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    Clifford Lowell, MD, PhD

    TitleProfessor
    SchoolUCSF School of Medicine
    DepartmentLaboratory Medicine
    Address521 Parnassus Ave, Clinic Sci
    San Francisco CA 94143
    Phone415-476-5510
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      Other Positions
      TitleChair, Laboratory Medicine


      Collapse Biography 
      Collapse Education and Training
      Stanford UniversityBSBiology1979
      Johns Hopkins UniversityMD - PhDSchool of Medicine1986
      Johns Hopkins HospitalOsler Medical House OfficierMedicine1989
      University of California, San FranciscoClinical Fellowship Oncology1992
      University of California, San FranciscoPost-Doctoral Research FellowshipLaboratory: Harold Varmus1995
      Collapse Awards and Honors
      LLS2001Leukemia/Lymphoma Society Scholar
      FASEB2009Elected FASEB conference organizer
      Universite du Quebec2014Elected Advisory Board Neutrophil Immunity
      UCSF2015Distinguished Professorship

      Collapse Overview 
      Collapse Overview
      The Lowell laboratory studies tyrosine kinase based signal transduction in innate immune cells. Our general approach involves examination of innate immune function in knockout mice lacking various members of the Src-family or Syk family of tyrosine kinases. Many of these studies also involve use of mice lacking these kinases in specific hematopoietic lineages, such as neutrophils, macrophages or DCs, generated through Cre/Lox technology. We have also used this approach to study other tyrosine kinases (Pyk2/Fak) and intracellular signaling molecules (WASp, STIM1) in innate immune cells. Our major findings have illuminated the function of Src-family and Syk kinases in leukocyte integrin signaling – loss of these kinases results in significant defects in inflammatory and host defense functions mediated by integrins. We have found that leukocyte integrin signaling utilizes the same intracellular pathways initiated by classical immunoreceptors (such as Fc?Rs) by co-opting ITAM-containing adapter proteins. We have also demonstrated the important ways these kinases regulate innate immune cells in the setting of autoimmune and inflammatory diseases, using the Lyn kinase-deficient model. Ongoing studies also involve examination of tyrosine phosphatases (mainly SHP-1) in the counter regulation tyrosine kinases, especially in the setting of hematopoietic malignancy, as well as studies of calcium signaling proteins, using mice lacking these genes specifically in myeloid lineage cells. Publications total = 191


      Collapse ORNG Applications 
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      Collapse Awarded Grants
      Collapse Global Health

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Hang L, Blum AM, Kumar S, Urban JF, Mitreva M, Geary TG, Jardim A, Stevenson MM, Lowell CA, Weinstock JV. Downregulation of the Syk Signaling Pathway in Intestinal Dendritic Cells Is Sufficient To Induce Dendritic Cells That Inhibit Colitis. J Immunol. 2016 Oct 1; 197(7):2948-57. PMID: 27559049; PMCID: PMC5026942 [Available on 10/01/17].
      2. Wang H, Li M, Hung CY, Sinha M, Lee LM, Wiesner DL, LeBert V, Lerksuthirat T, Galles K, Suresh M, DeFranco AL, Lowell CA, Klein BS, Wüthrich M. MyD88 Shapes Vaccine Immunity by Extrinsically Regulating Survival of CD4+ T Cells during the Contraction Phase. PLoS Pathog. 2016 Aug; 12(8):e1005787. PMID: 27542117.
        View in: PubMed
      3. Sinha M, Lowell CA. Immune Defense Protein Expression in Highly Purified Mouse Lung Epithelial Cells. Am J Respir Cell Mol Biol. 2016 Jun; 54(6):802-13. PMID: 26574781.
        View in: PubMed
      4. Kerr SC, Fischer GJ, Sinha M, McCabe O, Palmer JM, Choera T, Yun Lim F, Wimmerova M, Carrington SD, Yuan S, Lowell CA, Oscarson S, Keller NP, Fahy JV. FleA Expression in Aspergillus fumigatus Is Recognized by Fucosylated Structures on Mucins and Macrophages to Prevent Lung Infection. PLoS Pathog. 2016 Apr; 12(4):e1005555. PMID: 27058347.
        View in: PubMed
      5. Németh T, Mócsai A, Lowell CA. Neutrophils in animal models of autoimmune disease. Semin Immunol. 2016 Apr; 28(2):174-86. PMID: 27067180.
        View in: PubMed
      6. Chen Z, Shojaee S, Buchner M, Geng H, Lee JW, Klemm L, Titz B, Graeber TG, Park E, Tan YX, Satterthwaite A, Paietta E, Hunger SP, Willman CL, Melnick A, Loh ML, Jung JU, Coligan JE, Bolland S, Mak TW, Limnander A, Jumaa H, Reth M, Weiss A, Lowell CA, Müschen M. Corrigendum: Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia. Nature. 2016 Jun 2; 534(7605):138. PMID: 26958840.
        View in: PubMed
      7. Rosales C, Demaurex N, Lowell CA, Uribe-Querol E. Neutrophils: Their Role in Innate and Adaptive Immunity. J Immunol Res. 2016; 2016:1469780. PMID: 27006954.
        View in: PubMed
      8. Volmering S, Block H, Boras M, Lowell CA, Zarbock A. The Neutrophil Btk Signalosome Regulates Integrin Activation during Sterile Inflammation. Immunity. 2016 Jan 19; 44(1):73-87. PMID: 26777396.
        View in: PubMed
      9. Freedman TS, Tan YX, Skrzypczynska KM, Manz BN, Sjaastad FV, Goodridge HS, Lowell CA, Weiss A. LynA regulates an inflammation-sensitive signaling checkpoint in macrophages. Elife. 2015; 4. PMID: 26517880; PMCID: PMC4626889.
      10. Yi T, Li J, Chen H, Wu J, An J, Xu Y, Hu Y, Lowell CA, Cyster JG. Splenic Dendritic Cells Survey Red Blood Cells for Missing Self-CD47 to Trigger Adaptive Immune Responses. Immunity. 2015 Oct 20; 43(4):764-75. PMID: 26453377; PMCID: PMC4618158 [Available on 10/20/16].
      11. Prakash A, Sundar SV, Zhu YG, Tran A, Lee JW, Lowell C, Hellman J. Lung Ischemia-Reperfusion is a Sterile Inflammatory Process Influenced by Commensal Microbiota in Mice. Shock. 2015 Sep; 44(3):272-9. PMID: 26196836; PMCID: PMC4537678 [Available on 09/01/16].
      12. Mazzi P, Caveggion E, Lapinet-Vera JA, Lowell CA, Berton G. The Src-Family Kinases Hck and Fgr Regulate Early Lipopolysaccharide-Induced Myeloid Cell Recruitment into the Lung and Their Ability To Secrete Chemokines. J Immunol. 2015 Sep 1; 195(5):2383-95. PMID: 26232427; PMCID: PMC4546890 [Available on 09/01/16].
      13. Stadtmann A, Block H, Volmering S, Abram C, Sohlbach C, Boras M, Lowell CA, Zarbock A. Cross-Talk between Shp1 and PIPKI? Controls Leukocyte Recruitment. J Immunol. 2015 Aug 1; 195(3):1152-61. PMID: 26101325; PMCID: PMC4506862 [Available on 08/01/16].
      14. Mócsai A, Walzog B, Lowell CA. Intracellular signalling during neutrophil recruitment. Cardiovasc Res. 2015 Aug 1; 107(3):373-85. PMID: 25998986; PMCID: PMC4502828.
      15. Chen Z, Shojaee S, Buchner M, Geng H, Lee JW, Klemm L, Titz B, Graeber TG, Park E, Tan YX, Satterthwaite A, Paietta E, Hunger SP, Willman CL, Melnick A, Loh ML, Jung JU, Coligan JE, Bolland S, Mak TW, Limnander A, Jumaa H, Reth M, Weiss A, Lowell CA, Müschen M. Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia. Nature. 2015 May 21; 521(7552):357-61. PMID: 25799995; PMCID: PMC4441554 [Available on 11/21/15].
      16. Clemens RA, Lowell CA. Store-operated calcium signaling in neutrophils. J Leukoc Biol. 2015 Oct; 98(4):497-502. PMID: 25714804.
        View in: PubMed
      17. Roubinian NH, Looney MR, Kor DJ, Lowell CA, Gajic O, Hubmayr RD, Gropper MA, Koenigsberg M, Wilson GA, Matthay MA, Toy P, Murphy EL. Cytokines and clinical predictors in distinguishing pulmonary transfusion reactions. Transfusion. 2015 Aug; 55(8):1838-46. PMID: 25702590; PMCID: PMC4536135 [Available on 08/01/16].
      18. Toy P, Bacchetti P, Grimes B, Gajic O, Murphy EL, Winters JL, Gropper MA, Hubmayr RD, Matthay MA, Wilson G, Koenigsberg M, Lee DC, Hirschler NV, Lowell CA, Schuller RM, Gandhi MJ, Norris PJ, Mair DC, Sanchez Rosen R, Looney MR. Recipient clinical risk factors predominate in possible transfusion-related acute lung injury. Transfusion. 2015 May; 55(5):947-52. PMID: 25488517; PMCID: PMC4428945 [Available on 05/01/16].
      19. Kovács M, Németh T, Jakus Z, Sitaru C, Simon E, Futosi K, Botz B, Helyes Z, Lowell CA, Mócsai A. The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment. J Exp Med. 2014 Sep 22; 211(10):1993-2011. PMID: 25225462; PMCID: PMC4172222.
      20. Looney MR, Roubinian N, Gajic O, Gropper MA, Hubmayr RD, Lowell CA, Bacchetti P, Wilson G, Koenigsberg M, Lee DC, Wu P, Grimes B, Norris PJ, Murphy EL, Gandhi MJ, Winters JL, Mair DC, Schuller RM, Hirschler NV, Rosen RS, Matthay MA, Toy P. Prospective study on the clinical course and outcomes in transfusion-related acute lung injury*. Crit Care Med. 2014 Jul; 42(7):1676-87. PMID: 24776608; PMCID: PMC4284060.
      21. Jaumouillé V, Farkash Y, Jaqaman K, Das R, Lowell CA, Grinstein S. Actin cytoskeleton reorganization by Syk regulates Fc? receptor responsiveness by increasing its lateral mobility and clustering. Dev Cell. 2014 Jun 9; 29(5):534-46. PMID: 24914558; PMCID: PMC4083245.
      22. Abram CL, Roberge GL, Hu Y, Lowell CA. Comparative analysis of the efficiency and specificity of myeloid-Cre deleting strains using ROSA-EYFP reporter mice. J Immunol Methods. 2014 Jun; 408:89-100. PMID: 24857755; PMCID: PMC4105345.
      23. Acín-Pérez R, Carrascoso I, Baixauli F, Roche-Molina M, Latorre-Pellicer A, Fernández-Silva P, Mittelbrunn M, Sanchez-Madrid F, Pérez-Martos A, Lowell CA, Manfredi G, Enríquez JA. ROS-triggered phosphorylation of complex II by Fgr kinase regulates cellular adaptation to fuel use. Cell Metab. 2014 Jun 3; 19(6):1020-33. PMID: 24856931; PMCID: PMC4274740.
      24. Suzuki R, Leach S, Liu W, Ralston E, Scheffel J, Zhang W, Lowell CA, Rivera J. Molecular editing of cellular responses by the high-affinity receptor for IgE. Science. 2014 Feb 28; 343(6174):1021-5. PMID: 24505132; PMCID: PMC4188507.
      25. Zhang H, Clemens RA, Liu F, Hu Y, Baba Y, Theodore P, Kurosaki T, Lowell CA. STIM1 calcium sensor is required for activation of the phagocyte oxidase during inflammation and host defense. Blood. 2014 Apr 3; 123(14):2238-49. PMID: 24493668; PMCID: PMC3975260.
      26. Hua Z, Gross AJ, Lamagna C, Ramos-Hernández N, Scapini P, Ji M, Shao H, Lowell CA, Hou B, DeFranco AL. Requirement for MyD88 signaling in B cells and dendritic cells for germinal center anti-nuclear antibody production in Lyn-deficient mice. J Immunol. 2014 Feb 1; 192(3):875-85. PMID: 24379120; PMCID: PMC4101002.
      27. Lamagna C, Hu Y, DeFranco AL, Lowell CA. B cell-specific loss of Lyn kinase leads to autoimmunity. J Immunol. 2014 Feb 1; 192(3):919-28. PMID: 24376269; PMCID: PMC3900234.
      28. Kadoch C, Li J, Wong VS, Chen L, Cha S, Munster P, Lowell CA, Shuman MA, Rubenstein JL. Complement activation and intraventricular rituximab distribution in recurrent central nervous system lymphoma. Clin Cancer Res. 2014 Feb 15; 20(4):1029-41. PMID: 24190981; PMCID: PMC3944388.
      29. Han J, Zhang G, Welch EJ, Liang Y, Fu J, Vogel SM, Lowell CA, Du X, Cheresh DA, Malik AB, Li Z. A critical role for Lyn kinase in strengthening endothelial integrity and barrier function. Blood. 2013 Dec 12; 122(25):4140-9. PMID: 24108461; PMCID: PMC3862279.
      30. Graham MT, Abram CL, Hu Y, Lowell CA. Expression of the TEL-Syk fusion protein in hematopoietic stem cells leads to rapidly fatal myelofibrosis in mice. PLoS One. 2013; 8(10):e77542. PMID: 24116232; PMCID: PMC3792906.
      31. Mayadas TN, Cullere X, Lowell CA. The multifaceted functions of neutrophils. Annu Rev Pathol. 2014; 9:181-218. PMID: 24050624; PMCID: PMC4277181.
      32. Albanesi M, Mancardi DA, Jönsson F, Iannascoli B, Fiette L, Di Santo JP, Lowell CA, Bruhns P. Neutrophils mediate antibody-induced antitumor effects in mice. Blood. 2013 Oct 31; 122(18):3160-4. PMID: 23980063; PMCID: PMC3814733.
      33. Lamagna C, Scapini P, van Ziffle JA, DeFranco AL, Lowell CA. Hyperactivated MyD88 signaling in dendritic cells, through specific deletion of Lyn kinase, causes severe autoimmunity and inflammation. Proc Natl Acad Sci U S A. 2013 Aug 27; 110(35):E3311-20. PMID: 23940344; PMCID: PMC3761623.
      34. Vérollet C, Gallois A, Dacquin R, Lastrucci C, Pandruvada SN, Ortega N, Poincloux R, Behar A, Cougoule C, Lowell C, Al Saati T, Jurdic P, Maridonneau-Parini I. Hck contributes to bone homeostasis by controlling the recruitment of osteoclast precursors. FASEB J. 2013 Sep; 27(9):3608-18. PMID: 23742809; PMCID: PMC4046168.
      35. Rubenstein JL, Wong VS, Kadoch C, Gao HX, Barajas R, Chen L, Josephson SA, Scott B, Douglas V, Maiti M, Kaplan LD, Treseler PA, Cha S, Hwang JH, Cinque P, Cyster JG, Lowell C. CXCL13 plus interleukin 10 is highly specific for the diagnosis of CNS lymphoma. Blood. 2013 Jun 6; 121(23):4740-8. PMID: 23570798; PMCID: PMC3674672.
      36. Abram CL, Roberge GL, Pao LI, Neel BG, Lowell CA. Distinct roles for neutrophils and dendritic cells in inflammation and autoimmunity in motheaten mice. Immunity. 2013 Mar 21; 38(3):489-501. PMID: 23521885; PMCID: PMC3613338.
      37. Fumagalli L, Campa CC, Germena G, Lowell CA, Hirsch E, Berton G. Class I phosphoinositide-3-kinases and SRC kinases play a nonredundant role in regulation of adhesion-independent and -dependent neutrophil reactive oxygen species generation. J Immunol. 2013 Apr 1; 190(7):3648-60. PMID: 23447687; PMCID: PMC4280093.
      38. Heit B, Kim H, Cosío G, Castaño D, Collins R, Lowell CA, Kain KC, Trimble WS, Grinstein S. Multimolecular signaling complexes enable Syk-mediated signaling of CD36 internalization. Dev Cell. 2013 Feb 25; 24(4):372-83. PMID: 23395392; PMCID: PMC3586299.
      39. Rubenstein JL, Li J, Chen L, Advani R, Drappatz J, Gerstner E, Batchelor T, Krouwer H, Hwang J, Auerback G, Kadoch C, Lowell C, Munster P, Cha S, Shuman MA, Damon LE. Multicenter phase 1 trial of intraventricular immunochemotherapy in recurrent CNS lymphoma. Blood. 2013 Jan 31; 121(5):745-51. PMID: 23197589; PMCID: PMC3563362.
      40. Jhingran A, Mar KB, Kumasaka DK, Knoblaugh SE, Ngo LY, Segal BH, Iwakura Y, Lowell CA, Hamerman JA, Lin X, Hohl TM. Tracing conidial fate and measuring host cell antifungal activity using a reporter of microbial viability in the lung. Cell Rep. 2012 Dec 27; 2(6):1762-73. PMID: 23200858; PMCID: PMC3712646.
      41. Alenghat FJ, Baca QJ, Rubin NT, Pao LI, Matozaki T, Lowell CA, Golan DE, Neel BG, Swanson KD. Macrophages require Skap2 and Sirpa for integrin-stimulated cytoskeletal rearrangement. J Cell Sci. 2012 Nov 15; 125(Pt 22):5535-45. PMID: 22976304; PMCID: PMC3561861.
      42. Ma J, Becker C, Lowell CA, Underhill DM. Dectin-1-triggered recruitment of light chain 3 protein to phagosomes facilitates major histocompatibility complex class II presentation of fungal-derived antigens. J Biol Chem. 2012 Oct 5; 287(41):34149-56. PMID: 22902620; PMCID: PMC3464523.
      43. Séverin S, Nash CA, Mori J, Zhao Y, Abram C, Lowell CA, Senis YA, Watson SP. Distinct and overlapping functional roles of Src family kinases in mouse platelets. J Thromb Haemost. 2012 Aug; 10(8):1631-45. PMID: 22694307; PMCID: PMC4280098.
      44. Block H, Herter JM, Rossaint J, Stadtmann A, Kliche S, Lowell CA, Zarbock A. Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury. J Exp Med. 2012 Feb 13; 209(2):407-21. PMID: 22291096; PMCID: PMC3280874.
      45. Weiskopf RB, Feiner J, Toy P, Twiford J, Shimabukuro D, Lieberman J, Looney MR, Lowell CA, Gropper MA. Fresh and stored red blood cell transfusion equivalently induce subclinical pulmonary gas exchange deficit in normal humans. Anesth Analg. 2012 Mar; 114(3):511-9. PMID: 22262647; PMCID: PMC3927839.
      46. Lowell CA, Mayadas TN. Overview: studying integrins in vivo. Methods Mol Biol. 2012; 757:369-97. PMID: 21909923; PMCID: PMC3248401.
      47. Ni M, MacFarlane AW, Toft M, Lowell CA, Campbell KS, Hamerman JA. B-cell adaptor for PI3K (BCAP) negatively regulates Toll-like receptor signaling through activation of PI3K. Proc Natl Acad Sci U S A. 2012 Jan 3; 109(1):267-72. PMID: 22187458; PMCID: PMC3252908.
      48. Toy P, Gajic O, Bacchetti P, Looney MR, Gropper MA, Hubmayr R, Lowell CA, Norris PJ, Murphy EL, Weiskopf RB, Wilson G, Koenigsberg M, Lee D, Schuller R, Wu P, Grimes B, Gandhi MJ, Winters JL, Mair D, Hirschler N, Sanchez Rosen R, Matthay MA. Transfusion-related acute lung injury: incidence and risk factors. Blood. 2012 Feb 16; 119(7):1757-67. PMID: 22117051; PMCID: PMC3286351.
      49. Zhu JW, Doan K, Park J, Chau AH, Zhang H, Lowell CA, Weiss A. Receptor-like tyrosine phosphatases CD45 and CD148 have distinct functions in chemoattractant-mediated neutrophil migration and response to S. aureus. Immunity. 2011 Nov 23; 35(5):757-69. PMID: 22078799; PMCID: PMC3245876.
      50. Xu X, Zhang H, Song Y, Lynch SV, Lowell CA, Wiener-Kronish JP, Caughey GH. Strain-dependent induction of neutrophil histamine production and cell death by Pseudomonas aeruginosa. J Leukoc Biol. 2012 Feb; 91(2):275-84. PMID: 22075928; PMCID: PMC3290427.
      51. Elliott ER, Van Ziffle JA, Scapini P, Sullivan BM, Locksley RM, Lowell CA. Deletion of Syk in neutrophils prevents immune complex arthritis. J Immunol. 2011 Oct 15; 187(8):4319-30. PMID: 21918195; PMCID: PMC3186826.
      52. Scapini P, Lamagna C, Hu Y, Lee K, Tang Q, DeFranco AL, Lowell CA. B cell-derived IL-10 suppresses inflammatory disease in Lyn-deficient mice. Proc Natl Acad Sci U S A. 2011 Oct 11; 108(41):E823-32. PMID: 21911371; PMCID: PMC3193193.
      53. Andre P, Morooka T, Sim D, Abe K, Lowell C, Nanda N, Delaney S, Siu G, Yan Y, Hollenbach S, Pandey A, Gao H, Wang Y, Nakajima K, Parikh SA, Shi C, Phillips D, Owen W, Sinha U, Simon DI. Critical role for Syk in responses to vascular injury. Blood. 2011 Nov 3; 118(18):5000-10. PMID: 21881044; PMCID: PMC3208305.
      54. Guiet R, Van Goethem E, Cougoule C, Balor S, Valette A, Al Saati T, Lowell CA, Le Cabec V, Maridonneau-Parini I. The process of macrophage migration promotes matrix metalloproteinase-independent invasion by tumor cells. J Immunol. 2011 Oct 1; 187(7):3806-14. PMID: 21880978; PMCID: PMC4276309.
      55. Cai H, Smith DA, Memarzadeh S, Lowell CA, Cooper JA, Witte ON. Differential transformation capacity of Src family kinases during the initiation of prostate cancer. Proc Natl Acad Sci U S A. 2011 Apr 19; 108(16):6579-84. PMID: 21464326; PMCID: PMC3080985.
      56. Lowell CA. Neutrophils give us a shock. J Clin Invest. 2011 Apr; 121(4):1260-3. PMID: 21436575; PMCID: PMC3069799.
      57. Ma G, Pan PY, Eisenstein S, Divino CM, Lowell CA, Takai T, Chen SH. Paired immunoglobin-like receptor-B regulates the suppressive function and fate of myeloid-derived suppressor cells. Immunity. 2011 Mar 25; 34(3):385-95. PMID: 21376641; PMCID: PMC3064726.
      58. Lowell CA. Src-family and Syk kinases in activating and inhibitory pathways in innate immune cells: signaling cross talk. Cold Spring Harb Perspect Biol. 2011 Mar; 3(3). PMID: 21068150; PMCID: PMC3039931.
      59. Nelson MP, Christmann BS, Werner JL, Metz AE, Trevor JL, Lowell CA, Steele C. IL-33 and M2a alveolar macrophages promote lung defense against the atypical fungal pathogen Pneumocystis murina. J Immunol. 2011 Feb 15; 186(4):2372-81. PMID: 21220696; PMCID: PMC4274743.
      60. Kamen LA, Schlessinger J, Lowell CA. Pyk2 is required for neutrophil degranulation and host defense responses to bacterial infection. J Immunol. 2011 Feb 1; 186(3):1656-65. PMID: 21187437; PMCID: PMC3248398.
      61. Yamada M, Gomez JC, Chugh PE, Lowell CA, Dinauer MC, Dittmer DP, Doerschuk CM. Interferon-? production by neutrophils during bacterial pneumonia in mice. Am J Respir Crit Care Med. 2011 May 15; 183(10):1391-401. PMID: 21169470; PMCID: PMC3114063.
      62. Tavares RM, Turer EE, Liu CL, Advincula R, Scapini P, Rhee L, Barrera J, Lowell CA, Utz PJ, Malynn BA, Ma A. The ubiquitin modifying enzyme A20 restricts B cell survival and prevents autoimmunity. Immunity. 2010 Aug 27; 33(2):181-91. PMID: 20705491; PMCID: PMC2931361.
      63. Scapini P, Hu Y, Chu CL, Migone TS, Defranco AL, Cassatella MA, Lowell CA. Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice. J Exp Med. 2010 Aug 2; 207(8):1757-73. PMID: 20624892; PMCID: PMC2916124.
      64. Li Z, Zhang G, Liu J, Stojanovic A, Ruan C, Lowell CA, Du X. An important role of the SRC family kinase Lyn in stimulating platelet granule secretion. J Biol Chem. 2010 Apr 23; 285(17):12559-70. PMID: 20189992; PMCID: PMC2857081.
      65. Nedunuri KV, Lowell C, Meade W, Vonderheide AP, Shann JR. Management practices and phytoremediation by native grasses. Int J Phytoremediation. 2010 Feb; 12(2):200-14. PMID: 20734616.
        View in: PubMed
      66. Baruzzi A, Iacobucci I, Soverini S, Lowell CA, Martinelli G, Berton G. c-Abl and Src-family kinases cross-talk in regulation of myeloid cell migration. FEBS Lett. 2010 Jan 4; 584(1):15-21. PMID: 19903482; PMCID: PMC4454382.
      67. Cougoule C, Le Cabec V, Poincloux R, Al Saati T, Mège JL, Tabouret G, Lowell CA, Laviolette-Malirat N, Maridonneau-Parini I. Three-dimensional migration of macrophages requires Hck for podosome organization and extracellular matrix proteolysis. Blood. 2010 Feb 18; 115(7):1444-52. PMID: 19897576.
        View in: PubMed
      68. Hamerman JA, Ni M, Killebrew JR, Chu CL, Lowell CA. The expanding roles of ITAM adapters FcRgamma and DAP12 in myeloid cells. Immunol Rev. 2009 Nov; 232(1):42-58. PMID: 19909355; PMCID: PMC3248395.
      69. Looney MR, Nguyen JX, Hu Y, Van Ziffle JA, Lowell CA, Matthay MA. Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury. J Clin Invest. 2009 Nov; 119(11):3450-61. PMID: 19809160.
        View in: PubMed
      70. Van Ziffle JA, Lowell CA. Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infection. Blood. 2009 Nov 26; 114(23):4871-82. PMID: 19797524; PMCID: PMC2786293.
      71. Weiskopf RB, Yau R, Sanchez R, Lowell C, Toy P. Microarray kit analysis of cytokines in blood product units and segments. Transfusion. 2009 Nov; 49(11):2269-75. PMID: 19548981; PMCID: PMC2783862.
      72. Abram CL, Lowell CA. Leukocyte adhesion deficiency syndrome: a controversy solved. Immunol Cell Biol. 2009 Aug-Sep; 87(6):440-2. PMID: 19417769; PMCID: PMC4464832.
      73. Kadoch C, Dinca EB, Voicu R, Chen L, Nguyen D, Parikh S, Karrim J, Shuman MA, Lowell CA, Treseler PA, James CD, Rubenstein JL. Pathologic correlates of primary central nervous system lymphoma defined in an orthotopic xenograft model. Clin Cancer Res. 2009 Mar 15; 15(6):1989-97. PMID: 19276270; PMCID: PMC4372389.
      74. Nelson MP, Metz AE, Li S, Lowell CA, Steele C. The absence of Hck, Fgr, and Lyn tyrosine kinases augments lung innate immune responses to Pneumocystis murina. Infect Immun. 2009 May; 77(5):1790-7. PMID: 19255189; PMCID: PMC2681740.
      75. Scapini P, Pereira S, Zhang H, Lowell CA. Multiple roles of Lyn kinase in myeloid cell signaling and function. Immunol Rev. 2009 Mar; 228(1):23-40. PMID: 19290919; PMCID: PMC3248569.
      76. N'Diaye EN, Branda CS, Branda SS, Nevarez L, Colonna M, Lowell C, Hamerman JA, Seaman WE. TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria. J Cell Biol. 2009 Jan 26; 184(2):215-23. PMID: 19171755; PMCID: PMC2654305.
      77. Miller AL, Zhang C, Shokat KM, Lowell CA. Generation of a novel system for studying spleen tyrosine kinase function in macrophages and B cells. J Immunol. 2009 Jan 15; 182(2):988-98. PMID: 19124742; PMCID: PMC3248399.
      78. Abram CL, Lowell CA. The ins and outs of leukocyte integrin signaling. Annu Rev Immunol. 2009; 27:339-62. PMID: 19302044; PMCID: PMC3248397.
      79. Sarantos MR, Zhang H, Schaff UY, Dixit N, Hayenga HN, Lowell CA, Simon SI. Transmigration of neutrophils across inflamed endothelium is signaled through LFA-1 and Src family kinase. J Immunol. 2008 Dec 15; 181(12):8660-9. PMID: 19050286; PMCID: PMC4457456.
      80. Ng G, Sharma K, Ward SM, Desrosiers MD, Stephens LA, Schoel WM, Li T, Lowell CA, Ling CC, Amrein MW, Shi Y. Receptor-independent, direct membrane binding leads to cell-surface lipid sorting and Syk kinase activation in dendritic cells. Immunity. 2008 Nov 14; 29(5):807-18. PMID: 18993083; PMCID: PMC2642965.
      81. Zarbock A, Abram CL, Hundt M, Altman A, Lowell CA, Ley K. PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcR gamma to induce slow leukocyte rolling. J Exp Med. 2008 Sep 29; 205(10):2339-47. PMID: 18794338; PMCID: PMC2556779.
      82. Liu J, Joglekar M, Ware J, Fitzgerald ME, Lowell CA, Berndt MC, Gartner TK. Evaluation of the physiological significance of botrocetin/ von Willebrand factor in vitro signaling. J Thromb Haemost. 2008 Nov; 6(11):1915-22. PMID: 18752568; PMCID: PMC2982674.
      83. Paul R, Obermaier B, Van Ziffle J, Angele B, Pfister HW, Lowell CA, Koedel U. Myeloid Src kinases regulate phagocytosis and oxidative burst in pneumococcal meningitis by activating NADPH oxidase. J Leukoc Biol. 2008 Oct; 84(4):1141-50. PMID: 18625913; PMCID: PMC2538596.
      84. Yin H, Liu J, Li Z, Berndt MC, Lowell CA, Du X. Src family tyrosine kinase Lyn mediates VWF/GPIb-IX-induced platelet activation via the cGMP signaling pathway. Blood. 2008 Aug 15; 112(4):1139-46. PMID: 18550847; PMCID: PMC2515128.
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      86. Xiao W, Hong H, Kawakami Y, Lowell CA, Kawakami T. Regulation of myeloproliferation and M2 macrophage programming in mice by Lyn/Hck, SHIP, and Stat5. J Clin Invest. 2008 Mar; 118(3):924-34. PMID: 18246197; PMCID: PMC2214849.
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      91. Zarbock A, Lowell CA, Ley K. Spleen tyrosine kinase Syk is necessary for E-selectin-induced alpha(L)beta(2) integrin-mediated rolling on intercellular adhesion molecule-1. Immunity. 2007 Jun; 26(6):773-83. PMID: 17543554; PMCID: PMC2600878.
      92. Hong H, Kitaura J, Xiao W, Horejsi V, Ra C, Lowell CA, Kawakami Y, Kawakami T. The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn. Blood. 2007 Oct 1; 110(7):2511-9. PMID: 17513616; PMCID: PMC1988937.
      93. Guo B, Blair D, Chiles TC, Lowell CA, Rothstein TL. Cutting Edge: B cell receptor (BCR) cross-talk: the IL-4-induced alternate pathway for BCR signaling operates in parallel with the classical pathway, is sensitive to Rottlerin, and depends on Lyn. J Immunol. 2007 Apr 15; 178(8):4726-30. PMID: 17404251.
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      94. Fumagalli L, Zhang H, Baruzzi A, Lowell CA, Berton G. The Src family kinases Hck and Fgr regulate neutrophil responses to N-formyl-methionyl-leucyl-phenylalanine. J Immunol. 2007 Mar 15; 178(6):3874-85. PMID: 17339487.
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      96. Xu X, Zhang D, Zhang H, Wolters PJ, Killeen NP, Sullivan BM, Locksley RM, Lowell CA, Caughey GH. Neutrophil histamine contributes to inflammation in mycoplasma pneumonia. J Exp Med. 2006 Dec 25; 203(13):2907-17. PMID: 17158962; PMCID: PMC2118183.
      97. Evangelista V, Pamuklar Z, Piccoli A, Manarini S, Dell'elba G, Pecce R, Martelli N, Federico L, Rojas M, Berton G, Lowell CA, Totani L, Smyth SS. Src family kinases mediate neutrophil adhesion to adherent platelets. Blood. 2007 Mar 15; 109(6):2461-9. PMID: 17095622; PMCID: PMC1852189.
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      99. Zhang H, Schaff UY, Green CE, Chen H, Sarantos MR, Hu Y, Wara D, Simon SI, Lowell CA. Impaired integrin-dependent function in Wiskott-Aldrich syndrome protein-deficient murine and human neutrophils. Immunity. 2006 Aug; 25(2):285-95. PMID: 16901726.
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      100. Hirahashi J, Mekala D, Van Ziffle J, Xiao L, Saffaripour S, Wagner DD, Shapiro SD, Lowell C, Mayadas TN. Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathy. Immunity. 2006 Aug; 25(2):271-83. PMID: 16872848.
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      101. Giagulli C, Ottoboni L, Caveggion E, Rossi B, Lowell C, Constantin G, Laudanna C, Berton G. The Src family kinases Hck and Fgr are dispensable for inside-out, chemoattractant-induced signaling regulating beta 2 integrin affinity and valency in neutrophils, but are required for beta 2 integrin-mediated outside-in signaling involved in sustained adhesion. J Immunol. 2006 Jul 1; 177(1):604-11. PMID: 16785558.
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      102. Mermel CH, McLemore ML, Liu F, Pereira S, Woloszynek J, Lowell CA, Link DC. Src family kinases are important negative regulators of G-CSF-dependent granulopoiesis. Blood. 2006 Oct 15; 108(8):2562-8. PMID: 16772601; PMCID: PMC1895577.
      103. Looney MR, Su X, Van Ziffle JA, Lowell CA, Matthay MA. Neutrophils and their Fc gamma receptors are essential in a mouse model of transfusion-related acute lung injury. J Clin Invest. 2006 Jun; 116(6):1615-23. PMID: 16710475; PMCID: PMC1462945.
      104. Karur VG, Lowell CA, Besmer P, Agosti V, Wojchowski DM. Lyn kinase promotes erythroblast expansion and late-stage development. Blood. 2006 Sep 1; 108(5):1524-32. PMID: 16705093; PMCID: PMC1895506.
      105. Totani L, Piccoli A, Manarini S, Federico L, Pecce R, Martelli N, Cerletti C, Piccardoni P, Lowell CA, Smyth SS, Berton G, Evangelista V. Src-family kinases mediate an outside-in signal necessary for beta2 integrins to achieve full activation and sustain firm adhesion of polymorphonuclear leucocytes tethered on E-selectin. Biochem J. 2006 May 15; 396(1):89-98. PMID: 16433632; PMCID: PMC1449987.
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      108. Yu M, Lowell CA, Neel BG, Gu H. Scaffolding adapter Grb2-associated binder 2 requires Syk to transmit signals from FcepsilonRI. J Immunol. 2006 Feb 15; 176(4):2421-9. PMID: 16456001.
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      109. Sasanuma H, Tatsuno A, Hidano S, Ohshima K, Matsuzaki Y, Hayashi K, Lowell CA, Kitamura D, Goitsuka R. Dual function for the adaptor MIST in IFN-gamma production by NK and CD4+NKT cells regulated by the Src kinase Fgr. Blood. 2006 May 1; 107(9):3647-55. PMID: 16439675.
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      110. Hernandez-Hansen V, Bard JD, Tarleton CA, Wilder JA, Lowell CA, Wilson BS, Oliver JM. Increased expression of genes linked to FcepsilonRI Signaling and to cytokine and chemokine production in Lyn-deficient mast cells. J Immunol. 2005 Dec 15; 175(12):7880-8. PMID: 16339523.
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      111. Xiao W, Nishimoto H, Hong H, Kitaura J, Nunomura S, Maeda-Yamamoto M, Kawakami Y, Lowell CA, Ra C, Kawakami T. Positive and negative regulation of mast cell activation by Lyn via the FcepsilonRI. J Immunol. 2005 Nov 15; 175(10):6885-92. PMID: 16272347; PMCID: PMC1415265.
      112. De Franceschi L, Villa-Moruzzi E, Biondani A, Siciliano A, Brugnara C, Alper SL, Lowell CA, Berton G. Regulation of K-Cl cotransport by protein phosphatase 1alpha in mouse erythrocytes. Pflugers Arch. 2006 Mar; 451(6):760-8. PMID: 16283202.
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      113. Zhu QS, Xia L, Mills GB, Lowell CA, Touw IP, Corey SJ. G-CSF induced reactive oxygen species involves Lyn-PI3-kinase-Akt and contributes to myeloid cell growth. Blood. 2006 Mar 1; 107(5):1847-56. PMID: 16282349; PMCID: PMC1895701.
      114. Lee JY, Lowell CA, Lemay DG, Youn HS, Rhee SH, Sohn KH, Jang B, Ye J, Chung JH, Hwang DH. The regulation of the expression of inducible nitric oxide synthase by Src-family tyrosine kinases mediated through MyD88-independent signaling pathways of Toll-like receptor 4. Biochem Pharmacol. 2005 Oct 15; 70(8):1231-40. PMID: 16140274.
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      115. Chu CL, Lowell CA. The Lyn tyrosine kinase differentially regulates dendritic cell generation and maturation. J Immunol. 2005 Sep 1; 175(5):2880-9. PMID: 16116174.
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      117. Hamerman JA, Tchao NK, Lowell CA, Lanier LL. Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12. Nat Immunol. 2005 Jun; 6(6):579-86. PMID: 15895090; PMCID: PMC1282462.
      118. Kitaura J, Eto K, Kinoshita T, Kawakami Y, Leitges M, Lowell CA, Kawakami T. Regulation of highly cytokinergic IgE-induced mast cell adhesion by Src, Syk, Tec, and protein kinase C family kinases. J Immunol. 2005 Apr 15; 174(8):4495-504. PMID: 15814670.
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      120. Lee TH, Wen L, Montalvo L, Esho O, Lowell C, Reed W, Busch M. Minimum conditions of major histocompatibility complex compatibility and recipient immune compromise required to establish donor white blood cell persistence in a murine transfusion model. Transfusion. 2005 Mar; 45(3):301-14. PMID: 15752147.
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      121. Zhang H, Meng F, Chu CL, Takai T, Lowell CA. The Src family kinases Hck and Fgr negatively regulate neutrophil and dendritic cell chemokine signaling via PIR-B. Immunity. 2005 Feb; 22(2):235-46. PMID: 15723811.
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      122. Continolo S, Baruzzi A, Majeed M, Caveggion E, Fumagalli L, Lowell CA, Berton G. The proto-oncogene Fgr regulates cell migration and this requires its plasma membrane localization. Exp Cell Res. 2005 Jan 15; 302(2):253-69. PMID: 15561106.
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      125. Tassiulas I, Hu X, Ho H, Kashyap Y, Paik P, Hu Y, Lowell CA, Ivashkiv LB. Amplification of IFN-alpha-induced STAT1 activation and inflammatory function by Syk and ITAM-containing adaptors. Nat Immunol. 2004 Nov; 5(11):1181-9. PMID: 15467722.
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      126. Kitaura J, Xiao W, Maeda-Yamamoto M, Kawakami Y, Lowell CA, Kawakami T. Early divergence of Fc epsilon receptor I signals for receptor up-regulation and internalization from degranulation, cytokine production, and survival. J Immunol. 2004 Oct 1; 173(7):4317-23. PMID: 15383560.
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      127. Jakus Z, Berton G, Ligeti E, Lowell CA, Mócsai A. Responses of neutrophils to anti-integrin antibodies depends on costimulation through low affinity Fc gamma Rs: full activation requires both integrin and nonintegrin signals. J Immunol. 2004 Aug 1; 173(3):2068-77. PMID: 15265942.
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      129. Chou WH, Choi DS, Zhang H, Mu D, McMahon T, Kharazia VN, Lowell CA, Ferriero DM, Messing RO. Neutrophil protein kinase Cdelta as a mediator of stroke-reperfusion injury. J Clin Invest. 2004 Jul; 114(1):49-56. PMID: 15232611; PMCID: PMC437973.
      130. Hernandez-Hansen V, Smith AJ, Surviladze Z, Chigaev A, Mazel T, Kalesnikoff J, Lowell CA, Krystal G, Sklar LA, Wilson BS, Oliver JM. Dysregulated FcepsilonRI signaling and altered Fyn and SHIP activities in Lyn-deficient mast cells. J Immunol. 2004 Jul 1; 173(1):100-12. PMID: 15210764.
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      131. Scapini P, Morini M, Tecchio C, Minghelli S, Di Carlo E, Tanghetti E, Albini A, Lowell C, Berton G, Noonan DM, Cassatella MA. CXCL1/macrophage inflammatory protein-2-induced angiogenesis in vivo is mediated by neutrophil-derived vascular endothelial growth factor-A. J Immunol. 2004 Apr 15; 172(8):5034-40. PMID: 15067085.
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      132. Mócsai A, Humphrey MB, Van Ziffle JA, Hu Y, Burghardt A, Spusta SC, Majumdar S, Lanier LL, Lowell CA, Nakamura MC. The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase. Proc Natl Acad Sci U S A. 2004 Apr 20; 101(16):6158-63. PMID: 15073337; PMCID: PMC395939.
      133. Newbrough SA, Mocsai A, Clemens RA, Wu JN, Silverman MA, Singer AL, Lowell CA, Koretzky GA. SLP-76 regulates Fcgamma receptor and integrin signaling in neutrophils. Immunity. 2003 Nov; 19(5):761-9. PMID: 14614862.
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      134. Kitaura J, Song J, Tsai M, Asai K, Maeda-Yamamoto M, Mocsai A, Kawakami Y, Liu FT, Lowell CA, Barisas BG, Galli SJ, Kawakami T. Evidence that IgE molecules mediate a spectrum of effects on mast cell survival and activation via aggregation of the FcepsilonRI. Proc Natl Acad Sci U S A. 2003 Oct 28; 100(22):12911-6. PMID: 14569021; PMCID: PMC240718.
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      136. Whyburn LR, Halcomb KE, Contreras CM, Lowell CA, Witte ON, Satterthwaite AB. Reduced dosage of Bruton's tyrosine kinase uncouples B cell hyperresponsiveness from autoimmunity in lyn-/- mice. J Immunol. 2003 Aug 15; 171(4):1850-8. PMID: 12902486.
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      137. Pereira S, Lowell C. The Lyn tyrosine kinase negatively regulates neutrophil integrin signaling. J Immunol. 2003 Aug 1; 171(3):1319-27. PMID: 12874221.
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      138. Chen H, Mocsai A, Zhang H, Ding RX, Morisaki JH, White M, Rothfork JM, Heiser P, Colucci-Guyon E, Lowell CA, Gresham HD, Allen PM, Brown EJ. Role for plastin in host defense distinguishes integrin signaling from cell adhesion and spreading. Immunity. 2003 Jul; 19(1):95-104. PMID: 12871642.
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      139. Caveggion E, Continolo S, Pixley FJ, Stanley ER, Bowtell DD, Lowell CA, Berton G. Expression and tyrosine phosphorylation of Cbl regulates macrophage chemokinetic and chemotactic movement. J Cell Physiol. 2003 May; 195(2):276-89. PMID: 12652654.
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      140. Saijo K, Schmedt C, Su IH, Karasuyama H, Lowell CA, Reth M, Adachi T, Patke A, Santana A, Tarakhovsky A. Essential role of Src-family protein tyrosine kinases in NF-kappaB activation during B cell development. Nat Immunol. 2003 Mar; 4(3):274-9. PMID: 12563261.
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      142. Abtahian F, Guerriero A, Sebzda E, Lu MM, Zhou R, Mocsai A, Myers EE, Huang B, Jackson DG, Ferrari VA, Tybulewicz V, Lowell CA, Lepore JJ, Koretzky GA, Kahn ML. Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk. Science. 2003 Jan 10; 299(5604):247-51. PMID: 12522250; PMCID: PMC2982679.
      143. Zeng M, Zhang H, Lowell C, He P. Tumor necrosis factor-alpha-induced leukocyte adhesion and microvessel permeability. Am J Physiol Heart Circ Physiol. 2002 Dec; 283(6):H2420-30. PMID: 12388263.
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      150. Dan Q, Sanchez R, Delgado C, Wepsic HT, Morgan K, Chen Y, Jeffes EW, Lowell CA, Morgan TR, Jadus MR. Non-immunogenic murine hepatocellular carcinoma Hepa1-6 cells expressing the membrane form of macrophage colony stimulating factor are rejected in vivo and lead to CD8+ T-cell immunity against the parental tumor. Mol Ther. 2001 Nov; 4(5):427-37. PMID: 11708879.
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      151. Hanna Z, Weng X, Kay DG, Poudrier J, Lowell C, Jolicoeur P. The pathogenicity of human immunodeficiency virus (HIV) type 1 Nef in CD4C/HIV transgenic mice is abolished by mutation of its SH3-binding domain, and disease development is delayed in the absence of Hck. J Virol. 2001 Oct; 75(19):9378-92. PMID: 11533201; PMCID: PMC114506.
      152. Vines CM, Potter JW, Xu Y, Geahlen RL, Costello PS, Tybulewicz VL, Lowell CA, Chang PW, Gresham HD, Willman CL. Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr. Immunity. 2001 Oct; 15(4):507-19. PMID: 11672534.
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      153. Hasegawa M, Fujimoto M, Poe JC, Steeber DA, Lowell CA, Tedder TF. A CD19-dependent signaling pathway regulates autoimmunity in Lyn-deficient mice. J Immunol. 2001 Sep 1; 167(5):2469-78. PMID: 11509585.
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      154. O'Laughlin-Bunner B, Radosevic N, Taylor ML, DeBerry C, Metcalfe DD, Zhou M, Lowell C, Linnekin D. Lyn is required for normal stem cell factor-induced proliferation and chemotaxis of primary hematopoietic cells. Blood. 2001 Jul 15; 98(2):343-50. PMID: 11435302.
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      155. Pereira S, Zhou M, Mócsai A, Lowell C. Resting murine neutrophils express functional alpha 4 integrins that signal through Src family kinases. J Immunol. 2001 Mar 15; 166(6):4115-23. PMID: 11238661.
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      156. Yu CC, Yen TS, Lowell CA, DeFranco AL. Lupus-like kidney disease in mice deficient in the Src family tyrosine kinases Lyn and Fyn. Curr Biol. 2001 Jan 9; 11(1):34-8. PMID: 11166177.
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      157. Quek LS, Pasquet JM, Hers I, Cornall R, Knight G, Barnes M, Hibbs ML, Dunn AR, Lowell CA, Watson SP. Fyn and Lyn phosphorylate the Fc receptor gamma chain downstream of glycoprotein VI in murine platelets, and Lyn regulates a novel feedback pathway. Blood. 2000 Dec 15; 96(13):4246-53. PMID: 11110698.
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      158. Pasquet JM, Quek L, Pasquet S, Poole A, Matthews JR, Lowell C, Watson SP. Evidence of a role for SHP-1 in platelet activation by the collagen receptor glycoprotein VI. J Biol Chem. 2000 Sep 15; 275(37):28526-31. PMID: 10871605.
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      159. Kawakami Y, Kitaura J, Satterthwaite AB, Kato RM, Asai K, Hartman SE, Maeda-Yamamoto M, Lowell CA, Rawlings DJ, Witte ON, Kawakami T. Redundant and opposing functions of two tyrosine kinases, Btk and Lyn, in mast cell activation. J Immunol. 2000 Aug 1; 165(3):1210-9. PMID: 10903718.
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      164. Weinstein SL, Finn AJ, Davé SH, Meng F, Lowell CA, Sanghera JS, DeFranco AL. Phosphatidylinositol 3-kinase and mTOR mediate lipopolysaccharide-stimulated nitric oxide production in macrophages via interferon-beta. J Leukoc Biol. 2000 Mar; 67(3):405-14. PMID: 10733102.
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      167. Brady KA, Atwater SK, Lowell CA. Flow cytometric detection of CD10 (cALLA) on peripheral blood B lymphocytes of neonates. Br J Haematol. 1999 Dec; 107(4):712-5. PMID: 10606874.
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      172. Satterthwaite AB, Lowell CA, Khan WN, Sideras P, Alt FW, Witte ON. Independent and opposing roles for Btk and lyn in B and myeloid signaling pathways. J Exp Med. 1998 Sep 7; 188(5):833-44. PMID: 9730885; PMCID: PMC2213392.
      173. Meng F, Lowell CA. A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration. EMBO J. 1998 Aug 3; 17(15):4391-403. PMID: 9687507; PMCID: PMC1170772.
      174. DeFranco AL, Chan VW, Lowell CA. Positive and negative roles of the tyrosine kinase Lyn in B cell function. Semin Immunol. 1998 Aug; 10(4):299-307. PMID: 9695186.
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      175. Chan VW, Mecklenbräuker I, Su I, Texido G, Leitges M, Carsetti R, Lowell CA, Rajewsky K, Miyake K, Tarakhovsky A. The molecular mechanism of B cell activation by toll-like receptor protein RP-105. J Exp Med. 1998 Jul 6; 188(1):93-101. PMID: 9653087; PMCID: PMC2525555.
      176. Lowell CA, Berton G. Resistance to endotoxic shock and reduced neutrophil migration in mice deficient for the Src-family kinases Hck and Fgr. Proc Natl Acad Sci U S A. 1998 Jun 23; 95(13):7580-4. PMID: 9636192; PMCID: PMC22689.
      177. Chan VW, Lowell CA, DeFranco AL. Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes. Curr Biol. 1998 May 7; 8(10):545-53. PMID: 9601638.
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      178. Jadus MR, Williams CC, Avina MD, Ly M, Kim S, Liu Y, Narasaki R, Lowell CA, Wepsic HT. Macrophages kill T9 glioma tumor cells bearing the membrane isoform of macrophage colony stimulating factor through a phagocytosis-dependent pathway. J Immunol. 1998 Jan 1; 160(1):361-8. PMID: 9551992.
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      179. Schwartzberg PL, Xing L, Hoffmann O, Lowell CA, Garrett L, Boyce BF, Varmus HE. Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src-/- mutant mice. Genes Dev. 1997 Nov 1; 11(21):2835-44. PMID: 9353253; PMCID: PMC316651.
      180. Crowley MT, Costello PS, Fitzer-Attas CJ, Turner M, Meng F, Lowell C, Tybulewicz VL, DeFranco AL. A critical role for Syk in signal transduction and phagocytosis mediated by Fcgamma receptors on macrophages. J Exp Med. 1997 Oct 6; 186(7):1027-39. PMID: 9314552; PMCID: PMC2199061.
      181. Chan VW, Meng F, Soriano P, DeFranco AL, Lowell CA. Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation. Immunity. 1997 Jul; 7(1):69-81. PMID: 9252121.
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      182. Meng F, Lowell CA. Lipopolysaccharide (LPS)-induced macrophage activation and signal transduction in the absence of Src-family kinases Hck, Fgr, and Lyn. J Exp Med. 1997 May 5; 185(9):1661-70. PMID: 9151903; PMCID: PMC2196288.
      183. De Franceschi L, Fumagalli L, Olivieri O, Corrocher R, Lowell CA, Berton G. Deficiency of Src family kinases Fgr and Hck results in activation of erythrocyte K/Cl cotransport. J Clin Invest. 1997 Jan 15; 99(2):220-7. PMID: 9005990; PMCID: PMC507789.
      184. Lowell CA, Soriano P. Knockouts of Src-family kinases: stiff bones, wimpy T cells, and bad memories. Genes Dev. 1996 Aug 1; 10(15):1845-57. PMID: 8756343.
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      185. Lowell CA, Fumagalli L, Berton G. Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions. J Cell Biol. 1996 May; 133(4):895-910. PMID: 8666673; PMCID: PMC2120842.
      186. Lowell CA, Niwa M, Soriano P, Varmus HE. Deficiency of the Hck and Src tyrosine kinases results in extreme levels of extramedullary hematopoiesis. Blood. 1996 Mar 1; 87(5):1780-92. PMID: 8634424.
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      187. Berton G, Yan SR, Fumagalli L, Lowell CA. Neutrophil activation by adhesion: mechanisms and pathophysiological implications. Int J Clin Lab Res. 1996; 26(3):160-77. PMID: 8905448.
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      188. Lowell CA, Soriano P, Varmus HE. Functional overlap in the src gene family: inactivation of hck and fgr impairs natural immunity. Genes Dev. 1994 Feb 15; 8(4):387-98. PMID: 8125254.
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      189. Varmus HE, Lowell CA. Cancer genes and hematopoiesis. Blood. 1994 Jan 1; 83(1):5-9. PMID: 8274752.
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      190. Lowell CA, Klickstein LB, Carter RH, Mitchell JA, Fearon DT, Ahearn JM. Mapping of the Epstein-Barr virus and C3dg binding sites to a common domain on complement receptor type 2. J Exp Med. 1989 Dec 1; 170(6):1931-46. PMID: 2479703; PMCID: PMC2189535.
      191. Lowell CA, Tomlinson PT, Koch KE. Sucrose-metabolizing enzymes in transport tissues and adjacent sink structures in developing citrus fruit. Plant Physiol. 1989 Aug; 90(4):1394-402. PMID: 16666942.
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      192. Shirey RS, Morton SJ, Lawton KB, Lowell C, Kickler TS, Ness PM. Fenoprofen-induced immune hemolysis. Difficulties in diagnosis and complications in compatibility testing. Am J Clin Pathol. 1988 Mar; 89(3):410-4. PMID: 3348176.
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      193. Lowell CA, Stearman RS, Morrow JF. Transcriptional regulation of serum amyloid A gene expression. J Biol Chem. 1986 Jun 25; 261(18):8453-61. PMID: 2424896.
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      194. Lowell CA, Potter DA, Stearman RS, Morrow JF. Structure of the murine serum amyloid A gene family. Gene conversion. J Biol Chem. 1986 Jun 25; 261(18):8442-52. PMID: 3013853.
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      195. Stearman RS, Lowell CA, Peltzman CG, Morrow JF. The sequence and structure of a new serum amyloid A gene. Nucleic Acids Res. 1986 Jan 24; 14(2):797-809. PMID: 3003697; PMCID: PMC339465.
      196. Stearman RS, Lowell CA, Pearson WR, Morrow JF. Regulation of synthesis of amyloid A-related protein. Ann N Y Acad Sci. 1982; 389:106-15. PMID: 6953913.
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      197. Bogenhagen D, Lowell C, Clayton DA. Mechanism of mitochondrial DNA replication in mouse L-cells. Replication of unicircular dimer molecules. J Mol Biol. 1981 May 5; 148(1):77-93. PMID: 7310869.
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      198. Lowell C, Bogenhagen D, Clayton DA. S1 nuclease-specific nicking of mitochondrial DNA containing displacement loops. Anal Biochem. 1978 Dec; 91(2):521-31. PMID: 9762139.
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      199. Howitt JW, Lowell C. Topical anesthetic effectiveness. An old and new product evaluated. N Y J Dent. 1972 Nov; 38(9):549-50. PMID: 4562117.
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      200. Howitt JW, Lowell C. Topical anesthetic effectiveness. An old and new product evaluated. N Y State Dent J. 1972 Nov; 38(9):549-50. PMID: 4578243.
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