 Claudia Petritsch, PhD
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| Title | Assistant Professor |
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| School | UCSF School of Medicine |
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| Department | Neurological Surgery |
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| Address | 1450 3rd Street
San Francisco CA 94158
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| Phone | 415-800-3686 |
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 Overview Dr. Petritsch’s objective is to elucidate defects in cell division and differentiation of brain cancer stem cells and to distinguish them from normal adult neural stem and progenitor cells. The Petritsch lab utilizes transgenic model organisms and novel cell culture assays to investigate in particular whether defects in asymmetric division of stem and progenitor cells in response to oncogenic mutations are responsible for their neoplastic transformation and the emergence of brain cancer stem cells.
Dr. Petritsch has previously identified novel regulators of asymmetric cell division essential for proper neurogenesis and stem cell self-renewal. The Petritsch lab has recently discovered that normal adult neural stem cells undergo asymmetric cell divisions to generate glial cells and that this process is disrupted in response to oncogenic mutations in premalignant and glioma stem cells.
Currently, the Petritsch lab is studying regulators of asymmetric stem cell division as potential tumor suppressors and oncogenes by utilizing knock out mice and orthotopic transplantation models. Therapy-resistant brain cancer stem cells are the likely origin of many primary and recurrent brain tumors, thus making them an important novel target for brain tumor therapies. We would like to translate these studies into improved diagnostics and therapies for brain cancer patients by identifying novel and specific molecular targets in glioma stem cells.
Education, Training, and Previous Positions
1990: MSc, University of Vienna BioCenter, Vienna, Austria
1996: PhD, University of Vienna BioCenter, Vienna, Austria
1997-2002: Postdoctoral Fellow, Howard Hughes Medical Institute, University of California, San Francisco
2002-2003: Postdoctoral Researcher, Department of Physiology, University of California, San Francisco
2003-2005: Lecturer, Gene Center and Department of Biochemistry, Ludwig-Maximilian-University, Munich, Germany
2005-2008: Associate Research Biochemist, Department of Neurological Surgery, University of California, San Francisco
2008-Present: Assistant Adjunct Professor, Department of Neurological Surgery, University of California, San Francisco
Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
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Wade A, Robinson AE, Engler JR, Petritsch C, James CD, Phillips JJ. Proteoglycans and their roles in brain cancer. FEBS J. 2013 May; 280(10):2399-417.
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Huillard E, Hashizume R, Phillips JJ, Griveau A, Ihrie RA, Aoki Y, Nicolaides T, Perry A, Waldman T, McMahon M, Weiss WA, Petritsch C, James CD, Rowitch DH. Cooperative interactions of BRAFV600E kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy. Proc Natl Acad Sci U S A. 2012 May 29; 109(22):8710-5.
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Sugiarto S, Persson AI, Munoz EG, Waldhuber M, Lamagna C, Andor N, Hanecker P, Ayers-Ringler J, Phillips J, Siu J, Lim DA, Vandenberg S, Stallcup W, Berger MS, Bergers G, Weiss WA, Petritsch C. Asymmetry-defective oligodendrocyte progenitors are glioma precursors. Cancer Cell. 2011 Sep 13; 20(3):328-40.
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Ouyang Y, Petritsch C, Wen H, Jan L, Jan YN, Lu B. Dronc caspase exerts a non-apoptotic function to restrain phospho-Numb-induced ectopic neuroblast formation in Drosophila. Development. 2011 Jun; 138(11):2185-96.
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Persson AI, Petritsch C, Swartling FJ, Itsara M, Sim FJ, Auvergne R, Goldenberg DD, Vandenberg SR, Nguyen KN, Yakovenko S, Ayers-Ringler J, Nishiyama A, Stallcup WB, Berger MS, Bergers G, McKnight TR, Goldman SA, Weiss WA. Non-stem cell origin for oligodendroglioma. Cancer Cell. 2010 Dec 14; 18(6):669-82.
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Silber J, Lim DA, Petritsch C, Persson AI, Maunakea AK, Yu M, Vandenberg SR, Ginzinger DG, James CD, Costello JF, Bergers G, Weiss WA, Alvarez-Buylla A, Hodgson JG. miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells. BMC Med. 2008; 6:14.
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Erben V, Waldhuber M, Langer D, Fetka I, Jansen RP, Petritsch C. Asymmetric localization of the adaptor protein Miranda in neuroblasts is achieved by diffusion and sequential interaction of Myosin II and VI. J Cell Sci. 2008 May 1; 121(Pt 9):1403-14.
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Du R, Petritsch C, Lu K, Liu P, Haller A, Ganss R, Song H, Vandenberg S, Bergers G. Matrix metalloproteinase-2 regulates vascular patterning and growth affecting tumor cell survival and invasion in GBM. Neuro Oncol. 2008 Jun; 10(3):254-64.
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Du R, Lu KV, Petritsch C, Liu P, Ganss R, Passegué E, Song H, Vandenberg S, Johnson RS, Werb Z, Bergers G. HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell. 2008 Mar; 13(3):206-20.
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Waldhuber M, Emoto K, Petritsch C. The Drosophila caspase DRONC is required for metamorphosis and cell death in response to irradiation and developmental signals. Mech Dev. 2005 Jul; 122(7-8):914-27.
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Ye B, Petritsch C, Clark IE, Gavis ER, Jan LY, Jan YN. Nanos and Pumilio are essential for dendrite morphogenesis in Drosophila peripheral neurons. Curr Biol. 2004 Feb 17; 14(4):314-21.
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Petritsch C, Tavosanis G, Turck CW, Jan LY, Jan YN. The Drosophila myosin VI Jaguar is required for basal protein targeting and correct spindle orientation in mitotic neuroblasts. Dev Cell. 2003 Feb; 4(2):273-81.
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Petritsch C, Beug H, Balmain A, Oft M. TGF-beta inhibits p70 S6 kinase via protein phosphatase 2A to induce G(1) arrest. Genes Dev. 2000 Dec 15; 14(24):3093-101.
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Edelmann HM, Kühne C, Petritsch C, Ballou LM. Cell cycle regulation of p70 S6 kinase and p42/p44 mitogen-activated protein kinases in Swiss mouse 3T3 fibroblasts. J Biol Chem. 1996 Jan 12; 271(2):963-71.
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Petritsch C, Woscholski R, Edelmann HM, Ballou LM. Activation of p70 S6 kinase and erk-encoded mitogen-activated protein kinases is resistant to high cyclic nucleotide levels in Swiss 3T3 fibroblasts. J Biol Chem. 1995 Nov 3; 270(44):26619-25.
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Petritsch C, Woscholski R, Edelmann HM, Parker PJ, Ballou LM. Selective inhibition of p70 S6 kinase activation by phosphatidylinositol 3-kinase inhibitors. Eur J Biochem. 1995 Jun 1; 230(2):431-8.
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