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    Dexter Hadley, MD, PhD

    TitleAssistant Professor
    SchoolUCSF School of Medicine
    DepartmentPediatrics
    Address550 16th Street
    San Francisco CA 94158
    EmailDexter.Hadley@ucsf.edu
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      Collapse Biography 
      Collapse Education and Training
      Stanford UniversityResidencyClinical Pathology2012
      Hospital of the University of PennsylvaniaInternshipGeneral Surgery2010
      University of PennsylvaniaM.D.School of Medicine2009
      University of PennsylvaniaPh.D.Genomics & Computational Biology2007
      University of PennsylvaniaM.S.E.Systems Engineering2003
      New College of FL (Honors)B.A.Natural Science1999
      Collapse Awards and Honors
      UCSF2016 - 2018Inaugural Marcus Award for Precision Medicine Innovation
      NIH/NCI2016 - 2018Big Data 2 Knowledge (BD2K) Crowdsourcing Award
      UCSF2015 - 2016RAP Award for Digital Health
      UCSF2015 - 2015Faculty Enrichment Fund
      AMIA2015 - 2015AMIA Design Challenge Competition Winner
      NIH2011 - 2013LRP award in pediatrics
      Penn2009 - 2009Penn Biotech Group Entrepreneurial Competition Winner
      NIH/Penn2003 - 2007Computational Biology Training Grant
      Penn2000 - 2000Center of Excellence Fellowship
      NIH/NHLBI2000 - 2000Medical Student Fellowship

      Collapse Overview 
      Collapse Overview
      Dr. Hadley's expertise is in translating big data into precision medicine and digital health. His work has resulted in an ongoing precision medicine clinical trial for ADHD (ClinicalTrials.gov Identifier: NCT02286817) for a first-in-class, non-stimulant neuromodulator to be targeted across the neuropsychiatric disease spectrum. His laboratory was recently funded by the NIH Big Data to Knowledge initiative to integrate multiple large-scale open databases to allow cross platform computational analyzes powerful enough to discover the functional genes and their related biological pathways that are defective in disease. He received the inaugural UCSF Marcus Award for Precision Medicine to develop a digital health initiative to use smartphones to screen for skin cancer and reduce the mortality of melanoma. In general, the end point of his work is rapid proofs of concept clinical trials in humans that translate into better patient outcomes and reduced morbidity and mortality across the spectrum of disease.

      Collapse Interests
      big data, precision medicine, digital health, crowdsourcing, open data, learning health systems, medical devices, genomics, biomarkers, drug discovery, deep learning

      Collapse ORNG Applications 
      Collapse Websites
      Collapse Featured Presentations
      Collapse Awarded Grants
      Collapse Featured Videos

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Desai A, Connolly JJ, March M, Hou C, Chiavacci R, Kim C, Lyon G, Hadley D, Hakonarson H. Systematic data-querying of large pediatric biorepository identifies novel Ehlers-Danlos Syndrome variant. BMC Musculoskelet Disord. 2016; 17(1):80. PMID: 26879370.
        View in: PubMed
      2. Chen B, Sirota M, Fan-Minogue H, Hadley D, Butte AJ. Relating hepatocellular carcinoma tumor samples and cell lines using gene expression data in translational research. BMC Med Genomics. 2015; 8 Suppl 2:S5. PMID: 26043652; PMCID: PMC4460709.
      3. Waggoner JJ, Sahadeo NS, Brown A, Mohamed-Hadley A, Hadley D, Carrington L, Carrington CV, Pinsky BA. Improved serotype-specific dengue virus detection in Trinidad and Tobago using a multiplex, real-time RT-PCR. Diagn Microbiol Infect Dis. 2015 Feb; 81(2):105-6. PMID: 25533614; PMCID: PMC4297500 [Available on 02/01/16].
      4. Hadley D, Wu ZL, Kao C, Kini A, Mohamed-Hadley A, Thomas K, Vazquez L, Qiu H, Mentch F, Pellegrino R, Kim C, Connolly J, Glessner J, Hakonarson H. The impact of the metabotropic glutamate receptor and other gene family interaction networks on autism. Nat Commun. 2014; 5:4074. PMID: 24927284; PMCID: PMC4059929.
      5. Matsunami N, Hensel CH, Baird L, Stevens J, Otterud B, Leppert T, Varvil T, Hadley D, Glessner JT, Pellegrino R, Kim C, Thomas K, Wang F, Otieno FG, Ho K, Christensen GB, Li D, Prekeris R, Lambert CG, Hakonarson H, Leppert MF. Identification of rare DNA sequence variants in high-risk autism families and their prevalence in a large case/control population. Mol Autism. 2014; 5(1):5. PMID: 24467814; PMCID: PMC4098669.
      6. Sleiman P, Wang D, Glessner J, Hadley D, Gur RE, Cohen N, Li Q, Hakonarson H. GWAS meta analysis identifies TSNARE1 as a novel Schizophrenia / Bipolar susceptibility locus. Sci Rep. 2013; 3:3075. PMID: 24166486; PMCID: PMC3810676.
      7. Matsunami N, Hadley D, Hensel CH, Christensen GB, Kim C, Frackelton E, Thomas K, da Silva RP, Stevens J, Baird L, Otterud B, Ho K, Varvil T, Leppert T, Lambert CG, Leppert M, Hakonarson H. Identification of rare recurrent copy number variants in high-risk autism families and their prevalence in a large ASD population. PLoS One. 2013; 8(1):e52239. PMID: 23341896; PMCID: PMC3544904.
      8. Sanna-Cherchi S, Kiryluk K, Burgess KE, Bodria M, Sampson MG, Hadley D, Nees SN, Verbitsky M, Perry BJ, Sterken R, Lozanovski VJ, Materna-Kiryluk A, Barlassina C, Kini A, Corbani V, Carrea A, Somenzi D, Murtas C, Ristoska-Bojkovska N, Izzi C, Bianco B, Zaniew M, Flogelova H, Weng PL, Kacak N, Giberti S, Gigante M, Arapovic A, Drnasin K, Caridi G, Curioni S, Allegri F, Ammenti A, Ferretti S, Goj V, Bernardo L, Jobanputra V, Chung WK, Lifton RP, Sanders S, State M, Clark LN, Saraga M, Padmanabhan S, Dominiczak AF, Foroud T, Gesualdo L, Gucev Z, Allegri L, Latos-Bielenska A, Cusi D, Scolari F, Tasic V, Hakonarson H, Ghiggeri GM, Gharavi AG. Copy-number disorders are a common cause of congenital kidney malformations. Am J Hum Genet. 2012 Dec 7; 91(6):987-97. PMID: 23159250; PMCID: PMC3516596.
      9. Orlin A, Hadley D, Chang W, Ho AC, Brown G, Kaiser RS, Regillo CD, Godshalk AN, Lier A, Kaderli B, Stambolian D. Association between high-risk disease loci and response to anti-vascular endothelial growth factor treatment for wet age-related macular degeneration. Retina. 2012 Jan; 32(1):4-9. PMID: 21878851.
        View in: PubMed
      10. Elia J, Glessner JT, Wang K, Takahashi N, Shtir CJ, Hadley D, Sleiman PM, Zhang H, Kim CE, Robison R, Lyon GJ, Flory JH, Bradfield JP, Imielinski M, Hou C, Frackelton EC, Chiavacci RM, Sakurai T, Rabin C, Middleton FA, Thomas KA, Garris M, Mentch F, Freitag CM, Steinhausen HC, Todorov AA, Reif A, Rothenberger A, Franke B, Mick EO, Roeyers H, Buitelaar J, Lesch KP, Banaschewski T, Ebstein RP, Mulas F, Oades RD, Sergeant J, Sonuga-Barke E, Renner TJ, Romanos M, Romanos J, Warnke A, Walitza S, Meyer J, Pálmason H, Seitz C, Loo SK, Smalley SL, Biederman J, Kent L, Asherson P, Anney RJ, Gaynor JW, Shaw P, Devoto M, White PS, Grant SF, Buxbaum JD, Rapoport JL, Williams NM, Nelson SF, Faraone SV, Hakonarson H. Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder. Nat Genet. 2012 Jan; 44(1):78-84. PMID: 22138692; PMCID: PMC4310555.
      11. Chen W, Stambolian D, Edwards AO, Branham KE, Othman M, Jakobsdottir J, Tosakulwong N, Pericak-Vance MA, Campochiaro PA, Klein ML, Tan PL, Conley YP, Kanda A, Kopplin L, Li Y, Augustaitis KJ, Karoukis AJ, Scott WK, Agarwal A, Kovach JL, Schwartz SG, Postel EA, Brooks M, Baratz KH, Brown WL, Brucker AJ, Orlin A, Brown G, Ho A, Regillo C, Donoso L, Tian L, Kaderli B, Hadley D, Hagstrom SA, Peachey NS, Klein R, Klein BE, Gotoh N, Yamashiro K, Ferris Iii F, Fagerness JA, Reynolds R, Farrer LA, Kim IK, Miller JW, Cortón M, Carracedo A, Sanchez-Salorio M, Pugh EW, Doheny KF, Brion M, Deangelis MM, Weeks DE, Zack DJ, Chew EY, Heckenlively JR, Yoshimura N, Iyengar SK, Francis PJ, Katsanis N, Seddon JM, Haines JL, Gorin MB, Abecasis GR, Swaroop A. Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. Proc Natl Acad Sci U S A. 2010 Apr 20; 107(16):7401-6. PMID: 20385819; PMCID: PMC2867722.
      12. Hadley D, Orlin A, Brown G, Brucker AJ, Ho AC, Regillo CD, Donoso LA, Tian L, Kaderli B, Stambolian D. Analysis of six genetic risk factors highly associated with AMD in the region surrounding ARMS2 and HTRA1 on chromosome 10, region q26. Invest Ophthalmol Vis Sci. 2010 Apr; 51(4):2191-6. PMID: 19933195.
        View in: PubMed
      13. Bucan M, Abrahams BS, Wang K, Glessner JT, Herman EI, Sonnenblick LI, Alvarez Retuerto AI, Imielinski M, Hadley D, Bradfield JP, Kim C, Gidaya NB, Lindquist I, Hutman T, Sigman M, Kustanovich V, Lajonchere CM, Singleton A, Kim J, Wassink TH, McMahon WM, Owley T, Sweeney JA, Coon H, Nurnberger JI, Li M, Cantor RM, Minshew NJ, Sutcliffe JS, Cook EH, Dawson G, Buxbaum JD, Grant SF, Schellenberg GD, Geschwind DH, Hakonarson H. Genome-wide analyses of exonic copy number variants in a family-based study point to novel autism susceptibility genes. PLoS Genet. 2009 Jun; 5(6):e1000536. PMID: 19557195; PMCID: PMC2695001.
      14. Wang K, Li M, Hadley D, Liu R, Glessner J, Grant SF, Hakonarson H, Bucan M. PennCNV: an integrated hidden Markov model designed for high-resolution copy number variation detection in whole-genome SNP genotyping data. Genome Res. 2007 Nov; 17(11):1665-74. PMID: 17921354; PMCID: PMC2045149.
      15. Hadley D, Murphy T, Valladares O, Hannenhalli S, Ungar L, Kim J, Bucan M. Patterns of sequence conservation in presynaptic neural genes. Genome Biol. 2006; 7(11):R105. PMID: 17096848; PMCID: PMC1794582.
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