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David Hwang, MD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentOphthalmology
Address10 Koret Way
San Francisco CA 94143
Phone415-476-3705
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    Collapse Biography 
    Collapse education and training
    USC/Doheny Eye InstituteFellowship - Cornea, External Disease, and Refractive Surgery1990School of Medicine
    USC/Doheny Eye InstituteFellowship - Uveitis1990School of Medicine
    University of California, San FranciscoResidency - Ophthalmology1989School of Medicine
    University of California, San FranciscoResidency - Internal Medicine1986School of Medicine
    University of California, San FranciscoM.D.1984 School of Medicine

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    Collapse overview
    A native of Illinois, USA, David G. Hwang, MD, FACS obtained both his undergraduate and medical degrees from the University of California, San Francisco (UCSF), graduating first in his medical school class in 1984. After two years of internal medical residency and three years of ophthalmology residency at UCSF, he completed concurrent fellowships in cornea and refractive surgery as well as uveitis at the University of Southern California/Doheny Eye Institute as a Heed Fellow. In 1990 he joined the full-time faculty at the University of California, San Francisco, where he is currently Professor and Vice Chair and holds the Pearl T. Kimura and Samuel J. Kimura Endowed Chair in Ophthalmology. He serves as Co-Director of the Cornea Service and the Refractive Surgery Service and holds a joint appointment as Associate of the Francis I. Proctor Foundation at UCSF.

    Dr. Hwang has served in leadership and executive roles in a number of professional organizations, including President of the Ocular Microbiology and Immunology Group, Executive Secretary of the Max Fine Cornea Society, Medical Director of Ophthalmology at the UCSF Medical Center, and Medical Eye Bank Director of the UCSF Tissue Bank. He has chaired the joint American Academy of Ophthalmology (AAO)-Centers for Disease Control Task Force for the Use of Vancomycin in Ophthalmology and has served on the writing committee for the Cornea and External Disease volume of the AAO Basic and Clinical Science series, in which he was responsible for authoring and editing the section on ocular infectious and external eye disease.

    A committed educator, Dr. Hwang is active in the teaching of students, residents, and fellows and has received the Kimura Award for Excellence in Teaching from the UCSF Department of Ophthalmology. He has organized and taught numerous postgraduate courses and conferences at the regional, national, and international level and is a frequently invited speaker at national and international meetings. He has been the recipient of several named lectureships, been awarded the Honor Award and Senior Achievement Award from the American Academy of Ophthalmology, and been named to the “Best Doctors in the United States” list every year since 1996.

    Dr. Hwang’s university-based referral practice is focused on corneal, cataract, and refractive surgery, with special interests in ocular infectious disease, corneal endothelial dystrophies and diseases, and high-risk corneal transplantation. He has conducted translational research into cellular transplantation and gene therapy approaches to corneal endothelial disease. He described the relationship between inadequate dosing of topical fluoroquinolones and subsequent antimicrobial resistance, and he reported the pharmacodynamic and genomic mechanisms underlying such development. As a result of his investigations, Dr. Hwang widely advocated for changing prevailing antimicrobial prescribing patterns away from prolonged, intermittent, and/or tapering dosing towards short-term, suprathreshold dosing.

    His clinical interests include the development of innovative surgical techniques and instrumentation in corneal, cataract, and refractive surgery. He has published over 100 original articles and scientific abstracts and has co-authored two texts in cornea and refractive surgery. He resides in the San Francisco Bay Area with his wife, an ophthalmologist, and their three sons.


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    Collapse Selected Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Seider MI, Hwang DG, Damato BE. Peculiar protuberance. JAMA Ophthalmol. 2014 Dec; 132(12):1483-4. PMID: 25501400.
      View in: PubMed
    2. Fintelmann RE, Kim SK, Hwang DG. Upside-down lens syndrome: ocular complications secondary to inverted implantation of the Kelman Multiflex anterior chamber intraocular lens. Am J Ophthalmol. 2011 Jul; 152(1):122-125.e2. PMID: 21570051.
      View in: PubMed
    3. Stewart WC, Crean CS, Zink RC, Brubaker K, Haque RM, Hwang DG. Pharmacokinetics of azithromycin and moxifloxacin in human conjunctiva and aqueous humor during and after the approved dosing regimens. Am J Ophthalmol. 2010 Nov; 150(5):744-751.e2. PMID: 20813346.
      View in: PubMed
    4. Rutar T, Hwang DG, Stamper RL. Acute angle-closure glaucoma due to iris transfixation of a subluxated posterior chamber intraocular lens-capsular bag complex. J Cataract Refract Surg. 2007 Sep; 33(9):1662-3. PMID: 17720091.
      View in: PubMed
    5. Bernal MD, Acharya NR, Lietman TM, Strauss EC, McLeod SD, Hwang DG. Outbreak of Fusarium keratitis in soft contact lens wearers in San Francisco. Arch Ophthalmol. 2006 Jul; 124(7):1051-3. PMID: 16769826.
      View in: PubMed
    6. Magone MT, Maric I, Hwang DG. Peripheral interstitial keratitis: a novel manifestation of ocular mastocytosis. Cornea. 2006 Apr; 25(3):364-7. PMID: 16633043.
      View in: PubMed
    7. Naseri A, Forseto AS, Francesconi CM, Hwang DG, Campos M, Nose W. Comparison of topographic corneal irregularity after LASIK and intrastromal corneal ring segments in the same patients. J Refract Surg. 2005 Nov-Dec; 21(6):722-6. PMID: 16329365.
      View in: PubMed
    8. Hsiao CH, Sah WJ, Soya K, Ma DH, Im YW, Zhang F, Hwang DG. Effects of SV40 T antigen transduction on human corneal endothelial cell wound healing in vitro. J Ocul Pharmacol Ther. 2005 Oct; 21(5):353-66. PMID: 16245961.
      View in: PubMed
    9. Sugioka K, Drake JD, Fukuda M, Shimomura Y, Hwang DG. Susceptibility of human corneal endothelial cells to HSV-1 infection. Curr Eye Res. 2005 Oct; 30(10):863-9. PMID: 16251123.
      View in: PubMed
    10. McLeod SD, Mather R, Hwang DG, Margolis TP. Uveitis-associated flap edema and lamellar interface fluid collection after LASIK. Am J Ophthalmol. 2005 Jun; 139(6):1137-9. PMID: 15953462.
      View in: PubMed
    11. Cheung MC, Nune GC, Hwang DG, Sutter EE, Duncan JL. Acute zonal occult outer retinopathy in a patient with graft-versus-host disease. Am J Ophthalmol. 2004 Dec; 138(6):1058-60. PMID: 15629309.
      View in: PubMed
    12. Kuo IC, Lee SM, Hwang DG. Late-onset corneal haze and myopic regression after photorefractive keratectomy (PRK). Cornea. 2004 May; 23(4):350-5. PMID: 15097128.
      View in: PubMed
    13. Jeng BH, Stewart JM, McLeod SD, Hwang DG. Relapsing diffuse lamellar keratitis after laser in situ keratomileusis associated with recurrent erosion syndrome. Arch Ophthalmol. 2004 Mar; 122(3):396-8. PMID: 15006861.
      View in: PubMed
    14. Hwang DG. Fluoroquinolone resistance in ophthalmology and the potential role for newer ophthalmic fluoroquinolones. Surv Ophthalmol. 2004 Mar; 49 Suppl 2:S79-83. PMID: 15028483.
      View in: PubMed
    15. Aldave AJ, Yellore VS, Hwang DG. Atypical vortex pattern of corneal deposits in granular corneal dystrophy. Cornea. 2003 Nov; 22(8):754-9. PMID: 14576527.
      View in: PubMed
    16. Ma DH, Chen JI, Zhang F, Hwang DG, Chen JK. Inhibition of fibroblast-induced angiogenic phenotype of cultured endothelial cells by the overexpression of tissue inhibitor of metalloproteinase (TIMP)-3. J Biomed Sci. 2003 Sep-Oct; 10(5):526-34. PMID: 12928593.
      View in: PubMed
    17. McLeod SD, Tham VM, Phan ST, Hwang DG, Rizen M, Abbott RL. Bilateral diffuse lamellar keratitis following bilateral simultaneous versus sequential laser in situ keratomileusis. Br J Ophthalmol. 2003 Sep; 87(9):1086-7. PMID: 12928271; PMCID: PMC1771840.
    18. Hwang DG, Schanzlin DJ, Rotberg MH, Foulks G, Raizman MB. A phase III, placebo controlled clinical trial of 0.5% levofloxacin ophthalmic solution for the treatment of bacterial conjunctivitis. Br J Ophthalmol. 2003 Aug; 87(8):1004-9. PMID: 12881345; PMCID: PMC1771798.
    19. Ma DH, Zhang F, Shi W, Yao JY, Hsiao CH, Wu HC, Kim WS, Hao YX, Hwang DG, Chen JK, Tsai RJ. Expression of tissue inhibitor of metalloproteinase-4 in normal human corneal cells and experimental corneal neovascularization. Ophthalmic Res. 2003 Jul-Aug; 35(4):199-207. PMID: 12815195.
      View in: PubMed
    20. Iwata M, Soya K, Sawa M, Sakimoto T, Hwang DG. CD40 expression in normal human cornea and regulation of CD40 in cultured human corneal epithelial and stromal cells. Invest Ophthalmol Vis Sci. 2002 Feb; 43(2):348-57. PMID: 11818376.
      View in: PubMed
    21. Ma DH, Chen JK, Kim WS, Hao YX, Wu HC, Tsai RJ, Hwang DG, Zhang F. Expression of matrix metalloproteinases 2 and 9 and tissue inhibitors of metalloproteinase 1 and 2 in inflammation-induced corneal neovascularization. Ophthalmic Res. 2001 Nov-Dec; 33(6):353-62. PMID: 11721189.
      View in: PubMed
    22. van de Pol C, Soya K, Hwang DG. Objective assessment of transient corneal haze and its relation to visual performance after photorefractive keratectomy. Am J Ophthalmol. 2001 Aug; 132(2):204-10. PMID: 11476680.
      View in: PubMed
    23. Tham VM, Hwang DG. The intrastromal corneal ring segments: Intacs. Ophthalmol Clin North Am. 2001 Jun; 14(2):295-9, viii. PMID: 11406425.
      View in: PubMed
    24. Tachibana A, Sawa M, Hwang DG. [Development of corneal storage medium--second report. Examination of human cornea]. Nippon Ganka Gakkai Zasshi. 2001 May; 105(5):295-300. PMID: 11406944.
      View in: PubMed
    25. Graves A, Henry M, O'Brien TP, Hwang DG, Van Buskirk A, Trousdale MD. In vitro susceptibilities of bacterial ocular isolates to fluoroquinolones. Cornea. 2001 Apr; 20(3):301-5. PMID: 11322420.
      View in: PubMed
    26. Kuo IC, Margolis TP, Cevallos V, Hwang DG. Aspergillus fumigatus keratitis after laser in situ keratomileusis. Cornea. 2001 Apr; 20(3):342-4. PMID: 11322429.
      View in: PubMed
    27. Kuo IC, Ou R, Hwang DG. Flap haze after epithelial debridement and flap hydration for treatment of post-laser in situ keratomileusis striae. Cornea. 2001 Apr; 20(3):339-41. PMID: 11322428.
      View in: PubMed
    28. Hao Y, Ma DH, Hwang DG, Kim WS, Zhang F. Identification of antiangiogenic and antiinflammatory proteins in human amniotic membrane. Cornea. 2000 May; 19(3):348-52. PMID: 10832697.
      View in: PubMed
    29. Duncan JL, Golabi M, Fredrick DR, Hoyt CS, Hwang DG, Kramer SG, Howes EL, Cunningham ET. Complex limbal choristomas in linear nevus sebaceous syndrome. Ophthalmology. 1998 Aug; 105(8):1459-65. PMID: 9709758.
      View in: PubMed
    30. Gritz DC, Hwang DG, Whitcher JP. New horizons in antibacterial therapy. Int Ophthalmol Clin. 1996; 36(2):153-70. PMID: 8950639.
      View in: PubMed
    31. Alvarado JA, Underwood JL, Green WR, Wu S, Murphy CG, Hwang DG, Moore TE, O'Day D. Detection of herpes simplex viral DNA in the iridocorneal endothelial syndrome. Arch Ophthalmol. 1994 Dec; 112(12):1601-9. PMID: 7993217.
      View in: PubMed
    32. Tam RC, Li Y, Noonberg S, Hwang DG, Lui G, Hunt CA, Garovoy MR. Biological availability and nuclease resistance extend the in vitro activity of a phosphorothioate-3'hydroxypropylamine oligonucleotide. Nucleic Acids Res. 1994 Mar 25; 22(6):977-86. PMID: 8152930; PMCID: PMC307918.
    33. Hwang DG, Kramer SG. Corneal allograft rejection after multiple blood transfusions. Am J Ophthalmol. 1993 Oct 15; 116(4):451-5. PMID: 8213975.
      View in: PubMed
    34. Hwang DG. Lamellar flap corneal biopsy. Ophthalmic Surg. 1993 Aug; 24(8):512-5. PMID: 8233312.
      View in: PubMed
    35. Hwang DG. Systemic antibiotic therapy for relapsing Haemophilus influenzae conjunctivitis. Am J Ophthalmol. 1993 Jun 15; 115(6):814-6. PMID: 8506920.
      View in: PubMed
    36. Hwang DG, Nakamura T, Trousdale MD, Smith TM. Combination antibiotic supplementation of corneal storage medium. Am J Ophthalmol. 1993 Mar 15; 115(3):299-308. PMID: 8442488.
      View in: PubMed
    37. Kwitko S, Garbus JJ, Hwang D, Gauderman WJ, McDonnell PJ. Computer-assisted study of diurnal variation in corneal topography after penetrating keratoplasty. Ophthalmic Surg. 1992 Jan; 23(1):10-6. PMID: 1574260.
      View in: PubMed
    38. Hwang DG, Hwang PH. Pediatric penetrating keratoplasty. Semin Ophthalmol. 1991 Dec; 6(4):212-8. PMID: 10149522.
      View in: PubMed
    39. Hwang D, Ward DE, Trousdale MD, Smith RE. Human immunodeficiency virus seroprevalence among potential corneal donors from medical examiner cases. Am J Ophthalmol. 1990 Jan 15; 109(1):92-3. PMID: 2297038.
      View in: PubMed
    40. Hwang D, Stern WH, Hwang PH, MacGowan-Smith LA. Collagen shield enhancement of topical dexamethasone penetration. Arch Ophthalmol. 1989 Sep; 107(9):1375-80. PMID: 2783071.
      View in: PubMed
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