325915; PMCID: PMC2659422.
      30. Bowman CJ, Turner KJ, Sar M, Barlow NJ, Gaido KW, Foster PM. Altered gene expression during rat Wolffian duct development following di(n-butyl) phthalate exposure. Toxicol Sci. 2005 Jul; 86(1):161-74. PMID: 15829613.
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      31. Bowman CJ, Barlow NJ, Turner KJ, Wallace DG, Foster PM. Effects of in utero exposure to finasteride on androgen-dependent reproductive development in the male rat. Toxicol Sci. 2003 Aug; 74(2):393-406. PMID: 12773767.
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      32. Turner KJ, McIntyre BS, Phillips SL, Barlow NJ, Bowman CJ, Foster PM. Altered gene expression during rat Wolffian duct development in response to in utero exposure to the antiandrogen linuron. Toxicol Sci. 2003 Jul; 74(1):114-28. PMID: 12730624.
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      33. Bowman CJ, Kroll KJ, Gross TG, Denslow ND. Estradiol-induced gene expression in largemouth bass (Micropterus salmoides). Mol Cell Endocrinol. 2002 Oct 31; 196(1-2):67-77. PMID: 12385826.
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      34. Hemmer MJ, Bowman CJ, Hemmer BL, Friedman SD, Marcovich D, Kroll KJ, Denslow ND. Vitellogenin mRNA regulation and plasma clearance in male sheepshead minnows, (Cyprinodon variegatus) after cessation of exposure to 17 beta-estradiol and p-nonylphenol. Aquat Toxicol. 2002 Jul; 58(1-2):99-112. PMID: 12062157.
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