Claudia Petritsch, PhD
|School||UCSF School of Medicine|
|Address||1450 3rd Street|
San Francisco CA 94158
Dr. Petritsch’s objective is to elucidate defects in cell division and differentiation of brain cancer stem cells and to distinguish them from normal adult neural stem and progenitor cells. The Petritsch lab utilizes transgenic model organisms and novel cell culture assays to investigate in particular whether defects in asymmetric division of stem and progenitor cells in response to oncogenic mutations are responsible for their neoplastic transformation and the emergence of brain cancer stem cells.
Dr. Petritsch has previously identified novel regulators of asymmetric cell division essential for proper neurogenesis and stem cell self-renewal. The Petritsch lab has recently discovered that normal adult neural stem cells undergo asymmetric cell divisions to generate glial cells and that this process is disrupted in response to oncogenic mutations in premalignant and glioma stem cells.
Currently, the Petritsch lab is studying regulators of asymmetric stem cell division as potential tumor suppressors and oncogenes by utilizing knock out mice and orthotopic transplantation models. Therapy-resistant brain cancer stem cells are the likely origin of many primary and recurrent brain tumors, thus making them an important novel target for brain tumor therapies. We would like to translate these studies into improved diagnostics and therapies for brain cancer patients by identifying novel and specific molecular targets in glioma stem cells.
Education, Training, and Previous Positions
1990: MSc, University of Vienna BioCenter, Vienna, Austria
1996: PhD, University of Vienna BioCenter, Vienna, Austria
1997-2002: Postdoctoral Fellow, Howard Hughes Medical Institute, University of California, San Francisco
2002-2003: Postdoctoral Researcher, Department of Physiology, University of California, San Francisco
2003-2005: Lecturer, Gene Center and Department of Biochemistry, Ludwig-Maximilian-University, Munich, Germany
2005-2008: Associate Research Biochemist, Department of Neurological Surgery, University of California, San Francisco
2008-Present: Assistant Adjunct Professor, Department of Neurological Surgery, University of California, San Francisco
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