Cory Nicholas, PhD
|School||UCSF School of Medicine|
|Address||35 Medical Center way|
San Fancisco CA 94143
We are investigating the molecular mechanisms that regulate human cortical interneuron development, pathophysiology, and regeneration, utilizing both primary fetal and pluripotent stem cell systems. Several intractable neuro-developmental, -psychiatric, and –degenerative disorders have been linked, at least in part, to deficiencies in cortical interneurons and consequent imbalances in neuronal excitation and inhibition. Our goals are to understand how interneuron dysfunction contributes to the initiation and progression of neurological disorders and to develop effective interneuron-based treatments for patients with epilepsy, neuropathic pain, autism, schizophrenia, Parkinson's, Huntington's, and Alzheimer's disease.
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