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    David Sretavan, MD, PhD

    TitleProfessor
    SchoolUCSF School of Medicine
    DepartmentOphthalmology
    Address10 Koret Way
    San Francisco CA 94143
    Phone415-476-0840
    vCardDownload vCard

      Collapse Biography 
      Collapse Education and Training
      McGill UniversityB.Sc. HonorsPhysiology1980
      Stanford UniversityM.D.Medicine1987
      Stanford UniversityPh.D.Neurobiology1987
      Rockefeller UniversityPostdoctoral ResearchLaboratory of Neurobiology1990
      University of California San FranciscoPostdoctoral ResearchHHMI1992

      Collapse Overview 
      Collapse Interests
      Glaucoma disease mechanisms, Axon injury & response, Miniaturized technology for Ophthalmic diagnosis and treatments.

      Collapse ORNG Applications 
      Collapse Websites
      Collapse Awarded Grants
      Collapse Global Health

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Song Y, Sretavan D, Salegio EA, Berg J, Huang X, Cheng T, Xiong X, Meltzer S, Han C, Nguyen TT, Bresnahan JC, Beattie MS, Jan LY, Jan YN. Regulation of axon regeneration by the RNA repair and splicing pathway. Nat Neurosci. 2015 Jun; 18(6):817-25. PMID: 25961792; PMCID: PMC4446171 [Available on 12/01/15].
      2. Fu CT, Sretavan DW. Ectopic vesicular glutamate release at the optic nerve head and axon loss in mouse experimental glaucoma. J Neurosci. 2012 Nov 7; 32(45):15859-76. PMID: 23136425; PMCID: PMC3752140.
      3. Ruggiero J, Keller C, Porco T, Naseri A, Sretavan DW. Rabbit models for continuous curvilinear capsulorhexis instruction. J Cataract Refract Surg. 2012 Jul; 38(7):1266-70. PMID: 22727296; PMCID: PMC3383622.
      4. Fu CT, Sretavan D. Involvement of EphB/Ephrin-B signaling in axonal survival in mouse experimental glaucoma. Invest Ophthalmol Vis Sci. 2012 Jan; 53(1):76-84. PMID: 22064993; PMCID: PMC3292385.
      5. Chang WC, Hawkes E, Keller CG, Sretavan DW. Axon repair: surgical application at a subcellular scale. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2010 Mar-Apr; 2(2):151-61. PMID: 20101712; PMCID: PMC3150872.
      6. Fu CT, Tran T, Sretavan D. Axonal/glial upregulation of EphB/ephrin-B signaling in mouse experimental ocular hypertension. Invest Ophthalmol Vis Sci. 2010 Feb; 51(2):991-1001. PMID: 19815726; PMCID: PMC2868457.
      7. Fu CT, Sretavan D. Laser-induced ocular hypertension in albino CD-1 mice. Invest Ophthalmol Vis Sci. 2010 Feb; 51(2):980-90. PMID: 19815738; PMCID: PMC2868470.
      8. Chang WC, Sretavan DW. Single cell and neural process experimentation using laterally applied electrical fields between pairs of closely apposed microelectrodes with vertical sidewalls. Biosens Bioelectron. 2009 Aug 15; 24(12):3600-7. PMID: 19535240; PMCID: PMC2907170.
      9. Chang WC, Kliot M, Sretavan DW. Microtechnology and nanotechnology in nerve repair. Neurol Res. 2008 Dec; 30(10):1053-62. PMID: 19079980.
        View in: PubMed
      10. Chang WC, Sretavan DW. Novel high-resolution micropatterning for neuron culture using polylysine adsorption on a cell repellant, plasma-polymerized background. Langmuir. 2008 Nov 18; 24(22):13048-57. PMID: 18925765; PMCID: PMC2767107.
      11. Du J, Tran T, Fu C, Sretavan DW. Upregulation of EphB2 and ephrin-B2 at the optic nerve head of DBA/2J glaucomatous mice coincides with axon loss. Invest Ophthalmol Vis Sci. 2007 Dec; 48(12):5567-81. PMID: 18055806.
        View in: PubMed
      12. Chang WC, Hawkes EA, Kliot M, Sretavan DW. In vivo use of a nanoknife for axon microsurgery. Neurosurgery. 2007 Oct; 61(4):683-91; discussion 691-2. PMID: 17986929.
        View in: PubMed
      13. Du J, Fu C, Sretavan DW. Eph/ephrin signaling as a potential therapeutic target after central nervous system injury. Curr Pharm Des. 2007; 13(24):2507-18. PMID: 17692019.
        View in: PubMed
      14. Chang WC, Sretavan DW. Microtechnology in medicine: the emergence of surgical microdevices. Clin Neurosurg. 2007; 54:137-47. PMID: 18504911.
        View in: PubMed
      15. Liu X, Hawkes E, Ishimaru T, Tran T, Sretavan DW. EphB3: an endogenous mediator of adult axonal plasticity and regrowth after CNS injury. J Neurosci. 2006 Mar 22; 26(12):3087-101. PMID: 16554460.
        View in: PubMed
      16. Chang WC, Keller CG, Sretavan DW. Isolation of neuronal substructures and precise neural microdissection using a nanocutting device. J Neurosci Methods. 2006 Apr 15; 152(1-2):83-90. PMID: 16253341.
        View in: PubMed
      17. Sretavan DW, Chang W, Hawkes E, Keller C, Kliot M. Microscale surgery on single axons. Neurosurgery. 2005 Oct; 57(4):635-46; discussion 635-46. PMID: 16239875.
        View in: PubMed
      18. Kantor DB, Chivatakarn O, Peer KL, Oster SF, Inatani M, Hansen MJ, Flanagan JG, Yamaguchi Y, Sretavan DW, Giger RJ, Kolodkin AL. Semaphorin 5A is a bifunctional axon guidance cue regulated by heparan and chondroitin sulfate proteoglycans. Neuron. 2004 Dec 16; 44(6):961-75. PMID: 15603739.
        View in: PubMed
      19. Goldberg JL, Vargas ME, Wang JT, Mandemakers W, Oster SF, Sretavan DW, Barres BA. An oligodendrocyte lineage-specific semaphorin, Sema5A, inhibits axon growth by retinal ganglion cells. J Neurosci. 2004 May 26; 24(21):4989-99. PMID: 15163691.
        View in: PubMed
      20. Suh LH, Oster SF, Soehrman SS, Grenningloh G, Sretavan DW. L1/Laminin modulation of growth cone response to EphB triggers growth pauses and regulates the microtubule destabilizing protein SCG10. J Neurosci. 2004 Feb 25; 24(8):1976-86. PMID: 14985440.
        View in: PubMed
      21. Oster SF, Deiner M, Birgbauer E, Sretavan DW. Ganglion cell axon pathfinding in the retina and optic nerve. Semin Cell Dev Biol. 2004 Feb; 15(1):125-36. PMID: 15036215.
        View in: PubMed
      22. Beggs HE, Schahin-Reed D, Zang K, Goebbels S, Nave KA, Gorski J, Jones KR, Sretavan D, Reichardt LF. FAK deficiency in cells contributing to the basal lamina results in cortical abnormalities resembling congenital muscular dystrophies. Neuron. 2003 Oct 30; 40(3):501-14. PMID: 14642275; PMCID: PMC2758566.
      23. Oster SF, Sretavan DW. Connecting the eye to the brain: the molecular basis of ganglion cell axon guidance. Br J Ophthalmol. 2003 May; 87(5):639-45. PMID: 12714414; PMCID: PMC1771639.
      24. Oster SF, Bodeker MO, He F, Sretavan DW. Invariant Sema5A inhibition serves an ensheathing function during optic nerve development. Development. 2003 Feb; 130(4):775-84. PMID: 12506007.
        View in: PubMed
      25. Birgbauer E, Oster SF, Severin CG, Sretavan DW. Retinal axon growth cones respond to EphB extracellular domains as inhibitory axon guidance cues. Development. 2001 Aug; 128(15):3041-8. PMID: 11532925.
        View in: PubMed
      26. Birgbauer E, Cowan CA, Sretavan DW, Henkemeyer M. Kinase independent function of EphB receptors in retinal axon pathfinding to the optic disc from dorsal but not ventral retina. Development. 2000 Mar; 127(6):1231-41. PMID: 10683176.
        View in: PubMed
      27. Zhang F, Lu C, Severin C, Sretavan DW. GAP-43 mediates retinal axon interaction with lateral diencephalon cells during optic tract formation. Development. 2000 Mar; 127(5):969-80. PMID: 10662636.
        View in: PubMed
      28. Deiner MS, Sretavan DW. Altered midline axon pathways and ectopic neurons in the developing hypothalamus of netrin-1- and DCC-deficient mice. J Neurosci. 1999 Nov 15; 19(22):9900-12. PMID: 10559399.
        View in: PubMed
      29. Marcus RC, Shimamura K, Sretavan D, Lai E, Rubenstein JL, Mason CA. Domains of regulatory gene expression and the developing optic chiasm: correspondence with retinal axon paths and candidate signaling cells. J Comp Neurol. 1999 Jan 18; 403(3):346-58. PMID: 9886035.
        View in: PubMed
      30. Sretavan DW, Kruger K. Randomized retinal ganglion cell axon routing at the optic chiasm of GAP-43-deficient mice: association with midline recrossing and lack of normal ipsilateral axon turning. J Neurosci. 1998 Dec 15; 18(24):10502-13. PMID: 9852588.
        View in: PubMed
      31. Kruger K, Tam AS, Lu C, Sretavan DW. Retinal ganglion cell axon progression from the optic chiasm to initiate optic tract development requires cell autonomous function of GAP-43. J Neurosci. 1998 Aug 1; 18(15):5692-705. PMID: 9671660.
        View in: PubMed
      32. Mason CA, Sretavan DW. Glia, neurons, and axon pathfinding during optic chiasm development. Curr Opin Neurobiol. 1997 Oct; 7(5):647-53. PMID: 9384544.
        View in: PubMed
      33. Deiner MS, Kennedy TE, Fazeli A, Serafini T, Tessier-Lavigne M, Sretavan DW. Netrin-1 and DCC mediate axon guidance locally at the optic disc: loss of function leads to optic nerve hypoplasia. Neuron. 1997 Sep; 19(3):575-89. PMID: 9331350.
        View in: PubMed
      34. Sretavan DW, Puré E, Siegel MW, Reichardt LF. Disruption of retinal axon ingrowth by ablation of embryonic mouse optic chiasm neurons. Science. 1995 Jul 7; 269(5220):98-101. PMID: 7541558.
        View in: PubMed
      35. Sretavan DW, Feng L, Puré E, Reichardt LF. Embryonic neurons of the developing optic chiasm express L1 and CD44, cell surface molecules with opposing effects on retinal axon growth. Neuron. 1994 May; 12(5):957-75. PMID: 7514428; PMCID: PMC2711898.
      36. Sretavan DW, Reichardt LF. Time-lapse video analysis of retinal ganglion cell axon pathfinding at the mammalian optic chiasm: growth cone guidance using intrinsic chiasm cues. Neuron. 1993 Apr; 10(4):761-77. PMID: 8386532.
        View in: PubMed
      37. Sretavan DW. Pathfinding at the mammalian optic chiasm. Curr Opin Neurobiol. 1993 Feb; 3(1):45-52. PMID: 8453289.
        View in: PubMed
      38. Reichardt LF, Bossy B, de Curtis I, Neugebauer KM, Venstrom K, Sretavan D. Adhesive interactions that regulate development of the retina and primary visual projection. Cold Spring Harb Symp Quant Biol. 1992; 57:419-29. PMID: 1339677.
        View in: PubMed
      39. Sretavan DW. Specific routing of retinal ganglion cell axons at the mammalian optic chiasm during embryonic development. J Neurosci. 1990 Jun; 10(6):1995-2007. PMID: 2162389.
        View in: PubMed
      40. Sretavan DW, Shatz CJ, Stryker MP. Modification of retinal ganglion cell axon morphology by prenatal infusion of tetrodotoxin. Nature. 1988 Dec 1; 336(6198):468-71. PMID: 2461517.
        View in: PubMed
      41. Garraghty PE, Shatz CJ, Sretavan DW, Sur M. Axon arbors of X and Y retinal ganglion cells are differentially affected by prenatal disruption of binocular inputs. Proc Natl Acad Sci U S A. 1988 Oct; 85(19):7361-5. PMID: 3174640; PMCID: PMC282186.
      42. Sretavan DW, Shatz CJ. Axon trajectories and pattern of terminal arborization during the prenatal development of the cat's retinogeniculate pathway. J Comp Neurol. 1987 Jan 15; 255(3):386-400. PMID: 3819020.
        View in: PubMed
      43. Sretavan DW, Shatz CJ. Prenatal development of cat retinogeniculate axon arbors in the absence of binocular interactions. J Neurosci. 1986 Apr; 6(4):990-1003. PMID: 3701418.
        View in: PubMed
      44. Shatz CJ, Sretavan DW. Interactions between retinal ganglion cells during the development of the mammalian visual system. Annu Rev Neurosci. 1986; 9:171-207. PMID: 2423004.
        View in: PubMed
      45. Sretavan DW, Shatz CJ. Prenatal development of retinal ganglion cell axons: segregation into eye-specific layers within the cat's lateral geniculate nucleus. J Neurosci. 1986 Jan; 6(1):234-51. PMID: 3944621.
        View in: PubMed
      46. Sretavan D, Shatz CJ. Prenatal development of individual retinogeniculate axons during the period of segregation. Nature. 1984 Apr 26-May 2; 308(5962):845-8. PMID: 6201743.
        View in: PubMed
      47. Sretavan D, Dykes RW. The organization of two cutaneous submodalities in the forearm region of area 3b of cat somatosensory cortex. J Comp Neurol. 1983 Feb 1; 213(4):381-98. PMID: 6300198.
        View in: PubMed
      48. Dykes RW, Rasmusson DD, Sretavan D, Rehman NB. Submodality segregation and receptive-field sequences in cuneate, gracile, and external cuneate nuclei of the cat. J Neurophysiol. 1982 Mar; 47(3):389-416. PMID: 6461730.
        View in: PubMed
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