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    Christopher Waddling, PhD

    TitleSpecialist
    SchoolUCSF School of Medicine
    DepartmentBiochemistry and Biophysics
    Address600 16th St
    San Francisco CA 94158
    Phone415-476-8288
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      Collapse Biography 
      Collapse Awards and Honors
      University of California, San Francisco2011Chancellor's Award for GLBT Leadership
      University of California, San Francisco2014Chancellor's Award for Public Service

      Collapse Overview 
      Collapse Overview
      • Experienced in project management including: work plan development; problem solving; personnel management; and complex coordination of, and consensus building with, internal and external parties
      • Skilled at taking projects from planning to implementation
      • Experienced in resource allocation and management of sizable operating budgets
      • Advocate for funding and resources to maintain the crystallography group's competitive edge
      • Graduate-level educator
      • Authored successful collaborative grant applications that secured core lab equipment and salary funding
      • Facilitate networking between local crystallographers
      • Maintain comprehensive and detailed website for both the MSG and the Crystallography lab, which includes instructional and safety videos, links to the latest software, and information on the latest techniques
      • Rapid response to queries and calls for assistance
      • Experienced crystallographer with skills in screening; optimization; data collection (including SAD and MAD); structure solution and refinement; analysis of structural and functional properties of proteins and the exploration of small molecule inhibitors, ligands and targets of interest
      • Ability to be detail oriented while remaining to see the bigger picture

      Specialties

      Laboratory management; instrument maintenance; grant writing; crystallography (crystallization, optimization, data collection - rotating anode and synchrotron - ultra high-resolution protein structure solution and analysis); software maintenance; project management; budget and purchasing; teaching complex subjects; public speaking; web site design and maintenance; networking.

      PROFESSIONAL EXPERIENCE

      Responsible for day-to-day management of a 150-client, 30-lab supported core facility with an annual operating budget of over $250000; annually teaching two graduate-level courses; grant writing; policy making; software and equipment; contributing to crystallography research efforts at UCSF.

      Highlights:

      · X-ray Facility Management: management and policy initiatives and improvements quadrupled the UCSF Crystallography Facility client base; positively impacted the learning environment and quality of scientific study; increased Facility throughput; directed grant applications for new equipment and salary support; implemented acquisition of state-of-the-art technological advances; managed cooperative agreements with private sector; maintain Crystallography Facility equipment, software, and web site.
      · Teaching and Training: Initiated, developed, and teach the practical section of two graduate-level crystallography courses; developed and filmed an iBioSeminars online lecture course; on-going training of all users of our facility at UCSF and at the Advanced Light Source at the Lawrence Berkeley National Labs.
      - Maintain relationships with equipment and software specialists in crystallography to remain current with the state of the art in our and related fields
      · Research: experienced in protein crystallization, optimization and data collection, refinement, and structure solution; experienced at analyzing the structural and functional properties of proteins and exploring their interactions with ligands, inhibitors, and therapeutic small molecules.
      · Experienced user of the ALS synchrotron beamlines (SAD, MAD) and rotating anode x-ray equipment

      RESEARCH AWARDS AND GRANTS

      08/2008 – 08/2009 QB3 UCSF 08-09 R1 Award, Fund 09515/DPA 555262, PI: David Agard
      Salary support for James Holton (UCSF/ALS) and Chris Waddling (UCSF) $75,000
      04/2006 – 04/2007 NIH Shared Instrument Grant, S10 RR0222322, PI: Robert Fletterick
      Role: Grant coordination, consultant, and equipment staff person $280,353


      Collapse ORNG Applications 
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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Madrona Y, Waddling CA, Ortiz de Montellano PR. Crystal structures of the CO and NOBound DosS GAF-A domain and implications for DosS signaling in Mycobacterium tuberculosis. Arch Biochem Biophys. 2016 Oct 8; 612:1-8. PMID: 27729224.
        View in: PubMed
      2. Frank DJ, Waddling CA, La M, Ortiz de Montellano PR. Cytochrome P450 125A4, the Third Cholesterol C-26 Hydroxylase from Mycobacterium smegmatis. Biochemistry. 2015 Nov 24; 54(46):6909-16. PMID: 26522442; PMCID: PMC4660985 [Available on 11/01/16].
      3. Gable JE, Lee GM, Jaishankar P, Hearn BR, Waddling CA, Renslo AR, Craik CS. Broad-spectrum allosteric inhibition of herpesvirus proteases. Biochemistry. 2014 Jul 22; 53(28):4648-60. PMID: 24977643; PMCID: PMC4108181.
      4. Kraemer JA, Erb ML, Waddling CA, Montabana EA, Zehr EA, Wang H, Nguyen K, Pham DS, Agard DA, Pogliano J. A phage tubulin assembles dynamic filaments by an atypical mechanism to center viral DNA within the host cell. Cell. 2012 Jun 22; 149(7):1488-99. PMID: 22726436; PMCID: PMC3401054.
      5. Christopher A. Waddling Roger Cramer. . Journal of Inclusion Phenomena and Macrocyclic Chemistry. Crystal structures of the dinitrate-bis-(acetylenedicarboxylate) and acetylenedicarboxylate pseudorotaxane complexes of [24-pyrimidinium crown 6]. 2008; (60):1-8.
      6. Van Roey P, Waddling CA, Fox KM, Belfort M, Derbyshire V. Intertwined structure of the DNA-binding domain of intron endonuclease I-TevI with its substrate. EMBO J. 2001 Jul 16; 20(14):3631-7. PMID: 11447104; PMCID: PMC125541.
      7. Almog R, Waddling CA, Maley F, Maley GF, Van Roey P. Crystal structure of a deletion mutant of human thymidylate synthase Delta (7-29) and its ternary complex with Tomudex and dUMP. Protein Sci. 2001 May; 10(5):988-96. PMID: 11316879; PMCID: PMC2374201.
      8. Waddling CA, Plummer TH, Tarentino AL, Van Roey P. Structural basis for the substrate specificity of endo-beta-N-acetylglucosaminidase F(3). Biochemistry. 2000 Jul 11; 39(27):7878-85. PMID: 10891067.
        View in: PubMed
      9. Khalid A. El Sayed Mark Hamann Christopher A. Waddling Craig Jensen Sang Kook Lee John M. Pezzuto Christina Andersson Dunstan . . Journal of Organic Chemistry. Structurally novel bioconversion products of the marine natural product sarcophine effectively inhibit JB6 cell transformation. 1998; 21(63):7449-7455.
      10. Christopher A. Waddling Cy Fujimoto David Smith K. E. Kim Roger Cramer. . Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry. Crystal structures of the nitrate salt of 24-pyrimidinium crown 6 {5,12,19,26,33,40-hexaamino-3,10,17,24,31,38-hexamethyl[1.6](1,5)pyrimidiniophane} and its degradation product in water-methanol mixtures. 1997; 1675-84.
      11. Christopher A. Waddling Yizeng Ni Mong Liang Ian Manners Peter Park Jason Massey . . Macromolecules. Polymers with Sulfur(VI)-Nitrogen-Phosphorus Backbones: Synthesis, Characterization, and Properties of Atactic Poly[(amino)thionylphosphazenes]. 1996; 10(29):3401-8.
      12. Christopher A. Waddling Donal H. Macartney . . Inorganic Chemistry. Kinetic and Spectroscopic Studies on Pentacyano(N-heterocycle)ferrate(II) Rotaxanes of a-Cyclodextrin with Symmetric and Asymmetric Threads. 1994; 33(25):5912-19.
      13. Christopher A. Waddling Keith J Kutchcoskie Sam Suppiah. . Studies in Surface Science and Catalysis. Catalytic elimination of organics over noble metal catalysts deposited on metal structures of low mass. 1992; 187-96.
      14. Christopher A. Waddling Mong Liang Ian A. Manners Daniel Foucher Charles Honeyman. . Phosphorus, Sulfur and Silicon and the Related Elements. Ring-opening polymerization as a route to new inorganic macromolecules. 1992; 113-20.
      15. Christopher A. Waddling Mong Liang Ian A. Manners. . Polymer Preprints. Poly(thionylphosphazenes); a new class of inorganic polymers with skeletal phosphorus, nitrogen, and sulfur(VI) atoms. 1991.
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