David Erle, MD
|School||UCSF School of Medicine|
|Address||1550 4th St., Mission Bay|
Dr. Erle received an A.B. degree (Biochemistry) from Harvard College in 1980 and an M.D. degree from UCSF in 1984. He was trained in internal medicine and in pulmonary disease at UCSF. As a CVRI research fellow training at the UCSF Lung Biology Center, he studied leukocyte integrins with Robert Pytela and Dean Sheppard. He joined the Lung Biology Center faculty in 1990. His academic activities include laboratory research and clinical teaching. He is the Director of the Functional Genomics Core Facility, UCSF Sandler Center for Basic Research in Asthma. He is a member of the UCSF Program in Immunology and the Cardiovascular Research Institute. He serves as an Attending Physician in the San Francisco General Hospital Medical ICU and the Pulmonary Consultation Service.
Asthma: role of airway epithelial cells. The airway epithelium is increasingly recognized as a key participant in asthma and other major lung diseases. Our group has developed models to understand how IL-13 and other cytokines produced during airway inflammation act on epithelial cells to produce disease. Ongoing work is investigating how specialized molecules in the endoplasmic reticulum contribute to mucus overproduction in asthma and how micro-RNAs affect airway epithelial cell differentiation and function.
Functional genomics. Powerful genomics tools such as next generation sequencing and microarrays offer new opportunities for understanding lung biology and disease. Members of our group have extensive experience with these technologies. Projects within the lab and collaborative projects with many investigators at UCSF and beyond are using these technologies to investigate pulmonary cell biology, mouse disease models, and samples from humans with asthma and other diseases. We are also pursuing novel genomics approaches, including development of a system for high-throughput analysis of the function of sequences from 3’ untranslated regions of mRNAs.
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