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    Devon Lawson

    TitlePostdoc (Werb Lab)
    SchoolUCSF School of Medicine
    Address513 Parnassus Ave
    San Francisco CA 94143
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      Collapse Biography 
      Collapse Awards and Honors
      Department of Defense (DOD)2011 - 2014Congressionally Directed Medical Research Program (CDMRP) BCRP postdoctoral fellowship (11-1-0742)
      NIH NCI2009 - 2011National Cancer Institute Institutional National Research Service Award, T32 CA108462-10
      Graduate Division, UCLA2007 - 2008Graduate student dissertation year fellowship
      NIH2004 - 2007National Institutes of Health/Public Health Services Grant, T32 CA09056

      Collapse Overview 
      Collapse Overview
      Dr. Lawson is a postdoctoral fellow in the laboratory of Dr. Zena Werb at the University of California, San Francisco. She completed her Ph.D. at UCLA in the laboratory of Dr. Owen Witte, where she pioneered methods for the identification of stem cells in the murine prostate and studied their role in prostate cancer initiation and progression. As a postdoc fellow, she has continued studying epithelial cancers, and focused on investigating how cancer cells metastasize, since this phase of the disease represents the biggest challenge to long-term patient survival and quality of life. In particular, she has been applying several new single-cell approaches to study cellular diversity in metastatic breast cancer cells using human patient-derived xenograft (PDX) models of the disease. She has focused on identifying gene expression programs specific to metastasis-initiating cells (MICs), with a long-term goal of using insights gained from these studies to identify new drug targets for directly preventing metastasis initiation and progression.

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      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Lawson DA, Werb Z, Zong Y, Goldstein AS. The Cleared Mammary Fat Pad Transplantation Assay for Mammary Epithelial Organogenesis. Cold Spring Harb Protoc. 2015; 2015(12):pdb.prot078071. PMID: 26631119.
        View in: PubMed
      2. Lawson DA, Bhakta NR, Kessenbrock K, Prummel KD, Yu Y, Takai K, Zhou A, Eyob H, Balakrishnan S, Wang CY, Yaswen P, Goga A, Werb Z. Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells. Nature. 2015 Oct 1; 526(7571):131-5. PMID: 26416748.
        View in: PubMed
      3. Kessenbrock K, Dijkgraaf GJ, Lawson DA, Littlepage LE, Shahi P, Pieper U, Werb Z. A role for matrix metalloproteinases in regulating mammary stem cell function via the Wnt signaling pathway. Cell Stem Cell. 2013 Sep 5; 13(3):300-13. PMID: 23871604; PMCID: PMC3769456.
      4. Plaks V, Brenot A, Lawson DA, Linnemann JR, Van Kappel EC, Wong KC, de Sauvage F, Klein OD, Werb Z. Lgr5-expressing cells are sufficient and necessary for postnatal mammary gland organogenesis. Cell Rep. 2013 Jan 31; 3(1):70-8. PMID: 23352663; PMCID: PMC3563842.
      5. Jiao J, Hindoyan A, Wang S, Tran LM, Goldstein AS, Lawson D, Chen D, Li Y, Guo C, Zhang B, Fazli L, Gleave M, Witte ON, Garraway IP, Wu H. Identification of CD166 as a surface marker for enriching prostate stem/progenitor and cancer initiating cells. PLoS One. 2012; 7(8):e42564. PMID: 22880034; PMCID: PMC3411798.
      6. Littlepage LE, Adler AS, Kouros-Mehr H, Huang G, Chou J, Krig SR, Griffith OL, Korkola JE, Qu K, Lawson DA, Xue Q, Sternlicht MD, Dijkgraaf GJ, Yaswen P, Rugo HS, Sweeney CA, Collins CC, Gray JW, Chang HY, Werb Z. The transcription factor ZNF217 is a prognostic biomarker and therapeutic target during breast cancer progression. Cancer Discov. 2012 Jul; 2(7):638-51. PMID: 22728437; PMCID: PMC3546490.
      7. Lukacs RU, Goldstein AS, Lawson DA, Cheng D, Witte ON. Isolation, cultivation and characterization of adult murine prostate stem cells. Nat Protoc. 2010 Apr; 5(4):702-13. PMID: 20360765; PMCID: PMC2943378.
      8. Lawson DA, Zong Y, Memarzadeh S, Xin L, Huang J, Witte ON. Basal epithelial stem cells are efficient targets for prostate cancer initiation. Proc Natl Acad Sci U S A. 2010 Feb 9; 107(6):2610-5. PMID: 20133806; PMCID: PMC2823887.
      9. Mulholland DJ, Xin L, Morim A, Lawson D, Witte O, Wu H. Lin-Sca-1+CD49fhigh stem/progenitors are tumor-initiating cells in the Pten-null prostate cancer model. Cancer Res. 2009 Nov 15; 69(22):8555-62. PMID: 19887604; PMCID: PMC2783355.
      10. Zong Y, Xin L, Goldstein AS, Lawson DA, Teitell MA, Witte ON. ETS family transcription factors collaborate with alternative signaling pathways to induce carcinoma from adult murine prostate cells. Proc Natl Acad Sci U S A. 2009 Jul 28; 106(30):12465-70. PMID: 19592505.
        View in: PubMed
      11. Goldstein AS, Lawson DA, Cheng D, Sun W, Garraway IP, Witte ON. Trop2 identifies a subpopulation of murine and human prostate basal cells with stem cell characteristics. Proc Natl Acad Sci U S A. 2008 Dec 30; 105(52):20882-7. PMID: 19088204.
        View in: PubMed
      12. Lukacs RU, Lawson DA, Xin L, Zong Y, Garraway I, Goldstein AS, Memarzadeh S, Witte ON. Epithelial stem cells of the prostate and their role in cancer progression. Cold Spring Harb Symp Quant Biol. 2008; 73:491-502. PMID: 19022743.
        View in: PubMed
      13. Lawson DA, Witte ON. Stem cells in prostate cancer initiation and progression. J Clin Invest. 2007 Aug; 117(8):2044-50. PMID: 17671638; PMCID: PMC1934594.
      14. Xin L, Lukacs RU, Lawson DA, Cheng D, Witte ON. Self-renewal and multilineage differentiation in vitro from murine prostate stem cells. Stem Cells. 2007 Nov; 25(11):2760-9. PMID: 17641240.
        View in: PubMed
      15. Lawson DA, Xin L, Lukacs RU, Cheng D, Witte ON. Isolation and functional characterization of murine prostate stem cells. Proc Natl Acad Sci U S A. 2007 Jan 2; 104(1):181-6. PMID: 17185413; PMCID: PMC1716155.
      16. Xin L, Teitell MA, Lawson DA, Kwon A, Mellinghoff IK, Witte ON. Progression of prostate cancer by synergy of AKT with genotropic and nongenotropic actions of the androgen receptor. Proc Natl Acad Sci U S A. 2006 May 16; 103(20):7789-94. PMID: 16682621; PMCID: PMC1458510.
      17. Wang S, Garcia AJ, Wu M, Lawson DA, Witte ON, Wu H. Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiation. Proc Natl Acad Sci U S A. 2006 Jan 31; 103(5):1480-5. PMID: 16432235; PMCID: PMC1345717.
      18. Xin L, Lawson DA, Witte ON. The Sca-1 cell surface marker enriches for a prostate-regenerating cell subpopulation that can initiate prostate tumorigenesis. Proc Natl Acad Sci U S A. 2005 May 10; 102(19):6942-7. PMID: 15860580; PMCID: PMC1087514.
      19. Lawson DA, Xin L, Lukacs R, Xu Q, Cheng D, Witte ON. Prostate stem cells and prostate cancer. Cold Spring Harb Symp Quant Biol. 2005; 70:187-96. PMID: 16869753.
        View in: PubMed
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