Deborah Barnes, PhD

SchoolUCSF School of Medicine
Address4150 Clement St
San Francisco CA 94121
Phone415-221-4810 ext. 4221
vCardDownload vCard

    Collapse Biography 
    Collapse Education and Training
    Stanford University, Stanford, CAB.A.06/1988Human Biology
    University of California, Santa Cruz, Santa Cruz, CACertificate06/1991Science Writing
    University of California, Berkeley, Berkeley, CAM.P.H.06/1995Epidemiology & Biostatistics
    University of California, Berkeley, Berkeley, CAPh.D.12/2001Epidemiology
    University of California, San Francisco, San Francisco, CACertificate06/2014Implementation Science
    Collapse Awards and Honors
    Department of Veterans Affairs2017VA Innovators Award
    Clinical and Translational Sciences Institute, UCSF2013Consultant of the Year awardee
    Medical Student Training in Aging Research program2011Mentor of the Year awardee
    Bay Area Clinical Research Symposium2010Mentor of the Year nominee
    National Institute on Aging2005K01 Career Development Award (AG-024069)
    Alzheimer's Association of Northern California and Northern Nevada2003Student Award for Excellence in Alzheimer's Research
    University of California, Berkeley2001Paola Timiras Award for Research on Aging
    National Institute of Mental Health2000National Research Service Award for Individual Predoctoral Fellows (F31 MH12665)

    Collapse Overview 
    Collapse Overview
    Dementia prevalence is expected to triple worldwide over the next 40 years at tremendous monetary and emotional cost. My research is designed to minimize the impact of the impending dementia epidemic by using a three-pronged approach for developing and evaluating strategies to maintain cognitive function and prevent or delay dementia onset in late life. Specifically, my work focuses on identification of risk factors for cognitive impairment and dementia in older adults, development of dementia prediction models that can be used to estimate the impact of risk factor reduction and to target prevention strategies toward those who are at greatest risk and development and evaluation of interventions to delay onset or slow progression of cognitive impairment and dementia.

    Much of my early research focused on performing observational studies to identify factors associated with increased or decreased risk of cognitive decline and dementia. I was particularly interested in the potential protective effects of physical activity, and a major contribution of my work has been the use of objective measures (rather than self-report) to assess physical activity levels in observational studies. In one study, we found that elders with higher levels of cardiorespiratory fitness ? as measured objectively using peak oxygen consumption during exercise treadmill testing ? experienced less cognitive decline over a 6-year follow-up period (Barnes et al, J Am Geriatr Soc 2003). In a second study, we found that older women who moved more during the day ? as measured objectively using wrist actigraphy ? had higher levels of cognitive function and a lower risk of cognitive impairment (Barnes et al., J Am Geriatr Soc 2008). I also am interested in the potential beneficial effects of mental activity on cognitive function in older adults and published an early study demonstrating a strong relationship between literacy and cognitive function (Barnes et al., J Gerontol Med Sci 2004). Our work also has found that depressive symptoms are associated with an increased risk of mild cognitive impairment (Barnes et al., Arch Gen Psychiatry 2006), and I received funding from NARSAD to build on this work by studying the effects of depression over the life course on late-life risk of dementia (Barnes et al., Arch Gen Psychiatry 2012). In addition, we have found that older women who experience long-term maintenance of cognitive function are less likely to have diabetes, hypertension or difficulty with daily activities and more likely to have healthy behaviors and good social networks (Barnes et al., J Am Geriatr Soc 2007) and that older adults who have both high secondhand smoke exposure and carotid artery stenosis are at particularly high risk of dementia (Barnes et al., Am J Epidemiol 2010). In Veterans, we have found that traumatic brain injury (Barnes et al., Neurology 2014) and prisoner of war (POW) status (Meziab et al., Alzheimers Dement 2014) are independent risk factors for dementia. Together, these studies suggest that there are a variety of potential strategies for lowering risk of cognitive impairment and dementia in late life.

    Another major focus of my work has been on development of dementia risk indices that can be used to identify elders with a high dementia risk in different settings as well as risk prediction models to project the potential impact of changes in risk factor profiles. As successful strategies for enhancing cognitive function and preventing dementia are developed, it will be critically important to be able to identify high-risk elders to target for intervention. My first publication in this area (Barnes et al., Neurology 2009) found that a combination of demographic, cognitive, behavioral, functional, medical, genetic, cerebral MRI findings and carotid artery ultrasound measures could be used to predict an individual?s six-year risk of dementia with high accuracy. This publication generated substantial interest from clinicians and researchers world-wide as well as the lay press, including interviews with CBS Evening News, ABC News Online, US News & World Report, and Time. I subsequently was invited to write an editorial about the future role of dementia risk indices (Barnes & Yaffe, Future Neurology 2009) and to present on the risk index approach at the invitation-only Leon Thal Symposium ?09. In a follow-up publication, I found that an abbreviated index that included only items that could be administered quickly without special equipment was almost as accurate as the original index (Barnes et al., Alzheimer?s & Dementia 2010). This line of research led to my involvement with an NIA workgroup that developed a simple Dementia Screening Indicator tool for primary care settings to help identify high-risk elders who should be considered for cognitive screening as part of the new Annual Medicare Wellness Visit, and I was selected to be lead author of the writing group (Barnes et al, Alzheimers Dementia 2014). I also have developed a prediction model to identify older adults with mild cognitive impairment who have an increased risk of progressing to Alzheimer's disease (Barnes et al., Alzheimer's & Dementia 2014). Furthermore, I expanded on this work by projecting the potential impact of risk factor reduction on future dementia prevalence (Barnes and Yaffe, Lancet Neurology 2011; Norton et al, Lancet Neurology 2014). We found that 30-50% of Alzheimer's disease cases are potentially attributable to 7 modifiable risk factors--including physical inactivity, low education, smoking, depression, diabetes, mid-life hypertension and mid-life obesity--and that relatively small reductions in these risk factors at a societal level could potentially prevent millions of cases of Alzheimer's disease from ever occurring. These findings also received extensive international media coverage, including the New York Times, Wall Street Journal, and International Herald Tribune. Several recent studies have supported these projections by showing that age-adjusted dementia prevalence rates are declining in many countries in parallel with changes in societal-level risk factors such as improved education, reduced smoking and better control of vascular risk factors.

    My most recent research is focusing on performing randomized, controlled trials (RCTs) to evaluate the effectiveness of interventions for enhancing cognitive and physical function in late life. I participated in a pilot RCT of a computer-based cognitive training program in individuals with mild cognitive impairment (Barnes et al., Alz Disease Assoc Disord 2009). In addition, I designed and implemented a larger RCT comparing the effects of different physical (aerobic vs. stretching) and mental (intensive computer training vs. educational DVDs) activities on cognitive function in older adults who self-reported a recent decline in memory or thinking (Barnes et al., JAMA Intern Med 2013; Pa et al., JAGS 2015; Poelke et al, Int Psychogeriatr 2016; Kalapatapu J Addict Dis 2017). This trial, called the Mental Activity and eXercise (MAX) Trial, was funded jointly through funds from my K01 award and an Alzheimer?'s Association grant. In addition, I have recently led the development of a novel integrative exercise program for people with dementia call Preventing Loss of Independence through Exercise (PLIÉ) that incorporates training of procedural memory for basic daily movements with mindful body awareness and social connection through group movement. Our pilot study results suggested that PLIÉ is associated with meaningful improvements in cognitive function, physical function, quality of life and caregiver burden, with effect sizes that are two to three times larger than current dementia medications (Barnes et al., PLoS One 2014; Wu et al., Aging Ment Health 2014). I am PI of a VA Merit grant to study the efficacy of PLIÉ in a full-scale RCT and an Alzheimer's Association grant to test an adapted version for pairs of affected individuals and care partners (Paired PLIÉ). In addition, I received a VA Innovators award to begin to spread the program to other sites. I am deeply committed to performing research that is designed to help older adults maintain cognitive function, physical function and quality of life.

    Collapse Research 
    Collapse Research Activities and Funding
    Development and Validation of the EMR Risk of Alzheimer's and Dementia Assessment Rule (eRADAR)
    NIH/NIA R56AG056417Sep 15, 2017 - Aug 31, 2018
    Role: Principal Investigator
    Paired Integrative Exercise Program for People with Dementia and Caregivers
    Alzheimer's Association NPSASA-15-364656Jan 1, 2016 - Dec 31, 2018
    Role: PI
    Role Description: This project involves a randomized, controlled trial to test the efficacy of the Paired PLIÉ program for improving function and quality of life in people living with dementia and caregivers in the community.
    Preventing Loss of Independence through Exercise (PLIE) in Persons with Dementia
    VA I01RX001507Jan 1, 2015 - Dec 31, 2018
    Role: Principal Investigator
    Identification of Key Dementia Risk Factors for Older Veterans
    Department of Defense W81XWH-11-2-0189Oct 1, 2011 - Sep 30, 2014
    Role: PI
    Computer-Based Training in Older Adults with Memory Complaints
    Alzheimer's Association IIRG-06-27306Apr 1, 2007 - Mar 31, 2007
    Role: PI
    Physical Activity and Cognitive Decline in the Elderly
    NIH/NIA K01AG024069Sep 30, 2005 - Apr 30, 2010
    Role: Principal Investigator
    NIH/NIMH F31MH012665Jun 1, 2000
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News
    Collapse Clinical Trials
    Collapse Twitter
    Collapse Featured Videos
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Seal KH, Bertenthal D, Barnes DE, Byers AL, Gibson CJ, Yaffe K. Traumatic Brain Injury and Receipt of Prescription Opioid Therapy for Chronic Pain in Iraq and Afghanistan Veterans: Do Clinical Practice Guidelines Matter? J Pain. 2018 Mar 26. PMID: 29597083.
      View in: PubMed
    2. Lee SJ, Larson EB, Dublin S, Walker R, Marcum Z, Barnes D. A Cohort Study of Healthcare Utilization in Older Adults with Undiagnosed Dementia. J Gen Intern Med. 2018 Jan; 33(1):13-15. PMID: 28849435.
      View in: PubMed
    3. Goldstein LA, Mehling WE, Metzler TJ, Cohen BE, Barnes D, Choucroun GJ, Silver A, Talbot LS, Maguen S, Hlavin JA, Chesney MA, Neylan TC. Veterans Group Exercise: A randomized pilot trial of an Integrative Exercise program for veterans with posttraumatic stress. J Affect Disord. 2018 Feb; 227:345-352. PMID: 29145076.
      View in: PubMed
    4. Mehling WE, Chesney MA, Metzler TJ, Goldstein LA, Maguen S, Geronimo C, Agcaoili G, Barnes D, Hlavin JA, Neylan TC. A 12-week integrative exercise program improves self-reported mindfulness and interoceptive awareness in war veterans with posttraumatic stress symptoms. J Clin Psychol. 2018 Apr; 74(4):554-565. PMID: 29076530.
      View in: PubMed
    5. Middleton LE, Ventura MI, Santos-Modesitt W, Poelke G, Yaffe K, Barnes DE. The Mental Activity and eXercise (MAX) trial: Effects on physical function and quality of life among older adults with cognitive complaints. Contemp Clin Trials. 2018 Jan; 64:161-166. PMID: 29066293.
      View in: PubMed
    6. Walker E, McMahan R, Barnes D, Katen M, Lamas D, Sudore R. Advance Care Planning Documentation Practices and Accessibility in the Electronic Health Record: Implications for Patient Safety. J Pain Symptom Manage. 2018 Feb; 55(2):256-264. PMID: 28943360.
      View in: PubMed
    7. Anstey KJ, Peters R, Clare L, Lautenschlager NT, Dodge HH, Barnes DE, Shahar S, Brodaty H, Rees G. Joining forces to prevent dementia: The International Research Network On Dementia Prevention (IRNDP). Int Psychogeriatr. 2017 Nov; 29(11):1757-1760. PMID: 28899450.
      View in: PubMed
    8. Sudore RL, Boscardin J, Feuz MA, McMahan RD, Katen MT, Barnes D. Effect of the PREPARE Website vs an Easy-to-Read Advance Directive on Advance Care Planning Documentation and Engagement Among Veterans: A Randomized Clinical Trial. JAMA Intern Med. 2017 Aug 01; 177(8):1102-1109. PMID: 28520838.
      View in: PubMed
    9. Seal KH, Bertenthal D, Barnes DE, Byers AL, Strigo I, Yaffe K. Association of Traumatic Brain Injury With Chronic Pain in Iraq and Afghanistan Veterans: Effect of Comorbid Mental Health Conditions. Arch Phys Med Rehabil. 2017 08; 98(8):1636-1645. PMID: 28455190.
      View in: PubMed
    10. Sudore RL, Heyland DK, Barnes DE, Howard M, Fassbender K, Robinson CA, Boscardin J, You JJ. Measuring Advance Care Planning: Optimizing the Advance Care Planning Engagement Survey. J Pain Symptom Manage. 2017 Apr; 53(4):669-681.e8. PMID: 28042072.
      View in: PubMed
    11. Vossel KA, Ranasinghe KG, Beagle AJ, Mizuiri D, Honma SM, Dowling AF, Darwish SM, Van Berlo V, Barnes D, Mantle M, Karydas AM, Coppola G, Roberson ED, Miller BL, Garcia PA, Kirsch HE, Mucke L, Nagarajan SS. Incidence and impact of subclinical epileptiform activity in Alzheimer's disease. Ann Neurol. 2016 Dec; 80(6):858-870. PMID: 27696483.
      View in: PubMed
    12. Ventura MI, Barnes D, Ross JM, Lanni KE, Sigvardt KA, Disbrow EA. A pilot study to evaluate multi-dimensional effects of dance for people with Parkinson's disease. Contemp Clin Trials. 2016 11; 51:50-55. PMID: 27765693.
      View in: PubMed
    13. Kalapatapu RK, Ventura MI, Barnes DE. Lifetime alcohol use and cognitive performance in older adults. J Addict Dis. 2017 Jan-Mar; 36(1):38-47. PMID: 27719514.
      View in: PubMed
    14. Sudore RL, Barnes D, Le GM, Ramos R, Osua SJ, Richardson SA, Boscardin J, Schillinger D. Improving advance care planning for English-speaking and Spanish-speaking older adults: study protocol for the PREPARE randomised controlled trial. BMJ Open. 2016 07 11; 6(7):e011705. PMID: 27401363; PMCID: PMC4947727.
    15. Flatt JD, Williams BA, Barnes D, Goldenson J, Ahalt C, et al. Post-traumatic stress disorder symptoms and associated health and social vulnerabilities in older jail inmates. Aging Ment Health. 2017 Oct; 21(10):1106-1112. PMID: 27367335.
      View in: PubMed
    16. Barbour KE, Lui LY, McCulloch CE, Ensrud KE, Cawthon PM, Yaffe K, Barnes D, Fredman L, Newman AB, Cummings SR, Cauley JA, et al. Trajectories of Lower Extremity Physical Performance: Effects on Fractures and Mortality in Older Women. J Gerontol A Biol Sci Med Sci. 2016 12; 71(12):1609-1615. PMID: 27084313.
      View in: PubMed
    17. Ritchie C, Andersen R, Eng J, Garrigues SK, Intinarelli G, Kao H, Kawahara S, Patel K, Sapiro L, Thibault A, Tunick E, Barnes DE. Implementation of an Interdisciplinary, Team-Based Complex Care Support Health Care Model at an Academic Medical Center: Impact on Health Care Utilization and Quality of Life. PLoS One. 2016; 11(2):e0148096. PMID: 26871704; PMCID: PMC4752211.
    18. Sudore R, Le GM, McMahan R, Feuz M, Katen M, Barnes DE. Erratum to: 'The advance care planning PREPARE study among older Veterans with serious and chronic illness: study protocol for a randomized controlled trial'. Trials. 2016 Jan 20; 17:42. PMID: 26791078; PMCID: PMC4721198.
    19. Sudore R, Le GM, McMahon R, Feuz M, Katen M, Barnes DE. The advance care planning PREPARE study among older Veterans with serious and chronic illness: study protocol for a randomized controlled trial. Trials. 2015 Dec 12; 16:570. PMID: 26654250.
      View in: PubMed
    20. Ventura MI, Edwards JD, Barnes DE. More than just a movement disorder: Why cognitive training is needed in Parkinson disease. Neurology. 2015 Nov 24; 85(21):1828-9. PMID: 26519546.
      View in: PubMed
    21. MacDonald JP, Barnes DE, Middleton LE. Implications of Risk Factors for Alzheimer's Disease in Canada's Indigenous Population. Can Geriatr J. 2015 Sep; 18(3):152-8. PMID: 26495049; PMCID: PMC4597815.
    22. Poelke G, Ventura MI, Byers AL, Yaffe K, Sudore R, Barnes DE. Leisure activities and depressive symptoms in older adults with cognitive complaints. Int Psychogeriatr. 2016 Jan; 28(1):63-9. PMID: 26299193.
      View in: PubMed
    23. Hixson JD, Barnes D, Parko K, Durgin T, Van Bebber S, Graham A, Wicks P. Patients optimizing epilepsy management via an online community: the POEM Study. Neurology. 2015 Jul 14; 85(2):129-36. PMID: 26085605; PMCID: PMC4515038.
    24. Barnes DE, Mehling W, Wu E, Beristianos M, Yaffe K, Skultety K, Chesney MA. Preventing loss of independence through exercise (PLIÉ): a pilot clinical trial in older adults with dementia. PLoS One. 2015; 10(2):e0113367. PMID: 25671576; PMCID: PMC4324943.
    25. Lee SJ, Ritchie CS, Yaffe K, Stijacic Cenzer I, Barnes DE. A clinical index to predict progression from mild cognitive impairment to dementia due to Alzheimer's disease. PLoS One. 2014; 9(12):e113535. PMID: 25486250; PMCID: PMC4259326.
    26. Pa J, Goodson W, Bloch A, King AC, Yaffe K, Barnes DE. Effect of exercise and cognitive activity on self-reported sleep quality in community-dwelling older adults with cognitive complaints: a randomized controlled trial. J Am Geriatr Soc. 2014 Dec; 62(12):2319-26. PMID: 25516028; PMCID: PMC4356237.
    27. Gardner RC, Burke JF, Nettiksimmons J, Kaup A, Barnes DE, Yaffe K. Dementia risk after traumatic brain injury vs nonbrain trauma: the role of age and severity. JAMA Neurol. 2014 Dec; 71(12):1490-7. PMID: 25347255; PMCID: PMC4318558.
    28. Norton S, Matthews FE, Barnes DE, Yaffe K, Brayne C. Potential for primary prevention of Alzheimer's disease: an analysis of population-based data. Lancet Neurol. 2014 Aug; 13(8):788-94. PMID: 25030513.
      View in: PubMed
    29. Wu E, Barnes DE, Ackerman SL, Lee J, Chesney M, Mehling WE. Preventing Loss of Independence through Exercise (PLIÉ): qualitative analysis of a clinical trial in older adults with dementia. Aging Ment Health. 2015; 19(4):353-62. PMID: 25022459.
      View in: PubMed
    30. Barnes DE, Kaup A, Kirby KA, Byers AL, Diaz-Arrastia R, Yaffe K. Traumatic brain injury and risk of dementia in older veterans. Neurology. 2014 Jul 22; 83(4):312-9. PMID: 24966406; PMCID: PMC4115602.
    31. Meziab O, Kirby KA, Williams B, Yaffe K, Byers AL, Barnes DE. Prisoner of war status, posttraumatic stress disorder, and dementia in older veterans. Alzheimers Dement. 2014 Jun; 10(3 Suppl):S236-41. PMID: 24924674.
      View in: PubMed
    32. Yaffe K, Hoang TD, Byers AL, Barnes DE, Friedl KE. Lifestyle and health-related risk factors and risk of cognitive aging among older veterans. Alzheimers Dement. 2014 Jun; 10(3 Suppl):S111-21. PMID: 24924664.
      View in: PubMed
    33. Hoang TD, Byers AL, Barnes DE, Yaffe K. Alcohol consumption patterns and cognitive impairment in older women. Am J Geriatr Psychiatry. 2014 Dec; 22(12):1663-7. PMID: 24862680; PMCID: PMC4353638.
    34. Goveas JS, Espeland MA, Hogan PE, Tindle HA, Shih RA, Kotchen JM, Robinson JG, Barnes DE, Resnick SM. Depressive Symptoms and Longitudinal Changes in Cognition: Women's Health Initiative Study of Cognitive Aging. J Geriatr Psychiatry Neurol. 2014 Jun; 27(2):94-102. PMID: 24584465; PMCID: PMC4433445.
    35. Barnes DE, Cenzer IS, Yaffe K, Ritchie CS, Lee SJ. A point-based tool to predict conversion from mild cognitive impairment to probable Alzheimer's disease. Alzheimers Dement. 2014 Nov; 10(6):646-55. PMID: 24495339.
      View in: PubMed
    36. Barnes DE, Beiser AS, Lee A, Langa KM, Koyama A, Preis SR, Neuhaus J, McCammon RJ, Yaffe K, Seshadri S, Haan MN, Weir DR. Development and validation of a brief dementia screening indicator for primary care. Alzheimers Dement. 2014 Nov; 10(6):656-665.e1. PMID: 24491321.
      View in: PubMed
    37. Mackin RS, Nelson JC, Delucchi K, Raue P, Byers A, Barnes D, Satre DD, Yaffe K, Alexopoulos GS, Arean PA. Cognitive outcomes after psychotherapeutic interventions for major depression in older adults with executive dysfunction. Am J Geriatr Psychiatry. 2014 Dec; 22(12):1496-503. PMID: 24378255; PMCID: PMC4108572.
    38. Cohen BE, Neylan TC, Yaffe K, Samuelson KW, Li Y, Barnes DE. Posttraumatic stress disorder and cognitive function: findings from the mind your heart study. J Clin Psychiatry. 2013 Nov; 74(11):1063-70. PMID: 24330891.
      View in: PubMed
    39. Exalto LG, Quesenberry CP, Barnes D, Kivipelto M, Biessels GJ, Whitmer RA. Midlife risk score for the prediction of dementia four decades later. Alzheimers Dement. 2014 Sep; 10(5):562-70. PMID: 24035147.
      View in: PubMed
    40. Sudore RL, Stewart AL, Knight SJ, McMahan RD, Feuz M, Miao Y, Barnes DE. Development and validation of a questionnaire to detect behavior change in multiple advance care planning behaviors. PLoS One. 2013; 8(9):e72465. PMID: 24039772; PMCID: PMC3764010.
    41. Sudore RL, Knight SJ, McMahan RD, Feuz M, Farrell D, Miao Y, Barnes DE. A novel website to prepare diverse older adults for decision making and advance care planning: a pilot study. J Pain Symptom Manage. 2014 Apr; 47(4):674-86. PMID: 23972574; PMCID: PMC4111443.
    42. Wang S, Luo X, Barnes D, Sano M, Yaffe K. Physical activity and risk of cognitive impairment among oldest-old women. Am J Geriatr Psychiatry. 2014 Nov; 22(11):1149-57. PMID: 23831179; PMCID: PMC3864545.
    43. Barnes DE, Santos-Modesitt W, Poelke G, Kramer AF, Castro C, Middleton LE, Yaffe K. The Mental Activity and eXercise (MAX) trial: a randomized controlled trial to enhance cognitive function in older adults. JAMA Intern Med. 2013 May 13; 173(9):797-804. PMID: 23545598.
      View in: PubMed
    44. Barnes DE, Boscardin WJ, Landefeld CS. Recovery, dependence or death after discharge. J Gen Intern Med. 2013 Mar; 28(3):343. PMID: 23435831; PMCID: PMC3579963.
    45. Barnes DE, Mehta KM, Boscardin WJ, Fortinsky RH, Palmer RM, Kirby KA, Landefeld CS. Prediction of recovery, dependence or death in elders who become disabled during hospitalization. J Gen Intern Med. 2013 Feb; 28(2):261-8. PMID: 23054919; PMCID: PMC3614138.
    46. Byers AL, Covinsky KE, Barnes DE, Yaffe K. Dysthymia and depression increase risk of dementia and mortality among older veterans. Am J Geriatr Psychiatry. 2012 Aug; 20(8):664-72. PMID: 21597358; PMCID: PMC3229643.
    47. Barnes DE, Palmer RM, Kresevic DM, Fortinsky RH, Kowal J, Chren MM, Landefeld CS. Acute care for elders units produced shorter hospital stays at lower cost while maintaining patients' functional status. Health Aff (Millwood). 2012 Jun; 31(6):1227-36. PMID: 22665834; PMCID: PMC3870859.
    48. Barnes DE, Yaffe K, Byers AL, McCormick M, Schaefer C, Whitmer RA. Midlife vs late-life depressive symptoms and risk of dementia: differential effects for Alzheimer disease and vascular dementia. Arch Gen Psychiatry. 2012 May; 69(5):493-8. PMID: 22566581; PMCID: PMC3704214.
    49. Barnes DE, Lee SJ. Predicting Alzheimer's risk: why and how? Alzheimers Res Ther. 2011 Nov 25; 3(6):33. PMID: 22126363; PMCID: PMC3308022.
    50. Barnes DE, Yaffe K. The projected effect of risk factor reduction on Alzheimer's disease prevalence. Lancet Neurol. 2011 Sep; 10(9):819-28. PMID: 21775213; PMCID: PMC3647614.
    51. Middleton LE, Manini TM, Simonsick EM, Harris TB, Barnes DE, Tylavsky F, Brach JS, Everhart JE, Yaffe K. Activity energy expenditure and incident cognitive impairment in older adults. Arch Intern Med. 2011 Jul 25; 171(14):1251-7. PMID: 21771893; PMCID: PMC3923462.
    52. Barnes DE, Yaffe K. Accuracy of summary risk score for prediction of Alzheimer disease: better than demographics alone? Arch Neurol. 2011 Feb; 68(2):268; author reply 268-70. PMID: 21321000.
      View in: PubMed
    53. Barnes DE. The mediterranean diet: good for the heart = good for the brain? Ann Neurol. 2011 Feb; 69(2):226-8. PMID: 21387364.
      View in: PubMed
    54. Middleton LE, Barnes DE, Lui LY, Yaffe K. Physical activity over the life course and its association with cognitive performance and impairment in old age. J Am Geriatr Soc. 2010 Jul; 58(7):1322-6. PMID: 20609030; PMCID: PMC3662219.
    55. Yaffe K, Vittinghoff E, Lindquist K, Barnes D, Covinsky KE, Neylan T, Kluse M, Marmar C. Posttraumatic stress disorder and risk of dementia among US veterans. Arch Gen Psychiatry. 2010 Jun; 67(6):608-13. PMID: 20530010; PMCID: PMC2933793.
    56. Yaffe K, Lindquist K, Vittinghoff E, Barnes D, Simonsick EM, Newman A, Satterfield S, Rosano C, Rubin SM, Ayonayon HN, Harris T. The effect of maintaining cognition on risk of disability and death. J Am Geriatr Soc. 2010 May; 58(5):889-94. PMID: 20406308; PMCID: PMC2924918.
    57. Barnes DE, Covinsky KE, Whitmer RA, Kuller LH, Lopez OL, Yaffe K. Commentary on "Developing a national strategy to prevent dementia: Leon Thal Symposium 2009." Dementia risk indices: A framework for identifying individuals with a high dementia risk. Alzheimers Dement. 2010 Mar; 6(2):138-41. PMID: 20298975; PMCID: PMC2909695.
    58. Khachaturian ZS, Barnes D, Einstein R, Johnson S, Lee V, Roses A, Sager MA, Shankle WR, Snyder PJ, Petersen RC, Schellenberg G, Trojanowski J, Aisen P, Albert MS, Breitner JC, Buckholtz N, Carrillo M, Ferris S, Greenberg BD, Grundman M, Khachaturian AS, Kuller LH, Lopez OL, Maruff P, Mohs RC, Morrison-Bogorad M, Phelps C, Reiman E, Sabbagh M, Sano M, Schneider LS, Siemers E, Tariot P, Touchon J, Vellas B, Bain LJ. Developing a national strategy to prevent dementia: Leon Thal Symposium 2009. Alzheimers Dement. 2010 Mar; 6(2):89-97. PMID: 20298968; PMCID: PMC4298995.
    59. Barnes DE, Haight TJ, Mehta KM, Carlson MC, Kuller LH, Tager IB. Secondhand smoke, vascular disease, and dementia incidence: findings from the cardiovascular health cognition study. Am J Epidemiol. 2010 Feb 01; 171(3):292-302. PMID: 20051462; PMCID: PMC2878108.
    60. Barnes DE, Yaffe K. Predicting dementia: role of dementia risk indices. Future Neurol. 2009 Sep 01; 4(5):555-560. PMID: 20161571.
      View in: PubMed
    61. Becker JT, Chang YF, Lopez OL, Dew MA, Sweet RA, Barnes D, Yaffe K, Young J, Kuller L, Reynolds CF. Depressed mood is not a risk factor for incident dementia in a community-based cohort. Am J Geriatr Psychiatry. 2009 Aug; 17(8):653-63. PMID: 19634208; PMCID: PMC2714703.
    62. Edwards ER, Spira AP, Barnes DE, Yaffe K. Neuropsychiatric symptoms in mild cognitive impairment: differences by subtype and progression to dementia. Int J Geriatr Psychiatry. 2009 Jul; 24(7):716-22. PMID: 19140134; PMCID: PMC2735341.
    63. Barnes DE, Yaffe K, Belfor N, Jagust WJ, DeCarli C, Reed BR, Kramer JH. Computer-based cognitive training for mild cognitive impairment: results from a pilot randomized, controlled trial. Alzheimer Dis Assoc Disord. 2009 Jul-Sep; 23(3):205-10. PMID: 19812460; PMCID: PMC2760033.
    64. Barnes DE, Covinsky KE, Whitmer RA, Kuller LH, Lopez OL, Yaffe K. Predicting risk of dementia in older adults: The late-life dementia risk index. Neurology. 2009 Jul 21; 73(3):173-9. PMID: 19439724; PMCID: PMC2715571.
    65. Cauley JA, Lui LY, Barnes D, Ensrud KE, Zmuda JM, Hillier TA, Hochberg MC, Schwartz AV, Yaffe K, Cummings SR, Newman AB. Successful skeletal aging: a marker of low fracture risk and longevity. The Study of Osteoporotic Fractures (SOF). J Bone Miner Res. 2009 Jan; 24(1):134-43. PMID: 18715137; PMCID: PMC2605163.
    66. Barnes DE, Blackwell T, Stone KL, Goldman SE, Hillier T, Yaffe K. Cognition in older women: the importance of daytime movement. J Am Geriatr Soc. 2008 Sep; 56(9):1658-64. PMID: 18662201; PMCID: PMC2680379.
    67. Mehta KM, Yaffe K, Pérez-Stable EJ, Stewart A, Barnes D, Kurland BF, Miller BL. Race/ethnic differences in AD survival in US Alzheimer's Disease Centers. Neurology. 2008 Apr 01; 70(14):1163-70. PMID: 18003939; PMCID: PMC2830859.
    68. Sudore RL, Landefeld CS, Barnes DE, Lindquist K, Williams BA, Brody R, Schillinger D. An advance directive redesigned to meet the literacy level of most adults: a randomized trial. Patient Educ Couns. 2007 Dec; 69(1-3):165-95. PMID: 17942272; PMCID: PMC2257986.
    69. Yaffe K, Blackwell T, Barnes DE, Ancoli-Israel S, Stone KL. Preclinical cognitive decline and subsequent sleep disturbance in older women. Neurology. 2007 Jul 17; 69(3):237-42. PMID: 17636060.
      View in: PubMed
    70. Barnes DE, Cauley JA, Lui LY, Fink HA, McCulloch C, Stone KL, Yaffe K. Women who maintain optimal cognitive function into old age. J Am Geriatr Soc. 2007 Feb; 55(2):259-64. PMID: 17302664.
      View in: PubMed
    71. Barnes DE, Whitmer RA, Yaffe K. Physical activity and dementia: The need for prevention trials. Exerc Sport Sci Rev. 2007 Jan; 35(1):24-9. PMID: 17211190.
      View in: PubMed
    72. Yaffe K, Barnes D, Lindquist K, Cauley J, Simonsick EM, Penninx B, Satterfield S, Harris T, Cummings SR. Endogenous sex hormone levels and risk of cognitive decline in an older biracial cohort. Neurobiol Aging. 2007 Feb; 28(2):171-8. PMID: 17097195.
      View in: PubMed
    73. Sudore RL, Landefeld CS, Williams BA, Barnes DE, Lindquist K, Schillinger D. Use of a modified informed consent process among vulnerable patients: a descriptive study. J Gen Intern Med. 2006 Aug; 21(8):867-73. PMID: 16881949; PMCID: PMC1831581.
    74. Sink KM, Covinsky KE, Barnes DE, Newcomer RJ, Yaffe K. Caregiver characteristics are associated with neuropsychiatric symptoms of dementia. J Am Geriatr Soc. 2006 May; 54(5):796-803. PMID: 16696746.
      View in: PubMed
    75. Barnes DE, Alexopoulos GS, Lopez OL, Williamson JD, Yaffe K. Depressive symptoms, vascular disease, and mild cognitive impairment: findings from the Cardiovascular Health Study. Arch Gen Psychiatry. 2006 Mar; 63(3):273-9. PMID: 16520432.
      View in: PubMed
    76. Barnes DE, Yaffe K. Vitamin E and donepezil for the treatment of mild cognitive impairment. N Engl J Med. 2005 Sep 01; 353(9):951-2; author reply 951-2. PMID: 16135844.
      View in: PubMed
    77. Barnes DE, Tager IB, Satariano WA, Yaffe K. The relationship between literacy and cognition in well-educated elders. J Gerontol A Biol Sci Med Sci. 2004 Apr; 59(4):390-5. PMID: 15071084.
      View in: PubMed
    78. Barnes DE, Yaffe K, Satariano WA, Tager IB. A longitudinal study of cardiorespiratory fitness and cognitive function in healthy older adults. J Am Geriatr Soc. 2003 Apr; 51(4):459-65. PMID: 12657064.
      View in: PubMed
    79. Yaffe K, Barnes D, Nevitt M, Lui LY, Covinsky K. A prospective study of physical activity and cognitive decline in elderly women: women who walk. Arch Intern Med. 2001 Jul 23; 161(14):1703-8. PMID: 11485502.
      View in: PubMed
    80. Barnes DE, Bero LA. Why review articles on the health effects of passive smoking reach different conclusions. JAMA. 1998 May 20; 279(19):1566-70. PMID: 9605902.
      View in: PubMed
    81. Barnes DE, Bero LA. Scientific quality of original research articles on environmental tobacco smoke. Tob Control. 1997; 6(1):19-26. PMID: 9176982; PMCID: PMC1759539.
    82. Barnes DE, Bero LA. Industry-funded research and conflict of interest: an analysis of research sponsored by the tobacco industry through the Center for Indoor Air Research. J Health Polit Policy Law. 1996; 21(3):515-42. PMID: 8784687.
      View in: PubMed
    83. Hanauer P, Slade J, Barnes DE, Bero L, Glantz SA. Lawyer control of internal scientific research to protect against products liability lawsuits. The Brown and Williamson documents. JAMA. 1995 Jul 19; 274(3):234-40. PMID: 7609232.
      View in: PubMed
    84. Slade J, Bero LA, Hanauer P, Barnes DE, Glantz SA. Nicotine and addiction. The Brown and Williamson documents. JAMA. 1995 Jul 19; 274(3):225-33. PMID: 7609231.
      View in: PubMed
    85. Barnes DE, Hanauer P, Slade J, Bero LA, Glantz SA. Environmental tobacco smoke. The Brown and Williamson documents. JAMA. 1995 Jul 19; 274(3):248-53. PMID: 7609234.
      View in: PubMed
    86. Bero L, Barnes DE, Hanauer P, Slade J, Glantz SA. Lawyer control of the tobacco industry's external research program. The Brown and Williamson documents. JAMA. 1995 Jul 19; 274(3):241-7. PMID: 7609233.
      View in: PubMed
    87. Glantz SA, Barnes DE, Bero L, Hanauer P, Slade J. Looking through a keyhole at the tobacco industry. The Brown and Williamson documents. JAMA. 1995 Jul 19; 274(3):219-24. PMID: 7609230.
      View in: PubMed
    88. Bellows EP, Barnes DE, Csernansky JG. Estimation of haloperidol concentrations in rat striatum after chronic treatment. Brain Res Bull. 1991 May; 26(5):715-9. PMID: 1933392.
      View in: PubMed
    89. Barnes DE, Robinson B, Csernansky JG, Bellows EP. Sensitization versus tolerance to haloperidol-induced catalepsy: multiple determinants. Pharmacol Biochem Behav. 1990 Aug; 36(4):883-7. PMID: 2217518.
      View in: PubMed
    90. Csernansky JG, Bellows EP, Barnes DE, Lombrozo L. Sensitization versus tolerance to the dopamine turnover-elevating effects of haloperidol: the effect of regular/intermittent dosing. Psychopharmacology (Berl). 1990; 101(4):519-24. PMID: 2388975.
      View in: PubMed
    91. Csernansky JG, Barnes DE, Bellows EP, Lombrozo L. Interrelationships between plasma homovanillic acid and indices of dopamine turnover in multiple brain areas during haloperidol and saline administration. Life Sci. 1990; 46(10):707-13. PMID: 2314192.
      View in: PubMed
    Deborah's Networks
    Derived automatically from this person's publications.
    People in Profiles who have published with this person.
    Related Authors
    People who share related concepts with this person.
    Back to TOP