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    Claire Brett, MD

    TitleProfessor
    SchoolUCSF School of Medicine
    DepartmentAnesthesia
    Address550 16th Street
    San Francisco CA 94158
    Phone415-476-6461
    vCardDownload vCard

      Collapse Biography 
      Collapse Education and Training
      University of California, San FranciscoResidency School of Medicine

      Collapse ORNG Applications 
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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Hibma JE, Zur AA, Castro RA, Wittwer MB, Keizer RJ, Yee SW, Goswami S, Stocker SL, Zhang X, Huang Y, Brett CM, Savic RM, Giacomini KM. The Effect of Famotidine, a MATE1-Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin. Clin Pharmacokinet. 2016 Jun; 55(6):711-21. PMID: 26597253.
        View in: PubMed
      2. Morrissey KM, Stocker SL, Chen EC, Castro RA, Brett CM, Giacomini KM. The Effect of Nizatidine, a MATE2K Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin in Healthy Volunteers. Clin Pharmacokinet. 2016 Apr; 55(4):495-506. PMID: 26507723.
        View in: PubMed
      3. Goswami S, Yee SW, Stocker S, Mosley JD, Kubo M, Castro R, Mefford JA, Wen C, Liang X, Witte J, Brett C, Maeda S, Simpson MD, Hedderson MM, Davis RL, Roden DM, Giacomini KM, Savic RM. Genetic variants in transcription factors are associated with the pharmacokinetics and pharmacodynamics of metformin. Clin Pharmacol Ther. 2014 Sep; 96(3):370-9. PMID: 24853734; PMCID: PMC4171106.
      4. Yee SW, Nguyen AN, Brown C, Savic RM, Zhang Y, Castro RA, Cropp CD, Choi JH, Singh D, Tahara H, Stocker SL, Huang Y, Brett CM, Giacomini KM. Reduced renal clearance of cefotaxime in asians with a low-frequency polymorphism of OAT3 (SLC22A8). J Pharm Sci. 2013 Sep; 102(9):3451-7. PMID: 23649425; PMCID: PMC4151246.
      5. Stocker SL, Morrissey KM, Yee SW, Castro RA, Xu L, Dahlin A, Ramirez AH, Roden DM, Wilke RA, McCarty CA, Davis RL, Brett CM, Giacomini KM. The effect of novel promoter variants in MATE1 and MATE2 on the pharmacokinetics and pharmacodynamics of metformin. Clin Pharmacol Ther. 2013 Feb; 93(2):186-94. PMID: 23267855; PMCID: PMC3671611.
      6. Chen Y, Li S, Brown C, Cheatham S, Castro RA, Leabman MK, Urban TJ, Chen L, Yee SW, Choi JH, Huang Y, Brett CM, Burchard EG, Giacomini KM. Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin. Pharmacogenet Genomics. 2009 Jul; 19(7):497-504. PMID: 19483665; PMCID: PMC3104496.
      7. Shu Y, Brown C, Castro RA, Shi RJ, Lin ET, Owen RP, Sheardown SA, Yue L, Burchard EG, Brett CM, Giacomini KM. Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics. Clin Pharmacol Ther. 2008 Feb; 83(2):273-80. PMID: 17609683; PMCID: PMC2976713.
      8. Urban TJ, Brown C, Castro RA, Shah N, Mercer R, Huang Y, Brett CM, Burchard EG, Giacomini KM. Effects of genetic variation in the novel organic cation transporter, OCTN1, on the renal clearance of gabapentin. Clin Pharmacol Ther. 2008 Mar; 83(3):416-21. PMID: 17609685.
        View in: PubMed
      9. Shu Y, Sheardown SA, Brown C, Owen RP, Zhang S, Castro RA, Ianculescu AG, Yue L, Lo JC, Burchard EG, Brett CM, Giacomini KM. Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action. J Clin Invest. 2007 May; 117(5):1422-31. PMID: 17476361; PMCID: PMC1857259.
      10. Giacomini KM, Brett CM, Altman RB, Benowitz NL, Dolan ME, Flockhart DA, Johnson JA, Hayes DF, Klein T, Krauss RM, Kroetz DL, McLeod HL, Nguyen AT, Ratain MJ, Relling MV, Reus V, Roden DM, Schaefer CA, Shuldiner AR, Skaar T, Tantisira K, Tyndale RF, Wang L, Weinshilboum RM, Weiss ST, Zineh I. The pharmacogenetics research network: from SNP discovery to clinical drug response. Clin Pharmacol Ther. 2007 Mar; 81(3):328-45. PMID: 17339863.
        View in: PubMed
      11. Urban TJ, Gallagher RC, Brown C, Castro RA, Lagpacan LL, Brett CM, Taylor TR, Carlson EJ, Ferrin TE, Burchard EG, Packman S, Giacomini KM. Functional genetic diversity in the high-affinity carnitine transporter OCTN2 (SLC22A5). Mol Pharmacol. 2006 Nov; 70(5):1602-11. PMID: 16931768.
        View in: PubMed
      12. Badagnani I, Castro RA, Taylor TR, Brett CM, Huang CC, Stryke D, Kawamoto M, Johns SJ, Ferrin TE, Carlson EJ, Burchard EG, Giacomini KM. Interaction of methotrexate with organic-anion transporting polypeptide 1A2 and its genetic variants. J Pharmacol Exp Ther. 2006 Aug; 318(2):521-9. PMID: 16702441.
        View in: PubMed
      13. Shu Y, Urban TJ, Leabman MK, Fujita T, Erdman AR, Lagpacan LL, Brown C, Castro RA, Huang CC, Stryke D, Kawamoto M, Johns SJ, Taylor TR, Chan W, De La Cruz M, Carlson EJ, Ferrin TE, Brett CM, Burchard EG, Herskowitz I, Kroetz DL, Giacomini KM. PharmGKB submission update: V. PMT submissions of genetic variation in SLC22 family transporters. Pharmacol Rev. 2006 Mar; 58(1):3-4. PMID: 16507878.
        View in: PubMed
      14. Erdman AR, Mangravite LM, Urban TJ, Lagpacan LL, Castro RA, de la Cruz M, Chan W, Huang CC, Johns SJ, Kawamoto M, Stryke D, Taylor TR, Carlson EJ, Ferrin TE, Brett CM, Burchard EG, Giacomini KM. The human organic anion transporter 3 (OAT3; SLC22A8): genetic variation and functional genomics. Am J Physiol Renal Physiol. 2006 Apr; 290(4):F905-12. PMID: 16291576.
        View in: PubMed
      15. Fujita T, Brown C, Carlson EJ, Taylor T, de la Cruz M, Johns SJ, Stryke D, Kawamoto M, Fujita K, Castro R, Chen CW, Lin ET, Brett CM, Burchard EG, Ferrin TE, Huang CC, Leabman MK, Giacomini KM. Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1). Pharmacogenet Genomics. 2005 Apr; 15(4):201-9. PMID: 15864112.
        View in: PubMed
      16. Badagnani I, Chan W, Castro RA, Brett CM, Huang CC, Stryke D, Kawamoto M, Johns SJ, Ferrin TE, Carlson EJ, Burchard EG, Giacomini KM. Functional analysis of genetic variants in the human concentrative nucleoside transporter 3 (CNT3; SLC28A3). Pharmacogenomics J. 2005; 5(3):157-65. PMID: 15738947.
        View in: PubMed
      17. Pauli-Magnus C, Feiner J, Brett C, Lin E, Kroetz DL. No effect of MDR1 C3435T variant on loperamide disposition and central nervous system effects. Clin Pharmacol Ther. 2003 Nov; 74(5):487-98. PMID: 14586389.
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      18. Weihe E, Schäfer MK, Schütz B, Anlauf M, Depboylu C, Brett C, Chen L, Eiden LE. From the cholinergic gene locus to the cholinergic neuron. J Physiol Paris. 1998 Oct-Dec; 92(5-6):385-8. PMID: 9789842.
        View in: PubMed
      19. Bauman GS, Brett CM, Ciricillo SF, Larson DA, Sneed P, Staplers LJ, Edwards M, Wara WM. Anesthesia for pediatric stereotactic radiosurgery. Anesthesiology. 1998 Jul; 89(1):255-7. PMID: 9667316.
        View in: PubMed
      20. Washington CB, Giacomini KM, Brett CM. Nucleoside transport in isolated human and rhesus choroid plexus tissue slices. Pharm Res. 1998 Jul; 15(7):1145-7. PMID: 9688074.
        View in: PubMed
      21. Zhang L, Brett CM, Giacomini KM. Role of organic cation transporters in drug absorption and elimination. Annu Rev Pharmacol Toxicol. 1998; 38:431-60. PMID: 9597162.
        View in: PubMed
      22. Ramanathan VK, Brett CM, Giacomini KM. Na+-dependent gamma-aminobutyric acid (GABA) transport in the choroid plexus of rabbit. Biochim Biophys Acta. 1997 Nov 13; 1330(1):94-102. PMID: 9375816.
        View in: PubMed
      23. Ramanathan VK, Chung SJ, Giacomini KM, Brett CM. Taurine transport in cultured choroid plexus. Pharm Res. 1997 Apr; 14(4):406-9. PMID: 9144722.
        View in: PubMed
      24. Ramanathan VK, Hui AC, Brett CM, Giacomini KM. Primary cell culture of the rabbit choroid plexus: an experimental system to investigate membrane transport. Pharm Res. 1996 Jun; 13(6):952-6. PMID: 8792439.
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      25. Chung SJ, Ramanathan VK, Brett CM, Giacomini KM. Saturable disposition of taurine in the rat cerebrospinal fluid. J Pharmacol Exp Ther. 1996 Feb; 276(2):676-82. PMID: 8632336.
        View in: PubMed
      26. Washington CB, Giacomini KM, Brett CM. Methods of study drug transport in isolated choroid plexus tissue and cultured cells. Pharm Biotechnol. 1996; 8:259-83. PMID: 8791814.
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      27. Gutierrez MM, Brett CM, Giacomini KM. Isolated renal brush border and basolateral membrane vesicles and cultured renal cells. Pharm Biotechnol. 1996; 8:193-210. PMID: 8791811.
        View in: PubMed
      28. Washington CB, Brett CM, Wu X, Giacomini KM. The effect of N-ethylmaleimide on the Na(+)-dependent nucleoside transporter (N3) in rabbit choroid plexus. J Pharmacol Exp Ther. 1995 Jul; 274(1):110-4. PMID: 7616386.
        View in: PubMed
      29. Chung SJ, Ramanathan V, Giacomini KM, Brett CM. Characterization of a sodium-dependent taurine transporter in rabbit choroid plexus. Biochim Biophys Acta. 1994 Jul 13; 1193(1):10-6. PMID: 8038178.
        View in: PubMed
      30. Cashman JR, Park SB, Yang ZC, Washington CB, Gomez DY, Giacomini KM, Brett CM. Chemical, enzymatic, and human enantioselective S-oxygenation of cimetidine. Drug Metab Dispos. 1993 Jul-Aug; 21(4):587-97. PMID: 8104117.
        View in: PubMed
      31. Brett CM, Washington CB, Ott RJ, Gutierrez MM, Giacomini KM. Interaction of nucleoside analogues with the sodium-nucleoside transport system in brush border membrane vesicles from human kidney. Pharm Res. 1993 Mar; 10(3):423-6. PMID: 8464817.
        View in: PubMed
      32. Wu X, Yuan G, Brett CM, Hui AC, Giacomini KM. Sodium-dependent nucleoside transport in choroid plexus from rabbit. Evidence for a single transporter for purine and pyrimidine nucleosides. J Biol Chem. 1992 May 5; 267(13):8813-8. PMID: 1315741.
        View in: PubMed
      33. Gutierrez MM, Brett CM, Ott RJ, Hui AC, Giacomini KM. Nucleoside transport in brush border membrane vesicles from human kidney. Biochim Biophys Acta. 1992 Mar 23; 1105(1):1-9. PMID: 1567888.
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      34. Brett CM, Teitel DF, Heymann MA, Rudolph AM. The young lamb can increase cardiovascular performance during isoflurane anesthesia. Anesthesiology. 1989 Nov; 71(5):751-6. PMID: 2817470.
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      35. Henderson JM, Brodsky DA, Fisher DM, Brett CM, Hertzka RE. Pre-induction of anesthesia in pediatric patients with nasally administered sufentanil. Anesthesiology. 1988 May; 68(5):671-5. PMID: 2897172.
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      36. Shaddy RE, Teitel DF, Brett C. Short-term hemodynamic effects of captopril in infants with congestive heart failure. Am J Dis Child. 1988 Jan; 142(1):100-5. PMID: 3277384.
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      37. Brett CM, Fisher DM. Thiopental dose-response relations in unpremedicated infants, children, and adults. Anesth Analg. 1987 Oct; 66(10):1024-7. PMID: 3631563.
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      38. Brett CM, Teitel DF, Heymann MA, Rudolph AM. The cardiovascular effects of isoflurane in lambs. Anesthesiology. 1987 Jul; 67(1):60-5. PMID: 3605737.
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      39. Brett CM, Wara WM, Hamilton WK. Anesthesia for infants during radiotherapy: an insufflation technique. Anesthesiology. 1986 Mar; 64(3):402-5. PMID: 3954139.
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      40. Fisher DM, Robinson S, Brett CM, Perin G, Gregory GA. Comparison of enflurane, halothane, and isoflurane for diagnostic and therapeutic procedures in children with malignancies. Anesthesiology. 1985 Dec; 63(6):647-50. PMID: 3840660.
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      41. Teitel DF, Sidi D, Chin T, Brett C, Heymann MA, Rudolph AM. Developmental changes in myocardial contractile reserve in the lamb. Pediatr Res. 1985 Sep; 19(9):948-55. PMID: 4047765.
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      42. Mahony L, Heymann MA, Carnero V, Brett C, Clyman RI. When to treat the patent ductus arteriosus with indomethacin in very-low-birth-weight infants. Adv Prostaglandin Thromboxane Leukot Res. 1983; 12:491-4. PMID: 6221636.
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      43. Mahony L, Carnero V, Brett C, Heymann MA, Clyman RI. Prophylactic indomethacin therapy for patent ductus arteriosus in very-low-birth-weight infants. N Engl J Med. 1982 Mar 4; 306(9):506-10. PMID: 7035955.
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