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    Dai Horiuchi, PhD

    TitleAsst Professional Researcher
    SchoolUCSF School of Dentistry
    DepartmentCell and Tissue Biology
    Address513 Parnassus Ave
    San Francisco CA 94143

       Education and Training
      University of California, San FranciscoPostdoctoral StudiesGraduate Division
       Awards and Honors
      National Institute of Health/National Cancer Institute2013 - 2018K99/R00 Pathway to Independence Award (1K99CA175700-01)
      California Breast Cancer Research Program2011 - 2012Innovative, Developmental, and Exploratory Award (IDEA) (17IB-0024), with Andrei Goga, M.D., Ph.D.
      California Breast Cancer Research Program2009 - 2011Post-doctoral Fellowship Award (15FB-0006)
      American Heart Association2006Pre-doctoral Fellowship Award (0610055Z)
      American Heart Association2004 - 2005Pre-doctoral Fellowship Award (0410070Z)

      *I will be starting my lab at Northwestern University Feinberg School of Medicine in Chicago in April 2015. My affiliation will be with the Department of Pharmacology and Robert H. Lurie Comprehensive Cancer Center.
      My primary research interest is in understanding (1) the mechanisms of tumor maintenance and (2) how to induce apoptosis selectively in tumors driven by the complex oncogenic networks by taking advantage of a wide range of experimental model systems with my particular interest in breast cancers. My research projects combine cell-based loss-of-function/gain-of-function screens, cell biological and bioinformatics approaches, combined with animal models to identify novel treatment strategies and test them in early stage clinical studies.

      Primary mentor: Andrei Goga, M.D., Ph.D.
      Co-mentor: J. Michael Bishop, M.D.

      Associate Member, UCSF Helen Diller Family Comprehensive Cancer Center
      Associate Member, American Association for Cancer Research (AACR)
      Postdoctoral Member, American Association for the Advancement of Science (AAAS)
      Founding Member, Science Policy Group at UCSF

       ORNG Applications 
       In The News

      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Martins MM, Zhou AY, Corella A, Horiuchi D, Yau C, Rakshandehroo T, Gordan JD, Levin RS, Johnson J, Jascur J, Shales M, Sorrentino A, Cheah J, Clemons PA, Shamji AF, Schreiber SL, Krogan NJ, Shokat KM, McCormick F, Goga A, Bandyopadhyay S. Linking Tumor Mutations to Drug Responses via a Quantitative Chemical-Genetic Interaction Map. Cancer Discov. 2015 Feb; 5(2):154-67.
        View in: PubMed
      2. Horiuchi D, Anderton B, Goga A. Taking on challenging targets: making MYC druggable. Am Soc Clin Oncol Educ Book. 2014; e497-502.
        View in: PubMed
      3. Balko JM, Giltnane JM, Wang K, Schwarz LJ, Young CD, Cook RS, Owens P, Sanders ME, Kuba MG, Sánchez V, Kurupi R, Moore PD, Pinto JA, Doimi FD, Gómez H, Horiuchi D, Goga A, Lehmann BD, Bauer JA, Pietenpol JA, Ross JS, Palmer GA, Yelensky R, Cronin M, Miller VA, Stephens PJ, Arteaga CL. Molecular profiling of the residual disease of triple-negative breast cancers after neoadjuvant chemotherapy identifies actionable therapeutic targets. Cancer Discov. 2014 Feb; 4(2):232-45.
        View in: PubMed PMC3946308
      4. Horiuchi D, Huskey NE, Kusdra L, Wohlbold L, Merrick KA, Zhang C, Creasman KJ, Shokat KM, Fisher RP, Goga A. Chemical-genetic analysis of cyclin dependent kinase 2 function reveals an important role in cellular transformation by multiple oncogenic pathways. Proc Natl Acad Sci U S A. 2012 Apr 24; 109(17):E1019-27.
        View in: PubMed PMC3340028
      5. Horiuchi D, Kusdra L, Huskey NE, Chandriani S, Lenburg ME, Gonzalez-Angulo AM, Creasman KJ, Bazarov AV, Smyth JW, Davis SE, Yaswen P, Mills GB, Esserman LJ, Goga A. MYC pathway activation in triple-negative breast cancer is synthetic lethal with CDK inhibition. J Exp Med. 2012 Apr 9; 209(4):679-96.
        View in: PubMed PMC3328367
      6. Merrick KA, Wohlbold L, Zhang C, Allen JJ, Horiuchi D, Huskey NE, Goga A, Shokat KM, Fisher RP. Switching Cdk2 on or off with small molecules to reveal requirements in human cell proliferation. Mol Cell. 2011 Jun 10; 42(5):624-36.
        View in: PubMed PMC3119039
      7. Huang TH, Wu F, Loeb GB, Hsu R, Heidersbach A, Brincat A, Horiuchi D, Lebbink RJ, Mo YY, Goga A, McManus MT. Up-regulation of miR-21 by HER2/neu signaling promotes cell invasion. J Biol Chem. 2009 Jul 3; 284(27):18515-24.
        View in: PubMed PMC2709372
      8. Barkus RV, Klyachko O, Horiuchi D, Dickson BJ, Saxton WM. Identification of an axonal kinesin-3 motor for fast anterograde vesicle transport that facilitates retrograde transport of neuropeptides. Mol Biol Cell. 2008 Jan; 19(1):274-83.
        View in: PubMed PMC2174192
      9. Horiuchi D, Collins CA, Bhat P, Barkus RV, Diantonio A, Saxton WM. Control of a kinesin-cargo linkage mechanism by JNK pathway kinases. Curr Biol. 2007 Aug 7; 17(15):1313-7.
        View in: PubMed PMC2041807
      10. Pilling AD, Horiuchi D, Lively CM, Saxton WM. Kinesin-1 and Dynein are the primary motors for fast transport of mitochondria in Drosophila motor axons. Mol Biol Cell. 2006 Apr; 17(4):2057-68.
        View in: PubMed PMC1415296
      11. Horiuchi D, Barkus RV, Pilling AD, Gassman A, Saxton WM. APLIP1, a kinesin binding JIP-1/JNK scaffold protein, influences the axonal transport of both vesicles and mitochondria in Drosophila. Curr Biol. 2005 Dec 6; 15(23):2137-41.
        View in: PubMed PMC1532932
      12. Sato K, Kimoto M, Kakumoto M, Horiuchi D, Iwasaki T, Tokmakov AA, Fukami Y. Adaptor protein Shc undergoes translocation and mediates up-regulation of the tyrosine kinase c-Src in EGF-stimulated A431 cells. Genes Cells. 2000 Sep; 5(9):749-64.
        View in: PubMed
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