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Claudia Petritsch, PhD

TitleAssociate Professor
SchoolUCSF School of Medicine
DepartmentNeurological Surgery
Address1450 3rd Street
San Francisco CA 94158
Phone415-476-1636
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPostdoctoral StudiesGraduate Division

    Collapse Overview 
    Collapse Overview
    Stem and progenitor cells can switch between asymmetric and symmetric cell division modes presumably to respond to micro-environment changes such as those induced by tissue injury and cancer. The Petritsch lab elucidates the regulation of cell division mode of oligodendrocyte progenitor cells (OPCs). We use OPCs as a model system to understand the impact of changes in cell division mode, both by intrinsic and extrinsic factors and in the context of the healthy and diseased brain. Our findings show that aberrant control of cell division mode carries the risk of cancer initiation and progression. In a collaborative effort, we translate our basic insights into stem and progenitor biology into improved treatment of brain tumor patients.


    Education, Training, and Previous Positions

    1996: Ph.D.: Institute for Molecular Pathology (IMP) Vienna, Austria

    1997-2002: Postdoctoral Fellow, Howard Hughes Medical Institute, University of California, San Francisco

    2002-2003: Postdoctoral Researcher, Department of Physiology, University of California, San Francisco

    2003-2005: Group Leader, Gene Center and Department of Biochemistry, Ludwig-Maximilian-University, Munich, Germany

    2005-2008: Associate Research Biochemist, Department of Neurological Surgery, University of California, San Francisco

    2008-2015: Assistant Professor, Department of Neurological Surgery, University of California, San Francisco

    2015-present: Associate Professor, Department of Neurological Surgery, University of California, San Francisco


    Collapse Research 
    Collapse Research Activities and Funding
    Investigating ASPM regulation of asymmetric division for therapeutic opportunities
    NIH/NINDS R21NS099836Sep 30, 2016 - Aug 31, 2018
    Role: Principal Investigator
    BRAF Mutation in Malignant Astrocytoma Origin, Evolution, and Response to Therapy
    NIH/NINDS R01NS080619Sep 1, 2012 - Aug 31, 2017
    Role: Co-Principal Investigator
    A causal role for asymmetric cell division defects in glioma initiation
    NIH/NCI R01CA164746Dec 13, 2011 - Nov 30, 2016
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News
    Collapse Global Health

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Daynac M, Petritsch CK. Regulation of Asymmetric Cell Division in Mammalian Neural Stem and Cancer Precursor Cells. Results Probl Cell Differ. 2017; 61:375-399. PMID: 28409314.
      View in: PubMed
    2. Grossauer S, Koeck K, Murphy NE, Meyers ID, Daynac M, Truffaux N, Truong AY, Nicolaides TP, McMahon M, Berger MS, Phillips JJ, James CD, Petritsch CK. Concurrent MEK targeted therapy prevents MAPK pathway reactivation during BRAFV600E targeted inhibition in a novel syngeneic murine glioma model. Oncotarget. 2016 Nov 15; 7(46):75839-75853. PMID: 27713119.
      View in: PubMed
    3. Olow A, Mueller S, Yang X, Hashizume R, Meyerowitz J, Weiss WA, Resnick AC, Waanders AJ, Stalpers LJ, Berger MS, Gupta N, James CD, Petritsch C, Haas-Kogan DA, et al. BRAF Status in Personalizing Treatment Approaches for Pediatric Gliomas. Clin Cancer Res. 2016 Nov 01; 22(21):5312-5321. PMID: 27217440.
      View in: PubMed
    4. Andor N, Graham TA, Jansen M, Xia LC, Aktipis CA, Petritsch C, Ji HP, Maley CC. Pan-cancer analysis of the extent and consequences of intratumor heterogeneity. Nat Med. 2016 Jan; 22(1):105-13. PMID: 26618723; PMCID: PMC4830693.
    5. Lerner RG, Grossauer S, Kadkhodaei B, Meyers I, Sidorov M, Koeck K, Hashizume R, Ozawa T, Phillips JJ, Berger MS, Nicolaides T, James CD, Petritsch CK. Targeting a Plk1-Controlled Polarity Checkpoint in Therapy-Resistant Glioblastoma-Propagating Cells. Cancer Res. 2015 Dec 15; 75(24):5355-66. PMID: 26573800; PMCID: PMC4698003 [Available on 12/15/16].
    6. Bakhoum SF, Kabeche L, Wood MD, Laucius CD, Qu D, Laughney AM, Reynolds GE, Louie RJ, Phillips J, Chan DA, Zaki BI, Murnane JP, Petritsch C, Compton DA. Numerical chromosomal instability mediates susceptibility to radiation treatment. Nat Commun. 2015 Jan 21; 6:5990. PMID: 25606712; PMCID: PMC4516720.
    7. Hashizume R, Andor N, Ihara Y, Lerner R, Gan H, Chen X, Fang D, Huang X, Tom MW, Ngo V, Solomon D, Mueller S, Paris PL, Zhang Z, Petritsch C, Gupta N, Waldman TA, James CD. Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma. Nat Med. 2014 Dec; 20(12):1394-6. PMID: 25401693; PMCID: PMC4257862.
    8. Berberoglu MA, Dong Z, Li G, Zheng J, Trejo Martinez Ldel C, Peng J, Wagle M, Reichholf B, Petritsch C, Li H, Pleasure SJ, Guo S. Heterogeneously expressed fezf2 patterns gradient Notch activity in balancing the quiescence, proliferation, and differentiation of adult neural stem cells. J Neurosci. 2014 Oct 15; 34(42):13911-23. PMID: 25319688; PMCID: PMC4198537.
    9. Lerner RG, Petritsch C. A microRNA-operated switch of asymmetric-to-symmetric cancer stem cell divisions. Nat Cell Biol. 2014 Mar; 16(3):212-4. PMID: 24576899.
      View in: PubMed
    10. Lewis KM, Petritsch C. ASYMMETRIC CELL DIVISION: IMPLICATIONS FOR GLIOMA DEVELOPMENT AND TREATMENT. Transl Neurosci. 2013 Dec; 4(4):484-503. PMID: 25530875.
      View in: PubMed
    11. Andor N, Harness JV, Müller S, Mewes HW, Petritsch C. EXPANDS: expanding ploidy and allele frequency on nested subpopulations. Bioinformatics. 2014 Jan 01; 30(1):50-60. PMID: 24177718; PMCID: PMC3866558.
    12. Gómez-López S, Lerner RG, Petritsch C. Asymmetric cell division of stem and progenitor cells during homeostasis and cancer. Cell Mol Life Sci. 2014 Feb; 71(4):575-97. PMID: 23771628; PMCID: PMC3901929.
    13. Wade A, Robinson AE, Engler JR, Petritsch C, James CD, Phillips JJ. Proteoglycans and their roles in brain cancer. FEBS J. 2013 May; 280(10):2399-417. PMID: 23281850; PMCID: PMC3644380.
    14. Huillard E, Hashizume R, Phillips JJ, Griveau A, Ihrie RA, Aoki Y, Nicolaides T, Perry A, Waldman T, McMahon M, Weiss WA, Petritsch C, James CD, Rowitch DH. Cooperative interactions of BRAFV600E kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy. Proc Natl Acad Sci U S A. 2012 May 29; 109(22):8710-5. PMID: 22586120; PMCID: PMC3365162.
    15. Sugiarto S, Persson AI, Munoz EG, Waldhuber M, Lamagna C, Andor N, Hanecker P, Ayers-Ringler J, Phillips J, Siu J, Lim DA, Vandenberg S, Stallcup W, Berger MS, Bergers G, Weiss WA, Petritsch C. Asymmetry-defective oligodendrocyte progenitors are glioma precursors. Cancer Cell. 2011 Sep 13; 20(3):328-40. PMID: 21907924; PMCID: PMC3297490.
    16. Ouyang Y, Petritsch C, Wen H, Jan L, Jan YN, Lu B. Dronc caspase exerts a non-apoptotic function to restrain phospho-Numb-induced ectopic neuroblast formation in Drosophila. Development. 2011 Jun; 138(11):2185-96. PMID: 21558368; PMCID: PMC3091490.
    17. Persson AI, Petritsch C, Swartling FJ, Itsara M, Sim FJ, Auvergne R, Goldenberg DD, Vandenberg SR, Nguyen KN, Yakovenko S, Ayers-Ringler J, Nishiyama A, Stallcup WB, Berger MS, Bergers G, McKnight TR, Goldman SA, Weiss WA. Non-stem cell origin for oligodendroglioma. Cancer Cell. 2010 Dec 14; 18(6):669-82. PMID: 21156288; PMCID: PMC3031116.
    18. Silber J, Lim DA, Petritsch C, Persson AI, Maunakea AK, Yu M, Vandenberg SR, Ginzinger DG, James CD, Costello JF, Bergers G, Weiss WA, Alvarez-Buylla A, Hodgson JG. miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells. BMC Med. 2008 Jun 24; 6:14. PMID: 18577219; PMCID: PMC2443372.
    19. Erben V, Waldhuber M, Langer D, Fetka I, Jansen RP, Petritsch C. Asymmetric localization of the adaptor protein Miranda in neuroblasts is achieved by diffusion and sequential interaction of Myosin II and VI. J Cell Sci. 2008 May 01; 121(Pt 9):1403-14. PMID: 18398000.
      View in: PubMed
    20. Du R, Petritsch C, Lu K, Liu P, Haller A, Ganss R, Song H, Vandenberg S, Bergers G. Matrix metalloproteinase-2 regulates vascular patterning and growth affecting tumor cell survival and invasion in GBM. Neuro Oncol. 2008 Jun; 10(3):254-64. PMID: 18359864; PMCID: PMC2563048.
    21. Du R, Lu KV, Petritsch C, Liu P, Ganss R, Passegué E, Song H, Vandenberg S, Johnson RS, Werb Z, Bergers G. HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell. 2008 Mar; 13(3):206-20. PMID: 18328425; PMCID: PMC2643426.
    22. Waldhuber M, Emoto K, Petritsch C. The Drosophila caspase DRONC is required for metamorphosis and cell death in response to irradiation and developmental signals. Mech Dev. 2005 Jul; 122(7-8):914-27. PMID: 15922568.
      View in: PubMed
    23. Ye B, Petritsch C, Clark IE, Gavis ER, Jan LY, Jan YN. Nanos and Pumilio are essential for dendrite morphogenesis in Drosophila peripheral neurons. Curr Biol. 2004 Feb 17; 14(4):314-21. PMID: 14972682.
      View in: PubMed
    24. Petritsch C, Tavosanis G, Turck CW, Jan LY, Jan YN. The Drosophila myosin VI Jaguar is required for basal protein targeting and correct spindle orientation in mitotic neuroblasts. Dev Cell. 2003 Feb; 4(2):273-81. PMID: 12586070.
      View in: PubMed
    25. Petritsch C, Beug H, Balmain A, Oft M. TGF-beta inhibits p70 S6 kinase via protein phosphatase 2A to induce G(1) arrest. Genes Dev. 2000 Dec 15; 14(24):3093-101. PMID: 11124802; PMCID: PMC317138.
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