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    David Wilson, MD, PhD

    TitleAssistant Professor in Residence
    SchoolUCSF School of Medicine
    DepartmentRadiology and Biomedical Imaging
    Address505 Parnassus Ave, Long
    San Francisco CA 94143
    Phone415-514-6229

       Biography 
       Awards and Honors
      University of California, San Francisco2009Margulis Society Research Award
      Radiological Society of North America2009Resident/Fellowship Research Grant
      National Institutes of Health2007Resident Training Grant Award (NIBIB)
      2004Spotnitz Award for Excellence in Research of Neoplastic Diseases
      Harvard University1996Magna Cum Laude, Biochemistry

       Overview 
       Overview
      David M. Wilson, MD, PhD, is an Assistant Professor in Residence at the University of California, San Francisco. Dr. Wilson received his MD and PhD from Columbia University in New York, and completed his residency in Diagnostic Radiology at the University of California, San Francisco in 2009, followed by a fellowship in Neuroradiology at the UCSF in 2010.

      Dr. Wilson’s research interest is the development of new molecular probes for brain and tumor imaging. He is mainly interested in molecular imaging approaches where structural and biochemical insight is required. Recently, Dr. Wilson’s research consist of the development of new agents for hyperpolarized 13C spectroscopy, and his goal is to identify positron emission tomography (PET) that correlates for imaging in animal models.

      Overall Dr. Wilson’s research goal is to bring new technology into his studies. His efforts have resulted into 10 peer-reviewed publications, many scientific abstracts, and 217 published articles.

      Expertise:
      Neuroradiology

      Specialty:
      Positron emission tomography (PET)

      Professional Interests:
      Molecular imaging, MR spectroscopy

      Education and Training:
      • Medical School: Columbia University, New York
      • Internship: University of Hawaii Residency Program - Transitional Program
      • Residency: University of California, San Francisco - Diagnostic Radiology
      • Fellowship: University of California, San Francisco - Neuroradiology
      • Doctor of Philosophy: Columbia University, New York
      • California Medical License, A95997
      • American Board of Radiology, Certificate in Diagnostic Radiology

       Interests
      Molecular imaging, MR spectroscopy, prostate.


       Bibliographic 
       Publications
      Publications by year:
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      1. McNeill DR, Paramasivam M, Baldwin J, Huang J, Vyjayanti VN, Seidman MM, Wilson DM. NEIL1 Responds and Binds to Psoralen-induced DNA Interstrand Crosslinks. J Biol Chem. 2013 May 3; 288(18):12426-36.
        View in: PubMed
      2. Sykora P, Yang JL, Ferrarelli LK, Tian J, Tadokoro T, Kulkarni A, Weissman L, Keijzers G, Wilson DM, Mattson MP, Bohr VA. Modulation of DNA base excision repair during neuronal differentiation. Neurobiol Aging. 2013 Jul; 34(7):1717-27.
        View in: PubMed
      3. Koelsch BL, Keshari KR, Peeters TH, Larson PE, Wilson DM, Kurhanewicz J. Diffusion MR of hyperpolarized (13)C molecules in solution. Analyst. 2013 Jan 22; 138(4):1011-4.
        View in: PubMed
      4. Calderón F, Wilson DM, Gamo FJ. Antimalarial drug discovery: recent progress and future directions. Prog Med Chem. 2013; 52:97-151.
        View in: PubMed
      5. Keshari KR, Sriram R, Koelsch BL, Van Criekinge M, Wilson DM, Kurhanewicz J, Wang ZJ. Hyperpolarized 13C-Pyruvate Magnetic Resonance Reveals Rapid Lactate Export in Metastatic Renal Cell Carcinomas. Cancer Res. 2013 Jan 15; 73(2):529-38.
        View in: PubMed
      6. Dorjsuren D, Kim D, Vyjayanti VN, Maloney DJ, Jadhav A, Wilson DM, Simeonov A. Diverse Small Molecule Inhibitors of Human Apurinic/Apyrimidinic Endonuclease APE1 Identified from a Screen of a Large Public Collection. PLoS One. 2012; 7(10):e47974.
        View in: PubMed
      7. Della-Maria J, Hegde ML, McNeill DR, Matsumoto Y, Tsai MS, Ellenberger T, Wilson DM, Mitra S, Tomkinson AE. The Interaction between Polynucleotide Kinase Phosphatase and the DNA Repair Protein XRCC1 Is Critical for Repair of DNA Alkylation Damage and Stable Association at DNA Damage Sites. J Biol Chem. 2012 Nov 9; 287(46):39233-44.
        View in: PubMed
      8. Tadokoro T, Ramamoorthy M, Popuri V, May A, Tian J, Sykora P, Rybanska I, Wilson DM, Croteau DL, Bohr VA. Human RECQL5 participates in the removal of endogenous DNA damage. Mol Biol Cell. 2012 Nov; 23(21):4273-85.
        View in: PubMed
      9. Møllersen L, Rowe AD, Illuzzi JL, Hildrestrand GA, Gerhold KJ, Tveterås L, Bjølgerud A, Wilson DM, Bjørås M, Klungland A. Neil1 is a genetic modifier of somatic and germline CAG trinucleotide repeat instability in R6/1 mice. Hum Mol Genet. 2012 Nov 15; 21(22):4939-47.
        View in: PubMed
      10. Kruidenier L, Chung CW, Cheng Z, Liddle J, Che K, Joberty G, Bantscheff M, Bountra C, Bridges A, Diallo H, Eberhard D, Hutchinson S, Jones E, Katso R, Leveridge M, Mander PK, Mosley J, Ramirez-Molina C, Rowland P, Schofield CJ, Sheppard RJ, Smith JE, Swales C, Tanner R, Thomas P, Tumber A, Drewes G, Oppermann U, Patel DJ, Lee K, Wilson DM. A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature. 2012 Aug 16; 488(7411):404-8.
        View in: PubMed
      11. Pan ZG, Zhang QY, Lu ZB, Quinto T, Rozenvald IB, Liu LT, Wilson D, Reddy V, Huang Q, Wang HY, Ren YS. Extracavitary KSHV-associated large B-Cell lymphoma: a distinct entity or a subtype of primary effusion lymphoma? Study of 9 cases and review of an additional 43 cases. Am J Surg Pathol. 2012 Aug; 36(8):1129-40.
        View in: PubMed
      12. Wilson DM, Boughter JD, Lemon CH. Bitter taste stimuli induce differential neural codes in mouse brain. PLoS One. 2012; 7(7):e41597.
        View in: PubMed
      13. Berquist BR, Canugovi C, Sykora P, Wilson DM, Bohr VA. Human Cockayne syndrome B protein reciprocally communicates with mitochondrial proteins and promotes transcriptional elongation. Nucleic Acids Res. 2012 Sep 1; 40(17):8392-405.
        View in: PubMed
      14. Appukuttan B, McFarland TJ, Stempel A, Kassem JB, Hartzell M, Zhang Y, Bond D, West K, Wilson R, Stout A, Pan Y, Ilias H, Robertson K, Klein ML, Wilson D, Smith JR, Stout JT. The related transcriptional enhancer factor-1 isoform, TEAD4(216), can repress vascular endothelial growth factor expression in mammalian cells. PLoS One. 2012; 7(6):e31260.
        View in: PubMed
      15. Schwartz GK, Carvajal RD, Midgley R, Rodig SJ, Stockman PK, Ataman O, Wilson D, Das S, Shapiro GI. Phase I study of barasertib (AZD1152), a selective inhibitor of Aurora B kinase, in patients with advanced solid tumors. Invest New Drugs. 2013 Apr; 31(2):370-80.
        View in: PubMed
      16. Keshari KR, Kurhanewicz J, Macdonald JM, Wilson DM. Generating contrast in hyperpolarized 13C MRI using ligand-receptor interactions. Analyst. 2012 Aug 7; 137(15):3427-9.
        View in: PubMed
      17. Goula AV, Pearson CE, Della Maria J, Trottier Y, Tomkinson AE, Wilson DM, Merienne K. The nucleotide sequence, DNA damage location, and protein stoichiometry influence the base excision repair outcome at CAG/CTG repeats. Biochemistry. 2012 May 8; 51(18):3919-32.
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      18. Scheibye-Knudsen M, Ramamoorthy M, Sykora P, Maynard S, Lin PC, Minor RK, Wilson DM, Cooper M, Spencer R, de Cabo R, Croteau DL, Bohr VA. Cockayne syndrome group B protein prevents the accumulation of damaged mitochondria by promoting mitochondrial autophagy. J Exp Med. 2012 Apr 9; 209(4):855-69.
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      19. Rai G, Vyjayanti VN, Dorjsuren D, Simeonov A, Jadhav A, Wilson DM, Maloney DJ. Synthesis, biological evaluation, and structure-activity relationships of a novel class of apurinic/apyrimidinic endonuclease 1 inhibitors. J Med Chem. 2012 Apr 12; 55(7):3101-12.
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      20. Sultana R, McNeill DR, Abbotts R, Mohammed MZ, Zdzienicka MZ, Qutob H, Seedhouse C, Laughton CA, Fischer PM, Patel PM, Wilson DM, Madhusudan S. Synthetic lethal targeting of DNA double-strand break repair deficient cells by human apurinic/apyrimidinic endonuclease inhibitors. Int J Cancer. 2012 Nov 15; 131(10):2433-44.
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      21. Skidmore J, Atcha Z, Boucherat E, Castelletti L, Chen DW, Coppo FT, Cutler L, Dunsdon RM, Heath BM, Hutchings R, Hurst DN, Javed S, Martin S, Maskell ES, Norton D, Pemberton DJ, Redshaw S, Rutter R, Sehmi SS, Scoccitti T, Temple HE, Theobald P, Ward RW, Wilson DM. The discovery of 2-fluoro-N-(3-fluoro-4-(5-((4-morpholinobutyl)amino)-1,3,4-oxadiazol-2-yl)phenyl)benzamide, a full agonist of the alpha-7 nicotinic acetylcholine receptor showing efficacy in the novel object recognition model of cognition enhancement. Bioorg Med Chem Lett. 2012 May 15; 22(10):3531-4.
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      22. Skidmore J, Atcha Z, Boucherat E, Castelletti L, Chen DW, Coppo FT, Cutler L, Dunsdon RM, Heath BM, Hutchings R, Hurst DN, Javed S, Martin S, Maskell ES, Norton D, Pemberton DJ, Redshaw S, Rutter R, Sehmi SS, Scoccitti T, Temple HE, Theobald P, Ward RW, Wilson DM. Identification of a series of 1,3,4-oxadiazol-2-amines as potent alpha-7 agonists with efficacy in the novel object recognition model of cognition. Bioorg Med Chem Lett. 2012 May 15; 22(10):3560-3.
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      23. Berquist BR, Wilson DM. Pathways for repairing and tolerating the spectrum of oxidative DNA lesions. Cancer Lett. 2012 Dec 31; 327(1-2):61-72.
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      24. Hanssen-Bauer A, Solvang-Garten K, Gilljam KM, Torseth K, Wilson DM, Akbari M, Otterlei M. The region of XRCC1 which harbours the three most common nonsynonymous polymorphic variants, is essential for the scaffolding function of XRCC1. DNA Repair (Amst). 2012 Apr 1; 11(4):357-66.
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      25. Bamborough P, Diallo H, Goodacre JD, Gordon L, Lewis A, Seal JT, Wilson DM, Woodrow MD, Chung CW. Fragment-based discovery of bromodomain inhibitors part 2: optimization of phenylisoxazole sulfonamides. J Med Chem. 2012 Jan 26; 55(2):587-96.
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      26. Wilson DM, Iwata BA, Bloom SE. Computer-assisted measurement of wound size associated with self-injurious behavior. J Appl Behav Anal. 2012; 45(4):797-808.
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      27. Dozier CL, Iwata BA, Thomason-Sassi J, Worsdell AS, Wilson DM. A comparison of two pairing procedures to establish praise as a reinforcer. J Appl Behav Anal. 2012; 45(4):721-35.
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      28. Illuzzi JL, Wilson DM. Base excision repair: contribution to tumorigenesis and target in anticancer treatment paradigms. Curr Med Chem. 2012; 19(23):3922-36.
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      29. Kim YJ, Wilson DM. Overview of base excision repair biochemistry. Curr Mol Pharmacol. 2012 Jan; 5(1):3-13.
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      30. Sykora P, Wilson DM, Bohr VA. Repair of persistent strand breaks in the mitochondrial genome. Mech Ageing Dev. 2012 Apr; 133(4):169-75.
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      31. Case JB, Dean C, Wilson DM, Knudsen JM, James SP, Palmer RH. Comparison of the mechanical behaviors of locked and nonlocked plate/screw fixation applied to experimentally induced rotational osteotomies in canine ilia. Vet Surg. 2012 Jan; 41(1):103-13.
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      32. Keshari KR, Kurhanewicz J, Bok R, Larson PE, Vigneron DB, Wilson DM. Hyperpolarized 13C dehydroascorbate as an endogenous redox sensor for in vivo metabolic imaging. Proc Natl Acad Sci U S A. 2011 Nov 15; 108(46):18606-11.
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      33. Kim YJ, Kim D, Illuzzi JL, Delaplane S, Su D, Bernier M, Gross ML, Georgiadis MM, Wilson DM. S-glutathionylation of cysteine 99 in the APE1 protein impairs abasic endonuclease activity. J Mol Biol. 2011 Dec 2; 414(3):313-26.
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      34. Saribasak H, Maul RW, Cao Z, McClure RL, Yang W, McNeill DR, Wilson DM, Gearhart PJ. XRCC1 suppresses somatic hypermutation and promotes alternative nonhomologous end joining in Igh genes. J Exp Med. 2011 Oct 24; 208(11):2209-16.
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      35. Naidu MD, Agarwal R, Pena LA, Cunha L, Mezei M, Shen M, Wilson DM, Liu Y, Sanchez Z, Chaudhary P, Wilson SH, Waring MJ. Lucanthone and its derivative hycanthone inhibit apurinic endonuclease-1 (APE1) by direct protein binding. PLoS One. 2011; 6(9):e23679.
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      36. Lemon CH, Wilson DM, Brasser SM. Differential neural representation of oral ethanol by central taste-sensitive neurons in ethanol-preferring and genetically heterogeneous rats. J Neurophysiol. 2011 Dec; 106(6):3145-56.
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      37. Hu S, Zhu M, Yoshihara HA, Wilson DM, Keshari KR, Shin P, Reed G, von Morze C, Bok R, Larson PE, Kurhanewicz J, Vigneron DB. In vivo measurement of normal rat intracellular pyruvate and lactate levels after injection of hyperpolarized [1-(13)C]alanine. Magn Reson Imaging. 2011 Oct; 29(8):1035-40.
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      38. Hanssen-Bauer A, Solvang-Garten K, Sundheim O, Peña-Diaz J, Andersen S, Slupphaug G, Krokan HE, Wilson DM, Akbari M, Otterlei M. XRCC1 coordinates disparate responses and multiprotein repair complexes depending on the nature and context of the DNA damage. Environ Mol Mutagen. 2011 Oct; 52(8):623-35.
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      39. Kim WC, Berquist BR, Chohan M, Uy C, Wilson DM, Lee CH. Characterization of the endoribonuclease active site of human apurinic/apyrimidinic endonuclease 1. J Mol Biol. 2011 Sep 2; 411(5):960-71.
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      40. McNeill DR, Lin PC, Miller MG, Pistell PJ, de Souza-Pinto NC, Fishbein KW, Spencer RG, Liu Y, Pettan-Brewer C, Ladiges WC, Wilson DM. XRCC1 haploinsufficiency in mice has little effect on aging, but adversely modifies exposure-dependent susceptibility. Nucleic Acids Res. 2011 Oct; 39(18):7992-8004.
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      41. Yang JL, Sykora P, Wilson DM, Mattson MP, Bohr VA. The excitatory neurotransmitter glutamate stimulates DNA repair to increase neuronal resiliency. Mech Ageing Dev. 2011 Aug; 132(8-9):405-11.
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      42. Sykora P, Croteau DL, Bohr VA, Wilson DM. Aprataxin localizes to mitochondria and preserves mitochondrial function. Proc Natl Acad Sci U S A. 2011 May 3; 108(18):7437-42.
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      43. von Morze C, Larson PE, Hu S, Keshari K, Wilson DM, Ardenkjaer-Larsen JH, Goga A, Bok R, Kurhanewicz J, Vigneron DB. Imaging of blood flow using hyperpolarized [(13)C]urea in preclinical cancer models. J Magn Reson Imaging. 2011 Mar; 33(3):692-7.
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      44. Mohammed MZ, Vyjayanti VN, Laughton CA, Dekker LV, Fischer PM, Wilson DM, Abbotts R, Shah S, Patel PM, Hickson ID, Madhusudan S. Development and evaluation of human AP endonuclease inhibitors in melanoma and glioma cell lines. Br J Cancer. 2011 Feb 15; 104(4):653-63.
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      45. Wilson DM, Kim D, Berquist BR, Sigurdson AJ. Variation in base excision repair capacity. Mutat Res. 2011 Jun 3; 711(1-2):100-12.
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      46. Maul RW, Saribasak H, Martomo SA, McClure RL, Yang W, Vaisman A, Gramlich HS, Schatz DG, Woodgate R, Wilson DM, Gearhart PJ. Uracil residues dependent on the deaminase AID in immunoglobulin gene variable and switch regions. Nat Immunol. 2011 Jan; 12(1):70-6.
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      47. Chen AP, Hurd RE, Gu YP, Wilson DM, Cunningham CH. (13)C MR reporter probe system using dynamic nuclear polarization. NMR Biomed. 2011 Jun; 24(5):514-20.
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      48. Dorjsuren D, Kim D, Maloney DJ, Wilson DM, Simeonov A. Complementary non-radioactive assays for investigation of human flap endonuclease 1 activity. Nucleic Acids Res. 2011 Jan; 39(2):e11.
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      49. Lowe JA, Jones P, Wilson DM. Network biology as a new approach to drug discovery. Curr Opin Drug Discov Devel. 2010 Sep; 13(5):524-6.
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      50. Wilson DM, Simeonov A. Small molecule inhibitors of DNA repair nuclease activities of APE1. Cell Mol Life Sci. 2010 Nov; 67(21):3621-31.
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      51. Tell G, Wilson DM. Targeting DNA repair proteins for cancer treatment. Cell Mol Life Sci. 2010 Nov; 67(21):3569-72.
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      52. Niculescu-Duvaz D, Niculescu-Duvaz I, Suijkerbuijk BM, Ménard D, Zambon A, Nourry A, Davies L, Manne HA, Friedlos F, Ogilvie L, Hedley D, Takle AK, Wilson DM, Pons JF, Coulter T, Kirk R, Cantarino N, Whittaker S, Marais R, Springer CJ. Novel tricyclic pyrazole BRAF inhibitors with imidazole or furan central scaffolds. Bioorg Med Chem. 2010 Sep 15; 18(18):6934-52.
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      53. Wilson DM, Brooks PJ. The mitochondrial genome: dynamics, mechanisms of repair, and a target in disease and therapy. Environ Mol Mutagen. 2010 Jun; 51(5):349-51.
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      54. Akbari M, Solvang-Garten K, Hanssen-Bauer A, Lieske NV, Pettersen HS, Pettersen GK, Wilson DM, Krokan HE, Otterlei M. Direct interaction between XRCC1 and UNG2 facilitates rapid repair of uracil in DNA by XRCC1 complexes. DNA Repair (Amst). 2010 Jul 1; 9(7):785-95.
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      55. Hurd RE, Yen YF, Mayer D, Chen A, Wilson D, Kohler S, Bok R, Vigneron D, Kurhanewicz J, Tropp J, Spielman D, Pfefferbaum A. Metabolic imaging in the anesthetized rat brain using hyperpolarized [1-13C] pyruvate and [1-13C] ethyl pyruvate. Magn Reson Med. 2010 May; 63(5):1137-43.
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      56. Wilson DM, Keshari KR, Larson PE, Chen AP, Hu S, Van Criekinge M, Bok R, Nelson SJ, Macdonald JM, Vigneron DB, Kurhanewicz J. Multi-compound polarization by DNP allows simultaneous assessment of multiple enzymatic activities in vivo. J Magn Reson. 2010 Jul; 205(1):141-7.
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      57. Berquist BR, Singh DK, Fan J, Kim D, Gillenwater E, Kulkarni A, Bohr VA, Ackerman EJ, Tomkinson AE, Wilson DM. Functional capacity of XRCC1 protein variants identified in DNA repair-deficient Chinese hamster ovary cell lines and the human population. Nucleic Acids Res. 2010 Aug; 38(15):5023-35.
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      58. Aamann MD, Sorensen MM, Hvitby C, Berquist BR, Muftuoglu M, Tian J, de Souza-Pinto NC, Scheibye-Knudsen M, Wilson DM, Stevnsner T, Bohr VA. Cockayne syndrome group B protein promotes mitochondrial DNA stability by supporting the DNA repair association with the mitochondrial membrane. FASEB J. 2010 Jul; 24(7):2334-46.
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      59. Wilson DM, Seidman MM. A novel link to base excision repair? Trends Biochem Sci. 2010 May; 35(5):247-52.
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      60. Keshari KR, Kurhanewicz J, Jeffries RE, Wilson DM, Dewar BJ, Van Criekinge M, Zierhut M, Vigneron DB, Macdonald JM. Hyperpolarized (13)C spectroscopy and an NMR-compatible bioreactor system for the investigation of real-time cellular metabolism. Magn Reson Med. 2010 Feb; 63(2):322-9.
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      61. Nichols PL, Brand J, Briggs M, D'Angeli M, Farge J, Garland SL, Goldsmith P, Hutchings R, Kilford I, Li HY, MacPherson D, Nimmo F, Sanderson FD, Sehmi S, Shuker N, Skidmore J, Stott M, Sweeting J, Tajuddin H, Takle AK, Trani G, Wall ID, Ward R, Wilson DM, Witty D. Potent oxadiazole CGRP receptor antagonists for the potential treatment of migraine. Bioorg Med Chem Lett. 2010 Feb 15; 20(4):1368-72.
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      62. Keshari KR, Wilson DM, Chen AP, Bok R, Larson PE, Hu S, Van Criekinge M, Macdonald JM, Vigneron DB, Kurhanewicz J. Hyperpolarized [2-13C]-fructose: a hemiketal DNP substrate for in vivo metabolic imaging. J Am Chem Soc. 2009 Dec 9; 131(48):17591-6.
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      63. Goula AV, Berquist BR, Wilson DM, Wheeler VC, Trottier Y, Merienne K. Stoichiometry of base excision repair proteins correlates with increased somatic CAG instability in striatum over cerebellum in Huntington's disease transgenic mice. PLoS Genet. 2009 Dec; 5(12):e1000749.
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      64. Brust A, Palant E, Croker DE, Colless B, Drinkwater R, Patterson B, Schroeder CI, Wilson D, Nielsen CK, Smith MT, Alewood D, Alewood PF, Lewis RJ. chi-Conopeptide pharmacophore development: toward a novel class of norepinephrine transporter inhibitor (Xen2174) for pain. J Med Chem. 2009 Nov 26; 52(22):6991-7002.
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      65. Tell G, Wilson DM, Lee CH. Intrusion of a DNA repair protein in the RNome world: is this the beginning of a new era? Mol Cell Biol. 2010 Jan; 30(2):366-71.
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      66. Karabatsou K, Kiehl TR, Wilson DM, Hendler A, Guha A. Potential role of 18fluorodeoxyglucose-positron emission tomography/computed tomography in differentiating benign neurofibroma from malignant peripheral nerve sheath tumor associated with neurofibromatosis 1. Neurosurgery. 2009 Oct; 65(4 Suppl):A160-70.
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      67. Lowe JA, Jones P, Wilson DM. The importance of target validation in drug discovery and development. Curr Opin Drug Discov Devel. 2009 Sep; 12(5):581-4.
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      68. Dorjsuren D, Wilson DM, Beard WA, McDonald JP, Austin CP, Woodgate R, Wilson SH, Simeonov A. A real-time fluorescence method for enzymatic characterization of specialized human DNA polymerases. Nucleic Acids Res. 2009 Oct; 37(19):e128.
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      69. Wiemels JL, Wilson D, Patil C, Patoka J, McCoy L, Rice T, Schwartzbaum J, Heimberger A, Sampson JH, Chang S, Prados M, Wiencke JK, Wrensch M. IgE, allergy, and risk of glioma: update from the San Francisco Bay Area Adult Glioma Study in the temozolomide era. Int J Cancer. 2009 Aug 1; 125(3):680-7.
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      70. Berquist BR, Wilson DM. Nucleic acid binding activity of human Cockayne syndrome B protein and identification of Ca(2+) as a novel metal cofactor. J Mol Biol. 2009 Sep 4; 391(5):820-32.
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      71. Schurman SH, Hedayati M, Wang Z, Singh DK, Speina E, Zhang Y, Becker K, Macris M, Sung P, Wilson DM, Croteau DL, Bohr VA. Direct and indirect roles of RECQL4 in modulating base excision repair capacity. Hum Mol Genet. 2009 Sep 15; 18(18):3470-83.
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      72. Simeonov A, Kulkarni A, Dorjsuren D, Jadhav A, Shen M, McNeill DR, Austin CP, Wilson DM. Identification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1. PLoS One. 2009; 4(6):e5740.
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      73. McNeill DR, Lam W, DeWeese TL, Cheng YC, Wilson DM. Impairment of APE1 function enhances cellular sensitivity to clinically relevant alkylators and antimetabolites. Mol Cancer Res. 2009 Jun; 7(6):897-906.
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      74. Wilson DM, Hurd RE, Keshari K, Van Criekinge M, Chen AP, Nelson SJ, Vigneron DB, Kurhanewicz J. Generation of hyperpolarized substrates by secondary labeling with [1,1-13C] acetic anhydride. Proc Natl Acad Sci U S A. 2009 Apr 7; 106(14):5503-7.
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      75. Wyatt MD, Wilson DM. Participation of DNA repair in the response to 5-fluorouracil. Cell Mol Life Sci. 2009 Mar; 66(5):788-99.
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      76. Bell RB, Wilson DM. Is the use of arch bars or interdental wire fixation necessary for successful outcomes in the open reduction and internal fixation of mandibular angle fractures? J Oral Maxillofac Surg. 2008 Oct; 66(10):2116-22.
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      77. Southam E, Cilia J, Gartlon JE, Woolley ML, Lacroix LP, Jennings CA, Cluderay JE, Reavill C, Rourke C, Wilson DM, Dawson LA, Medhurst AD, Jones DN. Preclinical investigations into the antipsychotic potential of the novel histamine H3 receptor antagonist GSK207040. Psychopharmacology (Berl). 2009 Jan; 201(4):483-94.
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      78. Lowe JA, Jones P, Wilson DM. The role of genetic association studies in identifying new drug targets. Curr Opin Drug Discov Devel. 2008 Sep; 11(5):603-5.
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      79. Kulkarni A, McNeill DR, Gleichmann M, Mattson MP, Wilson DM. XRCC1 protects against the lethality of induced oxidative DNA damage in nondividing neural cells. Nucleic Acids Res. 2008 Sep; 36(15):5111-21.
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      80. Degirmenci B, Wilson D, Laymon CM, Becker C, Mason NS, Bencherif B, Agarwal A, Luketich J, Landreneau R, Avril N. Standardized uptake value-based evaluations of solitary pulmonary nodules using F-18 fluorodeoxyglucose-PET/computed tomography. Nucl Med Commun. 2008 Jul; 29(7):614-22.
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      81. Lipton AS, Heck RW, Primak S, McNeill DR, Wilson DM, Ellis PD. Characterization of Mg2+ binding to the DNA repair protein apurinic/apyrimidic endonuclease 1 via solid-state 25Mg NMR spectroscopy. J Am Chem Soc. 2008 Jul 23; 130(29):9332-41.
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      82. Takle AK, Bamford MJ, Davies S, Davis RP, Dean DK, Gaiba A, Irving EA, King FD, Naylor A, Parr CA, Ray AM, Reith AD, Smith BB, Staton PC, Steadman JG, Stean TO, Wilson DM. The identification of potent, selective and CNS penetrant furan-based inhibitors of B-Raf kinase. Bioorg Med Chem Lett. 2008 Aug 1; 18(15):4373-6.
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      83. Liu P, Qian L, Sung JS, de Souza-Pinto NC, Zheng L, Bogenhagen DF, Bohr VA, Wilson DM, Shen B, Demple B. Removal of oxidative DNA damage via FEN1-dependent long-patch base excision repair in human cell mitochondria. Mol Cell Biol. 2008 Aug; 28(16):4975-87.
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      84. de Souza-Pinto NC, Wilson DM, Stevnsner TV, Bohr VA. Mitochondrial DNA, base excision repair and neurodegeneration. DNA Repair (Amst). 2008 Jul 1; 7(7):1098-109.
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      85. Silvaggi NR, Wilson D, Tzipori S, Allen KN. Catalytic features of the botulinum neurotoxin A light chain revealed by high resolution structure of an inhibitory peptide complex. Biochemistry. 2008 May 27; 47(21):5736-45.
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      86. Adjei AA, Cohen RB, Franklin W, Morris C, Wilson D, Molina JR, Hanson LJ, Gore L, Chow L, Leong S, Maloney L, Gordon G, Simmons H, Marlow A, Litwiler K, Brown S, Poch G, Kane K, Haney J, Eckhardt SG. Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers. J Clin Oncol. 2008 May 1; 26(13):2139-46.
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      87. Berquist BR, McNeill DR, Wilson DM. Characterization of abasic endonuclease activity of human Ape1 on alternative substrates, as well as effects of ATP and sequence context on AP site incision. J Mol Biol. 2008 May 23; 379(1):17-27.
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      88. Rao A, Kelly M, Musselman M, Ramadas J, Wilson D, Grossman W, Shenoy S. Safety, efficacy, and immune reconstitution after rituximab therapy in pediatric patients with chronic or refractory hematologic autoimmune cytopenias. Pediatr Blood Cancer. 2008 Apr; 50(4):822-5.
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      89. Paap B, Wilson DM, Sutherland BM. Human abasic endonuclease action on multilesion abasic clusters: implications for radiation-induced biological damage. Nucleic Acids Res. 2008 May; 36(8):2717-27.
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      90. Wilson DM, Bohr VA, McKinnon PJ. DNA damage, DNA repair, ageing and age-related disease. Mech Ageing Dev. 2008 Jul-Aug; 129(7-8):349-52.
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      91. Kulkarni A, Wilson DM. The involvement of DNA-damage and -repair defects in neurological dysfunction. Am J Hum Genet. 2008 Mar; 82(3):539-66.
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      92. Procopiou PA, Ancliff RA, Bamford MJ, Browning C, Connor H, Davies S, Fogden YC, Hodgson ST, Holmes DS, Looker BE, Morriss KM, Parr CA, Pickup EA, Sehmi SS, White GV, Watts CJ, Wilson DM, Woodrow MD. 4-acyl-1-(4-aminoalkoxyphenyl)-2-ketopiperazines as a novel class of non-brain-penetrant histamine H3 receptor antagonists. J Med Chem. 2007 Dec 27; 50(26):6706-17.
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      93. Corley RA, Wilson DM, Hard GC, Stebbins KE, Bartels MJ, Soelberg JJ, Dryzga MD, Gingell R, McMartin KE, Snellings WM. Dosimetry considerations in the enhanced sensitivity of male Wistar rats to chronic ethylene glycol-induced nephrotoxicity. Toxicol Appl Pharmacol. 2008 Apr 15; 228(2):165-78.
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      94. Wilson DM. Processing of nonconventional DNA strand break ends. Environ Mol Mutagen. 2007 Dec; 48(9):772-82.
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      95. Heiden D, Ford N, Wilson D, Rodriguez WR, Margolis T, Janssens B, Bedelu M, Tun N, Goemaere E, Saranchuk P, Sabapathy K, Smithuis F, Luyirika E, Drew WL. Cytomegalovirus retinitis: the neglected disease of the AIDS pandemic. PLoS Med. 2007 Dec; 4(12):e334.
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      96. Jurjevic Z, Wilson JP, Wilson DM, Casper HH. Changes in fungi and mycotoxins in pearl millet under controlled storage conditions. Mycopathologia. 2007 Nov; 164(5):229-39.
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      97. Fan J, Wilson PF, Wong HK, Urbin SS, Thompson LH, Wilson DM. XRCC1 down-regulation in human cells leads to DNA-damaging agent hypersensitivity, elevated sister chromatid exchange, and reduced survival of BRCA2 mutant cells. Environ Mol Mutagen. 2007 Jul; 48(6):491-500.
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      98. Wong HK, Muftuoglu M, Beck G, Imam SZ, Bohr VA, Wilson DM. Cockayne syndrome B protein stimulates apurinic endonuclease 1 activity and protects against agents that introduce base excision repair intermediates. Nucleic Acids Res. 2007; 35(12):4103-13.
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      99. Medhurst AD, Atkins AR, Beresford IJ, Brackenborough K, Briggs MA, Calver AR, Cilia J, Cluderay JE, Crook B, Davis JB, Davis RK, Davis RP, Dawson LA, Foley AG, Gartlon J, Gonzalez MI, Heslop T, Hirst WD, Jennings C, Jones DN, Lacroix LP, Martyn A, Ociepka S, Ray A, Regan CM, Roberts JC, Schogger J, Southam E, Stean TO, Trail BK, Upton N, Wadsworth G, Wald JA, White T, Witherington J, Woolley ML, Worby A, Wilson DM. GSK189254, a novel H3 receptor antagonist that binds to histamine H3 receptors in Alzheimer's disease brain and improves cognitive performance in preclinical models. J Pharmacol Exp Ther. 2007 Jun; 321(3):1032-45.
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      100. Cyr JE, Pearson DA, Wilson DM, Nelson CA, Guaraldi M, Azure MT, Lister-James J, Dinkelborg LM, Dean RT. Somatostatin receptor-binding peptides suitable for tumor radiotherapy with Re-188 or Re-186. Chemistry and initial biological studies. J Med Chem. 2007 Mar 22; 50(6):1354-64.
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      101. McNeill DR, Wong HK, Narayana A, Wilson DM. Lead promotes abasic site accumulation and co-mutagenesis in mammalian cells by inhibiting the major abasic endonuclease Ape1. Mol Carcinog. 2007 Feb; 46(2):91-9.
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      102. Wilson DM, Mattson MP. Neurodegeneration: nicked to death. Curr Biol. 2007 Jan 23; 17(2):R55-8.
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      103. Medhurst AD, Briggs MA, Bruton G, Calver AR, Chessell I, Crook B, Davis JB, Davis RP, Foley AG, Heslop T, Hirst WD, Medhurst SJ, Ociepka S, Ray A, Regan CM, Sargent B, Schogger J, Stean TO, Trail BK, Upton N, White T, Orlek B, Wilson DM. Structurally novel histamine H3 receptor antagonists GSK207040 and GSK334429 improve scopolamine-induced memory impairment and capsaicin-induced secondary allodynia in rats. Biochem Pharmacol. 2007 Apr 15; 73(8):1182-94.
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      104. McNeill DR, Wilson DM. A dominant-negative form of the major human abasic endonuclease enhances cellular sensitivity to laboratory and clinical DNA-damaging agents. Mol Cancer Res. 2007 Jan; 5(1):61-70.
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      105. Harrigan JA, Fan J, Momand J, Perrino FW, Bohr VA, Wilson DM. WRN exonuclease activity is blocked by DNA termini harboring 3' obstructive groups. Mech Ageing Dev. 2007 Mar; 128(3):259-66.
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      106. Wilson DM, Thompson LH. Molecular mechanisms of sister-chromatid exchange. Mutat Res. 2007 Mar 1; 616(1-2):11-23.
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      107. King AJ, Patrick DR, Batorsky RS, Ho ML, Do HT, Zhang SY, Kumar R, Rusnak DW, Takle AK, Wilson DM, Hugger E, Wang L, Karreth F, Lougheed JC, Lee J, Chau D, Stout TJ, May EW, Rominger CM, Schaber MD, Luo L, Lakdawala AS, Adams JL, Contractor RG, Smalley KS, Herlyn M, Morrissey MM, Tuveson DA, Huang PS. Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885. Cancer Res. 2006 Dec 1; 66(23):11100-5.
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      108. Wilson DM, Bohr VA. The mechanics of base excision repair, and its relationship to aging and disease. DNA Repair (Amst). 2007 Apr 1; 6(4):544-59.
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      109. Brown T, Taherbhai Z, Sexton J, Sutterfield A, Turlington M, Jones J, Stallings L, Stewart M, Buchmueller K, Mackay H, O'hare C, Kluza J, Nguyen B, Wilson D, Lee M, Hartley JA. Synthesis and biophysical evaluation of minor-groove binding C-terminus modified pyrrole and imidazole triamide analogs of distamycin. Bioorg Med Chem. 2007 Jan 1; 15(1):474-83.
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      110. Wilson DM, Varvel SA, Harloe JP, Martin BR, Lichtman AH. SR 141716 (Rimonabant) precipitates withdrawal in marijuana-dependent mice. Pharmacol Biochem Behav. 2006 Sep; 85(1):105-13.
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      111. Wilson DM, McNeill DR. Base excision repair and the central nervous system. Neuroscience. 2007 Apr 14; 145(4):1187-200.
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      112. Sokhansanj BA, Wilson DM. Estimating the effect of human base excision repair protein variants on the repair of oxidative DNA base damage. Cancer Epidemiol Biomarkers Prev. 2006 May; 15(5):1000-8.
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      113. Wilson JP, Jurjevic Z, Hanna WW, Wilson DM, Potter TL, Coy AE. Host-specific variation in infection by toxigenic fungi and contamination by mycotoxins in pearl millet and corn. Mycopathologia. 2006 Feb; 161(2):101-7.
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      114. Harrigan JA, Wilson DM, Prasad R, Opresko PL, Beck G, May A, Wilson SH, Bohr VA. The Werner syndrome protein operates in base excision repair and cooperates with DNA polymerase beta. Nucleic Acids Res. 2006; 34(2):745-54.
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      115. Carpenter EM, Hendrickson DA, James S, Franke C, Frisbie D, Trostle S, Wilson D. A mechanical study of ligature security of commercially available pre-tied ligatures versus hand tied ligatures for use in equine laparoscopy. Vet Surg. 2006 Jan; 35(1):55-9.
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      116. Muftuoglu M, Wong HK, Imam SZ, Wilson DM, Bohr VA, Opresko PL. Telomere repeat binding factor 2 interacts with base excision repair proteins and stimulates DNA synthesis by DNA polymerase beta. Cancer Res. 2006 Jan 1; 66(1):113-24.
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      117. Fan J, Matsumoto Y, Wilson DM. Nucleotide sequence and DNA secondary structure, as well as replication protein A, modulate the single-stranded abasic endonuclease activity of APE1. J Biol Chem. 2006 Feb 17; 281(7):3889-98.
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      118. Takle AK, Brown MJ, Davies S, Dean DK, Francis G, Gaiba A, Hird AW, King FD, Lovell PJ, Naylor A, Reith AD, Steadman JG, Wilson DM. The identification of potent and selective imidazole-based inhibitors of B-Raf kinase. Bioorg Med Chem Lett. 2006 Jan 15; 16(2):378-81.
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      119. Wong HK, Kim D, Hogue BA, McNeill DR, Wilson DM. DNA damage levels and biochemical repair capacities associated with XRCC1 deficiency. Biochemistry. 2005 Nov 1; 44(43):14335-43.
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      120. Sen S, Paraggio NA, Gearheart LA, Connor EE, Issa A, Coleman RS, Wilson DM, Wyatt MD, Berg MA. Effect of protein binding on ultrafast DNA dynamics: characterization of a DNA:APE1 complex. Biophys J. 2005 Dec; 89(6):4129-38.
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      121. Bamford MJ, Bailey N, Davies S, Dean DK, Francis L, Panchal TA, Parr CA, Sehmi S, Steadman JG, Takle AK, Townsend JT, Wilson DM. (1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: further optimisation as highly potent and selective MSK-1-inhibitors. Bioorg Med Chem Lett. 2005 Jul 15; 15(14):3407-11.
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      122. Bamford MJ, Alberti MJ, Bailey N, Davies S, Dean DK, Gaiba A, Garland S, Harling JD, Jung DK, Panchal TA, Parr CA, Steadman JG, Takle AK, Townsend JT, Wilson DM, Witherington J. (1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: a novel class of potent MSK-1-inhibitors. Bioorg Med Chem Lett. 2005 Jul 15; 15(14):3402-6.
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      123. Wong HK, Wilson DM. XRCC1 and DNA polymerase beta interaction contributes to cellular alkylating-agent resistance and single-strand break repair. J Cell Biochem. 2005 Jul 1; 95(4):794-804.
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      124. Fan J, Wilson DM. Protein-protein interactions and posttranslational modifications in mammalian base excision repair. Free Radic Biol Med. 2005 May 1; 38(9):1121-38.
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      125. Jurjevic Z, Wilson DM, Wilson JP, Geiser DM, Juba JH, Mubatanhema W, Widstrom NW, Rains GC. Fusarium species of the Gibberella fujikuroi complex and fumonisin contamination of pearl millet and corn in Georgia, USA. Mycopathologia. 2005 Apr; 159(3):401-6.
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      126. Opresko PL, Fan J, Danzy S, Wilson DM, Bohr VA. Oxidative damage in telomeric DNA disrupts recognition by TRF1 and TRF2. Nucleic Acids Res. 2005; 33(4):1230-9.
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      127. Wilson DM. Ape1 abasic endonuclease activity is regulated by magnesium and potassium concentrations and is robust on alternative DNA structures. J Mol Biol. 2005 Feb 4; 345(5):1003-14.
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      128. Georgakilas AG, Bennett PV, Wilson DM, Sutherland BM. Processing of bistranded abasic DNA clusters in gamma-irradiated human hematopoietic cells. Nucleic Acids Res. 2004; 32(18):5609-20.
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      129. Buntin GD, All JN, Lee RD, Wilson DM. Plant-incorporated Bacillus thuringiensis resistance for control of fall armyworm and corn earworm (Lepidoptera: Noctuidae) in corn. J Econ Entomol. 2004 Oct; 97(5):1603-11.
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      130. Ahn B, Harrigan JA, Indig FE, Wilson DM, Bohr VA. Regulation of WRN helicase activity in human base excision repair. J Biol Chem. 2004 Dec 17; 279(51):53465-74.
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      131. Sokhansanj BA, Wilson DM. Oxidative DNA damage background estimated by a system model of base excision repair. Free Radic Biol Med. 2004 Aug 1; 37(3):422-7.
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      132. Bohr VA, Metter EJ, Harrigan JA, von Kobbe C, Liu JL, Gray MD, Majumdar A, Wilson DM, Seidman MM. Werner syndrome protein 1367 variants and disposition towards coronary artery disease in Caucasian patients. Mech Ageing Dev. 2004 Jul; 125(7):491-6.
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      133. Marenstein DR, Wilson DM, Teebor GW. Human AP endonuclease (APE1) demonstrates endonucleolytic activity against AP sites in single-stranded DNA. DNA Repair (Amst). 2004 May 4; 3(5):527-33.
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      134. McNeill DR, Narayana A, Wong HK, Wilson DM. Inhibition of Ape1 nuclease activity by lead, iron, and cadmium. Environ Health Perspect. 2004 May; 112(7):799-804.
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      135. Stuart JA, Hashiguchi K, Wilson DM, Copeland WC, Souza-Pinto NC, Bohr VA. DNA base excision repair activities and pathway function in mitochondrial and cellular lysates from cells lacking mitochondrial DNA. Nucleic Acids Res. 2004; 32(7):2181-92.
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      136. Fan J, Otterlei M, Wong HK, Tomkinson AE, Wilson DM. XRCC1 co-localizes and physically interacts with PCNA. Nucleic Acids Res. 2004; 32(7):2193-201.
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      137. Cruz F, Rubin BP, Wilson D, Town A, Schroeder A, Haley A, Bainbridge T, Heinrich MC, Corless CL. Absence of BRAF and NRAS mutations in uveal melanoma. Cancer Res. 2003 Sep 15; 63(18):5761-6.
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      138. Sun X, Thrower D, Qiu J, Wu P, Zheng L, Zhou M, Bachant J, Wilson DM, Shen B. Complementary functions of the Saccharomyces cerevisiae Rad2 family nucleases in Okazaki fragment maturation, mutation avoidance, and chromosome stability. DNA Repair (Amst). 2003 Aug 12; 2(8):925-40.
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      139. Wilson DM. Properties of and substrate determinants for the exonuclease activity of human apurinic endonuclease Ape1. J Mol Biol. 2003 Jul 25; 330(5):1027-37.
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      140. Robinson LA, Wilson DM, Delaet NG, Bradley EK, Dankwardt SM, Campbell JA, Martin RL, Van Wart HE, Walker KA, Sullivan RW. Novel inhibitors of procollagen C-proteinase. Part 2: glutamic acid hydroxamates. Bioorg Med Chem Lett. 2003 Jul 21; 13(14):2381-4.
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      141. Delaet NG, Robinson LA, Wilson DM, Sullivan RW, Bradley EK, Dankwardt SM, Martin RL, Van Wart HE, Walker KA. Novel inhibitors of procollagen C-terminal proteinase. Part 1: diamino Acid hydroxamates. Bioorg Med Chem Lett. 2003 Jul 7; 13(13):2101-4.
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      142. Wilson D, Perlson L, Breslow R. Helical templating of oligopeptides by cyclodextrin dimers. Bioorg Med Chem. 2003 Jun 12; 11(12):2649-53.
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      143. Lowry DF, Hoyt DW, Khazi FA, Bagu J, Lindsey AG, Wilson DM. Investigation of the role of the histidine-aspartate pair in the human exonuclease III-like abasic endonuclease, Ape1. J Mol Biol. 2003 May 30; 329(2):311-22.
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      144. Mohrenweiser HW, Wilson DM, Jones IM. Challenges and complexities in estimating both the functional impact and the disease risk associated with the extensive genetic variation in human DNA repair genes. Mutat Res. 2003 May 15; 526(1-2):93-125.
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      145. Wilson DM, Sofinowski TM, McNeill DR. Repair mechanisms for oxidative DNA damage. Front Biosci. 2003 May 1; 8:d963-81.
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      146. Morgenstern BZ, Butani L, Wollan P, Wilson DM, Larson TS. Validity of protein-osmolality versus protein-creatinine ratios in the estimation of quantitative proteinuria from random samples of urine in children. Am J Kidney Dis. 2003 Apr; 41(4):760-6.
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      147. van Zijl PC, Zhou J, Mori N, Payen JF, Wilson D, Mori S. Mechanism of magnetization transfer during on-resonance water saturation. A new approach to detect mobile proteins, peptides, and lipids. Magn Reson Med. 2003 Mar; 49(3):440-9.
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      148. Ladd PD, Wilson DM, Kelley MR, Skalnik DG. Identification of the human HEX1/hExo1 gene promoter and characterization of elements responsible for promoter activity. DNA Repair (Amst). 2003 Feb 3; 2(2):187-98.
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      149. Kelley MR, Kow YW, Wilson DM. Disparity between DNA base excision repair in yeast and mammals: translational implications. Cancer Res. 2003 Feb 1; 63(3):549-54.
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      150. Wilson DM, Peart J, Martin BR, Bridgen DT, Byron PR, Lichtman AH. Physiochemical and pharmacological characterization of a Delta(9)-THC aerosol generated by a metered dose inhaler. Drug Alcohol Depend. 2002 Aug 1; 67(3):259-67.
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      151. Sokhansanj BA, Rodrigue GR, Fitch JP, Wilson DM. A quantitative model of human DNA base excision repair. I. Mechanistic insights. Nucleic Acids Res. 2002 Apr 15; 30(8):1817-25.
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      152. Rosengren KJ, Wilson D, Daly NL, Alewood PF, Craik DJ. Solution structures of the cis- and trans-Pro30 isomers of a novel 38-residue toxin from the venom of Hadronyche Infensa sp. that contains a cystine-knot motif within its four disulfide bonds. Biochemistry. 2002 Mar 12; 41(10):3294-301.
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      153. Hadi MZ, Ginalski K, Nguyen LH, Wilson DM. Determinants in nuclease specificity of Ape1 and Ape2, human homologues of Escherichia coli exonuclease III. J Mol Biol. 2002 Feb 22; 316(3):853-66.
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      154. Lee Bi BI, Nguyen LH, Barsky D, Fernandes M, Wilson DM. Molecular interactions of human Exo1 with DNA. Nucleic Acids Res. 2002 Feb 15; 30(4):942-9.
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      155. Wilson DM, Mubatanhema W, Jurjevic Z. Biology and ecology of mycotoxigenic Aspergillus species as related to economic and health concerns. Adv Exp Med Biol. 2002; 504:3-17.
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      156. Baugh SD, Yang Z, Leung DK, Wilson DM, Breslow R. Cyclodextrin dimers as cleavable carriers of photodynamic sensitizers. J Am Chem Soc. 2001 Dec 19; 123(50):12488-94.
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      157. Lichtman AH, Poklis JL, Poklis A, Wilson DM, Martin BR. The pharmacological activity of inhalation exposure to marijuana smoke in mice. Drug Alcohol Depend. 2001 Jul 1; 63(2):107-16.
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      158. Nguyen LH, Espert L, Mechti N, Wilson DM. The human interferon- and estrogen-regulated ISG20/HEM45 gene product degrades single-stranded RNA and DNA in vitro. Biochemistry. 2001 Jun 19; 40(24):7174-9.
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      159. Wilson DM, Barsky D. The major human abasic endonuclease: formation, consequences and repair of abasic lesions in DNA. Mutat Res. 2001 May 10; 485(4):283-307.
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      160. Beernink PT, Segelke BW, Hadi MZ, Erzberger JP, Wilson DM, Rupp B. Two divalent metal ions in the active site of a new crystal form of human apurinic/apyrimidinic endonuclease, Ape1: implications for the catalytic mechanism. J Mol Biol. 2001 Apr 6; 307(4):1023-34.
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      161. Hagopian LP, Wilson DM, Wilder DA. Assessment and treatment of problem behavior maintained by escape from attention and access to tangible items. J Appl Behav Anal. 2001; 34(2):229-32.
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      162. Milliner DS, Wilson DM, Smith LH. Phenotypic expression of primary hyperoxaluria: comparative features of types I and II. Kidney Int. 2001 Jan; 59(1):31-6.
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      163. Hadi MZ, Coleman MA, Fidelis K, Mohrenweiser HW, Wilson DM. Functional characterization of Ape1 variants identified in the human population. Nucleic Acids Res. 2000 Oct 15; 28(20):3871-9.
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      164. Chattergoon MA, Kim JJ, Yang JS, Robinson TM, Lee DJ, Dentchev T, Wilson DM, Ayyavoo V, Weiner DB. Targeted antigen delivery to antigen-presenting cells including dendritic cells by engineered Fas-mediated apoptosis. Nat Biotechnol. 2000 Sep; 18(9):974-9.
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      165. Nguyen LH, Erzberger JP, Root J, Wilson DM. The human homolog of Escherichia coli Orn degrades small single-stranded RNA and DNA oligomers. J Biol Chem. 2000 Aug 25; 275(34):25900-6.
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      166. Lichtman AH, Peart J, Poklis JL, Bridgen DT, Razdan RK, Wilson DM, Poklis A, Meng Y, Byron PR, Martin BR. Pharmacological evaluation of aerosolized cannabinoids in mice. Eur J Pharmacol. 2000 Jul 7; 399(2-3):141-9.
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      167. Barsky D, Foloppe N, Ahmadia S, Wilson DM, MacKerell AD. New insights into the structure of abasic DNA from molecular dynamics simulations. Nucleic Acids Res. 2000 Jul 1; 28(13):2613-26.
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      168. Rasmussen LJ, Rasmussen M, Lee B, Rasmussen AK, Wilson DM, Nielsen FC, Bisgaard HC. Identification of factors interacting with hMSH2 in the fetal liver utilizing the yeast two-hybrid system. In vivo interaction through the C-terminal domains of hEXO1 and hMSH2 and comparative expression analysis. Mutat Res. 2000 Jun 30; 460(1):41-52.
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      169. Nguyen LH, Barsky D, Erzberger JP, Wilson DM. Mapping the protein-DNA interface and the metal-binding site of the major human apurinic/apyrimidinic endonuclease. J Mol Biol. 2000 May 5; 298(3):447-59.
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      170. Kelley MR, Xu Y, Wilson DM, Deutsch WA. Genomic structure and characterization of the Drosophila S3 ribosomal/DNA repair gene and mutant alleles. DNA Cell Biol. 2000 Mar; 19(3):149-56.
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      171. Hadi MZ, Wilson DM. Second human protein with homology to the Escherichia coli abasic endonuclease exonuclease III. Environ Mol Mutagen. 2000; 36(4):312-24.
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      172. Bush VJ, Hallaway BJ, Ebert TA, Wilson DM, O'Kane DJ. Chemiluminescence screening assays for erythrocytes and leukocytes in urine. Methods Enzymol. 2000; 305:402-10.
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      173. Lee BI, Wilson DM. The RAD2 domain of human exonuclease 1 exhibits 5' to 3' exonuclease and flap structure-specific endonuclease activities. J Biol Chem. 1999 Dec 31; 274(53):37763-9.
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      174. Mubatanhema W, Moss MO, Frank MJ, Wilson DM. Prevalence of Fusarium species of the Liseola section on Zimbabwean corn and their ability to produce the mycotoxins zearalenone, moniliformin and fumonisin B1. Mycopathologia. 1999 Dec; 148(3):157-63.
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      175. Schild LJ, Brookman KW, Thompson LH, Wilson DM. Effects of Ape1 overexpression on cellular resistance to DNA-damaging and anticancer agents. Somat Cell Mol Genet. 1999 Nov; 25(5-6):253-62.
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      176. Lee BI, Shannon M, Stubbs L, Wilson DM. Expression specificity of the mouse exonuclease 1 (mExo1) gene. Nucleic Acids Res. 1999 Oct 15; 27(20):4114-20.
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      177. Dyck PJ, Davies JL, Wilson DM, Service FJ, Melton LJ, O'Brien PC. Risk factors for severity of diabetic polyneuropathy: intensive longitudinal assessment of the Rochester Diabetic Neuropathy Study cohort. Diabetes Care. 1999 Sep; 22(9):1479-86.
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      178. Wilson DM, Bianchi C. Improved immunodetection of nuclear antigens after sodium dodecyl sulfate treatment of formaldehyde-fixed cells. J Histochem Cytochem. 1999 Aug; 47(8):1095-100.
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      179. Erzberger JP, Wilson DM. The role of Mg2+ and specific amino acid residues in the catalytic reaction of the major human abasic endonuclease: new insights from EDTA-resistant incision of acyclic abasic site analogs and site-directed mutagenesis. J Mol Biol. 1999 Jul 9; 290(2):447-57.
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      180. Agadjanyan MG, Kim JJ, Trivedi N, Wilson DM, Monzavi-Karbassi B, Morrison LD, Nottingham LK, Dentchev T, Tsai A, Dang K, Chalian AA, Maldonado MA, Williams WV, Weiner DB. CD86 (B7-2) can function to drive MHC-restricted antigen-specific CTL responses in vivo. J Immunol. 1999 Mar 15; 162(6):3417-27.
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      181. Chaudhry MA, Dedon PC, Wilson DM, Demple B, Weinfeld M. Removal by human apurinic/apyrimidinic endonuclease 1 (Ape 1) and Escherichia coli exonuclease III of 3'-phosphoglycolates from DNA treated with neocarzinostatin, calicheamicin, and gamma-radiation. Biochem Pharmacol. 1999 Mar 1; 57(5):531-8.
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      182. Kim JJ, Trivedi NN, Wilson DM, Mahalingam S, Morrison L, Tsai A, Chattergoon MA, Dang K, Patel M, Ahn L, Boyer JD, Chalian AA, Schoemaker H, Kieber-Emmons T, Agadjanyan MA, Weiner DB, Shoemaker H. Molecular and immunological analysis of genetic prostate specific antigen (PSA) vaccine. Oncogene. 1998 Dec 17; 17(24):3125-35.
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      183. Kim JJ, Nottingham LK, Wilson DM, Bagarazzi ML, Tsai A, Morrison LD, Javadian A, Chalian AA, Agadjanyan MG, Weiner DB. Engineering DNA vaccines via co-delivery of co-stimulatory molecule genes. Vaccine. 1998 Nov; 16(19):1828-35.
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      184. Hastings Wilson T, Wilson DM. Evidence for a close association between helix IV and helix XI in the melibiose carrier of Escherichia coli. Biochim Biophys Acta. 1998 Sep 23; 1374(1-2):77-82.
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      185. Lichtman AH, Wiley JL, LaVecchia KL, Neviaser ST, Arthur DB, Wilson DM, Martin BR. Effects of SR 141716A after acute or chronic cannabinoid administration in dogs. Eur J Pharmacol. 1998 Sep 18; 357(2-3):139-48.
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      186. Kim JJ, Nottingham LK, Sin JI, Tsai A, Morrison L, Oh J, Dang K, Hu Y, Kazahaya K, Bennett M, Dentchev T, Wilson DM, Chalian AA, Boyer JD, Agadjanyan MG, Weiner DB. CD8 positive T cells influence antigen-specific immune responses through the expression of chemokines. J Clin Invest. 1998 Sep 15; 102(6):1112-24.
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      187. Wilson DM, Carney JP, Coleman MA, Adamson AW, Christensen M, Lamerdin JE. Hex1: a new human Rad2 nuclease family member with homology to yeast exonuclease 1. Nucleic Acids Res. 1998 Aug 15; 26(16):3762-8.
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      188. Salhany KE, Macon WR, Choi JK, Elenitsas R, Lessin SR, Felgar RE, Wilson DM, Przybylski GK, Lister J, Wasik MA, Swerdlow SH. Subcutaneous panniculitis-like T-cell lymphoma: clinicopathologic, immunophenotypic, and genotypic analysis of alpha/beta and gamma/delta subtypes. Am J Surg Pathol. 1998 Jul; 22(7):881-93.
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      189. Erzberger JP, Barsky D, Schärer OD, Colvin ME, Wilson DM. Elements in abasic site recognition by the major human and Escherichia coli apurinic/apyrimidinic endonucleases. Nucleic Acids Res. 1998 Jun 1; 26(11):2771-8.
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      190. Milliner DS, Wilson DM, Smith LH. Clinical expression and long-term outcomes of primary hyperoxaluria types 1 and 2. J Nephrol. 1998 Mar-Apr; 11 Suppl 1:56-9.
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      191. Melton LJ, Crowson CS, Khosla S, Wilson DM, O'Fallon WM. Fracture risk among patients with urolithiasis: a population-based cohort study. Kidney Int. 1998 Feb; 53(2):459-64.
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      192. Harrison L, Ascione AG, Takiguchi Y, Wilson DM, Chen DJ, Demple B. Comparison of the promoters of the mouse (APEX) and human (APE) apurinic endonuclease genes. Mutat Res. 1997 Dec; 385(3):159-72.
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      193. Wilson DM, Thompson LH. Life without DNA repair. Proc Natl Acad Sci U S A. 1997 Nov 25; 94(24):12754-7.
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      194. Wilson DM, Bergert JH, Larson TS, Liedtke RR. GFR determined by nonradiolabeled iothalamate using capillary electrophoresis. Am J Kidney Dis. 1997 Nov; 30(5):646-52.
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      195. Bergert JH, Liedtke RR, Oda RP, Landers JP, Wilson DM. Development of a nonisotopic capillary electrophoresis-based method for measuring glomerular filtration rate. Electrophoresis. 1997 Sep; 18(10):1827-35.
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      196. Torres VE, Bengal RJ, Litwiller RD, Wilson DM. Aggravation of polycystic kidney disease in Han:SPRD rats by buthionine sulfoximine. J Am Soc Nephrol. 1997 Aug; 8(8):1283-91.
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      197. Cheng SS, Wilson DM, Munn SR. Predictors of progression of diabetic nephropathy: implication for timing of kidney transplantation. Clin Transplant. 1997 Aug; 11(4):334-6.
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      198. Bennett RA, Wilson DM, Wong D, Demple B. Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway. Proc Natl Acad Sci U S A. 1997 Jul 8; 94(14):7166-9.
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      199. Kim JJ, Bagarazzi ML, Trivedi N, Hu Y, Kazahaya K, Wilson DM, Ciccarelli R, Chattergoon MA, Dang K, Mahalingam S, Chalian AA, Agadjanyan MG, Boyer JD, Wang B, Weiner DB. Engineering of in vivo immune responses to DNA immunization via codelivery of costimulatory molecule genes. Nat Biotechnol. 1997 Jul; 15(7):641-6.
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      200. Suh D, Wilson DM, Povirk LF. 3'-phosphodiesterase activity of human apurinic/apyrimidinic endonuclease at DNA double-strand break ends. Nucleic Acids Res. 1997 Jun 15; 25(12):2495-500.
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      201. Demple B, Harrison L, Wilson DM, Bennett RA, Takagi T, Ascione AG. Regulation of eukaryotic abasic endonucleases and their role in genetic stability. Environ Health Perspect. 1997 Jun; 105 Suppl 4:931-4.
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      202. Salhany KE, Feldman M, Kahn MJ, Peritt D, Schretzenmair RD, Wilson DM, DiPaola RS, Glick AD, Kant JA, Nowell PC, Kamoun M. Hepatosplenic gammadelta T-cell lymphoma: ultrastructural, immunophenotypic, and functional evidence for cytotoxic T lymphocyte differentiation. Hum Pathol. 1997 Jun; 28(6):674-85.
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      203. Wilson DM, Ferko AP, Barbieri EJ, DiGregorio GJ, Bobyock E, McMichael R. The interaction of dopamine, cocaine, and cocaethylene with ethanol on central nervous system depression in mice. Pharmacol Biochem Behav. 1997 May-Jun; 57(1-2):73-80.
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      204. Wilson DM, Takeshita M, Demple B. Abasic site binding by the human apurinic endonuclease, Ape, and determination of the DNA contact sites. Nucleic Acids Res. 1997 Mar 1; 25(5):933-9.
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      205. Pearson DA. Thrombus imaging using technetium-99m-labeled high-potency GPIIb/IIIa receptor antagonists. Chemistry and initial biological studies. J Med Chem. 1996 Mar 29; 39(7):1372-82.
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      206. Pearson DA, Lister-James J, McBride WJ, Wilson DM, Martel LJ, Civitello ER, Taylor JE, Moyer BR, Dean RT. Somatostatin receptor-binding peptides labeled with technetium-99m: chemistry and initial biological studies. J Med Chem. 1996 Mar 29; 39(7):1361-71.
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      207. Olney RC, Tsuchiya K, Wilson DM, Mohtai M, Maloney WJ, Schurman DJ, Smith RL. Chondrocytes from osteoarthritic cartilage have increased expression of insulin-like growth factor I (IGF-I) and IGF-binding protein-3 (IGFBP-3) and -5, but not IGF-II or IGFBP-4. J Clin Endocrinol Metab. 1996 Mar; 81(3):1096-103.
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      208. Anderson WF, Holbrook CC, Wilson DM. Development of greenhouse screening for resistance to Aspergillus parasiticus infection and preharvest aflatoxin contamination in peanut. Mycopathologia. 1996; 135(2):115-8.
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      209. Wilson DM, Bennett RA, Marquis JC, Ansari P, Demple B. Trans-complementation by human apurinic endonuclease (Ape) of hypersensitivity to DNA damage and spontaneous mutator phenotype in apn1-yeast. Nucleic Acids Res. 1995 Dec 25; 23(24):5027-33.
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      210. McKane WR, Khosla S, Burritt MF, Kao PC, Wilson DM, Ory SJ, Riggs BL. Mechanism of renal calcium conservation with estrogen replacement therapy in women in early postmenopause--a clinical research center study. J Clin Endocrinol Metab. 1995 Dec; 80(12):3458-64.
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      211. Clarke BL, Wynne AG, Wilson DM, Fitzpatrick LA. Osteomalacia associated with adult Fanconi's syndrome: clinical and diagnostic features. Clin Endocrinol (Oxf). 1995 Oct; 43(4):479-90.
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      212. Wilson DM, Takeshita M, Grollman AP, Demple B. Incision activity of human apurinic endonuclease (Ape) at abasic site analogs in DNA. J Biol Chem. 1995 Jul 7; 270(27):16002-7.
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      213. Neely EK, Hintz RL, Wilson DM, Lee PA, Gautier T, Argente J, Stene M. Normal ranges for immunochemiluminometric gonadotropin assays. J Pediatr. 1995 Jul; 127(1):40-6.
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      214. Wilson DM, King JK. Production of aflatoxins B1, B2, G1, and G2 in pure and mixed cultures of Aspergillus parasiticus and Aspergillus flavus. Food Addit Contam. 1995 May-Jun; 12(3):521-5.
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      215. Olney RC, Anhalt H, Neely EK, Wilson DM. A quantitative assay for IGF-I and IGF binding protein mRNAs: expression in malignant melanoma cells. Mol Cell Endocrinol. 1995 Apr 28; 110(1-2):213-23.
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      216. Trucksess MW, Stoloff L, Brumley WC, Wilson DM, Hale OM, Sangster LT, Miller DM. Aflatoxicol and aflatoxins B1 and M1 in the tissues of pigs receiving aflatoxin. J Assoc Off Anal Chem. 1982 Jul; 65(4):884-7.
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