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    Davide Ruggero, PhD

    TitleAssociate Professor in Residence
    SchoolUCSF School of Medicine
    DepartmentUrology
    Address1450 3rd Street
    San Francisco CA 94158
    Phone415-514-9755

       Bibliographic 
       Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Bellodi C, McMahon M, Contreras A, Juliano D, Kopmar N, Nakamura T, Maltby D, Burlingame A, Savage SA, Shimamura A, Ruggero D. H/ACA Small RNA Dysfunctions in Disease Reveal Key Roles for Noncoding RNA Modifications in Hematopoietic Stem Cell Differentiation. Cell Rep. 2013 May 30; 3(5):1493-502.
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      2. Ruggero D. Translational control in cancer etiology. Cold Spring Harb Perspect Biol. 2013; 5(2).
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      3. Santini E, Huynh TN, MacAskill AF, Carter AG, Pierre P, Ruggero D, Kaphzan H, Klann E. Exaggerated translation causes synaptic and behavioural aberrations associated with autism. Nature. 2013 Jan 17; 493(7432):411-5.
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      4. Gkogkas CG, Khoutorsky A, Ran I, Rampakakis E, Nevarko T, Weatherill DB, Vasuta C, Yee S, Truitt M, Dallaire P, Major F, Lasko P, Ruggero D, Nader K, Lacaille JC, Sonenberg N. Autism-related deficits via dysregulated eIF4E-dependent translational control. Nature. 2013 Jan 17; 493(7432):371-7.
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      5. Hart LS, Cunningham JT, Datta T, Dey S, Tameire F, Lehman SL, Qiu B, Zhang H, Cerniglia G, Bi M, Li Y, Gao Y, Liu H, Li C, Maity A, Thomas-Tikhonenko A, Perl AE, Koong A, Fuchs SY, Diehl JA, Mills IG, Ruggero D, Koumenis C. ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth. J Clin Invest. 2012 Dec 3; 122(12):4621-34.
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      6. Upton JP, Wang L, Han D, Wang ES, Huskey NE, Lim L, Truitt M, McManus MT, Ruggero D, Goga A, Papa FR, Oakes SA. IRE1a cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2. Science. 2012 Nov 9; 338(6108):818-22.
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      7. Ruggero D. Revisiting the nucleolus: from marker to dynamic integrator of cancer signaling. Sci Signal. 2012; 5(241):pe38.
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      8. Hsieh AC, Liu Y, Edlind MP, Ingolia NT, Janes MR, Sher A, Shi EY, Stumpf CR, Christensen C, Bonham MJ, Wang S, Ren P, Martin M, Jessen K, Feldman ME, Weissman JS, Shokat KM, Rommel C, Ruggero D. The translational landscape of mTOR signalling steers cancer initiation and metastasis. Nature. 2012 May 3; 485(7396):55-61.
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      9. Jack K, Bellodi C, Landry DM, Niederer RO, Meskauskas A, Musalgaonkar S, Kopmar N, Krasnykh O, Dean AM, Thompson SR, Ruggero D, Dinman JD. rRNA pseudouridylation defects affect ribosomal ligand binding and translational fidelity from yeast to human cells. Mol Cell. 2011 Nov 18; 44(4):660-6.
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      10. Hsieh AC, Truitt ML, Ruggero D. Oncogenic AKTivation of translation as a therapeutic target. Br J Cancer. 2011 Jul 26; 105(3):329-36.
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      11. Stumpf CR, Ruggero D. The cancerous translation apparatus. Curr Opin Genet Dev. 2011 Aug; 21(4):474-83.
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      12. Hsieh AC, Ruggero D. Targeting eukaryotic translation initiation factor 4E (eIF4E) in cancer. Clin Cancer Res. 2010 Oct 15; 16(20):4914-20.
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      13. Bellodi C, Krasnykh O, Haynes N, Theodoropoulou M, Peng G, Montanaro L, Ruggero D. Loss of function of the tumor suppressor DKC1 perturbs p27 translation control and contributes to pituitary tumorigenesis. Cancer Res. 2010 Jul 15; 70(14):6026-35.
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      14. Bellodi C, Kopmar N, Ruggero D. Deregulation of oncogene-induced senescence and p53 translational control in X-linked dyskeratosis congenita. EMBO J. 2010 Jun 2; 29(11):1865-76.
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      15. Hsieh AC, Costa M, Zollo O, Davis C, Feldman ME, Testa JR, Meyuhas O, Shokat KM, Ruggero D. Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E. Cancer Cell. 2010 Mar 16; 17(3):249-61.
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      16. Ruggero D. The role of Myc-induced protein synthesis in cancer. Cancer Res. 2009 Dec 1; 69(23):8839-43.
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      17. Feldman ME, Apsel B, Uotila A, Loewith R, Knight ZA, Ruggero D, Shokat KM. Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. PLoS Biol. 2009 Feb 10; 7(2):e38.
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      18. Barna M, Pusic A, Zollo O, Costa M, Kondrashov N, Rego E, Rao PH, Ruggero D. Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency. Nature. 2008 Dec 18; 456(7224):971-5.
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      19. Yoon A, Peng G, Brandenburger Y, Brandenburg Y, Zollo O, Xu W, Rego E, Ruggero D. Impaired control of IRES-mediated translation in X-linked dyskeratosis congenita. Science. 2006 May 12; 312(5775):902-6.
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      20. Rego EM, Ruggero D, Tribioli C, Cattoretti G, Kogan S, Redner RL, Pandolfi PP. Leukemia with distinct phenotypes in transgenic mice expressing PML/RAR alpha, PLZF/RAR alpha or NPM/RAR alpha. Oncogene. 2006 Mar 23; 25(13):1974-9.
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      21. Kaplan RN, Riba RD, Zacharoulis S, Bramley AH, Vincent L, Costa C, MacDonald DD, Jin DK, Shido K, Kerns SA, Zhu Z, Hicklin D, Wu Y, Port JL, Altorki N, Port ER, Ruggero D, Shmelkov SV, Jensen KK, Rafii S, Lyden D. VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature. 2005 Dec 8; 438(7069):820-7.
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      22. Ruggero D, Sonenberg N. The Akt of translational control. Oncogene. 2005 Nov 14; 24(50):7426-34.
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      23. Ruggero D, Montanaro L, Ma L, Xu W, Londei P, Cordon-Cardo C, Pandolfi PP. The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis. Nat Med. 2004 May; 10(5):484-6.
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      24. Ruggero D, Pandolfi PP. Does the ribosome translate cancer? Nat Rev Cancer. 2003 Mar; 3(3):179-92.
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      25. Ruggero D, Grisendi S, Piazza F, Rego E, Mari F, Rao PH, Cordon-Cardo C, Pandolfi PP. Dyskeratosis congenita and cancer in mice deficient in ribosomal RNA modification. Science. 2003 Jan 10; 299(5604):259-62.
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      26. Barna M, Merghoub T, Costoya JA, Ruggero D, Branford M, Bergia A, Samori B, Pandolfi PP. Plzf mediates transcriptional repression of HoxD gene expression through chromatin remodeling. Dev Cell. 2002 Oct; 3(4):499-510.
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      27. Ruggero D, Wang ZG, Pandolfi PP. The puzzling multiple lives of PML and its role in the genesis of cancer. Bioessays. 2000 Sep; 22(9):827-35.
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      28. Zhong S, Salomoni P, Ronchetti S, Guo A, Ruggero D, Pandolfi PP. Promyelocytic leukemia protein (PML) and Daxx participate in a novel nuclear pathway for apoptosis. J Exp Med. 2000 Feb 21; 191(4):631-40.
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      29. Condò I, Ciammaruconi A, Benelli D, Ruggero D, Londei P. Cis-acting signals controlling translational initiation in the thermophilic archaeon Sulfolobus solfataricus. Mol Microbiol. 1999 Oct; 34(2):377-84.
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      30. Wang ZG, Ruggero D, Ronchetti S, Zhong S, Gaboli M, Rivi R, Pandolfi PP. PML is essential for multiple apoptotic pathways. Nat Genet. 1998 Nov; 20(3):266-72.
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      31. Condò I, Ruggero D, Reinhardt R, Londei P. A novel aminopeptidase associated with the 60 kDa chaperonin in the thermophilic archaeon Sulfolobus solfataricus. Mol Microbiol. 1998 Aug; 29(3):775-85.
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      32. Ruggero D, Ciammaruconi A, Londei P. The chaperonin of the archaeon Sulfolobus solfataricus is an RNA-binding protein that participates in ribosomal RNA processing. EMBO J. 1998 Jun 15; 17(12):3471-7.
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      33. Ruggero D, Londei P. Differential antibiotic sensitivity determined by the large ribosomal subunit in thermophilic archaea. J Bacteriol. 1996 Jun; 178(11):3396-8.
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      34. Bandini G, Ricci P, Ruggero D, Cantore M, Visani G, Tura S. Lithium and granulocytopenia during induction treatment of adult acute lymphoblastic leukemia. Tumori. 1982 Oct 31; 68(5):427-30.
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      35. Speck B, Gratwohl A, Nissen C, Leibundgut U, Ruggero D, Osterwalder B, Burri HP, Cornu P, Jeannet M. Treatment of severe aplastic anaemia with antilymphocyte globulin or bone-marrow transplantation. Br Med J (Clin Res Ed). 1981 Mar 14; 282(6267):860-3.
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      36. Gratwohl A, Cornu P, Nissen C, Ruggero D, Osterwalder B, Speck B. [Experience with intensive plasma exchange]. Schweiz Med Wochenschr. 1980 Oct 4; 110(40):1449-51.
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      37. Bandini G, Ricci P, Baccarani M, Ruggero D, Tura S. Serum lysozyme level in adult acute non-lymphoid leukaemia. Haematologica. 1979 Jun; 64(3):288-95.
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      38. Ruggero D, Baccarani M, Gobbi M, Tura S. Adult acute lymphoblastic leukaemia: study of 32 patients and analysis of prognostic factors. Scand J Haematol. 1979 Feb; 22(2):154-64.
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      39. Baccarani M, Ruggero D, Gobbi M, Tura S. Sex and prognosis in adult acute lymphoblastic leukaemia. Br Med J. 1978 Dec 9; 2(6152):1646.
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      40. Zaccaria A, Ruggero D, Guolo ML, Guarini A, Frezza R, Baccarani M, Tura S. Ph1-positive chronic myeloid leukaemia presenting in blastic crisis: report of 12 cases. Boll Ist Sieroter Milan. 1978 Jul 31; 57(3):383-91.
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      41. Baccarani M, Ruggero D, Tura S. Therapy of chronic myeloid leukemia (CML): interim report on protocols CML/73 and CML/74. Boll Ist Sieroter Milan. 1978 Jul 31; 57(3):278-88.
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      42. Gobbi M, Ruggero D, Baccarani M, Zaccaria A, Tomasini I, Tura S. Immunotherapy with BCG and leukemic blast cells during complete remission of acute myeloid leukemia. Haematologica. 1977 Oct; 62(5):529-36.
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      43. Ruggero D, Baccarani M, Zaccaria A, Gobbi M, Tomasini I, Tura S. Nervous system involvement in adult acute myeloid leukaemia: report of five cases. Haematologica. 1977 Jun; 62(3):312-9.
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      44. Gobbi M, Fiacchini M, Tomasini I, Ruggero D, Lauria F, Tura S. Immunological study of patients with Hodgkin's disease in long-lasting not-maintained complete remission. Boll Ist Sieroter Milan. 1977 Mar 31; 56(2):144-51.
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      45. Ruggero D, Baccarani M, Guarini A, Gugliotta L, Gobbi M, Ricci P, Zaccaria A, Lauria F, Tomasini I, Fiacchini M, Santucci MA, Tura S. Acute promyelocytic leukemia: results of therapy and analysis of 13 cases. Acta Haematol. 1977; 58(2):108-19.
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      46. Ruggero D, Baccarani M, Tomasini I, Gobbi M, Santucci MA, Guarini A, Tura S. [Progress and problems in the treatment of acute myeloid leukemia: analysis of 92 cases]. G Clin Med. 1976 Sep-Oct; 57(9-10):283-97.
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      47. Fiacchini M, Ruggero D, Tomasini I, Sciascia R, Emiliani E, Babini L. ["Cured" Hodgkin's disease in a retrospective study of 147 cases]. G Clin Med. 1976 Mar-Aug; 57(5-6):167-82.
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      48. Tura S, Ruggero D. [Antibiotic therapy in the high risk patient (hematologic study)]. G Clin Med. 1976 Mar-Apr; 57(3-4):92-104.
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      49. Baccarani M, Zaccaria A, Santucci AM, Bagnara GP, Ricci P, Gobbi M, Ruggero D, Brunelli MA, Tura S. A simultaneous study of bone marrow, spleen, and liver in chronic myeloid leukemia: evidence for differences in cell composition and karyotypes. Ser Haematol. 1975; 8(4):81-112.
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