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    Cory Nicholas, PhD

    TitleAssistant Professor
    SchoolUCSF School of Medicine
    DepartmentNeurology
    Address35 Medical Center way
    San Fancisco CA 94143
    Phone415-476-0878

       Biography 
       Education and Training
      University of California, San FranciscoPh.D. Graduate Division (Biomedical Sciences)2009

       Overview 
       Overview
      We are investigating the molecular mechanisms that regulate human cortical interneuron development, pathophysiology, and regeneration, utilizing both primary fetal and pluripotent stem cell systems. Several intractable neuro-developmental, -psychiatric, and –degenerative disorders have been linked, at least in part, to deficiencies in cortical interneurons and consequent imbalances in neuronal excitation and inhibition. Our goals are to understand how interneuron dysfunction contributes to the initiation and progression of neurological disorders and to develop effective interneuron-based treatments for patients with epilepsy, neuropathic pain, autism, schizophrenia, Parkinson's, Huntington's, and Alzheimer's disease.


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       Bibliographic 
       Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Southwell DG, Nicholas CR, Basbaum AI, Stryker MP, Kriegstein AR, Rubenstein JL, Alvarez-Buylla A. Interneurons from embryonic development to cell-based therapy. Science. 2014 Apr 11; 344(6180):1240622.
        View in: PubMed
      2. Nicholas CR, Chen J, Tang Y, Southwell DG, Chalmers N, Vogt D, Arnold CM, Chen YJ, Stanley EG, Elefanty AG, Sasai Y, Alvarez-Buylla A, Rubenstein JL, Kriegstein AR. Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development. Cell Stem Cell. 2013 May 2; 12(5):573-86.
        View in: PubMed
      3. Chen YJ, Vogt D, Wang Y, Visel A, Silberberg SN, Nicholas CR, Danjo T, Pollack JL, Pennacchio LA, Anderson S, Sasai Y, Baraban SC, Kriegstein AR, Alvarez-Buylla A, Rubenstein JL. Use of "MGE enhancers" for labeling and selection of embryonic stem cell-derived medial ganglionic eminence (MGE) progenitors and neurons. PLoS One. 2013; 8(5):e61956.
        View in: PubMed
      4. Nicholas CR, Kriegstein AR. Regenerative medicine: Cell reprogramming gets direct. Nature. 2010 Feb 25; 463(7284):1031-2.
        View in: PubMed
      5. Nicholas CR, Haston KM, Pera RA. Intact fetal ovarian cord formation promotes mouse oocyte survival and development. BMC Dev Biol. 2010; 10:2.
        View in: PubMed
      6. Nicholas CR, Haston KM, Grewall AK, Longacre TA, Reijo Pera RA. Transplantation directs oocyte maturation from embryonic stem cells and provides a therapeutic strategy for female infertility. Hum Mol Genet. 2009 Nov 15; 18(22):4376-89.
        View in: PubMed
      7. Nicholas CR, Chavez SL, Baker VL, Reijo Pera RA. Instructing an embryonic stem cell-derived oocyte fate: lessons from endogenous oogenesis. Endocr Rev. 2009 May; 30(3):264-83.
        View in: PubMed
      8. Nicholas CR, Xu EY, Banani SF, Hammer RE, Hamra FK, Reijo Pera RA. Characterization of a Dazl-GFP germ cell-specific reporter. Genesis. 2009 Feb; 47(2):74-84.
        View in: PubMed
      9. Kossack N, Meneses J, Shefi S, Nguyen HN, Chavez S, Nicholas C, Gromoll J, Turek PJ, Reijo-Pera RA. Isolation and characterization of pluripotent human spermatogonial stem cell-derived cells. Stem Cells. 2009 Jan; 27(1):138-49.
        View in: PubMed
      10. Nicholas CR, Reijo Pera RA. Method for single-cell sorting and expansion of genetically modified human embryonic stem cells. CSH Protoc. 2008; 2008:pdb.prot5045.
        View in: PubMed
      11. Nicholas CR, Gaur M, Wang S, Pera RA, Leavitt AD. A method for single-cell sorting and expansion of genetically modified human embryonic stem cells. Stem Cells Dev. 2007 Feb; 16(1):109-17.
        View in: PubMed
      12. O'Shea CC, Johnson L, Bagus B, Choi S, Nicholas C, Shen A, Boyle L, Pandey K, Soria C, Kunich J, Shen Y, Habets G, Ginzinger D, McCormick F. Late viral RNA export, rather than p53 inactivation, determines ONYX-015 tumor selectivity. Cancer Cell. 2004 Dec; 6(6):611-23.
        View in: PubMed
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