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    Claudia Petritsch, PhD

    TitleAssociate Professor
    SchoolUCSF School of Medicine
    DepartmentNeurological Surgery
    Address1450 3rd Street
    San Francisco CA 94158
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      University of California, San FranciscoPostdoctoral StudiesGraduate Division

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      Stem and progenitor cells can switch between asymmetric and symmetric cell division modes presumably to respond to micro-environment changes such as those induced by tissue injury and cancer. The Petritsch lab elucidates the regulation of cell division mode of oligodendrocyte progenitor cells (OPCs). We use OPCs as a model system to understand the impact of changes in cell division mode, both by intrinsic and extrinsic factors and in the context of the healthy and diseased brain. Our findings show that aberrant control of cell division mode carries the risk of cancer initiation and progression. In a collaborative effort, we translate our basic insights into stem and progenitor biology into improved treatment of brain tumor patients.

      Education, Training, and Previous Positions

      1996: Ph.D.: Institute for Molecular Pathology (IMP) Vienna, Austria

      1997-2002: Postdoctoral Fellow, Howard Hughes Medical Institute, University of California, San Francisco

      2002-2003: Postdoctoral Researcher, Department of Physiology, University of California, San Francisco

      2003-2005: Group Leader, Gene Center and Department of Biochemistry, Ludwig-Maximilian-University, Munich, Germany

      2005-2008: Associate Research Biochemist, Department of Neurological Surgery, University of California, San Francisco

      2008-2015: Assistant Professor, Department of Neurological Surgery, University of California, San Francisco

      2015-present: Associate Professor, Department of Neurological Surgery, University of California, San Francisco

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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Andor N, Graham TA, Jansen M, Xia LC, Aktipis CA, Petritsch C, Ji HP, Maley CC. Pan-cancer analysis of the extent and consequences of intratumor heterogeneity. Nat Med. 2016 Jan; 22(1):105-13. PMID: 26618723.
        View in: PubMed
      2. Lerner RG, Grossauer S, Kadkhodaei B, Meyers I, Sidorov M, Koeck K, Hashizume R, Ozawa T, Phillips JJ, Berger MS, Nicolaides T, James CD, Petritsch CK. Targeting a Plk1-Controlled Polarity Checkpoint in Therapy-Resistant Glioblastoma-Propagating Cells. Cancer Res. 2015 Dec 15; 75(24):5355-66. PMID: 26573800.
        View in: PubMed
      3. Bakhoum SF, Kabeche L, Wood MD, Laucius CD, Qu D, Laughney AM, Reynolds GE, Louie RJ, Phillips J, Chan DA, Zaki BI, Murnane JP, Petritsch C, Compton DA. Numerical chromosomal instability mediates susceptibility to radiation treatment. Nat Commun. 2015; 6:5990. PMID: 25606712; PMCID: PMC4516720.
      4. Hashizume R, Andor N, Ihara Y, Lerner R, Gan H, Chen X, Fang D, Huang X, Tom MW, Ngo V, Solomon D, Mueller S, Paris PL, Zhang Z, Petritsch C, Gupta N, Waldman TA, James CD. Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma. Nat Med. 2014 Dec; 20(12):1394-6. PMID: 25401693; PMCID: PMC4257862.
      5. Berberoglu MA, Dong Z, Li G, Zheng J, Trejo Martinez Ldel C, Peng J, Wagle M, Reichholf B, Petritsch C, Li H, Pleasure SJ, Guo S. Heterogeneously expressed fezf2 patterns gradient Notch activity in balancing the quiescence, proliferation, and differentiation of adult neural stem cells. J Neurosci. 2014 Oct 15; 34(42):13911-23. PMID: 25319688; PMCID: PMC4198537.
      6. Lerner RG, Petritsch C. A microRNA-operated switch of asymmetric-to-symmetric cancer stem cell divisions. Nat Cell Biol. 2014 Mar; 16(3):212-4. PMID: 24576899.
        View in: PubMed
      7. Andor N, Harness JV, Müller S, Mewes HW, Petritsch C. EXPANDS: expanding ploidy and allele frequency on nested subpopulations. Bioinformatics. 2014 Jan 1; 30(1):50-60. PMID: 24177718; PMCID: PMC3866558.
      8. Gómez-López S, Lerner RG, Petritsch C. Asymmetric cell division of stem and progenitor cells during homeostasis and cancer. Cell Mol Life Sci. 2014 Feb; 71(4):575-97. PMID: 23771628; PMCID: PMC3901929.
      9. Wade A, Robinson AE, Engler JR, Petritsch C, James CD, Phillips JJ. Proteoglycans and their roles in brain cancer. FEBS J. 2013 May; 280(10):2399-417. PMID: 23281850; PMCID: PMC3644380.
      10. Huillard E, Hashizume R, Phillips JJ, Griveau A, Ihrie RA, Aoki Y, Nicolaides T, Perry A, Waldman T, McMahon M, Weiss WA, Petritsch C, James CD, Rowitch DH. Cooperative interactions of BRAFV600E kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy. Proc Natl Acad Sci U S A. 2012 May 29; 109(22):8710-5. PMID: 22586120; PMCID: PMC3365162.
      11. Sugiarto S, Persson AI, Munoz EG, Waldhuber M, Lamagna C, Andor N, Hanecker P, Ayers-Ringler J, Phillips J, Siu J, Lim DA, Vandenberg S, Stallcup W, Berger MS, Bergers G, Weiss WA, Petritsch C. Asymmetry-defective oligodendrocyte progenitors are glioma precursors. Cancer Cell. 2011 Sep 13; 20(3):328-40. PMID: 21907924; PMCID: PMC3297490.
      12. Ouyang Y, Petritsch C, Wen H, Jan L, Jan YN, Lu B. Dronc caspase exerts a non-apoptotic function to restrain phospho-Numb-induced ectopic neuroblast formation in Drosophila. Development. 2011 Jun; 138(11):2185-96. PMID: 21558368; PMCID: PMC3091490.
      13. Persson AI, Petritsch C, Swartling FJ, Itsara M, Sim FJ, Auvergne R, Goldenberg DD, Vandenberg SR, Nguyen KN, Yakovenko S, Ayers-Ringler J, Nishiyama A, Stallcup WB, Berger MS, Bergers G, McKnight TR, Goldman SA, Weiss WA. Non-stem cell origin for oligodendroglioma. Cancer Cell. 2010 Dec 14; 18(6):669-82. PMID: 21156288; PMCID: PMC3031116.
      14. Silber J, Lim DA, Petritsch C, Persson AI, Maunakea AK, Yu M, Vandenberg SR, Ginzinger DG, James CD, Costello JF, Bergers G, Weiss WA, Alvarez-Buylla A, Hodgson JG. miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells. BMC Med. 2008; 6:14. PMID: 18577219; PMCID: PMC2443372.
      15. Erben V, Waldhuber M, Langer D, Fetka I, Jansen RP, Petritsch C. Asymmetric localization of the adaptor protein Miranda in neuroblasts is achieved by diffusion and sequential interaction of Myosin II and VI. J Cell Sci. 2008 May 1; 121(Pt 9):1403-14. PMID: 18398000.
        View in: PubMed
      16. Du R, Petritsch C, Lu K, Liu P, Haller A, Ganss R, Song H, Vandenberg S, Bergers G. Matrix metalloproteinase-2 regulates vascular patterning and growth affecting tumor cell survival and invasion in GBM. Neuro Oncol. 2008 Jun; 10(3):254-64. PMID: 18359864; PMCID: PMC2563048.
      17. Du R, Lu KV, Petritsch C, Liu P, Ganss R, Passegué E, Song H, Vandenberg S, Johnson RS, Werb Z, Bergers G. HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell. 2008 Mar; 13(3):206-20. PMID: 18328425; PMCID: PMC2643426.
      18. Waldhuber M, Emoto K, Petritsch C. The Drosophila caspase DRONC is required for metamorphosis and cell death in response to irradiation and developmental signals. Mech Dev. 2005 Jul; 122(7-8):914-27. PMID: 15922568.
        View in: PubMed
      19. Ye B, Petritsch C, Clark IE, Gavis ER, Jan LY, Jan YN. Nanos and Pumilio are essential for dendrite morphogenesis in Drosophila peripheral neurons. Curr Biol. 2004 Feb 17; 14(4):314-21. PMID: 14972682.
        View in: PubMed
      20. Petritsch C, Tavosanis G, Turck CW, Jan LY, Jan YN. The Drosophila myosin VI Jaguar is required for basal protein targeting and correct spindle orientation in mitotic neuroblasts. Dev Cell. 2003 Feb; 4(2):273-81. PMID: 12586070.
        View in: PubMed
      21. Petritsch C, Beug H, Balmain A, Oft M. TGF-beta inhibits p70 S6 kinase via protein phosphatase 2A to induce G(1) arrest. Genes Dev. 2000 Dec 15; 14(24):3093-101. PMID: 11124802; PMCID: PMC317138.
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