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    Deborah Barnes, PhD

    TitleAssociate Professor
    SchoolUCSF School of Medicine
    DepartmentPsychiatry
    Address4150 Clement Street
    San Francisco CA 94121
    Phone415-221-4810x4221

       Biography 
       Awards and Honors
      Clinical and Translational Sciences Institute, UCSF2013Consultant of the Year awardee
      Medical Student Training in Aging Research program2011Mentor of the Year awardee
      Bay Area Clinical Research Symposium2010Mentor of the Year nominee
      National Institute on Aging2005K01 Career Development Award (AG-024069)
      Alzheimer's Association of Northern California and Northern Nevada2003Student Award for Excellence in Alzheimer's Research
      University of California, Berkeley2001Paola Timiras Award for Research on Aging
      National Institute of Mental Health2000National Research Service Award for Individual Predoctoral Fellows (F31 MH12665)

       Overview 
       Overview
      Dementia prevalence is expected to quadruple worldwide over the next 40 years at tremendous monetary and emotional cost. Dr. Barnes' research is designed to minimize the impact of the impending dementia epidemic using a three-pronged approach for developing and evaluating strategies to maintain cognitive function and prevent or delay dementia onset in late life: 1) identification of risk factors for cognitive impairment and dementia in older adults, 2) evaluation of prevention strategies for helping older adults to maintain cognitive function with age, and 3) development of dementia risk prediction models that can be used to estimate the impact of risk factor reduction and to target prevention strategies toward those who are at greatest risk.

      Dr. Barnes' has published numerous observational studies related to identification of factors associated with increased or decreased risk of cognitive decline and dementia. She has been particularly interested in the potential protective effects of physical and mental activity as well as the complex relationship between depression and cognitive impairment. Taken together, this work suggests that there are a variety of potential strategies for lowering risk of cognitive impairment and dementia in late life.

      Dr. Barnes also has lead several randomized, controlled trials (RCTs) to evaluate the effectiveness of interventions for enhancing cognitive function in late life. One study examined the effects of a computer-based cognitive training program in individuals with mild cognitive impairment. Another study used a factorial design to examine the effects of combined physical (aerobic vs. stretching) and mental (intensive computer training vs. educational DVDs) activities on cognitive function in older adults who self-report a recent decline in memory or thinking. This trial, called the Mental Activity and eXercise (MAX) Trial, was funded jointly through a K01 award and an Alzheimer’s Association grant. Another recent project involves developing and pilot-testing an exercise program called Preventing Loss of Independence through Exercis (PLIÉ), which integrates elements of yoga, Tai Chi, Feldenkrais and occupational/physical therapy to help older adults with dementia maintain functional status.

      Finally, Dr. Barnes has been at the forefront of efforts to develop dementia risk prediction models and to project the potential impact of changes in risk factor profiles. One study found that a combination of demographic, cognitive, behavioral, functional, medical, genetic, cerebral MRI findings and carotid artery ultrasound measures could be used to predict an individual’s six-year risk of dementia with high accuracy. This publication generated substantial interest from clinicians and researchers world-wide as well as the lay press, including interviews with CBS Evening News, ABC News Online, US News & World Report, and Time. A follow-up publication found that an abbreviated index that included only items that could be administered quickly without special equipment was almost as accurate as the original index. This line of research has led to invited editorials about dementia risk prediction and involvement with an NIA workgroup that is developing national guidelines for dementia risk assessment.

      This work was recently expanded in a study that projected the potential impact of risk factor reduction on future dementia prevalence, which found that up to half of Alzheimer's disease cases were potentially attributable to 7 modifiable risk factors--including physical inactivity, low education, smoking, depression, diabetes, mid-life hypertension and mid-life obesity--and that relatively small reductions in these risk factors at a societal level could potentially prevent millions of cases of Alzheimer's disease from ever occurring. These findings also received extensive international media coverage, including the New York Times, Wall Street Journal, and International Herald Tribune.

       Interests
      Implementation Science, Older adults, Persons with physical disability, Persons with mental illness, cognitive impairment/dementia counted as 'mental illness', Community-based organization, intervention research study, older adults, cognitive function, dementia, physical activity, mental activity, Interdisciplinary research collaboration, Implementation & dissemination science listservs

       ORNG Applications 
       Featured Publications
       In The News
       More Info

       Bibliographic 
       Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Norton S, Matthews FE, Barnes DE, Yaffe K, Brayne C. Potential for primary prevention of Alzheimer's disease: an analysis of population-based data. Lancet Neurol. 2014 Aug; 13(8):788-94.
        View in: PubMed
      2. Wu E, Barnes DE, Ackerman SL, Lee J, Chesney M, Mehling WE. Preventing Loss of Independence through Exercise (PLIÉ): qualitative analysis of a clinical trial in older adults with dementia. Aging Ment Health. 2014 Jul 14; 1-10.
        View in: PubMed
      3. Barnes DE, Kaup A, Kirby KA, Byers AL, Diaz-Arrastia R, Yaffe K. Traumatic brain injury and risk of dementia in older veterans. Neurology. 2014 Jul 22; 83(4):312-9.
        View in: PubMed
      4. Yaffe K, Hoang TD, Byers AL, Barnes DE, Friedl KE. Lifestyle and health-related risk factors and risk of cognitive aging among older veterans. Alzheimers Dement. 2014 Jun; 10(3 Suppl):S111-21.
        View in: PubMed
      5. Meziab O, Kirby KA, Williams B, Yaffe K, Byers AL, Barnes DE. Prisoner of war status, posttraumatic stress disorder, and dementia in older veterans. Alzheimers Dement. 2014 Jun; 10(3 Suppl):S236-41.
        View in: PubMed
      6. Hoang TD, Byers AL, Barnes DE, Yaffe K. Alcohol Consumption Patterns and Cognitive Impairment in Older Women. Am J Geriatr Psychiatry. 2014 Apr 26.
        View in: PubMed
      7. Goveas JS, Espeland MA, Hogan PE, Tindle HA, Shih RA, Kotchen JM, Robinson JG, Barnes DE, Resnick SM. Depressive Symptoms and Longitudinal Changes in Cognition: Women's Health Initiative Study of Cognitive Aging. J Geriatr Psychiatry Neurol. 2014 Feb 28; 27(2):94-102.
        View in: PubMed
      8. Barnes DE, Cenzer IS, Yaffe K, Ritchie CS, Lee SJ. A point-based tool to predict conversion from mild cognitive impairment to probable Alzheimer's disease. Alzheimers Dement. 2014 Feb 1.
        View in: PubMed
      9. Barnes DE, Beiser AS, Lee A, Langa KM, Koyama A, Preis SR, Neuhaus J, McCammon RJ, Yaffe K, Seshadri S, Haan MN, Weir DR. Development and validation of a brief dementia screening indicator for primary care. Alzheimers Dement. 2014 Feb 1.
        View in: PubMed
      10. Mackin RS, Nelson JC, Delucchi K, Raue P, Byers A, Barnes D, Satre DD, Yaffe K, Alexopoulos GS, Arean PA. Cognitive Outcomes after Psychotherapeutic Interventions for Major Depression in Older Adults with Executive Dysfunction. Am J Geriatr Psychiatry. 2013 Nov 16.
        View in: PubMed
      11. Cohen BE, Neylan TC, Yaffe K, Samuelson KW, Li Y, Barnes DE. Posttraumatic stress disorder and cognitive function: findings from the mind your heart study. J Clin Psychiatry. 2013 Nov; 74(11):1063-70.
        View in: PubMed
      12. Exalto LG, Quesenberry CP, Barnes D, Kivipelto M, Biessels GJ, Whitmer RA. Midlife risk score for the prediction of dementia four decades later. Alzheimers Dement. 2014 Sep; 10(5):562-70.
        View in: PubMed
      13. Sudore RL, Stewart AL, Knight SJ, McMahan RD, Feuz M, Miao Y, Barnes DE. Development and validation of a questionnaire to detect behavior change in multiple advance care planning behaviors. PLoS One. 2013; 8(9):e72465.
        View in: PubMed
      14. Sudore RL, Knight SJ, McMahan RD, Feuz M, Farrell D, Miao Y, Barnes DE. A novel website to prepare diverse older adults for decision making and advance care planning: a pilot study. J Pain Symptom Manage. 2014 Apr; 47(4):674-86.
        View in: PubMed
      15. Wang S, Luo X, Barnes D, Sano M, Yaffe K. Physical activity and risk of cognitive impairment among oldest-old women. Am J Geriatr Psychiatry. 2014 Nov; 22(11):1149-57.
        View in: PubMed
      16. Barnes DE, Santos-Modesitt W, Poelke G, Kramer AF, Castro C, Middleton LE, Yaffe K. The Mental Activity and eXercise (MAX) trial: a randomized controlled trial to enhance cognitive function in older adults. JAMA Intern Med. 2013 May 13; 173(9):797-804.
        View in: PubMed
      17. Barnes DE, Boscardin WJ, Landefeld CS. Recovery, dependence or death after discharge. J Gen Intern Med. 2013 Mar; 28(3):343.
        View in: PubMed
      18. Barnes DE, Mehta KM, Boscardin WJ, Fortinsky RH, Palmer RM, Kirby KA, Landefeld CS. Prediction of recovery, dependence or death in elders who become disabled during hospitalization. J Gen Intern Med. 2013 Feb; 28(2):261-8.
        View in: PubMed
      19. Byers AL, Covinsky KE, Barnes DE, Yaffe K. Dysthymia and depression increase risk of dementia and mortality among older veterans. Am J Geriatr Psychiatry. 2012 Aug; 20(8):664-72.
        View in: PubMed
      20. Barnes DE, Palmer RM, Kresevic DM, Fortinsky RH, Kowal J, Chren MM, Landefeld CS. Acute care for elders units produced shorter hospital stays at lower cost while maintaining patients' functional status. Health Aff (Millwood). 2012 Jun; 31(6):1227-36.
        View in: PubMed
      21. Barnes DE, Yaffe K, Byers AL, McCormick M, Schaefer C, Whitmer RA. Midlife vs late-life depressive symptoms and risk of dementia: differential effects for Alzheimer disease and vascular dementia. Arch Gen Psychiatry. 2012 May; 69(5):493-8.
        View in: PubMed
      22. Barnes DE, Lee SJ. Predicting Alzheimer's risk: why and how? Alzheimers Res Ther. 2011; 3(6):33.
        View in: PubMed
      23. Barnes DE, Yaffe K. The projected effect of risk factor reduction on Alzheimer's disease prevalence. Lancet Neurol. 2011 Sep; 10(9):819-28.
        View in: PubMed
      24. Middleton LE, Manini TM, Simonsick EM, Harris TB, Barnes DE, Tylavsky F, Brach JS, Everhart JE, Yaffe K. Activity energy expenditure and incident cognitive impairment in older adults. Arch Intern Med. 2011 Jul 25; 171(14):1251-7.
        View in: PubMed
      25. Barnes DE, Yaffe K. Accuracy of summary risk score for prediction of Alzheimer disease: better than demographics alone? Arch Neurol. 2011 Feb; 68(2):268; author reply 268-70.
        View in: PubMed
      26. Barnes DE. The mediterranean diet: good for the heart = good for the brain? Ann Neurol. 2011 Feb; 69(2):226-8.
        View in: PubMed
      27. Middleton LE, Barnes DE, Lui LY, Yaffe K. Physical activity over the life course and its association with cognitive performance and impairment in old age. J Am Geriatr Soc. 2010 Jul; 58(7):1322-6.
        View in: PubMed
      28. Yaffe K, Vittinghoff E, Lindquist K, Barnes D, Covinsky KE, Neylan T, Kluse M, Marmar C. Posttraumatic stress disorder and risk of dementia among US veterans. Arch Gen Psychiatry. 2010 Jun; 67(6):608-13.
        View in: PubMed
      29. Yaffe K, Lindquist K, Vittinghoff E, Barnes D, Simonsick EM, Newman A, Satterfield S, Rosano C, Rubin SM, Ayonayon HN, Harris T. The effect of maintaining cognition on risk of disability and death. J Am Geriatr Soc. 2010 May; 58(5):889-94.
        View in: PubMed
      30. Barnes DE, Covinsky KE, Whitmer RA, Kuller LH, Lopez OL, Yaffe K. Commentary on "Developing a national strategy to prevent dementia: Leon Thal Symposium 2009." Dementia risk indices: A framework for identifying individuals with a high dementia risk. Alzheimers Dement. 2010 Mar; 6(2):138-41.
        View in: PubMed
      31. Khachaturian ZS, Barnes D, Einstein R, Johnson S, Lee V, Roses A, Sager MA, Shankle WR, Snyder PJ, Petersen RC, Schellenberg G, Trojanowski J, Aisen P, Albert MS, Breitner JC, Buckholtz N, Carrillo M, Ferris S, Greenberg BD, Grundman M, Khachaturian AS, Kuller LH, Lopez OL, Maruff P, Mohs RC, Morrison-Bogorad M, Phelps C, Reiman E, Sabbagh M, Sano M, Schneider LS, Siemers E, Tariot P, Touchon J, Vellas B, Bain LJ. Developing a national strategy to prevent dementia: Leon Thal Symposium 2009. Alzheimers Dement. 2010 Mar; 6(2):89-97.
        View in: PubMed
      32. Barnes DE, Haight TJ, Mehta KM, Carlson MC, Kuller LH, Tager IB. Secondhand smoke, vascular disease, and dementia incidence: findings from the cardiovascular health cognition study. Am J Epidemiol. 2010 Feb 1; 171(3):292-302.
        View in: PubMed
      33. Barnes DE, Yaffe K. Predicting dementia: role of dementia risk indices. Future Neurol. 2009 Sep 1; 4(5):555-560.
        View in: PubMed
      34. Becker JT, Chang YF, Lopez OL, Dew MA, Sweet RA, Barnes D, Yaffe K, Young J, Kuller L, Reynolds CF. Depressed mood is not a risk factor for incident dementia in a community-based cohort. Am J Geriatr Psychiatry. 2009 Aug; 17(8):653-63.
        View in: PubMed
      35. Barnes DE, Yaffe K, Belfor N, Jagust WJ, DeCarli C, Reed BR, Kramer JH. Computer-based cognitive training for mild cognitive impairment: results from a pilot randomized, controlled trial. Alzheimer Dis Assoc Disord. 2009 Jul-Sep; 23(3):205-10.
        View in: PubMed
      36. Edwards ER, Spira AP, Barnes DE, Yaffe K. Neuropsychiatric symptoms in mild cognitive impairment: differences by subtype and progression to dementia. Int J Geriatr Psychiatry. 2009 Jul; 24(7):716-22.
        View in: PubMed
      37. Barnes DE, Covinsky KE, Whitmer RA, Kuller LH, Lopez OL, Yaffe K. Predicting risk of dementia in older adults: The late-life dementia risk index. Neurology. 2009 Jul 21; 73(3):173-9.
        View in: PubMed
      38. Cauley JA, Lui LY, Barnes D, Ensrud KE, Zmuda JM, Hillier TA, Hochberg MC, Schwartz AV, Yaffe K, Cummings SR, Newman AB. Successful skeletal aging: a marker of low fracture risk and longevity. The Study of Osteoporotic Fractures (SOF). J Bone Miner Res. 2009 Jan; 24(1):134-43.
        View in: PubMed
      39. Barnes DE, Blackwell T, Stone KL, Goldman SE, Hillier T, Yaffe K. Cognition in older women: the importance of daytime movement. J Am Geriatr Soc. 2008 Sep; 56(9):1658-64.
        View in: PubMed
      40. Mehta KM, Yaffe K, Pérez-Stable EJ, Stewart A, Barnes D, Kurland BF, Miller BL. Race/ethnic differences in AD survival in US Alzheimer's Disease Centers. Neurology. 2008 Apr 1; 70(14):1163-70.
        View in: PubMed
      41. Sudore RL, Landefeld CS, Barnes DE, Lindquist K, Williams BA, Brody R, Schillinger D. An advance directive redesigned to meet the literacy level of most adults: a randomized trial. Patient Educ Couns. 2007 Dec; 69(1-3):165-95.
        View in: PubMed
      42. Yaffe K, Blackwell T, Barnes DE, Ancoli-Israel S, Stone KL. Preclinical cognitive decline and subsequent sleep disturbance in older women. Neurology. 2007 Jul 17; 69(3):237-42.
        View in: PubMed
      43. Barnes DE, Cauley JA, Lui LY, Fink HA, McCulloch C, Stone KL, Yaffe K. Women who maintain optimal cognitive function into old age. J Am Geriatr Soc. 2007 Feb; 55(2):259-64.
        View in: PubMed
      44. Barnes DE, Whitmer RA, Yaffe K. Physical activity and dementia: The need for prevention trials. Exerc Sport Sci Rev. 2007 Jan; 35(1):24-9.
        View in: PubMed
      45. Yaffe K, Barnes D, Lindquist K, Cauley J, Simonsick EM, Penninx B, Satterfield S, Harris T, Cummings SR. Endogenous sex hormone levels and risk of cognitive decline in an older biracial cohort. Neurobiol Aging. 2007 Feb; 28(2):171-8.
        View in: PubMed
      46. Sudore RL, Landefeld CS, Williams BA, Barnes DE, Lindquist K, Schillinger D. Use of a modified informed consent process among vulnerable patients: a descriptive study. J Gen Intern Med. 2006 Aug; 21(8):867-73.
        View in: PubMed
      47. Sink KM, Covinsky KE, Barnes DE, Newcomer RJ, Yaffe K. Caregiver characteristics are associated with neuropsychiatric symptoms of dementia. J Am Geriatr Soc. 2006 May; 54(5):796-803.
        View in: PubMed
      48. Barnes DE, Alexopoulos GS, Lopez OL, Williamson JD, Yaffe K. Depressive symptoms, vascular disease, and mild cognitive impairment: findings from the Cardiovascular Health Study. Arch Gen Psychiatry. 2006 Mar; 63(3):273-9.
        View in: PubMed
      49. Barnes DE, Yaffe K. Vitamin E and donepezil for the treatment of mild cognitive impairment. N Engl J Med. 2005 Sep 1; 353(9):951-2; author reply 951-2.
        View in: PubMed
      50. Barnes DE, Tager IB, Satariano WA, Yaffe K. The relationship between literacy and cognition in well-educated elders. J Gerontol A Biol Sci Med Sci. 2004 Apr; 59(4):390-5.
        View in: PubMed
      51. Barnes DE, Yaffe K, Satariano WA, Tager IB. A longitudinal study of cardiorespiratory fitness and cognitive function in healthy older adults. J Am Geriatr Soc. 2003 Apr; 51(4):459-65.
        View in: PubMed
      52. Yaffe K, Barnes D, Nevitt M, Lui LY, Covinsky K. A prospective study of physical activity and cognitive decline in elderly women: women who walk. Arch Intern Med. 2001 Jul 23; 161(14):1703-8.
        View in: PubMed
      53. Barnes DE, Bero LA. Why review articles on the health effects of passive smoking reach different conclusions. JAMA. 1998 May 20; 279(19):1566-70.
        View in: PubMed
      54. Barnes DE, Bero LA. Scientific quality of original research articles on environmental tobacco smoke. Tob Control. 1997; 6(1):19-26.
        View in: PubMed
      55. Barnes DE, Bero LA. Industry-funded research and conflict of interest: an analysis of research sponsored by the tobacco industry through the Center for Indoor Air Research. J Health Polit Policy Law. 1996; 21(3):515-42.
        View in: PubMed
      56. Glantz SA, Barnes DE, Bero L, Hanauer P, Slade J. Looking through a keyhole at the tobacco industry. The Brown and Williamson documents. JAMA. 1995 Jul 19; 274(3):219-24.
        View in: PubMed
      57. Bero L, Barnes DE, Hanauer P, Slade J, Glantz SA. Lawyer control of the tobacco industry's external research program. The Brown and Williamson documents. JAMA. 1995 Jul 19; 274(3):241-7.
        View in: PubMed
      58. Barnes DE, Hanauer P, Slade J, Bero LA, Glantz SA. Environmental tobacco smoke. The Brown and Williamson documents. JAMA. 1995 Jul 19; 274(3):248-53.
        View in: PubMed
      59. Slade J, Bero LA, Hanauer P, Barnes DE, Glantz SA. Nicotine and addiction. The Brown and Williamson documents. JAMA. 1995 Jul 19; 274(3):225-33.
        View in: PubMed
      60. Hanauer P, Slade J, Barnes DE, Bero L, Glantz SA. Lawyer control of internal scientific research to protect against products liability lawsuits. The Brown and Williamson documents. JAMA. 1995 Jul 19; 274(3):234-40.
        View in: PubMed
      61. Bellows EP, Barnes DE, Csernansky JG. Estimation of haloperidol concentrations in rat striatum after chronic treatment. Brain Res Bull. 1991 May; 26(5):715-9.
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      62. Barnes DE, Robinson B, Csernansky JG, Bellows EP. Sensitization versus tolerance to haloperidol-induced catalepsy: multiple determinants. Pharmacol Biochem Behav. 1990 Aug; 36(4):883-7.
        View in: PubMed
      63. Csernansky JG, Barnes DE, Bellows EP, Lombrozo L. Interrelationships between plasma homovanillic acid and indices of dopamine turnover in multiple brain areas during haloperidol and saline administration. Life Sci. 1990; 46(10):707-13.
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      64. Csernansky JG, Bellows EP, Barnes DE, Lombrozo L. Sensitization versus tolerance to the dopamine turnover-elevating effects of haloperidol: the effect of regular/intermittent dosing. Psychopharmacology (Berl). 1990; 101(4):519-24.
        View in: PubMed
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