David Agard, PhD

Title(s)Professor, Biochemistry and Biophysics
SchoolSchool of Medicine
Address600 16th St, #S412D
San Francisco CA 94158
Phone415-476-5143
vCardDownload vCard
    Other Positions
    Title(s)Howard Hughes Investigator


    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPostdoctoral StudiesGraduate Division - Biochemistry

    Collapse Research 
    Collapse Research Activities and Funding
    Tau Metabolism in FTD: From Gene Mutations to Molecular Chaperones and Lysosomal Proteases
    NIH U54NS123985Sep 27, 2021 - Aug 31, 2026
    Role: Co-Principal Investigator
    Structure and Mechanism: Hsp90 proteostasis, cilia biogenesis and the jumbo phage ?nucleus?
    NIH R35GM118099Jun 1, 2016 - May 31, 2026
    Role: Principal Investigator
    The Yeast Centrosome - Structure Assembly & Function
    NIH P01GM105537Sep 1, 2014 - Aug 31, 2020
    Role: Co-Investigator
    Characterization of a bacteriophage tubulin involved in viral replication
    NIH R01GM104556Aug 1, 2013 - Apr 30, 2018
    Role: Principal Investigator
    Structural Basis of Protein Homeostasis
    NIH U01GM098254Sep 30, 2012 - Jul 31, 2016
    Role: Principal Investigator
    National Resource for Automated Molecular Microscopy
    NIH P41RR017573Sep 30, 2002 - Jul 31, 2012
    Role: Co-Investigator
    STRUCTURE AND DYNAMICS OF NUCLEAR RECEPTORS
    NIH P01DK058390Aug 15, 2000 - Jul 31, 2006
    Role: Co-Investigator
    FASEB CONFERENCE: PROTEIN FOLDING AND ASSEMBLY IN CELLS
    NIH R13GM061717Jul 1, 2000 - Jun 30, 2001
    Role: Principal Investigator
    GATAN IMAGING ENERGY FILTER WITH CCD CAMERA FOR IVEM
    NIH S10RR013926Feb 1, 2000 - Jan 31, 2001
    Role: Principal Investigator
    Comprehensive Biology: Exploiting the Yeast Genome
    NIH P41RR011823Sep 30, 1996 - Jun 30, 2016
    Role: Co-Investigator
    BioCAT - Biophysics Collaborative Access Team
    NIH P41RR008630Sep 30, 1995 - Mar 31, 2012
    Role: Co-Investigator
    Molecular Biophysics Training Grant
    NIH T32GM008284Sep 30, 1988 - Jun 30, 2023
    Role: Principal Investigator
    National Biomedical NMR Resource at Madison
    NIH P41RR002301Jul 1, 1985 - Feb 28, 2015
    Role: Co-Investigator
    Macromolecular Diffraction Resource: MacCHESS
    NIH P41RR001646Sep 1, 1983 - Jun 30, 2013
    Role: Co-Investigator
    Centrosome structure and mechanism of MT nucleation by gamma-tubulin complexes
    NIH R01GM031627Mar 1, 1983 - Dec 31, 2016
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator
    A Synchroton Radiation Structural Biology Resource
    NIH P41RR001209Mar 1, 1980 - Feb 28, 2015
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Academic Senate

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Functionalized graphene-oxide grids enable high-resolution cryo-EM structures of the SNF2h-nucleosome complex without crosslinking. Nat Commun. 2024 Mar 12; 15(1):2225. Chio US, Palovcak E, Smith AAA, Autzen H, Muñoz EN, Yu Z, Wang F, Agard DA, Armache JP, Narlikar GJ, Cheng Y. PMID: 38472177; PMCID: PMC10933330.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    2. Poc1 is a basal body inner junction protein that promotes triplet microtubule integrity and interconnections. bioRxiv. 2023 Nov 28. Ruehle MD, Li S, Agard DA, Pearson CG. PMID: 38014135; PMCID: PMC10680851.
      View in: PubMed   Mentions:
    3. Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the glucocorticoid receptor. Nat Struct Mol Biol. 2023 Dec; 30(12):1867-1877. Noddings CM, Johnson JL, Agard DA. PMID: 37945740; PMCID: PMC10716051.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    4. The next decade in structural biology. Structure. 2023 11 02; 31(11):1284-1288. Walsh MA, Nannenga BL, Gonen T, Sexton PM, Wootten D, Chiu W, Sun F, Carragher B, Potter CS, Agard D, Burley SK. PMID: 37922863.
      View in: PubMed   Mentions:    Fields:    
    5. De novo protein identification in mammalian sperm using in situ cryoelectron tomography and AlphaFold2 docking. Cell. 2023 11 09; 186(23):5041-5053.e19. Chen Z, Shiozaki M, Haas KM, Skinner WM, Zhao S, Guo C, Polacco BJ, Yu Z, Krogan NJ, Lishko PV, Kaake RM, Vale RD, Agard DA. PMID: 37865089; PMCID: PMC10842264.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    6. Next-generation proteomics for quantitative Jumbophage-bacteria interaction mapping. Nat Commun. 2023 08 24; 14(1):5156. Fossati A, Mozumdar D, Kokontis C, Mèndez-Moran M, Nieweglowska E, Pelin A, Li Y, Guo B, Krogan NJ, Agard DA, Bondy-Denomy J, Swaney DL. PMID: 37620325; PMCID: PMC10449902.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    7. Functionalized graphene-oxide grids enable high-resolution cryo-EM structures of the SNF2h-nucleosome complex without crosslinking. bioRxiv. 2023 Jun 20. Chio US, Palovcak E, Autzen AAA, Autzen HE, Muñoz EN, Yu Z, Wang F, Agard DA, Armache JP, Narlikar GJ, Cheng Y. PMID: 37546986; PMCID: PMC10402172.
      View in: PubMed   Mentions:
    8. Hsp90 provides a platform for kinase dephosphorylation by PP5. Nat Commun. 2023 04 17; 14(1):2197. Jaime-Garza M, Nowotny CA, Coutandin D, Wang F, Tabios M, Agard DA. PMID: 37069154; PMCID: PMC10110553.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    9. Next-generation interaction proteomics for quantitative Jumbophage-bacteria interaction mapping. bioRxiv. 2023 Feb 23. Fossati A, Mozumdar D, Kokontis C, Mèndez-Moran M, Nieweglowska E, Pelin A, Li Y, Guo B, Krogan NJ, Agard DA, Bondy-Denomy J, Swaney DL. PMID: 36711836; PMCID: PMC9882154.
      View in: PubMed   Mentions:
    10. The ϕPA3 phage nucleus is enclosed by a self-assembling 2D crystalline lattice. Nat Commun. 2023 02 18; 14(1):927. Nieweglowska ES, Brilot AF, Méndez-Moran M, Kokontis C, Baek M, Li J, Cheng Y, Baker D, Bondy-Denomy J, Agard DA. PMID: 36807264; PMCID: PMC9938867.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    11. Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the Glucocorticoid Receptor. bioRxiv. 2023 Jan 16. Noddings CM, Johnson JL, Agard DA. PMID: 36711821; PMCID: PMC9882067.
      View in: PubMed   Mentions:
    12. Improved Analysis of Cross-Linking Mass Spectrometry Data with Kojak 2.0, Advanced by Integration into the Trans-Proteomic Pipeline. J Proteome Res. 2023 02 03; 22(2):647-655. Hoopmann MR, Shteynberg DD, Zelter A, Riffle M, Lyon AS, Agard DA, Luan Q, Nolen BJ, MacCoss MJ, Davis TN, Moritz RL. PMID: 36629399; PMCID: PMC10234491.
      View in: PubMed   Mentions:    Fields:    
    13. In situ cryo-electron tomography reveals the asymmetric architecture of mammalian sperm axonemes. Nat Struct Mol Biol. 2023 03; 30(3):360-369. Chen Z, Greenan GA, Shiozaki M, Liu Y, Skinner WM, Zhao X, Zhao S, Yan R, Yu Z, Lishko PV, Agard DA, Vale RD. PMID: 36593309; PMCID: PMC10023559.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    14. Solution of the protein structure prediction problem at last: crucial innovations and next frontiers. Fac Rev. 2022; 11:38. Agard DA, Bowman GR, DeGrado W, Dokholyan NV, Zhou HX. PMID: 36644294; PMCID: PMC9815721.
      View in: PubMed   Mentions:
    15. Interactions between mTORC2 core subunits Rictor and mSin1 dictate selective and context-dependent phosphorylation of substrate kinases SGK1 and Akt. J Biol Chem. 2022 09; 298(9):102288. Yu Z, Chen J, Takagi E, Wang F, Saha B, Liu X, Joubert LM, Gleason CE, Jin M, Li C, Nowotny C, Agard D, Cheng Y, Pearce D. PMID: 35926713; PMCID: PMC9440446.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    16. AreTomo: An integrated software package for automated marker-free, motion-corrected cryo-electron tomographic alignment and reconstruction. J Struct Biol X. 2022; 6:100068. Zheng S, Wolff G, Greenan G, Chen Z, Faas FGA, Bárcena M, Koster AJ, Cheng Y, Agard DA. PMID: 35601683; PMCID: PMC9117686.
      View in: PubMed   Mentions: 36  
    17. Author Correction: Structures of the HER2-HER3-NRG1β complex reveal a dynamic dimer interface. Nature. 2022 Feb; 602(7898):E26. Diwanji D, Trenker R, Thaker TM, Wang F, Agard DA, Verba KA, Jura N. PMID: 35132240.
      View in: PubMed   Mentions:    Fields:    
    18. Electron cryo-tomography structure of axonemal doublet microtubule from Tetrahymena thermophila. Life Sci Alliance. 2022 03; 5(3). Li S, Fernandez JJ, Fabritius AS, Agard DA, Winey M. PMID: 34969817; PMCID: PMC8742875.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    19. Structure of Hsp90-p23-GR reveals the Hsp90 client-remodelling mechanism. Nature. 2022 01; 601(7893):465-469. Noddings CM, Wang RY, Johnson JL, Agard DA. PMID: 34937936; PMCID: PMC8994517.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    20. Structure of Hsp90-Hsp70-Hop-GR reveals the Hsp90 client-loading mechanism. Nature. 2022 01; 601(7893):460-464. Wang RY, Noddings CM, Kirschke E, Myasnikov AG, Johnson JL, Agard DA. PMID: 34937942; PMCID: PMC9179170.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    21. Entropy-regularized deconvolution of cellular cryotransmission electron tomograms. Proc Natl Acad Sci U S A. 2021 12 14; 118(50). Croxford M, Elbaum M, Arigovindan M, Kam Z, Agard D, Villa E, Sedat J. PMID: 34876518; PMCID: PMC8685678.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    22. Structures of the HER2-HER3-NRG1β complex reveal a dynamic dimer interface. Nature. 2021 12; 600(7888):339-343. Diwanji D, Trenker R, Thaker TM, Wang F, Agard DA, Verba KA, Jura N. PMID: 34759323; PMCID: PMC9298180.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    23. Proteomic analysis of microtubule inner proteins (MIPs) in Rib72 null Tetrahymena cells reveals functional MIPs. Mol Biol Cell. 2021 11 01; 32(21):br8. Fabritius AS, Bayless BA, Li S, Stoddard D, Heydeck W, Ebmeier CC, Anderson L, Gunnels T, Nachiappan C, Whittall JB, Old W, Agard DA, Nicastro D, Winey M. PMID: 34406789; PMCID: PMC8693976.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    24. CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes. Res Sq. 2021 May 19. Gupta M, Azumaya CM, Moritz M, Pourmal S, Diallo A, Merz GE, Jang G, Bouhaddou M, Fossati A, Brilot AF, Diwanji D, Hernandez E, Herrera N, Kratochvil HT, Lam VL, Li F, Li Y, Nguyen HC, Nowotny C, Owens TW, Peters JK, Rizo AN, Schulze-Gahmen U, Smith AM, Young ID, Yu Z, Asarnow D, Billesbølle C, Campbell MG, Chen J, Chen KH, Chio US, Dickinson MS, Doan L, Jin M, Kim K, Li J, Li YL, Linossi E, Liu Y, Lo M, Lopez J, Lopez KE, Mancino A, Moss FR, Paul MD, Pawar KI, Pelin A, Pospiech TH, Puchades C, Remesh SG, Safari M, Schaefer K, Sun M, Tabios MC, Thwin AC, Titus EW, Trenker R, Tse E, Tsui TKM, Wang F, Zhang K, Zhang Y, Zhao J, Zhou F, Zhou Y, Zuliani-Alvarez L, QCRG Structural Biology Consortium, Agard DA, Cheng Y, Fraser JS, Jura N, Kortemme T, Manglik A, Southworth DR, Stroud RM, Swaney DL, Krogan NJ, Frost A, Rosenberg OS, Verba KA. PMID: 34031651; PMCID: PMC8142659.
      View in: PubMed   Mentions: 1  
    25. Practical considerations for using K3 cameras in CDS mode for high-resolution and high-throughput single particle cryo-EM. J Struct Biol. 2021 09; 213(3):107745. Sun M, Azumaya CM, Tse E, Bulkley DP, Harrington MB, Gilbert G, Frost A, Southworth D, Verba KA, Cheng Y, Agard DA. PMID: 33984504.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    26. CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes. bioRxiv. 2021 May 11. Gupta M, Azumaya CM, Moritz M, Pourmal S, Diallo A, Merz GE, Jang G, Bouhaddou M, Fossati A, Brilot AF, Diwanji D, Hernandez E, Herrera N, Kratochvil HT, Lam VL, Li F, Li Y, Nguyen HC, Nowotny C, Owens TW, Peters JK, Rizo AN, Schulze-Gahmen U, Smith AM, Young ID, Yu Z, Asarnow D, Billesbølle C, Campbell MG, Chen J, Chen KH, Chio US, Dickinson MS, Doan L, Jin M, Kim K, Li J, Li YL, Linossi E, Liu Y, Lo M, Lopez J, Lopez KE, Mancino A, Moss FR, Paul MD, Pawar KI, Pelin A, Pospiech TH, Puchades C, Remesh SG, Safari M, Schaefer K, Sun M, Tabios MC, Thwin AC, Titus EW, Trenker R, Tse E, Tsui TKM, Wang F, Zhang K, Zhang Y, Zhao J, Zhou F, Zhou Y, Zuliani-Alvarez L, QCRG Structural Biology Consortium, Agard DA, Cheng Y, Fraser JS, Jura N, Kortemme T, Manglik A, Southworth DR, Stroud RM, Swaney DL, Krogan NJ, Frost A, Rosenberg OS, Verba KA. PMID: 34013269; PMCID: PMC8132225.
      View in: PubMed   Mentions: 3  
    27. CM1-driven assembly and activation of yeast γ-tubulin small complex underlies microtubule nucleation. Elife. 2021 05 05; 10. Brilot AF, Lyon AS, Zelter A, Viswanath S, Maxwell A, MacCoss MJ, Muller EG, Sali A, Davis TN, Agard DA. PMID: 33949948; PMCID: PMC8099430.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    28. Microtubules form by progressively faster tubulin accretion, not by nucleation-elongation. J Cell Biol. 2021 05 03; 220(5). Rice LM, Moritz M, Agard DA. PMID: 33734292; PMCID: PMC7980253.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    29. Hsp70 chaperone blocks α-synuclein oligomer formation via a novel engagement mechanism. J Biol Chem. 2021 Jan-Jun; 296:100613. Tao J, Berthet A, Citron YR, Tsiolaki PL, Stanley R, Gestwicki JE, Agard DA, McConlogue L. PMID: 33798554; PMCID: PMC8102405.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    30. [The basics of immobilisation]. Rev Infirm. 2021 Jan; 70(267):28-30. Rebours I, Agard D, Messager C, Cattelin C, Barbier O, Choufani C. PMID: 33455677.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    31. Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. Science. 2020 12 04; 370(6521). Gordon DE, Hiatt J, Bouhaddou M, Rezelj VV, Ulferts S, Braberg H, Jureka AS, Obernier K, Guo JZ, Batra J, Kaake RM, Weckstein AR, Owens TW, Gupta M, Pourmal S, Titus EW, Cakir M, Soucheray M, McGregor M, Cakir Z, Jang G, O'Meara MJ, Tummino TA, Zhang Z, Foussard H, Rojc A, Zhou Y, Kuchenov D, Hüttenhain R, Xu J, Eckhardt M, Swaney DL, Fabius JM, Ummadi M, Tutuncuoglu B, Rathore U, Modak M, Haas P, Haas KM, Naing ZZC, Pulido EH, Shi Y, Barrio-Hernandez I, Memon D, Petsalaki E, Dunham A, Marrero MC, Burke D, Koh C, Vallet T, Silvas JA, Azumaya CM, Billesbølle C, Brilot AF, Campbell MG, Diallo A, Dickinson MS, Diwanji D, Herrera N, Hoppe N, Kratochvil HT, Liu Y, Merz GE, Moritz M, Nguyen HC, Nowotny C, Puchades C, Rizo AN, Schulze-Gahmen U, Smith AM, Sun M, Young ID, Zhao J, Asarnow D, Biel J, Bowen A, Braxton JR, Chen J, Chio CM, Chio US, Deshpande I, Doan L, Faust B, Flores S, Jin M, Kim K, Lam VL, Li F, Li J, Li YL, Li Y, Liu X, Lo M, Lopez KE, Melo AA, Moss FR, Nguyen P, Paulino J, Pawar KI, Peters JK, Pospiech TH, Safari M, Sangwan S, Schaefer K, Thomas PV, Thwin AC, Trenker R, Tse E, Tsui TKM, Wang F, Whitis N, Yu Z, Zhang K, Zhang Y, Zhou F, Saltzberg D, QCRG Structural Biology Consortium, Hodder AJ, Shun-Shion AS, Williams DM, White KM, Rosales R, Kehrer T, Miorin L, Moreno E, Patel AH, Rihn S, Khalid MM, Vallejo-Gracia A, Fozouni P, Simoneau CR, Roth TL, Wu D, Karim MA, Ghoussaini M, Dunham I, Berardi F, Weigang S, Chazal M, Park J, Logue J, McGrath M, Weston S, Haupt R, Hastie CJ, Elliott M, Brown F, Burness KA, Reid E, Dorward M, Johnson C, Wilkinson SG, Geyer A, Giesel DM, Baillie C, Raggett S, Leech H, Toth R, Goodman N, Keough KC, Lind AL, Zoonomia Consortium, Klesh RJ, Hemphill KR, Carlson-Stevermer J, Oki J, Holden K, Maures T, Pollard KS, Sali A, Agard DA, Cheng Y, Fraser JS, Frost A, Jura N, Kortemme T, Manglik A, Southworth DR, Stroud RM, Alessi DR, Davies P, Frieman MB, Ideker T, Abate C, Jouvenet N, Kochs G, Shoichet B, et al. PMID: 33060197; PMCID: PMC7808408.
      View in: PubMed   Mentions: 338     Fields:    Translation:HumansCells
    32. General and robust covalently linked graphene oxide affinity grids for high-resolution cryo-EM. Proc Natl Acad Sci U S A. 2020 09 29; 117(39):24269-24273. Wang F, Liu Y, Yu Z, Li S, Feng S, Cheng Y, Agard DA. PMID: 32913054; PMCID: PMC7533693.
      View in: PubMed   Mentions: 30     Fields:    
    33. A molecular pore spans the double membrane of the coronavirus replication organelle. Science. 2020 09 11; 369(6509):1395-1398. Wolff G, Limpens RWAL, Zevenhoven-Dobbe JC, Laugks U, Zheng S, de Jong AWM, Koning RI, Agard DA, Grünewald K, Koster AJ, Snijder EJ, Bárcena M. PMID: 32763915; PMCID: PMC7665310.
      View in: PubMed   Mentions: 227     Fields:    Translation:AnimalsCells
    34. XMAP215 and γ-tubulin additively promote microtubule nucleation in purified solutions. Mol Biol Cell. 2020 09 15; 31(20):2187-2194. King BR, Moritz M, Kim H, Agard DA, Asbury CL, Davis TN. PMID: 32726183; PMCID: PMC7550701.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    35. A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature. 2020 07; 583(7816):459-468. Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Hüttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Meyer B, Roesch F, Vallet T, Mac Kain A, Miorin L, Moreno E, Naing ZZC, Zhou Y, Peng S, Shi Y, Zhang Z, Shen W, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Lyu J, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Rakesh R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Liboy-Lugo J, Lin Y, Huang XP, Liu Y, Wankowicz SA, Bohn M, Safari M, Ugur FS, Koh C, Savar NS, Tran QD, Shengjuler D, Fletcher SJ, O'Neal MC, Cai Y, Chang JCJ, Broadhurst DJ, Klippsten S, Sharp PP, Wenzell NA, Kuzuoglu-Ozturk D, Wang HY, Trenker R, Young JM, Cavero DA, Hiatt J, Roth TL, Rathore U, Subramanian A, Noack J, Hubert M, Stroud RM, Frankel AD, Rosenberg OS, Verba KA, Agard DA, Ott M, Emerman M, Jura N, von Zastrow M, Verdin E, Ashworth A, Schwartz O, d'Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Craik CS, Floor SN, Fraser JS, Gross JD, Sali A, Roth BL, Ruggero D, Taunton J, Kortemme T, Beltrao P, Vignuzzi M, García-Sastre A, Shokat KM, Shoichet BK, Krogan NJ. PMID: 32353859; PMCID: PMC7431030.
      View in: PubMed   Mentions: 2284     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    36. Author Correction: Sas-4 provides a scaffold for cytoplasmic complexes and tethers them in a centrosome. Nat Commun. 2020 Apr 15; 11(1):1862. Gopalakrishnan J, Mennella V, Blachon S, Zhai B, Smith AH, Megraw TL, Nicastro D, Gygi SP, Agard DA, Avidor-Reiss T. PMID: 32296038; PMCID: PMC7160143.
      View in: PubMed   Mentions: 1     Fields:    
    37. A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing. bioRxiv. 2020 Mar 22. Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, O'Meara MJ, Guo JZ, Swaney DL, Tummino TA, Hüttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Naing ZZC, Zhou Y, Peng S, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Shen W, Shi Y, Zhang Z, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Ramachandran R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Lin Y, Wankowicz SA, Bohn M, Trenker R, Young JM, Cavero D, Hiatt J, Roth T, Rathore U, Subramanian A, Noack J, Hubert M, Roesch F, Vallet T, Meyer B, White KM, Miorin L, Agard D, Emerman M, Ruggero D, García-Sastre A, Jura N, von Zastrow M, Taunton J, Schwartz O, Vignuzzi M, d'Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Craik CS, Floor S, Fraser JS, Gross J, Sali A, Kortemme T, Beltrao P, Shokat K, Shoichet BK, Krogan NJ. PMID: 32511329; PMCID: PMC7239059.
      View in: PubMed   Mentions: 28  
    38. The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in mitochondrial metabolic homeostasis. BMC Biol. 2020 01 27; 18(1):10. Joshi A, Dai L, Liu Y, Lee J, Ghahhari NM, Segala G, Beebe K, Jenkins LM, Lyons GC, Bernasconi L, Tsai FTF, Agard DA, Neckers L, Picard D. PMID: 31987035; PMCID: PMC6986101.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    39. Electron cryotomography of intact motile cilia defines the basal body to axoneme transition. J Cell Biol. 2020 01 06; 219(1). Greenan GA, Vale RD, Agard DA. PMID: 31874113; PMCID: PMC7039205.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    40. Amino and PEG-amino graphene oxide grids enrich and protect samples for high-resolution single particle cryo-electron microscopy. J Struct Biol. 2020 02 01; 209(2):107437. Wang F, Yu Z, Betegon M, Campbell MG, Aksel T, Zhao J, Li S, Douglas SM, Cheng Y, Agard DA. PMID: 31866389; PMCID: PMC7272056.
      View in: PubMed   Mentions: 24     Fields:    
    41. A bacteriophage nucleus-like compartment shields DNA from CRISPR nucleases. Nature. 2020 01; 577(7789):244-248. Mendoza SD, Nieweglowska ES, Govindarajan S, Leon LM, Berry JD, Tiwari A, Chaikeeratisak V, Pogliano J, Agard DA, Bondy-Denomy J. PMID: 31819262; PMCID: PMC6949375.
      View in: PubMed   Mentions: 75     Fields:    Translation:Cells
    42. Novel Small Molecules Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein Protect Against Diverse α-Synuclein Mediated Dysfunctions. Sci Rep. 2019 11 18; 9(1):16947. Tóth G, Neumann T, Berthet A, Masliah E, Spencer B, Tao J, Jobling MF, Gardai SJ, Bertoncini CW, Cremades N, Bova M, Ballaron S, Chen XH, Mao W, Nguyen P, Tabios MC, Tambe MA, Rochet JC, Junker HD, Schwizer D, Sekul R, Ott I, Anderson JP, Szoke B, Hoffman W, Christodoulou J, Yednock T, Agard DA, Schenk D, McConlogue L. PMID: 31740740; PMCID: PMC6861283.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    43. Mind the gap: Micro-expansion joints drastically decrease the bending of FIB-milled cryo-lamellae. J Struct Biol. 2019 12 01; 208(3):107389. Wolff G, Limpens RWAL, Zheng S, Snijder EJ, Agard DA, Koster AJ, Bárcena M. PMID: 31536774.
      View in: PubMed   Mentions: 36     Fields:    Translation:Animals
    44. Viral Capsid Trafficking along Treadmilling Tubulin Filaments in Bacteria. Cell. 2019 06 13; 177(7):1771-1780.e12. Chaikeeratisak V, Khanna K, Nguyen KT, Sugie J, Egan ME, Erb ML, Vavilina A, Nonejuie P, Nieweglowska E, Pogliano K, Agard DA, Villa E, Pogliano J. PMID: 31199917; PMCID: PMC7301877.
      View in: PubMed   Mentions: 32     Fields:    Translation:Cells
    45. Electron cryo-tomography provides insight into procentriole architecture and assembly mechanism. Elife. 2019 02 11; 8. Li S, Fernandez JJ, Marshall WF, Agard DA. PMID: 30741631; PMCID: PMC6384029.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    46. Consideration of sample motion in cryo-tomography based on alignment residual interpolation. J Struct Biol. 2019 03 01; 205(3):1-6. Fernandez JJ, Li S, Agard DA. PMID: 30690142; PMCID: PMC6420838.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    47. Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau. Nat Commun. 2018 11 01; 9(1):4563. Freilich R, Betegon M, Tse E, Mok SA, Julien O, Agard DA, Southworth DR, Takeuchi K, Gestwicki JE. PMID: 30385828; PMCID: PMC6212398.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    48. Insights into centriole geometry revealed by cryotomography of doublet and triplet centrioles. Elife. 2018 08 06; 7. Greenan GA, Keszthelyi B, Vale RD, Agard DA. PMID: 30080137; PMCID: PMC6110610.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    49. The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders. Cell. 2018 07 26; 174(3):505-520. Willsey AJ, Morris MT, Wang S, Willsey HR, Sun N, Teerikorpi N, Baum TB, Cagney G, Bender KJ, Desai TA, Srivastava D, Davis GW, Doudna J, Chang E, Sohal V, Lowenstein DH, Li H, Agard D, Keiser MJ, Shoichet B, von Zastrow M, Mucke L, Finkbeiner S, Gan L, Sestan N, Ward ME, Huttenhain R, Nowakowski TJ, Bellen HJ, Frank LM, Khokha MK, Lifton RP, Kampmann M, Ideker T, State MW, Krogan NJ. PMID: 30053424; PMCID: PMC6247911.
      View in: PubMed   Mentions: 60     Fields:    Translation:Humans
    50. A simple and robust procedure for preparing graphene-oxide cryo-EM grids. J Struct Biol. 2018 10; 204(1):80-84. Palovcak E, Wang F, Zheng SQ, Yu Z, Li S, Betegon M, Bulkley D, Agard DA, Cheng Y. PMID: 30017701; PMCID: PMC6119484.
      View in: PubMed   Mentions: 49     Fields:    
    51. Calcium binding to a remote site can replace magnesium as cofactor for mitochondrial Hsp90 (TRAP1) ATPase activity. J Biol Chem. 2018 08 31; 293(35):13717-13724. Elnatan D, Agard DA. PMID: 29991590; PMCID: PMC6120219.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    52. Structural basis of mitochondrial receptor binding and constriction by DRP1. Nature. 2018 06; 558(7710):401-405. Kalia R, Wang RY, Yusuf A, Thomas PV, Agard DA, Shaw JM, Frost A. PMID: 29899447; PMCID: PMC6120343.
      View in: PubMed   Mentions: 143     Fields:    Translation:HumansCells
    53. Cryo-tomography tilt-series alignment with consideration of the beam-induced sample motion. J Struct Biol. 2018 06; 202(3):200-209. Fernandez JJ, Li S, Bharat TAM, Agard DA. PMID: 29410148; PMCID: PMC5949096.
      View in: PubMed   Mentions: 24     Fields:    
    54. The Structural Asymmetry of Mitochondrial Hsp90 (Trap1) Determines Fine Tuning of Functional Dynamics. J Chem Theory Comput. 2018 Feb 13; 14(2):1033-1044. Moroni E, Agard DA, Colombo G. PMID: 29320629.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    55. The centrosomin CM2 domain is a multi-functional binding domain with distinct cell cycle roles. PLoS One. 2018; 13(1):e0190530. Citron YR, Fagerstrom CJ, Keszthelyi B, Huang B, Rusan NM, Kelly MJS, Agard DA. PMID: 29315319; PMCID: PMC5760045.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    56. Protein Expression and Purification of the Hsp90-Cdc37-Cdk4 Kinase Complex from Saccharomyces cerevisiae. Bio Protoc. 2017 Oct 05; 7(19). Verba KA, Agard DA. PMID: 29104897; PMCID: PMC5669387.
      View in: PubMed   Mentions: 1  
    57. How Hsp90 and Cdc37 Lubricate Kinase Molecular Switches. Trends Biochem Sci. 2017 10; 42(10):799-811. Verba KA, Agard DA. PMID: 28784328; PMCID: PMC5621984.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    58. Symmetry broken and rebroken during the ATP hydrolysis cycle of the mitochondrial Hsp90 TRAP1. Elife. 2017 07 25; 6. Elnatan D, Betegon M, Liu Y, Ramelot T, Kennedy MA, Agard DA. PMID: 28742020; PMCID: PMC5550277.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    59. NMR characterization of HtpG, the E. coli Hsp90, using sparse labeling with 13C-methyl alanine. J Biomol NMR. 2017 Jul; 68(3):225-236. Pederson K, Chalmers GR, Gao Q, Elnatan D, Ramelot TA, Ma LC, Montelione GT, Kennedy MA, Agard DA, Prestegard JH. PMID: 28653216; PMCID: PMC5546222.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    60. Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin. Nature. 2017 07 13; 547(7662):236-240. Larson AG, Elnatan D, Keenen MM, Trnka MJ, Johnston JB, Burlingame AL, Agard DA, Redding S, Narlikar GJ. PMID: 28636604; PMCID: PMC5606208.
      View in: PubMed   Mentions: 737     Fields:    Translation:HumansAnimalsCells
    61. Grafting both acute wound site and adjacent donor site with the same graft: an easy and safe procedure to improve healing and minimize pain in elderly and bedridden patients. Ann Burns Fire Disasters. 2017 Mar 31; 30(1):52-56. Keilani C, Agard D, Duhoux A, Lakhel A, Giraud O, Brachet M, Duhamel P, Bey E. PMID: 28592936; PMCID: PMC5446911.
      View in: PubMed   Mentions:
    62. Design of Allosteric Stimulators of the Hsp90 ATPase as New Anticancer Leads. Chemistry. 2017 Apr 19; 23(22):5188-5192. D'Annessa I, Sattin S, Tao J, Pennati M, Sànchez-Martìn C, Moroni E, Rasola A, Zaffaroni N, Agard DA, Bernardi A, Colombo G. PMID: 28207175; PMCID: PMC5927549.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    63. MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy. Nat Methods. 2017 04; 14(4):331-332. Zheng SQ, Palovcak E, Armache JP, Verba KA, Cheng Y, Agard DA. PMID: 28250466; PMCID: PMC5494038.
      View in: PubMed   Mentions: 3504     Fields:    
    64. Assembly of a nucleus-like structure during viral replication in bacteria. Science. 2017 01 13; 355(6321):194-197. Chaikeeratisak V, Nguyen K, Khanna K, Brilot AF, Erb ML, Coker JK, Vavilina A, Newton GL, Buschauer R, Pogliano K, Villa E, Agard DA, Pogliano J. PMID: 28082593; PMCID: PMC6028185.
      View in: PubMed   Mentions: 92     Fields:    Translation:Cells
    65. Internal Structure and Preferential Protein Binding of Colloidal Aggregates. ACS Chem Biol. 2017 01 20; 12(1):282-290. Duan D, Torosyan H, Elnatan D, McLaughlin CK, Logie J, Shoichet MS, Agard DA, Shoichet BK. PMID: 27983786; PMCID: PMC5491102.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    66. Atomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 traps and stabilizes an unfolded kinase. Science. 2016 Jun 24; 352(6293):1542-7. Verba KA, Wang RY, Arakawa A, Liu Y, Shirouzu M, Yokoyama S, Agard DA. PMID: 27339980; PMCID: PMC5373496.
      View in: PubMed   Mentions: 192     Fields:    Translation:HumansAnimalsCells
    67. Higher-order oligomerization of Spc110p drives γ-tubulin ring complex assembly. Mol Biol Cell. 2016 07 15; 27(14):2245-58. Lyon AS, Morin G, Moritz M, Yabut KC, Vojnar T, Zelter A, Muller E, Davis TN, Agard DA. PMID: 27226487; PMCID: PMC4945142.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    68. A Fortunate Story of an Unusual AK-47 Bullet Trajectory: Always Keep a Smartphone in Your Pocket. Prehosp Disaster Med. 2016 Jun; 31(3):343-5. Thabouillot O, Perrier P, Roche NC, Agard D, Barbier O, Martin G, Viant E, Leclere JB. PMID: 27086713.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    69. The Seckel syndrome and centrosomal protein Ninein localizes asymmetrically to stem cell centrosomes but is not required for normal development, behavior, or DNA damage response in Drosophila. Mol Biol Cell. 2016 06 01; 27(11):1740-52. Zheng Y, Mennella V, Marks S, Wildonger J, Elnagdi E, Agard D, Megraw TL. PMID: 27053665; PMCID: PMC4884065.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    70. Molecular Dynamics Simulations Reveal the Mechanisms of Allosteric Activation of Hsp90 by Designed Ligands. Sci Rep. 2016 Apr 01; 6:23830. Vettoretti G, Moroni E, Sattin S, Tao J, Agard DA, Bernardi A, Colombo G. PMID: 27032695; PMCID: PMC4817115.
      View in: PubMed   Mentions: 27     Fields:    Translation:Cells
    71. Structure of γ-tubulin small complex based on a cryo-EM map, chemical cross-links, and a remotely related structure. J Struct Biol. 2016 06; 194(3):303-10. Greenberg CH, Kollman J, Zelter A, Johnson R, MacCoss MJ, Davis TN, Agard DA, Sali A. PMID: 26968363; PMCID: PMC4866596.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    72. Clinical validation of Anyplex™ II HPV HR Detection according to the guidelines for HPV test requirements for cervical cancer screening. J Clin Virol. 2016 Mar; 76:36-9. Hesselink AT, Sahli R, Berkhof J, Snijders PJ, van der Salm ML, Agard D, Bleeker MC, Heideman DA. PMID: 26809131.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCellsPHPublic Health
    73. Activity-Independent Discovery of Secondary Metabolites Using Chemical Elicitation and Cheminformatic Inference. ACS Chem Biol. 2015 Nov 20; 10(11):2616-23. Pimentel-Elardo SM, Sørensen D, Ho L, Ziko M, Bueler SA, Lu S, Tao J, Moser A, Lee R, Agard D, Fairn G, Rubinstein JL, Shoichet BK, Nodwell JR. PMID: 26352211; PMCID: PMC4658348.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    74. Asynchronous data acquisition and on-the-fly analysis of dose fractionated cryoEM images by UCSFImage. J Struct Biol. 2015 Nov; 192(2):174-8. Li X, Zheng S, Agard DA, Cheng Y. PMID: 26370395; PMCID: PMC4633327.
      View in: PubMed   Mentions: 53     Fields:    
    75. Evaluation of super-resolution performance of the K2 electron-counting camera using 2D crystals of aquaporin-0. J Struct Biol. 2015 Nov; 192(2):163-73. Chiu PL, Li X, Li Z, Beckett B, Brilot AF, Grigorieff N, Agard DA, Cheng Y, Walz T. PMID: 26318383; PMCID: PMC4633381.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    76. Activation of Hsp90 Enzymatic Activity and Conformational Dynamics through Rationally Designed Allosteric Ligands. Chemistry. 2015 Sep 21; 21(39):13598-608. Sattin S, Tao J, Vettoretti G, Moroni E, Pennati M, Lopergolo A, Morelli L, Bugatti A, Zuehlke A, Moses M, Prince T, Kijima T, Beebe K, Rusnati M, Neckers L, Zaffaroni N, Agard DA, Bernardi A, Colombo G. PMID: 26286886; PMCID: PMC5921052.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    77. The cancer cell map initiative: defining the hallmark networks of cancer. Mol Cell. 2015 May 21; 58(4):690-8. Krogan NJ, Lippman S, Agard DA, Ashworth A, Ideker T. PMID: 26000852; PMCID: PMC5359018.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansCells
    78. Interaction of CK1δ with γTuSC ensures proper microtubule assembly and spindle positioning. Mol Biol Cell. 2015 Jul 01; 26(13):2505-18. Peng Y, Moritz M, Han X, Giddings TH, Lyon A, Kollman J, Winey M, Yates J, Agard DA, Drubin DG, Barnes G. PMID: 25971801; PMCID: PMC4571304.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    79. Hsp70 forms antiparallel dimers stabilized by post-translational modifications to position clients for transfer to Hsp90. Cell Rep. 2015 May 05; 11(5):759-69. Morgner N, Schmidt C, Beilsten-Edmands V, Ebong IO, Patel NA, Clerico EM, Kirschke E, Daturpalli S, Jackson SE, Agard D, Robinson CV. PMID: 25921532; PMCID: PMC4431665.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    80. MRC2014: Extensions to the MRC format header for electron cryo-microscopy and tomography. J Struct Biol. 2015 Nov; 192(2):146-50. Cheng A, Henderson R, Mastronarde D, Ludtke SJ, Schoenmakers RH, Short J, Marabini R, Dallakyan S, Agard D, Winn M. PMID: 25882513; PMCID: PMC4642651.
      View in: PubMed   Mentions: 31     Fields:    
    81. Ring closure activates yeast γTuRC for species-specific microtubule nucleation. Nat Struct Mol Biol. 2015 Feb; 22(2):132-7. Kollman JM, Greenberg CH, Li S, Moritz M, Zelter A, Fong KK, Fernandez JJ, Sali A, Kilmartin J, Davis TN, Agard DA. PMID: 25599398; PMCID: PMC4318760.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    82. A novel N-terminal extension in mitochondrial TRAP1 serves as a thermal regulator of chaperone activity. Elife. 2014 Dec 22; 3. Partridge JR, Lavery LA, Elnatan D, Naber N, Cooke R, Agard DA. PMID: 25531069; PMCID: PMC4381864.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    83. A bacteriophage tubulin harnesses dynamic instability to center DNA in infected cells. Elife. 2014 Nov 27; 3. Erb ML, Kraemer JA, Coker JK, Chaikeeratisak V, Nonejuie P, Agard DA, Pogliano J. PMID: 25429514; PMCID: PMC4244570.
      View in: PubMed   Mentions: 31     Fields:    Translation:Cells
    84. Glucocorticoid receptor function regulated by coordinated action of the Hsp90 and Hsp70 chaperone cycles. Cell. 2014 Jun 19; 157(7):1685-97. Kirschke E, Goswami D, Southworth D, Griffin PR, Agard DA. PMID: 24949977; PMCID: PMC4087167.
      View in: PubMed   Mentions: 198     Fields:    Translation:HumansCells
    85. Elucidating the mechanism of substrate recognition by the bacterial Hsp90 molecular chaperone. J Mol Biol. 2014 Jun 12; 426(12):2393-404. Street TO, Zeng X, Pellarin R, Bonomi M, Sali A, Kelly MJ, Chu F, Agard DA. PMID: 24726919; PMCID: PMC5322795.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    86. Sparse labeling of proteins: structural characterization from long range constraints. J Magn Reson. 2014 Apr; 241:32-40. Prestegard JH, Agard DA, Moremen KW, Lavery LA, Morris LC, Pederson K. PMID: 24656078; PMCID: PMC3964372.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    87. Microarray-based screening of heat shock protein inhibitors. J Biotechnol. 2014 Jun 20; 180:1-9. Schax E, Walter JG, Märzhäuser H, Stahl F, Scheper T, Agard DA, Eichner S, Kirschning A, Zeilinger C. PMID: 24667540.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    88. The structure and assembly mechanism of a novel three-stranded tubulin filament that centers phage DNA. Structure. 2014 Apr 08; 22(4):539-48. Zehr EA, Kraemer JA, Erb ML, Coker JK, Montabana EA, Pogliano J, Agard DA. PMID: 24631461; PMCID: PMC3999902.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    89. Bacterial tubulin TubZ-Bt transitions between a two-stranded intermediate and a four-stranded filament upon GTP hydrolysis. Proc Natl Acad Sci U S A. 2014 Mar 04; 111(9):3407-12. Montabana EA, Agard DA. PMID: 24550513; PMCID: PMC3948286.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    90. The free energy profile of tubulin straight-bent conformational changes, with implications for microtubule assembly and drug discovery. PLoS Comput Biol. 2014 Feb; 10(2):e1003464. Peng LX, Hsu MT, Bonomi M, Agard DA, Jacobson MP. PMID: 24516374; PMCID: PMC3916224.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    91. Structural asymmetry in the closed state of mitochondrial Hsp90 (TRAP1) supports a two-step ATP hydrolysis mechanism. Mol Cell. 2014 Jan 23; 53(2):330-43. Lavery LA, Partridge JR, Ramelot TA, Elnatan D, Kennedy MA, Agard DA. PMID: 24462206; PMCID: PMC3947485.
      View in: PubMed   Mentions: 75     Fields:    Translation:Cells
    92. Amorphous no more: subdiffraction view of the pericentriolar material architecture. Trends Cell Biol. 2014 Mar; 24(3):188-97. Mennella V, Agard DA, Huang B, Pelletier L. PMID: 24268653; PMCID: PMC3991556.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansCells
    93. A new approach for the laboratory culture of the fathead minnow, Pimephales promelas. Environ Toxicol Chem. 2014 Jan; 33(1):126-33. Gordon DA, Smith ME, Wratschko M, Agard D, Holden L, Wilcox S, Lazorchak JM. PMID: 24115165.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    94. Cell-cycle regulation of formin-mediated actin cable assembly. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):E4446-55. Miao Y, Wong CC, Mennella V, Michelot A, Agard DA, Holt LJ, Yates JR, Drubin DG. PMID: 24133141; PMCID: PMC3839727.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    95. High-resolution restoration of 3D structures from widefield images with extreme low signal-to-noise-ratio. Proc Natl Acad Sci U S A. 2013 Oct 22; 110(43):17344-9. Arigovindan M, Fung JC, Elnatan D, Mennella V, Chan YH, Pollard M, Branlund E, Sedat JW, Agard DA. PMID: 24106307; PMCID: PMC3808589.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    96. The Aptima HPV assay fulfills the cross-sectional clinical and reproducibility criteria of international guidelines for human papillomavirus test requirements for cervical screening. J Clin Microbiol. 2013 Nov; 51(11):3653-7. Heideman DA, Hesselink AT, van Kemenade FJ, Iftner T, Berkhof J, Topal F, Agard D, Meijer CJ, Snijders PJ. PMID: 23985912; PMCID: PMC3889747.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    97. Influence of electron dose rate on electron counting images recorded with the K2 camera. J Struct Biol. 2013 Nov; 184(2):251-60. Li X, Zheng SQ, Egami K, Agard DA, Cheng Y. PMID: 23968652; PMCID: PMC3854003.
      View in: PubMed   Mentions: 43     Fields:    Translation:Cells
    98. Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM. Nat Methods. 2013 Jun; 10(6):584-90. Li X, Mooney P, Zheng S, Booth CR, Braunfeld MB, Gubbens S, Agard DA, Cheng Y. PMID: 23644547; PMCID: PMC3684049.
      View in: PubMed   Mentions: 990     Fields:    Translation:Cells
    99. Uncovering a region of heat shock protein 90 important for client binding in E. coli and chaperone function in yeast. Mol Cell. 2013 Feb 07; 49(3):464-73. Genest O, Reidy M, Street TO, Hoskins JR, Camberg JL, Agard DA, Masison DC, Wickner S. PMID: 23260660; PMCID: PMC3570620.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    100. Fast multicolor 3D imaging using aberration-corrected multifocus microscopy. Nat Methods. 2013 Jan; 10(1):60-3. Abrahamsson S, Chen J, Hajj B, Stallinga S, Katsov AY, Wisniewski J, Mizuguchi G, Soule P, Mueller F, Dugast Darzacq C, Darzacq X, Wu C, Bargmann CI, Agard DA, Dahan M, Gustafsson MG. PMID: 23223154; PMCID: PMC4161287.
      View in: PubMed   Mentions: 164     Fields:    Translation:HumansAnimalsCells
    101. The bacterial actin MamK: in vitro assembly behavior and filament architecture. J Biol Chem. 2013 Feb 08; 288(6):4265-77. Ozyamak E, Kollman J, Agard DA, Komeili A. PMID: 23204522; PMCID: PMC3567678.
      View in: PubMed   Mentions: 37     Fields:    Translation:Cells
    102. A method for integrative structure determination of protein-protein complexes. Bioinformatics. 2012 Dec 15; 28(24):3282-9. Schneidman-Duhovny D, Rossi A, Avila-Sakar A, Kim SJ, Velázquez-Muriel J, Strop P, Liang H, Krukenberg KA, Liao M, Kim HM, Sobhanifar S, Dötsch V, Rajpal A, Pons J, Agard DA, Cheng Y, Sali A. PMID: 23093611; PMCID: PMC3519461.
      View in: PubMed   Mentions: 36     Fields:    Translation:Cells
    103. Subdiffraction-resolution fluorescence microscopy reveals a domain of the centrosome critical for pericentriolar material organization. Nat Cell Biol. 2012 Nov; 14(11):1159-68. Mennella V, Keszthelyi B, McDonald KL, Chhun B, Kan F, Rogers GC, Huang B, Agard DA. PMID: 23086239; PMCID: PMC3767400.
      View in: PubMed   Mentions: 198     Fields:    Translation:HumansCells
    104. The conserved arginine 380 of Hsp90 is not a catalytic residue, but stabilizes the closed conformation required for ATP hydrolysis. Protein Sci. 2012 Aug; 21(8):1162-71. Cunningham CN, Southworth DR, Krukenberg KA, Agard DA. PMID: 22653663; PMCID: PMC3537237.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    105. A phage tubulin assembles dynamic filaments by an atypical mechanism to center viral DNA within the host cell. Cell. 2012 Jun 22; 149(7):1488-99. Kraemer JA, Erb ML, Waddling CA, Montabana EA, Zehr EA, Wang H, Nguyen K, Pham DS, Agard DA, Pogliano J. PMID: 22726436; PMCID: PMC3401054.
      View in: PubMed   Mentions: 59     Fields:    Translation:Cells
    106. Functional modulation of a protein folding landscape via side-chain distortion. Proc Natl Acad Sci U S A. 2012 Jun 12; 109(24):9414-9. Kelch BA, Salimi NL, Agard DA. PMID: 22635267; PMCID: PMC3386061.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    107. Interferometer-based structured-illumination microscopy utilizing complementary phase relationship through constructive and destructive image detection by two cameras. J Microsc. 2012 Jun; 246(3):229-36. Shao L, Winoto L, Agard DA, Gustafsson MG, Sedat JW. PMID: 22472010; PMCID: PMC3447539.
      View in: PubMed   Mentions: 3     Fields:    
    108. Effect of depth dependent spherical aberrations in 3D structured illumination microscopy. Opt Express. 2012 Mar 12; 20(6):6527-41. Arigovindan M, Sedat JW, Agard DA. PMID: 22418536.
      View in: PubMed   Mentions: 11     Fields:    
    109. Three-dimensional structure of basal body triplet revealed by electron cryo-tomography. EMBO J. 2012 Feb 01; 31(3):552-62. Li S, Fernandez JJ, Marshall WF, Agard DA. PMID: 22157822; PMCID: PMC3273388.
      View in: PubMed   Mentions: 78     Fields:    Translation:Cells
    110. Cross-monomer substrate contacts reposition the Hsp90 N-terminal domain and prime the chaperone activity. J Mol Biol. 2012 Jan 06; 415(1):3-15. Street TO, Lavery LA, Verba KA, Lee CT, Mayer MP, Agard DA. PMID: 22063096; PMCID: PMC3282117.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    111. Microtubule nucleation by γ-tubulin complexes. Nat Rev Mol Cell Biol. 2011 Oct 12; 12(11):709-21. Kollman JM, Merdes A, Mourey L, Agard DA. PMID: 21993292; PMCID: PMC7183383.
      View in: PubMed   Mentions: 227     Fields:    Translation:HumansAnimalsCells
    112. A small molecule that preferentially binds the closed conformation of Hsp90. Bioorg Med Chem Lett. 2011 Dec 01; 21(23):7068-71. Alexander LD, Partridge JR, Agard DA, McAlpine SR. PMID: 22014826.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    113. Crystal structure of γ-tubulin complex protein GCP4 provides insight into microtubule nucleation. Nat Struct Mol Biol. 2011 Jul 03; 18(8):915-9. Guillet V, Knibiehler M, Gregory-Pauron L, Remy MH, Chemin C, Raynaud-Messina B, Bon C, Kollman JM, Agard DA, Merdes A, Mourey L. PMID: 21725292; PMCID: PMC3703858.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    114. Client-loading conformation of the Hsp90 molecular chaperone revealed in the cryo-EM structure of the human Hsp90:Hop complex. Mol Cell. 2011 Jun 24; 42(6):771-81. Southworth DR, Agard DA. PMID: 21700222; PMCID: PMC3144320.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansCells
    115. Sas-4 provides a scaffold for cytoplasmic complexes and tethers them in a centrosome. Nat Commun. 2011 Jun 21; 2:359. Gopalakrishnan J, Mennella V, Blachon S, Zhai B, Smith AH, Megraw TL, Nicastro D, Gygi SP, Agard DA, Avidor-Reiss T. PMID: 21694707; PMCID: PMC3677532.
      View in: PubMed   Mentions: 80     Fields:    Translation:AnimalsCells
    116. Substrate binding drives large-scale conformational changes in the Hsp90 molecular chaperone. Mol Cell. 2011 Apr 08; 42(1):96-105. Street TO, Lavery LA, Agard DA. PMID: 21474071; PMCID: PMC3105473.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansCells
    117. A distributed multi-GPU system for high speed electron microscopic tomographic reconstruction. Ultramicroscopy. 2011 Jul; 111(8):1137-43. Zheng SQ, Branlund E, Kesthelyi B, Braunfeld MB, Cheng Y, Sedat JW, Agard DA. PMID: 21741915; PMCID: PMC3190582.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    118. Conformational dynamics of the molecular chaperone Hsp90. Q Rev Biophys. 2011 May; 44(2):229-55. Krukenberg KA, Street TO, Lavery LA, Agard DA. PMID: 21414251; PMCID: PMC5070531.
      View in: PubMed   Mentions: 130     Fields:    Translation:HumansAnimalsCells
    119. Architecture and assembly of a divergent member of the ParM family of bacterial actin-like proteins. J Biol Chem. 2011 Apr 22; 286(16):14282-90. Rivera CR, Kollman JM, Polka JK, Agard DA, Mullins RD. PMID: 21339292; PMCID: PMC3077629.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    120. An improved strategy for generating forces in steered molecular dynamics: the mechanical unfolding of titin, e2lip3 and ubiquitin. PLoS One. 2010 Sep 29; 5(9). Ho BK, Agard DA. PMID: 20927369; PMCID: PMC2947501.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    121. Condensed mitotic chromosome structure at nanometer resolution using PALM and EGFP- histones. PLoS One. 2010 Sep 15; 5(9):e12768. Matsuda A, Shao L, Boulanger J, Kervrann C, Carlton PM, Kner P, Agard D, Sedat JW. PMID: 20856676; PMCID: PMC2939896.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    122. Fast live simultaneous multiwavelength four-dimensional optical microscopy. Proc Natl Acad Sci U S A. 2010 Sep 14; 107(37):16016-22. Carlton PM, Boulanger J, Kervrann C, Sibarita JB, Salamero J, Gordon-Messer S, Bressan D, Haber JE, Haase S, Shao L, Winoto L, Matsuda A, Kner P, Uzawa S, Gustafsson M, Kam Z, Agard DA, Sedat JW. PMID: 20705899; PMCID: PMC2941331.
      View in: PubMed   Mentions: 84     Fields:    Translation:Animals
    123. Microtubule nucleating gamma-TuSC assembles structures with 13-fold microtubule-like symmetry. Nature. 2010 Aug 12; 466(7308):879-82. Kollman JM, Polka JK, Zelter A, Davis TN, Agard DA. PMID: 20631709; PMCID: PMC2921000.
      View in: PubMed   Mentions: 129     Fields:    Translation:AnimalsCells
    124. High-performance iterative electron tomography reconstruction with long-object compensation using graphics processing units (GPUs). J Struct Biol. 2010 Aug; 171(2):142-53. Xu W, Xu F, Jones M, Keszthelyi B, Sedat J, Agard D, Mueller K. PMID: 20371381; PMCID: PMC2885506.
      View in: PubMed   Mentions: 9     Fields:    
    125. A Parallel Product-Convolution approach for representing the depth varying Point Spread Functions in 3D widefield microscopy based on principal component analysis. Opt Express. 2010 Mar 29; 18(7):6461-76. Arigovindan M, Shaevitz J, McGowan J, Sedat JW, Agard DA. PMID: 20389670.
      View in: PubMed   Mentions: 5     Fields:    
    126. Conserved tertiary couplings stabilize elements in the PDZ fold, leading to characteristic patterns of domain conformational flexibility. Protein Sci. 2010 Mar; 19(3):398-411. Ho BK, Agard DA. PMID: 20052683; PMCID: PMC2866267.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    127. Unfolding simulations reveal the mechanism of extreme unfolding cooperativity in the kinetically stable alpha-lytic protease. PLoS Comput Biol. 2010 Feb 26; 6(2):e1000689. Salimi NL, Ho B, Agard DA. PMID: 20195497; PMCID: PMC2829044.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    128. Closed loop adaptive optics for microscopy without a wavefront sensor. Proc SPIE Int Soc Opt Eng. 2010 Feb 24; 7570. Kner P, Winoto L, Agard DA, Sedat JW. PMID: 24392198; PMCID: PMC3877333.
      View in: PubMed   Mentions: 7  
    129. High-resolution wide-field microscopy with adaptive optics for spherical aberration correction and motionless focusing. J Microsc. 2010 Feb; 237(2):136-47. Kner P, Sedat JW, Agard DA, Kam Z. PMID: 20096044; PMCID: PMC2897157.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    130. Self-assembling SAS-6 multimer is a core centriole building block. J Biol Chem. 2010 Mar 19; 285(12):8759-70. Gopalakrishnan J, Guichard P, Smith AH, Schwarz H, Agard DA, Marco S, Avidor-Reiss T. PMID: 20083610; PMCID: PMC2838298.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    131. Mechanistic studies of Sansalvamide A-amide: an allosteric modulator of Hsp90. ACS Med Chem Lett. 2010 Jan 01; 1(1):4-8. Vasko RC, Rodriguez RA, Cunningham CN, Ardi VC, Agard DA, McAlpine SR. PMID: 20730035; PMCID: PMC2922868.
      View in: PubMed   Mentions: 41  
    132. Automated data collection for electron microscopic tomography. Methods Enzymol. 2010; 481:283-315. Zheng SQ, Sedat JW, Agard DA. PMID: 20887862.
      View in: PubMed   Mentions: 10     Fields:    
    133. Osmolyte-induced conformational changes in the Hsp90 molecular chaperone. Protein Sci. 2010 Jan; 19(1):57-65. Street TO, Krukenberg KA, Rosgen J, Bolen DW, Agard DA. PMID: 19890989; PMCID: PMC2817839.
      View in: PubMed   Mentions: 30     Fields:    Translation:Cells
    134. On the efficiency of iterative ordered subset reconstruction algorithms for acceleration on GPUs. Comput Methods Programs Biomed. 2010 Jun; 98(3):261-70. Xu F, Xu W, Jones M, Keszthelyi B, Sedat J, Agard D, Mueller K. PMID: 19850372; PMCID: PMC2871068.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    135. Grp94, the endoplasmic reticulum Hsp90, has a similar solution conformation to cytosolic Hsp90 in the absence of nucleotide. Protein Sci. 2009 Sep; 18(9):1815-27. Krukenberg KA, Böttcher UM, Southworth DR, Agard DA. PMID: 19554567; PMCID: PMC2777357.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    136. Localization and orientation of the gamma-tubulin small complex components using protein tags as labels for single particle EM. J Struct Biol. 2009 Dec; 168(3):571-4. Choy RM, Kollman JM, Zelter A, Davis TN, Agard DA. PMID: 19723581; PMCID: PMC2793330.
      View in: PubMed   Mentions: 18     Fields:    
    137. The structure and assembly dynamics of plasmid actin AlfA imply a novel mechanism of DNA segregation. J Bacteriol. 2009 Oct; 191(20):6219-30. Polka JK, Kollman JM, Agard DA, Mullins RD. PMID: 19666709; PMCID: PMC2753045.
      View in: PubMed   Mentions: 42     Fields:    Translation:Cells
    138. Dual-axis target mapping and automated sequential acquisition of dual-axis EM tomographic data. J Struct Biol. 2009 Nov; 168(2):323-31. Zheng SQ, Matsuda A, Braunfeld MB, Sedat JW, Agard DA. PMID: 19545637; PMCID: PMC2776717.
      View in: PubMed   Mentions: 5     Fields:    
    139. pH-dependent conformational changes in bacterial Hsp90 reveal a Grp94-like conformation at pH 6 that is highly active in suppression of citrate synthase aggregation. J Mol Biol. 2009 Jul 10; 390(2):278-91. Krukenberg KA, Southworth DR, Street TO, Agard DA. PMID: 19427321; PMCID: PMC2735500.
      View in: PubMed   Mentions: 30     Fields:    Translation:Cells
    140. Fully automated, sequential tilt-series acquisition with Leginon. J Struct Biol. 2009 Jul; 167(1):11-8. Suloway C, Shi J, Cheng A, Pulokas J, Carragher B, Potter CS, Zheng SQ, Agard DA, Jensen GJ. PMID: 19361558; PMCID: PMC2724967.
      View in: PubMed   Mentions: 100     Fields:    
    141. Probing the flexibility of large conformational changes in protein structures through local perturbations. PLoS Comput Biol. 2009 Apr; 5(4):e1000343. Ho BK, Agard DA. PMID: 19343225; PMCID: PMC2660149.
      View in: PubMed   Mentions: 27     Fields:    Translation:Cells
    142. Species-dependent ensembles of conserved conformational states define the Hsp90 chaperone ATPase cycle. Mol Cell. 2008 Dec 05; 32(5):631-40. Southworth DR, Agard DA. PMID: 19061638; PMCID: PMC2633443.
      View in: PubMed   Mentions: 119     Fields:    Translation:HumansAnimalsCells
    143. How general is the nucleation-condensation mechanism? Proteins. 2008 Nov 15; 73(3):754-64. Nölting B, Agard DA. PMID: 18498109; PMCID: PMC2776727.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    144. Identification of new, well-populated amino-acid sidechain rotamers involving hydroxyl-hydrogen atoms and sulfhydryl-hydrogen atoms. BMC Struct Biol. 2008 Oct 07; 8:41. Ho BK, Agard DA. PMID: 18840291; PMCID: PMC2569941.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    145. Integration of small-angle X-ray scattering data into structural modeling of proteins and their assemblies. J Mol Biol. 2008 Oct 17; 382(4):1089-106. Förster F, Webb B, Krukenberg KA, Tsuruta H, Agard DA, Sali A. PMID: 18694757; PMCID: PMC2745287.
      View in: PubMed   Mentions: 68     Fields:    Translation:Cells
    146. Subdiffraction multicolor imaging of the nuclear periphery with 3D structured illumination microscopy. Science. 2008 Jun 06; 320(5881):1332-6. Schermelleh L, Carlton PM, Haase S, Shao L, Winoto L, Kner P, Burke B, Cardoso MC, Agard DA, Gustafsson MG, Leonhardt H, Sedat JW. PMID: 18535242; PMCID: PMC2916659.
      View in: PubMed   Mentions: 459     Fields:    Translation:AnimalsCells
    147. Intra- and intermonomer interactions are required to synergistically facilitate ATP hydrolysis in Hsp90. J Biol Chem. 2008 Jul 25; 283(30):21170-8. Cunningham CN, Krukenberg KA, Agard DA. PMID: 18492664; PMCID: PMC2475720.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    148. Multiple conformations of E. coli Hsp90 in solution: insights into the conformational dynamics of Hsp90. Structure. 2008 May; 16(5):755-65. Krukenberg KA, Förster F, Rice LM, Sali A, Agard DA. PMID: 18462680; PMCID: PMC2600884.
      View in: PubMed   Mentions: 92     Fields:    Translation:Cells
    149. Mob4 plays a role in spindle focusing in Drosophila S2 cells. J Cell Sci. 2008 Apr 15; 121(Pt 8):1284-92. Trammell MA, Mahoney NM, Agard DA, Vale RD. PMID: 18388316; PMCID: PMC2851640.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    150. The lattice as allosteric effector: structural studies of alphabeta- and gamma-tubulin clarify the role of GTP in microtubule assembly. Proc Natl Acad Sci U S A. 2008 Apr 08; 105(14):5378-83. Rice LM, Montabana EA, Agard DA. PMID: 18388201; PMCID: PMC2291134.
      View in: PubMed   Mentions: 121     Fields:    Translation:Cells
    151. Three-dimensional resolution doubling in wide-field fluorescence microscopy by structured illumination. Biophys J. 2008 Jun; 94(12):4957-70. Gustafsson MG, Shao L, Carlton PM, Wang CJ, Golubovskaya IN, Cande WZ, Agard DA, Sedat JW. PMID: 18326650; PMCID: PMC2397368.
      View in: PubMed   Mentions: 531     Fields:    
    152. I5S: wide-field light microscopy with 100-nm-scale resolution in three dimensions. Biophys J. 2008 Jun; 94(12):4971-83. Shao L, Isaac B, Uzawa S, Agard DA, Sedat JW, Gustafsson MG. PMID: 18326649; PMCID: PMC2397336.
      View in: PubMed   Mentions: 37     Fields:    
    153. The structure of the gamma-tubulin small complex: implications of its architecture and flexibility for microtubule nucleation. Mol Biol Cell. 2008 Jan; 19(1):207-15. Kollman JM, Zelter A, Muller EG, Fox B, Rice LM, Davis TN, Agard DA. PMID: 17978090; PMCID: PMC2174199.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    154. AIDA: an adaptive image deconvolution algorithm with application to multi-frame and three-dimensional data. J Opt Soc Am A Opt Image Sci Vis. 2007 Jun; 24(6):1580-600. Hom EF, Marchis F, Lee TK, Haase S, Agard DA, Sedat JW. PMID: 17491626; PMCID: PMC3166524.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    155. Mesophile versus thermophile: insights into the structural mechanisms of kinetic stability. J Mol Biol. 2007 Jul 20; 370(4):784-95. Kelch BA, Agard DA. PMID: 17543987.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    156. Modelling the application of adaptive optics to wide-field microscope live imaging. J Microsc. 2007 Apr; 226(Pt 1):33-42. Kam Z, Kner P, Agard D, Sedat JW. PMID: 17381707.
      View in: PubMed   Mentions: 16     Fields:    
    157. The three-dimensional structure of in vitro reconstituted Xenopus laevis chromosomes by EM tomography. Chromosoma. 2007 Aug; 116(4):349-72. König P, Braunfeld MB, Sedat JW, Agard DA. PMID: 17333236.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    158. Structural and mechanistic exploration of acid resistance: kinetic stability facilitates evolution of extremophilic behavior. J Mol Biol. 2007 May 04; 368(3):870-83. Kelch BA, Eagen KP, Erciyas FP, Humphris EL, Thomason AR, Mitsuiki S, Agard DA. PMID: 17382344.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    159. Automated acquisition of electron microscopic random conical tilt sets. J Struct Biol. 2007 Jan; 157(1):148-55. Zheng SQ, Kollman JM, Braunfeld MB, Sedat JW, Agard DA. PMID: 17169745; PMCID: PMC2556511.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    160. Structural Analysis of E. coli hsp90 reveals dramatic nucleotide-dependent conformational rearrangements. Cell. 2006 Oct 20; 127(2):329-40. Shiau AK, Harris SF, Southworth DR, Agard DA. PMID: 17055434.
      View in: PubMed   Mentions: 216     Fields:    Translation:Cells
    161. Tunable instability mechanisms of polymer thin films by molecular self-assembly. Langmuir. 2006 Oct 10; 22(21):8642-5. Wei B, Lam PG, Braunfeld MB, Agard DA, Genzer J, Spontak RJ. PMID: 17014099.
      View in: PubMed   Mentions:    Fields:    
    162. Electron energy filtering significantly improves amplitude contrast of frozen-hydrated protein at 300kV. J Struct Biol. 2006 Dec; 156(3):524-36. Yonekura K, Braunfeld MB, Maki-Yonekura S, Agard DA. PMID: 16987672.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    163. Subangstrom crystallography reveals that short ionic hydrogen bonds, and not a His-Asp low-barrier hydrogen bond, stabilize the transition state in serine protease catalysis. J Am Chem Soc. 2006 Jul 19; 128(28):9086-102. Fuhrmann CN, Daugherty MD, Agard DA. PMID: 16834383.
      View in: PubMed   Mentions: 36     Fields:    Translation:Cells
    164. UCSF tomography: an integrated software suite for real-time electron microscopic tomographic data collection, alignment, and reconstruction. J Struct Biol. 2007 Jan; 157(1):138-47. Zheng SQ, Keszthelyi B, Branlund E, Lyle JM, Braunfeld MB, Sedat JW, Agard DA. PMID: 16904341.
      View in: PubMed   Mentions: 107     Fields:    Translation:HumansCells
    165. The folding landscape of an alpha-lytic protease variant reveals the role of a conserved beta-hairpin in the development of kinetic stability. Proteins. 2005 Oct 01; 61(1):105-14. Truhlar SM, Agard DA. PMID: 16044461.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    166. Intramolecular signaling pathways revealed by modeling anisotropic thermal diffusion. J Mol Biol. 2005 Aug 12; 351(2):345-54. Ota N, Agard DA. PMID: 16005893.
      View in: PubMed   Mentions: 83     Fields:    Translation:AnimalsCells
    167. A novel 3D wavelet-based filter for visualizing features in noisy biological data. J Microsc. 2005 Aug; 219(Pt 2):43-9. Moss WC, Haase S, Lyle JM, Agard DA, Sedat JW. PMID: 16159339.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    168. Insights into microtubule nucleation from the crystal structure of human gamma-tubulin. Nature. 2005 May 26; 435(7041):523-7. Aldaz H, Rice LM, Stearns T, Agard DA. PMID: 15917813.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansCells
    169. Comprehensive analysis of protein folding activation thermodynamics reveals a universal behavior violated by kinetically stable proteases. J Mol Biol. 2005 Mar 25; 347(2):355-66. Jaswal SS, Truhlar SM, Dill KA, Agard DA. PMID: 15740746.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    170. Use of surface affinity enrichment and cryo-embedding to prepare in vitro reconstituted mitotic chromosomes for EM tomography. Ultramicroscopy. 2005 Jul; 103(4):261-74. König P, Braunfeld M, Agard DA. PMID: 15885431.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    171. Suite of three protein crystallography beamlines with single superconducting bend magnet as the source. J Synchrotron Radiat. 2004 Nov 01; 11(Pt 6):447-55. MacDowell AA, Celestre RS, Howells M, McKinney W, Krupnick J, Cambie D, Domning EE, Duarte RM, Kelez N, Plate DW, Cork CW, Earnest TN, Dickert J, Meigs G, Ralston C, Holton JM, Alber T, Berger JM, Agard DA, Padmore HA. PMID: 15496731.
      View in: PubMed   Mentions: 41     Fields:    Translation:Cells
    172. Phase-retrieved pupil functions in wide-field fluorescence microscopy. J Microsc. 2004 Oct; 216(Pt 1):32-48. Hanser BM, Gustafsson MG, Agard DA, Sedat JW. PMID: 15369481.
      View in: PubMed   Mentions: 59     Fields:    
    173. Spindle pole body duplication in fission yeast occurs at the G1/S boundary but maturation is blocked until exit from S by an event downstream of cdc10+. Mol Biol Cell. 2004 Dec; 15(12):5219-30. Uzawa S, Li F, Jin Y, McDonald KL, Braunfeld MB, Agard DA, Cande WZ. PMID: 15385623; PMCID: PMC532005.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    174. An improved strategy for automated electron microscopic tomography. J Struct Biol. 2004 Aug; 147(2):91-101. Zheng QS, Braunfeld MB, Sedat JW, Agard DA. PMID: 15193638.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimals
    175. The crystal structure of the carboxy-terminal dimerization domain of htpG, the Escherichia coli Hsp90, reveals a potential substrate binding site. Structure. 2004 Jun; 12(6):1087-97. Harris SF, Shiau AK, Agard DA. PMID: 15274928.
      View in: PubMed   Mentions: 79     Fields:    Translation:Cells
    176. The 0.83 A resolution crystal structure of alpha-lytic protease reveals the detailed structure of the active site and identifies a source of conformational strain. J Mol Biol. 2004 May 14; 338(5):999-1013. Fuhrmann CN, Kelch BA, Ota N, Agard DA. PMID: 15111063.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    177. Disabling the folding catalyst is the last critical step in alpha-lytic protease folding. Protein Sci. 2004 Feb; 13(2):325-31. Cunningham EL, Agard DA. PMID: 14739318; PMCID: PMC2286698.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    178. The folding landscape of Streptomyces griseus protease B reveals the energetic costs and benefits associated with evolving kinetic stability. Protein Sci. 2004 Feb; 13(2):381-90. Truhlar SM, Cunningham EL, Agard DA. PMID: 14718653; PMCID: PMC2286692.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    179. Interdependent folding of the N- and C-terminal domains defines the cooperative folding of alpha-lytic protease. Biochemistry. 2003 Nov 18; 42(45):13212-9. Cunningham EL, Agard DA. PMID: 14609332.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    180. Phase retrieval for high-numerical-aperture optical systems. Opt Lett. 2003 May 15; 28(10):801-3. Hanser BM, Gustafsson MG, Agard DA, Sedat JW. PMID: 12779151.
      View in: PubMed   Mentions: 21     Fields:    
    181. Assessment of the role of computations in structural biology. Adv Protein Chem. 2003; 66:1-25. Kuntz ID, Agard DA. PMID: 14631815.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    182. The pro region N-terminal domain provides specific interactions required for catalysis of alpha-lytic protease folding. Biochemistry. 2002 Jul 16; 41(28):8860-7. Cunningham EL, Mau T, Truhlar SM, Agard DA. PMID: 12102628.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    183. Structural studies of the scrapie prion protein by electron crystallography. Proc Natl Acad Sci U S A. 2002 Mar 19; 99(6):3563-8. Wille H, Michelitsch MD, Guenebaut V, Supattapone S, Serban A, Cohen FE, Agard DA, Prusiner SB. PMID: 11891310; PMCID: PMC122563.
      View in: PubMed   Mentions: 126     Fields:    Translation:AnimalsCells
    184. Energetic landscape of alpha-lytic protease optimizes longevity through kinetic stability. Nature. 2002 Jan 17; 415(6869):343-6. Jaswal SS, Sohl JL, Davis JH, Agard DA. PMID: 11797014.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    185. The solution structure of the viral binding domain of Tva, the cellular receptor for subgroup A avian leukosis and sarcoma virus. FEBS Lett. 2001 Dec 07; 509(2):161-8. Tonelli M, Peters RJ, James TL, Agard DA. PMID: 11768384.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    186. GCP5 and GCP6: two new members of the human gamma-tubulin complex. Mol Biol Cell. 2001 Nov; 12(11):3340-52. Murphy SM, Preble AM, Patel UK, O'Connell KL, Dias DP, Moritz M, Agard D, Stults JT, Stearns T. PMID: 11694571; PMCID: PMC60259.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimalsCells
    187. Enzyme specificity under dynamic control II: Principal component analysis of alpha-lytic protease using global and local solvent boundary conditions. Protein Sci. 2001 Jul; 10(7):1403-14. Ota N, Agard DA. PMID: 11420442; PMCID: PMC2374101.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    188. Chromosome elasticity and mitotic polar ejection force measured in living Drosophila embryos by four-dimensional microscopy-based motion analysis. Curr Biol. 2001 Apr 17; 11(8):569-78. Marshall WF, Marko JF, Agard DA, Sedat JW. PMID: 11369201.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    189. Gamma-tubulin complexes and microtubule nucleation. Curr Opin Struct Biol. 2001 Apr; 11(2):174-81. Moritz M, Agard DA. PMID: 11297925.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    190. Computational adaptive optics for live three-dimensional biological imaging. Proc Natl Acad Sci U S A. 2001 Mar 27; 98(7):3790-5. Kam Z, Hanser B, Gustafsson MG, Agard DA, Sedat JW. PMID: 11274396; PMCID: PMC31131.
      View in: PubMed   Mentions: 27     Fields:    Translation:Animals
    191. Reconstitution of centrosome microtubule nucleation in Drosophila. Methods Cell Biol. 2001; 67:141-8. Moritz M, Braunfeld MB, Alberts BM, Agard DA. PMID: 11550465.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    192. Estrogen receptor pathways to AP-1. J Steroid Biochem Mol Biol. 2000 Nov 30; 74(5):311-7. Kushner PJ, Agard DA, Greene GL, Scanlan TS, Shiau AK, Uht RM, Webb P. PMID: 11162939.
      View in: PubMed   Mentions: 267     Fields:    Translation:HumansAnimalsCells
    193. Structure of the gamma-tubulin ring complex: a template for microtubule nucleation. Nat Cell Biol. 2000 Jun; 2(6):365-70. Moritz M, Braunfeld MB, Guénebaut V, Heuser J, Agard DA. PMID: 10854328.
      View in: PubMed   Mentions: 124     Fields:    Translation:AnimalsCells
    194. Two energetically disparate folding pathways of alpha-lytic protease share a single transition state. Nat Struct Biol. 2000 May; 7(5):394-7. Derman AI, Agard DA. PMID: 10802737.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    195. Evidence for the coincident initiation of homolog pairing and synapsis during the telomere-clustering (bouquet) stage of meiotic prophase. J Cell Sci. 2000 Mar; 113 ( Pt 6):1033-42. Bass HW, Riera-Lizarazu O, Ananiev EV, Bordoli SJ, Rines HW, Phillips RL, Sedat JW, Agard DA, Cande WZ. PMID: 10683151.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    196. Direct measurement of interfacial curvature distributions in a bicontinuous block copolymer morphology. Phys Rev Lett. 2000 Jan 17; 84(3):518-21. Jinnai H, Nishikawa Y, Spontak RJ, Smith SD, Agard DA, Hashimoto T. PMID: 11015953.
      View in: PubMed   Mentions: 2     Fields:    
    197. Oestrogen receptor function at classical and alternative response elements. Novartis Found Symp. 2000; 230:20-6; discussion 27-40. Kushner PJ, Agard D, Feng WJ, Lopez G, Schiau A, Uht R, Webb P, Greene G. PMID: 10965500.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    198. Kinetic stability as a mechanism for protease longevity. Proc Natl Acad Sci U S A. 1999 Sep 28; 96(20):11008-14. Cunningham EL, Jaswal SS, Sohl JL, Agard DA. PMID: 10500115; PMCID: PMC34233.
      View in: PubMed   Mentions: 28     Fields:    Translation:Cells
    199. I5M: 3D widefield light microscopy with better than 100 nm axial resolution. J Microsc. 1999 Jul; 195(Pt 1):10-6. Gustafsson MG, Agard DA, Sedat JW. PMID: 10444297.
      View in: PubMed   Mentions: 79     Fields:    Translation:Cells
    200. alpha-lytic protease precursor: characterization of a structured folding intermediate. Biochemistry. 1999 Apr 13; 38(15):4728-35. Anderson DE, Peters RJ, Wilk B, Agard DA. PMID: 10200160.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    201. Enzyme specificity under dynamic control: a normal mode analysis of alpha-lytic protease. J Mol Biol. 1999 Feb 12; 286(1):267-78. Miller DW, Agard DA. PMID: 9931265.
      View in: PubMed   Mentions: 25     Fields:    Translation:Cells
    202. The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen. Cell. 1998 Dec 23; 95(7):927-37. Shiau AK, Barstad D, Loria PM, Cheng L, Kushner PJ, Agard DA, Greene GL. PMID: 9875847.
      View in: PubMed   Mentions: 611     Fields:    Translation:HumansAnimalsCells
    203. Structure of alpha-lytic protease complexed with its pro region. Nat Struct Biol. 1998 Nov; 5(11):945-50. Sauter NK, Mau T, Rader SD, Agard DA. PMID: 9808037.
      View in: PubMed   Mentions: 30     Fields:    Translation:Cells
    204. Unfolded conformations of alpha-lytic protease are more stable than its native state. Nature. 1998 Oct 22; 395(6704):817-9. Sohl JL, Jaswal SS, Agard DA. PMID: 9796818.
      View in: PubMed   Mentions: 59     Fields:    Translation:Cells
    205. Pro region C-terminus:protease active site interactions are critical in catalyzing the folding of alpha-lytic protease. Biochemistry. 1998 Sep 01; 37(35):12058-67. Peters RJ, Shiau AK, Sohl JL, Anderson DE, Tang G, Silen JL, Agard DA. PMID: 9724517.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    206. Relationship between enzyme specificity and the backbone dynamics of free and inhibited alpha-lytic protease. Biochemistry. 1998 May 26; 37(21):7696-707. Davis JH, Agard DA. PMID: 9601029.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    207. Homologous chromosome pairing in Drosophila melanogaster proceeds through multiple independent initiations. J Cell Biol. 1998 Apr 06; 141(1):5-20. Fung JC, Marshall WF, Dernburg A, Agard DA, Sedat JW. PMID: 9531544; PMCID: PMC2132734.
      View in: PubMed   Mentions: 112     Fields:    Translation:AnimalsCells
    208. Activation of a retroviral membrane fusion protein: soluble receptor-induced liposome binding of the ALSV envelope glycoprotein. J Cell Biol. 1997 Dec 15; 139(6):1455-64. Hernandez LD, Peters RJ, Delos SE, Young JA, Agard DA, White JM. PMID: 9396751; PMCID: PMC2132611.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    209. Interphase chromosomes undergo constrained diffusional motion in living cells. Curr Biol. 1997 Dec 01; 7(12):930-9. Marshall WF, Straight A, Marko JF, Swedlow J, Dernburg A, Belmont A, Murray AW, Agard DA, Sedat JW. PMID: 9382846.
      View in: PubMed   Mentions: 265     Fields:    Translation:AnimalsCells
    210. Practical image restoration of thick biological specimens using multiple focus levels in transmission electron microscopy. J Struct Biol. 1997 Dec; 120(3):237-44. Han KF, Sedat JW, Agard DA. PMID: 9441929.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    211. Alterations in chemical shifts and exchange broadening upon peptide boronic acid inhibitor binding to alpha-lytic protease. J Biomol NMR. 1997 Jul; 10(1):21-7. Davis JH, Agard DA, Handel TM, Basus VJ. PMID: 9335113.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    212. Conformational substates in enzyme mechanism: the 120 K structure of alpha-lytic protease at 1.5 A resolution. Protein Sci. 1997 Jul; 6(7):1375-86. Rader SD, Agard DA. PMID: 9232638; PMCID: PMC2143753.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    213. Telomeres cluster de novo before the initiation of synapsis: a three-dimensional spatial analysis of telomere positions before and during meiotic prophase. J Cell Biol. 1997 Apr 07; 137(1):5-18. Bass HW, Marshall WF, Sedat JW, Agard DA, Cande WZ. PMID: 9105032; PMCID: PMC2139864.
      View in: PubMed   Mentions: 100     Fields:    Translation:AnimalsCells
    214. Inhibition of alpha-lytic protease by pro region C-terminal steric occlusion of the active site. Biochemistry. 1997 Apr 01; 36(13):3894-902. Sohl JL, Shiau AK, Rader SD, Wilk BJ, Agard DA. PMID: 9092819.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    215. Optimal strategies for imaging thick biological specimens: exit wavefront reconstruction and energy-filtered imaging. J Microsc. 1996 Aug; 183(Pt 2):124-32. Han KF, Gubbens AJ, Sedat JW, Agard DA. PMID: 8805824.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    216. Perturbation of nuclear architecture by long-distance chromosome interactions. Cell. 1996 May 31; 85(5):745-59. Dernburg AF, Broman KW, Fung JC, Marshall WF, Philips J, Agard DA, Sedat JW. PMID: 8646782.
      View in: PubMed   Mentions: 140     Fields:    Translation:AnimalsCells
    217. Specific interactions of chromatin with the nuclear envelope: positional determination within the nucleus in Drosophila melanogaster. Mol Biol Cell. 1996 May; 7(5):825-42. Marshall WF, Dernburg AF, Harmon B, Agard DA, Sedat JW. PMID: 8744953; PMCID: PMC275932.
      View in: PubMed   Mentions: 79     Fields:    Translation:AnimalsCells
    218. Dispersion, aberration and deconvolution in multi-wavelength fluorescence images. J Microsc. 1996 Apr; 182(Pt 1):50-60. Scalettar BA, Swedlow JR, Sedat JW, Agard DA. PMID: 8632447.
      View in: PubMed   Mentions: 27     Fields:    
    219. Time-resolved, in vivo studies of mitotic spindle formation and nuclear lamina breakdown in Drosophila early embryos. J Cell Sci. 1996 Mar; 109 ( Pt 3):591-607. Paddy MR, Saumweber H, Agard DA, Sedat JW. PMID: 8907705.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    220. IVE (Image Visualization Environment): a software platform for all three-dimensional microscopy applications. J Struct Biol. 1996 Jan-Feb; 116(1):56-60. Chen H, Hughes DD, Chan TA, Sedat JW, Agard DA. PMID: 8742723.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    221. Toward fully automated high-resolution electron tomography. J Struct Biol. 1996 Jan-Feb; 116(1):181-9. Fung JC, Liu W, de Ruijter WJ, Chen H, Abbey CK, Sedat JW, Agard DA. PMID: 8742742.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    222. Kinetic and structural characterization of mutations of glycine 216 in alpha-lytic protease: a new target for engineering substrate specificity. J Mol Biol. 1995 Dec 08; 254(4):720-36. Mace JE, Agard DA. PMID: 7500345.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    223. Microtubule nucleation by gamma-tubulin-containing rings in the centrosome. Nature. 1995 Dec 07; 378(6557):638-40. Moritz M, Braunfeld MB, Sedat JW, Alberts B, Agard DA. PMID: 8524401.
      View in: PubMed   Mentions: 179     Fields:    Translation:AnimalsCells
    224. A three-dimensional structural dissection of Drosophila polytene chromosomes. J Cell Biol. 1995 Oct; 131(2):279-95. Urata Y, Parmelee SJ, Agard DA, Sedat JW. PMID: 7593159; PMCID: PMC2199990.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    225. Three-dimensional structural characterization of centrosomes from early Drosophila embryos. J Cell Biol. 1995 Sep; 130(5):1149-59. Moritz M, Braunfeld MB, Fung JC, Sedat JW, Alberts BM, Agard DA. PMID: 7657699; PMCID: PMC2120545.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    226. Functional linkage between the active site of alpha-lytic protease and distant regions of structure: scanning alanine mutagenesis of a surface loop affects activity and substrate specificity. J Mol Biol. 1995 Aug 04; 251(1):116-34. Mace JE, Wilk BJ, Agard DA. PMID: 7643381.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    227. Mechanism of image formation for thick biological specimens: exit wavefront reconstruction and electron energy-loss spectroscopic imaging. J Microsc. 1995 May; 178(Pt 2):107-19. Han KF, Sedat JW, Agard DA. PMID: 7783184.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    228. Influenza hemagglutinin: kinetic control of protein function. Structure. 1994 Oct 15; 2(10):907-10. Baker D, Agard DA. PMID: 7866741.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    229. Human apolipoprotein E. Role of arginine 61 in mediating the lipoprotein preferences of the E3 and E4 isoforms. J Biol Chem. 1994 Sep 02; 269(35):22358-65. Dong LM, Wilson C, Wardell MR, Simmons T, Mahley RW, Weisgraber KH, Agard DA. PMID: 8071364.
      View in: PubMed   Mentions: 111     Fields:    Translation:HumansAnimalsCells
    230. Salt bridge relay triggers defective LDL receptor binding by a mutant apolipoprotein. Structure. 1994 Aug 15; 2(8):713-8. Wilson C, Mau T, Weisgraber KH, Wardell MR, Mahley RW, Agard DA. PMID: 7994571.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    231. Kinetics versus thermodynamics in protein folding. Biochemistry. 1994 Jun 21; 33(24):7505-9. Baker D, Agard DA. PMID: 8011615.
      View in: PubMed   Mentions: 61     Fields:    Translation:Cells
    232. Cryo automated electron tomography: towards high-resolution reconstructions of plastic-embedded structures. J Microsc. 1994 May; 174(Pt 2):75-84. Braunfeld MB, Koster AJ, Sedat JW, Agard DA. PMID: 8051698.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    233. The three-dimensional architecture of chromatin in situ: electron tomography reveals fibers composed of a continuously variable zig-zag nucleosomal ribbon. J Cell Biol. 1994 Apr; 125(1):1-10. Horowitz RA, Agard DA, Sedat JW, Woodcock CL. PMID: 8138564; PMCID: PMC2120010.
      View in: PubMed   Mentions: 71     Fields:    Translation:AnimalsCells
    234. Meiotic chromosome pairing in maize is associated with a novel chromatin organization. Cell. 1994 Mar 11; 76(5):901-12. Dawe RK, Sedat JW, Agard DA, Cande WZ. PMID: 8124724.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    235. The role of pro regions in protein folding. Curr Opin Cell Biol. 1993 Dec; 5(6):966-70. Baker D, Shiau AK, Agard DA. PMID: 8129949.
      View in: PubMed   Mentions: 41     Fields:    Translation:Cells
    236. PRISM: application to the solution of two protein structures. Acta Crystallogr D Biol Crystallogr. 1993 Sep 01; 49(Pt 5):440-8. Bystroff C, Baker D, Fletterick RJ, Agard DA. PMID: 15299503.
      View in: PubMed   Mentions: 2     Fields:    
    237. PRISM: topologically constrained phased refinement for macromolecular crystallography. Acta Crystallogr D Biol Crystallogr. 1993 Sep 01; 49(Pt 5):429-39. Baker D, Bystroff C, Fletterick RJ, Agard DA. PMID: 15299502.
      View in: PubMed   Mentions: 9     Fields:    
    238. To fold or not to fold.... Science. 1993 Jun 25; 260(5116):1903-4. Agard DA. PMID: 8100365.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    239. Chromosome structure inside the nucleus. Curr Opin Cell Biol. 1993 Jun; 5(3):412-6. Swedlow JR, Agard DA, Sedat JW. PMID: 8352957.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    240. Multiple chromosomal populations of topoisomerase II detected in vivo by time-lapse, three-dimensional wide-field microscopy. Cell. 1993 Apr 09; 73(1):97-108. Swedlow JR, Sedat JW, Agard DA. PMID: 8384932.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    241. Modeling side-chain conformation for homologous proteins using an energy-based rotamer search. J Mol Biol. 1993 Feb 20; 229(4):996-1006. Wilson C, Gregoret LM, Agard DA. PMID: 8445659.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    242. The onset of homologous chromosome pairing during Drosophila melanogaster embryogenesis. J Cell Biol. 1993 Feb; 120(3):591-600. Hiraoka Y, Dernburg AF, Parmelee SJ, Rykowski MC, Agard DA, Sedat JW. PMID: 8425892; PMCID: PMC2119536.
      View in: PubMed   Mentions: 88     Fields:    Translation:AnimalsCells
    243. Uniqueness and the ab initio phase problem in macromolecular crystallography. Acta Crystallogr D Biol Crystallogr. 1993 Jan 01; 49(Pt 1):186-92. Baker D, Krukowski AE, Agard DA. PMID: 15299560.
      View in: PubMed   Mentions: 9     Fields:    
    244. Automated microscopy for electron tomography. Ultramicroscopy. 1992 Oct; 46(1-4):207-27. Koster AJ, Chen H, Sedat JW, Agard DA. PMID: 1481272.
      View in: PubMed   Mentions: 32     Fields:    Translation:Cells
    245. An extended view of nuclear lamin structure, function, and dynamics. Semin Cell Biol. 1992 Aug; 3(4):255-66. Paddy MR, Agard DA, Sedat JW. PMID: 1421171.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    246. Correct folding of alpha-lytic protease is required for its extracellular secretion from Escherichia coli. J Cell Biol. 1992 Jul; 118(1):33-42. Fujishige A, Smith KR, Silen JL, Agard DA. PMID: 1618906; PMCID: PMC2289522.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    247. Protease pro region required for folding is a potent inhibitor of the mature enzyme. Proteins. 1992 Apr; 12(4):339-44. Baker D, Silen JL, Agard DA. PMID: 1579568.
      View in: PubMed   Mentions: 27     Fields:    Translation:Cells
    248. A protein-folding reaction under kinetic control. Nature. 1992 Mar 19; 356(6366):263-5. Baker D, Sohl JL, Agard DA. PMID: 1552947.
      View in: PubMed   Mentions: 59     Fields:    Translation:Cells
    249. Structural basis for broad specificity in alpha-lytic protease mutants. Biochemistry. 1991 Oct 29; 30(43):10388-98. Bone R, Fujishige A, Kettner CA, Agard DA. PMID: 1931963.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    250. Computational method for the design of enzymes with altered substrate specificity. J Mol Biol. 1991 Jul 20; 220(2):495-506. Wilson C, Mace JE, Agard DA. PMID: 1856870.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    251. Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E. Science. 1991 Jun 28; 252(5014):1817-22. Wilson C, Wardell MR, Weisgraber KH, Mahley RW, Agard DA. PMID: 2063194.
      View in: PubMed   Mentions: 207     Fields:    Translation:HumansCells
    252. Drosophila gastrulation: analysis of cell shape changes in living embryos by three-dimensional fluorescence microscopy. Development. 1991 Jun; 112(2):365-70. Kam Z, Minden JS, Agard DA, Sedat JW, Leptin M. PMID: 1794308.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    253. Three-dimensional multiple-wavelength fluorescence microscopy for the structural analysis of biological phenomena. Semin Cell Biol. 1991 Jun; 2(3):153-65. Hiraoka Y, Swedlow JR, Paddy MR, Agard DA, Sedat JW. PMID: 1720334.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    254. Crystal structures of alpha-lytic protease complexes with irreversibly bound phosphonate esters. Biochemistry. 1991 Feb 26; 30(8):2263-72. Bone R, Sampson NS, Bartlett PA, Agard DA. PMID: 1998685.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    255. Free energy calculations on binding and catalysis by alpha-lytic protease: the role of substrate size in the P1 pocket. Proteins. 1991; 10(2):140-8. Caldwell JW, Agard DA, Kollman PA. PMID: 1896427.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    256. Mutational remodeling of enzyme specificity. Methods Enzymol. 1991; 202:643-71. Bone R, Agard DA. PMID: 1784192.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    257. Temporal and spatial coordination of chromosome movement, spindle formation, and nuclear envelope breakdown during prometaphase in Drosophila melanogaster embryos. J Cell Biol. 1990 Dec; 111(6 Pt 2):2815-28. Hiraoka Y, Agard DA, Sedat JW. PMID: 2125300; PMCID: PMC2116368.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    258. Interphase nuclear envelope lamins form a discontinuous network that interacts with only a fraction of the chromatin in the nuclear periphery. Cell. 1990 Jul 13; 62(1):89-106. Paddy MR, Belmont AS, Saumweber H, Agard DA, Sedat JW. PMID: 2194675.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    259. Determination of three-dimensional imaging properties of a light microscope system. Partial confocal behavior in epifluorescence microscopy. Biophys J. 1990 Feb; 57(2):325-33. Hiraoka Y, Sedat JW, Agard DA. PMID: 2317554; PMCID: PMC1280673.
      View in: PubMed   Mentions: 79     Fields:    
    260. Focal points for chromosome condensation and decondensation revealed by three-dimensional in vivo time-lapse microscopy. Nature. 1989 Nov 16; 342(6247):293-6. Hiraoka Y, Minden JS, Swedlow JR, Sedat JW, Agard DA. PMID: 2509947.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    261. The alpha-lytic protease pro-region does not require a physical linkage to activate the protease domain in vivo. Nature. 1989 Oct 05; 341(6241):462-4. Silen JL, Agard DA. PMID: 2507926.
      View in: PubMed   Mentions: 51     Fields:    Translation:Cells
    262. Structural analysis of specificity: alpha-lytic protease complexes with analogues of reaction intermediates. Biochemistry. 1989 Sep 19; 28(19):7600-9. Bone R, Frank D, Kettner CA, Agard DA. PMID: 2611204.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    263. Large-scale chromatin structural domains within mitotic and interphase chromosomes in vivo and in vitro. Chromosoma. 1989 Aug; 98(2):129-43. Belmont AS, Braunfeld MB, Sedat JW, Agard DA. PMID: 2476279.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    264. Direct cell lineage analysis in Drosophila melanogaster by time-lapse, three-dimensional optical microscopy of living embryos. J Cell Biol. 1989 Aug; 109(2):505-16. Minden JS, Agard DA, Sedat JW, Alberts BM. PMID: 2503522; PMCID: PMC2115721.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    265. Structural plasticity broadens the specificity of an engineered protease. Nature. 1989 May 18; 339(6221):191-5. Bone R, Silen JL, Agard DA. PMID: 2716847.
      View in: PubMed   Mentions: 34     Fields:    Translation:Cells
    266. Analysis of prepro-alpha-lytic protease expression in Escherichia coli reveals that the pro region is required for activity. J Bacteriol. 1989 Mar; 171(3):1320-5. Silen JL, Frank D, Fujishige A, Bone R, Agard DA. PMID: 2646278; PMCID: PMC209748.
      View in: PubMed   Mentions: 41     Fields:    Translation:Cells
    267. Fluorescence microscopy in three dimensions. Methods Cell Biol. 1989; 30:353-77. Agard DA, Hiraoka Y, Shaw P, Sedat JW. PMID: 2494418.
      View in: PubMed   Mentions: 158     Fields:    Translation:AnimalsCells
    268. Tilted view reconstruction in optical microscopy. Three-dimensional reconstruction of Drosophila melanogaster embryo nuclei. Biophys J. 1989 Jan; 55(1):101-10. Shaw PJ, Agard DA, Hiraoka Y, Sedat JW. PMID: 2495031; PMCID: PMC1330446.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    269. Solid-state imagers for microscopy. Methods Cell Biol. 1989; 29:291-313. Aikens RS, Agard DA, Sedat JW. PMID: 2643764.
      View in: PubMed   Mentions: 15     Fields:    
    270. Kinetic properties of the binding of alpha-lytic protease to peptide boronic acids. Biochemistry. 1988 Oct 04; 27(20):7682-8. Kettner CA, Bone R, Agard DA, Bachovchin WW. PMID: 3207699.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    271. Molecular analysis of the gene encoding alpha-lytic protease: evidence for a preproenzyme. Gene. 1988 Sep 30; 69(2):237-44. Silen JL, McGrath CN, Smith KR, Agard DA. PMID: 3234766.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    272. Precise determination of the molecular limits of a polytene chromosome band: regulatory sequences for the Notch gene are in the interband. Cell. 1988 Aug 12; 54(4):461-72. Rykowski MC, Parmelee SJ, Agard DA, Sedat JW. PMID: 3135939.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    273. Crystallization and preliminary X-ray diffraction studies on the amino-terminal (receptor-binding) domain of human apolipoprotein E3 from serum very low density lipoproteins. J Mol Biol. 1988 Jul 05; 202(1):179-81. Aggerbeck LP, Wetterau JR, Weisgraber KH, Mahley RW, Agard DA. PMID: 3172212.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    274. Three-dimensional light microscopy of diploid Drosophila chromosomes. Cell Motil Cytoskeleton. 1988; 10(1-2):18-27. Agard DA, Hiraoka Y, Sedat JW. PMID: 3141069.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    275. Serine protease mechanism: structure of an inhibitory complex of alpha-lytic protease and a tightly bound peptide boronic acid. Biochemistry. 1987 Dec 01; 26(24):7609-14. Bone R, Shenvi AB, Kettner CA, Agard DA. PMID: 3122831.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    276. The use of a charge-coupled device for quantitative optical microscopy of biological structures. Science. 1987 Oct 02; 238(4823):36-41. Hiraoka Y, Sedat JW, Agard DA. PMID: 3116667.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    277. [Hepatonephritis caused by piroxicam]. Gastroenterol Clin Biol. 1987 Oct; 11(10):712-3. Marsepoil T, Levesque P, Agard D, Dubeaux P, Blin F. PMID: 3692097.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    278. A three-dimensional approach to mitotic chromosome structure: evidence for a complex hierarchical organization. J Cell Biol. 1987 Jul; 105(1):77-92. Belmont AS, Sedat JW, Agard DA. PMID: 3112167; PMCID: PMC2114920.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    279. Quantitative analysis of nucleic acids, proteins, and viruses by Raman band deconvolution. Biophys J. 1984 Dec; 46(6):763-8. Thomas GJ, Agard DA. PMID: 6083811; PMCID: PMC1435106.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    280. [Anorectal manifestations of sexually transmissible diseases. Kaposi's sarcoma]. Ann Gastroenterol Hepatol (Paris). 1984 Oct-Nov; 20(5):265-70. Libeskind M, Malbran J, Agard D, Pannetier C, Lecouillard C, Ivanovic A. PMID: 6549375.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    281. Optical sectioning microscopy: cellular architecture in three dimensions. Annu Rev Biophys Bioeng. 1984; 13:191-219. Agard DA. PMID: 6742801.
      View in: PubMed   Mentions: 75     Fields:    Translation:AnimalsCells
    282. Spatial organization of the Drosophila nucleus: a three-dimensional cytogenetic study. J Cell Sci Suppl. 1984; 1:223-34. Gruenbaum Y, Hochstrasser M, Mathog D, Saumweber H, Agard DA, Sedat JW. PMID: 6442295.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    283. A least-squares method for determining structure factors in three-dimensional tilted-view reconstructions. J Mol Biol. 1983 Jul 15; 167(4):849-52. Agard DA. PMID: 6876167.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    284. Three-dimensional architecture of a polytene nucleus. Nature. 1983 Apr 21; 302(5910):676-81. Agard DA, Sedat JW. PMID: 6403872.
      View in: PubMed   Mentions: 92     Fields:    Translation:AnimalsCells
    285. [Syndrome of inappropriate antidiuretic hormone secretion. A report of two cases with hyponatremia and hypouricemia]. Sem Hop. 1982 Sep 23; 58(34):1925-7. Malbran J, Agard D, Libeskind M, Redelsperger PY, Lecouillard C, Pannetier C. PMID: 6293074.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    286. Linking regions between helices in bacteriorhodopsin revealed. Biophys J. 1982 Mar; 37(3):589-602. Agard DA, Stroud RM. PMID: 7074187; PMCID: PMC1328844.
      View in: PubMed   Mentions: 24     Fields:    
    287. Studies on the phosphorylation and synthesis of type I regulatory subunit of cyclic AMP-dependent protein kinase in intact S49 mouse lymphoma cells. J Biol Chem. 1981 Nov 10; 256(21):11356-64. Steinberg RA, Agard DA. PMID: 6270151.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    288. Turnover of regulatory subunit of cyclic AMP-dependent protein kinase in S49 mouse lymphoma cells. Regulation by catalytic subunit and analogs of cyclic AMP. J Biol Chem. 1981 Nov 10; 256(21):10731-4. Steinberg RA, Agard DA. PMID: 6270127.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    289. Quantitative analysis of electrophoretograms: a mathematical approach to super-resolution. Anal Biochem. 1981 Mar 01; 111(2):257-68. Agard DA, Steinberg RA, Stroud RM. PMID: 7247021.
      View in: PubMed   Mentions: 7     Fields:    
    290. [Hemorrhoids. Physiopathogenic concepts and approach to a rational treatment]. Gastroenterol Clin Biol. 1979 Oct; 3(10):705-8. Libeskind M, Lugagne F, Malbran J, Agard D, Redelsperger PY. PMID: 527779.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    291. Structure determination of asymmetric membrane profiles using an iterative Fourier method. Biophys J. 1979 Mar; 25(3):495-512. Stroud RM, Agard DA. PMID: 318062; PMCID: PMC1328487.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    292. [Gastrointestinal haemorrhage in the cirrhotic. The value of injectable posterior pituitary extract (author's transl)]. Nouv Presse Med. 1978 May 06; 7(18):1537-40. Libeskind M, Malbran J, Lugagne F, Redelsperger PY, Bourgeois J, Agard D. PMID: 307734.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    293. [The excision of villous tumours of the rectum via a trans-sphincterian anal approach (author's transl)]. Nouv Presse Med. 1978 Mar 18; 7(11):935-6. Libeskind M, Lugagne F, Malbran J, Agard D, Redelsperger PY. PMID: 643560.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    294. [Secondary melanomas of the liver. Appropos of 3 cases with hepatic symptomatology]. Med Chir Dig. 1978; 7(4):315-8. Libeskind M, Redelsperger PY, Lugagne F, Malbran J, Agard D. PMID: 672278.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    295. Structural studies of a membrane-bound acetylcholine receptor from Torpedo californica. J Mol Biol. 1977 Nov; 116(4):635-59. Ross MJ, Klymkowsky MW, Agard DA, Stroud RM. PMID: 563472.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    296. [Systemic amyloidosis and multiple myeloma. Report of a case with the association of light chain myeloma and gastric plasmacytosis (author's transl)]. Gastroenterol Clin Biol. 1977 Mar; 1(3):267-74. Libeskind M, Malbran J, Lugagne F, Agard D, Gatineau-Saillant C, Guyet-Rousset P. PMID: 408215.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    With one click, see people who:

    Mentor Faculty

    Run Clinical Trials

    Work in Global Health Equity

    Offer Student Projects

    See more options in the Advanced Search tab

    David's Networks
    Concepts (802)
    Derived automatically from this person's publications.
    Explore
    _
    Co-Authors (118)
    People in Profiles who have published with this person.
    Explore
    _
    Similar People (60)
    People who share similar concepts with this person.
    Explore
    _
    Same Department
    Search Department
    _

    UCSF Profiles is managed by the UCSF Clinical and Translational Science Institute (CTSI), part of the Clinical and Translational Science Award program funded by the National Center for Advancing Translational Sciences (Grant Number UL1 TR000004) at the National Institutes of Health (NIH).

    We use cookies to operate our website. We also use cookies to analyze our site’s performance and improve your experience on our site. For more information about how we use cookies, please see our Website Terms of Use. This site is running Profiles RNS version UCSF-v3.1.0-3-g1ef1264b on PROFILES-PWEB04.

    Copyright © The Regents of the University of California.