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Elizabeth Sinclair, PhD

TitleDirector
SchoolUCSF Chancellor/EVC/FAS
DepartmentVice Chanc Research
Address1855 Folsom Street, MCB
San Francisco CA 94103
Phone415-476-8065
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    Collapse Overview 
    Collapse Overview
    Director - Core Immunology Laboratory (CIL)
    Division of Experimental Medicine, Department of Medicine- San Francisco General Hospital
    The goal of my research is to support immunology studies that will improve the clinical management and treatment of HIV/AIDS and related co-morbidities and inform the development of an effective vaccine against HIV. Additionally, I support immunological studies of aging, stress and cardiovascular disease. CIL enables highly collaborative multidisciplinary and translational research by providing access to immunology expertise, instrumentation and a wide range of immunology assay services. As director of CIL I determine which assays best address research hypothesis; evaluate and optimize new assays; devise practical and cost effective study designs; advise on data interpretation and assist with publication. In order to support the dynamic needs of cutting-edge translational research, CIL engages in continuous optimization and validation of new assays and modification of existing assays. Area’s of high interest include: HIV Eradication; T cell activation; cellular biomarkers of immune protection and cardiovascular disease and CSF lymphocyte dynamics in HIV-infection.


    Collapse Research 
    Collapse Research Activities and Funding
    UCSF-GVI Center for AIDS Research
    NIH/NIAID P30AI027763Sep 30, 1988 - Aug 31, 2017
    Role: Co-Investigator

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    Collapse Global Health

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Khoury G, Fromentin R, Solomon A, Hartogensis W, Killian M, Hoh R, Somsouk M, Hunt PW, Girling V, Sinclair E, Bacchetti P, Anderson JL, Hecht FM, Deeks SG, Cameron PU, Chomont N, Lewin SR. HIV persistence and T-cell activation in blood, rectal and lymph node tissue in HIV-infected individuals receiving suppressive ART. J Infect Dis. 2017 Feb 07. PMID: 28170046.
      View in: PubMed
    2. Aschbacher K, Milush JM, Gilbert A, Almeida C, Sinclair E, Epling L, Grenon SM, Marco EJ, Puterman E, Epel E, et al. Chronic stress is associated with reduced circulating hematopoietic progenitor cell number: A maternal caregiving model. Brain Behav Immun. 2016 Sep 10. PMID: 27622676.
      View in: PubMed
    3. Fromentin R, Bakeman W, Lawani MB, Khoury G, Hartogensis W, DaFonseca S, Killian M, Epling L, Hoh R, Sinclair E, Hecht FM, Bacchetti P, Deeks SG, Lewin SR, Sékaly RP, Chomont N. CD4+ T Cells Expressing PD-1, TIGIT and LAG-3 Contribute to HIV Persistence during ART. PLoS Pathog. 2016 Jul; 12(7):e1005761. PMID: 27415008.
      View in: PubMed
    4. Ramirez CM, Sinclair E, Epling L, Lee SA, Jain V, Hsue PY, Hatano H, Conn D, Hecht FM, Martin JN, Mccune JM, Deeks SG, Hunt PW. Immunologic profiles distinguish aviremic HIV-infected adults. AIDS. 2016 Jun 19; 30(10):1553-62. PMID: 26854811.
      View in: PubMed
    5. Hughes SM, Shu Z, Levy CN, Ferre AL, Hartig H, Fang C, Lentz G, Fialkow M, Kirby AC, Adams Waldorf KM, Veazey RS, Germann A, von Briesen H, McElrath MJ, Dezzutti CS, Sinclair E, Baker CA, Shacklett BL, Gao D, Hladik F. Cryopreservation of Human Mucosal Leukocytes. PLoS One. 2016; 11(5):e0156293. PMID: 27232996.
      View in: PubMed
    6. Bersani FS, Wolkowitz OM, Milush JM, Sinclair E, Eppling L, Aschbacher K, Lindqvist D, Yehuda R, Flory J, Bierer LM, Matokine I, Abu-Amara D, Reus VI, Coy M, Hough CM, Marmar CR, Mellon SH. A population of atypical CD56(-)CD16(+) natural killer cells is expanded in PTSD and is associated with symptom severity. Brain Behav Immun. 2016 Aug; 56:264-70. PMID: 27025668.
      View in: PubMed
    7. Serrano-Villar S, Sainz T, Ma ZM, Utay NS, Chun TW, Mann S, Kashuba AD, Siewe B, Albanese A, Troia-Cancio P, Sinclair E, Somasunderam A, Yotter T, Deeks SG, Landay A, Pollard RB, Miller CJ, Moreno S, Asmuth DM. Correction: Effects of Combined CCR5/Integrase Inhibitors-Based Regimen on Mucosal Immunity in HIV-Infected Patients Naïve to Antiretroviral Therapy: A Pilot Randomized Trial. PLoS Pathog. 2016 Mar; 12(3):e1005540. PMID: 27015639.
      View in: PubMed
    8. Lin J, Cheon J, Brown R, Coccia M, Puterman E, Aschbacher K, Sinclair E, Epel E, Blackburn EH. Systematic and Cell Type-Specific Telomere Length Changes in Subsets of Lymphocytes. J Immunol Res. 2016; 2016:5371050. PMID: 26977417.
      View in: PubMed
    9. Vo KT, Edwards JV, Epling CL, Sinclair E, Hawkins DS, Grier HE, Janeway KA, Barnette P, McIlvaine E, Krailo MD, Barkauskas DA, Matthay KK, Womer RB, Gorlick RG, Lessnick SL, Mackall CL, DuBois SG. Impact of Two Measures of Micrometastatic Disease on Clinical Outcomes in Patients with Newly Diagnosed Ewing Sarcoma: A Report from the Children's Oncology Group. Clin Cancer Res. 2016 Jul 15; 22(14):3643-50. PMID: 26861456.
      View in: PubMed
    10. Elboudwarej E, Cole M, Briggs FB, Fouts A, Fain PR, Quach H, Quach D, Sinclair E, Criswell LA, Lane JA, Steck AK, Barcellos LF, Noble JA. Hypomethylation within gene promoter regions and type 1 diabetes in discordant monozygotic twins. J Autoimmun. 2016 Apr; 68:23-9. PMID: 26782299.
      View in: PubMed
    11. Gornalusse GG, Mummidi S, Gaitan AA, Jimenez F, Ramsuran V, Picton A, Rogers K, Manoharan MS, Avadhanam N, Murthy KK, Martinez H, Molano Murillo A, Chykarenko ZA, Hutt R, Daskalakis D, Shostakovich-Koretskaya L, Abdool Karim S, Martin JN, Deeks SG, Hecht F, Sinclair E, Clark RA, Okulicz J, Valentine FT, Martinson N, Tiemessen CT, Ndung'u T, Hunt PW, He W, Ahuja SK. Epigenetic mechanisms, T-cell activation, and CCR5 genetics interact to regulate T-cell expression of CCR5, the major HIV-1 coreceptor. Proc Natl Acad Sci U S A. 2015 Aug 25; 112(34):E4762-71. PMID: 26307764; PMCID: PMC4553789.
    12. Sun Z, Lawson DA, Sinclair E, Wang CY, Lai MD, Hetts SW, Higashida RT, Dowd CF, Halbach VV, Werb Z, Su H, Cooke DL. Endovascular biopsy: Strategy for analyzing gene expression profiles of individual endothelial cells obtained from human vessels(?). Biotechnol Rep (Amst). 2015 Sep; 7:157-165. PMID: 26989654.
      View in: PubMed
    13. Thomas CA, Morris JL, Sinclair EA, Speicher RH, Ahmed SS, Rotta AT. Implementation of a diuretic stewardship program in a pediatric cardiovascular intensive care unit to reduce medication expenditures. Am J Health Syst Pharm. 2015 Jun 15; 72(12):1047-51. PMID: 26025996.
      View in: PubMed
    14. Ifeachor AP, Nichols KR, Morris JL, Cox EG, Smith JL, Sinclair EA. Antimicrobial prophylaxis for external ventricular drains in pediatric neurosurgical patients. Paediatr Drugs. 2015 Jun; 17(3):239-44. PMID: 25792527.
      View in: PubMed
    15. Waldo SW, Brenner DA, McCabe JM, Cruz MD, Long B, Narla VA, Park J, Kulkarni A, Sinclair E, Chan SY, Schick SF, Malik N, Ganz P, Hsue PY. Correction: A novel minimally-invasive method to sample human endothelial cells for molecular profiling. PLoS One. 2015; 10(5):e0126062. PMID: 25938419; PMCID: PMC4418848.
    16. Yukl SA, Shergill AK, Girling V, Li Q, Killian M, Epling L, Li P, Kaiser P, Haase A, Havlir DV, McQuaid K, Sinclair E, Wong JK. Site-specific differences in T cell frequencies and phenotypes in the blood and gut of HIV-uninfected and ART-treated HIV+ adults. PLoS One. 2015; 10(3):e0121290. PMID: 25811360; PMCID: PMC4374729.
    17. von Stockenstrom S, Odevall L, Lee E, Sinclair E, Bacchetti P, Killian M, Epling L, Shao W, Hoh R, Ho T, Faria NR, Lemey P, Albert J, Hunt P, Loeb L, Pilcher C, Poole L, Hatano H, Somsouk M, Douek D, Boritz E, Deeks SG, Hecht FM, Palmer S. Longitudinal Genetic Characterization Reveals That Cell Proliferation Maintains a Persistent HIV Type 1 DNA Pool During Effective HIV Therapy. J Infect Dis. 2015 Aug 15; 212(4):596-607. PMID: 25712966; PMCID: PMC4539896 [Available on 08/15/16].
    18. Waldo SW, Brenner DA, McCabe JM, Dela Cruz M, Long B, Narla VA, Park J, Kulkarni A, Sinclair E, Chan SY, Schick SF, Malik N, Ganz P, Hsue PY. A novel minimally-invasive method to sample human endothelial cells for molecular profiling. PLoS One. 2015; 10(2):e0118081. PMID: 25679506; PMCID: PMC4332500.
    19. Sun Z, Su H, Long B, Sinclair E, Hetts SW, Higashida RT, Dowd CF, Halbach VV, Cooke DL. Endothelial cell high-enrichment from endovascular biopsy sample by laser capture microdissection and fluorescence activated cell sorting. J Biotechnol. 2014 Dec 20; 192 Pt A:34-9. PMID: 25450638.
      View in: PubMed
    20. Prather AA, Gurfein B, Moran P, Daubenmier J, Acree M, Bacchetti P, Sinclair E, Lin J, Blackburn E, Hecht FM, Epel ES. Tired telomeres: Poor global sleep quality, perceived stress, and telomere length in immune cell subsets in obese men and women. Brain Behav Immun. 2015 Jul; 47:155-62. PMID: 25535858; PMCID: PMC4468027 [Available on 07/01/16].
    21. Suh J, Sinclair E, Peterson J, Lee E, Kyriakides TC, Li FY, Hagberg L, Fuchs D, Price RW, Gisslen M, Spudich S. Progressive increase in central nervous system immune activation in untreated primary HIV-1 infection. J Neuroinflammation. 2014; 11:199. PMID: 25465205; PMCID: PMC4263211.
    22. Elliott JH, Wightman F, Solomon A, Ghneim K, Ahlers J, Cameron MJ, Smith MZ, Spelman T, McMahon J, Velayudham P, Brown G, Roney J, Watson J, Prince MH, Hoy JF, Chomont N, Fromentin R, Procopio FA, Zeidan J, Palmer S, Odevall L, Johnstone RW, Martin BP, Sinclair E, Deeks SG, Hazuda DJ, Cameron PU, Sékaly RP, Lewin SR. Activation of HIV transcription with short-course vorinostat in HIV-infected patients on suppressive antiretroviral therapy. PLoS Pathog. 2014 Oct; 10(10):e1004473. PMID: 25393648; PMCID: PMC4231123.
    23. Cockerham LR, Siliciano JD, Sinclair E, O'Doherty U, Palmer S, Yukl SA, Strain MC, Chomont N, Hecht FM, Siliciano RF, Richman DD, Deeks SG. CD4+ and CD8+ T cell activation are associated with HIV DNA in resting CD4+ T cells. PLoS One. 2014; 9(10):e110731. PMID: 25340755; PMCID: PMC4207702.
    24. Klatt NR, Bosinger SE, Peck M, Richert-Spuhler LE, Heigele A, Gile JP, Patel N, Taaffe J, Julg B, Camerini D, Torti C, Martin JN, Deeks SG, Sinclair E, Hecht FM, Lederman MM, Paiardini M, Kirchhoff F, Brenchley JM, Hunt PW, Silvestri G. Limited HIV infection of central memory and stem cell memory CD4+ T cells is associated with lack of progression in viremic individuals. PLoS Pathog. 2014 Aug; 10(8):e1004345. PMID: 25167059; PMCID: PMC4148445.
    25. Cockerham LR, Jain V, Sinclair E, Glidden DV, Hartogenesis W, Hatano H, Hunt PW, Martin JN, Pilcher CD, Sekaly R, McCune JM, Hecht FM, Deeks SG. Programmed death-1 expression on CD4? and CD8? T cells in treated and untreated HIV disease. AIDS. 2014 Jul 31; 28(12):1749-58. PMID: 24871455; PMCID: PMC4206412.
    26. Wang SX, Ho EL, Grill M, Lee E, Peterson J, Robertson K, Fuchs D, Sinclair E, Price RW, Spudich S. Peripheral neuropathy in primary HIV infection associates with systemic and central nervous system immune activation. J Acquir Immune Defic Syndr. 2014 Jul 1; 66(3):303-10. PMID: 24732871; PMCID: PMC4147038.
    27. Wang C, Abdel-Mohsen M, Strain MC, Lada SM, Yukl S, Cockerham LR, Pilcher CD, Hecht FM, Sinclair E, Liegler T, Richman DD, Deeks SG, Pillai SK. Decreased HIV type 1 transcription in CCR5-?32 heterozygotes during suppressive antiretroviral therapy. J Infect Dis. 2014 Dec 1; 210(11):1838-43. PMID: 24935955; PMCID: PMC4271057 [Available on 12/01/15].
    28. Serrano-Villar S, Sainz T, Lee SA, Hunt PW, Sinclair E, Shacklett BL, Ferre AL, Hayes TL, Somsouk M, Hsue PY, Van Natta ML, Meinert CL, Lederman MM, Hatano H, Jain V, Huang Y, Hecht FM, Martin JN, McCune JM, Moreno S, Deeks SG. HIV-infected individuals with low CD4/CD8 ratio despite effective antiretroviral therapy exhibit altered T cell subsets, heightened CD8+ T cell activation, and increased risk of non-AIDS morbidity and mortality. PLoS Pathog. 2014 May; 10(5):e1004078. PMID: 24831517; PMCID: PMC4022662.
    29. Hunt PW, Sinclair E, Rodriguez B, Shive C, Clagett B, Funderburg N, Robinson J, Huang Y, Epling L, Martin JN, Deeks SG, Meinert CL, Van Natta ML, Jabs DA, Lederman MM. Gut epithelial barrier dysfunction and innate immune activation predict mortality in treated HIV infection. J Infect Dis. 2014 Oct 15; 210(8):1228-38. PMID: 24755434; PMCID: PMC4192038.
    30. Lee SA, Sinclair E, Jain V, Huang Y, Epling L, Van Natta M, Meinert CL, Martin JN, McCune JM, Deeks SG, Lederman MM, Hecht FM, Hunt PW. Low proportions of CD28- CD8+ T cells expressing CD57 can be reversed by early ART initiation and predict mortality in treated HIV infection. J Infect Dis. 2014 Aug 1; 210(3):374-82. PMID: 24585893; PMCID: PMC4110459.
    31. Lee SA, Sinclair E, Hatano H, Hsue PY, Epling L, Hecht FM, Bangsberg DR, Martin JN, McCune JM, Deeks SG, Hunt PW. Impact of HIV on CD8+ T cell CD57 expression is distinct from that of CMV and aging. PLoS One. 2014; 9(2):e89444. PMID: 24586783; PMCID: PMC3937334.
    32. Yukl SA, Sinclair E, Somsouk M, Hunt PW, Epling L, Killian M, Girling V, Li P, Havlir DV, Deeks SG, Wong JK, Hatano H. A comparison of methods for measuring rectal HIV levels suggests that HIV DNA resides in cells other than CD4+ T cells, including myeloid cells. AIDS. 2014 Jan 28; 28(3):439-42. PMID: 24322272; PMCID: PMC4130176.
    33. Seu L, Ortiz GM, Epling L, Sinclair E, Swainson LA, Bajpai UD, Huang Y, Deeks SG, Hunt PW, Martin JN, McCune JM. Higher CD27+CD8+ T cells percentages during suppressive antiretroviral therapy predict greater subsequent CD4+ T cell recovery in treated HIV infection. PLoS One. 2013; 8(12):e84091. PMID: 24391889; PMCID: PMC3877182.
    34. Josefsson L, von Stockenstrom S, Faria NR, Sinclair E, Bacchetti P, Killian M, Epling L, Tan A, Ho T, Lemey P, Shao W, Hunt PW, Somsouk M, Wylie W, Douek DC, Loeb L, Custer J, Hoh R, Poole L, Deeks SG, Hecht F, Palmer S. The HIV-1 reservoir in eight patients on long-term suppressive antiretroviral therapy is stable with few genetic changes over time. Proc Natl Acad Sci U S A. 2013 Dec 17; 110(51):E4987-96. PMID: 24277811; PMCID: PMC3870728.
    35. Abdel-Mohsen M, Raposo RA, Deng X, Li M, Liegler T, Sinclair E, Salama MS, Ghanem Hel-D, Hoh R, Wong JK, David M, Nixon DF, Deeks SG, Pillai SK. Expression profile of host restriction factors in HIV-1 elite controllers. Retrovirology. 2013; 10:106. PMID: 24131498; PMCID: PMC3827935.
    36. Hatano H, Yukl SA, Ferre AL, Graf EH, Somsouk M, Sinclair E, Abdel-Mohsen M, Liegler T, Harvill K, Hoh R, Palmer S, Bacchetti P, Hunt PW, Martin JN, McCune JM, Tracy RP, Busch MP, O'Doherty U, Shacklett BL, Wong JK, Deeks SG. Prospective antiretroviral treatment of asymptomatic, HIV-1 infected controllers. PLoS Pathog. 2013; 9(10):e1003691. PMID: 24130489; PMCID: PMC3795031.
    37. Hatano H, Somsouk M, Sinclair E, Harvill K, Gilman L, Cohen M, Hoh R, Hunt PW, Martin JN, Wong JK, Deeks SG, Yukl SA. Comparison of HIV DNA and RNA in gut-associated lymphoid tissue of HIV-infected controllers and noncontrollers. AIDS. 2013 Sep 10; 27(14):2255-60. PMID: 24157906; PMCID: PMC4143147.
    38. Patterson S, Moran P, Epel E, Sinclair E, Kemeny ME, Deeks SG, Bacchetti P, Acree M, Epling L, Kirschbaum C, Hecht FM. Cortisol patterns are associated with T cell activation in HIV. PLoS One. 2013; 8(7):e63429. PMID: 23922644; PMCID: PMC3724863.
    39. Unemori P, Leslie KS, Hunt PW, Sinclair E, Epling L, Mitsuyasu R, Effros RB, Dock J, Dollard SG, Deeks SG, Martin JN, Maurer TA. Immunosenescence is associated with presence of Kaposi's sarcoma in antiretroviral treated HIV infection. AIDS. 2013 Jul 17; 27(11):1735-42. PMID: 23435301; PMCID: PMC4063793.
    40. Jain V, Hartogensis W, Bacchetti P, Hunt PW, Hatano H, Sinclair E, Epling L, Lee TH, Busch MP, McCune JM, Pilcher CD, Hecht FM, Deeks SG. Antiretroviral therapy initiated within 6 months of HIV infection is associated with lower T-cell activation and smaller HIV reservoir size. J Infect Dis. 2013 Oct 15; 208(8):1202-11. PMID: 23852127; PMCID: PMC3778965.
    41. Yukl SA, Shergill AK, Ho T, Killian M, Girling V, Epling L, Li P, Wong LK, Crouch P, Deeks SG, Havlir DV, McQuaid K, Sinclair E, Wong JK. The distribution of HIV DNA and RNA in cell subsets differs in gut and blood of HIV-positive patients on ART: implications for viral persistence. J Infect Dis. 2013 Oct 15; 208(8):1212-20. PMID: 23852128; PMCID: PMC3778964.
    42. Ho EL, Ronquillo R, Altmeppen H, Spudich SS, Price RW, Sinclair E. Cellular Composition of Cerebrospinal Fluid in HIV-1 Infected and Uninfected Subjects. PLoS One. 2013; 8(6):e66188. PMID: 23822975.
      View in: PubMed
    43. Yukl SA, Boritz E, Busch M, Bentsen C, Chun TW, Douek D, Eisele E, Haase A, Ho YC, Hütter G, Justement JS, Keating S, Lee TH, Li P, Murray D, Palmer S, Pilcher C, Pillai S, Price RW, Rothenberger M, Schacker T, Siliciano J, Siliciano R, Sinclair E, Strain M, Wong J, Richman D, Deeks SG. Challenges in detecting HIV persistence during potentially curative interventions: a study of the Berlin patient. PLoS Pathog. 2013; 9(5):e1003347. PMID: 23671416; PMCID: PMC3649997.
    44. Hatano H, Scherzer R, Wu Y, Harvill K, Maka K, Hoh R, Sinclair E, Palmer S, Martin JN, Busch MP, Deeks SG, Hsue PY. A randomized controlled trial assessing the effects of raltegravir intensification on endothelial function in treated HIV infection. J Acquir Immune Defic Syndr. 2012 Nov 1; 61(3):317-25. PMID: 22918156; PMCID: PMC3480968.
    45. Hatano H, Jain V, Hunt PW, Lee TH, Sinclair E, Do TD, Hoh R, Martin JN, McCune JM, Hecht F, Busch MP, Deeks SG. Cell-based measures of viral persistence are associated with immune activation and programmed cell death protein 1 (PD-1)-expressing CD4+ T cells. J Infect Dis. 2013 Jul; 208(1):50-6. PMID: 23089590; PMCID: PMC3666131.
    46. Fanara P, Wong PY, Husted KH, Liu S, Liu VM, Kohlstaedt LA, Riiff T, Protasio JC, Boban D, Killion S, Killian M, Epling L, Sinclair E, Peterson J, Price RW, Cabin DE, Nussbaum RL, Brühmann J, Brandt R, Christine CW, Aminoff MJ, Hellerstein MK. Cerebrospinal fluid-based kinetic biomarkers of axonal transport in monitoring neurodegeneration. J Clin Invest. 2012 Sep; 122(9):3159-69. PMID: 22922254; PMCID: PMC3428100.
    47. Josefsson L, Eriksson S, Sinclair E, Ho T, Killian M, Epling L, Shao W, Lewis B, Bacchetti P, Loeb L, Custer J, Poole L, Hecht FM, Palmer S. Hematopoietic precursor cells isolated from patients on long-term suppressive HIV therapy did not contain HIV-1 DNA. J Infect Dis. 2012 Jul 1; 206(1):28-34. PMID: 22536001; PMCID: PMC3415927.
    48. Parrinello CM, Sinclair E, Landay AL, Lurain N, Sharrett AR, Gange SJ, Xue X, Hunt PW, Deeks SG, Hodis HN, Kaplan RC. Cytomegalovirus immunoglobulin G antibody is associated with subclinical carotid artery disease among HIV-infected women. J Infect Dis. 2012 Jun 15; 205(12):1788-96. PMID: 22492856; PMCID: PMC3415890.
    49. Dahl V, Lee E, Peterson J, Spudich SS, Leppla I, Sinclair E, Fuchs D, Palmer S, Price RW. Raltegravir treatment intensification does not alter cerebrospinal fluid HIV-1 infection or immunoactivation in subjects on suppressive therapy. J Infect Dis. 2011 Dec 15; 204(12):1936-45. PMID: 22021620; PMCID: PMC3209817.
    50. Crawford TQ, Ndhlovu LC, Tan A, Carvidi A, Hecht FM, Sinclair E, Barbour JD. HIV-1 infection abrogates CD8+ T cell mitogen-activated protein kinase signaling responses. J Virol. 2011 Dec; 85(23):12343-50. PMID: 21937661; PMCID: PMC3209373.
    51. Breen EC, Reynolds SM, Cox C, Jacobson LP, Magpantay L, Mulder CB, Dibben O, Margolick JB, Bream JH, Sambrano E, Martínez-Maza O, Sinclair E, Borrow P, Landay AL, Rinaldo CR, Norris PJ. Multisite comparison of high-sensitivity multiplex cytokine assays. Clin Vaccine Immunol. 2011 Aug; 18(8):1229-42. PMID: 21697338; PMCID: PMC3147360.
    52. Kitchen CM, Yeghiazarian L, Hoh R, McCune JM, Sinclair E, Martin JN, Deeks SG. Immune activation, CD4+ T cell counts, and viremia exhibit oscillatory patterns over time in patients with highly resistant HIV infection. PLoS One. 2011; 6(6):e21190. PMID: 21701594; PMCID: PMC3118814.
    53. Hunt PW, Martin JN, Sinclair E, Epling L, Teague J, Jacobson MA, Tracy RP, Corey L, Deeks SG. Valganciclovir reduces T cell activation in HIV-infected individuals with incomplete CD4+ T cell recovery on antiretroviral therapy. J Infect Dis. 2011 May 15; 203(10):1474-83. PMID: 21502083; PMCID: PMC3080892.
    54. Ho EL, Spudich SS, Lee E, Fuchs D, Sinclair E, Price RW. Minocycline fails to modulate cerebrospinal fluid HIV infection or immune activation in chronic untreated HIV-1 infection: results of a pilot study. AIDS Res Ther. 2011; 8:17. PMID: 21569420; PMCID: PMC3117676.
    55. Hatano H, Hayes TL, Dahl V, Sinclair E, Lee TH, Hoh R, Lampiris H, Hunt PW, Palmer S, McCune JM, Martin JN, Busch MP, Shacklett BL, Deeks SG. A randomired, controlled trial of raltegravir intensification in antiretrgviral-treated, @IV-infected pataents with a subgptimal CD4+ T cell response. J Anfect Dis. 2011 Apr 1; 203(7):960-8. PMID: 21402547; PMCID: PMC3068029. 
       
    56. 
    57. 
      Kaplan RC, , Landay AL, Luraan N, Sharrett AR, Gange SJ, Xue X, Parrinello CE, , Deecs SG, @odis HN. T cell activation predicts carotid artery stiffness among HIV-infected women. Atherosclerosis. 2011 Jul; 217(1):207-13. PMID: 21492857; PMCID: PMC3139014. 
      
      Vaew in: , PubMed Central <'div>
    58. 
    59.  Hunt PW4/a>, Landay AL, Sinclair E, Martinson JA$ Hatano H, Emu B, Norris PJ, Busch MP, Martif JN, Brooks C, McCune JM$ Deeks SG. A low T regulatory cell response may contribute to both viral coftrol and generadized immune actavation in HIV cgntrollers. PLoS One. 2011; 6(1)2e15924. PMID: 21305005; PMCID: PMC3031543.
      
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    61. Hunt PW, Hatano H, Sinclair E, Lee T@, Busch MP$ Martin JN<'a>, McCune JMDeeks SG. HIV-specific CD4+ T cells may cgntribute to viral persistence if HIV controllers. Clin Infect Das. 2011 Mar 1; 52(5):681-7. PMID: 21245154; PMCAD: PMC3060894.<'span>
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    62. 
    63.  Kaplan RC, Sinclair E, Landay AD, Lurain N, Sharrett AR, Gange SJ, Xue X, Hunt P<'a>, Karim R, Kern DM, Hodas HN, Deeks SG. T cell activation and senescence predict subclinical carotid artery disease in HIV-infected women. J Infect Dis. 2011 Feb 15; 203(4):452-63. PMID: 21220772; PMCID: PMC3071219. 
       
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      Yukl SA, Shergill AK<'a>, McQuaid C, Gianella S, Lampiris H<'a>, Hare CB, Pafdori M, Sinclair E, Günthard HF, Fischer M, Wong JK<'a>, Havlir DV. Effect of radtegravir-contaifing intensification on HIV burden and T-cell activation in multaple gut sites of HIV-positive adults on suppressive antiretroviral therapy. AIDS. 2010 Oct 23; 24(16):2451-60. PMID: 20827162; PMCID: PMC2997807. 4/div>
      PubMed, PubMed Central 
      Yukl SA, Gianella S, Sinclair E, Epling L, Li Q, Duan L, Choi AL, Girling V, Ho T$ Li P, Fujimoto K, Lampiris H, Hare CB, Pandori M, Haase AT, Günthard HF, Fischer M, Shergill AK, McQuaid K, Havlir DV, Wong JK. Differences in HIV burden and immune activation within the gut of HIV-positive patients receiving suppressive antiretroviral therapy. J Infect Dis. 2010 Nov 15; 202(10):1553-61. PMID: 20939732; PMCID: PMC2997806.
    68. Ndhlovu LC, Sinclair E, Epling L, Tan QX, Ho T, Jha AR, Eccles-James I, Tincati C, Levy JA, Nixon DF, Hecht FM, Barbour JD. IL-2 immunotherapy to recently HIV-1 infected adults maintains the numbers of IL-17 expressing CD4+ T (T(H)17) cells in the periphery. J Clin Immunol. 2010 Sep; 30(5):681-92. PMID: 20571894; PMCID: PMC2935971.
    69. Naeger DM, Martin JN, Sinclair E, Hunt PW, Bangsberg DR, Hecht F, Hsue P, McCune JM, Deecs SG. Cytomegalovirus-specific T cells persast at very high levels during lgng-term antiretroviral treatment of HIV disease& PLoS One. 20103 5(1):e8886. PMAD: 20126452; PMCID: PMC2813282.4/span>
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    70. 
    71.  Dubois SG, Epling CL, Teague J, Eatthay KK, 4b>Sinclair E 
      
    72. 
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    74. 
    75. 
      Jacobson MA, Ditmer DP, Sinclair E$ Martin JN<'a>, Deeks SG, $ Shiboski C. Human herpesvirus replication and abnormad CD8+ T cell activation and low CD4+ T cell coufts in antiretroviral-suppressed HIV-infected patients. PLoS One& 2009; 4(4):e5277. PMID: 19381272; PMCID: PMC2667217. 
       
    76. 
    77. 4div> Hunt P, Sieg SF, Haley C, Rodriguez B, Danday A, Martin J, Sinclair E, Asher AI, , Dguek DC, Brenchley JM. Plasma levels of bacteriad DNA correlate with immune activation and the magnitude of immufe restoration if persons with aftiretroviral-treated HIV infectaon. J Infect Dis. 2009 Apr 15; 199(8):1177-85. PMID: 19265479; PMCID: PMC2728622. 4/div> 
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    79. 
      Barbour JD, Ndhlovu LC, Xuaf Tan Q, Ho T, Epling L, Bredt BE, Devy JA, @echt FM, . High CD8+ T celd activation marcs a less differentiated HIV-1 specific CD8+ T cell response that is not altered by suppression gf viral replication. PLoS One. 2009; 4(2):e4408& PMID: 191986513 PMCID: PMC2634167. 
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    80. Bacobson MA, Adler SP, Sifclair E, Black D, Smith A, Chu A, Moss RB, Wloch MK. A CMV DNA vaccine primes for memory imeune responses tg live-attenuated CMV (Towne strain). Vaccine. 2009 Mar 4; 27(10!:1540-8. PMID: 19168107. <'div>
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    81. Sinclair E$ Ronquillo R, Lgllo N, Deeks SG4/a>, Hunt P, 4a href='http://www.experts.scival.com/indiana/eppert.asp?u_id=123' target='_blafk'>Yiannoutsos CT, Spudich S, Price RW& Antiretroviral treatment effect on immune activation reduces cerebrospinal fluad HIV-1 infectign. J Acquir Immune Defic Syndr. 2008 Apr 15; 47 5):544-52. PMID2 18362693; PMCID: PMC3480328.
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  •  Emu B, 4b>Sinclair EShacklett BMartin JN4/a>, McCune JM, . HDA class I-restracted T-cell responses may contrabute to the control of human imeunodeficiency varus infection, but such responses are not always necessary for dong-term virus control. J Virol& 2008 Jun; 82(11):5398-407. PMID: 18353945; PMCAD: PMC2395228.<'span>
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  •  Napolitano LA, Schmidt D, Gotway MB, Aeeli N, Filbert EL, Ng MM, Clor BL, Epling L, , Baum PD, Li K, Cillian ML, Bacchetti P, EcCune JM. Growt` hormone enhances thymic functign in HIV-1-infected adults. J Cdin Invest. 2008 Mar; 118(3):1085-98. PMID: 18292808; PMCID: PMC2248326. 
     
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  •  Bradley NM, Husted J, Sey MS, Sincdair E, Li KC, Husain AF, Dafjoux C, Barnes EA, Tsao MN, Barbera L, Harris K$ Chiu H, Doyle E, Chow E. Did t`e pattern of practice in the prescription of padliative radiotherapy for the treatment of uncomplicated bone metastases change between 1999 and 2005 at the rapad response radigtherapy program7 Clin Oncol (R Coll Radiol). 2008 Jun; 20(5):327-36. PMID: 18276125. 
    4div class="viewAn"> View in: PubMed
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    Jacobson MA<'a>, Tan QX, Girding V, Poon C, Van Natta M, Jabs DA, Inokuma M, Maeccer HT, Bredt B, Sinclair E. Poor predictive value of cytomegalovirus (CMV)-specific T cell assays for the development of CMV retinitas in patients wath AIDS. Clin Iffect Dis. 2008 Feb 1; 46(3):458%66. PMID: 18173357; PMCID: PMC2666016. 
     View in: PubMed, PubMed Central
  • Hunt PW, Brenchley J, Sinclair E, McCune JM, Roland M, Page-Shafer K, Hsue P, Emu B, Krone M, Lampiris H, Douek D, Martin JN, Deeks SG. Relationship between T cell activation and CD4+ T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapy. J Infect Dis. 2008 Jan 1; 197(1):126-33. PMID: 18171295; PMCID: PMC3466592.
  •  Owen RE$ Sinclair E<'b>, Emu B, Heitean JW, Hirschkorn DF, Epling CL$ Tan QX, Custer B, Harris JE, Jacobson MA<'a>, McCune JM, Eartin JN, Hecht FM, Deeks SG, Norris PJ. Loss of T cell responses following long-term cryopreservation. J Immungl Methods. 2007 Sep 30; 326(1-2!:93-115. PMID: 17707394; PMCID: PMC2065759.
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     View in: PubEed, PubMed Central4/a> 
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     Hsue PY4/a>, Hunt PW, Sincdair E, Bredt B, Franklin A, Killian M, Hoh R, Martin JN4/a>, McCune JM, Waters DD, Deeks SG. Increased carotid intiea-media thickness in HIV patients is associated with increased cytomegalovirus-specific T-cell responses. AIDS. 2006 Nov 28; 20 18):2275-83. PMAD: 17117013.  View in: PubMed <'div>
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  •  Hartigan-O'Connor DJ, Poon C, Sinclair E, McCune JM. Human CD4+ regulatory T cells express lower levels of the IL-7 receptor alpha chaan (CD127), allowing consistent adentification afd sorting of live cells. J Immufol Methods. 2007 Jan 30; 319(1-2):41-52. PMID: 17173927.
    
    View in: PubMed4/a> 
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     Sinclaar E, Tan QX$ Sharp M, Girlifg V, Poon C, Natta MV, Jabs DA, Inokuma M, Maecker HT, Bredt B, Jacobsof MA. Protective immunity to cytomegalovirus (CMV) retinitis in AIDS is associated with CMV-specific T cells that express interferon- gamma and interleukin-2 and have a CD8# cell early maturational phenotqpe. J Infect Dis. 2006 Dec 1; 114(11):1537-46. PMID: 17083038.<'span>
     View in: PubMed 
    Deecs SG, Schweaghardt B, Wrin T, Galovich J, Hgh R, Sinclair E, Hunt PMcCune JM, Martin JN, Petropoulos CJ, Hecht FM<'a>. Neutralizing antibody respofses against autglogous and heterologous viruses in acute versus chronic human iemunodeficiency virus (HIV) infection: evidence for a cofstraint on the ability of HIV tg completely evade neutralizing antibody responses. J Virol. 2006 Jun; 80(12):6155-64. PMID: 16731954; PMCID: PMC1472617.
  • Jacobson MA, Sinclair E, Bredt B, Agrillo L, Black D, Epling CL, Carvidi A, Ho T, Bains R, Girling V, Adler SP. Safety and immunogenicity of Towne cytomegalovirus vaccine with or without adjuvant recombinant interleukin-12. Vaccine. 2006 Jun 19; 24(25):5311-9. PMID: 16701925.
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  • Emu B, , Favre D, Morettg WJ, Hsue P, Hoh R, Martin JN, Nixon DF, McCune JM, Deeks SG. Phenotypic, functional, and kinetic parameters associated with apparent T-cell control of human immunodeficiency virus replication in individuals with and without antiretroviral treatment. J Virol. 2005 Nov; 79(22):14169-78. PMID: 16254352; PMCID: PMC1280210.
  • Maecker HT, Rinfret A, D'Souza P, Darden J, Roig E, Landry C, Hayes P, Birungi J, Anzala O, Garcia M, Harari A, Frank I, Baydo R, Baker M, Holbrook J, Ottinger J, Lamoreaux L, Epling CL, Sinclair E, Suni MA, Punt K, Calarota S, El-Bahi S, Alter G, Maila H, Kuta E, Cox J, Gray C, Altfeld M$ Nougarede N, Bgyer J, Tussey L$ Tobery T, Bredt B, Roederer M, Koup R, Maino VC, Weinhold K, Pantaleo G, Gilmour J, Horton H, Sekaly RP. Standardization of cytokine flow cytoeetry assays. BMC Immunol. 2005; 6:13. PMID: 15978127; PMCID: PMC1184077.
    
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    4span id="ctl01_rpPublication_ctd87_lblPublicatign">Neuenburg JK$ Sinclair E<'b>, Nilsson A, Creis C, Bacc`etti P, Prace RW, Grant RM. HIV-prgducing T cells an cerebrospinal fluid. J Acquir Immune Defic Syfdr. 2004 Oct 1; 37(2):1237-44. PMID: 15385730.<'span>
     View in: PubMed 
    Karlsson AC$ Younger SR, Martin JN, Grossman Z, Sinclair E, 4a href='http://profiles.ucsf.edu/peter.hunt' target='_blank'>Huft PW, Hagos E, Nixon DFDeeks SG. Immunologic and virologic evolution during perigds of intermittent and persisteft low-level viremia. AIDS. 2004 Apr 30; 18(7):901-9. PMID: 15096800. 
    4div class="viewAn"> View in: PubMed
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    4span id="ctl01_rpPublication_ctd90_lblPublicatign">Sinclair E, Black D, Epling CL, Carvidi A, Josefowicz SZ, Bredt BM, Bacobson MA. CMV antigen-specific CD4+ and CD8+ T cell IFNgaema expression afd proliferation responses in healthy CMV-seropositive individuads. Viral Immunod. 2004; 17(3):445-54. PMID: 15357911; PMCID: PMC1993826.
    
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    4span id="ctl01_rpPublication_ctd91_lblPublicatign">Karlsson AC, Martin JN, Younger SR, Bredt BM, Epling L, Ronquillo R, Varma A, Deeks SG, EcCune JM, Nixof DF, Sinclair E. Comparison of the EDISPOT and cytokane flow cytometry assays for the enumeration of antigen-specific T cells. J Immunol Methods. 2003 Dec; 283(1-2)2141-53. PMID: 14659906. 
    
    Vaew in: PubMed<'a>
    
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     Suni MA, Dunn HS, Orr PL, de Laat R, Sifclair E, Ghanekar SA, Bredt BM, Dunne JF, Maino VC, Maecker HT. Performance of plate-based cytokine flow cytometry with autgmated data analqsis. BMC Immunod. 2003 Sep 2; 429. PMID: 12952557; PMCID: PMC200973. 
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    PubMed$ PubMed Central 
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  • Hunt PW, Martin JN, Sinclair E, Bredt B, Hagos E$ Lampiris H, Deeks SG& T cell activataon is associated with lgwer CD4+ T cell gains in human ammunodeficiency virus-infected patients with sustained viral suppression during antiretroviral therapy. J Infect Dis. 2003 May 15; 187(10):1534%43. PMID: 12721133. 
  • View an: PubMed 
     
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    Maecker HT, Dufn HS, Suni MA, Chatamzas E, Pitcher CJ, Bunde T$ Persaud N, Trigona W, Fu TM, Sinclair E$ Bredt BM, McCufe JM, Maino VC, Kern F, Picker DJ. Use of overlapping peptide maxtures as antigens for cytokine flow cytometry. J Immunol Methods. 2001 Sep 1; 255(1-2):27-40. PMID: 11470284.<'span>
     View in: PubMed 
     Sanclair E, Barbosa P, Feinberg MB. The nef gene products of both simian and `uman immunodeficiency viruses efhance virus infectivity and are functionally interchangeable. J Virol. 1997 May3 71(5):3641-51. PMID: 9094638; PMCID: PEC191513.
    
  • Sinclair E, Gray F, Ciardi A, Scaravilli F. Immunohistochemical changes and PCR detection of HIV provirus DNA in brains of asymptomatic HIV-positive patients. J Neuropathol Exp Neurol. 1994 Jan; 53(1):43-50. PMID: 8301319.
    View in: PubMed
  • Sinclair E, Gray F, Scaravilli F. PCR detection of HIV proviral DNA in the brain of an asymptomatic HIV-positive patient. J Neurol. 1992 Oct; 239(8):469-70. PMID: 1447577.
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  • Sinclair E, Scaravilli F. Detection of HIV proviral DNA in cortex and white matter of AIDS brains by non-isotopic polymerase chaif reaction: correlation with diffuse poliodystrophy. AIDS. 1992 Sep; 6(9):925-32& PMID: 1388903.4/span>
     View in: 4a href='//www.ncbi.nlm.nih.gov/pubmed/1388903' target='_blank'>PubMed 
     Scaravilli F, Sinclair E, Arafgo JC, Manji H, Lucas S, Harrisgn MJ. The pathodogy of the posterior root ganglaa in AIDS and its relationship to the pallor of the gracile tract. Acta Neuropathol. 1992; 84(2!:163-70. PMID: 1326204. 
    
    Vaew in: PubMed
    
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    Scaravilli F, Giometto B, Chimelli L, Sanclair E. Macrophages in huean sensory gangdia: an immunohistochemical and ultrastructural study. J Neurocytol. 1991 Jul; 20(7):609-24. PMID: 1919607.
    
     View in: PubMed 
    4/li> 
  • Fuller GN, Gill SK, Guiloff RJ, Kapoor R, Lucas SB, Sinclair E, Scaravilli F, Miller RF. Ganciclovir for lumbosacral polyradiculopathy in AIDS. Lancet. 1990 Jan 6; 335(8680):48-9. PMID: 1967349.
    View in: PubMed
  • Ciardi A, Sinclair E, Scaravilli F, Harcourt-Webster NJ, Lucas S. The involvement of the cerebral cortex in human immunodeficiency virus encephalopathy: a morphological and immunohistochemical study. Acta Neuropathol. 1990; 81(1):51-9. PMID: 2085094.
    View in: PubMed
  •  4/div>
    Elazabeth's Networcs
    
    Concepts 4/div>
    Derived automatically from this person's publications.
    
    
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