Elaine Emmerson, PhD
|The University of Liverpool||B.Sc. Genetics (Hons)||Biological Sciences||2004|
|University of Manchester||Ph.D. Cell Biology||Life Sciences||2010|
|British Society for Research on Ageing||2010||Korenchevsky Award|
|UCSF School of Dentistry Research and Clinical Excellence||2015||1st place, Postdoctoral category|
|British Society for Research on Ageing Annual Meeting||2012||2nd place, selected oral presentations|
Dr. Emmerson graduated from The University of Liverpool in 2004 with a B.Sc. (Hons) in Genetics, where she undertook a project investigating differences between regulatory regions of genes involved in TOR signalling in different Aspergillus species, in the laboratory of Dr. Mark Caddick. Following that she worked as a research technician at the University of Manchester in the laboratory of Professor Gillian Ashcroft, investigating a downstream mediator of estrogen signaling and the influence of the inflammatory response on efficient wound repair, thus beginning her interest in regenerative medicine. In 2006 she began a BBSRC-funded Ph.D. with Prof. Ashcroft, investigating the role of estrogen in delayed cutaneous wound healing in the elderly, receiving her doctorate in 2010. During this time she confirmed that estrogen has numerous beneficial effects on cutaneous healing and post-menopausal women often suffer from chronic, non-healing wounds because of a lack of estrogen (Emmerson et al. 2009). She also explored the use of alternative estrogenic compounds as potential therapeutics in post-menopausal women to accelerate wound healing. Using a murine model she demonstrated the novel therapeutic potential of two estrogenic compounds currently in clinical use in post-menopausal women and a natural dietary estrogen (Hardman et al., 2008; Emmerson et al., 2010). Of importance, the results found during this study have led to the undertaking of a Phase I clinical trial for the topical use of Tamoxifen in wound healing in the elderly (University of Manchester, funded by AgeUK). Following this she began working as a post-doctoral research associate at the University of Manchester with Dr. Matthew Hardman, on a project directly funded by The David Hammond Charitable Foundation, via The Healing Foundation. During this time she revealed the temporal nature of estrogen receptor signalling during cutaneous healing (Emmerson et al. 2013), how estrogen receptor signaling mediates estrogen’s beneficial effects (Campbell et al. 2010; Emmerson et al. 2012; Campbell et al. 2014), how estrogen receptor profiles change with age, and how a specific genetic variation increases the risk of venous ulceration in a UK elderly population. In 2013 she moved to UCSF to begin a Postdoctoral Research Fellow position in the Craniofacial and Mesenchymal Biology department, with Dr. Sarah Knox. During this time she has been investigating the interaction between autonomic innervation, stem cells and tissue regeneration/morphogenesis, using the salivary and lacrimal glands, pancreas and skin as model organs (Finley et al. 2014). Using a combination of in vivo and ex vivo experiments she has identified that parasympathetic innervation regulates tubulogenesis in the developing salivary gland (Nedvetsky et al. 2014) and maintains a progenitor cell population, crucial for morphogenesis and regeneration in the mouse and human salivary gland. Dr. Emmerson is currently investigating the effect of age on organ innervation and stem cells with the view to initiating her own research group in the near future.
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