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Douglas Schmucker, PhD

TitleProfessor Emeritus
SchoolUCSF School of Medicine
DepartmentAnatomy
Address3333 Calif. St,Laurel Heights
San Francisco CA 94118
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    AGING IMPAIRMENT OF GUT MUCOSAL IMMUNITY
    NIH/NIA R01AG007226Jul 1, 1988 - Jun 30, 1992
    Role: Principal Investigator
    INTESTINAL IMMUNE RESPONSE: REGULATION AND MECHANISMS
    NIH P01AM033004Dec 1, 1983 - Nov 30, 1986
    Role: Co-Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Schmucker DL, Sanchez H. Liver regeneration and aging: a current perspective. Curr Gerontol Geriatr Res. 2011; 2011:526379. PMID: 21912543; PMCID: PMC3170699.
    2. Schmucker DL. Age-related changes in liver structure and function: Implications for disease ? Exp Gerontol. 2005 Aug-Sep; 40(8-9):650-9. PMID: 16102930.
      View in: PubMed
    3. Schmucker DL, Owen RL, Outenreath R, Thoreux K. Basis for the age-related decline in intestinal mucosal immunity. Clin Dev Immunol. 2003 Jun-Dec; 10(2-4):167-72. PMID: 14768948; PMCID: PMC2485420.
    4. Schmucker DL, Owen TM, Issekutz TB, Gonzales L, Wang RK. Expression of lymphocyte homing receptors alpha4beta7 and MAdCAM-l in young and old rats. Exp Gerontol. 2002 Aug-Sep; 37(8-9):1089-95. PMID: 12213559.
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    5. Schmucker DL, Sachs H. Quantifying dense bodies and lipofuscin during aging: a morphologist's perspective. Arch Gerontol Geriatr. 2002 May-Jun; 34(3):249-61. PMID: 14764327.
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    6. Schmucker DL. Intestinal mucosal immunosenescence in rats. Exp Gerontol. 2002 Jan-Mar; 37(2-3):197-203. PMID: 11772504.
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    7. Schmucker DL, Thoreux K, Owen RL. Aging impairs intestinal immunity. Mech Ageing Dev. 2001 Sep 15; 122(13):1397-411. PMID: 11470129.
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    8. Thoreux K, Schmucker DL. Kefir milk enhances intestinal immunity in young but not old rats. J Nutr. 2001 Mar; 131(3):807-12. PMID: 11238763.
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    9. Schmucker DL. Liver function and phase I drug metabolism in the elderly: a paradox. Drugs Aging. 2001; 18(11):837-51. PMID: 11772124.
      View in: PubMed
    10. Thoreux K, Owen RL, Schmucker DL. Intestinal lymphocyte number, migration and antibody secretion in young and old rats. Immunology. 2000 Sep; 101(1):161-7. PMID: 11012768; PMCID: PMC2327049.
    11. Schmucker DL, Vesell ES. Are the elderly underrepresented in clinical drug trials? J Clin Pharmacol. 1999 Nov; 39(11):1103-8. PMID: 10579140.
      View in: PubMed
    12. Schmucker DL. Efficacy of intraduodenal, oral and parenteral boosting in inducing intestinal mucosal immunity to cholera toxin in rats. Immunol Invest. 1999 Sep-Dec; 28(5-6):339-46. PMID: 10574631.
      View in: PubMed
    13. Schmucker DL. Aging and the liver: an update. J Gerontol A Biol Sci Med Sci. 1998 Sep; 53(5):B315-20. PMID: 9754128.
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    14. Vargas JA, Vessey DA, Schmucker DL. Effect of dehydroepiandrosterone (DHEA) on intestinal mucosal immunity in young adult and aging rats. Exp Gerontol. 1998 Aug; 33(5):499-505. PMID: 9762527.
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    15. Schmucker DL, Heyworth MF, Owen RL, Daniels CK. Impact of aging on gastrointestinal mucosal immunity. Dig Dis Sci. 1996 Jun; 41(6):1183-93. PMID: 8654151.
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    16. Schmucker DL, O'Mahony MS, Vesell ES. Women in clinical drug trials. An update. Clin Pharmacokinet. 1994 Dec; 27(6):411-7. PMID: 7882633.
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    17. O'Mahony MS, Schmucker DL. Liver disease in the elderly. Semin Gastrointest Dis. 1994 Oct; 5(4):197-206. PMID: 7834253.
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    18. van Bezooijen RL, Wang RK, Lechner MC, Schmucker DL. Aging effects on hepatic NADPH cytochrome P450 reductase, CYP2B1&2, and polymeric immunoglobulin receptor mRNAs in male Fischer 344 rats. Exp Gerontol. 1994 Mar-Apr; 29(2):187-95. PMID: 7517894.
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    19. Daniels CK, Perez P, Schmucker DL. Alterations in CD8+ cell distribution in gut-associated lymphoid tissues (GALT) of the aging Fischer 344 rat: a correlated immunohistochemical and flow cytometric analysis. Exp Gerontol. 1993 Nov-Dec; 28(6):549-55. PMID: 8137891.
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    20. Schmucker DL, Vesell ES. Underrepresentation of women in clinical drug trials. Clin Pharmacol Ther. 1993 Jul; 54(1):11-5. PMID: 8330458.
      View in: PubMed
    21. Taylor LD, Daniels CK, Schmucker D. Ageing compromises gastrointestinal mucosal immune response in the rhesus monkey. Immunology. 1992 Apr; 75(4):614-8. PMID: 1592437; PMCID: PMC1384839.
    22. Taylor L, Jones AL, Schmucker D. Does aging affect liver microtubules? Proc Soc Exp Biol Med. 1992 Apr; 199(4):441-5. PMID: 1549622.
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    23. Burwen SJ, Schmucker D, Jones AL. Subcellular and molecular mechanisms of bile secretion. Int Rev Cytol. 1992; 135:269-313. PMID: 1618608.
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    24. Schmucker D, Wang RK, Snyder D, Strobel H, Marti U. Caloric restriction affects liver microsomal monooxygenases differentially in aging male rats. J Gerontol. 1991 Jan; 46(1):B23-7. PMID: 1898745.
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    25. Schmucker D, Ohta M, Kanai S, Sato Y, Kitani K. Hepatic injury induced by bile salts: correlation between biochemical and morphological events. Hepatology. 1990 Nov; 12(5):1216-21. PMID: 2227821.
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    26. Schmucker D, Woodhouse KW, Wang RK, Wynne H, James OF, McManus M, Kremers P. Effects of age and gender on in vitro properties of human liver microsomal monooxygenases. Clin Pharmacol Ther. 1990 Oct; 48(4):365-74. PMID: 2121408.
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    27. Schmucker D. Hepatocyte fine structure during maturation and senescence. J Electron Microsc Tech. 1990 Feb; 14(2):106-25. PMID: 2406386.
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    28. Schmucker D. Do hepatocytes age? Exp Gerontol. 1990; 25(5):403-12. PMID: 2175269.
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    29. Jones AL, Schmucker D. Isolation of intrahepatic bile duct epithelial cells: clues for function. Gastroenterology. 1989 Nov; 97(5):1337-9. PMID: 2792665.
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    30. Daniels CK, Schmucker D, Jones AL. Hepatic asialoglycoprotein receptor-mediated binding of human polymeric immunoglobulin A. Hepatology. 1989 Feb; 9(2):229-34. PMID: 2912827.
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    31. Schmucker D, Wang RK. Dietary restriction postpones the age-dependent compromise of male rat liver microsomal monooxygenases. Prog Clin Biol Res. 1989; 287:283-8. PMID: 2493654.
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    32. Schmucker D, Daniels CK, Wang RK, Smith K. Mucosal immune response to cholera toxin in ageing rats. I. Antibody and antibody-containing cell response. Immunology. 1988 Aug; 64(4):691-5. PMID: 3169843; PMCID: PMC1384992.
    33. Daniels CK, Schmucker DL, Bazin H, Jones AL. Immunoglobulin A receptor of rat small intestinal enterocytes is unaffected by aging. Gastroenterology. 1988 Jun; 94(6):1432-40. PMID: 3360264.
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    34. Daniels CK, Smith KM, Schmucker DL. Asialoorosomucoid hepatobiliary transport is unaltered by the loss of liver asialoglycoprotein receptors in aged rats. Proc Soc Exp Biol Med. 1987 Nov; 186(2):246-50. PMID: 3671364.
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    35. Daniels CK, Schmucker DL. Secretory component-dependent binding of immunoglobulin A in the rat, monkey and human: a comparison of intestine and liver. Hepatology. 1987 May-Jun; 7(3):517-21. PMID: 3570162.
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    36. Schmucker D, Wang RK. Effects of aging on the properties of rhesus monkey liver microsomal NADPH-cytochrome c (P-450) reductase. Drug Metab Dispos. 1987 Mar-Apr; 15(2):225-32. PMID: 2882983.
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    37. Schmucker DL, Daniels CK. Aging, gastrointestinal infections, and mucosal immunity. J Am Geriatr Soc. 1986 May; 34(5):377-84. PMID: 3514735.
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    38. Maloney AG, Schmucker D, Vessey DS, Wang RK. The effects of aging on the hepatic microsomal mixed-function oxidase system of male and female monkeys. Hepatology. 1986 Mar-Apr; 6(2):282-7. PMID: 3082734.
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    39. Jones AL, Hradek GT, Schmucker DL. Intracellular processing of human vs. rat immunoglobulin A in the rat liver. Hepatology. 1985 Nov-Dec; 5(6):1172-8. PMID: 4065823.
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    40. Schmucker D, Sachs HG. Age-dependent alterations in rat ventricular myocardium: a quantitative analysis. Mech Ageing Dev. 1985 Jun; 31(1):89-101. PMID: 2993765.
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    41. Daniels CK, Schmucker DL, Jones AL. Age-dependent loss of dimeric immunoglobulin A receptors in the liver of the Fischer 344 rat. J Immunol. 1985 Jun; 134(6):3855-8. PMID: 3989300.
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    42. Schmucker DL, Gilbert R, Jones AL, Hradek GT, Bazin H. Effect of aging on the hepatobiliary transport of dimeric immunoglobulin A in the male Fischer rat. Gastroenterology. 1985 Feb; 88(2):436-43. PMID: 3965333.
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    43. Jones AL, Hradek GT, Schmucker DL, Underdown BJ. The fate of polymeric and secretory immunoglobulin A after retrograde infusion into the common bile duct in rats. Hepatology. 1984 Nov-Dec; 4(6):1173-83. PMID: 6500510.
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    44. Schmucker DL, Vessey DA, Wang RK, James JL, Maloney A. Age-dependent alterations in the physicochemical properties of rat liver microsomes. Mech Ageing Dev. 1984 Oct 15; 27(2):207-17. PMID: 6492897.
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    45. Schmucker DL. Drug disposition in the elderly: a review of the critical factors. J Am Geriatr Soc. 1984 Feb; 32(2):144-9. PMID: 6693701.
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    46. Schmucker DL, Wang RK. Drug responses in aged animals. Exp Gerontol. 1984; 19(6):401. PMID: 6519212.
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    47. Schmucker DL, Wang RK. Age-dependent alterations in rat liver microsomal NADPH-cytochrome c (P-450) reductase: a qualitative and quantitative analysis. Mech Ageing Dev. 1983 Feb; 21(2):137-56. PMID: 6408319.
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    48. Schmucker DL, Wang RK. Age-dependent changes in rat liver microsomal NADPH cytochrome C (P-450) reductase: a kinetic analysis. Exp Gerontol. 1983; 18(4):313-21. PMID: 6321214.
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    49. Schmucker DL, Wang RK. Effects of aging and phenobarbital on the rat liver microsomal drug-metabolizing system. Mech Ageing Dev. 1981 Feb; 15(2):189-202. PMID: 6785536.
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    50. Schmucker DL, Wang RK. Age-related changes in liver drug metabolism: structure vs function. Proc Soc Exp Biol Med. 1980 Nov; 165(2):178-87. PMID: 7443708.
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    51. Jones AL, Schmucker DL, Renston RH, Murakami T. The architecture of bile secretion. A morphological perspective of physiology. Dig Dis Sci. 1980 Aug; 25(8):609-29. PMID: 6995048.
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    52. Schmucker DL, Wang RK. Age-related changes in liver drug-metabolizing enzymes. Exp Gerontol. 1980; 15(5):423-31. PMID: 6775972.
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    53. Schmucker DL, Wang RK. Effects of animal age and phenobarbital on rat liver glucose-6-phosphatase activity. Exp Gerontol. 1980; 15(1):7-13. PMID: 6250870.
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    54. Schmucker DL, Wang RK. Age-related changes in liver drug-metabolizing enzymes. Exp Gerontol. 1980; 15(4):321-9. PMID: 6773795.
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    55. Jones AL, Schmucker D, Mooney JS, Ockner RK, Adler RD. Alterations in hepatic pericanalicular cytoplasm during enhanced bile secretory activity. Lab Invest. 1979 Apr; 40(4):512-7. PMID: 431048.
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    56. Schmucker D. Age-related changes in drug disposition. Pharmacol Rev. 1978 Dec; 30(4):445-56. PMID: 392539.
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    57. Jones AL, Schmucker D, Mooney JS, Adler RD, Ockner RK. A quantitative analysis of hepatic ultrastructure in rats during enhanced bile secretion. Anat Rec. 1978 Oct; 192(2):277-87. PMID: 717801.
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    58. Schmucker D, Mooney JS, Jones AL. Stereological analysis of hepatic fine structure in the Fischer 344 rat. Influence of sublobular location and animal age. J Cell Biol. 1978 Aug; 78(2):319-37. PMID: 690169; PMCID: PMC2110128.
    59. Anthony LE, Schmucker D, Mooney JS, Jones AL. A quantitative analysis of fine structure and drug metabolism in livers of clofibrate-treated young adult and retired breeder rats. J Lipid Res. 1978 Feb; 19(2):154-65. PMID: 632678.
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    60. Jones AL, Schmucker D. Current concepts of liver structure as related to function. Gastroenterology. 1977 Oct; 73(4 Pt 1):833-51. PMID: 892386.
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    61. Jones AL, Schmucker D, Mooney JS, Adler RD, Ockner RK. Morphometric analysis of rat hepatocytes after total billary obstruction. Gastroenterology. 1976 Dec; 71(6):1050-60. PMID: 992266.
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    62. Schmucker D. Age-related changes in hepatic fine structure: a quantitative analysis. J Gerontol. 1976 Mar; 31(2):135-43. PMID: 1249401.
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    63. Schmucker D, Jones AL, Michielsen CE. An improved system for hemoglobin-free perfusion of isolated rat livers. Lab Invest. 1975 Aug; 33(2):168-75. PMID: 1160341.
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    64. Schmucker D, Jones AL. Hepatic fine structure in young and aging rats treated with oxandrolone: a morphometric study. J Lipid Res. 1975 Mar; 16(2):143-50. PMID: 1127354.
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    65. Schmucker DL, Jones AL, Mills ES. Morphometric analysis of the ultrastructural changes in the liver of aging rats. J Gerontol. 1974 Sep; 29(5):506-13. PMID: 4853273.
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