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    Diane Tang-Liu, PhD

    TitleProfessor
    SchoolUCSF School of Pharmacy
    DepartmentBioengineering
    Address550 16th Street
    San Francisco CA 94158
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Dahlin A, Geier E, Stocker SL, Cropp CD, Grigorenko E, Bloomer M, Siegenthaler J, Xu L, Basile AS, Tang-Liu DD, Giacomini KM. Gene expression profiling of transporters in the solute carrier and ATP-binding cassette superfamilies in human eye substructures. Mol Pharm. 2013 Feb 4; 10(2):650-63. PMID: 23268600; PMCID: PMC4032224.
      2. Zuniga FI, Loi D, Ling KH, Tang-Liu DD. Idiosyncratic reactions and metabolism of sulfur-containing drugs. Expert Opin Drug Metab Toxicol. 2012 Apr; 8(4):467-85. PMID: 22394356.
        View in: PubMed
      3. Chang-Lin JE, Batoosingh AL, Hollander DA, Schiffman RM, Tang-Liu DD. Aqueous humor penetration of topical bimatoprost 0.01% and bimatoprost 0.03% in rabbits: response to authors. Clin Ophthalmol. 2011; 5:1119-20. PMID: 21887092; PMCID: PMC3162290.
      4. Hunt RH, Armstrong D, Yaghoobi M, James C, Chen Y, Leonard J, Shin JM, Lee E, Tang-Liu D, Sachs G. Predictable prolonged suppression of gastric acidity with a novel proton pump inhibitor, AGN 201904-Z. Aliment Pharmacol Ther. 2008 Jul; 28(2):187-99. PMID: 18445141; PMCID: PMC4505925.
      5. Attar M, Ling KH, Tang-Liu DD, Neamati N, Lee VH. Cytochrome P450 3A expression and activity in the rabbit lacrimal gland: glucocorticoid modulation and the impact on androgen metabolism. Invest Ophthalmol Vis Sci. 2005 Dec; 46(12):4697-706. PMID: 16303967.
        View in: PubMed
      6. Attar M, Yu D, Ni J, Yu Z, Ling KH, Tang-Liu DD. Disposition and biotransformation of the acetylenic retinoid tazarotene in humans. J Pharm Sci. 2005 Oct; 94(10):2246-55. PMID: 16136553.
        View in: PubMed
      7. Yang W, Ni J, Woodward DF, Tang-Liu DD, Ling KH. Enzymatic formation of prostamide F2alpha from anandamide involves a newly identified intermediate metabolite, prostamide H2. J Lipid Res. 2005 Dec; 46(12):2745-51. PMID: 16150817.
        View in: PubMed
      8. Attar M, Shen J, Ling KH, Tang-Liu D. Ophthalmic drug delivery considerations at the cellular level: drug-metabolising enzymes and transporters. Expert Opin Drug Deliv. 2005 Sep; 2(5):891-908. PMID: 16296785.
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      9. Tang-Liu DD, Acheampong A. Ocular pharmacokinetics and safety of ciclosporin, a novel topical treatment for dry eye. Clin Pharmacokinet. 2005; 44(3):247-61. PMID: 15762768.
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      10. Dong JQ, Babusis DM, Welty DF, Acheampong AA, Tang-Liu D, Whitcup SM. Effects of the preservative purite on the bioavailability of brimonidine in the aqueous humor of rabbits. J Ocul Pharmacol Ther. 2004 Aug; 20(4):285-92. PMID: 15321023.
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      11. Weber A, Ni J, Ling KH, Acheampong A, Tang-Liu DD, Burk R, Cravatt BF, Woodward D. Formation of prostamides from anandamide in FAAH knockout mice analyzed by HPLC with tandem mass spectrometry. J Lipid Res. 2004 Apr; 45(4):757-63. PMID: 14729864.
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      12. Yu Z, Yu D, Walker PS, Tang-Liu DD. Tazarotene does not affect the pharmacokinetics and efficacy of a norethindrone/ethinylestradiol oral contraceptive. Clin Pharmacokinet. 2004; 43(10):673-84. PMID: 15244497.
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      13. Tang-Liu DD, Aoki KR, Dolly JO, de Paiva A, Houchen TL, Chasseaud LF, Webber C. Intramuscular injection of 125I-botulinum neurotoxin-complex versus 125I-botulinum-free neurotoxin: time course of tissue distribution. Toxicon. 2003 Oct; 42(5):461-9. PMID: 14529727.
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      14. Jones PH, Burnett RD, Fainaru I, Nadolny P, Walker P, Yu Z, Tang-Liu D, Ganesan TS, Talbot DC, Harris AL, Rustin GJ. A phase 1 study of tazarotene in adults with advanced cancer. Br J Cancer. 2003 Sep 1; 89(5):808-15. PMID: 12942109; PMCID: PMC2394470.
      15. Shen J, Cross ST, Tang-Liu DD, Welty DF. Evaluation of an immortalized retinal endothelial cell line as an in vitro model for drug transport studies across the blood-retinal barrier. Pharm Res. 2003 Sep; 20(9):1357-63. PMID: 14567628.
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      16. Attar M, Dong D, Ling KH, Tang-Liu DD. Cytochrome P450 2C8 and flavin-containing monooxygenases are involved in the metabolism of tazarotenic acid in humans. Drug Metab Dispos. 2003 Apr; 31(4):476-81. PMID: 12642475.
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      17. Woodward DF, Krauss AH, Chen J, Liang Y, Li C, Protzman CE, Bogardus A, Chen R, Kedzie KM, Krauss HA, Gil DW, Kharlamb A, Wheeler LA, Babusis D, Welty D, Tang-Liu DD, Cherukury M, Andrews SW, Burk RM, Garst ME. Pharmacological characterization of a novel antiglaucoma agent, Bimatoprost (AGN 192024). J Pharmacol Exp Ther. 2003 May; 305(2):772-85. PMID: 12606640.
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      18. Yu Z, Sefton J, Lew-Kaya D, Walker P, Yu D, Tang-Liu DD. Pharmacokinetics of tazarotene cream 0.1% after a single dose and after repeat topical applications at clinical or exaggerated application rates in patients with acne vulgaris or photodamaged skin. Clin Pharmacokinet. 2003; 42(10):921-9. PMID: 12885265.
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      19. Small DS, Acheampong A, Reis B, Stern K, Stewart W, Berdy G, Epstein R, Foerster R, Forstot L, Tang-Liu DD. Blood concentrations of cyclosporin a during long-term treatment with cyclosporin a ophthalmic emulsions in patients with moderate to severe dry eye disease. J Ocul Pharmacol Ther. 2002 Oct; 18(5):411-8. PMID: 12419092.
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      20. Acheampong AA, Small D, Baumgarten V, Welty D, Tang-Liu D. Formulation effects on ocular absorption of brimonidine in rabbit eyes. J Ocul Pharmacol Ther. 2002 Aug; 18(4):325-37. PMID: 12222763.
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      21. Acheampong AA, Shackleton M, John B, Burke J, Wheeler L, Tang-Liu D. Distribution of brimonidine into anterior and posterior tissues of monkey, rabbit, and rat eyes. Drug Metab Dispos. 2002 Apr; 30(4):421-9. PMID: 11901096.
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      22. Woodward DF, Krauss AH, Chen J, Lai RK, Spada CS, Burk RM, Andrews SW, Shi L, Liang Y, Kedzie KM, Chen R, Gil DW, Kharlamb A, Archeampong A, Ling J, Madhu C, Ni J, Rix P, Usansky J, Usansky H, Weber A, Welty D, Yang W, Tang-Liu DD, Garst ME, Brar B, Wheeler LA, Kaplan LJ. The pharmacology of bimatoprost (Lumigan). Surv Ophthalmol. 2001 May; 45 Suppl 4:S337-45. PMID: 11434936.
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      23. Berlin RJ, Lee UT, Samples JR, Rich LF, Tang-Liu DD, Sing KA, Steiner RD. Ophthalmic drops causing coma in an infant. J Pediatr. 2001 Mar; 138(3):441-3. PMID: 11241061.
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      24. Small D, Hevy J, Tang-Liu D. Comparison of tear sampling techniques for pharmacokinetics analysis: ofloxacin concentrations in rabbit tears after sampling with schirmer tear strips, capillary tubes, or surgical sponges. J Ocul Pharmacol Ther. 2000 Oct; 16(5):439-46. PMID: 11110035.
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      25. Tang-Liu DD, Matsumoto RM, Usansky JI. Clinical pharmacokinetics and drug metabolism of tazarotene: a novel topical treatment for acne and psoriasis. Clin Pharmacokinet. 1999 Oct; 37(4):273-87. PMID: 10554045.
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      26. Acheampong AA, Shackleton M, Tang-Liu DD, Ding S, Stern ME, Decker R. Distribution of cyclosporin A in ocular tissues after topical administration to albino rabbits and beagle dogs. Curr Eye Res. 1999 Feb; 18(2):91-103. PMID: 10223652.
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      27. Madhu C, Rix P, Nguyen T, Chien DS, Woodward DF, Tang-Liu DD. Penetration of natural prostaglandins and their ester prodrugs and analogs across human ocular tissues in vitro. J Ocul Pharmacol Ther. 1998 Oct; 14(5):389-99. PMID: 9811228.
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      28. Acheampong A, Shackleton M, Lam S, Rudewicz P, Tang-Liu D. Cyclosporine distribution into the conjunctiva, cornea, lacrimal gland, and systemic blood following topical dosing of cyclosporine to rabbit, dog, and human eyes. Adv Exp Med Biol. 1998; 438:1001-4. PMID: 9635002.
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      29. Chien DS, Tang-Liu DD, Woodward DF. Ocular penetration and bioconversion of prostaglandin F2alpha prodrugs in rabbit cornea and conjunctiva. J Pharm Sci. 1997 Oct; 86(10):1180-6. PMID: 9344177.
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      30. Madhu C, Rix P, Small D, Yuan YD, Tang-Liu DD. The use of precision-cut rat lung slices for studying PGF(2a) metabolism. Environ Toxicol Pharmacol. 1997 Sep; 3(4):251-6. PMID: 21781785.
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      31. Madhu C, Duff S, Baumgarten V, Rix P, Small D, Tang-Liu D. Metabolic deesterification of tazarotene in human blood and rat and human liver microsomes. J Pharm Sci. 1997 Aug; 86(8):972-4. PMID: 9269878.
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      32. Acheampong AA, Chien DS, Lam S, Vekich S, Breau A, Usansky J, Harcourt D, Munk SA, Nguyen H, Garst M, Tang-Liu D. Characterization of brimonidine metabolism with rat, rabbit, dog, monkey and human liver fractions and rabbit liver aldehyde oxidase. Xenobiotica. 1996 Oct; 26(10):1035-55. PMID: 8905918.
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      33. Madhu C, Rix PJ, Shackleton MJ, Nguyen TG, Tang-Liu DD. Effect of benzalkonium chloride/EDTA on the ocular bioavailability of ketorolac tromethamine following ocular instillation to normal and de-epithelialized corneas of rabbits. J Pharm Sci. 1996 Apr; 85(4):415-8. PMID: 8901080.
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      34. Angelov OV, Wiese AG, Tang-Liu DD, Acheampong AA, Ismail IM, Brar BS. Preclinical safety profile of brimonidine. Eur J Ophthalmol. 1996 Jan-Mar; 6(1):21-5. PMID: 8744846.
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      35. Acheampong A, Tang-Liu DD. Measurement of brimonidine concentrations in human plasma by a highly sensitive gas chromatography/mass spectrometric assay. J Pharm Biomed Anal. 1995 Jul; 13(8):995-1002. PMID: 8580159.
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      36. Acheampong AA, Shackleton M, Tang-Liu DD. Comparative ocular pharmacokinetics of brimonidine after a single dose application to the eyes of albino and pigmented rabbits. Drug Metab Dispos. 1995 Jul; 23(7):708-12. PMID: 7587958.
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      37. Tang-Liu D, Lambert J, Blancaflor S, Gwon A. Availability of 0.3% ofloxacin ointment and solution in human conjunctiva and aqueous humor. J Ocul Pharmacol Ther. 1995; 11(1):57-63. PMID: 8535958.
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      38. Acheampong AA, Breau A, Shackleton M, Luo W, Lam S, Tang-Liu DD. Comparison of concentration-time profiles of levobunolol and timolol in anterior and posterior ocular tissues of albino rabbits. J Ocul Pharmacol Ther. 1995; 11(4):489-502. PMID: 8574812.
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      39. Hsyu PH, Bowen B, Tang-Liu D. Pharmacokinetics of a novel retinoid AGN 190168 and its metabolite AGN 190299 after intravenous administration of AGN 190168 to rats. Biopharm Drug Dispos. 1994 Jul; 15(5):347-57. PMID: 7981424.
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      40. Tang-Liu DD, Schwob DL, Usansky JI, Gordon YJ. Comparative tear concentrations over time of ofloxacin and tobramycin in human eyes. Clin Pharmacol Ther. 1994 Mar; 55(3):284-92. PMID: 8143394.
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      41. Tang-Liu DD, Richman JB, Weinkam RJ, Takruri H. Effects of four penetration enhancers on corneal permeability of drugs in vitro. J Pharm Sci. 1994 Jan; 83(1):85-90. PMID: 8138917.
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      42. Tang-Liu DD, Richman JB. The effect of pilocarpine on ocular levobunolol absorption from ophthalmic solutions. J Ocul Pharmacol. 1994; 10(4):605-15. PMID: 7714404.
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      43. Tang-Liu DD, Richman JB, Lin P, Selim S. Disposition of SK&F L-190144 in rats and monkeys after oral, intravenous or ocular administration. Biopharm Drug Dispos. 1993 May; 14(4):313-24. PMID: 8499582.
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      44. Ismail IM, Chen CC, Richman JB, Andersen JS, Tang-Liu DD. Comparison of azone and hexamethylene lauramide in toxicologic effects and penetration enhancement of cimetidine in rabbit eyes. Pharm Res. 1992 Jun; 9(6):817-21. PMID: 1409367.
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      45. Borrmann L, Tang-Liu DD, Kann J, Nista J, Lin ET, Frank J. Ofloxacin in human serum, urine, and tear film after topical application. Cornea. 1992 May; 11(3):226-30. PMID: 1587130.
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      46. Gritz DC, McDonnell PJ, Lee TY, Tang-Liu D, Hubbard BB, Gwon A. Topical ofloxacin in the treatment of Pseudomonas keratitis in a rabbit model. Cornea. 1992 Mar; 11(2):143-7. PMID: 1582217.
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      47. Ding S, Chen CC, Salome-Kesslak R, Tang-Liu DD, Himmelstein KJ. Precorneal sampling techniques for ophthalmic gels. J Ocul Pharmacol. 1992; 8(2):151-9. PMID: 1506756.
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      48. Tang-Liu DD, Richman JB, Liu SS. Lenticular uptake and distribution of xenobiotics and amino acids. J Ocul Pharmacol. 1992; 8(3):267-77. PMID: 1453088.
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      49. Chien DS, Homsy JJ, Gluchowski C, Tang-Liu DD. Corneal and conjunctival/scleral penetration of p-aminoclonidine, AGN 190342, and clonidine in rabbit eyes. Curr Eye Res. 1990 Nov; 9(11):1051-9. PMID: 1982760.
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      50. Liu SS, Sandri R, Tang-Liu DD. Systemic pharmacokinetics of acetylenic retinoids in rats. Drug Metab Dispos. 1990 Nov-Dec; 18(6):1071-7. PMID: 1981515.
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      51. Richman J, Zolezio H, Tang-Liu D. Comparison of ofloxacin, gentamicin, and tobramycin concentrations in tears and in vitro MICs for 90% of test organisms. Antimicrob Agents Chemother. 1990 Aug; 34(8):1602-4. PMID: 2221871; PMCID: PMC171882.
      52. Richman JB, Tang-Liu DD. A corneal perfusion device for estimating ocular bioavailability in vitro. J Pharm Sci. 1990 Feb; 79(2):153-7. PMID: 2324964.
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      53. Tang-Liu DD, Sandri R. Ocular biodistribution of clonidine after topical application with ophthalmic rods or solution. J Ocul Pharmacol. 1989; 5(2):133-40. PMID: 2754298.
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      54. Tang-Liu DD, Neff J, Zolezio H, Sandri R. Percutaneous and systemic disposition of hexamethylene lauramide and its penetration enhancement effect on hydrocortisone in a rat sandwich skin-flap model. Pharm Res. 1988 Aug; 5(8):477-81. PMID: 3244654.
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      55. Tang-Liu DD, Burke PJ. The effect of azone on ocular levobunolol absorption: calculating the area under the curve and its standard error using tissue sampling compartments. Pharm Res. 1988 Apr; 5(4):238-41. PMID: 3073384.
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      56. Tang-Liu DD, Shackleton M, Richman JB. Ocular metabolism of levobunolol. J Ocul Pharmacol. 1988; 4(3):269-78. PMID: 3058836.
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      57. Tang-Liu DD, Liu S, Neff J, Sandri R. Disposition of levobunolol after an ophthalmic dose to rabbits. J Pharm Sci. 1987 Oct; 76(10):780-3. PMID: 3323465.
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      58. Tang-Liu DD, Liu S. Relationship between the ocular and systemic disposition of flurbiprofen: the effect of altered protein dynamics at steady state. J Pharmacokinet Biopharm. 1987 Aug; 15(4):387-97. PMID: 3681666.
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      59. Novack GD, Tang-Liu DD, Kelley EP, Liu SS, Shen CD, Duzman E. Plasma levobunolol levels following topical administration with reference to systemic side effects. Ophthalmologica. 1987; 194(4):194-200. PMID: 3306546.
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      60. Blanchard J, Sawers SJ, Jonkman JH, Tang-Liu DD. Comparison of the urinary metabolite profile of caffeine in young and elderly males. Br J Clin Pharmacol. 1985 Feb; 19(2):225-32. PMID: 3986081; PMCID: PMC1463701.
      61. Tang-Liu DD, Liu SS, Weinkam RJ. Ocular and systemic bioavailability of ophthalmic flurbiprofen. J Pharmacokinet Biopharm. 1984 Dec; 12(6):611-26. PMID: 6533296.
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      62. Tang-Liu DD, Tozer TN, Riegelman S. Dependence of renal clearance on urine flow: a mathematical model and its application. J Pharm Sci. 1983 Feb; 72(2):154-8. PMID: 6834253.
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      63. Tang-Liu DD, Williams RL, Riegelman S. Disposition of caffeine and its metabolites in man. J Pharmacol Exp Ther. 1983 Jan; 224(1):180-5. PMID: 6848742.
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      64. Tang-Liu DD, Tozer TN, Riegelman S. Urine flow-dependence of theophylline renal clearance in man. J Pharmacokinet Biopharm. 1982 Aug; 10(4):351-64. PMID: 7153869.
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      65. Tang-Liu DD, Riegelman S. An automated HPLC assay for simultaneous quantitation of methylated xanthines and uric acids in urine. J Chromatogr Sci. 1982 Apr; 20(4):155-9. PMID: 7096523.
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      66. Tang-Liu DD, Williams RL, Riegelman S. Nonlinear theophylline elimination. Clin Pharmacol Ther. 1982 Mar; 31(3):358-69. PMID: 7060318.
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      67. Tang-Liu DD, Riegelman S. Metabolism of theophylline to caffeine in adults. Res Commun Chem Pathol Pharmacol. 1981 Dec; 34(3):371-80. PMID: 7323439.
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