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Davide Ruggero, PhD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentUrology
Address1450 3rd Street
San Francisco CA 94158
Phone415-514-9755
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    Collapse Research 
    Collapse Research Activities and Funding
    MYCN, mTOR and translation control in medulloblastoma
    NIH/NINDS R01NS089868Sep 1, 2014 - Jun 30, 2019
    Role: Principal Investigator
    X-linked Dyskeratosis Congenita and ribosomal frameshifting
    NIH/NHLBI R01HL119439Aug 1, 2014 - Apr 30, 2018
    Role: Co-Principal Investigator
    elF4E-Dependent Translation Control in the Oncogenic Stress Response and Cancer
    NIH/NCI R01CA184624May 1, 2014 - Apr 30, 2019
    Role: Principal Investigator
    Deciphering the role of the translational oncogenic program in Prostate Cancer
    NIH/NCI R01CA154916Sep 1, 2011 - Jun 30, 2022
    Role: Principal Investigator
    Delineating the Mechanisms Responsible for Synthetic Lethality in MYC-induced Tumorigenesis Driven by Control of Protein Synthesis
    NIH/NCI R01CA140456Jul 1, 2009 - Apr 30, 2020
    Role: Principal Investigator
    Role of ribosome impairments in X-linked Dyskeratosis Congenita pathogenesis
    NIH/NIDDK R01DK098057Aug 1, 2006 - Jun 30, 2016
    Role: Principal Investigator
    Role of rRNA Modifications in Dyskeratosis Congenita and Translation Control
    NIH/NHLBI R01HL085572Aug 1, 2006 - Jun 30, 2011
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator

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    Collapse Global Health

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Truillet C, Cunningham JT, Parker MF, Huynh LT, Conn CS, Ruggero D, Lewis JS, Evans MJ. Non-invasive measurement of mTORC1 signaling with 89Zr-transferrin. Clin Cancer Res. 2016 Dec 22. PMID: 28007777.
      View in: PubMed
    2. So L, Lee J, Palafox M, Mallya S, Woxland CG, Arguello M, Truitt ML, Sonenberg N, Ruggero D, Fruman DA. The 4E-BP-eIF4E axis promotes rapamycin-sensitive growth and proliferation in lymphocytes. Sci Signal. 2016; 9(430):ra57. PMID: 27245614.
      View in: PubMed
    3. Truitt ML, Ruggero D. New frontiers in translational control of the cancer genome. Nat Rev Cancer. 2016 Apr 26; 16(5):288-304. PMID: 27112207.
      View in: PubMed
    4. Hsieh AC, Nguyen HG, Wen L, Edlind MP, Carroll PR, Kim W, Ruggero D. Cell type-specific abundance of 4EBP1 primes prostate cancer sensitivity or resistance to PI3K pathway inhibitors. Sci Signal. 2015; 8(403):ra116. PMID: 26577921.
      View in: PubMed
    5. Truitt ML, Conn CS, Shi Z, Pang X, Tokuyasu T, Coady AM, Seo Y, Barna M, Ruggero D. Differential Requirements for eIF4E Dose in Normal Development and Cancer. Cell. 2015 Jul 2; 162(1):59-71. PMID: 26095252; PMCID: PMC4491046 [Available on 07/02/16].
    6. Fujita-Sato S, Galeas J, Truitt M, Pitt C, Urisman A, Bandyopadhyay S, Ruggero D, McCormick F. Enhanced MET Translation and Signaling Sustains K-Ras-Driven Proliferation under Anchorage-Independent Growth Conditions. Cancer Res. 2015 Jul 15; 75(14):2851-62. PMID: 25977330; PMCID: PMC4506276 [Available on 07/15/16].
    7. Sheridan CM, Grogan TR, Nguyen HG, Galet C, Rettig MB, Hsieh AC, Ruggero D. YB-1 and MTA1 protein levels and not DNA or mRNA alterations predict for prostate cancer recurrence. Oncotarget. 2015 Apr 10; 6(10):7470-80. PMID: 25797255; PMCID: PMC4480693.
    8. Pelletier J, Graff J, Ruggero D, Sonenberg N. Targeting the eIF4F translation initiation complex: a critical nexus for cancer development. Cancer Res. 2015 Jan 15; 75(2):250-63. PMID: 25593033; PMCID: PMC4299928 [Available on 01/15/16].
    9. McMahon M, Contreras A, Ruggero D. Small RNAs with big implications: new insights into H/ACA snoRNA function and their role in human disease. Wiley Interdiscip Rev RNA. 2015 Mar-Apr; 6(2):173-89. PMID: 25363811; PMCID: PMC4390053 [Available on 03/01/16].
    10. Ruggero D, Shimamura A. Marrow failure: a window into ribosome biology. Blood. 2014 Oct 30; 124(18):2784-92. PMID: 25237201; PMCID: PMC4215310.
    11. Cunningham JT, Moreno MV, Lodi A, Ronen SM, Ruggero D. Protein and nucleotide biosynthesis are coupled by a single rate-limiting enzyme, PRPS2, to drive cancer. Cell. 2014 May 22; 157(5):1088-103. PMID: 24855946; PMCID: PMC4140650.
    12. Barna M, Ruggero D. Tailor made protein synthesis for HSCs. Cell Stem Cell. 2014 Apr 3; 14(4):423-4. PMID: 24702992; PMCID: PMC4071939.
    13. Han K, Jaimovich A, Dey G, Ruggero D, Meyuhas O, Sonenberg N, Meyer T. Parallel measurement of dynamic changes in translation rates in single cells. Nat Methods. 2014 Jan; 11(1):86-93. PMID: 24213167; PMCID: PMC4039304.
    14. Stumpf CR, Moreno MV, Olshen AB, Taylor BS, Ruggero D. The translational landscape of the mammalian cell cycle. Mol Cell. 2013 Nov 21; 52(4):574-82. PMID: 24120665; PMCID: PMC3959127.
    15. Cunningham JT, Ruggero D. New connections between old pathways: PDK1 signaling promotes cellular transformation through PLK1-dependent MYC stabilization. Cancer Discov. 2013 Oct; 3(10):1099-102. PMID: 24124229; PMCID: PMC3857155.
    16. Olshen AB, Hsieh AC, Stumpf CR, Olshen RA, Ruggero D, Taylor BS. Assessing gene-level translational control from ribosome profiling. Bioinformatics. 2013 Dec 1; 29(23):2995-3002. PMID: 24048356; PMCID: PMC3834798.
    17. Pourdehnad M, Truitt ML, Siddiqi IN, Ducker GS, Shokat KM, Ruggero D. Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers. Proc Natl Acad Sci U S A. 2013 Jul 16; 110(29):11988-93. PMID: 23803853; PMCID: PMC3718086.
    18. Bellodi C, McMahon M, Contreras A, Juliano D, Kopmar N, Nakamura T, Maltby D, Burlingame A, Savage SA, Shimamura A, Ruggero D. H/ACA small RNA dysfunctions in disease reveal key roles for noncoding RNA modifications in hematopoietic stem cell differentiation. Cell Rep. 2013 May 30; 3(5):1493-502. PMID: 23707062; PMCID: PMC3857015.
    19. Allenspach EJ, Bellodi C, Jeong D, Kopmar N, Nakamura T, Ochs HD, Ruggero D, Skoda-Smith S, Shimamura A, Torgerson TR. Common variable immunodeficiency as the initial presentation of dyskeratosis congenita. J Allergy Clin Immunol. 2013 Jul; 132(1):223-6. PMID: 23403051; PMCID: PMC4560355.
    20. Ruggero D. Translational control in cancer etiology. Cold Spring Harb Perspect Biol. 2013 Feb; 5(2). PMID: 22767671; PMCID: PMC3552512.
    21. Cunningham JT, Pourdehnad M, Stumpf CR, Ruggero D. Investigating Myc-dependent translational regulation in normal and cancer cells. Methods Mol Biol. 2013; 1012:201-12. PMID: 24006066; PMCID: PMC4390065.
    22. Santini E, Huynh TN, MacAskill AF, Carter AG, Pierre P, Ruggero D, Kaphzan H, Klann E. Exaggerated translation causes synaptic and behavioural aberrations associated with autism. Nature. 2013 Jan 17; 493(7432):411-5. PMID: 23263185; PMCID: PMC3548017.
    23. Gkogkas CG, Khoutorsky A, Ran I, Rampakakis E, Nevarko T, Weatherill DB, Vasuta C, Yee S, Truitt M, Dallaire P, Major F, Lasko P, Ruggero D, Nader K, Lacaille JC, Sonenberg N. Autism-related deficits via dysregulated eIF4E-dependent translational control. Nature. 2013 Jan 17; 493(7432):371-7. PMID: 23172145; PMCID: PMC4133997.
    24. Hart LS, Cunningham JT, Datta T, Dey S, Tameire F, Lehman SL, Qiu B, Zhang H, Cerniglia G, Bi M, Li Y, Gao Y, Liu H, Li C, Maity A, Thomas-Tikhonenko A, Perl AE, Koong A, Fuchs SY, Diehl JA, Mills IG, Ruggero D, Koumenis C. ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth. J Clin Invest. 2012 Dec; 122(12):4621-34. PMID: 23143306; PMCID: PMC3533536.
    25. Upton JP, Wang L, Han D, Wang ES, Huskey NE, Lim L, Truitt M, McManus MT, Ruggero D, Goga A, Papa FR, Oakes SA. IRE1a cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2. Science. 2012 Nov 9; 338(6108):818-22. PMID: 23042294; PMCID: PMC3742121.
    26. Ruggero D. Revisiting the nucleolus: from marker to dynamic integrator of cancer signaling. Sci Signal. 2012; 5(241):pe38. PMID: 22969157; PMCID: PMC4390046.
    27. Hsieh AC, Liu Y, Edlind MP, Ingolia NT, Janes MR, Sher A, Shi EY, Stumpf CR, Christensen C, Bonham MJ, Wang S, Ren P, Martin M, Jessen K, Feldman ME, Weissman JS, Shokat KM, Rommel C, Ruggero D. The translational landscape of mTOR signalling steers cancer initiation and metastasis. Nature. 2012 May 3; 485(7396):55-61. PMID: 22367541; PMCID: PMC3663483.
    28. Jack K, Bellodi C, Landry DM, Niederer RO, Meskauskas A, Musalgaonkar S, Kopmar N, Krasnykh O, Dean AM, Thompson SR, Ruggero D, Dinman JD. rRNA pseudouridylation defects affect ribosomal ligand binding and translational fidelity from yeast to human cells. Mol Cell. 2011 Nov 18; 44(4):660-6. PMID: 22099312; PMCID: PMC3222873.
    29. Hsieh AC, Truitt ML, Ruggero D. Oncogenic AKTivation of translation as a therapeutic target. Br J Cancer. 2011 Jul 26; 105(3):329-36. PMID: 21772331; PMCID: PMC3172900.
    30. Stumpf CR, Ruggero D. The cancerous translation apparatus. Curr Opin Genet Dev. 2011 Aug; 21(4):474-83. PMID: 21543223; PMCID: PMC3481834.
    31. Hsieh AC, Ruggero D. Targeting eukaryotic translation initiation factor 4E (eIF4E) in cancer. Clin Cancer Res. 2010 Oct 15; 16(20):4914-20. PMID: 20702611.
      View in: PubMed
    32. Bellodi C, Krasnykh O, Haynes N, Theodoropoulou M, Peng G, Montanaro L, Ruggero D. Loss of function of the tumor suppressor DKC1 perturbs p27 translation control and contributes to pituitary tumorigenesis. Cancer Res. 2010 Jul 15; 70(14):6026-35. PMID: 20587522; PMCID: PMC2913864.
    33. Bellodi C, Kopmar N, Ruggero D. Deregulation of oncogene-induced senescence and p53 translational control in X-linked dyskeratosis congenita. EMBO J. 2010 Jun 2; 29(11):1865-76. PMID: 20453831; PMCID: PMC2885924.
    34. Hsieh AC, Costa M, Zollo O, Davis C, Feldman ME, Testa JR, Meyuhas O, Shokat KM, Ruggero D. Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E. Cancer Cell. 2010 Mar 16; 17(3):249-61. PMID: 20227039; PMCID: PMC2901095.
    35. Ruggero D. The role of Myc-induced protein synthesis in cancer. Cancer Res. 2009 Dec 1; 69(23):8839-43. PMID: 19934336; PMCID: PMC2880919.
    36. Feldman ME, Apsel B, Uotila A, Loewith R, Knight ZA, Ruggero D, Shokat KM. Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. PLoS Biol. 2009 Feb 10; 7(2):e38. PMID: 19209957; PMCID: PMC2637922.
    37. Barna M, Pusic A, Zollo O, Costa M, Kondrashov N, Rego E, Rao PH, Ruggero D. Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency. Nature. 2008 Dec 18; 456(7224):971-5. PMID: 19011615; PMCID: PMC2880952.
    38. Yoon A, Peng G, Brandenburger Y, Brandenburg Y, Zollo O, Xu W, Rego E, Ruggero D. Impaired control of IRES-mediated translation in X-linked dyskeratosis congenita. Science. 2006 May 12; 312(5775):902-6. PMID: 16690864.
      View in: PubMed
    39. Rego EM, Ruggero D, Tribioli C, Cattoretti G, Kogan S, Redner RL, Pandolfi PP. Leukemia with distinct phenotypes in transgenic mice expressing PML/RAR alpha, PLZF/RAR alpha or NPM/RAR alpha. Oncogene. 2006 Mar 23; 25(13):1974-9. PMID: 16331271.
      View in: PubMed
    40. Kaplan RN, Riba RD, Zacharoulis S, Bramley AH, Vincent L, Costa C, MacDonald DD, Jin DK, Shido K, Kerns SA, Zhu Z, Hicklin D, Wu Y, Port JL, Altorki N, Port ER, Ruggero D, Shmelkov SV, Jensen KK, Rafii S, Lyden D. VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature. 2005 Dec 8; 438(7069):820-7. PMID: 16341007; PMCID: PMC2945882.
    41. Ruggero D, Sonenberg N. The Akt of translational control. Oncogene. 2005 Nov 14; 24(50):7426-34. PMID: 16288289.
      View in: PubMed
    42. Ruggero D, Montanaro L, Ma L, Xu W, Londei P, Cordon-Cardo C, Pandolfi PP. The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis. Nat Med. 2004 May; 10(5):484-6. PMID: 15098029.
      View in: PubMed
    43. Ruggero D, Pandolfi PP. Does the ribosome translate cancer? Nat Rev Cancer. 2003 Mar; 3(3):179-92. PMID: 12612653.
      View in: PubMed
    44. Ruggero D, Grisendi S, Piazza F, Rego E, Mari F, Rao PH, Cordon-Cardo C, Pandolfi PP. Dyskeratosis congenita and cancer in mice deficient in ribosomal RNA modification. Science. 2003 Jan 10; 299(5604):259-62. PMID: 12522253.
      View in: PubMed
    45. Barna M, Merghoub T, Costoya JA, Ruggero D, Branford M, Bergia A, Samori B, Pandolfi PP. Plzf mediates transcriptional repression of HoxD gene expression through chromatin remodeling. Dev Cell. 2002 Oct; 3(4):499-510. PMID: 12408802.
      View in: PubMed
    46. Ruggero D, Wang ZG, Pandolfi PP. The puzzling multiple lives of PML and its role in the genesis of cancer. Bioessays. 2000 Sep; 22(9):827-35. PMID: 10944585.
      View in: PubMed
    47. Zhong S, Salomoni P, Ronchetti S, Guo A, Ruggero D, Pandolfi PP. Promyelocytic leukemia protein (PML) and Daxx participate in a novel nuclear pathway for apoptosis. J Exp Med. 2000 Feb 21; 191(4):631-40. PMID: 10684855; PMCID: PMC2195846.
    48. Condò I, Ciammaruconi A, Benelli D, Ruggero D, Londei P. Cis-acting signals controlling translational initiation in the thermophilic archaeon Sulfolobus solfataricus. Mol Microbiol. 1999 Oct; 34(2):377-84. PMID: 10564480.
      View in: PubMed
    49. Wang ZG, Ruggero D, Ronchetti S, Zhong S, Gaboli M, Rivi R, Pandolfi PP. PML is essential for multiple apoptotic pathways. Nat Genet. 1998 Nov; 20(3):266-72. PMID: 9806545.
      View in: PubMed
    50. Condò I, Ruggero D, Reinhardt R, Londei P. A novel aminopeptidase associated with the 60 kDa chaperonin in the thermophilic archaeon Sulfolobus solfataricus. Mol Microbiol. 1998 Aug; 29(3):775-85. PMID: 9723917.
      View in: PubMed
    51. Ruggero D, Ciammaruconi A, Londei P. The chaperonin of the archaeon Sulfolobus solfataricus is an RNA-binding protein that participates in ribosomal RNA processing. EMBO J. 1998 Jun 15; 17(12):3471-7. PMID: 9628882; PMCID: PMC1170683.
    52. Ruggero D, Londei P. Differential antibiotic sensitivity determined by the large ribosomal subunit in thermophilic archaea. J Bacteriol. 1996 Jun; 178(11):3396-8. PMID: 8655531; PMCID: PMC178103.
    53. Bandini G, Ricci P, Ruggero D, Cantore M, Visani G, Tura S. Lithium and granulocytopenia during induction treatment of adult acute lymphoblastic leukemia. Tumori. 1982 Oct 31; 68(5):427-30. PMID: 6960590.
      View in: PubMed
    54. Speck B, Gratwohl A, Nissen C, Leibundgut U, Ruggero D, Osterwalder B, Burri HP, Cornu P, Jeannet M. Treatment of severe aplastic anaemia with antilymphocyte globulin or bone-marrow transplantation. Br Med J (Clin Res Ed). 1981 Mar 14; 282(6267):860-3. PMID: 6783204; PMCID: PMC1504686.
    55. Gratwohl A, Cornu P, Nissen C, Ruggero D, Osterwalder B, Speck B. [Experience with intensive plasma exchange]. Schweiz Med Wochenschr. 1980 Oct 4; 110(40):1449-51. PMID: 7280593.
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    56. Bandini G, Ricci P, Baccarani M, Ruggero D, Tura S. Serum lysozyme level in adult acute non-lymphoid leukaemia. Haematologica. 1979 Jun; 64(3):288-95. PMID: 113297.
      View in: PubMed
    57. Ruggero D, Baccarani M, Gobbi M, Tura S. Adult acute lymphoblastic leukaemia: study of 32 patients and analysis of prognostic factors. Scand J Haematol. 1979 Feb; 22(2):154-64. PMID: 311937.
      View in: PubMed
    58. Baccarani M, Ruggero D, Gobbi M, Tura S. Sex and prognosis in adult acute lymphoblastic leukaemia. Br Med J. 1978 Dec 9; 2(6152):1646. PMID: 281982; PMCID: PMC1608841.
    59. Zaccaria A, Ruggero D, Guolo ML, Guarini A, Frezza R, Baccarani M, Tura S. Ph1-positive chronic myeloid leukaemia presenting in blastic crisis: report of 12 cases. Boll Ist Sieroter Milan. 1978 Jul 31; 57(3):383-91. PMID: 282907.
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    60. Baccarani M, Ruggero D, Tura S. Therapy of chronic myeloid leukemia (CML): interim report on protocols CML/73 and CML/74. Boll Ist Sieroter Milan. 1978 Jul 31; 57(3):278-88. PMID: 367386.
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    61. Gobbi M, Ruggero D, Baccarani M, Zaccaria A, Tomasini I, Tura S. Immunotherapy with BCG and leukemic blast cells during complete remission of acute myeloid leukemia. Haematologica. 1977 Oct; 62(5):529-36. PMID: 412739.
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    62. Ruggero D, Baccarani M, Zaccaria A, Gobbi M, Tomasini I, Tura S. Nervous system involvement in adult acute myeloid leukaemia: report of five cases. Haematologica. 1977 Jun; 62(3):312-9. PMID: 408244.
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    63. Gobbi M, Fiacchini M, Tomasini I, Ruggero D, Lauria F, Tura S. Immunological study of patients with Hodgkin's disease in long-lasting not-maintained complete remission. Boll Ist Sieroter Milan. 1977 Mar 31; 56(2):144-51. PMID: 326273.
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    64. Ruggero D, Baccarani M, Guarini A, Gugliotta L, Gobbi M, Ricci P, Zaccaria A, Lauria F, Tomasini I, Fiacchini M, Santucci MA, Tura S. Acute promyelocytic leukemia: results of therapy and analysis of 13 cases. Acta Haematol. 1977; 58(2):108-19. PMID: 409019.
      View in: PubMed
    65. Ruggero D, Baccarani M, Tomasini I, Gobbi M, Santucci MA, Guarini A, Tura S. [Progress and problems in the treatment of acute myeloid leukemia: analysis of 92 cases]. G Clin Med. 1976 Sep-Oct; 57(9-10):283-97. PMID: 1072018.
      View in: PubMed
    66. Fiacchini M, Ruggero D, Tomasini I, Sciascia R, Emiliani E, Babini L. ["Cured" Hodgkin's disease in a retrospective study of 147 cases]. G Clin Med. 1976 Mar-Aug; 57(5-6):167-82. PMID: 1010166.
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    67. Tura S, Ruggero D. [Antibiotic therapy in the high risk patient (hematologic study)]. G Clin Med. 1976 Mar-Apr; 57(3-4):92-104. PMID: 1001857.
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    68. Baccarani M, Zaccaria A, Santucci AM, Bagnara GP, Ricci P, Gobbi M, Ruggero D, Brunelli MA, Tura S. A simultaneous study of bone marrow, spleen, and liver in chronic myeloid leukemia: evidence for differences in cell composition and karyotypes. Ser Haematol. 1975; 8(4):81-112. PMID: 1071286.
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