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    Elaine Emmerson, PhD

    TitlePostdoctoral Scholar
    SchoolUCSF School of Dentistry
    DepartmentCell and Tissue Biology
    Address513 Parnassus Ave
    San Francisco CA 94143
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      Collapse Biography 
      Collapse Education and Training
      The University of LiverpoolB.Sc. Genetics (Hons)Biological Sciences2004
      University of ManchesterPh.D. Cell BiologyLife Sciences2010
      Collapse Awards and Honors
      British Society for Research on Ageing2010Korenchevsky Award
      UCSF School of Dentistry Research and Clinical Excellence20151st place, Postdoctoral category
      British Society for Research on Ageing Annual Meeting20122nd place, selected oral presentations

      Collapse Overview 
      Collapse Overview
      Dr. Emmerson graduated from The University of Liverpool in 2004 with a B.Sc. (Hons) in Genetics, where she undertook a project investigating differences between regulatory regions of genes involved in TOR signalling in different Aspergillus species, in the laboratory of Dr. Mark Caddick. Following that she worked as a research technician at the University of Manchester in the laboratory of Professor Gillian Ashcroft, investigating a downstream mediator of estrogen signaling and the influence of the inflammatory response on efficient wound repair, thus beginning her interest in regenerative medicine. In 2006 she began a BBSRC-funded Ph.D. with Prof. Ashcroft, investigating the role of estrogen in delayed cutaneous wound healing in the elderly, receiving her doctorate in 2010. During this time she confirmed that estrogen has numerous beneficial effects on cutaneous healing and post-menopausal women often suffer from chronic, non-healing wounds because of a lack of estrogen (Emmerson et al. 2009). She also explored the use of alternative estrogenic compounds as potential therapeutics in post-menopausal women to accelerate wound healing. Using a murine model she demonstrated the novel therapeutic potential of two estrogenic compounds currently in clinical use in post-menopausal women and a natural dietary estrogen (Hardman et al., 2008; Emmerson et al., 2010). Of importance, the results found during this study have led to the undertaking of a Phase I clinical trial for the topical use of Tamoxifen in wound healing in the elderly (University of Manchester, funded by AgeUK). Following this she began working as a post-doctoral research associate at the University of Manchester with Dr. Matthew Hardman, on a project directly funded by The David Hammond Charitable Foundation, via The Healing Foundation. During this time she revealed the temporal nature of estrogen receptor signalling during cutaneous healing (Emmerson et al. 2013), how estrogen receptor signaling mediates estrogen’s beneficial effects (Campbell et al. 2010; Emmerson et al. 2012; Campbell et al. 2014), how estrogen receptor profiles change with age, and how a specific genetic variation increases the risk of venous ulceration in a UK elderly population. In 2013 she moved to UCSF to begin a Postdoctoral Research Fellow position in the Craniofacial and Mesenchymal Biology department, with Dr. Sarah Knox. During this time she has been investigating the interaction between autonomic innervation, stem cells and tissue regeneration/morphogenesis, using the salivary and lacrimal glands, pancreas and skin as model organs (Finley et al. 2014). Using a combination of in vivo and ex vivo experiments she has identified that parasympathetic innervation regulates tubulogenesis in the developing salivary gland (Nedvetsky et al. 2014) and maintains a progenitor cell population, crucial for morphogenesis and regeneration in the mouse and human salivary gland. Dr. Emmerson is currently investigating the effect of age on organ innervation and stem cells with the view to initiating her own research group in the near future.

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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Finley JK, Farmer D, Emmerson E, Cruz Pacheco N, Knox SM. Manipulating the murine lacrimal gland. J Vis Exp. 2014; (93):e51970. PMID: 25490187.
        View in: PubMed
      2. Nedvetsky PI, Emmerson E, Finley JK, Ettinger A, Cruz-Pacheco N, Prochazka J, Haddox CL, Northrup E, Hodges C, Mostov KE, Hoffman MP, Knox SM. Parasympathetic innervation regulates tubulogenesis in the developing salivary gland. Dev Cell. 2014 Aug 25; 30(4):449-62. PMID: 25158854; PMCID: PMC4155578.
      3. Campbell L, Emmerson E, Williams H, Saville CR, Krust A, Chambon P, Mace KA, Hardman MJ. Estrogen receptor-alpha promotes alternative macrophage activation during cutaneous repair. J Invest Dermatol. 2014 Sep; 134(9):2447-57. PMID: 24769859.
        View in: PubMed
      4. Emmerson E, Rando G, Meda C, Campbell L, Maggi A, Hardman MJ. Estrogen receptor-mediated signalling in female mice is locally activated in response to wounding. Mol Cell Endocrinol. 2013 Aug 15; 375(1-2):149-56. PMID: 23727624.
        View in: PubMed
      5. Emmerson E, Campbell L, Davies FC, Ross NL, Ashcroft GS, Krust A, Chambon P, Hardman MJ. Insulin-like growth factor-1 promotes wound healing in estrogen-deprived mice: new insights into cutaneous IGF-1R/ERa cross talk. J Invest Dermatol. 2012 Dec; 132(12):2838-48. PMID: 22810305.
        View in: PubMed
      6. Emmerson E, Hardman MJ. The role of estrogen deficiency in skin ageing and wound healing. Biogerontology. 2012 Feb; 13(1):3-20. PMID: 21369728.
        View in: PubMed
      7. Gilliver SC, Emmerson E, Bernhagen J, Hardman MJ. MIF: a key player in cutaneous biology and wound healing. Exp Dermatol. 2011 Jan; 20(1):1-6. PMID: 21158933.
        View in: PubMed
      8. Campbell L, Emmerson E, Davies F, Gilliver SC, Krust A, Chambon P, Ashcroft GS, Hardman MJ. Estrogen promotes cutaneous wound healing via estrogen receptor beta independent of its antiinflammatory activities. J Exp Med. 2010 Aug 30; 207(9):1825-33. PMID: 20733032; PMCID: PMC2931162.
      9. Gilliver SC, Emmerson E, Campbell L, Chambon P, Hardman MJ, Ashcroft GS. 17beta-estradiol inhibits wound healing in male mice via estrogen receptor-alpha. Am J Pathol. 2010 Jun; 176(6):2707-21. PMID: 20448060; PMCID: PMC2877833.
      10. Emmerson E, Campbell L, Ashcroft GS, Hardman MJ. The phytoestrogen genistein promotes wound healing by multiple independent mechanisms. Mol Cell Endocrinol. 2010 Jun 10; 321(2):184-93. PMID: 20193736.
        View in: PubMed
      11. Emmerson E, Campbell L, Ashcroft GS, Hardman MJ. Unique and synergistic roles for 17beta-estradiol and macrophage migration inhibitory factor during cutaneous wound closure are cell type specific. Endocrinology. 2009 Jun; 150(6):2749-57. PMID: 19196797.
        View in: PubMed
      12. Hardman MJ, Emmerson E, Campbell L, Ashcroft GS. Selective estrogen receptor modulators accelerate cutaneous wound healing in ovariectomized female mice. Endocrinology. 2008 Feb; 149(2):551-7. PMID: 17974625.
        View in: PubMed
      13. Fernando DJ, Rajendra J, Emmerson E. A non-healing foot ulcer in a patient with type 2 diabetes mellitus. Eur J Intern Med. 2006 Oct; 17(6):452. PMID: 16962961.
        View in: PubMed
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