Sign in to see private stats on your profile page — or add photo, interests, videos, mentoring, etc.

    Douglas Schmucker, PhD

    TitleProfessor Emeritus
    SchoolUCSF School of Medicine
    DepartmentAnatomy
    Address3333 Calif. St,Laurel Heights
    San Francisco CA 94118
    vCardDownload vCard

      Collapse ORNG Applications 
      Collapse Awarded Grants

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Schmucker DL, Sanchez H. Liver regeneration and aging: a current perspective. Curr Gerontol Geriatr Res. 2011; 2011:526379. PMID: 21912543; PMCID: PMC3170699.
      2. Schmucker DL. Age-related changes in liver structure and function: Implications for disease ? Exp Gerontol. 2005 Aug-Sep; 40(8-9):650-9. PMID: 16102930.
        View in: PubMed
      3. Schmucker DL, Owen RL, Outenreath R, Thoreux K. Basis for the age-related decline in intestinal mucosal immunity. Clin Dev Immunol. 2003 Jun-Dec; 10(2-4):167-72. PMID: 14768948; PMCID: PMC2485420.
      4. Schmucker DL, Owen TM, Issekutz TB, Gonzales L, Wang RK. Expression of lymphocyte homing receptors alpha4beta7 and MAdCAM-l in young and old rats. Exp Gerontol. 2002 Aug-Sep; 37(8-9):1089-95. PMID: 12213559.
        View in: PubMed
      5. Schmucker DL, Sachs H. Quantifying dense bodies and lipofuscin during aging: a morphologist's perspective. Arch Gerontol Geriatr. 2002 May-Jun; 34(3):249-61. PMID: 14764327.
        View in: PubMed
      6. Schmucker DL. Intestinal mucosal immunosenescence in rats. Exp Gerontol. 2002 Jan-Mar; 37(2-3):197-203. PMID: 11772504.
        View in: PubMed
      7. Schmucker DL, Thoreux K, Owen RL. Aging impairs intestinal immunity. Mech Ageing Dev. 2001 Sep 15; 122(13):1397-411. PMID: 11470129.
        View in: PubMed
      8. Thoreux K, Schmucker DL. Kefir milk enhances intestinal immunity in young but not old rats. J Nutr. 2001 Mar; 131(3):807-12. PMID: 11238763.
        View in: PubMed
      9. Schmucker DL. Liver function and phase I drug metabolism in the elderly: a paradox. Drugs Aging. 2001; 18(11):837-51. PMID: 11772124.
        View in: PubMed
      10. Thoreux K, Owen RL, Schmucker DL. Intestinal lymphocyte number, migration and antibody secretion in young and old rats. Immunology. 2000 Sep; 101(1):161-7. PMID: 11012768; PMCID: PMC2327049.
      11. Schmucker DL, Vesell ES. Are the elderly underrepresented in clinical drug trials? J Clin Pharmacol. 1999 Nov; 39(11):1103-8. PMID: 10579140.
        View in: PubMed
      12. Schmucker DL. Efficacy of intraduodenal, oral and parenteral boosting in inducing intestinal mucosal immunity to cholera toxin in rats. Immunol Invest. 1999 Sep-Dec; 28(5-6):339-46. PMID: 10574631.
        View in: PubMed
      13. Schmucker DL. Aging and the liver: an update. J Gerontol A Biol Sci Med Sci. 1998 Sep; 53(5):B315-20. PMID: 9754128.
        View in: PubMed
      14. Vargas JA, Vessey DA, Schmucker DL. Effect of dehydroepiandrosterone (DHEA) on intestinal mucosal immunity in young adult and aging rats. Exp Gerontol. 1998 Aug; 33(5):499-505. PMID: 9762527.
        View in: PubMed
      15. Schmucker DL, Heyworth MF, Owen RL, Daniels CK. Impact of aging on gastrointestinal mucosal immunity. Dig Dis Sci. 1996 Jun; 41(6):1183-93. PMID: 8654151.
        View in: PubMed
      16. Schmucker DL, O'Mahony MS, Vesell ES. Women in clinical drug trials. An update. Clin Pharmacokinet. 1994 Dec; 27(6):411-7. PMID: 7882633.
        View in: PubMed
      17. O'Mahony MS, Schmucker DL. Liver disease in the elderly. Semin Gastrointest Dis. 1994 Oct; 5(4):197-206. PMID: 7834253.
        View in: PubMed
      18. van Bezooijen RL, Wang RK, Lechner MC, Schmucker DL. Aging effects on hepatic NADPH cytochrome P450 reductase, CYP2B1&2, and polymeric immunoglobulin receptor mRNAs in male Fischer 344 rats. Exp Gerontol. 1994 Mar-Apr; 29(2):187-95. PMID: 7517894.
        View in: PubMed
      19. Daniels CK, Perez P, Schmucker DL. Alterations in CD8+ cell distribution in gut-associated lymphoid tissues (GALT) of the aging Fischer 344 rat: a correlated immunohistochemical and flow cytometric analysis. Exp Gerontol. 1993 Nov-Dec; 28(6):549-55. PMID: 8137891.
        View in: PubMed
      20. Schmucker DL, Vesell ES. Underrepresentation of women in clinical drug trials. Clin Pharmacol Ther. 1993 Jul; 54(1):11-5. PMID: 8330458.
        View in: PubMed
      21. Taylor LD, Daniels CK, Schmucker DL. Ageing compromises gastrointestinal mucosal immune response in the rhesus monkey. Immunology. 1992 Apr; 75(4):614-8. PMID: 1592437; PMCID: PMC1384839.
      22. Taylor L, Jones AL, Schmucker DL. Does aging affect liver microtubules? Proc Soc Exp Biol Med. 1992 Apr; 199(4):441-5. PMID: 1549622.
        View in: PubMed
      23. Burwen SJ, Schmucker DL, Jones AL. Subcellular and molecular mechanisms of bile secretion. Int Rev Cytol. 1992; 135:269-313. PMID: 1618608.
        View in: PubMed
      24. Schmucker DL, Wang RK, Snyder D, Strobel H, Marti U. Caloric restriction affects liver microsomal monooxygenases differentially in aging male rats. J Gerontol. 1991 Jan; 46(1):B23-7. PMID: 1898745.
        View in: PubMed
      25. Schmucker DL, Ohta M, Kanai S, Sato Y, Kitani K. Hepatic injury induced by bile salts: correlation between biochemical and morphological events. Hepatology. 1990 Nov; 12(5):1216-21. PMID: 2227821.
        View in: PubMed
      26. Schmucker DL, Woodhouse KW, Wang RK, Wynne H, James OF, McManus M, Kremers P. Effects of age and gender on in vitro properties of human liver microsomal monooxygenases. Clin Pharmacol Ther. 1990 Oct; 48(4):365-74. PMID: 2121408.
        View in: PubMed
      27. Schmucker DL. Hepatocyte fine structure during maturation and senescence. J Electron Microsc Tech. 1990 Feb; 14(2):106-25. PMID: 2406386.
        View in: PubMed
      28. Schmucker DL. Do hepatocytes age? Exp Gerontol. 1990; 25(5):403-12. PMID: 2175269.
        View in: PubMed
      29. Jones AL, Schmucker DL. Isolation of intrahepatic bile duct epithelial cells: clues for function. Gastroenterology. 1989 Nov; 97(5):1337-9. PMID: 2792665.
        View in: PubMed
      30. Daniels CK, Schmucker DL, Jones AL. Hepatic asialoglycoprotein receptor-mediated binding of human polymeric immunoglobulin A. Hepatology. 1989 Feb; 9(2):229-34. PMID: 2912827.
        View in: PubMed
      31. Schmucker DL, Wang RK. Dietary restriction postpones the age-dependent compromise of male rat liver microsomal monooxygenases. Prog Clin Biol Res. 1989; 287:283-8. PMID: 2493654.
        View in: PubMed
      32. Schmucker DL, Daniels CK, Wang RK, Smith K. Mucosal immune response to cholera toxin in ageing rats. I. Antibody and antibody-containing cell response. Immunology. 1988 Aug; 64(4):691-5. PMID: 3169843; PMCID: PMC1384992.
      33. Daniels CK, Schmucker DL, Bazin H, Jones AL. Immunoglobulin A receptor of rat small intestinal enterocytes is unaffected by aging. Gastroenterology. 1988 Jun; 94(6):1432-40. PMID: 3360264.
        View in: PubMed
      34. Daniels CK, Smith KM, Schmucker DL. Asialoorosomucoid hepatobiliary transport is unaltered by the loss of liver asialoglycoprotein receptors in aged rats. Proc Soc Exp Biol Med. 1987 Nov; 186(2):246-50. PMID: 3671364.
        View in: PubMed
      35. Daniels CK, Schmucker DL. Secretory component-dependent binding of immunoglobulin A in the rat, monkey and human: a comparison of intestine and liver. Hepatology. 1987 May-Jun; 7(3):517-21. PMID: 3570162.
        View in: PubMed
      36. Schmucker DL, Wang RK. Effects of aging on the properties of rhesus monkey liver microsomal NADPH-cytochrome c (P-450) reductase. Drug Metab Dispos. 1987 Mar-Apr; 15(2):225-32. PMID: 2882983.
        View in: PubMed
      37. Schmucker DL, Daniels CK. Aging, gastrointestinal infections, and mucosal immunity. J Am Geriatr Soc. 1986 May; 34(5):377-84. PMID: 3514735.
        View in: PubMed
      38. Maloney AG, Schmucker DL, Vessey DS, Wang RK. The effects of aging on the hepatic microsomal mixed-function oxidase system of male and female monkeys. Hepatology. 1986 Mar-Apr; 6(2):282-7. PMID: 3082734.
        View in: PubMed
      39. Jones AL, Hradek GT, Schmucker DL. Intracellular processing of human vs. rat immunoglobulin A in the rat liver. Hepatology. 1985 Nov-Dec; 5(6):1172-8. PMID: 4065823.
        View in: PubMed
      40. Daniels CK, Schmucker DL, Jones AL. Age-dependent loss of dimeric immunoglobulin A receptors in the liver of the Fischer 344 rat. J Immunol. 1985 Jun; 134(6):3855-8. PMID: 3989300.
        View in: PubMed
      41. Schmucker DL. Aging and drug disposition: an update. Pharmacol Rev. 1985 Jun; 37(2):133-48. PMID: 3901045.
        View in: PubMed
      42. Schmucker DL, Sachs HG. Age-dependent alterations in rat ventricular myocardium: a quantitative analysis. Mech Ageing Dev. 1985 Jun; 31(1):89-101. PMID: 2993765.
        View in: PubMed
      43. Schmucker DL, Gilbert R, Jones AL, Hradek GT, Bazin H. Effect of aging on the hepatobiliary transport of dimeric immunoglobulin A in the male Fischer rat. Gastroenterology. 1985 Feb; 88(2):436-43. PMID: 3965333.
        View in: PubMed
      44. Jones AL, Hradek GT, Schmucker DL, Underdown BJ. The fate of polymeric and secretory immunoglobulin A after retrograde infusion into the common bile duct in rats. Hepatology. 1984 Nov-Dec; 4(6):1173-83. PMID: 6500510.
        View in: PubMed
      45. Schmucker DL, Vessey DA, Wang RK, James JL, Maloney A. Age-dependent alterations in the physicochemical properties of rat liver microsomes. Mech Ageing Dev. 1984 Oct 15; 27(2):207-17. PMID: 6492897.
        View in: PubMed
      46. Schmucker DL. Drug disposition in the elderly: a review of the critical factors. J Am Geriatr Soc. 1984 Feb; 32(2):144-9. PMID: 6693701.
        View in: PubMed
      47. Schmucker DL, Wang RK. Drug responses in aged animals. Exp Gerontol. 1984; 19(6):401. PMID: 6519212.
        View in: PubMed
      48. Schmucker DL, Wang RK. Age-dependent alterations in rat liver microsomal NADPH-cytochrome c (P-450) reductase: a qualitative and quantitative analysis. Mech Ageing Dev. 1983 Feb; 21(2):137-56. PMID: 6408319.
        View in: PubMed
      49. Schmucker DL, Wang RK. Age-dependent changes in rat liver microsomal NADPH cytochrome C (P-450) reductase: a kinetic analysis. Exp Gerontol. 1983; 18(4):313-21. PMID: 6321214.
        View in: PubMed
      50. Schmucker DL, Wang RK. Effects of aging and phenobarbital on the rat liver microsomal drug-metabolizing system. Mech Ageing Dev. 1981 Feb; 15(2):189-202. PMID: 6785536.
        View in: PubMed
      51. Schmucker DL, Wang RK. Age-related changes in liver drug metabolism: structure vs function. Proc Soc Exp Biol Med. 1980 Nov; 165(2):178-87. PMID: 7443708.
        View in: PubMed
      52. Jones AL, Schmucker DL, Renston RH, Murakami T. The architecture of bile secretion. A morphological perspective of physiology. Dig Dis Sci. 1980 Aug; 25(8):609-29. PMID: 6995048.
        View in: PubMed
      53. Schmucker DL, Wang RK. Age-related changes in liver drug-metabolizing enzymes. Exp Gerontol. 1980; 15(5):423-31. PMID: 6775972.
        View in: PubMed
      54. Schmucker DL, Wang RK. Effects of animal age and phenobarbital on rat liver glucose-6-phosphatase activity. Exp Gerontol. 1980; 15(1):7-13. PMID: 6250870.
        View in: PubMed
      55. Schmucker DL, Wang RK. Age-related changes in liver drug-metabolizing enzymes. Exp Gerontol. 1980; 15(4):321-9. PMID: 6773795.
        View in: PubMed
      56. Jones AL, Schmucker DL, Mooney JS, Ockner RK, Adler RD. Alterations in hepatic pericanalicular cytoplasm during enhanced bile secretory activity. Lab Invest. 1979 Apr; 40(4):512-7. PMID: 431048.
        View in: PubMed
      57. Schmucker DL. Age-related changes in drug disposition. Pharmacol Rev. 1978 Dec; 30(4):445-56. PMID: 392539.
        View in: PubMed
      58. Jones AL, Schmucker DL, Mooney JS, Adler RD, Ockner RK. A quantitative analysis of hepatic ultrastructure in rats during enhanced bile secretion. Anat Rec. 1978 Oct; 192(2):277-87. PMID: 717801.
        View in: PubMed
      59. Schmucker DL, Mooney JS, Jones AL. Stereological analysis of hepatic fine structure in the Fischer 344 rat. Influence of sublobular location and animal age. J Cell Biol. 1978 Aug; 78(2):319-37. PMID: 690169; PMCID: PMC2110128.
      60. Anthony LE, Schmucker DL, Mooney JS, Jones AL. A quantitative analysis of fine structure and drug metabolism in livers of clofibrate-treated young adult and retired breeder rats. J Lipid Res. 1978 Feb; 19(2):154-65. PMID: 632678.
        View in: PubMed
      61. Jones AL, Schmucker DL. Current concepts of liver structure as related to function. Gastroenterology. 1977 Oct; 73(4 Pt 1):833-51. PMID: 892386.
        View in: PubMed
      62. Jones AL, Schmucker DL, Mooney JS, Adler RD, Ockner RK. Morphometric analysis of rat hepatocytes after total billary obstruction. Gastroenterology. 1976 Dec; 71(6):1050-60. PMID: 992266.
        View in: PubMed
      63. Schmucker DL. Age-related changes in hepatic fine structure: a quantitative analysis. J Gerontol. 1976 Mar; 31(2):135-43. PMID: 1249401.
        View in: PubMed
      64. Schmucker DL, Jones AL, Michielsen CE. An improved system for hemoglobin-free perfusion of isolated rat livers. Lab Invest. 1975 Aug; 33(2):168-75. PMID: 1160341.
        View in: PubMed
      65. Schmucker DL, Jones AL. Hepatic fine structure in young and aging rats treated with oxandrolone: a morphometric study. J Lipid Res. 1975 Mar; 16(2):143-50. PMID: 1127354.
        View in: PubMed
      66. Schmucker DL, Jones AL, Mills ES. Morphometric analysis of the ultrastructural changes in the liver of aging rats. J Gerontol. 1974 Sep; 29(5):506-13. PMID: 4853273.
        View in: PubMed
      Douglas's Networks
      Related Concepts
      Derived automatically from this person's publications.
      _
      Co-Authors
      People in Profiles who have published with this person.
      _
      Related Authors
      People who share related concepts with this person.
      _
      Back to TOP