Sign in to see private stats on your profile page — or add photo, interests, videos, mentoring, etc.

    Donald Koblin, PhD, MD

    TitleProfessor Emeritus
    SchoolUCSF School of Medicine
    DepartmentAnesthesia
    Address550 16th Street
    San Francisco CA 94158
    Phone415-750-2069
    vCardDownload vCard

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Koblin DD. Urethane: help or hindrance? Anesth Analg. 2002 Feb; 94(2):241-2. PMID: 11812676.
        View in: PubMed
      2. Eger EI, Halsey MJ, Koblin DD, Laster MJ, Ionescu P, Königsberger K, Fan R, Nguyen BV, Hudlicky T. The convulsant and anesthetic properties of cis-trans isomers of 1,2-dichlorohexafluorocyclobutane and 1,2-dichloroethylene. Anesth Analg. 2001 Oct; 93(4):922-7. PMID: 11574358.
        View in: PubMed
      3. Eger EI, Halsey MJ, Harris RA, Koblin DD, Pohorille A, Sewell JC, Sonner JM, Trudell JR. Hypothesis: volatile anesthetics produce immobility by acting on two sites approximately five carbon atoms apart. Anesth Analg. 1999 Jun; 88(6):1395-400. PMID: 10357351.
        View in: PubMed
      4. Koblin DD, Laster MJ, Ionescu P, Gong D, Eger EI, Halsey MJ, Hudlicky T. Polyhalogenated methyl ethyl ethers: solubilities and anesthetic properties. Anesth Analg. 1999 May; 88(5):1161-7. PMID: 10320188.
        View in: PubMed
      5. Eger EI, Koblin DD, Sonner J, Gong D, Laster MJ, Ionescu P, Halsey MJ, Hudlicky T. Nonimmobilizers and transitional compounds may produce convulsions by two mechanisms. Anesth Analg. 1999 Apr; 88(4):884-92. PMID: 10195542.
        View in: PubMed
      6. Koblin DD, Fang Z, Eger EI, Laster MJ, Gong D, Ionescu P, Halsey MJ, Trudell JR. Minimum alveolar concentrations of noble gases, nitrogen, and sulfur hexafluoride in rats: helium and neon as nonimmobilizers (nonanesthetics) Anesth Analg. 1998 Aug; 87(2):419-24. PMID: 9706943.
        View in: PubMed
      7. Trudell JR, Koblin DD, Eger EI. A molecular description of how noble gases and nitrogen bind to a model site of anesthetic action. Anesth Analg. 1998 Aug; 87(2):411-8. PMID: 9706942.
        View in: PubMed
      8. Yost CS, Hampson AJ, Leonoudakis D, Koblin DD, Bornheim LM, Gray AT. Oleamide potentiates benzodiazepine-sensitive gamma-aminobutyric acid receptor activity but does not alter minimum alveolar anesthetic concentration. Anesth Analg. 1998 Jun; 86(6):1294-300. PMID: 9620523.
        View in: PubMed
      9. Eger EI, Gong D, Koblin DD, Bowland T, Ionescu P, Laster MJ, Weiskopf RB. The effect of anesthetic duration on kinetic and recovery characteristics of desflurane versus sevoflurane, and on the kinetic characteristics of compound A, in volunteers. Anesth Analg. 1998 Feb; 86(2):414-21. PMID: 9459259.
        View in: PubMed
      10. Eger EI, Gong D, Koblin DD, Bowland T, Ionescu P, Laster MJ, Weiskopf RB. Dose-related biochemical markers of renal injury after sevoflurane versus desflurane anesthesia in volunteers. Anesth Analg. 1997 Nov; 85(5):1154-63. PMID: 9356118.
        View in: PubMed
      11. Fang Z, Laster MJ, Ionescu P, Koblin DD, Sonner J, Eger EI, Halsey MJ. Effects of inhaled nonimmobilizer, proconvulsant compounds on desflurane minimum alveolar anesthetic concentration in rats. Anesth Analg. 1997 Nov; 85(5):1149-53. PMID: 9356117.
        View in: PubMed
      12. Griffiths R, Ionescu P, Fang Z, Koblin DD, Eger EI. Enhanced choline acetyltransferase activity does not explain the action of inhaled convulsants. Br J Anaesth. 1997 Sep; 79(3):389-91. PMID: 9389863.
        View in: PubMed
      13. Eger EI, Koblin DD, Laster MJ, Schurig V, Juza M, Ionescu P, Gong D. Minimum alveolar anesthetic concentration values for the enantiomers of isoflurane differ minimally. Anesth Analg. 1997 Jul; 85(1):188-92. PMID: 9212145.
        View in: PubMed
      14. Eger EI, Koblin DD, Harris RA, Kendig JJ, Pohorille A, Halsey MJ, Trudell JR. Hypothesis: inhaled anesthetics produce immobility and amnesia by different mechanisms at different sites. Anesth Analg. 1997 Apr; 84(4):915-8. PMID: 9085981.
        View in: PubMed
      15. Fang Z, Laster MJ, Gong D, Ionescu P, Koblin DD, Sonner J, Eger EI, Halsey MJ. Convulsant activity of nonanesthetic gas combinations. Anesth Analg. 1997 Mar; 84(3):634-40. PMID: 9052316.
        View in: PubMed
      16. Eger EI, Koblin DD, Bowland T, Ionescu P, Laster MJ, Fang Z, Gong D, Sonner J, Weiskopf RB. Nephrotoxicity of sevoflurane versus desflurane anesthesia in volunteers. Anesth Analg. 1997 Jan; 84(1):160-8. PMID: 8989018.
        View in: PubMed
      17. Fang Z, Sonner J, Laster MJ, Ionescu P, Kandel L, Koblin DD, Eger EI, Halsey MJ. Anesthetic and convulsant properties of aromatic compounds and cycloalkanes: implications for mechanisms of narcosis. Anesth Analg. 1996 Nov; 83(5):1097-104. PMID: 8895293.
        View in: PubMed
      18. Eger EI, Ionescu P, Koblin DD, Weiskopf RB. Compound A: solubility in saline and olive oil; destruction by blood. Anesth Analg. 1996 Oct; 83(4):849-53. PMID: 8831333.
        View in: PubMed
      19. Eger EI, Koblin DD. Binding of halothane to serum albumin: relevance to theories of narcosis. Anesthesiology. 1995 Dec; 83(6):1384-5. PMID: 8533948.
        View in: PubMed
      20. Eger EI, Koblin DD. Unitary versus multiple mechanisms of anesthesia. Anesthesiology. 1995 Dec; 83(6):1368. PMID: 8533934.
        View in: PubMed
      21. Lin L, Koblin DD, Wang HH. Effects of halothane on the nicotinic acetylcholine receptor from Torpedo californica. Biochem Pharmacol. 1995 Apr 18; 49(8):1085-9. PMID: 7748189.
        View in: PubMed
      22. Koblin DD. Prolonged asystolic hyperkalemic cardiac arrest with no neurologic sequelae: the lazarus phenomenon arises again. Ann Emerg Med. 1995 Apr; 25(4):562-3. PMID: 7755795.
        View in: PubMed
      23. Koblin DD. Homocystinuria and administration of nitrous oxide. J Clin Anesth. 1995 Mar; 7(2):176. PMID: 7661974.
        View in: PubMed
      24. Koblin DD, Chortkoff BS, Laster MJ, Eger EI, Halsey MJ, Ionescu P. Polyhalogenated and perfluorinated compounds that disobey the Meyer-Overton hypothesis. Anesth Analg. 1994 Dec; 79(6):1043-8. PMID: 7978424.
        View in: PubMed
      25. Chortkoff BS, Laster MJ, Koblin DD, Taheri S, Eger EI, Halsey MJ. Pharmacokinetics do not explain the absence of an anesthetic effect of perfluoropropane or perfluoropentane. Anesth Analg. 1994 Aug; 79(2):234-7. PMID: 7639356.
        View in: PubMed
      26. Liu J, Laster MJ, Koblin DD, Eger EI, Halsey MJ, Taheri S, Chortkoff B. A cutoff in potency exists in the perfluoroalkanes. Anesth Analg. 1994 Aug; 79(2):238-44. PMID: 7639357.
        View in: PubMed
      27. Eger EI, Liu J, Koblin DD, Laster MJ, Taheri S, Halsey MJ, Ionescu P, Chortkoff BS, Hudlicky T. Molecular properties of the "ideal" inhaled anesthetic: studies of fluorinated methanes, ethanes, propanes, and butanes. Anesth Analg. 1994 Aug; 79(2):245-51. PMID: 7639358.
        View in: PubMed
      28. Navarro R, Weiskopf RB, Moore MA, Lockhart S, Eger EI, Koblin D, Lu G, Wilson C. Humans anesthetized with sevoflurane or isoflurane have similar arrhythmic response to epinephrine. Anesthesiology. 1994 Mar; 80(3):545-9. PMID: 7511357.
        View in: PubMed
      29. Koblin DD. The Lazarus phenomenon re-revisited. Anesthesiology. 1993 Dec; 79(6):1438-9. PMID: 8110280.
        View in: PubMed
      30. Taheri S, Laster MJ, Liu J, Eger EI, Halsey MJ, Koblin DD. Anesthesia by n-alkanes not consistent with the Meyer-Overton hypothesis: determinations of the solubilities of alkanes in saline and various lipids. Anesth Analg. 1993 Jul; 77(1):7-11. PMID: 8317750.
        View in: PubMed
      31. Liu J, Laster MJ, Taheri S, Eger EI, Koblin DD, Halsey MJ. Is there a cutoff in anesthetic potency for the normal alkanes? Anesth Analg. 1993 Jul; 77(1):12-8. PMID: 8317717.
        View in: PubMed
      32. Koblin DD, Laster MJ, Liu J. Anaesthetic properties of dimethylthiourea. Br J Anaesth. 1993 Apr; 70(4):456-8. PMID: 8499210.
        View in: PubMed
      33. Koblin DD. Characteristics and implications of desflurane metabolism and toxicity. Anesth Analg. 1992 Oct; 75(4 Suppl):S10-6. PMID: 1524235.
        View in: PubMed
      34. Everman BW, Koblin DD. Aging, chronic administration of ethanol, and acute exposure to nitrous oxide: effects on vitamin B12 and folate status in rats. Mech Ageing Dev. 1992 Mar 1; 62(3):229-43. PMID: 1583909.
        View in: PubMed
      35. Sutton TS, Koblin DD, Gruenke LD, Weiskopf RB, Rampil IJ, Waskell L, Eger EI. Fluoride metabolites after prolonged exposure of volunteers and patients to desflurane. Anesth Analg. 1991 Aug; 73(2):180-5. PMID: 1854033.
        View in: PubMed
      36. Koblin DD, Everman BW. Vitamin B12 and folate status in rats after chronic administration of ethanol and acute exposure to nitrous oxide. Alcohol Clin Exp Res. 1991 Jun; 15(3):543-8. PMID: 1877742.
        View in: PubMed
      37. Taheri S, Halsey MJ, Liu J, Eger EI, Koblin DD, Laster MJ. What solvent best represents the site of action of inhaled anesthetics in humans, rats, and dogs? Anesth Analg. 1991 May; 72(5):627-34. PMID: 2018220.
        View in: PubMed
      38. Lin L, Koblin DD, Wang HH. Saturable binding of anesthetics to nicotinic acetylcholine receptors. A possible mechanism of anesthetic action. Ann N Y Acad Sci. 1991; 625:628-44. PMID: 1647740.
        View in: PubMed
      39. Waldman FM, Koblin DD, Lampe GH, Wauk LZ, Eger EI. Hematologic effects of nitrous oxide in surgical patients. Anesth Analg. 1990 Dec; 71(6):618-24. PMID: 2240634.
        View in: PubMed
      40. Koblin DD, Tomerson BW, Waldman FM, Lampe GH, Wauk LZ, Eger EI. Effect of nitrous oxide on folate and vitamin B12 metabolism in patients. Anesth Analg. 1990 Dec; 71(6):610-7. PMID: 2240633.
        View in: PubMed
      41. Koblin DD, Tomerson BW, Waldman FM. Disruption of folate and vitamin B12 metabolism in aged rats following exposure to nitrous oxide. Anesthesiology. 1990 Sep; 73(3):506-12. PMID: 2393136.
        View in: PubMed
      42. Jones RM, Koblin DD, Cashman JN, Eger EI, Johnson BH, Damask MC. Biotransformation and hepato-renal function in volunteers after exposure to desflurane (I-653). Br J Anaesth. 1990 Apr; 64(4):482-7. PMID: 2334623.
        View in: PubMed
      43. Koblin DD, Tomerson BW. Dimethylthiourea, a hydroxyl radical scavenger, impedes the inactivation of methionine synthase by nitrous oxide in mice. Br J Anaesth. 1990 Feb; 64(2):214-23. PMID: 2107864.
        View in: PubMed
      44. Koblin DD. Nitrous oxide: a cause of cancer or chemotherapeutic adjuvant? Semin Surg Oncol. 1990; 6(3):141-7. PMID: 2189194.
        View in: PubMed
      45. Koblin DD. Nitrous oxide interferes with the aminopyrine breath test. Hepatology. 1989 Oct; 10(4):526-7. PMID: 2506122.
        View in: PubMed
      46. Gauntlett IS, Koblin DD, Fahey MR, Konopka K, Gruenke LD, Waskell L, Eger EI. Metabolism of isoflurane in patients receiving isoniazid. Anesth Analg. 1989 Aug; 69(2):245-9. PMID: 2764294.
        View in: PubMed
      47. Targ AG, Yasuda N, Eger EI, Huang G, Vernice GG, Terrell RC, Koblin DD. Halogenation and anesthetic potency. Anesth Analg. 1989 May; 68(5):599-602. PMID: 2719290.
        View in: PubMed
      48. Koblin DD, Tomerson BW. Methionine synthase activities in mice following acute exposures to ethanol and nitrous oxide. Biochem Pharmacol. 1989 Apr 15; 38(8):1353-8. PMID: 2706023.
        View in: PubMed
      49. Koblin DD, Weiskopf RB, Holmes MA, Konopka K, Rampil IJ, Eger EI, Waskell L. Metabolism of I-653 and isoflurane in swine. Anesth Analg. 1989 Feb; 68(2):147-9. PMID: 2913848.
        View in: PubMed
      50. Roizen MF, Koblin DD, Johnson BH, Eger EI, Bainton CR, Lurz FW. Mechanism of age-related and nitrous oxide-associated anesthetic sensitivity: the role of brain catecholamines. Anesthesiology. 1988 Nov; 69(5):716-20. PMID: 3189918.
        View in: PubMed
      51. Koblin DD, Eger EI, Johnson BH, Konopka K, Waskell L. I-653 resists degradation in rats. Anesth Analg. 1988 Jun; 67(6):534-8. PMID: 3377207.
        View in: PubMed
      52. Gutstein HB, Koblin DD. Craniotomy for tumor in a patient with a bronchopleural fistula: anesthetic considerations. Anesthesiology. 1987 Nov; 67(5):804-6. PMID: 3674484.
        View in: PubMed
      53. Koblin DD, Romanoff ME, Martin DE, Hensley FA, Larach DR, Stauffer RA, Luck JC. Anesthetic management of the parturient receiving amiodarone. Anesthesiology. 1987 Apr; 66(4):551-3. PMID: 3565823.
        View in: PubMed
      54. Koblin DD, Biebuyck JF. Is nitrous oxide a dangerous anesthetic for vitamin B12-deficient subjects? JAMA. 1986 Aug 8; 256(6):716. PMID: 3723770.
        View in: PubMed
      55. Koblin DD. Cortisol following etomidate administration: should we give it the time of day? Anesthesiology. 1985 Jun; 62(6):843-4. PMID: 4003824.
        View in: PubMed
      56. Koblin DD, Lurz FW, O'Connor B, Nelson NT, Eger EI, Bainton CR. Potencies of barbiturates in mice selectively bred for resistance or susceptibility to nitrous oxide anesthesia. Anesth Analg. 1984 Jan; 63(1):35-9. PMID: 6691562.
        View in: PubMed
      57. Koblin DD, Lurz FW, Eger EI. Age-dependent alterations in nitrous oxide requirement of mice. Anesthesiology. 1983 May; 58(5):428-31. PMID: 6837994.
        View in: PubMed
      58. Waskell L, Koblin D, Canova-Davis E. The lipid composition of human liver microsomes. Lipids. 1982 Apr; 17(4):317-20. PMID: 7078361.
        View in: PubMed
      59. Koblin DD, Waskell L, Watson JE, Stokstad EL, Eger EI. Nitrous oxide inactivates methionine synthetase in human liver. Anesth Analg. 1982 Feb; 61(2):75-8. PMID: 7198880.
        View in: PubMed
      60. Koblin DD, O'Connor B, Deady JE, Eger EI. Potencies of convulsant drugs in mice selectively bred for resistance and susceptibility to nitrous oxide anesthesia. Anesthesiology. 1982 Jan; 56(1):25-8. PMID: 7053665.
        View in: PubMed
      61. Koblin DD, Deady JE, Eger EI. Potencies of inhaled anesthetics and alcohol in mice selectively bred for resistance and susceptibility to nitrous oxide anesthesia. Anesthesiology. 1982 Jan; 56(1):18-24. PMID: 7053664.
        View in: PubMed
      62. Koblin DD, Wang HH. Chronic exposure to inhaled anesthetics increases cholesterol content in Acholeplasma laidlawii. Biochim Biophys Acta. 1981 Dec 21; 649(3):717-25. PMID: 6274406.
        View in: PubMed
      63. Koblin DD, Eger EI. Cross-mating of mice selectively bred for resistance or susceptibility to nitrous oxide anesthesia: potencies of nitrous oxide in offspring. Anesth Analg. 1981 Sep; 60(9):646-8. PMID: 7196708.
        View in: PubMed
      64. Koblin DD, Eger EI, Johnson BH, Collins P, Terrell RC, Speers L. Are convulsant gases also anesthetics? Anesth Analg. 1981 Jul; 60(7):464-70. PMID: 7195661.
        View in: PubMed
      65. Deady JE, Koblin DD, Eger EI, Heavner JE, D'Aoust B. Anesthetic potencies and the unitary theory of narcosis. Anesth Analg. 1981 Jun; 60(6):380-4. PMID: 7195159.
        View in: PubMed
      66. Koblin DD, Deady JE. Sensitivity to alcohol in mice with an altered brain fatty acid composition. Life Sci. 1981 Apr 27; 28(17):1889-96. PMID: 7253796.
        View in: PubMed
      67. Eger EI, Koblin DD, Collins PA. Dioxychlorane: a challenge to the correlation of anesthetic potency and lipid solubility. Anesth Analg. 1981 Apr; 60(4):201-3. PMID: 7193998.
        View in: PubMed
      68. Koblin DD, Watson JE, Deady JE, Stokstad EL, Eger EI. Inactivation of methionine synthetase by nitrous oxide in mice. Anesthesiology. 1981 Apr; 54(4):318-24. PMID: 7212332.
        View in: PubMed
      69. Koblin DD, Eger EI, Johnson BH, Collins P, Harper MH, Terrell RC, Speers L. Minimum alveolar concentrations and oil/gas partition coefficients of four anesthetic isomers. Anesthesiology. 1981 Apr; 54(4):314-7. PMID: 6782912.
        View in: PubMed
      70. Koblin DD, Deady JE, Nelson NT, Eger EI, Bainton CR. Mice tolerant to nitrous oxide are not tolerant to barbiturates. Anesth Analg. 1981 Mar; 60(3):138-41. PMID: 7193990.
        View in: PubMed
      71. Koblin DD. Anesthetic requirement in the quaking mouse. Anesthesiology. 1981 Jan; 54(1):17-22. PMID: 7457978.
        View in: PubMed
      72. Koblin DD, Deady JE. Anaesthetic requirement in mice selectively bred for differences in ethanol sensitivity. Br J Anaesth. 1981 Jan; 53(1):5-10. PMID: 7459186.
        View in: PubMed
      73. Koblin DD, Little HJ, Green AR, Daniels S, Smith EB, Paton WD. Brain monoamines and the high pressure neurological syndrome. Neuropharmacology. 1980 Nov; 19(11):1031-8. PMID: 6449674.
        View in: PubMed
      74. Koblin DD, Deady JE, Dong DE, Eger EI. Mice tolerant to nitrous oxide are also tolerant to alcohol. J Pharmacol Exp Ther. 1980 May; 213(2):309-12. PMID: 7365690.
        View in: PubMed
      75. Koblin DD, Dong DE, Deady JE, Eger EI. Selective breeding alters murine resistance to nitrous oxide without alteration in synaptic membrane lipid composition. Anesthesiology. 1980 May; 52(5):401-7. PMID: 7377573.
        View in: PubMed
      76. Koblin DD, Dong DE, Deady JE, Eger EI. Alteration of synaptic membrane fatty acid composition and anesthetic requirement. J Pharmacol Exp Ther. 1980 Mar; 212(3):546-52. PMID: 6244388.
        View in: PubMed
      77. Harper MH, Winter PM, Johnson BH, Koblin DD, Eger EI. Withdrawal convulsions in mice following nitrous oxide. Anesth Analg. 1980 Jan; 59(1):19-21. PMID: 7188661.
        View in: PubMed
      78. Koblin DD, Eger EI. Current concepts: theories of narcosis. N Engl J Med. 1979 Nov 29; 301(22):1222-4. PMID: 228191.
        View in: PubMed
      79. Koblin DD, Dong DE, Eger EI. Tolerance of mice to nitrous oxide. J Pharmacol Exp Ther. 1979 Nov; 211(2):317-25. PMID: 228023.
        View in: PubMed
      80. Koblin DD, Lester HA. Voltage-dependent and voltage-independent blockade of acetylcholine receptors by local anesthetics in Electrophorus electroplaques. Mol Pharmacol. 1979 May; 15(3):559-80. PMID: 492146.
        View in: PubMed
      81. Eger EI, Smith RA, Koblin DD. The concentration effect can be mimicked by a decrease in blood solubility. Anesthesiology. 1978 Oct; 49(4):282-4. PMID: 697085.
        View in: PubMed
      82. Lester HA, Koblin DD, Sheridan RE. Role of voltage-sensitive receptors in nicotinic transmission. Biophys J. 1978 Mar; 21(3):181-94. PMID: 630039; PMCID: PMC1473691.
      83. Koblin DD, Wang HH. The effect of chemical modifiers on the interaction of a spin-labeled local anesthetic with human erythrocyte membranes. Biochem Pharmacol. 1976 Jun 15; 25(12):1405-13. PMID: 7266.
        View in: PubMed
      84. Koblin DD, Pace WD, Wang HH. The penetration of local anesthetics into the red blood cell membrane as studied by fluorescence quenching. Arch Biochem Biophys. 1975 Nov; 171(1):176-82. PMID: 1190792.
        View in: PubMed
      85. Koblin DD, Kaufmann SA, Wang HH. Quenching of 1-anilinonaphthalene-8-sulfonate fluorescence by a spin-labeled local anesthetic: a membrane phenomenon. Biochem Biophys Res Commun. 1973 Aug 21; 53(4):1077-83. PMID: 4748807.
        View in: PubMed
      Donald's Networks
      Related Concepts
      Derived automatically from this person's publications.
      _
      Co-Authors
      People in Profiles who have published with this person.
      _
      Related Authors
      People who share related concepts with this person.
      _
      Back to TOP